MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Central Nervous System Fungal Infections

(UMLS:C0729544)

Definition:: MYCOSES of the brain, spinal cord, and meninges which may result in ENCEPHALITIS; MENINGITIS, FUNGAL; MYELITIS; BRAIN ABSCESS; and EPIDURAL ABSCESS. Certain types of fungi may produce disease in immunologically normal hosts, while others are classified as opportunistic pathogens, causing illness primarily in immunocompromised individuals (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME).
UMLS ID:: C0729544
MeSH ID:: D020314

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.703.181

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.228.198

Synonym(s)

Central Nervous System Fungal Infections

Central nervous system fungal infection

Fungal central nervous system infection

Fungal infection of central nervous system

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Prednisone		4711275	CTD
2	posaconazole		12032903	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Encephalomyelitis	39.7%
2	Meningoencephalitis	38.9%
3	Epidural Abscess	36.7%
4	Myelitis	33.9%
5	Central Nervous System Bacterial Infections	30.6%
6	Brain Abscess	29.9%
7	Prion Diseases	29.3%
8	Aspergillosis	27.9%
9	Candidiasis	27.9%
10	Coccidioidomycosis	27.9%
11	Histoplasmosis	27.9%
12	Paracoccidioidomycosis	27.9%
13	Zygomycosis	27.9%
14	Phaeohyphomycosis	27.9%
15	Pneumocystis Infections	27.9%
16	Subdural Effusion	27.7%
17	Meningitis, Bacterial	26.2%
18	Cerebral Ventriculitis	25%
19	Tuberculosis, Meningeal	24.7%
20	Neuroaspergillosis	24.2%
21	Candidemia	23.4%
22	Candidiasis, Chronic Mucocutaneous	22.8%
23	Cutaneous Candidiasis	22.8%
24	Invasive Pulmonary Aspergillosis	22%
25	Toxoplasmosis, Cerebral	21.2%
26	Otomycosis	21.1%
27	Brain Diseases	20.9%
28	Meningitis	20.9%
29	Movement Disorders	20.9%
30	Pachymeningitis	20.9%
31	Spinal Cord Diseases	20.9%
32	Tuberculosis, Central Nervous System	20.9%
33	Piedra	20.7%
34	Dermatomycoses	20.5%
35	Mucormycosis	20.5%
36	Poliomyelitis	20.1%
37	Creutzfeldt-Jakob disease	20%
38	Meningitis, Listeria	20%
39	Neurosyphilis	19.8%
40	Meningitis, Haemophilus	19.7%
41	Meningitis, Pneumococcal	19.7%
42	Lyme Neuroborreliosis	19%
43	Parkinsonian Disorders	17.6%
44	Multiple System Atrophy	17.5%
45	Ocular Motility Disorders	17.4%
46	Cyclophoria	17.4%
47	Leukoencephalopathy, Progressive Multifocal	17.3%
48	Blastomycosis	17.1%
49	Scrapie	17%
50	Lung Diseases, Fungal	16.9%
51	Pneumocephalus	16.8%
52	Lupus Vasculitis, Central Nervous System	16.7%
53	Limbic Encephalitis	16.1%
54	Fungemia	16.1%
55	Oral candidiasis	15.5%
56	Subacute Sclerosing Panencephalitis	15.4%
57	Chromoblastomycosis	15.3%
58	Dermatophytosis	15.3%
59	Sporotrichosis	15.3%
60	Tinea	15.3%
61	Tinea Versicolor	15.3%
62	Trichophytosis	15.3%
63	Hyalohyphomycosis	15.3%
64	Pulmonary Aspergillosis	15.3%
65	Bronchopulmonary Aspergillosis	15.3%
66	Parkinson Disease	15.2%
67	Lewy Body Disease	15%
68	Meige Syndrome	15%
69	Meningitis, Cryptococcal	14.9%
70	Bacterial Infections	14.6%
71	Infection	14.6%
72	Mycetoma	14.1%
73	Myelitis, Transverse	13.9%
74	Stiff-Person Syndrome	13.8%
75	Posterior Leukoencephalopathy Syndrome	13.7%
76	Posterior reversible encephalopathy syndrome	13.7%
77	Akinetic Mutism	13.6%
78	Anoxic Encephalopathy	13.6%
79	Arachnoiditis	13.6%
80	Basal Ganglia Diseases	13.6%
81	Brain Damage, Chronic	13.6%
82	Cerebellar Diseases	13.6%
83	Encephalitis	13.6%
84	Encephalomalacia	13.6%
85	Epilepsy	13.6%
86	Hydrocephalus	13.6%
87	Congenital Hydrocephalus	13.6%
88	Hypothalamic Diseases	13.6%
89	Aseptic Meningitis	13.6%
90	Syringomyelia	13.6%
91	Thalamic Diseases	13.6%
92	Intracranial Hypertension	13.6%
93	Aura	13.6%
94	Leukoencephalopathy	13.6%
95	Essential Tremor	13.6%
96	Neuroaxonal Dystrophies	13.6%
97	Familial Tremor	13.6%
98	Headache Disorders	13.6%
99	Intracranial Hypotension	13.6%
100	Brain Edema	13.6%
101	Brain Hypoxia	13.6%
102	Aqueductal Stenosis	13.6%
103	Pneumorrhachis	13.6%
104	Writer's Cramp	13.6%
105	Spinal Muscular Atrophy	13.5%
106	Progressive Muscular Atrophy	13.5%
107	Dandy-Walker Syndrome	13.5%
108	Striatonigral Degeneration	12.9%
109	Spinal Cord Injuries	12.9%
110	Fusariosis	12.8%
111	Marchiafava-Bignami Disease	12.8%
112	West Nile Fever	12.4%
113	Myoclonic Epilepsy	12.4%
114	Epilepsy, Temporal Lobe	12.4%
115	Epilepsy, Rolandic	12.4%
116	Benign Rolandic Epilepsy	12.4%
117	Asterixis	12.3%
118	Ballismus	12.3%
119	Pseudorabies	12.3%
120	Dementia, Vascular	12.2%
121	Dystonia Musculorum Deformans	12.2%
122	Cranial nerve diseases	12.2%
123	Demyelinating Diseases	12.2%
124	Demyelination	12.2%
125	Neuromuscular Diseases	12.2%
126	Chronobiology Disorders	12.2%
127	Basal Ganglia Cerebrovascular Disease	12%
128	Candidiasis, Vulvovaginal	11.9%
129	Toxoplasmosis, Congenital	11.8%
130	Malaria, Cerebral	11.7%
131	Subacute Combined Degeneration	11.7%
132	Neurocysticercosis	11.6%
133	Epilepsy, Post-Traumatic	11.5%
134	Amyotrophic Lateral Sclerosis	11.5%
135	Progressive supranuclear palsy	11.4%
136	MPTP Poisoning	11.3%
137	Shy-Drager Syndrome	11.1%
138	Juvenile Myoclonic Epilepsy	11.1%
139	Myoclonic Epilepsies, Progressive	11.1%
140	Vascular Headaches	11%
141	Central Nervous System Infection	10.9%
142	Hypoxia-Ischemia, Brain	10.9%
143	Huntington Disease	10.9%
144	Brain Injuries	10.8%
145	Brain Neoplasms	10.7%
146	Spinal Cord Neoplasms	10.7%
147	Chronic Fatigue Syndrome	10.7%
148	Tinea Capitis	10.7%
149	Onychomycosis	10.7%
150	Motor Neuron Disease	10.5%
151	Panophthalmitis	10.5%
152	Brain Diseases, Metabolic	10.3%
153	Cerebrovascular Disorders	10.3%
154	Cerebrovascular Insufficiency	10.3%
155	Dementia	10.3%
156	Conus Medullaris Syndrome	10.3%
157	Spinal Cord Vascular Diseases	10.3%
158	Cerebellar Neoplasms	10.3%
159	Neuroleptic Malignant Syndrome	10.2%
160	Myelinolysis, Central Pontine	10.2%
161	Borrelia Infections	10.2%
162	Leptospirosis	10.2%
163	Cerebral Palsy	10.1%
164	Epilepsies, Partial	10.1%
165	Epilepsy, Generalized	10.1%
166	Pseudotumor Cerebri	10.1%
167	Hypertensive Encephalopathy	10.1%
168	Simple Partial Seizures	10.1%
169	Epilepsy, Reflex	10.1%
170	Headache Disorders, Primary	10.1%
171	Headache Disorders, Secondary	10.1%
172	Medication overuse headache	10.1%
173	Leukomalacia, Periventricular	10%
174	Lyme Disease	9.9%
175	Relapsing Fever	9.9%
176	Skin Diseases, Bacterial	9.6%
177	Brain Death	9.5%
178	Bacteremia	9.5%
179	Waterhouse-Friderichsen Syndrome	9.5%
180	Trauma, Nervous System	9.4%
181	Pelvic Infection	9.3%
182	Wound Infection	9.3%
183	Gram-Negative Bacterial Infections	9.3%
184	Gram-Positive Bacterial Infections	9.3%
185	Soft Tissue Infection	9.3%
186	Community-Acquired Infections	9.3%
187	Leukoencephalitis, Acute Hemorrhagic	9.2%
188	Lafora Disease	9.2%
189	Unverricht-Lundborg Syndrome	9.2%
190	Ophthalmoplegic Migraine	9.2%
191	Friedreich Ataxia	9.2%
192	Tinea Pedis	9.1%
193	Nervous System Neoplasms	9.1%
194	Neurologic Manifestations	9.1%
195	Neurotoxicity Syndromes	9.1%
196	Erythema Chronicum Migrans	8.9%
197	Impetigo	8.9%
198	Central Cord Syndrome	8.8%
199	Erysipelas	8.8%
200	Staphylococcal Skin Infections	8.8%
201	Basal Ganglia Hemorrhage	8.8%
202	Akathisia, Drug-Induced	8.8%
203	Presenile dementia	8.7%
204	Senile dementia	8.7%
205	Chorea	8.7%
206	Syphilis	8.6%
207	Autonomic Dysreflexia	8.6%
208	Complex Regional Pain Syndromes	8.6%
209	Encephalomyelitis, Acute Disseminated	8.6%
210	Opsoclonus-Myoclonus Syndrome	8.6%
211	Polyradiculoneuropathy	8.6%
212	Polyradiculoneuritis	8.6%
213	Erythrasma	8.5%
214	Botulism	8.5%
215	Amblyopia	8.4%
216	Ulcerative stomatitis	8.4%
217	Post-Traumatic Headache	8.4%
218	Tension Headache	8.4%
219	Epilepsy, Complex Partial	8.4%
220	Migraine Disorders	8.4%
221	Abdominal Migraine	8.4%
222	Status Migrainosus	8.4%
223	Cervicogenic Headache	8.4%
224	Pituitary Apoplexy	8.3%
225	Restless Legs Syndrome	8.3%
226	Human Ehrlichiosis	8.3%
227	Hepatolenticular Degeneration	8.3%
228	Brain Infarction	8.2%
229	Hidradenitis Suppurativa	8.1%
230	Meningitis, Fungal	8.1%
231	Dyskinesia, Drug-Induced	8.1%
232	Bacterial Endocarditis	8%
233	Putaminal Hemorrhage	8%
234	Miller Fisher Syndrome	8%
235	Pituitary Diseases	8%
236	Brain Injuries, Diffuse	7.9%
237	Traumatic Brain Injury	7.9%
238	Pituitary Adenoma	7.9%
239	Pituitary Neoplasms	7.9%
240	Cerebellar Ataxia	7.9%
241	Supratentorial Neoplasms	7.9%
242	Torticollis	7.9%
243	Japanese Spotted Fever	7.9%
244	Brain Hemorrhage, Traumatic	7.9%
245	Infarction, Middle Cerebral Artery	7.8%
246	Infarction, Anterior Cerebral Artery	7.8%
247	Infarction, Posterior Cerebral Artery	7.8%
248	Carotid Artery Injuries	7.8%
249	Staphylococcal Scalded Skin Syndrome	7.6%
250	Ecthyma	7.6%
251	Subacute Bacterial Endocarditis	7.6%
252	Carotid Artery Diseases	7.6%
253	Brain Ischemia	7.6%
254	Cerebrovascular accident	7.6%
255	Kluver-Bucy Syndrome	7.6%
256	Vasospasm, Intracranial	7.6%
257	Spinal Cord Ischemia	7.6%
258	Intracranial Arterial Diseases	7.6%
259	Persistent Vegetative State	7.6%
260	Chlamydia Infections	7.5%
261	Gonorrhea	7.5%
262	Cluster Headache	7.5%
263	Migraine with Aura	7.5%
264	Familial Hemiplegic Migraine	7.5%
265	Chronic Paroxysmal Hemicrania	7.5%
266	SUNCT Syndrome	7.5%
267	Paroxysmal Hemicrania	7.5%
268	Pertussis	7.5%
269	Sleep Wake Disorders	7.4%
270	Cerebral Infarction	7.3%
271	Brain Stem Infarctions	7.3%
272	Endotoxemia	7.3%
273	Canavan Disease	7.3%
274	Alexander Disease	7.3%
275	Eye Infection	7.3%
276	Respiratory Tract Infections	7.3%
277	Vasculitis, Central Nervous System	7.2%
278	Paraneoplastic Cerebellar Degeneration	7.2%
279	Rocky Mountain Spotted Fever	7.2%
280	Aspergillosis, Allergic Bronchopulmonary	7.2%
281	carbuncle	7%
282	Bone Diseases, Infectious	7%
283	Pregnancy Complications, Infectious	7%
284	Skin Diseases, Infectious	7%
285	Dysautonomia	7%
286	Vagus Nerve Disorder	7%
287	Glossopharyngeal Neuralgia	7%
288	Abducens Nerve Diseases	7%
289	Heavy Metal Poisoning, Nervous System	7%
290	Neuromuscular Junction Diseases	7%
291	Tauopathies	7%
292	Trochlear Nerve Diseases	7%
293	Peripheral Nervous System Diseases	7%
294	Peripheral Nerve Injuries	6.9%
295	Human anaplasmosis	6.9%
296	Tardive Dyskinesia	6.9%
297	Arthritis, Infectious	6.9%
298	Suppuration	6.9%
299	Guillain-Barre Syndrome	6.9%
300	Lateral Medullary Syndrome	6.9%
301	Myasthenia Gravis	6.8%
302	Joint Tuberculosis	6.8%
303	Tuberculosis, Osteoarticular	6.8%
304	Bone Tuberculosis	6.8%
305	Cross Infection	6.8%
306	Septicemia	6.8%
307	Sepsis	6.8%
308	Amnesia, Transient Global	6.8%
309	Actinomycetales Infections	6.8%
310	Bordetella Infections	6.8%
311	Brucellosis	6.8%
312	Campylobacter infection	6.8%
313	Clostridium Infections	6.8%
314	Enterobacteriaceae Infections	6.8%
315	Listeriosis	6.8%
316	Pseudomonas Infections	6.8%
317	Q Fever	6.8%
318	Staphylococcal Infections	6.8%
319	Streptococcal Infections	6.8%
320	Vibrio Infections	6.8%
321	Helicobacter Infections	6.8%
322	Bacillaceae Infections	6.8%
323	Neisseriaceae Infections	6.8%
324	Burkholderia Infections	6.8%
325	Clostridium difficile infection	6.8%
326	Flavobacteriaceae Infections	6.8%
327	Moraxellaceae Infections	6.8%
328	Burkholderia cepacia Infection	6.8%
329	Bacterial Vaginosis	6.8%
330	Cellulitis	6.8%
331	Progressive bulbar palsy	6.8%
332	Bulbar palsy	6.8%
333	Causalgia	6.7%
334	Moyamoya Disease	6.7%
335	Furunculosis	6.6%
336	furuncle	6.6%
337	Diffuse Axonal Injury	6.6%
338	Brain Stem Neoplasms	6.5%
339	Lymphogranuloma Venereum	6.5%
340	Empty Sella Syndrome	6.4%
341	Hyperpituitarism	6.4%
342	Hypopituitarism	6.4%
343	Hypophysitis	6.4%
344	Cerebral Arterial Diseases	6.2%
345	Vertebrobasilar Insufficiency	6.2%
346	Anterior Spinal Artery Syndrome	6.2%
347	Basilar Artery Stenosis	6.2%
348	Vertebral Artery Stenosis	6.2%
349	Intracranial Hemorrhage, Hypertensive	6.2%
350	Transient Cerebral Ischemia	6.2%
351	Hordeolum	6.2%
352	Bacterial conjunctivitis	6.1%
353	Olfactory Nerve Injuries	6.1%
354	Reye Syndrome	6%
355	Syphilis, Congenital	6%
356	Pyomyositis	6%
357	Intracranial Embolism and Thrombosis	6%
358	Hepatic Encephalopathy	6%
359	Opportunistic Infections	6%
360	Subarachnoid Hemorrhage, Traumatic	5.9%
361	Carotid Artery, Internal, Dissection	5.9%
362	Lambert-Eaton Myasthenic Syndrome	5.9%
363	Reflex Sympathetic Dystrophy	5.9%
364	Nocturnal Myoclonus Syndrome	5.9%
365	Sleep Disorders, Circadian Rhythm	5.9%
366	Choroid Plexus Papilloma	5.9%
367	Rhinoscleroma	5.8%
368	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.8%
369	Ophthalmia Neonatorum	5.8%
370	Trachoma	5.8%
371	Frontotemporal dementia	5.7%
372	Mitochondrial Encephalomyopathies	5.7%
373	Ataxia Telangiectasia	5.6%
374	Central Nervous System Cysts	5.6%
375	Hyperprolactinemia	5.6%
376	Acinetobacter Infections	5.6%
377	Actinomycosis	5.6%
378	Bacteroides Infections	5.6%
379	Cholera	5.6%
380	Corynebacterium Infections	5.6%
381	Escherichia coli Infections	5.6%
382	Gas Gangrene	5.6%
383	Haemophilus Infections	5.6%
384	Klebsiella Infections	5.6%
385	Meningococcal Infections	5.6%
386	Mycobacterium Infections	5.6%
387	Mycoplasma Infections	5.6%
388	Nocardia Infections	5.6%
389	Pasteurella Infections	5.6%
390	Pneumococcal Infections	5.6%
391	Proteus Infections	5.6%
392	Rickettsia Infections	5.6%
393	Salmonella infections	5.6%
394	Scarlet Fever	5.6%
395	Scrub Typhus	5.6%
396	Tetanus	5.6%
397	Psoas Abscess	5.6%
398	Serratia Infections	5.6%
399	Ureaplasma Infections	5.6%
400	Abdominal Abscess	5.6%
401	Pulmonary Nocardiosis	5.6%
402	Neuromyelitis Optica	5.6%
403	Subclavian Steal Syndrome	5.6%
404	Pick Disease of the Brain	5.6%
405	Urinary tract infection	5.6%
406	Pneumonia, Bacterial	5.5%
407	Brain Contusion	5.5%
408	Myopathy	5.5%
409	Optic Neuropathy	5.5%
410	Vertebral Artery Dissection	5.4%
411	Multiple Sclerosis	5.4%
412	Erysipelothrix infection	5.4%
413	Brain Concussion	5.3%
414	Facial Nerve Diseases	5.3%
415	Craniocerebral Trauma	5.3%
416	Parasomnia	5.3%
417	Dyssomnias	5.3%
418	Facial Nerve Injuries	5.2%
419	Alice in Wonderland Syndrome	5.2%
420	Vestibulocochlear Nerve Diseases	5.2%
421	Decerebrate State	5.2%
422	Endophthalmitis	5.2%
423	Hemiparesis	5.2%
424	Hydranencephaly	5.2%
425	Meningism	5.2%
426	Neural Tube Defects	5.2%
427	Paresis	5.2%
428	Peritonitis	5.2%
429	Seizures	5.2%
430	Sensation Disorders	5.2%
431	Tethered Cord Syndrome	5.2%
432	Central Nervous System Neoplasms	5.2%
433	Complex partial seizures	5.2%
434	Iniencephaly	5.2%
435	Craniorachischisis	5.2%
436	Exencephaly	5.2%
437	Monoparesis	5.2%
438	Septo-Optic Dysplasia	5.2%
439	Cortical Dysplasia	5.2%
440	Neurogenic Inflammation	5.2%
441	Gait Disorders, Neurologic	5.2%
442	Neuromuscular Manifestations	5.2%
443	Malformations of Cortical Development	5.2%
444	MELAS Syndrome	5.2%
445	Sweating, Gustatory	5.1%
446	Auriculotemporal Syndrome	5.1%
447	Osteomyelitis	5.1%
448	Periostitis	5.1%
449	Surgical Wound Infection	5.1%
450	Adrenoleukodystrophy	5.1%
451	Abscess	5%
452	Adnexitis	5%
453	Empyema	5%
454	Horner Syndrome	5%
455	Pelvic Inflammatory Disease	5%
456	Diphtheria	5%
457	Leprosy	5%
458	Mycobacterium Infections, Nontuberculous	5%
459	Psittacosis	5%
460	Paratyphoid Fever	5%
461	Plague	5%
462	Tuberculosis	5%
463	Typhoid Fever	5%
464	TYPHUS	5%
465	Yersinia pseudotuberculosis Infections	5%
466	Bubonic Plague	5%
467	Brain Diseases, Metabolic, Inborn	5%
468	Mycobacterium abscessus Infection	5%
469	Brachial Plexus Neuritis	5%
470	Neuralgic Amyotrophy	5%
471	Tuberculosis, Spinal	5%
472	Carotid Stenosis	5%
473	Intracranial Aneurysm	5%
474	Erythema Induratum	5%
475	Intracranial Arteriosclerosis	5%
476	Cerebral Atherosclerosis	5%
477	Subarachnoid Hemorrhage	5%
478	Cerebral Arteriosclerosis	5%
479	Cerebral Hemorrhage	5%
480	Auditory Perceptual Disorders	4.9%
481	Cerebral Thrombosis	4.9%
482	Intracranial Embolism	4.9%
483	Intracranial Thrombosis	4.9%
484	Sexually Transmitted Diseases	4.8%
485	Mycobacterium avium-intracellulare Infection	4.7%
486	Lymph Node Tuberculosis	4.7%
487	Tuberculosis, Miliary	4.7%
488	Tuberculosis, Multidrug-Resistant	4.7%
489	Leprosy, Multibacillary	4.7%
490	Latent Tuberculosis	4.7%
491	Acrodynia	4.7%
492	Borderline leprosy	4.6%
493	Leprosy, Lepromatous	4.6%
494	Tuberculoid leprosy	4.6%
495	Extensively Drug-Resistant Tuberculosis	4.6%
496	Tarsal Tunnel Syndrome	4.6%
497	Cauda Equina Syndrome	4.6%
498	Neuritis	4.5%
499	Polyneuritis	4.5%
500	Radiculitis	4.5%
501	Polyneuropathy	4.5%
502	Mononeuritis	4.5%
503	Mononeuropathies	4.5%
504	Brachial Plexus Neuropathies	4.5%
505	Radiculopathy	4.5%
506	Mononeuropathy Multiplex	4.5%
507	Nerve Root Compression	4.5%
508	Myasthenia Gravis, Autoimmune, Experimental	4.5%
509	Ophthalmoplegia	4.5%
510	External Ophthalmoplegia	4.5%
511	Acromegaly	4.5%
512	Charcot-Marie-Tooth Disease	4.5%
513	Cerebral Amyloid Angiopathy	4.4%
514	Sinus Thrombosis, Intracranial	4.4%
515	Jet Lag Syndrome	4.3%
516	Pupil Disorders	4.3%
517	Neurobehavioral Manifestations	4.3%
518	Wernicke Encephalopathy	4.3%
519	Refsum Disease	4.3%
520	AIDS Dementia Complex	4.3%
521	Giant Cell Arteritis	4.2%
522	Temporal Arteritis	4.2%
523	Coma, Post-Head Injury	4.2%
524	Diverticulitis	4.2%
525	Superinfection	4.2%
526	Paraneoplastic Encephalomyelitis	4.2%
527	Cavernous Sinus Thrombosis	4.2%
528	Sagittal Sinus Thrombosis	4.2%
529	Corneal Ulcer	4.1%
530	Uveomeningoencephalitic Syndrome	4.1%
531	Carotid Artery Thrombosis	4.1%
532	Sturge-Weber Syndrome	4.1%
533	Vertigo	4.1%
534	Alcohol-Induced Disorders, Nervous System	4.1%
535	Puerperal Infection	4.1%
536	Spondylitis	4.1%
537	Tuberous Sclerosis	4%
538	Appendicitis	4%
539	Bacteriuria	4%
540	Pyuria	4%
541	Endotoxic shock	4%
542	Septic Shock	4%
543	Toxic Shock Syndrome	4%
544	Hematoma, Subdural	4%
545	Hematoma, Epidural, Cranial	4%
546	Salmonella Infections, Animal	4%
547	Multiple Sclerosis, Chronic Progressive	4%
548	Multiple Sclerosis, Relapsing-Remitting	4%
549	Myotonia Congenita	3.9%
550	Vocal Cord Paralysis	3.9%
551	Cerebrospinal Fluid Otorrhea	3.9%
552	Cerebrospinal Fluid Rhinorrhea	3.9%
553	Neuritis, Autoimmune, Experimental	3.9%
554	Gait Ataxia	3.9%
555	Liver Abscess	3.8%
556	Rheumatic Heart Disease	3.8%
557	Kernicterus	3.8%
558	Salmonella food poisoning	3.8%
559	Carpal Tunnel Syndrome	3.7%
560	neurofibroma	3.6%
561	Sciatica	3.6%
562	Tuberculosis, Gastrointestinal	3.6%
563	Hematoma, Subdural, Intracranial	3.6%
564	Hematoma, Subdural, Chronic	3.6%
565	Hematoma, Subdural, Acute	3.6%
566	Myotonic Dystrophy	3.5%
567	Voice Disorders	3.5%
568	Voice Disturbance	3.5%
569	Nelson Syndrome	3.5%
570	Lung Abscess	3.4%
571	Myositis	3.4%
572	Optic Atrophy	3.4%
573	Optic Neuritis	3.4%
574	Papilledema	3.4%
575	Strabismus	3.4%
576	Tolosa-Hunt Syndrome	3.4%
577	Isaacs syndrome	3.4%
578	Arsenic Poisoning	3.4%
579	Myotonic Disorders	3.4%
580	Myasthenic Syndromes, Congenital	3.4%
581	Smith-Magenis syndrome	3.4%
582	Rheumatic Fever	3.4%
583	Diabetic Neuropathies	3.4%
584	Facial Injuries	3.4%
585	Facial Neuralgia	3.4%
586	Diabetic Amyotrophy	3.4%
587	Diabetic Autonomic Neuropathy	3.4%
588	Sleep Talking	3.4%
589	Manganese Poisoning	3.4%
590	Dural Arteriovenous Fistula	3.4%
591	Sleep Disorders, Intrinsic	3.4%
592	Orthostatic intolerance	3.4%
593	Diverticulum	3.4%
594	Diverticulosis	3.4%
595	Sciatic Neuropathy	3.4%
596	Ulnar Neuropathies	3.4%
597	Lesion of Sciatic Nerve	3.4%
598	Ulnar Neuritis	3.4%
599	Radial nerve compression	3.4%
600	Radial Tunnel Syndrome	3.4%
601	Peroneal Neuropathies	3.4%
602	Radial Neuropathy	3.4%
603	Median Neuropathy	3.4%
604	Sciatic Nerve Palsy	3.4%
605	Femoral Neuropathy	3.4%
606	Tibial Neuropathy	3.4%
607	Ulnar Nerve Palsy	3.4%
608	Postural Orthostatic Tachycardia Syndrome	3.4%
609	Radial nerve palsy	3.4%
610	Anosmia	3.4%
611	Ataxia	3.4%
612	Athetosis	3.4%
613	Catalepsy	3.4%
614	Dystonia	3.4%
615	Hemiplegia	3.4%
616	Locked-In Syndrome	3.4%
617	Meningeal Neoplasms	3.4%
618	Meningomyelocele	3.4%
619	Muscle Hypertonia	3.4%
620	Muscle hypotonia	3.4%
621	Myoclonus	3.4%
622	Myotonia	3.4%
623	Neuralgia	3.4%
624	Paraplegia	3.4%
625	Pseudobulbar Palsy	3.4%
626	Quadriplegia	3.4%
627	Spasm	3.4%
628	Spastic Paraplegia	3.4%
629	Status Epilepticus	3.4%
630	Taste Disorders	3.4%
631	Tremor	3.4%
632	Spina Bifida	3.4%
633	Monoplegia	3.4%
634	Hypokinesia	3.4%
635	Paraparesis	3.4%
636	Bradykinesia	3.4%
637	Waxy flexibility	3.4%
638	Action Tremor	3.4%
639	Resting Tremor	3.4%
640	Dysosmia	3.4%
641	Quadriparesis	3.4%
642	Mercury Poisoning, Nervous System	3.4%
643	Olfaction Disorders	3.4%
644	Myokymia	3.4%
645	Lead Poisoning, Nervous System	3.4%
646	Vestibular Neuronitis	3.4%
647	Somatosensory Disorders	3.4%
648	Neuropathic pain	3.4%
649	Hyperkinesia	3.4%
650	Intention tremor	3.4%
651	Alcohol Withdrawal Seizures	3.3%
652	Discitis	3.3%
653	Enterocolitis, Pseudomembranous	3.3%
654	Mastoiditis	3.3%
655	Petrositis	3.3%
656	pseudomembranous colitis	3.3%
657	Dysentery, Bacillary	3.3%
658	Akathisia	3.3%
659	Restlessness	3.3%
660	Psychomotor Agitation	3.3%
661	Arthritis, Reactive	3.3%
662	Cubital Tunnel Syndrome	3.3%
663	Prolactinoma	3.2%
664	Growth Hormone-Secreting Pituitary Adenoma	3.2%
665	Fabry Disease	3.2%
666	Optic Nerve Glioma	3.1%
667	Galactosemias	3.1%
668	Urea Cycle Disorders, Inborn	3.1%
669	Tyrosinemias	3.1%
670	Gait Apraxia	3%
671	AIDS-Related Opportunistic Infections	2.9%
672	Tuberculosis, Pulmonary	2.9%
673	Reflex, Abnormal	2.9%
674	Hyporeflexia	2.9%
675	Hyperreflexia	2.9%
676	Hand-Arm Vibration Syndrome	2.9%
677	Alstrom Syndrome	2.8%
678	Vision Disorders	2.8%
679	Metamorphopsia	2.8%
680	Visual Impairment	2.8%
681	Polyradiculopathy	2.8%
682	Retropharyngeal Abscess	2.8%
683	Fibromyalgia	2.8%
684	Optic Neuropathy, Ischemic	2.8%
685	Anterior Ischemic Optic Neuropathy	2.8%
686	Medial Tibial Stress Syndrome	2.8%
687	Peritonsillar Abscess	2.7%
688	Homocystinuria	2.7%
689	Facial Hemiatrophy	2.7%
690	Melkersson-Rosenthal Syndrome	2.7%
691	Mitochondrial Myopathies	2.7%
692	Leigh Disease	2.7%
693	Anisocoria	2.7%
694	Confusion	2.7%
695	Facial paralysis	2.7%
696	Lethargy	2.7%
697	Memory Disorders	2.7%
698	Muscle Cramp	2.7%
699	Perceptual Disorders	2.7%
700	Psychomotor Disorders	2.7%
701	Tonic Pupil	2.7%
702	Eosinophilia-Myalgia Syndrome	2.7%
703	Anhedonia	2.7%
704	Disorientation	2.7%
705	Facial Paresis	2.7%
706	Memory Loss	2.7%
707	Hemisensory Neglect	2.7%
708	Dysacusis	2.7%
709	Menkes Kinky Hair Syndrome	2.7%
710	Sleep Bruxism	2.7%
711	Anencephaly	2.7%
712	Meningocele	2.7%
713	Muscular Atrophy	2.7%
714	Respiratory Paralysis	2.7%
715	Encephalocele	2.7%
716	Tetany	2.7%
717	Thoracic Outlet Syndrome	2.6%
718	Classical Lissencephalies and Subcortical Band Heterotopias	2.6%
719	Amyloid Neuropathies, Familial	2.6%
720	Esotropia	2.5%
721	Exotropia	2.5%
722	Hypotension, Orthostatic	2.5%
723	Sleep Apnea Syndromes	2.5%
724	Polymyositis	2.5%
725	Post-Exercise Hypotension	2.5%
726	Disorders of Excessive Somnolence	2.5%
727	Sleep Initiation and Maintenance Disorders	2.5%
728	Night Terrors	2.5%
729	Somnambulism	2.5%
730	Trigeminal Nerve Disorder	2.5%
731	Transient Insomnia	2.5%
732	Sleep Paralysis	2.5%
733	Chronic Insomnia	2.5%
734	REM Sleep Behavior Disorder	2.5%
735	Hypersomnia	2.5%
736	Dermal Sinus	2.5%
737	Dysgeusia	2.5%
738	Formication	2.5%
739	Hyperalgesia	2.5%
740	Hyperesthesia	2.5%
741	Hypesthesia	2.5%
742	Language Disorders	2.5%
743	Numbness	2.5%
744	Paresthesia	2.5%
745	Paraparesis, Spastic	2.5%
746	Spina Bifida Cystica	2.5%
747	Trismus	2.5%
748	Spina Bifida Occulta	2.5%
749	Epilepsia Partialis Continua	2.5%
750	Hypogeusia	2.5%
751	Meningeal Carcinomatosis	2.5%
752	Brown-Sequard Syndrome	2.5%
753	Lissencephaly	2.5%
754	Polymicrogyria	2.5%
755	Pachygyria	2.5%
756	Schizencephaly	2.5%
757	Lockjaw	2.5%
758	Allodynia	2.5%
759	Lead Poisoning, Nervous System, Childhood	2.5%
760	Lead Poisoning, Nervous System, Adult	2.5%
761	Periventricular Nodular Heterotopia	2.5%
762	Ageusia	2.5%
763	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.4%
764	Acoustic Neuroma	2.4%
765	Alexia	2.3%
766	Dyslexia	2.3%
767	Duane Retraction Syndrome	2.3%
768	Consciousness Disorders	2.3%
769	Mental Retardation	2.3%
770	Muscle Weakness	2.3%
771	Depressed Level of Consciousness	2.3%
772	Mental deficiency	2.3%
773	Intellectual Disability	2.3%
774	Mobius Syndrome	2.3%
775	Bell Palsy	2.3%
776	Catatonia	2.3%
777	Herpes Zoster Oticus	2.3%
778	Familial Periodic Paralysis	2.2%
779	Aphonia	2.2%
780	Sleep Deprivation	2.2%
781	Dysphonia	2.2%
782	Neurofibrosarcoma	2.2%
783	Glycogen storage disease type II	2.2%
784	Eye Injuries	2.1%
785	Sleep Apnea, Obstructive	2.1%
786	Sleep Apnea, Central	2.1%
787	Narcolepsy	2.1%
788	Trigeminal Neuralgia	2.1%
789	Kleine-Levin Syndrome	2.1%
790	Zellweger Syndrome	2.1%
791	Agraphia	2.1%
792	Anomia	2.1%
793	Cluttering	2.1%
794	Language Development Disorders	2.1%
795	Speech Disorders	2.1%
796	Syncope	2.1%
797	Stupor	2.1%
798	Dysgraphia	2.1%
799	Presyncope	2.1%
800	Dyslalia	2.1%
801	Liver Abscess, Amebic	2%
802	Muscular Dystrophy	2%
803	Congenital nystagmus	2%
804	Orbital Myositis	2%
805	Kearns-Sayre syndrome	2%
806	Diplopia	2%
807	Muscle Rigidity	2%
808	Muscle Spasticity	2%
809	Scotoma	2%
810	Photophobia	2%
811	Cogwheel Rigidity	2%
812	Hemifacial Spasm	2%
813	Amaurosis	2%
814	Blindness	2%
815	Nuchal Rigidity	2%
816	Optic Atrophy, Hereditary, Leber	2%
817	Agnosia	2%
818	Apraxias	2%
819	Hallucinations	2%
820	Hemianopsia	2%
821	Hyperacusis	2%
822	Tinnitus	2%
823	Visual Agnosia	2%
824	Anosognosia	2%
825	Wernicke-Korsakoff Syndrome	2%
826	Phonophobia	2%
827	Hearing Loss	2%
828	Sarcopenia	2%
829	Tuberculosis, Renal	2%
830	Myalgia	1.9%
831	Neuronal Ceroid-Lipofuscinoses	1.9%
832	Lemierre Syndrome	1.9%
833	Gaucher Disease	1.9%
834	Cataplexy	1.9%
835	Aphasia	1.8%
836	Articulation Disorders	1.8%
837	Echolalia	1.8%
838	Stuttering	1.8%
839	Dysphasia	1.8%
840	Tay-Sachs Disease	1.8%
841	Dysarthria	1.7%
842	Aicardi's syndrome	1.7%
843	Hoarseness	1.7%
844	Amnesia	1.7%
845	Delirium	1.7%
846	Dissociative Amnesia	1.7%
847	Color blindness	1.7%
848	Global Amnesia	1.7%
849	Eye Burns	1.7%
850	Cri-du-Chat Syndrome	1.7%
851	Down Syndrome	1.7%
852	Trisomy 21	1.7%
853	Cockayne Syndrome	1.7%
854	POEMS Syndrome	1.7%
855	Alcohol Withdrawal Delirium	1.7%
856	Meningioma	1.7%
857	Williams Syndrome	1.7%
858	Welander Distal Myopathy	1.7%
859	Microcephaly	1.7%
860	Amaurosis Fugax	1.7%
861	Blindness, Cortical	1.7%
862	Macrocephaly	1.7%
863	Dyscalculia	1.7%
864	Rett Syndrome	1.7%
865	Hypokalemic periodic paralysis	1.6%
866	Niemann-Pick Disease, Type C	1.6%
867	Deafness	1.6%
868	Hearing Loss, Sudden	1.6%
869	Gerstmann Syndrome	1.6%
870	Hearing Loss, Bilateral	1.6%
871	Hearing Loss, High-Frequency	1.6%
872	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
873	Prosopagnosia	1.6%
874	Apraxia, Ideomotor	1.6%
875	Charles Bonnet Syndrome	1.6%
876	Hearing Loss, Unilateral	1.6%
877	Complete Hearing Loss	1.6%
878	Alien Hand Syndrome	1.6%
879	Deaf Mutism	1.6%
880	Porencephaly	1.6%
881	Mutism	1.5%
882	Selective Mutism	1.5%
883	Holoprosencephaly	1.5%
884	Prader-Willi Syndrome	1.4%
885	Dermatomyositis	1.4%
886	Corneal Scar	1.4%
887	Phantom pain	1.4%
888	Phantom Limb Pain	1.4%
889	Alexia, Pure	1.4%
890	Muscular Dystrophy, Duchenne	1.4%
891	Retrograde amnesia	1.4%
892	Amnesia, Anterograde	1.4%
893	Corneal Perforation	1.2%
894	Fragile X Syndrome	1.2%
895	Rubinstein-Taybi Syndrome	1.1%
896	Mucopolysaccharidosis II	0.8%

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