MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Malignant Hypertension

(UMLS:C0020540)

Definition:: A condition of markedly elevated BLOOD PRESSURE with DIASTOLIC PRESSURE usually greater than 120 mm Hg. Malignant hypertension is characterized by widespread vascular damage, PAPILLEDEMA, retinopathy, HYPERTENSIVE ENCEPHALOPATHY, and renal dysfunction.
UMLS ID:: C0020540
MeSH ID:: D006974

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.489.330

Synonym(s)

Malignant Hypertension

Accelerated hypertension

HYPERTENSION ACCELERATED

HYPERTENSION MALIGNANT

HYPERTENSION, ACCELERATED

Hypertension;malignant

Malignant hypertension

accelerated hypertension

hypertension malignant

10.

malignant hypertension

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 16	US FAERS
2	Rosiglitazone	FAERS: 12	OFFSIDES US FAERS
3	Quetiapine Fumarate	FAERS: 10	US FAERS
4	rofecoxib	FAERS: 10	OFFSIDES US FAERS
5	Sunitinib	FAERS: 7	US FAERS
6	Cyclosporine	FAERS: 5	US FAERS
7	Nifedipine	FAERS: 5	OFFSIDES SIDER US FAERS
8	Ortho Evra	FAERS: 5	US FAERS
9	Nebivolol	FAERS: 4	US FAERS
10	aliskiren	FAERS: 4	US FAERS
11	Duloxetine Hydrochloride	FAERS: 3	US FAERS
12	Leflunomide	FAERS: 3	SIDER US FAERS
13	Linezolid	FAERS: 3	US FAERS
14	Norgestrel	FAERS: 3	US FAERS
15	Venlafaxine Hydrochloride	FAERS: 3	US FAERS
16	teriflunomide	FAERS: 3	US FAERS
17	Acetaminophen	FAERS: 2	US FAERS
18	Acyclovir	FAERS: 2	US FAERS
19	Atazanavir Sulfate	FAERS: 2	OFFSIDES US FAERS
20	Levomilnacipran	FAERS: 2	US FAERS
21	Quetiapine Fumarate	FAERS: 2	US FAERS
22	Rivaroxaban	FAERS: 2	US FAERS
23	Sumatriptan	FAERS: 2	US FAERS
24	Sunitinib	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
25	Valsartan	FAERS: 2	OFFSIDES US FAERS
26	Zoledronic Acid	FAERS: 2	US FAERS
27	carfilzomib	FAERS: 2	US FAERS
28	gemcitabine	FAERS: 2	US FAERS
29	gemcitabine	FAERS: 2	US FAERS
30	mirabegron	FAERS: 2	US FAERS
31	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
32	Alprazolam	FAERS: 1	US FAERS
33	Amlodipine	FAERS: 1	US FAERS
34	Atacand hct	FAERS: 1	US FAERS
35	Atenolol	FAERS: 1	US FAERS
36	Breo Ellipta	FAERS: 1	US FAERS
37	Citalopram	FAERS: 1	US FAERS
38	Clopidogrel	FAERS: 1	US FAERS
39	Dimethyl Fumarate	FAERS: 1	US FAERS
40	Estradiol	FAERS: 1	US FAERS
41	Exenatide	FAERS: 1	US FAERS
42	Fingolimod Hydrochloride	FAERS: 1	US FAERS
43	Glatiramer Acetate	FAERS: 1	US FAERS
44	Guanfacine	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
45	Ibuprofen	FAERS: 1	US FAERS
46	Isoflurane	FAERS: 1	US FAERS
47	Mycophenolic Acid	FAERS: 1	US FAERS
48	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	FAERS: 1	SIDER US FAERS
49	Nitroglycerin	FAERS: 1	OFFSIDES US FAERS
50	Octreotide	FAERS: 1	US FAERS
51	Olanzapine	FAERS: 1	US FAERS
52	Oxcarbazepine	FAERS: 1	US FAERS
53	Oxymorphone	FAERS: 1	US FAERS
54	Paroxetine	FAERS: 1	US FAERS
55	Prasugrel Hydrochloride	FAERS: 1	US FAERS
56	Propofol	FAERS: 1	US FAERS
57	Risperidone	FAERS: 1	US FAERS
58	Rivastigmine	FAERS: 1	US FAERS
59	Sevelamer	FAERS: 1	OFFSIDES US FAERS
60	Sitagliptin Phosphate	FAERS: 1	OFFSIDES US FAERS
61	Solifenacin Succinate	FAERS: 1	US FAERS
62	Tacrolimus	FAERS: 1	OFFSIDES US FAERS
63	Telmisartan	FAERS: 1	US FAERS
64	Teriparatide	FAERS: 1	US FAERS
65	Varenicline	FAERS: 1	US FAERS
66	ambrisentan	FAERS: 1	US FAERS
67	apremilast	FAERS: 1	US FAERS
68	betamethasone acetate phosphate	FAERS: 1	US FAERS
69	brinzolamide	FAERS: 1	US FAERS
70	etonogestrel	FAERS: 1	US FAERS
71	exemestane	FAERS: 1	OFFSIDES US FAERS
72	niraparib	FAERS: 1	US FAERS
73	pazopanib	FAERS: 1	US FAERS
74	pazopanib	FAERS: 1	US FAERS
75	prednisolone phosphate	FAERS: 1	US FAERS
76	tofacitinib	FAERS: 1	US FAERS
77	valdecoxib	FAERS: 1	US FAERS
78	ziprasidone	FAERS: 1	US FAERS
79	1 alpha-hydroxyergocalciferol		OFFSIDES
80	Allopurinol		OFFSIDES
81	Bendroflumethiazide		OFFSIDES
82	Bortezomib		OFFSIDES
83	Captopril		OFFSIDES
84	Carisoprodol		OFFSIDES
85	Chlorthalidone		OFFSIDES
86	Ciclopirox		OFFSIDES
87	Clobazam		OFFSIDES
88	Colestipol		OFFSIDES
89	Desflurane		SIDER
90	Diltiazem		OFFSIDES
91	Dioctyl Sulfosuccinic Acid		OFFSIDES
92	Diphenhydramine		OFFSIDES
93	Enalaprilat		OFFSIDES
94	Enalapril		OFFSIDES
95	Ephedrine		OFFSIDES
96	Erlotinib Hydrochloride		OFFSIDES
97	Estrogens, Conjugated (USP)		OFFSIDES
98	Ezetimibe		OFFSIDES
99	Felodipine		OFFSIDES
100	Fenofibrate		OFFSIDES
101	Fludrocortisone		OFFSIDES
102	Fluorouracil		OFFSIDES
103	Glipizide		OFFSIDES
104	Glyburide		OFFSIDES
105	Hydralazine		OFFSIDES
106	Ketoconazole		OFFSIDES
107	Labetalol		OFFSIDES
108	Lansoprazole		OFFSIDES
109	Leucovorin		OFFSIDES
110	Levodopa		OFFSIDES
111	Meloxicam		OFFSIDES
112	Metformin		OFFSIDES
113	Methylphenidate		OFFSIDES
114	Metolazone		OFFSIDES
115	Minoxidil		OFFSIDES
116	Mitomycin		OFFSIDES
117	Mupirocin		OFFSIDES
118	Nadolol		OFFSIDES
119	Nizatidine		OFFSIDES
120	Nystatin		OFFSIDES
121	Pemetrexed		OFFSIDES
122	Perindopril		OFFSIDES
123	Probenecid		OFFSIDES
124	Rocuronium		OFFSIDES
125	Saridon		OFFSIDES
126	Sirolimus		OFFSIDES
127	Sodium Bicarbonate		OFFSIDES
128	Temazepam		OFFSIDES
129	Tenofovir		OFFSIDES
130	Terazosin		OFFSIDES
131	Testosterone		OFFSIDES
132	Tramadol		OFFSIDES
133	Verapamil		OFFSIDES
134	Xipamide		OFFSIDES
135	abacavir		OFFSIDES
136	alfacalcidol		OFFSIDES
137	cabozantinib		SIDER
138	calcium acetate		OFFSIDES
139	darifenacin		OFFSIDES
140	gadodiamide		OFFSIDES
141	gadoversetamide		OFFSIDES
142	paricalcitol		OFFSIDES
143	sibutramine		OFFSIDES SIDER
144	urapidil		OFFSIDES
145	vinflunine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Essential Hypertension	46.7%
2	White Coat Hypertension	46.7%
3	Hypertensive Retinopathy	31.8%
4	Aneurysm	31%
5	Angiomatosis	31%
6	Aortic Diseases	31%
7	Arterial Occlusive Diseases	31%
8	Hyperemia	31%
9	Hypotension	31%
10	Superior Vena Cava Syndrome	31%
11	Telangiectasis	31%
12	Vasculitis	31%
13	Venous Insufficiency	31%
14	Peripheral Vascular Diseases	31%
15	Embolism and Thrombosis	31%
16	Angiodysplasia	31%
17	Capillary Leak Syndrome	31%
18	Prehypertension	31%
19	Myocardial Ischemia	27.9%
20	Aortic Aneurysm	26.7%
21	Aortitis	26.7%
22	Leriche Syndrome	26.7%
23	Periphlebitis	26.7%
24	Phlebitis	26.7%
25	Thromboangiitis Obliterans	26.7%
26	Renal hypertension	23.1%
27	Postphlebitic Syndrome	23.1%
28	Vascular System Injuries	22%
29	Retinal Vein Occlusion	21.7%
30	Compartment syndromes	20.9%
31	Hepatic Veno-Occlusive Disease	20.9%
32	Peliosis Hepatis	20.9%
33	Varicocele	20.9%
34	Thrombophlebitis	20.6%
35	Cerebrovascular Disorders	20.5%
36	Diabetic Angiopathies	20.5%
37	Reperfusion Injury	20.5%
38	Splenic Infarction	20.5%
39	Cerebrovascular Insufficiency	20.5%
40	Vascular Neoplasms	20.5%
41	Spinal Cord Vascular Diseases	20.5%
42	Vasoplegia	20.5%
43	Blue Toe Syndrome	20.4%
44	Hemorrhoids	20.2%
45	Thoracic Outlet Syndrome	20.2%
46	Aneurysm, Dissecting	20%
47	Arteriosclerosis	20%
48	Arteritis	20%
49	Embolism	20%
50	Erythromelalgia	20%
51	Fibromuscular Dysplasia	20%
52	Raynaud Disease	20%
53	Thromboembolism	20%
54	Thrombosis	20%
55	Aneurysm, Ruptured	20%
56	Iliac Aneurysm	20%
57	Malignant Atrophic Papulosis	20%
58	Pulmonary artery stenosis	20%
59	Systemic Vasculitis	20%
60	Embolus	20%
61	Shwartzman Phenomenon	19.8%
62	Coronary Aneurysm	19.7%
63	Aortic Aneurysm, Abdominal	19.6%
64	Aortic Aneurysm, Thoracic	19.6%
65	Heart Diseases	18.5%
66	Aortic Rupture	17.9%
67	Coronary heart disease	17.8%
68	Myocardial Infarction	17.8%
69	Acute Coronary Syndrome	17.8%
70	Myocardial Reperfusion Injury	17.7%
71	Intracranial Embolism and Thrombosis	17.2%
72	Carotid Stenosis	17.1%
73	Intracranial Aneurysm	17.1%
74	Coronary Thrombosis	17.1%
75	Coronary Artery Disease	17.1%
76	Hypertension, Renovascular	17%
77	Carotid Artery Thrombosis	16.5%
78	Hand-Arm Vibration Syndrome	16.1%
79	Optic Neuropathy, Ischemic	15.5%
80	Anterior Ischemic Optic Neuropathy	15.5%
81	Mesenteric vascular insufficiency	15.5%
82	Moyamoya Disease	15.3%
83	Angioedema	15%
84	Colitis, Ischemic	14.9%
85	Arteriosclerosis Obliterans	14.8%
86	Atherosclerosis	14.8%
87	Air Embolism	14.8%
88	Endarteritis	14.8%
89	Polyarteritis Nodosa	14.8%
90	Takayasu Arteritis	14.8%
91	Venous Thrombosis	14.8%
92	Deep Vein Thrombosis	14.8%
93	Venous Thromboembolism	14.8%
94	Intracranial Arteriosclerosis	14.6%
95	Cerebral Atherosclerosis	14.6%
96	Cerebral Arteriosclerosis	14.6%
97	Arteriovenous fistula	14%
98	Retinal Artery Occlusion	13.6%
99	Retinal Vasculitis	13.6%
100	Kounis Syndrome	13.6%
101	Vasculitis, Central Nervous System	13.4%
102	Anterior Compartment Syndrome	13.3%
103	Vasculitis, Leukocytoclastic, Cutaneous	13.3%
104	Gastric Antral Vascular Ectasia	13.3%
105	Abdominal Compartment Syndrome	13.3%
106	Cerebral Thrombosis	13.3%
107	Intracranial Embolism	13.3%
108	Intracranial Thrombosis	13.3%
109	May-Thurner Syndrome	13.2%
110	Carotid Artery Diseases	13.2%
111	Brain Ischemia	13.2%
112	Hypotension, Orthostatic	13.2%
113	Cerebrovascular accident	13.2%
114	Varicose Ulcer	13.2%
115	Vasospasm, Intracranial	13.2%
116	Spinal Cord Ischemia	13.2%
117	Intracranial Arterial Diseases	13.2%
118	Primary Graft Dysfunction	13.2%
119	Post-Exercise Hypotension	13.2%
120	Angina Pectoris	13.2%
121	Coronary Occlusion	13%
122	Microvascular Angina	13%
123	Coronary Stenosis	13%
124	ST segment elevation myocardial infarction	13%
125	Embolism, Amniotic Fluid	12.6%
126	Pregnancy Complications, Cardiovascular	12.2%
127	Cardiovascular Abnormalities	12.2%
128	Brain Infarction	11.6%
129	Sinus Thrombosis, Intracranial	11.4%
130	Giant Cell Arteritis	11%
131	Temporal Arteritis	11%
132	Coronary Restenosis	10.8%
133	Scimitar Syndrome	10.7%
134	Cavernous Sinus Thrombosis	10.5%
135	Sagittal Sinus Thrombosis	10.5%
136	Cardiac Tamponade	10.3%
137	Endocarditis	10.3%
138	Cardiac Arrest	10.3%
139	Heart failure	10.3%
140	Pericardial effusion	10.3%
141	Pericarditis	10.3%
142	Pneumopericardium	10.3%
143	Cor pulmonale	10.3%
144	Ventricular Outflow Obstruction	10.3%
145	Ventricular Dysfunction	10.3%
146	Cardiomyopathies	10.3%
147	Pleuropericarditis	10.3%
148	Lemierre Syndrome	10.2%
149	Mesenteric Vascular Occlusion	10.2%
150	Mucocutaneous Lymph Node Syndrome	10.2%
151	Intermittent Claudication	10.1%
152	Pulmonary Embolism	10.1%
153	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10.1%
154	Diabetic Retinopathy	10.1%
155	Sturge-Weber Syndrome	10.1%
156	Livedo Reticularis	10%
157	Renal Artery Obstruction	9.9%
158	Renal Artery Stenosis	9.9%
159	No-Reflow Phenomenon	9.9%
160	Hemangioma, Cavernous	9.8%
161	Shock, Cardiogenic	9.8%
162	Basal Ganglia Cerebrovascular Disease	9.8%
163	Vertebral Artery Dissection	9.8%
164	Vascular Headaches	9.8%
165	Scurvy	9.8%
166	CREST Syndrome	9.7%
167	Cerebral Arterial Diseases	9.7%
168	Vertebrobasilar Insufficiency	9.7%
169	Anterior Spinal Artery Syndrome	9.7%
170	Basilar Artery Stenosis	9.7%
171	Vertebral Artery Stenosis	9.7%
172	Intracranial Hemorrhage, Hypertensive	9.7%
173	Transient Cerebral Ischemia	9.7%
174	Angina, Unstable	9.7%
175	Subarachnoid Hemorrhage, Traumatic	9.6%
176	Carotid Artery, Internal, Dissection	9.6%
177	Cerebral Infarction	9.6%
178	Brain Stem Infarctions	9.6%
179	Infarction, Middle Cerebral Artery	9.5%
180	Infarction, Anterior Cerebral Artery	9.5%
181	Infarction, Posterior Cerebral Artery	9.5%
182	Aortic Valve Stenosis	8.9%
183	Cardiomyopathy, Dilated	8.9%
184	Pulmonary Valve Stenosis	8.9%
185	Lateral Medullary Syndrome	8.6%
186	Hepatic Vein Thrombosis	8.4%
187	Budd-Chiari Syndrome	8.4%
188	Carotid Artery Injuries	8.4%
189	Pulmonary Infarction	8.2%
190	Subclavian Steal Syndrome	8%
191	Angina Pectoris, Variant	8%
192	Ischemic contracture	8%
193	Angioedemas, Hereditary	7.9%
194	Tricuspid Atresia	7.9%
195	Arrhythmogenic Right Ventricular Dysplasia	7.9%
196	Cryoglobulinemia	7.9%
197	Leukomalacia, Periventricular	7.9%
198	Diabetic Foot	7.8%
199	Basal Ganglia Hemorrhage	7.5%
200	Subarachnoid Hemorrhage	7.3%
201	Hypoxia-Ischemia, Brain	7.3%
202	Cerebral Hemorrhage	7.3%
203	Hereditary Angioedema Type III	7.2%
204	Hereditary Angioedema Types I and II	7.2%
205	Hypertrophic Cardiomyopathy	7.1%
206	Hypertrophic obstructive cardiomyopathy	7.1%
207	Cardiac Output, High	7%
208	Myocardial Stunning	7%
209	Low Cardiac Output Syndrome	7%
210	Bacterial Endocarditis	6.8%
211	Cardiomegaly	6.8%
212	Postpericardiotomy Syndrome	6.8%
213	Cardiac Hypertrophy	6.8%
214	Rheumatic Heart Disease	6.7%
215	Aortic Valve Insufficiency	6.7%
216	Restrictive cardiomyopathy	6.7%
217	Endocardial Fibroelastosis	6.7%
218	Heart Block	6.7%
219	Heart Rupture, Post-Infarction	6.7%
220	Mitral Valve Insufficiency	6.7%
221	Mitral Valve Stenosis	6.7%
222	Myocarditis	6.7%
223	Pericarditis, Constrictive	6.7%
224	Pulmonary Valve Insufficiency	6.7%
225	Tachycardia	6.7%
226	Tricuspid Valve Insufficiency	6.7%
227	Tricuspid Valve Stenosis	6.7%
228	Tachyarrhythmia	6.7%
229	Ventricular Dysfunction, Left	6.7%
230	Right Ventricular Dysfunction	6.7%
231	Endomyocardial Fibrosis	6.7%
232	Carditis	6.7%
233	Heart Failure, Systolic	6.7%
234	Heart Failure, Diastolic	6.7%
235	Aortic coarctation	6.6%
236	Cor Triatriatum	6.6%
237	Coronary Vessel Anomalies	6.6%
238	Patent ductus arteriosus	6.6%
239	Ebstein Anomaly	6.6%
240	Heart Septal Defects	6.6%
241	Tetralogy of Fallot	6.6%
242	Transposition of Great Vessels	6.6%
243	Hypoplastic Left Heart Syndrome	6.6%
244	Shy-Drager Syndrome	6.5%
245	Supravalvular aortic stenosis	6.5%
246	Lown-Ganong-Levine Syndrome	6.5%
247	Purpura, Hyperglobulinemic	6.5%
248	Putaminal Hemorrhage	6.5%
249	Granulomatosis with polyangiitis	6.2%
250	Dementia, Vascular	6.1%
251	Cerebral Amyloid Angiopathy	6%
252	Pituitary Apoplexy	5.9%
253	Behcet Syndrome	5.7%
254	Waldenstrom Macroglobulinemia	5.7%
255	Multiple Myeloma	5.7%
256	Dextrocardia	5.3%
257	Long QT Syndrome	5.3%
258	Ataxia Telangiectasia	5.1%
259	Pseudoxanthoma Elasticum	5%
260	Aortic Valve Prolapse	4.9%
261	Tricuspid Valve Prolapse	4.9%
262	Rheumatoid Vasculitis	4.9%
263	Takotsubo Cardiomyopathy	4.9%
264	Adams-Stokes Syndrome	4.9%
265	Atrioventricular Block	4.9%
266	Bundle-Branch Block	4.9%
267	Atrial Premature Complexes	4.9%
268	Sinoatrial Block	4.9%
269	Tachycardia, Paroxysmal	4.9%
270	Supraventricular tachycardia	4.9%
271	Tachycardia, Ventricular	4.9%
272	Wolff-Parkinson-White Syndrome	4.9%
273	Tachycardia, Reciprocating	4.9%
274	Lupus Vasculitis, Central Nervous System	4.9%
275	Sick Sinus Syndrome	4.9%
276	Aortopulmonary Septal Defect	4.9%
277	Double Outlet Right Ventricle	4.9%
278	Endocardial Cushion Defects	4.9%
279	Myocardial bridging	4.9%
280	Aorticopulmonary Septal Defect	4.9%
281	Sinus Arrhythmia	4.4%
282	Atrial Fibrillation	4.4%
283	Atrial Flutter	4.4%
284	Edema, Cardiac	4.4%
285	Ventricular Fibrillation	4.4%
286	Ventricular Flutter	4.4%
287	Parasystole	4.4%
288	Paroxysmal atrial fibrillation	4.4%
289	Bradycardia	4.4%
290	Diabetic Cardiomyopathies	4.4%
291	Cardiomyopathy, Alcoholic	4.4%
292	Ectopia Cordis	4.4%
293	Sudden Cardiac Death	4.4%
294	Left Ventricular Hypertrophy	4.4%
295	Right Ventricular Hypertrophy	4.4%
296	Single umbilical artery	4.4%
297	Chagas Cardiomyopathy	4.4%
298	Tachycardia, Atrioventricular Nodal Reentry	4%
299	Tachycardia, Ectopic Atrial	4%
300	Tachycardia, Ectopic Junctional	4%
301	Sinus Tachycardia	4%
302	Torsades de Pointes	4%
303	Accelerated Idioventricular Rhythm	4%
304	Truncus Arteriosus, Persistent	4%
305	Carcinoid Heart Disease	3.9%
306	Romano-Ward Syndrome	3.9%
307	Subacute Bacterial Endocarditis	3.8%
308	Noonan Syndrome	3.8%
309	Hematoma, Subdural	3.5%
310	Hematoma, Epidural, Cranial	3.5%
311	Marfan Syndrome	3.4%
312	Dyspnea, Paroxysmal	3.3%
313	Sinus Arrest, Cardiac	3.3%
314	Hematoma, Subdural, Intracranial	3.1%
315	Hematoma, Subdural, Chronic	3.1%
316	Hematoma, Subdural, Acute	3.1%
317	Brain Hemorrhage, Traumatic	3%
318	MELAS Syndrome	2.9%
319	Dural Arteriovenous Fistula	2.7%
320	Fabry Disease	2.2%
321	Turner Syndrome	1.8%
322	Williams Syndrome	1.6%
323	Kartagener Syndrome	1.5%
324	Kearns-Sayre syndrome	1.2%

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