MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Frontotemporal dementia

(UMLS:C0338451)

Definition:: The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.
UMLS ID:: C0338451
MeSH ID:: D057180

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.380.266.299|C10.574.950.300.299

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.845.800.300.299

Classification 3:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.615.400.380.299

Synonym(s)

Frontotemporal dementia

FRONTOTEMPORAL DEMENTIA

Frontotemporal Dementia

Pick's disease

Picks disease

dementia frontotemporal

frontotemporal dementia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Donepezil	FAERS: 5		US FAERS
2	Rivastigmine	FAERS: 5		US FAERS
3	Clozapine	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
4	Methotrexate	FAERS: 3		US FAERS
5	Mycophenolic Acid	FAERS: 3		US FAERS
6	Paroxetine	FAERS: 3		US FAERS
7	Quetiapine Fumarate	FAERS: 3		US FAERS
8	Risperidone	FAERS: 3	18217890	CTD US FAERS
9	Clotrimazole and betamethasone dipropionate	FAERS: 2		US FAERS
10	Fluoxetine	FAERS: 2		US FAERS
11	Acarbose	FAERS: 1		US FAERS
12	Atorvastatin	FAERS: 1		US FAERS
13	Baclofen	FAERS: 1		US FAERS
14	Carbidopa, levodopa, and entacapone	FAERS: 1		US FAERS
15	Carmustine	FAERS: 1		US FAERS
16	Dimethyl Fumarate	FAERS: 1		US FAERS
17	Ezetimibe, Simvastatin Drug Combination	FAERS: 1		US FAERS
18	Fluoxetine	FAERS: 1		US FAERS
19	Galantamine	FAERS: 1		US FAERS
20	Galantamine	FAERS: 1		US FAERS
21	Mycophenolic Acid	FAERS: 1		US FAERS
22	Olanzapine	FAERS: 1	18217890	CTD US FAERS
23	Pregabalin	FAERS: 1		US FAERS
24	Rivaroxaban	FAERS: 1		US FAERS
25	Rosiglitazone	FAERS: 1		US FAERS
26	Rosuvastatin Calcium	FAERS: 1		US FAERS
27	Sertraline	FAERS: 1		US FAERS
28	Valproic Acid	FAERS: 1		US FAERS
29	Valproic Acid	FAERS: 1		US FAERS
30	Valsartan	FAERS: 1		US FAERS
31	Varenicline	FAERS: 1		US FAERS
32	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
33	Zoledronic Acid	FAERS: 1		US FAERS
34	Zolpidem	FAERS: 1		US FAERS
35	apixaban	FAERS: 1		US FAERS
36	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
37	eribulin	FAERS: 1		US FAERS
38	estradiol, norethindrone drug combination	FAERS: 1		US FAERS
39	pimavanserin	FAERS: 1		US FAERS
40	suvorexant	FAERS: 1		US FAERS
41	Quetiapine Fumarate		18217890	CTD
42	Vorinostat		21454553	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lewy Body Disease	28.9%
2	Amyotrophic Lateral Sclerosis	26.6%
3	Presenile dementia	26.4%
4	Senile dementia	26.4%
5	Huntington Disease	24.5%
6	Kluver-Bucy Syndrome	24.5%
7	Creutzfeldt-Jakob disease	24%
8	Dementia, Vascular	22.5%
9	Multiple System Atrophy	19.7%
10	Brain Diseases, Metabolic	18.6%
11	Prion Diseases	16.4%
12	AIDS Dementia Complex	16.3%
13	Meningoencephalitis	16.2%
14	Motor Neuron Disease	16%
15	Parkinson Disease	16%
16	Encephalomyelitis	15.8%
17	Subacute Combined Degeneration	14.7%
18	Subdural Effusion	14.5%
19	Dandy-Walker Syndrome	14.1%
20	Pneumocephalus	14%
21	Myelinolysis, Central Pontine	13.8%
22	Ocular Motility Disorders	13.7%
23	Cyclophoria	13.7%
24	Akinetic Mutism	13.2%
25	Anoxic Encephalopathy	13.2%
26	Basal Ganglia Diseases	13.2%
27	Brain Damage, Chronic	13.2%
28	Cerebellar Diseases	13.2%
29	Encephalitis	13.2%
30	Encephalomalacia	13.2%
31	Epilepsy	13.2%
32	Hydrocephalus	13.2%
33	Congenital Hydrocephalus	13.2%
34	Hypothalamic Diseases	13.2%
35	Thalamic Diseases	13.2%
36	Intracranial Hypertension	13.2%
37	Aura	13.2%
38	Leukoencephalopathy	13.2%
39	Neuroaxonal Dystrophies	13.2%
40	Headache Disorders	13.2%
41	Intracranial Hypotension	13.2%
42	Brain Edema	13.2%
43	Brain Hypoxia	13.2%
44	Aqueductal Stenosis	13.2%
45	Sleep Wake Disorders	13.1%
46	Spinal Muscular Atrophy	12.8%
47	Progressive Muscular Atrophy	12.8%
48	Tauopathies	12.7%
49	Brain Abscess	12.7%
50	Parkinsonian Disorders	12.4%
51	Dystonia Musculorum Deformans	12.3%
52	Hepatolenticular Degeneration	12.3%
53	Stiff-Person Syndrome	12.2%
54	Progressive supranuclear palsy	12.2%
55	Brain Injuries	12.1%
56	Meningitis	12.1%
57	Movement Disorders	12.1%
58	Pachymeningitis	12.1%
59	Spinal Cord Diseases	12.1%
60	Striatonigral Degeneration	12.1%
61	Brain Neoplasms	12%
62	Marchiafava-Bignami Disease	12%
63	Cranial nerve diseases	11.7%
64	Demyelinating Diseases	11.7%
65	Demyelination	11.7%
66	Neuromuscular Diseases	11.7%
67	Chronobiology Disorders	11.7%
68	Restless Legs Syndrome	11.6%
69	Basal Ganglia Cerebrovascular Disease	11.5%
70	Amnesia, Transient Global	11.5%
71	Epilepsy, Post-Traumatic	11.4%
72	Myelitis	11.4%
73	Amyloidosis	11.3%
74	Cerebrovascular Disorders	11.2%
75	Cerebrovascular Insufficiency	11.2%
76	Posterior Leukoencephalopathy Syndrome	11.2%
77	Posterior reversible encephalopathy syndrome	11.2%
78	Brain Diseases, Metabolic, Inborn	11.2%
79	Epidural Abscess	11.1%
80	Limbic Encephalitis	11%
81	Shy-Drager Syndrome	10.8%
82	Friedreich Ataxia	10.7%
83	Central Nervous System Infection	10.5%
84	Brain Death	10.4%
85	Neuroleptic Malignant Syndrome	10.3%
86	Canavan Disease	10.2%
87	Alexander Disease	10.2%
88	Meige Syndrome	10.2%
89	Cerebral Ventriculitis	10.2%
90	Leukomalacia, Periventricular	10.1%
91	Trauma, Nervous System	10.1%
92	Mitochondrial Encephalomyopathies	10.1%
93	Wasting Syndrome	9.9%
94	Nervous System Neoplasms	9.9%
95	Neurologic Manifestations	9.9%
96	Neurotoxicity Syndromes	9.9%
97	Amyloid Neuropathies, Familial	9.8%
98	Cognition Disorders	9.8%
99	Amblyopia	9.8%
100	Paraneoplastic Cerebellar Degeneration	9.7%
101	Ophthalmoplegic Migraine	9.7%
102	Spinal Cord Injuries	9.7%
103	Vascular Headaches	9.7%
104	Myelitis, Transverse	9.6%
105	Hypoxia-Ischemia, Brain	9.6%
106	Leukoencephalopathy, Progressive Multifocal	9.5%
107	Asterixis	9.4%
108	Ballismus	9.4%
109	Cerebellar Neoplasms	9.4%
110	Polyradiculoneuropathy	9.3%
111	Polyradiculoneuritis	9.3%
112	Reye Syndrome	9.3%
113	Opsoclonus-Myoclonus Syndrome	9.3%
114	Paraneoplastic Encephalomyelitis	9.2%
115	Hepatic Encephalopathy	9.2%
116	Progressive bulbar palsy	9.2%
117	Bulbar palsy	9.2%
118	Poliomyelitis	9.1%
119	Lafora Disease	9%
120	Unverricht-Lundborg Syndrome	9%
121	Myoclonic Epilepsy	9%
122	Epilepsy, Temporal Lobe	9%
123	Epilepsy, Rolandic	9%
124	Benign Rolandic Epilepsy	9%
125	Leukoencephalitis, Acute Hemorrhagic	8.9%
126	Acid-Base Imbalance	8.8%
127	Calcium Metabolism Disorders	8.8%
128	Iron Metabolism Disorders	8.8%
129	Phosphorus Metabolism Disorders	8.8%
130	Water-Electrolyte Imbalance	8.8%
131	Lipid Metabolism Disorders	8.8%
132	Mitochondrial Diseases	8.8%
133	Glucose Metabolism Disorders	8.8%
134	Lambert-Eaton Myasthenic Syndrome	8.7%
135	Lupus Vasculitis, Central Nervous System	8.6%
136	Chronic Fatigue Syndrome	8.5%
137	Wernicke Encephalopathy	8.5%
138	Consciousness Disorders	8.5%
139	Depressed Level of Consciousness	8.5%
140	Scrapie	8.4%
141	MPTP Poisoning	8.3%
142	Miller Fisher Syndrome	8.2%
143	Autonomic Dysreflexia	8.2%
144	Complex Regional Pain Syndromes	8.2%
145	Adrenoleukodystrophy	8.2%
146	Leigh Disease	8.2%
147	Hypercalcemia	8.1%
148	Hypocalcemia	8.1%
149	Milk-Alkali Syndrome	8.1%
150	Auditory Perceptual Disorders	8.1%
151	Refsum Disease	8%
152	Vasculitis, Central Nervous System	8%
153	Cerebral Palsy	8%
154	Epilepsies, Partial	8%
155	Epilepsy, Generalized	8%
156	Pseudotumor Cerebri	8%
157	Hypertensive Encephalopathy	8%
158	Simple Partial Seizures	8%
159	Epilepsy, Reflex	8%
160	Headache Disorders, Primary	8%
161	Headache Disorders, Secondary	8%
162	Medication overuse headache	8%
163	Parasomnia	8%
164	Dyssomnias	8%
165	Neurotic Disorders	7.9%
166	Encephalomyelitis, Acute Disseminated	7.9%
167	Meningitis, Bacterial	7.9%
168	Meningitis, Fungal	7.9%
169	MELAS Syndrome	7.8%
170	Cerebral Amyloid Angiopathy	7.8%
171	Ataxia Telangiectasia	7.7%
172	Sleep Disorders, Circadian Rhythm	7.6%
173	Brain Hemorrhage, Traumatic	7.6%
174	Amnesia	7.5%
175	Delirium	7.5%
176	Dissociative Amnesia	7.5%
177	Global Amnesia	7.5%
178	Basal Ganglia Hemorrhage	7.5%
179	Osteopenia	7.5%
180	Spinal Cord Neoplasms	7.4%
181	Akathisia, Drug-Induced	7.3%
182	Brain Injuries, Diffuse	7.3%
183	Traumatic Brain Injury	7.3%
184	Cerebellar Ataxia	7.3%
185	Supratentorial Neoplasms	7.3%
186	Carotid Artery Injuries	7.3%
187	Peripheral Nerve Injuries	7.1%
188	Dyskinesia, Drug-Induced	7.1%
189	Galactosemias	7.1%
190	Urea Cycle Disorders, Inborn	7.1%
191	Tyrosinemias	7.1%
192	Myasthenia Gravis	7%
193	Pseudohypoparathyroidism	7%
194	Lipodystrophy	7%
195	Pituitary Diseases	6.9%
196	Pituitary Adenoma	6.9%
197	Pituitary Neoplasms	6.9%
198	Juvenile Myoclonic Epilepsy	6.9%
199	Myoclonic Epilepsies, Progressive	6.9%
200	Toxoplasmosis, Cerebral	6.9%
201	Pituitary Apoplexy	6.9%
202	Guillain-Barre Syndrome	6.8%
203	Persistent Vegetative State	6.8%
204	Neuronal Ceroid-Lipofuscinoses	6.8%
205	Brain Infarction	6.8%
206	Arachnoiditis	6.8%
207	Aseptic Meningitis	6.8%
208	Syringomyelia	6.8%
209	Essential Tremor	6.8%
210	Familial Tremor	6.8%
211	Pneumorrhachis	6.8%
212	Writer's Cramp	6.8%
213	Carotid Artery Diseases	6.7%
214	Brain Ischemia	6.7%
215	Cerebrovascular accident	6.7%
216	Vasospasm, Intracranial	6.7%
217	Intracranial Arterial Diseases	6.7%
218	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.7%
219	Kernicterus	6.6%
220	Rickets	6.4%
221	Tuberous Sclerosis	6.3%
222	Cockayne Syndrome	6.2%
223	Dysautonomia	6.2%
224	Vagus Nerve Disorder	6.2%
225	Glossopharyngeal Neuralgia	6.2%
226	Abducens Nerve Diseases	6.2%
227	Heavy Metal Poisoning, Nervous System	6.2%
228	Neuromuscular Junction Diseases	6.2%
229	Trochlear Nerve Diseases	6.2%
230	Peripheral Nervous System Diseases	6.2%
231	Botulism	6.1%
232	Central Nervous System Cysts	6.1%
233	Mitochondrial Myopathies	6.1%
234	Myotonia Congenita	6.1%
235	Anxiety Disorders	6%
236	Avoidant Personality Disorder	6%
237	Dissociative disorder	6%
238	Frigidity	6%
239	Hypoactive Sexual Desire Disorder	6%
240	Disruptive, Impulse Control, and Conduct Disorders	6%
241	Intermittent Explosive Disorder	6%
242	Kleptomania	6%
243	Narcissistic Personality Disorder	6%
244	Personality Disorders	6%
245	Sexual Aversion Disorder	6%
246	Somatoform Disorder	6%
247	Dissociation	6%
248	Motor Disorders	6%
249	Mood Disorders	6%
250	Schizophrenia Spectrum and Other Psychotic Disorders	6%
251	Neurodevelopmental Disorders	6%
252	Feeding and Eating Disorders	6%
253	Homocystinuria	6%
254	Olfactory Nerve Injuries	5.9%
255	Putaminal Hemorrhage	5.9%
256	Neuromyelitis Optica	5.8%
257	Causalgia	5.8%
258	Intracranial Embolism and Thrombosis	5.8%
259	Central Nervous System Fungal Infections	5.7%
260	Conus Medullaris Syndrome	5.7%
261	Spinal Cord Vascular Diseases	5.7%
262	Nutrition Disorders	5.7%
263	Menkes Kinky Hair Syndrome	5.6%
264	Central Cord Syndrome	5.6%
265	Infarction, Middle Cerebral Artery	5.5%
266	Infarction, Anterior Cerebral Artery	5.5%
267	Infarction, Posterior Cerebral Artery	5.5%
268	Charcot-Marie-Tooth Disease	5.5%
269	Chorea	5.5%
270	Separation Anxiety Disorder	5.5%
271	Tuberculosis, Meningeal	5.5%
272	Jet Lag Syndrome	5.5%
273	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.5%
274	Post-Traumatic Headache	5.4%
275	Tension Headache	5.4%
276	Epilepsy, Complex Partial	5.4%
277	Migraine Disorders	5.4%
278	Abdominal Migraine	5.4%
279	Status Migrainosus	5.4%
280	Cervicogenic Headache	5.4%
281	Myopathy	5.4%
282	Optic Neuropathy	5.4%
283	Moyamoya Disease	5.3%
284	Horner Syndrome	5.3%
285	Facial Nerve Diseases	5.2%
286	Craniocerebral Trauma	5.2%
287	Facial Nerve Injuries	5.2%
288	Drug abuse	5.2%
289	Substance Dependence	5.2%
290	Substance-Related Disorders	5.2%
291	Drug Dependence	5.2%
292	Vestibulocochlear Nerve Diseases	5.2%
293	Decerebrate State	5.2%
294	Hemiparesis	5.2%
295	Hydranencephaly	5.2%
296	Meningism	5.2%
297	Neural Tube Defects	5.2%
298	Paresis	5.2%
299	Seizures	5.2%
300	Sensation Disorders	5.2%
301	Tethered Cord Syndrome	5.2%
302	Central Nervous System Neoplasms	5.2%
303	Complex partial seizures	5.2%
304	Iniencephaly	5.2%
305	Craniorachischisis	5.2%
306	Exencephaly	5.2%
307	Monoparesis	5.2%
308	Septo-Optic Dysplasia	5.2%
309	Cortical Dysplasia	5.2%
310	Neurogenic Inflammation	5.2%
311	Gait Disorders, Neurologic	5.2%
312	Neuromuscular Manifestations	5.2%
313	Malformations of Cortical Development	5.2%
314	Myotonic Dystrophy	5.2%
315	Cerebral Infarction	5.2%
316	Brain Stem Infarctions	5.2%
317	Fabry Disease	5.2%
318	Sweating, Gustatory	5.2%
319	Auriculotemporal Syndrome	5.2%
320	Optic Atrophy, Hereditary, Leber	5.1%
321	Hyperhomocysteinemia	5.1%
322	Zellweger Syndrome	5.1%
323	Multiple Sclerosis	5.1%
324	Vertebral Artery Dissection	5%
325	Diffuse Axonal Injury	5%
326	Brain Stem Neoplasms	5%
327	Central Nervous System Bacterial Infections	5%
328	Alexia, Pure	4.9%
329	Glycogen storage disease type II	4.9%
330	Acidosis	4.8%
331	Alkalosis	4.8%
332	Calcinosis	4.8%
333	Hyperglycemia	4.8%
334	Hyperinsulinism	4.8%
335	Hyperkalemia	4.8%
336	Hypernatremia	4.8%
337	Hypoglycemia	4.8%
338	Hypokalemia	4.8%
339	Hyponatremia	4.8%
340	Lactose Intolerance	4.8%
341	Reflex Sympathetic Dystrophy	4.8%
342	Xanthomatosis	4.8%
343	Hypophosphatemia	4.8%
344	Metabolic acidosis	4.8%
345	Dyslipidemias	4.8%
346	Iron Overload	4.8%
347	Xanthoma	4.8%
348	Nocturnal Myoclonus Syndrome	4.8%
349	Subarachnoid Hemorrhage, Traumatic	4.8%
350	Carotid Artery, Internal, Dissection	4.8%
351	Myasthenia Gravis, Autoimmune, Experimental	4.7%
352	Brain Concussion	4.7%
353	Retrograde amnesia	4.6%
354	Amnesia, Anterograde	4.6%
355	Tetany	4.6%
356	Empty Sella Syndrome	4.6%
357	Hyperpituitarism	4.6%
358	Hypopituitarism	4.6%
359	Hypophysitis	4.6%
360	Sleep Talking	4.6%
361	Sleep Disorders, Intrinsic	4.6%
362	Subacute Sclerosing Panencephalitis	4.6%
363	Pupil Disorders	4.6%
364	Neurobehavioral Manifestations	4.6%
365	Torticollis	4.6%
366	Cerebral Arterial Diseases	4.5%
367	Vertebrobasilar Insufficiency	4.5%
368	Basilar Artery Stenosis	4.5%
369	Vertebral Artery Stenosis	4.5%
370	Intracranial Hemorrhage, Hypertensive	4.5%
371	Transient Cerebral Ischemia	4.5%
372	Ophthalmoplegia	4.5%
373	External Ophthalmoplegia	4.5%
374	Uveomeningoencephalitic Syndrome	4.5%
375	Sturge-Weber Syndrome	4.4%
376	Vertigo	4.4%
377	Alcohol-Induced Disorders, Nervous System	4.4%
378	Meningitis, Cryptococcal	4.4%
379	Meningitis, Listeria	4.4%
380	Brain Contusion	4.4%
381	Meningitis, Haemophilus	4.4%
382	Meningitis, Pneumococcal	4.4%
383	Lateral Medullary Syndrome	4.4%
384	Smith-Lemli-Opitz Syndrome	4.4%
385	Mental Retardation	4.3%
386	Mental deficiency	4.3%
387	Intellectual Disability	4.3%
388	Alice in Wonderland Syndrome	4.3%
389	Primary amyloidosis	4.3%
390	Gaucher Disease	4.3%
391	Diabetes Mellitus	4.2%
392	Cluster Headache	4.1%
393	Migraine with Aura	4.1%
394	Familial Hemiplegic Migraine	4.1%
395	Chronic Paroxysmal Hemicrania	4.1%
396	SUNCT Syndrome	4.1%
397	Paroxysmal Hemicrania	4.1%
398	Acrodynia	4.1%
399	Hypolipoproteinemias	4.1%
400	Kearns-Sayre syndrome	4.1%
401	Giant Cell Arteritis	4.1%
402	Temporal Arteritis	4.1%
403	Dehydration	4.1%
404	Lipomatosis	4.1%
405	Water Intoxication	4.1%
406	Werner Syndrome	4.1%
407	Familial Periodic Paralysis	4.1%
408	Achlorhydria	4.1%
409	Amino Acid Metabolism, Inborn Errors	4.1%
410	Bloom Syndrome	4.1%
411	Carbohydrate Metabolism, Inborn Errors	4.1%
412	Metal Metabolism, Inborn Errors	4.1%
413	Osteoporosis	4.1%
414	Progeria	4.1%
415	Lysosomal Storage Diseases	4.1%
416	Bone Demineralization, Pathologic	4.1%
417	Cytochrome-c Oxidase Deficiency	4.1%
418	Peroxisomal Disorders	4.1%
419	Post-Traumatic Osteoporosis	4.1%
420	Vocal Cord Paralysis	4%
421	Celiac Disease	4%
422	Sprue, Tropical	4%
423	Steatorrhea	4%
424	Sprue	4%
425	Voice Disorders	4%
426	Voice Disturbance	4%
427	Sleep Bruxism	4%
428	Hyperphosphaturia	3.9%
429	Smith-Magenis syndrome	3.9%
430	Carotid Stenosis	3.9%
431	Intracranial Aneurysm	3.9%
432	Dural Arteriovenous Fistula	3.9%
433	Intracranial Arteriosclerosis	3.9%
434	Cerebral Atherosclerosis	3.9%
435	Subarachnoid Hemorrhage	3.9%
436	Cerebral Arteriosclerosis	3.9%
437	Cerebral Hemorrhage	3.9%
438	Cerebral Thrombosis	3.9%
439	Intracranial Embolism	3.9%
440	Intracranial Thrombosis	3.9%
441	Alstrom Syndrome	3.9%
442	Choroid Plexus Papilloma	3.9%
443	Osteomalacia	3.9%
444	Brachial Plexus Neuritis	3.7%
445	Neuralgic Amyotrophy	3.7%
446	Alcohol Withdrawal Delirium	3.7%
447	Congenital Hyperinsulinism	3.7%
448	Familial Hypophosphatemic Rickets	3.7%
449	Tardive Dyskinesia	3.7%
450	Cerebrospinal Fluid Otorrhea	3.6%
451	Cerebrospinal Fluid Rhinorrhea	3.6%
452	Neuritis, Autoimmune, Experimental	3.6%
453	Gait Ataxia	3.6%
454	HIV Wasting Syndrome	3.6%
455	Hyperlipoproteinemia Type IV	3.6%
456	Hyperlipoproteinemia Type V	3.6%
457	Alcohol Withdrawal Seizures	3.6%
458	Neuritis	3.5%
459	Polyneuritis	3.5%
460	Radiculitis	3.5%
461	Polyneuropathy	3.5%
462	Mononeuritis	3.5%
463	Mononeuropathies	3.5%
464	Brachial Plexus Neuropathies	3.5%
465	Radiculopathy	3.5%
466	Mononeuropathy Multiplex	3.5%
467	Nerve Root Compression	3.5%
468	Spinal Cord Ischemia	3.5%
469	Hyperprolactinemia	3.5%
470	Glycosuria	3.5%
471	Tuberculosis, Central Nervous System	3.5%
472	Coma, Post-Head Injury	3.5%
473	Sleep Deprivation	3.5%
474	Subclavian Steal Syndrome	3.5%
475	Diabetic Ketoacidosis	3.4%
476	Reflex, Abnormal	3.4%
477	Hyporeflexia	3.4%
478	Hyperreflexia	3.4%
479	Hyperlipidemia, Familial Combined	3.4%
480	Carotid Artery Thrombosis	3.4%
481	West Nile Fever	3.4%
482	Psychoses, Substance-Induced	3.3%
483	Niemann-Pick Disease, Type C	3.3%
484	Adjustment Disorders	3.3%
485	Affective Disorders, Psychotic	3.3%
486	Agoraphobia	3.3%
487	Anorexia Nervosa	3.3%
488	Antisocial Personality Disorder	3.3%
489	Bipolar Disorder	3.3%
490	Body Dysmorphic Disorders	3.3%
491	Borderline Personality Disorder	3.3%
492	Brain Diseases	3.3%
493	Capgras Syndrome	3.3%
494	Child Behavior Disorders	3.3%
495	Developmental Disabilities	3.3%
496	Child Development Disorders, Pervasive	3.3%
497	Claustrophobia	3.3%
498	Conversion disorder	3.3%
499	Cyclothymic Disorder	3.3%
500	Dependent Personality Disorder	3.3%
501	Depressive disorder	3.3%
502	Developmental Coordination Disorder	3.3%
503	Exhibitionism	3.3%
504	Factitious Disorders	3.3%
505	Firesetting Behavior	3.3%
506	Head Banging	3.3%
507	Histrionic Personality Disorder	3.3%
508	Hypochondriasis	3.3%
509	Masochism	3.3%
510	Melancholia	3.3%
511	Motor Skills Disorders	3.3%
512	Dissociative Identity Disorder	3.3%
513	Neurasthenia	3.3%
514	Obsessive-Compulsive Disorder	3.3%
515	Oppositional Defiant Disorder	3.3%
516	Panic Disorder	3.3%
517	Paranoid Personality Disorder	3.3%
518	Pedophilia	3.3%
519	Pseudodementia	3.3%
520	Psychotic Disorders	3.3%
521	Sadism	3.3%
522	Schizoaffective Disorder	3.3%
523	Schizoid Personality Disorder	3.3%
524	Schizophrenia	3.3%
525	Schizophrenia, Childhood	3.3%
526	Schizotypal Personality Disorder	3.3%
527	Stereotypic Movement Disorder	3.3%
528	Transvestism	3.3%
529	Trichotillomania	3.3%
530	Voyeurism	3.3%
531	Attention Deficit and Disruptive Behavior Disorders	3.3%
532	Hyperkinetic Heart Syndrome	3.3%
533	Reactive Attachment Disorder	3.3%
534	Sexual and Gender Disorders	3.3%
535	Gender Dysphoria	3.3%
536	Paranoia	3.3%
537	Compulsive Personality Disorder	3.3%
538	Bulimia Nervosa	3.3%
539	Tay-Sachs Disease	3.2%
540	Akathisia	3.2%
541	Restlessness	3.2%
542	Psychomotor Agitation	3.2%
543	Mutism	3.2%
544	Selective Mutism	3.2%
545	Renal tubular acidosis	3.2%
546	Multiple Sclerosis, Chronic Progressive	3.2%
547	Multiple Sclerosis, Relapsing-Remitting	3.2%
548	Hematoma, Subdural	3.2%
549	Hematoma, Epidural, Cranial	3.2%
550	Tarsal Tunnel Syndrome	3.2%
551	Cauda Equina Syndrome	3.2%
552	Porphyrias, Hepatic	3.1%
553	Hyperlipoproteinemia Type III	3.1%
554	Necrobiosis Lipoidica Diabeticorum	3%
555	Fanconi Anemia	3%
556	Neuroaspergillosis	3%
557	Myositis	3%
558	Optic Atrophy	3%
559	Optic Neuritis	3%
560	Papilledema	3%
561	Strabismus	3%
562	Tolosa-Hunt Syndrome	3%
563	Isaacs syndrome	3%
564	Arsenic Poisoning	3%
565	Myotonic Disorders	3%
566	Myasthenic Syndromes, Congenital	3%
567	Acromegaly	3%
568	Diabetic Neuropathies	3%
569	Facial Injuries	3%
570	Facial Neuralgia	3%
571	Diabetic Amyotrophy	3%
572	Diabetic Autonomic Neuropathy	3%
573	Manganese Poisoning	3%
574	Orthostatic intolerance	3%
575	Optic Nerve Glioma	3%
576	Anosmia	3%
577	Ataxia	3%
578	Athetosis	3%
579	Catalepsy	3%
580	Dystonia	3%
581	Hemiplegia	3%
582	Locked-In Syndrome	3%
583	Meningeal Neoplasms	3%
584	Meningomyelocele	3%
585	Muscle Hypertonia	3%
586	Muscle hypotonia	3%
587	Myoclonus	3%
588	Myotonia	3%
589	Neuralgia	3%
590	Paraplegia	3%
591	Pseudobulbar Palsy	3%
592	Quadriplegia	3%
593	Spasm	3%
594	Spastic Paraplegia	3%
595	Status Epilepticus	3%
596	Taste Disorders	3%
597	Tremor	3%
598	Spina Bifida	3%
599	Monoplegia	3%
600	Hypokinesia	3%
601	Paraparesis	3%
602	Bradykinesia	3%
603	Waxy flexibility	3%
604	Action Tremor	3%
605	Resting Tremor	3%
606	Dysosmia	3%
607	Quadriparesis	3%
608	Mercury Poisoning, Nervous System	3%
609	Olfaction Disorders	3%
610	Myokymia	3%
611	Lead Poisoning, Nervous System	3%
612	Vestibular Neuronitis	3%
613	Somatosensory Disorders	3%
614	Neuropathic pain	3%
615	Hyperkinesia	3%
616	Intention tremor	3%
617	Sinus Thrombosis, Intracranial	3%
618	Child Nutrition Disorders	2.9%
619	Disorders of Excessive Somnolence	2.9%
620	Hypervitaminosis A	2.9%
621	Infant Nutrition Disorders	2.9%
622	Sleep Initiation and Maintenance Disorders	2.9%
623	Night Terrors	2.9%
624	Somnambulism	2.9%
625	Malnutrition	2.9%
626	Transient Insomnia	2.9%
627	Sleep Paralysis	2.9%
628	Chronic Insomnia	2.9%
629	REM Sleep Behavior Disorder	2.9%
630	Hypersomnia	2.9%
631	HIV-Associated Lipodystrophy Syndrome	2.9%
632	Acidosis, Lactic	2.9%
633	Calciphylaxis	2.9%
634	Hemosiderosis	2.9%
635	Ketosis	2.9%
636	Ketonuria	2.9%
637	Ketoacidosis	2.9%
638	Ketonemia	2.9%
639	Vascular calcification	2.9%
640	Gait Apraxia	2.9%
641	Alexia	2.8%
642	Dyslexia	2.8%
643	Renal Osteodystrophy	2.8%
644	Renal rickets	2.8%
645	Marijuana Abuse	2.8%
646	Opioid-Related Disorders	2.8%
647	Nicotine Dependence	2.8%
648	Opioid abuse	2.8%
649	Phencyclidine Abuse	2.8%
650	Substance Abuse, Intravenous	2.8%
651	Substance Withdrawal Syndrome	2.8%
652	Tobacco Use Disorder	2.8%
653	Alcohol-Related Disorders	2.8%
654	Amphetamine-Related Disorders	2.8%
655	Cocaine-Related Disorders	2.8%
656	Carpal Tunnel Syndrome	2.8%
657	neurofibroma	2.7%
658	Sciatica	2.7%
659	Acoustic Neuroma	2.7%
660	Hypoalphalipoproteinemias	2.7%
661	Gambling	2.7%
662	Premature Ejaculation	2.7%
663	Erectile dysfunction	2.7%
664	Pseudorabies	2.7%
665	Hand-Arm Vibration Syndrome	2.7%
666	Glycosuria, Renal	2.6%
667	Vision Disorders	2.6%
668	Metamorphopsia	2.6%
669	Visual Impairment	2.6%
670	Neurosyphilis	2.6%
671	Hypokalemic periodic paralysis	2.6%
672	Fibromyalgia	2.6%
673	Optic Neuropathy, Ischemic	2.6%
674	Anterior Ischemic Optic Neuropathy	2.6%
675	Medial Tibial Stress Syndrome	2.6%
676	Facial Hemiatrophy	2.6%
677	Melkersson-Rosenthal Syndrome	2.6%
678	Anisocoria	2.6%
679	Confusion	2.6%
680	Facial paralysis	2.6%
681	Lethargy	2.6%
682	Memory Disorders	2.6%
683	Muscle Cramp	2.6%
684	Perceptual Disorders	2.6%
685	Psychomotor Disorders	2.6%
686	Tonic Pupil	2.6%
687	Eosinophilia-Myalgia Syndrome	2.6%
688	Anhedonia	2.6%
689	Disorientation	2.6%
690	Facial Paresis	2.6%
691	Memory Loss	2.6%
692	Hemisensory Neglect	2.6%
693	Dysacusis	2.6%
694	Anencephaly	2.5%
695	Meningocele	2.5%
696	Muscular Atrophy	2.5%
697	Respiratory Paralysis	2.5%
698	Encephalocele	2.5%
699	Hematoma, Subdural, Intracranial	2.5%
700	Hematoma, Subdural, Chronic	2.5%
701	Hematoma, Subdural, Acute	2.5%
702	Dyscalculia	2.5%
703	Cavernous Sinus Thrombosis	2.5%
704	Sagittal Sinus Thrombosis	2.5%
705	Acidosis, Respiratory	2.4%
706	Adiposis Dolorosa	2.4%
707	Alkalosis, Respiratory	2.4%
708	Nesidioblastosis	2.4%
709	Alkaptonuria	2.4%
710	Glycogen Storage Disease	2.4%
711	Hypophosphatasia	2.4%
712	Insulin Resistance	2.4%
713	Osteoporosis, Postmenopausal	2.4%
714	Propionic acidemia	2.4%
715	Dihydropyrimidine Dehydrogenase Deficiency	2.4%
716	Cystinosis	2.4%
717	Anterior Spinal Artery Syndrome	2.4%
718	Neonatal Abstinence Syndrome	2.4%
719	Dyspareunia	2.3%
720	Prolactinoma	2.3%
721	Growth Hormone-Secreting Pituitary Adenoma	2.3%
722	Lyme Neuroborreliosis	2.3%
723	Cubital Tunnel Syndrome	2.3%
724	Duane Retraction Syndrome	2.3%
725	Muscle Weakness	2.3%
726	Mucopolysaccharidosis II	2.3%
727	Mobius Syndrome	2.3%
728	Bell Palsy	2.3%
729	Catatonia	2.3%
730	Herpes Zoster Oticus	2.2%
731	Sciatic Neuropathy	2.2%
732	Ulnar Neuropathies	2.2%
733	Lesion of Sciatic Nerve	2.2%
734	Ulnar Neuritis	2.2%
735	Radial nerve compression	2.2%
736	Radial Tunnel Syndrome	2.2%
737	Peroneal Neuropathies	2.2%
738	Radial Neuropathy	2.2%
739	Median Neuropathy	2.2%
740	Sciatic Nerve Palsy	2.2%
741	Femoral Neuropathy	2.2%
742	Tibial Neuropathy	2.2%
743	Ulnar Nerve Palsy	2.2%
744	Postural Orthostatic Tachycardia Syndrome	2.2%
745	Radial nerve palsy	2.2%
746	Aphonia	2.2%
747	Dysphonia	2.2%
748	Nelson Syndrome	2.2%
749	Classical Lissencephalies and Subcortical Band Heterotopias	2.1%
750	Mucopolysaccharidosis III	2.1%
751	Narcolepsy	2.1%
752	Kleine-Levin Syndrome	2.1%
753	Gestational Diabetes	2.1%
754	Latent Autoimmune Diabetes in Adults	2.1%
755	Diabetes Mellitus, Experimental	2.1%
756	Toxoplasmosis, Congenital	2.1%
757	Malaria, Cerebral	2.1%
758	Nephrocalcinosis	2.1%
759	Xeroderma Pigmentosum	2.1%
760	Neurocysticercosis	2.1%
761	Enuresis	2%
762	Psychoses, Alcoholic	2%
763	Myalgia	2%
764	Waterhouse-Friderichsen Syndrome	2%
765	Combat Disorders	1.9%
766	Dysthymic Disorder	1.9%
767	Hysteria	1.9%
768	Schizophrenia, Catatonic	1.9%
769	Schizophrenia, Disorganized	1.9%
770	Post-Traumatic Stress Disorder	1.9%
771	Attention Deficit Disorder	1.9%
772	Seasonal Affective Disorder	1.9%
773	Conduct Disorder	1.9%
774	Social Communication Disorder	1.9%
775	Psychological Trauma	1.9%
776	Hoarding Disorder	1.9%
777	Phonological Disorder	1.9%
778	Hypercholesterolemia	1.9%
779	Hyperlipoproteinemias	1.9%
780	Hypertriglyceridemia	1.9%
781	Thoracic Outlet Syndrome	1.9%
782	Esotropia	1.9%
783	Exotropia	1.9%
784	Hypotension, Orthostatic	1.9%
785	Sleep Apnea Syndromes	1.9%
786	Polymyositis	1.9%
787	Post-Exercise Hypotension	1.9%
788	Trigeminal Nerve Disorder	1.9%
789	Dermal Sinus	1.9%
790	Dysgeusia	1.9%
791	Formication	1.9%
792	Hyperalgesia	1.9%
793	Hyperesthesia	1.9%
794	Hypesthesia	1.9%
795	Language Disorders	1.9%
796	Numbness	1.9%
797	Paresthesia	1.9%
798	Paraparesis, Spastic	1.9%
799	Spina Bifida Cystica	1.9%
800	Trismus	1.9%
801	Spina Bifida Occulta	1.9%
802	Epilepsia Partialis Continua	1.9%
803	Hypogeusia	1.9%
804	Meningeal Carcinomatosis	1.9%
805	Brown-Sequard Syndrome	1.9%
806	Lissencephaly	1.9%
807	Polymicrogyria	1.9%
808	Pachygyria	1.9%
809	Schizencephaly	1.9%
810	Lockjaw	1.9%
811	Allodynia	1.9%
812	Lead Poisoning, Nervous System, Childhood	1.9%
813	Lead Poisoning, Nervous System, Adult	1.9%
814	Periventricular Nodular Heterotopia	1.9%
815	Ageusia	1.9%
816	Sjogren-Larsson Syndrome	1.9%
817	Aicardi's syndrome	1.8%
818	Variegate Porphyria	1.8%
819	Acute intermittent porphyria	1.8%
820	Porphyria Cutanea Tarda	1.8%
821	Hoarseness	1.8%
822	Prader-Willi Syndrome	1.8%
823	Renal Aminoacidurias	1.8%
824	Fanconi Syndrome	1.8%
825	Pseudohypoaldosteronism	1.8%
826	Liddle Syndrome	1.8%
827	Cataplexy	1.7%
828	Eye Injuries	1.7%
829	Dementia	1.6%
830	Gout	1.6%
831	Muscular Dystrophy	1.6%
832	Congenital nystagmus	1.6%
833	Orbital Myositis	1.6%
834	Holoprosencephaly	1.6%
835	Diplopia	1.6%
836	Muscle Rigidity	1.6%
837	Muscle Spasticity	1.6%
838	Scotoma	1.6%
839	Photophobia	1.6%
840	Cogwheel Rigidity	1.6%
841	Hemifacial Spasm	1.6%
842	Amaurosis	1.6%
843	Blindness	1.6%
844	Nuchal Rigidity	1.6%
845	Alcohol Use Disorder	1.6%
846	Alcoholic Intoxication	1.6%
847	Heroin Dependence	1.6%
848	Morphine Dependence	1.6%
849	Alcohol abuse	1.6%
850	Depression, Postpartum	1.6%
851	Pyomyositis	1.6%
852	Deficiency Diseases	1.6%
853	Starvation	1.6%
854	Premenstrual Dysphoric Disorder	1.6%
855	Refeeding Syndrome	1.6%
856	Antley-Bixler Syndrome Phenotype	1.6%
857	Agnosia	1.6%
858	Apraxias	1.6%
859	Hallucinations	1.6%
860	Hemianopsia	1.6%
861	Hyperacusis	1.6%
862	Tinnitus	1.6%
863	Visual Agnosia	1.6%
864	Anosognosia	1.6%
865	Wernicke-Korsakoff Syndrome	1.6%
866	Phonophobia	1.6%
867	Hearing Loss	1.6%
868	Sarcopenia	1.6%
869	Polyradiculopathy	1.6%
870	Glycogen Storage Disease Type I	1.6%
871	Glycogen Storage Disease Type V	1.6%
872	Neurofibrosarcoma	1.6%
873	CREST Syndrome	1.4%
874	Color blindness	1.4%
875	Cri-du-Chat Syndrome	1.4%
876	Down Syndrome	1.4%
877	Trisomy 21	1.4%
878	POEMS Syndrome	1.4%
879	Meningioma	1.4%
880	Williams Syndrome	1.4%
881	Microcephaly	1.4%
882	Macrocephaly	1.4%
883	Porencephaly	1.4%
884	Binge Drinking	1.4%
885	Albinism	1.3%
886	Sleep Apnea, Obstructive	1.3%
887	Sleep Apnea, Central	1.3%
888	Trigeminal Neuralgia	1.3%
889	Agraphia	1.3%
890	Anomia	1.3%
891	Cluttering	1.3%
892	Language Development Disorders	1.3%
893	Speech Disorders	1.3%
894	Syncope	1.3%
895	Stupor	1.3%
896	Dysgraphia	1.3%
897	Presyncope	1.3%
898	Dyslalia	1.3%
899	Autistic Disorder	1.3%
900	Asperger Syndrome	1.3%
901	Phantom pain	1.3%
902	Phantom Limb Pain	1.3%
903	Diurnal Enuresis	1.2%
904	Frontotemporal dementia	1.2%
905	Cystinuria	1.2%
906	Eye Burns	1.2%
907	Welander Distal Myopathy	1.1%
908	Amaurosis Fugax	1.1%
909	Blindness, Cortical	1.1%
910	Rett Syndrome	1.1%
911	Deafness	1.1%
912	Hearing Loss, Sudden	1.1%
913	Gerstmann Syndrome	1.1%
914	Hearing Loss, Bilateral	1.1%
915	Hearing Loss, High-Frequency	1.1%
916	Hearing Loss, Mixed Conductive-Sensorineural	1.1%
917	Prosopagnosia	1.1%
918	Apraxia, Ideomotor	1.1%
919	Charles Bonnet Syndrome	1.1%
920	Hearing Loss, Unilateral	1.1%
921	Complete Hearing Loss	1.1%
922	Alien Hand Syndrome	1.1%
923	Deaf Mutism	1.1%
924	Ichthyosis, X-Linked	1.1%
925	Arthritis, Gouty	1.1%
926	Aphasia	1.1%
927	Articulation Disorders	1.1%
928	Echolalia	1.1%
929	Stuttering	1.1%
930	Dysphasia	1.1%
931	Rubinstein-Taybi Syndrome	1%
932	Dermatomyositis	1%
933	Corneal Scar	1%
934	Muscular Dystrophy, Duchenne	1%
935	Obesity	1%
936	Kwashiorkor	1%
937	Magnesium Deficiency	1%
938	Potassium Deficiency	1%
939	Protein Deficiency	1%
940	Avitaminosis	1%
941	Dysarthria	0.9%
942	Fragile X Syndrome	0.9%
943	Corneal Perforation	0.8%
944	Obesity, Abdominal	0.7%
945	Pick Disease of the Brain	0.7%
946	Ascorbic Acid Deficiency	0.6%
947	Vitamin A Deficiency	0.6%
948	Vitamin D Deficiency	0.6%
949	Vitamin E Deficiency	0.6%
950	Marasmus	0.6%
951	Pediatric Obesity	0.6%
952	Folic Acid Deficiency	0.5%
953	Pellagra	0.5%
954	Thiamine Deficiency	0.5%
955	Vitamin B 12 Deficiency	0.5%
956	Vitamin B 6 Deficiency	0.5%
957	Pyridoxine Deficiency	0.5%
958	Vitamin K Deficiency	0.5%
959	Beriberi	0.4%
960	Scurvy	0.3%
961	Anemia, Pernicious	0.3%

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