MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

MPTP Poisoning

(UMLS:C0270730)

Definition:: A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
UMLS ID:: C0270730
MeSH ID:: D020267

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.079.862.800.300|C10.228.662.600.700.250|C10.720.606

Classification 2:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.723.705.400

Synonym(s)

MPTP Poisoning

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism

MPTP - Methylphenyltetrahydropyridine-induced parkinsonism

MPTP-induced parkinsonism

Methylphenyltetrahydropyridine-induced parkinsonism

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	View details 9503263 19594327 20230807 21092260 23062100	CTD
2	1-Methyl-4-phenylpyridinium	26364587	CTD
3	Caffeine	20230807	CTD
4	Ditiocarb	9503263	CTD
5	Nicotine	9503263 19594327 20230807	CTD
6	nitroflurbiprofen	21092260	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Neuroleptic Malignant Syndrome	42.3%
2	Parkinson Disease	37.2%
3	Akathisia, Drug-Induced	36.1%
4	Multiple System Atrophy	35.8%
5	Lewy Body Disease	35.6%
6	Dyskinesia, Drug-Induced	32.3%
7	Encephalomyelitis	30.4%
8	Alcohol-Induced Disorders, Nervous System	30.3%
9	Meningoencephalitis	29.6%
10	Meige Syndrome	25.9%
11	Ocular Motility Disorders	25.3%
12	Cyclophoria	25.3%
13	Progressive supranuclear palsy	25.2%
14	Pneumocephalus	24.9%
15	Dystonia Musculorum Deformans	23.9%
16	Subdural Effusion	23.3%
17	Botulism	23.1%
18	Striatonigral Degeneration	23.1%
19	Meningitis	22.9%
20	Pachymeningitis	22.9%
21	Spinal Cord Diseases	22.9%
22	Arsenic Poisoning	22.7%
23	Stiff-Person Syndrome	22.7%
24	Asterixis	22.5%
25	Ballismus	22.5%
26	Myelitis	22.3%
27	Epidural Abscess	22.1%
28	Dandy-Walker Syndrome	22.1%
29	Heavy Metal Poisoning, Nervous System	21.9%
30	Basal Ganglia Cerebrovascular Disease	21.8%
31	Huntington Disease	21.2%
32	Prion Diseases	20.6%
33	Brain Abscess	20.6%
34	Shy-Drager Syndrome	20.6%
35	Alcohol Withdrawal Seizures	20%
36	Essential Tremor	20%
37	Familial Tremor	20%
38	Writer's Cramp	20%
39	Subacute Combined Degeneration	20%
40	Cranial nerve diseases	19.8%
41	Demyelinating Diseases	19.8%
42	Demyelination	19.8%
43	Neuromuscular Diseases	19.8%
44	Chronobiology Disorders	19.8%
45	Central Nervous System Infection	19.8%
46	Spinal Muscular Atrophy	19.8%
47	Progressive Muscular Atrophy	19.8%
48	Marchiafava-Bignami Disease	19.4%
49	Akinetic Mutism	19.3%
50	Anoxic Encephalopathy	19.3%
51	Brain Damage, Chronic	19.3%
52	Cerebellar Diseases	19.3%
53	Encephalitis	19.3%
54	Encephalomalacia	19.3%
55	Epilepsy	19.3%
56	Hydrocephalus	19.3%
57	Congenital Hydrocephalus	19.3%
58	Hypothalamic Diseases	19.3%
59	Thalamic Diseases	19.3%
60	Intracranial Hypertension	19.3%
61	Aura	19.3%
62	Leukoencephalopathy	19.3%
63	Neuroaxonal Dystrophies	19.3%
64	Headache Disorders	19.3%
65	Intracranial Hypotension	19.3%
66	Brain Edema	19.3%
67	Brain Hypoxia	19.3%
68	Aqueductal Stenosis	19.3%
69	Amyotrophic Lateral Sclerosis	19.3%
70	Manganese Poisoning	19.2%
71	Dementia, Vascular	19.1%
72	Brain Injuries	18.9%
73	Motor Neuron Disease	18.9%
74	Brain Neoplasms	18.8%
75	Spinal Cord Injuries	18.2%
76	Epilepsy, Post-Traumatic	18%
77	Hepatolenticular Degeneration	18%
78	Poliomyelitis	17.9%
79	Ophthalmoplegic Migraine	17.7%
80	Restless Legs Syndrome	17.7%
81	Mercury Poisoning, Nervous System	17.4%
82	Lead Poisoning, Nervous System	17.4%
83	Polyradiculoneuropathy	17.3%
84	Polyradiculoneuritis	17.3%
85	Cerebral Ventriculitis	17.2%
86	Trauma, Nervous System	17%
87	Posterior Leukoencephalopathy Syndrome	16.9%
88	Posterior reversible encephalopathy syndrome	16.9%
89	Acrodynia	16.8%
90	Myelinolysis, Central Pontine	16.6%
91	Nervous System Neoplasms	16.6%
92	Neurologic Manifestations	16.6%
93	Alcohol Withdrawal Delirium	16.5%
94	Leukoencephalopathy, Progressive Multifocal	16.5%
95	Brain Diseases, Metabolic	16.3%
96	Cerebrovascular Disorders	16.3%
97	Cerebrovascular Insufficiency	16.3%
98	Dementia	16.3%
99	Brain Death	16.3%
100	Leukoencephalitis, Acute Hemorrhagic	16.2%
101	Myelitis, Transverse	16.1%
102	Chronic Fatigue Syndrome	16%
103	Meningitis, Bacterial	15.8%
104	Meningitis, Fungal	15.8%
105	Miller Fisher Syndrome	15.8%
106	Lupus Vasculitis, Central Nervous System	15.7%
107	Limbic Encephalitis	15.4%
108	Autonomic Dysreflexia	15.3%
109	Complex Regional Pain Syndromes	15.3%
110	Amblyopia	15.3%
111	Cerebellar Neoplasms	15.1%
112	Leukomalacia, Periventricular	15%
113	Opsoclonus-Myoclonus Syndrome	14.9%
114	Creutzfeldt-Jakob disease	14.8%
115	Spinal Cord Neoplasms	14.6%
116	Vascular Headaches	14.5%
117	Hypoxia-Ischemia, Brain	14.4%
118	Sleep Wake Disorders	14.4%
119	Brain Diseases	14.4%
120	Chorea	14.1%
121	Guillain-Barre Syndrome	14.1%
122	Encephalomyelitis, Acute Disseminated	14.1%
123	Movement Disorders	13.9%
124	Myoclonic Epilepsy	13.8%
125	Epilepsy, Temporal Lobe	13.8%
126	Epilepsy, Rolandic	13.8%
127	Benign Rolandic Epilepsy	13.8%
128	Lead Poisoning, Nervous System, Childhood	13.7%
129	Lead Poisoning, Nervous System, Adult	13.7%
130	Presenile dementia	13.7%
131	Senile dementia	13.7%
132	Arachnoiditis	13.4%
133	Aseptic Meningitis	13.4%
134	Syringomyelia	13.4%
135	Pneumorrhachis	13.4%
136	Basal Ganglia Hemorrhage	13.4%
137	Peripheral Nerve Injuries	13.3%
138	Mushroom Poisoning	13.2%
139	Myasthenia Gravis	13.1%
140	Vasculitis, Central Nervous System	13%
141	Brain Hemorrhage, Traumatic	12.9%
142	Amnesia, Transient Global	12.9%
143	Lambert-Eaton Myasthenic Syndrome	12.7%
144	Torticollis	12.6%
145	Causalgia	12.3%
146	Friedreich Ataxia	12.2%
147	Toxoplasmosis, Cerebral	12.2%
148	Parkinsonian Disorders	12.2%
149	Neuromyelitis Optica	12.2%
150	Brain Injuries, Diffuse	12.1%
151	Traumatic Brain Injury	12.1%
152	Cerebellar Ataxia	12.1%
153	Supratentorial Neoplasms	12.1%
154	Fluoride Poisoning	12.1%
155	Food Poisoning	12.1%
156	Gas Poisoning	12.1%
157	Mycotoxicosis	12.1%
158	Plant Poisoning	12.1%
159	Organophosphate poisoning	12.1%
160	Olfactory Nerve Injuries	12%
161	Canavan Disease	12%
162	Alexander Disease	12%
163	Cerebral Palsy	12%
164	Epilepsies, Partial	12%
165	Epilepsy, Generalized	12%
166	Pseudotumor Cerebri	12%
167	Hypertensive Encephalopathy	12%
168	Simple Partial Seizures	12%
169	Epilepsy, Reflex	12%
170	Headache Disorders, Primary	12%
171	Headache Disorders, Secondary	12%
172	Medication overuse headache	12%
173	Paraneoplastic Cerebellar Degeneration	11.9%
174	Progressive bulbar palsy	11.9%
175	Bulbar palsy	11.9%
176	Carotid Artery Injuries	11.8%
177	Sleep Disorders, Circadian Rhythm	11.8%
178	Tuberculosis, Meningeal	11.8%
179	Chemical and Drug Induced Liver Injury	11.7%
180	Central Nervous System Cysts	11.4%
181	Lafora Disease	11.4%
182	Unverricht-Lundborg Syndrome	11.4%
183	Scrapie	11.4%
184	Central Cord Syndrome	11.4%
185	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	11.4%
186	Persistent Vegetative State	11.4%
187	Central Nervous System Fungal Infections	11.3%
188	Conus Medullaris Syndrome	11.3%
189	Spinal Cord Vascular Diseases	11.3%
190	Dysautonomia	11.2%
191	Vagus Nerve Disorder	11.2%
192	Glossopharyngeal Neuralgia	11.2%
193	Abducens Nerve Diseases	11.2%
194	Neuromuscular Junction Diseases	11.2%
195	Tauopathies	11.2%
196	Trochlear Nerve Diseases	11.2%
197	Peripheral Nervous System Diseases	11.2%
198	Pituitary Adenoma	11.2%
199	Pituitary Neoplasms	11.2%
200	Juvenile Myoclonic Epilepsy	10.8%
201	Myoclonic Epilepsies, Progressive	10.8%
202	Facial Nerve Injuries	10.7%
203	Pituitary Apoplexy	10.5%
204	Putaminal Hemorrhage	10.5%
205	Bites and Stings	10.4%
206	Brain Infarction	10.4%
207	Pituitary Diseases	10.4%
208	Psychoses, Substance-Induced	10.2%
209	Reflex Sympathetic Dystrophy	10.2%
210	Nocturnal Myoclonus Syndrome	10.2%
211	Horner Syndrome	10.1%
212	Multiple Sclerosis	10.1%
213	Water Intoxication	10%
214	Carotid Artery Diseases	10%
215	Brain Ischemia	10%
216	Cerebrovascular accident	10%
217	Kluver-Bucy Syndrome	10%
218	Vasospasm, Intracranial	10%
219	Intracranial Arterial Diseases	10%
220	Tardive Dyskinesia	10%
221	Ataxia Telangiectasia	9.8%
222	Central Nervous System Bacterial Infections	9.8%
223	Myopathy	9.7%
224	Neurotoxicity Syndromes	9.7%
225	Optic Neuropathy	9.7%
226	Myasthenia Gravis, Autoimmune, Experimental	9.6%
227	Mitochondrial Encephalomyopathies	9.5%
228	Facial Nerve Diseases	9.4%
229	Craniocerebral Trauma	9.4%
230	Parasomnia	9.4%
231	Dyssomnias	9.4%
232	Meningitis, Cryptococcal	9.4%
233	Meningitis, Listeria	9.4%
234	Vestibulocochlear Nerve Diseases	9.3%
235	Decerebrate State	9.3%
236	Hemiparesis	9.3%
237	Hydranencephaly	9.3%
238	Meningism	9.3%
239	Neural Tube Defects	9.3%
240	Paresis	9.3%
241	Seizures	9.3%
242	Sensation Disorders	9.3%
243	Tethered Cord Syndrome	9.3%
244	Central Nervous System Neoplasms	9.3%
245	Complex partial seizures	9.3%
246	Iniencephaly	9.3%
247	Craniorachischisis	9.3%
248	Exencephaly	9.3%
249	Monoparesis	9.3%
250	Septo-Optic Dysplasia	9.3%
251	Cortical Dysplasia	9.3%
252	Neurogenic Inflammation	9.3%
253	Gait Disorders, Neurologic	9.3%
254	Neuromuscular Manifestations	9.3%
255	Malformations of Cortical Development	9.3%
256	Meningitis, Haemophilus	9.3%
257	Meningitis, Pneumococcal	9.3%
258	Sweating, Gustatory	9.3%
259	Auriculotemporal Syndrome	9.3%
260	Tuberous Sclerosis	9.1%
261	MPTP Poisoning	9.1%
262	Jet Lag Syndrome	9%
263	Charcot-Marie-Tooth Disease	9%
264	Ophthalmoplegia	8.9%
265	External Ophthalmoplegia	8.9%
266	Basal Ganglia Diseases	8.9%
267	Subacute Sclerosing Panencephalitis	8.8%
268	Diffuse Axonal Injury	8.8%
269	Brain Stem Neoplasms	8.8%
270	Infarction, Middle Cerebral Artery	8.7%
271	Infarction, Anterior Cerebral Artery	8.7%
272	Infarction, Posterior Cerebral Artery	8.7%
273	Brain Concussion	8.7%
274	Reye Syndrome	8.6%
275	Intracranial Embolism and Thrombosis	8.6%
276	Hepatic Encephalopathy	8.6%
277	Vertebral Artery Dissection	8.6%
278	Auditory Perceptual Disorders	8.5%
279	Adrenoleukodystrophy	8.5%
280	Brachial Plexus Neuritis	8.5%
281	Neuralgic Amyotrophy	8.5%
282	Post-Traumatic Headache	8.3%
283	Tension Headache	8.3%
284	Epilepsy, Complex Partial	8.3%
285	Migraine Disorders	8.3%
286	Abdominal Migraine	8.3%
287	Status Migrainosus	8.3%
288	Cervicogenic Headache	8.3%
289	Frontotemporal dementia	8.3%
290	Alice in Wonderland Syndrome	8.3%
291	Pupil Disorders	8.2%
292	Neurobehavioral Manifestations	8.2%
293	Moyamoya Disease	8.2%
294	Subarachnoid Hemorrhage, Traumatic	8.1%
295	Carotid Artery, Internal, Dissection	8.1%
296	Wernicke Encephalopathy	8.1%
297	Refsum Disease	8.1%
298	Paraneoplastic Encephalomyelitis	8.1%
299	Cerebral Infarction	8.1%
300	Brain Stem Infarctions	8.1%
301	Vocal Cord Paralysis	8%
302	Uveomeningoencephalitic Syndrome	8%
303	Sturge-Weber Syndrome	8%
304	Vertigo	8%
305	Cadmium poisoning	7.9%
306	Carbon Monoxide Poisoning	7.9%
307	Ciguatera Poisoning	7.9%
308	Ergotism	7.9%
309	Lead Poisoning	7.9%
310	Mercury Poisoning	7.9%
311	Shellfish Poisoning	7.9%
312	MELAS Syndrome	7.9%
313	Brain Contusion	7.7%
314	Myotonia Congenita	7.6%
315	Coma, Post-Head Injury	7.6%
316	Tarsal Tunnel Syndrome	7.6%
317	Cauda Equina Syndrome	7.6%
318	Cerebrospinal Fluid Otorrhea	7.6%
319	Cerebrospinal Fluid Rhinorrhea	7.6%
320	Neuritis, Autoimmune, Experimental	7.6%
321	Chemical and Drug Induced Liver Injury, Chronic	7.6%
322	Gait Ataxia	7.6%
323	Brain Diseases, Metabolic, Inborn	7.5%
324	Myotonic Dystrophy	7.4%
325	Spinal Cord Ischemia	7.3%
326	Multiple Sclerosis, Chronic Progressive	7.2%
327	Multiple Sclerosis, Relapsing-Remitting	7.2%
328	Tuberculosis, Central Nervous System	7.2%
329	Choroid Plexus Papilloma	7.2%
330	Voice Disorders	7.1%
331	Voice Disturbance	7.1%
332	Neuritis	7.1%
333	Polyneuritis	7.1%
334	Radiculitis	7.1%
335	Polyneuropathy	7.1%
336	Mononeuritis	7.1%
337	Mononeuropathies	7.1%
338	Brachial Plexus Neuropathies	7.1%
339	Radiculopathy	7.1%
340	Mononeuropathy Multiplex	7.1%
341	Nerve Root Compression	7.1%
342	Empty Sella Syndrome	7.1%
343	Hyperpituitarism	7.1%
344	Hypopituitarism	7.1%
345	Hypophysitis	7.1%
346	Smith-Magenis syndrome	7%
347	Giant Cell Arteritis	7%
348	Temporal Arteritis	7%
349	Dural Arteriovenous Fistula	7%
350	Lateral Medullary Syndrome	6.9%
351	Cerebral Arterial Diseases	6.9%
352	Vertebrobasilar Insufficiency	6.9%
353	Basilar Artery Stenosis	6.9%
354	Vertebral Artery Stenosis	6.9%
355	Intracranial Hemorrhage, Hypertensive	6.9%
356	Transient Cerebral Ischemia	6.9%
357	Drug toxicity	6.9%
358	Optic Nerve Glioma	6.8%
359	Akathisia	6.7%
360	Restlessness	6.7%
361	Psychomotor Agitation	6.7%
362	Insect Bites and Stings	6.7%
363	West Nile Fever	6.7%
364	AIDS Dementia Complex	6.6%
365	Argyria	6.6%
366	Salmonella food poisoning	6.6%
367	Carpal Tunnel Syndrome	6.5%
368	Cluster Headache	6.5%
369	Migraine with Aura	6.5%
370	Familial Hemiplegic Migraine	6.5%
371	Chronic Paroxysmal Hemicrania	6.5%
372	SUNCT Syndrome	6.5%
373	Paroxysmal Hemicrania	6.5%
374	neurofibroma	6.5%
375	Sciatica	6.5%
376	Neuroaspergillosis	6.2%
377	Alstrom Syndrome	6.2%
378	Psychoses, Alcoholic	6.2%
379	Reflex, Abnormal	6.2%
380	Hyporeflexia	6.2%
381	Hyperreflexia	6.2%
382	Gait Apraxia	6.1%
383	Kernicterus	6.1%
384	Myositis	6%
385	Optic Atrophy	6%
386	Optic Neuritis	6%
387	Papilledema	6%
388	Strabismus	6%
389	Tolosa-Hunt Syndrome	6%
390	Isaacs syndrome	6%
391	Myotonic Disorders	6%
392	Myasthenic Syndromes, Congenital	6%
393	Carotid Stenosis	6%
394	Intracranial Aneurysm	6%
395	Intracranial Arteriosclerosis	5.9%
396	Cerebral Atherosclerosis	5.9%
397	Subarachnoid Hemorrhage	5.9%
398	Cerebral Arteriosclerosis	5.9%
399	Cerebral Hemorrhage	5.9%
400	Diabetic Neuropathies	5.9%
401	Facial Injuries	5.9%
402	Facial Neuralgia	5.9%
403	Diabetic Amyotrophy	5.9%
404	Diabetic Autonomic Neuropathy	5.9%
405	Sleep Talking	5.9%
406	Sleep Disorders, Intrinsic	5.9%
407	Orthostatic intolerance	5.9%
408	Cerebral Thrombosis	5.9%
409	Intracranial Embolism	5.9%
410	Intracranial Thrombosis	5.9%
411	Drug abuse	5.9%
412	Substance Dependence	5.9%
413	Substance-Related Disorders	5.9%
414	Drug Dependence	5.9%
415	Anosmia	5.9%
416	Ataxia	5.9%
417	Athetosis	5.9%
418	Catalepsy	5.9%
419	Dystonia	5.9%
420	Hemiplegia	5.9%
421	Locked-In Syndrome	5.9%
422	Meningeal Neoplasms	5.9%
423	Meningomyelocele	5.9%
424	Muscle Hypertonia	5.9%
425	Muscle hypotonia	5.9%
426	Myoclonus	5.9%
427	Myotonia	5.9%
428	Neuralgia	5.9%
429	Paraplegia	5.9%
430	Pseudobulbar Palsy	5.9%
431	Quadriplegia	5.9%
432	Spasm	5.9%
433	Spastic Paraplegia	5.9%
434	Status Epilepticus	5.9%
435	Taste Disorders	5.9%
436	Tremor	5.9%
437	Spina Bifida	5.9%
438	Monoplegia	5.9%
439	Hypokinesia	5.9%
440	Paraparesis	5.9%
441	Bradykinesia	5.9%
442	Waxy flexibility	5.9%
443	Action Tremor	5.9%
444	Resting Tremor	5.9%
445	Dysosmia	5.9%
446	Quadriparesis	5.9%
447	Olfaction Disorders	5.9%
448	Myokymia	5.9%
449	Vestibular Neuronitis	5.9%
450	Somatosensory Disorders	5.9%
451	Neuropathic pain	5.9%
452	Hyperkinesia	5.9%
453	Intention tremor	5.9%
454	Cubital Tunnel Syndrome	5.8%
455	Hematoma, Subdural	5.8%
456	Hematoma, Epidural, Cranial	5.8%
457	Pseudorabies	5.7%
458	Amyloid Neuropathies, Familial	5.5%
459	Hyperprolactinemia	5.5%
460	Subclavian Steal Syndrome	5.4%
461	Pick Disease of the Brain	5.4%
462	Neurosyphilis	5.4%
463	Acoustic Neuroma	5.4%
464	Anterior Spinal Artery Syndrome	5.3%
465	Hand-Arm Vibration Syndrome	5.3%
466	Vision Disorders	5.2%
467	Metamorphopsia	5.2%
468	Visual Impairment	5.2%
469	Fibromyalgia	5.2%
470	Optic Neuropathy, Ischemic	5.2%
471	Anterior Ischemic Optic Neuropathy	5.2%
472	Medial Tibial Stress Syndrome	5.2%
473	Carotid Artery Thrombosis	5.2%
474	Facial Hemiatrophy	5.1%
475	Melkersson-Rosenthal Syndrome	5.1%
476	Mitochondrial Myopathies	5.1%
477	Anisocoria	5.1%
478	Confusion	5.1%
479	Facial paralysis	5.1%
480	Lethargy	5.1%
481	Memory Disorders	5.1%
482	Muscle Cramp	5.1%
483	Perceptual Disorders	5.1%
484	Psychomotor Disorders	5.1%
485	Tonic Pupil	5.1%
486	Eosinophilia-Myalgia Syndrome	5.1%
487	Anhedonia	5.1%
488	Disorientation	5.1%
489	Facial Paresis	5.1%
490	Memory Loss	5.1%
491	Hemisensory Neglect	5.1%
492	Dysacusis	5.1%
493	Sciatic Neuropathy	5.1%
494	Ulnar Neuropathies	5.1%
495	Lesion of Sciatic Nerve	5.1%
496	Ulnar Neuritis	5.1%
497	Radial nerve compression	5.1%
498	Radial Tunnel Syndrome	5.1%
499	Peroneal Neuropathies	5.1%
500	Radial Neuropathy	5.1%
501	Median Neuropathy	5.1%
502	Sciatic Nerve Palsy	5.1%
503	Femoral Neuropathy	5.1%
504	Tibial Neuropathy	5.1%
505	Ulnar Nerve Palsy	5.1%
506	Postural Orthostatic Tachycardia Syndrome	5.1%
507	Radial nerve palsy	5.1%
508	Sleep Bruxism	5.1%
509	Anencephaly	5.1%
510	Meningocele	5.1%
511	Muscular Atrophy	5.1%
512	Respiratory Paralysis	5.1%
513	Encephalocele	5.1%
514	Tetany	5%
515	Classical Lissencephalies and Subcortical Band Heterotopias	5%
516	Tick Paralysis	4.9%
517	Lyme Neuroborreliosis	4.8%
518	Hematoma, Subdural, Intracranial	4.8%
519	Hematoma, Subdural, Chronic	4.8%
520	Hematoma, Subdural, Acute	4.8%
521	Acromegaly	4.7%
522	Cerebral Amyloid Angiopathy	4.6%
523	Sinus Thrombosis, Intracranial	4.6%
524	Toxoplasmosis, Congenital	4.6%
525	Malaria, Cerebral	4.6%
526	Neurocysticercosis	4.6%
527	Duane Retraction Syndrome	4.5%
528	Consciousness Disorders	4.5%
529	Mental Retardation	4.5%
530	Muscle Weakness	4.5%
531	Depressed Level of Consciousness	4.5%
532	Mental deficiency	4.5%
533	Intellectual Disability	4.5%
534	Alexia	4.5%
535	Dyslexia	4.5%
536	Mobius Syndrome	4.5%
537	Bell Palsy	4.5%
538	Catatonia	4.5%
539	Herpes Zoster Oticus	4.5%
540	Familial Periodic Paralysis	4.5%
541	Aphonia	4.4%
542	Sleep Deprivation	4.4%
543	Dysphonia	4.4%
544	Waterhouse-Friderichsen Syndrome	4.4%
545	Menkes Kinky Hair Syndrome	4.4%
546	Kearns-Sayre syndrome	4.3%
547	Thoracic Outlet Syndrome	4.3%
548	Fabry Disease	4.3%
549	Esotropia	4.3%
550	Exotropia	4.3%
551	Hypotension, Orthostatic	4.3%
552	Sleep Apnea Syndromes	4.3%
553	Polymyositis	4.3%
554	Post-Exercise Hypotension	4.3%
555	Disorders of Excessive Somnolence	4.2%
556	Sleep Initiation and Maintenance Disorders	4.2%
557	Night Terrors	4.2%
558	Somnambulism	4.2%
559	Trigeminal Nerve Disorder	4.2%
560	Transient Insomnia	4.2%
561	Sleep Paralysis	4.2%
562	Chronic Insomnia	4.2%
563	REM Sleep Behavior Disorder	4.2%
564	Hypersomnia	4.2%
565	Dermal Sinus	4.2%
566	Dysgeusia	4.2%
567	Formication	4.2%
568	Hyperalgesia	4.2%
569	Hyperesthesia	4.2%
570	Hypesthesia	4.2%
571	Language Disorders	4.2%
572	Numbness	4.2%
573	Paresthesia	4.2%
574	Paraparesis, Spastic	4.2%
575	Spina Bifida Cystica	4.2%
576	Trismus	4.2%
577	Spina Bifida Occulta	4.2%
578	Epilepsia Partialis Continua	4.2%
579	Hypogeusia	4.2%
580	Meningeal Carcinomatosis	4.2%
581	Brown-Sequard Syndrome	4.2%
582	Lissencephaly	4.2%
583	Polymicrogyria	4.2%
584	Pachygyria	4.2%
585	Schizencephaly	4.2%
586	Lockjaw	4.2%
587	Allodynia	4.2%
588	Periventricular Nodular Heterotopia	4.2%
589	Ageusia	4.2%
590	Neurofibrosarcoma	4.2%
591	Optic Atrophy, Hereditary, Leber	4.2%
592	Galactosemias	4.1%
593	Urea Cycle Disorders, Inborn	4.1%
594	Tyrosinemias	4.1%
595	Polyradiculopathy	4.1%
596	Anticholinergic Syndrome	4%
597	Serotonin Syndrome	4%
598	Propofol Infusion Syndrome	4%
599	Cavernous Sinus Thrombosis	4%
600	Sagittal Sinus Thrombosis	4%
601	Myalgia	3.9%
602	Neuronal Ceroid-Lipofuscinoses	3.9%
603	Homocystinuria	3.8%
604	Leigh Disease	3.8%
605	Eye Injuries	3.7%
606	Muscular Dystrophy	3.7%
607	Congenital nystagmus	3.7%
608	Orbital Myositis	3.7%
609	Diplopia	3.7%
610	Muscle Rigidity	3.7%
611	Muscle Spasticity	3.7%
612	Scotoma	3.7%
613	Photophobia	3.7%
614	Cogwheel Rigidity	3.7%
615	Hemifacial Spasm	3.7%
616	Amaurosis	3.7%
617	Blindness	3.7%
618	Nuchal Rigidity	3.7%
619	Pyomyositis	3.7%
620	Prolactinoma	3.6%
621	Growth Hormone-Secreting Pituitary Adenoma	3.6%
622	Agnosia	3.6%
623	Apraxias	3.6%
624	Hallucinations	3.6%
625	Hemianopsia	3.6%
626	Hyperacusis	3.6%
627	Tinnitus	3.6%
628	Visual Agnosia	3.6%
629	Anosognosia	3.6%
630	Wernicke-Korsakoff Syndrome	3.6%
631	Phonophobia	3.6%
632	Hearing Loss	3.6%
633	Sarcopenia	3.6%
634	Aicardi's syndrome	3.6%
635	Hoarseness	3.6%
636	Cockayne Syndrome	3.6%
637	Nelson Syndrome	3.5%
638	Sleep Apnea, Obstructive	3.4%
639	Sleep Apnea, Central	3.4%
640	Narcolepsy	3.4%
641	Trigeminal Neuralgia	3.4%
642	Kleine-Levin Syndrome	3.4%
643	Agraphia	3.4%
644	Anomia	3.4%
645	Cluttering	3.4%
646	Language Development Disorders	3.4%
647	Speech Disorders	3.4%
648	Syncope	3.4%
649	Stupor	3.4%
650	Dysgraphia	3.4%
651	Presyncope	3.4%
652	Dyslalia	3.4%
653	Marijuana Abuse	3.4%
654	Opioid-Related Disorders	3.4%
655	Nicotine Dependence	3.4%
656	Opioid abuse	3.4%
657	Phencyclidine Abuse	3.4%
658	Substance Abuse, Intravenous	3.4%
659	Substance Withdrawal Syndrome	3.4%
660	Tobacco Use Disorder	3.4%
661	Alcohol-Related Disorders	3.4%
662	Amphetamine-Related Disorders	3.4%
663	Cocaine-Related Disorders	3.4%
664	Metabolic Side Effects of Drugs and Substances	3.4%
665	Injection Site Reaction	3.3%
666	Infusion site reaction	3.3%
667	Drug Overdose	3.3%
668	Holoprosencephaly	3.2%
669	Amnesia	3.2%
670	Delirium	3.2%
671	Dissociative Amnesia	3.2%
672	Color blindness	3.2%
673	Global Amnesia	3.2%
674	Cri-du-Chat Syndrome	3.2%
675	Down Syndrome	3.2%
676	Trisomy 21	3.2%
677	POEMS Syndrome	3.2%
678	Meningioma	3.2%
679	Williams Syndrome	3.2%
680	Microcephaly	3.2%
681	Macrocephaly	3.2%
682	Hypokalemic periodic paralysis	3.2%
683	Porencephaly	3.1%
684	Zellweger Syndrome	3%
685	Cataplexy	3%
686	Aphasia	3%
687	Articulation Disorders	3%
688	Echolalia	3%
689	Stuttering	3%
690	Dysphasia	3%
691	Eye Burns	2.9%
692	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.9%
693	Welander Distal Myopathy	2.9%
694	Neonatal Abstinence Syndrome	2.9%
695	Amaurosis Fugax	2.9%
696	Blindness, Cortical	2.9%
697	Dyscalculia	2.9%
698	Rett Syndrome	2.9%
699	Deafness	2.9%
700	Hearing Loss, Sudden	2.9%
701	Gerstmann Syndrome	2.9%
702	Hearing Loss, Bilateral	2.9%
703	Hearing Loss, High-Frequency	2.9%
704	Hearing Loss, Mixed Conductive-Sensorineural	2.9%
705	Prosopagnosia	2.9%
706	Apraxia, Ideomotor	2.9%
707	Charles Bonnet Syndrome	2.9%
708	Hearing Loss, Unilateral	2.9%
709	Complete Hearing Loss	2.9%
710	Alien Hand Syndrome	2.9%
711	Deaf Mutism	2.9%
712	Prader-Willi Syndrome	2.8%
713	Phantom pain	2.8%
714	Phantom Limb Pain	2.8%
715	Dysarthria	2.8%
716	Glycogen storage disease type II	2.7%
717	Alcohol-Induced Disorders	2.6%
718	Dermatomyositis	2.6%
719	Corneal Scar	2.6%
720	Mutism	2.6%
721	Selective Mutism	2.6%
722	Muscular Dystrophy, Duchenne	2.6%
723	Retrograde amnesia	2.5%
724	Amnesia, Anterograde	2.5%
725	Cardiotoxicity	2.5%
726	Alexia, Pure	2.4%
727	Rubinstein-Taybi Syndrome	2.3%
728	Fragile X Syndrome	2.3%
729	Corneal Perforation	2.2%
730	Alcohol Use Disorder	2.2%
731	Alcoholic Intoxication	2.2%
732	Heroin Dependence	2.2%
733	Morphine Dependence	2.2%
734	Alcohol abuse	2.2%
735	Gaucher Disease	2.1%
736	Drug Eruptions	1.9%
737	Binge Drinking	1.9%
738	Tay-Sachs Disease	1.9%
739	Niemann-Pick Disease, Type C	1.8%
740	Mucopolysaccharidosis II	1.7%
741	Cardiomyopathy, Alcoholic	1.6%
742	Pancreatitis, Alcoholic	1.6%
743	Asthma, Aspirin-Induced	1.5%
744	Fetal Alcohol Spectrum Disorders	1.4%
745	Acute Generalized Exanthematous Pustulosis	1.4%
746	Erythema Nodosum	1.2%
747	Serum Sickness	1.2%
748	Fatty Liver, Alcoholic	1.2%
749	Hepatitis, Alcoholic	1.2%
750	Liver Cirrhosis, Alcoholic	1.2%
751	Toxic Epidermal Necrolysis	1%
752	Stevens-Johnson Syndrome	1%

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