MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Syringomyelia

(UMLS:C0039144)

Definition:: Longitudinal cavities in the spinal cord, most often in the cervical region, which may extend for multiple spinal levels. The cavities are lined by dense, gliogenous tissue and may be associated with SPINAL CORD NEOPLASMS; spinal cord traumatic injuries; and vascular malformations. Syringomyelia is marked clinically by pain and PARESTHESIA, muscular atrophy of the hands, and analgesia with thermoanesthesia of the hands and arms, but with the tactile sense preserved (sensory dissociation). Lower extremity spasticity and incontinence may also develop. (From Adams et al., Principles of Neurology, 6th ed, p1269)
UMLS ID:: C0039144
MeSH ID:: D013595

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.854.833

Synonym(s)

Syringomyelia

Fluid-filled cyst in spinal cord

Myelosyringosis

SYRINGOMYELIA

Spinal cord cavitation

Syringomyelia-anaesthesia syndrome

Syringomyelia-anesthesia syndrome

Syrinx

syringomyelia

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 10	US FAERS
2	Alendronate	FAERS: 6	US FAERS
3	Lidoderm	FAERS: 6	US FAERS
4	Baclofen	FAERS: 4	US FAERS
5	Glatiramer Acetate	FAERS: 3	US FAERS
6	Valproic Acid	FAERS: 3	US FAERS
7	Iophendylate	FAERS: 2	US FAERS
8	Pregabalin	FAERS: 2	US FAERS
9	Teriparatide	FAERS: 2	US FAERS
10	Valproic Acid	FAERS: 2	US FAERS
11	rofecoxib	FAERS: 2	US FAERS
12	4-Aminopyridine	FAERS: 1	US FAERS
13	Capsaicin	FAERS: 1	US FAERS
14	Carbamazepine	FAERS: 1	US FAERS
15	Citalopram	FAERS: 1	US FAERS
16	Dimethyl Fumarate	FAERS: 1	US FAERS
17	Fenofibrate	FAERS: 1	US FAERS
18	Fingolimod Hydrochloride	FAERS: 1	US FAERS
19	Imatinib Mesylate	FAERS: 1	US FAERS
20	Lidocaine	FAERS: 1	US FAERS
21	NuvaRing	FAERS: 1	US FAERS
22	Oxycodone	FAERS: 1	US FAERS
23	Quetiapine Fumarate	FAERS: 1	US FAERS
24	Simvastatin	FAERS: 1	US FAERS
25	Tadalafil	FAERS: 1	OFFSIDES US FAERS
26	Topiramate	FAERS: 1	US FAERS
27	Triamcinolone Acetonide	FAERS: 1	US FAERS
28	bicalutamide	FAERS: 1	US FAERS
29	trametinib	FAERS: 1	US FAERS
30	Finasteride		OFFSIDES
31	Ipratropium		OFFSIDES
32	Niacin		OFFSIDES
33	Nicotine		OFFSIDES
34	Penicillin V		OFFSIDES
35	Ribavirin		OFFSIDES
36	Rocuronium		OFFSIDES
37	Tretinoin		OFFSIDES
38	Zoledronic Acid		OFFSIDES
39	chlorhexidine gluconate		OFFSIDES
40	cyclobenzaprine		OFFSIDES
41	olsalazine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Pneumorrhachis	46.7%
2	Myelitis	44.4%
3	Encephalomyelitis	34.1%
4	Epidural Abscess	32.2%
5	Conus Medullaris Syndrome	31.8%
6	Spinal Cord Vascular Diseases	31.8%
7	Brain Diseases	31%
8	Meningitis	31%
9	Movement Disorders	31%
10	Pachymeningitis	31%
11	Spinal Cord Injuries	30.4%
12	Spinal Muscular Atrophy	30%
13	Progressive Muscular Atrophy	30%
14	Meningoencephalitis	27.6%
15	Stiff-Person Syndrome	27.4%
16	Spinal Cord Neoplasms	26.4%
17	Poliomyelitis	23.8%
18	Subdural Effusion	23.1%
19	Parkinsonian Disorders	23.1%
20	Spinal Cord Ischemia	23.1%
21	Subacute Combined Degeneration	22.5%
22	Amyotrophic Lateral Sclerosis	22.1%
23	Central Nervous System Infection	22%
24	Ocular Motility Disorders	21.8%
25	Cyclophoria	21.8%
26	Central Cord Syndrome	21%
27	Multiple System Atrophy	20.8%
28	Prion Diseases	20.5%
29	Akinetic Mutism	20%
30	Anoxic Encephalopathy	20%
31	Arachnoiditis	20%
32	Basal Ganglia Diseases	20%
33	Brain Damage, Chronic	20%
34	Cerebellar Diseases	20%
35	Encephalitis	20%
36	Encephalomalacia	20%
37	Epilepsy	20%
38	Hydrocephalus	20%
39	Congenital Hydrocephalus	20%
40	Hypothalamic Diseases	20%
41	Aseptic Meningitis	20%
42	Thalamic Diseases	20%
43	Intracranial Hypertension	20%
44	Aura	20%
45	Leukoencephalopathy	20%
46	Essential Tremor	20%
47	Neuroaxonal Dystrophies	20%
48	Familial Tremor	20%
49	Headache Disorders	20%
50	Intracranial Hypotension	20%
51	Brain Edema	20%
52	Brain Hypoxia	20%
53	Aqueductal Stenosis	20%
54	Writer's Cramp	20%
55	Pneumocephalus	19.9%
56	Meige Syndrome	19.6%
57	Cerebral Ventriculitis	19.6%
58	Anterior Spinal Artery Syndrome	18.9%
59	Parkinson Disease	18.7%
60	Cranial nerve diseases	18.5%
61	Demyelinating Diseases	18.5%
62	Demyelination	18.5%
63	Neuromuscular Diseases	18.5%
64	Chronobiology Disorders	18.5%
65	Posterior Leukoencephalopathy Syndrome	17.8%
66	Posterior reversible encephalopathy syndrome	17.8%
67	Meningitis, Bacterial	17.4%
68	Meningitis, Fungal	17.4%
69	Lewy Body Disease	17.4%
70	Friedreich Ataxia	17.1%
71	Marchiafava-Bignami Disease	16.9%
72	Myoclonic Epilepsy	16.1%
73	Epilepsy, Temporal Lobe	16.1%
74	Epilepsy, Rolandic	16.1%
75	Benign Rolandic Epilepsy	16.1%
76	Brain Abscess	16.1%
77	Dandy-Walker Syndrome	16%
78	Myelitis, Transverse	15.3%
79	Striatonigral Degeneration	15.3%
80	Asterixis	15.3%
81	Ballismus	15.3%
82	Cerebral Palsy	14.8%
83	Epilepsies, Partial	14.8%
84	Epilepsy, Generalized	14.8%
85	Creutzfeldt-Jakob disease	14.8%
86	Pseudotumor Cerebri	14.8%
87	Hypertensive Encephalopathy	14.8%
88	Simple Partial Seizures	14.8%
89	Epilepsy, Reflex	14.8%
90	Basal Ganglia Cerebrovascular Disease	14.8%
91	Headache Disorders, Primary	14.8%
92	Headache Disorders, Secondary	14.8%
93	Medication overuse headache	14.8%
94	Dystonia Musculorum Deformans	14.5%
95	Juvenile Myoclonic Epilepsy	14.4%
96	Myoclonic Epilepsies, Progressive	14.4%
97	Motor Neuron Disease	14%
98	Brain Diseases, Metabolic	13.6%
99	Cerebrovascular Disorders	13.6%
100	Epilepsy, Post-Traumatic	13.6%
101	Cerebrovascular Insufficiency	13.6%
102	Dementia	13.6%
103	Central Nervous System Fungal Infections	13.6%
104	Dementia, Vascular	13.6%
105	Vascular Headaches	13.5%
106	MPTP Poisoning	13.4%
107	Hypoxia-Ischemia, Brain	13.4%
108	Brain Injuries	13.3%
109	Brain Neoplasms	13.2%
110	Chronic Fatigue Syndrome	12.9%
111	Tuberculosis, Meningeal	12.8%
112	Trauma, Nervous System	12.8%
113	Shy-Drager Syndrome	12.8%
114	Progressive supranuclear palsy	12.7%
115	Neuroleptic Malignant Syndrome	12.6%
116	Myelinolysis, Central Pontine	12.6%
117	Leukoencephalopathy, Progressive Multifocal	12.3%
118	Cerebellar Neoplasms	12.2%
119	Nervous System Neoplasms	12.2%
120	Neurologic Manifestations	12.2%
121	Post-Traumatic Headache	12.2%
122	Tension Headache	12.2%
123	Epilepsy, Complex Partial	12.2%
124	Migraine Disorders	12.2%
125	Neurotoxicity Syndromes	12.2%
126	Abdominal Migraine	12.2%
127	Status Migrainosus	12.2%
128	Cervicogenic Headache	12.2%
129	Huntington Disease	12.1%
130	Lupus Vasculitis, Central Nervous System	12%
131	Limbic Encephalitis	12%
132	Leukomalacia, Periventricular	11.8%
133	Brain Death	11.7%
134	Autonomic Dysreflexia	11.4%
135	Complex Regional Pain Syndromes	11.4%
136	Cluster Headache	10.9%
137	Migraine with Aura	10.9%
138	Familial Hemiplegic Migraine	10.9%
139	Chronic Paroxysmal Hemicrania	10.9%
140	SUNCT Syndrome	10.9%
141	Paroxysmal Hemicrania	10.9%
142	Scrapie	10.9%
143	Lafora Disease	10.9%
144	Unverricht-Lundborg Syndrome	10.9%
145	Meningitis, Cryptococcal	10.7%
146	Presenile dementia	10.7%
147	Senile dementia	10.7%
148	Meningitis, Listeria	10.7%
149	Chorea	10.7%
150	Meningitis, Haemophilus	10.6%
151	Meningitis, Pneumococcal	10.6%
152	Pituitary Diseases	10.6%
153	Toxoplasmosis, Cerebral	10.4%
154	Dysautonomia	10.3%
155	Vagus Nerve Disorder	10.3%
156	Glossopharyngeal Neuralgia	10.3%
157	Abducens Nerve Diseases	10.3%
158	Heavy Metal Poisoning, Nervous System	10.3%
159	Neuromuscular Junction Diseases	10.3%
160	Central Nervous System Bacterial Infections	10.3%
161	Tauopathies	10.3%
162	Trochlear Nerve Diseases	10.3%
163	Peripheral Nervous System Diseases	10.3%
164	Ophthalmoplegic Migraine	10.3%
165	Polyradiculoneuropathy	10.2%
166	Polyradiculoneuritis	10.2%
167	Leukoencephalitis, Acute Hemorrhagic	10.2%
168	Encephalomyelitis, Acute Disseminated	10.2%
169	Akathisia, Drug-Induced	10.1%
170	Amblyopia	10%
171	Basal Ganglia Hemorrhage	9.9%
172	Carotid Artery Diseases	9.9%
173	Brain Ischemia	9.9%
174	Cerebrovascular accident	9.9%
175	Kluver-Bucy Syndrome	9.9%
176	Vasospasm, Intracranial	9.9%
177	Intracranial Arterial Diseases	9.9%
178	Pituitary Apoplexy	9.9%
179	Brain Injuries, Diffuse	9.8%
180	Traumatic Brain Injury	9.8%
181	Cerebellar Ataxia	9.7%
182	Supratentorial Neoplasms	9.7%
183	Torticollis	9.7%
184	Tuberculosis, Central Nervous System	9.7%
185	Brain Infarction	9.7%
186	Restless Legs Syndrome	9.7%
187	Opsoclonus-Myoclonus Syndrome	9.6%
188	Sleep Wake Disorders	9.3%
189	Persistent Vegetative State	9.3%
190	Dyskinesia, Drug-Induced	9.1%
191	Putaminal Hemorrhage	9%
192	Subacute Sclerosing Panencephalitis	9%
193	Hepatolenticular Degeneration	8.9%
194	Progressive bulbar palsy	8.9%
195	Bulbar palsy	8.9%
196	Infarction, Middle Cerebral Artery	8.8%
197	Infarction, Anterior Cerebral Artery	8.8%
198	Infarction, Posterior Cerebral Artery	8.8%
199	Carotid Artery Injuries	8.8%
200	Miller Fisher Syndrome	8.8%
201	Brain Hemorrhage, Traumatic	8.8%
202	Pituitary Adenoma	8.7%
203	Pituitary Neoplasms	8.7%
204	Cerebral Infarction	8.6%
205	Brain Stem Infarctions	8.6%
206	Peripheral Nerve Injuries	8.6%
207	Paraneoplastic Cerebellar Degeneration	8.6%
208	Myasthenia Gravis	8.5%
209	Tardive Dyskinesia	8.5%
210	Empty Sella Syndrome	8.4%
211	Hyperpituitarism	8.4%
212	Hypopituitarism	8.4%
213	Hypophysitis	8.4%
214	Vasculitis, Central Nervous System	8.4%
215	Causalgia	8.2%
216	Cerebral Arterial Diseases	8.1%
217	Vertebrobasilar Insufficiency	8.1%
218	Lateral Medullary Syndrome	8.1%
219	Basilar Artery Stenosis	8.1%
220	Vertebral Artery Stenosis	8.1%
221	Intracranial Hemorrhage, Hypertensive	8.1%
222	Transient Cerebral Ischemia	8.1%
223	Diffuse Axonal Injury	8%
224	Brain Stem Neoplasms	8%
225	Canavan Disease	8%
226	Alexander Disease	8%
227	Guillain-Barre Syndrome	7.9%
228	Amnesia, Transient Global	7.9%
229	Reflex Sympathetic Dystrophy	7.7%
230	Nocturnal Myoclonus Syndrome	7.7%
231	Moyamoya Disease	7.7%
232	Reye Syndrome	7.4%
233	Neuroaspergillosis	7.4%
234	Intracranial Embolism and Thrombosis	7.4%
235	Hepatic Encephalopathy	7.4%
236	Hyperprolactinemia	7.4%
237	Myopathy	7.3%
238	Optic Neuropathy	7.3%
239	Subclavian Steal Syndrome	7.2%
240	Pick Disease of the Brain	7.2%
241	Olfactory Nerve Injuries	7.2%
242	Choroid Plexus Papilloma	7.2%
243	West Nile Fever	7.2%
244	Sleep Disorders, Circadian Rhythm	7%
245	Facial Nerve Diseases	7%
246	Craniocerebral Trauma	7%
247	Parasomnia	7%
248	Dyssomnias	7%
249	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.9%
250	Vestibulocochlear Nerve Diseases	6.8%
251	Decerebrate State	6.8%
252	Hemiparesis	6.8%
253	Hydranencephaly	6.8%
254	Meningism	6.8%
255	Neural Tube Defects	6.8%
256	Paresis	6.8%
257	Seizures	6.8%
258	Sensation Disorders	6.8%
259	Tethered Cord Syndrome	6.8%
260	Central Nervous System Neoplasms	6.8%
261	Complex partial seizures	6.8%
262	Iniencephaly	6.8%
263	Craniorachischisis	6.8%
264	Exencephaly	6.8%
265	Monoparesis	6.8%
266	Septo-Optic Dysplasia	6.8%
267	Cortical Dysplasia	6.8%
268	Neurogenic Inflammation	6.8%
269	Gait Disorders, Neurologic	6.8%
270	Neuromuscular Manifestations	6.8%
271	Malformations of Cortical Development	6.8%
272	Frontotemporal dementia	6.8%
273	Sweating, Gustatory	6.7%
274	Auriculotemporal Syndrome	6.7%
275	Botulism	6.7%
276	Central Nervous System Cysts	6.7%
277	Lambert-Eaton Myasthenic Syndrome	6.7%
278	Neuritis	6.7%
279	Polyneuritis	6.7%
280	Radiculitis	6.7%
281	Polyneuropathy	6.7%
282	Mononeuritis	6.7%
283	Mononeuropathies	6.7%
284	Brachial Plexus Neuropathies	6.7%
285	Radiculopathy	6.7%
286	Mononeuropathy Multiplex	6.7%
287	Nerve Root Compression	6.7%
288	Subarachnoid Hemorrhage, Traumatic	6.6%
289	Carotid Artery, Internal, Dissection	6.6%
290	Multiple Sclerosis	6.6%
291	Mitochondrial Encephalomyopathies	6.6%
292	Brachial Plexus Neuritis	6.5%
293	Neuralgic Amyotrophy	6.5%
294	Brain Contusion	6.5%
295	Ataxia Telangiectasia	6.3%
296	Pseudorabies	6.3%
297	Vertebral Artery Dissection	6.3%
298	Toxoplasmosis, Congenital	6.2%
299	Malaria, Cerebral	6.2%
300	Neuromyelitis Optica	6.2%
301	Carotid Stenosis	6.1%
302	Intracranial Aneurysm	6.1%
303	Neurocysticercosis	6.1%
304	Intracranial Arteriosclerosis	6.1%
305	Cerebral Atherosclerosis	6.1%
306	Subarachnoid Hemorrhage	6.1%
307	Cerebral Arteriosclerosis	6.1%
308	Cerebral Hemorrhage	6.1%
309	Cerebral Thrombosis	6%
310	Intracranial Embolism	6%
311	Intracranial Thrombosis	6%
312	Facial Nerve Injuries	6%
313	Brain Concussion	6%
314	Horner Syndrome	6%
315	Brain Diseases, Metabolic, Inborn	6%
316	Tarsal Tunnel Syndrome	5.9%
317	Cauda Equina Syndrome	5.9%
318	Alice in Wonderland Syndrome	5.9%
319	Neurosyphilis	5.8%
320	Acrodynia	5.7%
321	MELAS Syndrome	5.6%
322	Auditory Perceptual Disorders	5.6%
323	Acromegaly	5.5%
324	Cerebral Amyloid Angiopathy	5.4%
325	Sinus Thrombosis, Intracranial	5.4%
326	Ophthalmoplegia	5.4%
327	External Ophthalmoplegia	5.4%
328	Pupil Disorders	5.4%
329	Neurobehavioral Manifestations	5.4%
330	Adrenoleukodystrophy	5.4%
331	Paraneoplastic Encephalomyelitis	5.2%
332	Charcot-Marie-Tooth Disease	5.1%
333	Myasthenia Gravis, Autoimmune, Experimental	5.1%
334	Coma, Post-Head Injury	5.1%
335	Uveomeningoencephalitic Syndrome	5.1%
336	Cavernous Sinus Thrombosis	5.1%
337	Sagittal Sinus Thrombosis	5.1%
338	Sturge-Weber Syndrome	5%
339	Vertigo	5%
340	Alcohol-Induced Disorders, Nervous System	5%
341	Jet Lag Syndrome	5%
342	Wernicke Encephalopathy	4.9%
343	Sciatic Neuropathy	4.9%
344	Ulnar Neuropathies	4.9%
345	Lesion of Sciatic Nerve	4.9%
346	Ulnar Neuritis	4.9%
347	Radial nerve compression	4.9%
348	Radial Tunnel Syndrome	4.9%
349	Peroneal Neuropathies	4.9%
350	Radial Neuropathy	4.9%
351	Median Neuropathy	4.9%
352	Sciatic Nerve Palsy	4.9%
353	Femoral Neuropathy	4.9%
354	Tibial Neuropathy	4.9%
355	Ulnar Nerve Palsy	4.9%
356	Postural Orthostatic Tachycardia Syndrome	4.9%
357	Radial nerve palsy	4.9%
358	AIDS Dementia Complex	4.9%
359	Multiple Sclerosis, Chronic Progressive	4.9%
360	Multiple Sclerosis, Relapsing-Remitting	4.9%
361	Lyme Neuroborreliosis	4.9%
362	Carotid Artery Thrombosis	4.8%
363	Giant Cell Arteritis	4.7%
364	Temporal Arteritis	4.7%
365	Myotonia Congenita	4.6%
366	Waterhouse-Friderichsen Syndrome	4.6%
367	Refsum Disease	4.6%
368	Cerebrospinal Fluid Otorrhea	4.6%
369	Cerebrospinal Fluid Rhinorrhea	4.6%
370	Neuritis, Autoimmune, Experimental	4.6%
371	Gait Ataxia	4.6%
372	Myositis	4.5%
373	Optic Atrophy	4.5%
374	Optic Neuritis	4.5%
375	Papilledema	4.5%
376	Strabismus	4.5%
377	Tolosa-Hunt Syndrome	4.5%
378	Isaacs syndrome	4.5%
379	Arsenic Poisoning	4.5%
380	Myotonic Disorders	4.5%
381	Myasthenic Syndromes, Congenital	4.5%
382	Vocal Cord Paralysis	4.5%
383	Carpal Tunnel Syndrome	4.5%
384	Hematoma, Subdural	4.5%
385	Hematoma, Epidural, Cranial	4.5%
386	neurofibroma	4.5%
387	Diabetic Neuropathies	4.4%
388	Facial Injuries	4.4%
389	Facial Neuralgia	4.4%
390	Diabetic Amyotrophy	4.4%
391	Diabetic Autonomic Neuropathy	4.4%
392	Sleep Talking	4.4%
393	Manganese Poisoning	4.4%
394	Sleep Disorders, Intrinsic	4.4%
395	Orthostatic intolerance	4.4%
396	Sciatica	4.4%
397	Tuberous Sclerosis	4.4%
398	Anosmia	4.4%
399	Ataxia	4.4%
400	Athetosis	4.4%
401	Catalepsy	4.4%
402	Dystonia	4.4%
403	Hemiplegia	4.4%
404	Locked-In Syndrome	4.4%
405	Meningeal Neoplasms	4.4%
406	Meningomyelocele	4.4%
407	Muscle Hypertonia	4.4%
408	Muscle hypotonia	4.4%
409	Myoclonus	4.4%
410	Myotonia	4.4%
411	Neuralgia	4.4%
412	Paraplegia	4.4%
413	Pseudobulbar Palsy	4.4%
414	Quadriplegia	4.4%
415	Spasm	4.4%
416	Spastic Paraplegia	4.4%
417	Status Epilepticus	4.4%
418	Taste Disorders	4.4%
419	Tremor	4.4%
420	Spina Bifida	4.4%
421	Monoplegia	4.4%
422	Hypokinesia	4.4%
423	Paraparesis	4.4%
424	Bradykinesia	4.4%
425	Waxy flexibility	4.4%
426	Action Tremor	4.4%
427	Resting Tremor	4.4%
428	Dysosmia	4.4%
429	Quadriparesis	4.4%
430	Mercury Poisoning, Nervous System	4.4%
431	Olfaction Disorders	4.4%
432	Myokymia	4.4%
433	Lead Poisoning, Nervous System	4.4%
434	Vestibular Neuronitis	4.4%
435	Somatosensory Disorders	4.4%
436	Neuropathic pain	4.4%
437	Hyperkinesia	4.4%
438	Intention tremor	4.4%
439	Kernicterus	4.3%
440	Voice Disorders	4.2%
441	Voice Disturbance	4.2%
442	Nelson Syndrome	4.1%
443	Polyradiculopathy	4.1%
444	Smith-Magenis syndrome	4.1%
445	Hematoma, Subdural, Intracranial	4%
446	Hematoma, Subdural, Chronic	4%
447	Hematoma, Subdural, Acute	4%
448	Cubital Tunnel Syndrome	4%
449	Dural Arteriovenous Fistula	4%
450	Myotonic Dystrophy	3.9%
451	Akathisia	3.8%
452	Restlessness	3.8%
453	Psychomotor Agitation	3.8%
454	Alcohol Withdrawal Seizures	3.7%
455	Prolactinoma	3.7%
456	Growth Hormone-Secreting Pituitary Adenoma	3.7%
457	Hand-Arm Vibration Syndrome	3.6%
458	Gait Apraxia	3.5%
459	Vision Disorders	3.5%
460	Metamorphopsia	3.5%
461	Visual Impairment	3.5%
462	Galactosemias	3.5%
463	Urea Cycle Disorders, Inborn	3.5%
464	Tyrosinemias	3.5%
465	Fibromyalgia	3.4%
466	Optic Neuropathy, Ischemic	3.4%
467	Anterior Ischemic Optic Neuropathy	3.4%
468	Medial Tibial Stress Syndrome	3.4%
469	Fabry Disease	3.4%
470	Facial Hemiatrophy	3.4%
471	Melkersson-Rosenthal Syndrome	3.4%
472	Mitochondrial Myopathies	3.4%
473	Thoracic Outlet Syndrome	3.4%
474	Anisocoria	3.4%
475	Confusion	3.4%
476	Facial paralysis	3.4%
477	Lethargy	3.4%
478	Memory Disorders	3.4%
479	Muscle Cramp	3.4%
480	Perceptual Disorders	3.4%
481	Psychomotor Disorders	3.4%
482	Tonic Pupil	3.4%
483	Eosinophilia-Myalgia Syndrome	3.4%
484	Anhedonia	3.4%
485	Disorientation	3.4%
486	Facial Paresis	3.4%
487	Memory Loss	3.4%
488	Hemisensory Neglect	3.4%
489	Dysacusis	3.4%
490	Optic Nerve Glioma	3.4%
491	Sleep Bruxism	3.3%
492	Reflex, Abnormal	3.3%
493	Hyporeflexia	3.3%
494	Hyperreflexia	3.3%
495	Anencephaly	3.3%
496	Meningocele	3.3%
497	Muscular Atrophy	3.3%
498	Respiratory Paralysis	3.3%
499	Encephalocele	3.3%
500	Esotropia	3.3%
501	Exotropia	3.3%
502	Hypotension, Orthostatic	3.3%
503	Sleep Apnea Syndromes	3.3%
504	Polymyositis	3.3%
505	Post-Exercise Hypotension	3.3%
506	Tetany	3.3%
507	Disorders of Excessive Somnolence	3.3%
508	Sleep Initiation and Maintenance Disorders	3.3%
509	Night Terrors	3.3%
510	Somnambulism	3.3%
511	Trigeminal Nerve Disorder	3.3%
512	Transient Insomnia	3.3%
513	Sleep Paralysis	3.3%
514	Chronic Insomnia	3.3%
515	REM Sleep Behavior Disorder	3.3%
516	Hypersomnia	3.3%
517	Dermal Sinus	3.2%
518	Dysgeusia	3.2%
519	Formication	3.2%
520	Hyperalgesia	3.2%
521	Hyperesthesia	3.2%
522	Hypesthesia	3.2%
523	Language Disorders	3.2%
524	Numbness	3.2%
525	Paresthesia	3.2%
526	Paraparesis, Spastic	3.2%
527	Spina Bifida Cystica	3.2%
528	Trismus	3.2%
529	Spina Bifida Occulta	3.2%
530	Epilepsia Partialis Continua	3.2%
531	Hypogeusia	3.2%
532	Meningeal Carcinomatosis	3.2%
533	Brown-Sequard Syndrome	3.2%
534	Lissencephaly	3.2%
535	Polymicrogyria	3.2%
536	Pachygyria	3.2%
537	Schizencephaly	3.2%
538	Lockjaw	3.2%
539	Allodynia	3.2%
540	Lead Poisoning, Nervous System, Childhood	3.2%
541	Lead Poisoning, Nervous System, Adult	3.2%
542	Periventricular Nodular Heterotopia	3.2%
543	Ageusia	3.2%
544	Alstrom Syndrome	3.1%
545	Homocystinuria	3.1%
546	Leigh Disease	3%
547	Classical Lissencephalies and Subcortical Band Heterotopias	2.9%
548	Menkes Kinky Hair Syndrome	2.9%
549	Amyloid Neuropathies, Familial	2.8%
550	Duane Retraction Syndrome	2.7%
551	Consciousness Disorders	2.7%
552	Mental Retardation	2.7%
553	Muscle Weakness	2.7%
554	Depressed Level of Consciousness	2.7%
555	Mental deficiency	2.7%
556	Intellectual Disability	2.7%
557	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.7%
558	Mobius Syndrome	2.7%
559	Bell Palsy	2.7%
560	Sleep Apnea, Obstructive	2.7%
561	Sleep Apnea, Central	2.7%
562	Narcolepsy	2.7%
563	Trigeminal Neuralgia	2.7%
564	Kleine-Levin Syndrome	2.7%
565	Catatonia	2.7%
566	Agraphia	2.7%
567	Alexia	2.7%
568	Anomia	2.7%
569	Cluttering	2.7%
570	Language Development Disorders	2.7%
571	Speech Disorders	2.7%
572	Syncope	2.7%
573	Stupor	2.7%
574	Dysgraphia	2.7%
575	Dyslexia	2.7%
576	Presyncope	2.7%
577	Dyslalia	2.7%
578	Herpes Zoster Oticus	2.7%
579	Familial Periodic Paralysis	2.7%
580	Aphonia	2.6%
581	Sleep Deprivation	2.6%
582	Dysphonia	2.6%
583	Acoustic Neuroma	2.6%
584	Eye Injuries	2.6%
585	Neurofibrosarcoma	2.5%
586	Muscular Dystrophy	2.5%
587	Congenital nystagmus	2.5%
588	Orbital Myositis	2.5%
589	Diplopia	2.5%
590	Muscle Rigidity	2.5%
591	Muscle Spasticity	2.5%
592	Scotoma	2.5%
593	Photophobia	2.5%
594	Cogwheel Rigidity	2.5%
595	Hemifacial Spasm	2.5%
596	Amaurosis	2.5%
597	Blindness	2.5%
598	Nuchal Rigidity	2.5%
599	Pyomyositis	2.5%
600	Agnosia	2.4%
601	Apraxias	2.4%
602	Hallucinations	2.4%
603	Hemianopsia	2.4%
604	Hyperacusis	2.4%
605	Tinnitus	2.4%
606	Visual Agnosia	2.4%
607	Anosognosia	2.4%
608	Wernicke-Korsakoff Syndrome	2.4%
609	Phonophobia	2.4%
610	Hearing Loss	2.4%
611	Sarcopenia	2.4%
612	Cataplexy	2.4%
613	Aphasia	2.4%
614	Articulation Disorders	2.4%
615	Echolalia	2.4%
616	Stuttering	2.4%
617	Dysphasia	2.4%
618	Glycogen storage disease type II	2.4%
619	Dysarthria	2.3%
620	Optic Atrophy, Hereditary, Leber	2.2%
621	Zellweger Syndrome	2.2%
622	Myalgia	2.2%
623	Kearns-Sayre syndrome	2.2%
624	Neuronal Ceroid-Lipofuscinoses	2.2%
625	Eye Burns	2.1%
626	Welander Distal Myopathy	2%
627	Amaurosis Fugax	2%
628	Blindness, Cortical	2%
629	Dyscalculia	2%
630	Rett Syndrome	2%
631	Gaucher Disease	2%
632	Deafness	2%
633	Hearing Loss, Sudden	2%
634	Gerstmann Syndrome	2%
635	Hearing Loss, Bilateral	2%
636	Hearing Loss, High-Frequency	2%
637	Hearing Loss, Mixed Conductive-Sensorineural	2%
638	Prosopagnosia	2%
639	Apraxia, Ideomotor	2%
640	Charles Bonnet Syndrome	2%
641	Hearing Loss, Unilateral	2%
642	Complete Hearing Loss	2%
643	Alien Hand Syndrome	2%
644	Deaf Mutism	2%
645	Amnesia	2%
646	Delirium	2%
647	Dissociative Amnesia	2%
648	Color blindness	2%
649	Global Amnesia	2%
650	Cri-du-Chat Syndrome	2%
651	Down Syndrome	2%
652	Trisomy 21	2%
653	POEMS Syndrome	2%
654	Meningioma	2%
655	Williams Syndrome	2%
656	Microcephaly	2%
657	Macrocephaly	2%
658	Hypokalemic periodic paralysis	1.9%
659	Porencephaly	1.9%
660	Aicardi's syndrome	1.9%
661	Tay-Sachs Disease	1.9%
662	Hoarseness	1.9%
663	Cockayne Syndrome	1.9%
664	Alcohol Withdrawal Delirium	1.9%
665	Mutism	1.8%
666	Selective Mutism	1.8%
667	Niemann-Pick Disease, Type C	1.8%
668	Alexia, Pure	1.7%
669	Dermatomyositis	1.7%
670	Corneal Scar	1.7%
671	Holoprosencephaly	1.7%
672	Prader-Willi Syndrome	1.6%
673	Muscular Dystrophy, Duchenne	1.6%
674	Phantom pain	1.6%
675	Phantom Limb Pain	1.6%
676	Retrograde amnesia	1.6%
677	Amnesia, Anterograde	1.6%
678	Corneal Perforation	1.5%
679	Fragile X Syndrome	1.3%
680	Rubinstein-Taybi Syndrome	1.2%
681	Mucopolysaccharidosis II	0.9%

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