MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vasospasm, Intracranial

(UMLS:C0751895)

Definition:: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).
UMLS ID:: C0751895
MeSH ID:: D020301

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.300.900

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.253.951

Synonym(s)

Vasospasm, Intracranial

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aminocaproic Acid	6537999	CTD
2	Amphetamine	3356528 10765060 18634298	CTD
3	Bosentan	8587695 10353441	CTD
4	Bromocriptine	1923236	CTD
5	Buprenorphine	18332624	CTD
6	Calcium Compounds	8880753	CTD
7	Clobazam	16376047	CTD
8	Cocaine	View details 1420262 1486093 2124040 3603597 7762031 8138965 8880753 10765060 10815846 11481148 11588323 12924699 12935600 15926730	CTD
9	Colforsin	11958422	CTD
10	Cytarabine	17356399	CTD
11	Dexamethasone	17356399	CTD
12	Dexmedetomidine	20381357	CTD
13	Digitoxin	14574425	CTD
14	Dobutamine	10232545 19938664	CTD
15	Epoprostenol	19350202	CTD
16	Estradiol	17053178 18950269	CTD
17	Haloperidol	8138965	CTD
18	Ibuprofen	19057314	CTD
19	Indomethacin	8138965	CTD
20	Iohexol	1603313	CTD
21	Isoproterenol	11958422	CTD
22	Isradipine	12202012	CTD
23	Magnesium	8138965	CTD
24	Melatonin	19415488	CTD
25	Methamphetamine	2124040	CTD
26	Milrinone	18239182	CTD
27	Nicardipine	19057314	CTD
28	Nimodipine	3054619 3881564	CTD
29	Oxymetazoline	16200605	CTD
30	Papaverine	View details 7847211 7900600 8010275 9726476 11145478 18726058 19057314 19901231	CTD
31	Phenoxybenzamine	10953871	CTD
32	Phenylephrine	12015837	CTD
33	Phenytoin	16376047	CTD
34	Resveratrol	24602480	CTD
35	Rocuronium	18804883	CTD
36	Tetradecanoylphorbol Acetate	17105827	CTD
37	Verapamil	8138965 17445610 20705701	CTD
38	Vincristine	17356399	CTD
39	carbidopa, levodopa drug combination	11481148	CTD
40	fasudil	19057314 21615130	CTD
41	pifithrin	18364113	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Carotid Artery Diseases	47.5%
2	Brain Ischemia	47.5%
3	Cerebrovascular accident	47.5%
4	Intracranial Arterial Diseases	47.5%
5	Basal Ganglia Cerebrovascular Disease	47.1%
6	Brain Infarction	46.8%
7	Vascular Headaches	44.6%
8	Intracranial Embolism and Thrombosis	43.8%
9	Moyamoya Disease	42.3%
10	Infarction, Middle Cerebral Artery	40.4%
11	Infarction, Anterior Cerebral Artery	40.4%
12	Infarction, Posterior Cerebral Artery	40.4%
13	Leukomalacia, Periventricular	39.3%
14	Carotid Artery Thrombosis	38.7%
15	Cerebral Infarction	38.7%
16	Brain Stem Infarctions	38.7%
17	Hypoxia-Ischemia, Brain	37.2%
18	Carotid Artery Injuries	36.6%
19	Dementia, Vascular	36.5%
20	Carotid Stenosis	36.2%
21	Intracranial Aneurysm	36.2%
22	Basal Ganglia Hemorrhage	36.1%
23	Vasculitis, Central Nervous System	35.7%
24	Cerebral Arterial Diseases	35.2%
25	Vertebrobasilar Insufficiency	35.2%
26	Basilar Artery Stenosis	35.2%
27	Vertebral Artery Stenosis	35.2%
28	Intracranial Hemorrhage, Hypertensive	35.2%
29	Transient Cerebral Ischemia	35.2%
30	Lateral Medullary Syndrome	34.7%
31	Subarachnoid Hemorrhage, Traumatic	34%
32	Intracranial Arteriosclerosis	34%
33	Cerebral Atherosclerosis	34%
34	Cerebral Arteriosclerosis	34%
35	Cerebral Thrombosis	32.9%
36	Intracranial Embolism	32.9%
37	Intracranial Thrombosis	32.9%
38	Putaminal Hemorrhage	30.9%
39	Carotid Artery, Internal, Dissection	29.8%
40	Pituitary Apoplexy	29.5%
41	Subclavian Steal Syndrome	29.2%
42	Subarachnoid Hemorrhage	28.2%
43	Cerebral Hemorrhage	28.2%
44	Sinus Thrombosis, Intracranial	27.6%
45	Vertebral Artery Dissection	25.9%
46	Cavernous Sinus Thrombosis	24.9%
47	Sagittal Sinus Thrombosis	24.9%
48	Cerebral Amyloid Angiopathy	23.3%
49	Giant Cell Arteritis	23.3%
50	Temporal Arteritis	23.3%
51	Akinetic Mutism	23.1%
52	Anoxic Encephalopathy	23.1%
53	Basal Ganglia Diseases	23.1%
54	Brain Damage, Chronic	23.1%
55	Cerebellar Diseases	23.1%
56	Encephalitis	23.1%
57	Encephalomalacia	23.1%
58	Epilepsy	23.1%
59	Hydrocephalus	23.1%
60	Congenital Hydrocephalus	23.1%
61	Hypothalamic Diseases	23.1%
62	Thalamic Diseases	23.1%
63	Intracranial Hypertension	23.1%
64	Aura	23.1%
65	Leukoencephalopathy	23.1%
66	Neuroaxonal Dystrophies	23.1%
67	Headache Disorders	23.1%
68	Intracranial Hypotension	23.1%
69	Brain Edema	23.1%
70	Brain Hypoxia	23.1%
71	Aqueductal Stenosis	23.1%
72	Spinal Cord Vascular Diseases	22.7%
73	Subdural Effusion	22.1%
74	Meningoencephalitis	20.8%
75	Lupus Vasculitis, Central Nervous System	20.6%
76	Myocardial Ischemia	20.5%
77	Aneurysm	20.2%
78	Angiomatosis	20.2%
79	Aortic Diseases	20.2%
80	Arterial Occlusive Diseases	20.2%
81	Hyperemia	20.2%
82	Hypotension	20.2%
83	Superior Vena Cava Syndrome	20.2%
84	Telangiectasis	20.2%
85	Vasculitis	20.2%
86	Venous Insufficiency	20.2%
87	Peripheral Vascular Diseases	20.2%
88	Embolism and Thrombosis	20.2%
89	Angiodysplasia	20.2%
90	Capillary Leak Syndrome	20.2%
91	Prehypertension	20.2%
92	Encephalomyelitis	20.2%
93	Posterior Leukoencephalopathy Syndrome	19.8%
94	Posterior reversible encephalopathy syndrome	19.8%
95	Aortic Aneurysm	19.8%
96	Aortitis	19.8%
97	Leriche Syndrome	19.8%
98	Periphlebitis	19.8%
99	Phlebitis	19.8%
100	Thromboangiitis Obliterans	19.8%
101	Brain Hemorrhage, Traumatic	19.4%
102	Parkinsonian Disorders	18.9%
103	Dandy-Walker Syndrome	18.2%
104	Brain Diseases, Metabolic	17.6%
105	Dementia	17.6%
106	Multiple System Atrophy	17.2%
107	Postphlebitic Syndrome	17.2%
108	Retinal Vein Occlusion	17.2%
109	Pneumocephalus	17%
110	Myoclonic Epilepsy	16.9%
111	Epilepsy, Temporal Lobe	16.9%
112	Epilepsy, Rolandic	16.9%
113	Benign Rolandic Epilepsy	16.9%
114	Meningitis	16.9%
115	Movement Disorders	16.9%
116	Pachymeningitis	16.9%
117	Spinal Cord Diseases	16.9%
118	Lewy Body Disease	16.7%
119	Brain Abscess	16.7%
120	Thoracic Outlet Syndrome	16.7%
121	Thrombophlebitis	16.5%
122	Meige Syndrome	16.3%
123	Cerebral Ventriculitis	16.3%
124	MELAS Syndrome	16.2%
125	Epilepsy, Post-Traumatic	16.2%
126	Vascular System Injuries	15.9%
127	Malignant Atrophic Papulosis	15.9%
128	Brain Injuries	15.9%
129	Marchiafava-Bignami Disease	15.8%
130	Brain Neoplasms	15.8%
131	Shwartzman Phenomenon	15.8%
132	Coronary Aneurysm	15.7%
133	Shy-Drager Syndrome	15.6%
134	Hematoma, Subdural	15.4%
135	Hematoma, Epidural, Cranial	15.4%
136	Compartment syndromes	15.4%
137	Hepatic Veno-Occlusive Disease	15.4%
138	Peliosis Hepatis	15.4%
139	Varicocele	15.4%
140	Blue Toe Syndrome	15.3%
141	Cerebral Palsy	15.2%
142	Epilepsies, Partial	15.2%
143	Epilepsy, Generalized	15.2%
144	Pseudotumor Cerebri	15.2%
145	Hypertensive Encephalopathy	15.2%
146	Simple Partial Seizures	15.2%
147	Epilepsy, Reflex	15.2%
148	Headache Disorders, Primary	15.2%
149	Headache Disorders, Secondary	15.2%
150	Medication overuse headache	15.2%
151	Diabetic Angiopathies	15.1%
152	Reperfusion Injury	15.1%
153	Splenic Infarction	15.1%
154	Vascular Neoplasms	15.1%
155	Vasoplegia	15.1%
156	Myocardial Reperfusion Injury	15.1%
157	Hemorrhoids	15%
158	Myelitis	14.9%
159	Aortic Rupture	14.8%
160	Spinal Cord Ischemia	14.8%
161	Hand-Arm Vibration Syndrome	14.7%
162	Aortic Aneurysm, Abdominal	14.6%
163	Aortic Aneurysm, Thoracic	14.6%
164	Brain Death	14.6%
165	Optic Neuropathy, Ischemic	14.3%
166	Anterior Ischemic Optic Neuropathy	14.3%
167	Parkinson Disease	14.2%
168	Ocular Motility Disorders	14.2%
169	Cyclophoria	14.2%
170	Juvenile Myoclonic Epilepsy	14.1%
171	Myoclonic Epilepsies, Progressive	14.1%
172	Cerebellar Neoplasms	13.9%
173	Coronary Thrombosis	13.6%
174	Coronary Artery Disease	13.6%
175	Hematoma, Subdural, Intracranial	13.6%
176	Hematoma, Subdural, Chronic	13.6%
177	Hematoma, Subdural, Acute	13.6%
178	Central Nervous System Infection	13.3%
179	Coronary heart disease	13.2%
180	Myocardial Infarction	13.2%
181	Acute Coronary Syndrome	13.2%
182	Aneurysm, Dissecting	13.2%
183	Arteriosclerosis	13.2%
184	Arteritis	13.2%
185	Embolism	13.2%
186	Erythromelalgia	13.2%
187	Fibromuscular Dysplasia	13.2%
188	Malignant Hypertension	13.2%
189	Raynaud Disease	13.2%
190	Thromboembolism	13.2%
191	Thrombosis	13.2%
192	Essential Hypertension	13.2%
193	Aneurysm, Ruptured	13.2%
194	Iliac Aneurysm	13.2%
195	Pulmonary artery stenosis	13.2%
196	White Coat Hypertension	13.2%
197	Systemic Vasculitis	13.2%
198	Embolus	13.2%
199	Epidural Abscess	13.1%
200	Creutzfeldt-Jakob disease	13.1%
201	Huntington Disease	12.9%
202	Amblyopia	12.7%
203	Neuroleptic Malignant Syndrome	12.7%
204	Myelinolysis, Central Pontine	12.7%
205	Dystonia Musculorum Deformans	12.6%
206	Mesenteric vascular insufficiency	12.2%
207	Arteriovenous fistula	12.2%
208	Pituitary Diseases	12.1%
209	Angioedema	11.9%
210	Colitis, Ischemic	11.9%
211	Heart Diseases	11.8%
212	Polyarteritis Nodosa	11.8%
213	Takayasu Arteritis	11.8%
214	Prion Diseases	11.8%
215	Fabry Disease	11.7%
216	Striatonigral Degeneration	11.7%
217	Hypotension, Orthostatic	11.5%
218	Kluver-Bucy Syndrome	11.5%
219	Post-Exercise Hypotension	11.5%
220	Post-Traumatic Headache	11.4%
221	Tension Headache	11.4%
222	Epilepsy, Complex Partial	11.4%
223	Migraine Disorders	11.4%
224	Abdominal Migraine	11.4%
225	Status Migrainosus	11.4%
226	Cervicogenic Headache	11.4%
227	Sturge-Weber Syndrome	11.3%
228	Presenile dementia	11.2%
229	Senile dementia	11.2%
230	Leukoencephalopathy, Progressive Multifocal	11.1%
231	Anterior Spinal Artery Syndrome	10.9%
232	Progressive supranuclear palsy	10.9%
233	Limbic Encephalitis	10.7%
234	Kounis Syndrome	10.7%
235	Stiff-Person Syndrome	10.7%
236	Cranial nerve diseases	10.6%
237	Demyelinating Diseases	10.6%
238	Demyelination	10.6%
239	Neuromuscular Diseases	10.6%
240	Chronobiology Disorders	10.6%
241	May-Thurner Syndrome	10.5%
242	Angina Pectoris	10.5%
243	Amnesia, Transient Global	10.5%
244	Brain Injuries, Diffuse	10.4%
245	Traumatic Brain Injury	10.4%
246	Cerebellar Ataxia	10.4%
247	Supratentorial Neoplasms	10.4%
248	Pituitary Adenoma	10.2%
249	Pituitary Neoplasms	10.2%
250	Lafora Disease	10.1%
251	Unverricht-Lundborg Syndrome	10.1%
252	Retinal Artery Occlusion	10.1%
253	Retinal Vasculitis	10.1%
254	Hypertensive Retinopathy	10.1%
255	Ataxia Telangiectasia	10.1%
256	MPTP Poisoning	10%
257	Embolism, Amniotic Fluid	10%
258	Persistent Vegetative State	10%
259	Spinal Muscular Atrophy	9.9%
260	Progressive Muscular Atrophy	9.9%
261	Anterior Compartment Syndrome	9.9%
262	Vasculitis, Leukocytoclastic, Cutaneous	9.9%
263	Gastric Antral Vascular Ectasia	9.9%
264	Abdominal Compartment Syndrome	9.9%
265	Arachnoiditis	9.9%
266	Aseptic Meningitis	9.9%
267	Syringomyelia	9.9%
268	Essential Tremor	9.9%
269	Familial Tremor	9.9%
270	Pneumorrhachis	9.9%
271	Writer's Cramp	9.9%
272	Meningitis, Bacterial	9.9%
273	Meningitis, Fungal	9.9%
274	Varicose Ulcer	9.8%
275	Primary Graft Dysfunction	9.8%
276	Spinal Cord Injuries	9.8%
277	Arteriosclerosis Obliterans	9.8%
278	Atherosclerosis	9.8%
279	Air Embolism	9.8%
280	Endarteritis	9.8%
281	Venous Thrombosis	9.8%
282	Deep Vein Thrombosis	9.8%
283	Venous Thromboembolism	9.8%
284	Coronary Occlusion	9.8%
285	Microvascular Angina	9.8%
286	Coronary Stenosis	9.8%
287	ST segment elevation myocardial infarction	9.8%
288	Leukoencephalitis, Acute Hemorrhagic	9.5%
289	Cluster Headache	9.4%
290	Migraine with Aura	9.4%
291	Familial Hemiplegic Migraine	9.4%
292	Chronic Paroxysmal Hemicrania	9.4%
293	SUNCT Syndrome	9.4%
294	Paroxysmal Hemicrania	9.4%
295	Asterixis	9.4%
296	Ballismus	9.4%
297	Poliomyelitis	9.3%
298	Scimitar Syndrome	9.3%
299	Paraneoplastic Cerebellar Degeneration	9.3%
300	Reye Syndrome	9.2%
301	Hepatolenticular Degeneration	9.2%
302	Hepatic Encephalopathy	9.2%
303	Subacute Combined Degeneration	9.1%
304	Encephalomyelitis, Acute Disseminated	9%
305	Lemierre Syndrome	8.9%
306	Pregnancy Complications, Cardiovascular	8.8%
307	Cardiovascular Abnormalities	8.8%
308	Toxoplasmosis, Cerebral	8.8%
309	Empty Sella Syndrome	8.7%
310	Hyperpituitarism	8.7%
311	Hypopituitarism	8.7%
312	Hypophysitis	8.7%
313	Friedreich Ataxia	8.6%
314	Motor Neuron Disease	8.5%
315	CREST Syndrome	8.5%
316	Amyotrophic Lateral Sclerosis	8.5%
317	Ophthalmoplegic Migraine	8.4%
318	Trauma, Nervous System	8.3%
319	Chronic Fatigue Syndrome	8.2%
320	Canavan Disease	8.2%
321	Alexander Disease	8.2%
322	Coronary Restenosis	8.1%
323	Mesenteric Vascular Occlusion	8.1%
324	Mucocutaneous Lymph Node Syndrome	8.1%
325	Diabetic Retinopathy	8%
326	Nervous System Neoplasms	8%
327	Neurologic Manifestations	8%
328	Neurotoxicity Syndromes	8%
329	Livedo Reticularis	7.9%
330	Miller Fisher Syndrome	7.9%
331	Renal hypertension	7.9%
332	Renal Artery Obstruction	7.9%
333	Renal Artery Stenosis	7.9%
334	Spinal Cord Neoplasms	7.9%
335	Hemangioma, Cavernous	7.8%
336	Shock, Cardiogenic	7.8%
337	Scurvy	7.8%
338	Angina, Unstable	7.8%
339	Diffuse Axonal Injury	7.7%
340	Brain Stem Neoplasms	7.7%
341	Brain Diseases, Metabolic, Inborn	7.7%
342	Central Nervous System Fungal Infections	7.6%
343	Conus Medullaris Syndrome	7.6%
344	Intermittent Claudication	7.5%
345	Pulmonary Embolism	7.5%
346	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	7.5%
347	Mitochondrial Encephalomyopathies	7.5%
348	No-Reflow Phenomenon	7.4%
349	Hyperprolactinemia	7.1%
350	Pick Disease of the Brain	7%
351	Myelitis, Transverse	6.9%
352	Tuberculosis, Meningeal	6.9%
353	Restless Legs Syndrome	6.8%
354	Cardiac Tamponade	6.7%
355	Endocarditis	6.7%
356	Cardiac Arrest	6.7%
357	Heart failure	6.7%
358	Pericardial effusion	6.7%
359	Pericarditis	6.7%
360	Pneumopericardium	6.7%
361	Polyradiculoneuropathy	6.7%
362	Cor pulmonale	6.7%
363	Ventricular Outflow Obstruction	6.7%
364	Ventricular Dysfunction	6.7%
365	Cardiomyopathies	6.7%
366	Polyradiculoneuritis	6.7%
367	Pleuropericarditis	6.7%
368	Autonomic Dysreflexia	6.7%
369	Complex Regional Pain Syndromes	6.7%
370	Frontotemporal dementia	6.7%
371	Akathisia, Drug-Induced	6.7%
372	Ischemic contracture	6.6%
373	Aortic Valve Stenosis	6.6%
374	Cardiomyopathy, Dilated	6.6%
375	Pulmonary Valve Stenosis	6.6%
376	Angioedemas, Hereditary	6.6%
377	Tricuspid Atresia	6.6%
378	Arrhythmogenic Right Ventricular Dysplasia	6.6%
379	Cryoglobulinemia	6.6%
380	Wernicke Encephalopathy	6.5%
381	AIDS Dementia Complex	6.5%
382	Auditory Perceptual Disorders	6.5%
383	Diabetic Foot	6.5%
384	Subacute Sclerosing Panencephalitis	6.5%
385	Sleep Wake Disorders	6.5%
386	Brain Contusion	6.5%
387	Angina Pectoris, Variant	6.4%
388	Choroid Plexus Papilloma	6.4%
389	Opsoclonus-Myoclonus Syndrome	6.3%
390	Hepatic Vein Thrombosis	6.2%
391	Budd-Chiari Syndrome	6.2%
392	Adrenoleukodystrophy	6.1%
393	Pulmonary Infarction	6.1%
394	Central Nervous System Bacterial Infections	6.1%
395	Scrapie	6%
396	Central Cord Syndrome	6%
397	Chorea	5.9%
398	Dyskinesia, Drug-Induced	5.9%
399	Kernicterus	5.8%
400	Hypertension, Renovascular	5.8%
401	Hereditary Angioedema Type III	5.8%
402	Hereditary Angioedema Types I and II	5.8%
403	Acromegaly	5.7%
404	Meningitis, Cryptococcal	5.7%
405	Meningitis, Listeria	5.7%
406	Brain Concussion	5.7%
407	Bacterial Endocarditis	5.6%
408	Meningitis, Haemophilus	5.6%
409	Meningitis, Pneumococcal	5.6%
410	Dysautonomia	5.6%
411	Vagus Nerve Disorder	5.6%
412	Glossopharyngeal Neuralgia	5.6%
413	Abducens Nerve Diseases	5.6%
414	Heavy Metal Poisoning, Nervous System	5.6%
415	Neuromuscular Junction Diseases	5.6%
416	Tauopathies	5.6%
417	Trochlear Nerve Diseases	5.6%
418	Peripheral Nervous System Diseases	5.6%
419	Purpura, Hyperglobulinemic	5.6%
420	Peripheral Nerve Injuries	5.4%
421	Myasthenia Gravis	5.4%
422	Hypertrophic Cardiomyopathy	5.3%
423	Hypertrophic obstructive cardiomyopathy	5.3%
424	Heart Block	5.3%
425	Tachycardia	5.3%
426	Tachyarrhythmia	5.3%
427	Aortic coarctation	5.3%
428	Cor Triatriatum	5.3%
429	Coronary Vessel Anomalies	5.3%
430	Patent ductus arteriosus	5.3%
431	Ebstein Anomaly	5.3%
432	Heart Septal Defects	5.3%
433	Tetralogy of Fallot	5.3%
434	Transposition of Great Vessels	5.3%
435	Hypoplastic Left Heart Syndrome	5.3%
436	Torticollis	5.2%
437	Alice in Wonderland Syndrome	5.1%
438	Cardiac Output, High	5.1%
439	Myocardial Stunning	5.1%
440	Low Cardiac Output Syndrome	5.1%
441	Cardiomegaly	5%
442	Postpericardiotomy Syndrome	5%
443	Cardiac Hypertrophy	5%
444	Dural Arteriovenous Fistula	5%
445	West Nile Fever	5%
446	Rheumatic Heart Disease	5%
447	Behcet Syndrome	5%
448	Progressive bulbar palsy	5%
449	Bulbar palsy	5%
450	Waldenstrom Macroglobulinemia	4.9%
451	Multiple Myeloma	4.9%
452	Guillain-Barre Syndrome	4.9%
453	Granulomatosis with polyangiitis	4.9%
454	Supravalvular aortic stenosis	4.9%
455	Lown-Ganong-Levine Syndrome	4.9%
456	Tuberculosis, Central Nervous System	4.8%
457	Sleep Disorders, Circadian Rhythm	4.6%
458	Lambert-Eaton Myasthenic Syndrome	4.6%
459	Causalgia	4.6%
460	Botulism	4.4%
461	Pseudoxanthoma Elasticum	4.4%
462	Central Nervous System Cysts	4.4%
463	Myopathy	4.4%
464	Optic Neuropathy	4.4%
465	Aortic Valve Insufficiency	4.4%
466	Restrictive cardiomyopathy	4.4%
467	Dextrocardia	4.4%
468	Endocardial Fibroelastosis	4.4%
469	Heart Rupture, Post-Infarction	4.4%
470	Long QT Syndrome	4.4%
471	Mitral Valve Insufficiency	4.4%
472	Mitral Valve Stenosis	4.4%
473	Myocarditis	4.4%
474	Pericarditis, Constrictive	4.4%
475	Pulmonary Valve Insufficiency	4.4%
476	Tricuspid Valve Insufficiency	4.4%
477	Tricuspid Valve Stenosis	4.4%
478	Ventricular Dysfunction, Left	4.4%
479	Right Ventricular Dysfunction	4.4%
480	Endomyocardial Fibrosis	4.4%
481	Carditis	4.4%
482	Heart Failure, Systolic	4.4%
483	Heart Failure, Diastolic	4.4%
484	Olfactory Nerve Injuries	4.4%
485	Facial Nerve Diseases	4.3%
486	Craniocerebral Trauma	4.3%
487	Parasomnia	4.3%
488	Dyssomnias	4.3%
489	Galactosemias	4.2%
490	Urea Cycle Disorders, Inborn	4.2%
491	Tyrosinemias	4.2%
492	Refsum Disease	4.2%
493	Nelson Syndrome	4.2%
494	Rheumatoid Vasculitis	4.2%
495	Vestibulocochlear Nerve Diseases	4.2%
496	Decerebrate State	4.2%
497	Hemiparesis	4.2%
498	Hydranencephaly	4.2%
499	Meningism	4.2%
500	Neural Tube Defects	4.2%
501	Paresis	4.2%
502	Seizures	4.2%
503	Sensation Disorders	4.2%
504	Tethered Cord Syndrome	4.2%
505	Central Nervous System Neoplasms	4.2%
506	Complex partial seizures	4.2%
507	Iniencephaly	4.2%
508	Craniorachischisis	4.2%
509	Exencephaly	4.2%
510	Monoparesis	4.2%
511	Septo-Optic Dysplasia	4.2%
512	Cortical Dysplasia	4.2%
513	Neurogenic Inflammation	4.2%
514	Gait Disorders, Neurologic	4.2%
515	Neuromuscular Manifestations	4.2%
516	Malformations of Cortical Development	4.2%
517	Tardive Dyskinesia	4.2%
518	Sick Sinus Syndrome	4.2%
519	Sweating, Gustatory	4.2%
520	Auriculotemporal Syndrome	4.2%
521	Reflex Sympathetic Dystrophy	4.1%
522	Nocturnal Myoclonus Syndrome	4.1%
523	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.1%
524	Prolactinoma	4.1%
525	Growth Hormone-Secreting Pituitary Adenoma	4.1%
526	Multiple Sclerosis	3.9%
527	Neuroaspergillosis	3.9%
528	Neuromyelitis Optica	3.9%
529	Adams-Stokes Syndrome	3.9%
530	Atrioventricular Block	3.9%
531	Bundle-Branch Block	3.9%
532	Atrial Premature Complexes	3.9%
533	Sinoatrial Block	3.9%
534	Tachycardia, Paroxysmal	3.9%
535	Supraventricular tachycardia	3.9%
536	Tachycardia, Ventricular	3.9%
537	Wolff-Parkinson-White Syndrome	3.9%
538	Tachycardia, Reciprocating	3.9%
539	Aortopulmonary Septal Defect	3.9%
540	Double Outlet Right Ventricle	3.9%
541	Endocardial Cushion Defects	3.9%
542	Myocardial bridging	3.9%
543	Aorticopulmonary Septal Defect	3.9%
544	Horner Syndrome	3.9%
545	Homocystinuria	3.8%
546	Leigh Disease	3.8%
547	Facial Nerve Injuries	3.8%
548	Pupil Disorders	3.5%
549	Neurobehavioral Manifestations	3.5%
550	Pseudorabies	3.4%
551	Paraneoplastic Encephalomyelitis	3.4%
552	Uveomeningoencephalitic Syndrome	3.4%
553	Ophthalmoplegia	3.3%
554	Vertigo	3.3%
555	External Ophthalmoplegia	3.3%
556	Alcohol-Induced Disorders, Nervous System	3.3%
557	Noonan Syndrome	3.3%
558	Jet Lag Syndrome	3.3%
559	Sinus Arrhythmia	3.3%
560	Atrial Fibrillation	3.3%
561	Atrial Flutter	3.3%
562	Edema, Cardiac	3.3%
563	Ventricular Fibrillation	3.3%
564	Ventricular Flutter	3.3%
565	Parasystole	3.3%
566	Paroxysmal atrial fibrillation	3.3%
567	Bradycardia	3.3%
568	Diabetic Cardiomyopathies	3.3%
569	Neuritis	3.3%
570	Polyneuritis	3.3%
571	Radiculitis	3.3%
572	Polyneuropathy	3.3%
573	Mononeuritis	3.3%
574	Mononeuropathies	3.3%
575	Brachial Plexus Neuropathies	3.3%
576	Radiculopathy	3.3%
577	Mononeuropathy Multiplex	3.3%
578	Nerve Root Compression	3.3%
579	Cardiomyopathy, Alcoholic	3.3%
580	Ectopia Cordis	3.3%
581	Sudden Cardiac Death	3.3%
582	Left Ventricular Hypertrophy	3.3%
583	Right Ventricular Hypertrophy	3.3%
584	Single umbilical artery	3.3%
585	Subacute Bacterial Endocarditis	3.3%
586	Chagas Cardiomyopathy	3.3%
587	Myasthenia Gravis, Autoimmune, Experimental	3.3%
588	Aortic Valve Prolapse	3.3%
589	Tricuspid Valve Prolapse	3.3%
590	Takotsubo Cardiomyopathy	3.3%
591	Acrodynia	3.3%
592	Brachial Plexus Neuritis	3.3%
593	Neuralgic Amyotrophy	3.3%
594	Carcinoid Heart Disease	3.2%
595	Neurosyphilis	3.2%
596	Menkes Kinky Hair Syndrome	3.2%
597	Romano-Ward Syndrome	3.2%
598	Tachycardia, Atrioventricular Nodal Reentry	3.2%
599	Tachycardia, Ectopic Atrial	3.2%
600	Tachycardia, Ectopic Junctional	3.2%
601	Sinus Tachycardia	3.2%
602	Torsades de Pointes	3.2%
603	Accelerated Idioventricular Rhythm	3.2%
604	Truncus Arteriosus, Persistent	3.2%
605	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.1%
606	Tuberous Sclerosis	3.1%
607	Charcot-Marie-Tooth Disease	3%
608	Marfan Syndrome	3%
609	Toxoplasmosis, Congenital	3%
610	Malaria, Cerebral	3%
611	Neurocysticercosis	2.9%
612	Vocal Cord Paralysis	2.9%
613	Zellweger Syndrome	2.9%
614	Voice Disorders	2.9%
615	Voice Disturbance	2.9%
616	Tarsal Tunnel Syndrome	2.8%
617	Cauda Equina Syndrome	2.8%
618	Glycogen storage disease type II	2.8%
619	Smith-Magenis syndrome	2.8%
620	Coma, Post-Head Injury	2.8%
621	Lyme Neuroborreliosis	2.8%
622	Myotonia Congenita	2.7%
623	Cerebrospinal Fluid Otorrhea	2.7%
624	Cerebrospinal Fluid Rhinorrhea	2.7%
625	Neuritis, Autoimmune, Experimental	2.7%
626	Gait Ataxia	2.7%
627	Dyspnea, Paroxysmal	2.6%
628	Multiple Sclerosis, Chronic Progressive	2.6%
629	Multiple Sclerosis, Relapsing-Remitting	2.6%
630	Myositis	2.5%
631	Optic Atrophy	2.5%
632	Optic Neuritis	2.5%
633	Papilledema	2.5%
634	Strabismus	2.5%
635	Tolosa-Hunt Syndrome	2.5%
636	Isaacs syndrome	2.5%
637	Arsenic Poisoning	2.5%
638	Myotonic Disorders	2.5%
639	Myasthenic Syndromes, Congenital	2.5%
640	Diabetic Neuropathies	2.5%
641	Facial Injuries	2.5%
642	Facial Neuralgia	2.5%
643	Diabetic Amyotrophy	2.5%
644	Diabetic Autonomic Neuropathy	2.5%
645	Sleep Talking	2.5%
646	Manganese Poisoning	2.5%
647	Sleep Disorders, Intrinsic	2.5%
648	Orthostatic intolerance	2.5%
649	Anosmia	2.5%
650	Ataxia	2.5%
651	Athetosis	2.5%
652	Catalepsy	2.5%
653	Dystonia	2.5%
654	Hemiplegia	2.5%
655	Locked-In Syndrome	2.5%
656	Meningeal Neoplasms	2.5%
657	Meningomyelocele	2.5%
658	Muscle Hypertonia	2.5%
659	Muscle hypotonia	2.5%
660	Myoclonus	2.5%
661	Myotonia	2.5%
662	Neuralgia	2.5%
663	Paraplegia	2.5%
664	Pseudobulbar Palsy	2.5%
665	Quadriplegia	2.5%
666	Spasm	2.5%
667	Spastic Paraplegia	2.5%
668	Status Epilepticus	2.5%
669	Taste Disorders	2.5%
670	Tremor	2.5%
671	Spina Bifida	2.5%
672	Monoplegia	2.5%
673	Hypokinesia	2.5%
674	Paraparesis	2.5%
675	Bradykinesia	2.5%
676	Waxy flexibility	2.5%
677	Action Tremor	2.5%
678	Resting Tremor	2.5%
679	Dysosmia	2.5%
680	Quadriparesis	2.5%
681	Mercury Poisoning, Nervous System	2.5%
682	Olfaction Disorders	2.5%
683	Myokymia	2.5%
684	Lead Poisoning, Nervous System	2.5%
685	Vestibular Neuronitis	2.5%
686	Somatosensory Disorders	2.5%
687	Neuropathic pain	2.5%
688	Hyperkinesia	2.5%
689	Intention tremor	2.5%
690	Alcohol Withdrawal Seizures	2.5%
691	Williams Syndrome	2.5%
692	Sinus Arrest, Cardiac	2.4%
693	Waterhouse-Friderichsen Syndrome	2.4%
694	Myotonic Dystrophy	2.4%
695	Reflex, Abnormal	2.4%
696	Hyporeflexia	2.4%
697	Hyperreflexia	2.4%
698	Akathisia	2.3%
699	Restlessness	2.3%
700	Psychomotor Agitation	2.3%
701	Kearns-Sayre syndrome	2.3%
702	Carpal Tunnel Syndrome	2.3%
703	Gaucher Disease	2.3%
704	neurofibroma	2.3%
705	Sciatica	2.3%
706	Sciatic Neuropathy	2.2%
707	Ulnar Neuropathies	2.2%
708	Lesion of Sciatic Nerve	2.2%
709	Ulnar Neuritis	2.2%
710	Radial nerve compression	2.2%
711	Radial Tunnel Syndrome	2.2%
712	Peroneal Neuropathies	2.2%
713	Radial Neuropathy	2.2%
714	Median Neuropathy	2.2%
715	Sciatic Nerve Palsy	2.2%
716	Femoral Neuropathy	2.2%
717	Tibial Neuropathy	2.2%
718	Ulnar Nerve Palsy	2.2%
719	Postural Orthostatic Tachycardia Syndrome	2.2%
720	Radial nerve palsy	2.2%
721	Gait Apraxia	2.1%
722	Tay-Sachs Disease	2.1%
723	Vision Disorders	2.1%
724	Metamorphopsia	2.1%
725	Visual Impairment	2.1%
726	Fibromyalgia	2%
727	Medial Tibial Stress Syndrome	2%
728	Facial Hemiatrophy	2%
729	Melkersson-Rosenthal Syndrome	2%
730	Mitochondrial Myopathies	2%
731	Optic Nerve Glioma	2%
732	Anisocoria	2%
733	Confusion	2%
734	Facial paralysis	2%
735	Lethargy	2%
736	Memory Disorders	2%
737	Muscle Cramp	2%
738	Perceptual Disorders	2%
739	Psychomotor Disorders	2%
740	Tonic Pupil	2%
741	Eosinophilia-Myalgia Syndrome	2%
742	Anhedonia	2%
743	Disorientation	2%
744	Facial Paresis	2%
745	Memory Loss	2%
746	Hemisensory Neglect	2%
747	Dysacusis	2%
748	Sleep Bruxism	2%
749	Anencephaly	2%
750	Meningocele	2%
751	Muscular Atrophy	2%
752	Respiratory Paralysis	2%
753	Encephalocele	2%
754	Tetany	2%
755	Niemann-Pick Disease, Type C	2%
756	Cubital Tunnel Syndrome	1.9%
757	Alstrom Syndrome	1.9%
758	Amyloid Neuropathies, Familial	1.8%
759	Acoustic Neuroma	1.8%
760	Turner Syndrome	1.7%
761	Duane Retraction Syndrome	1.7%
762	Consciousness Disorders	1.7%
763	Mental Retardation	1.7%
764	Muscle Weakness	1.7%
765	Depressed Level of Consciousness	1.7%
766	Mental deficiency	1.7%
767	Intellectual Disability	1.7%
768	Mobius Syndrome	1.7%
769	Bell Palsy	1.7%
770	Catatonia	1.7%
771	Herpes Zoster Oticus	1.7%
772	Familial Periodic Paralysis	1.7%
773	Aphonia	1.6%
774	Sleep Deprivation	1.6%
775	Dysphonia	1.6%
776	Esotropia	1.6%
777	Exotropia	1.6%
778	Sleep Apnea Syndromes	1.6%
779	Polymyositis	1.6%
780	Disorders of Excessive Somnolence	1.6%
781	Sleep Initiation and Maintenance Disorders	1.6%
782	Night Terrors	1.6%
783	Somnambulism	1.6%
784	Trigeminal Nerve Disorder	1.6%
785	Transient Insomnia	1.6%
786	Sleep Paralysis	1.6%
787	Chronic Insomnia	1.6%
788	REM Sleep Behavior Disorder	1.6%
789	Hypersomnia	1.6%
790	Polyradiculopathy	1.6%
791	Dermal Sinus	1.6%
792	Dysgeusia	1.6%
793	Formication	1.6%
794	Hyperalgesia	1.6%
795	Hyperesthesia	1.6%
796	Hypesthesia	1.6%
797	Language Disorders	1.6%
798	Numbness	1.6%
799	Paresthesia	1.6%
800	Paraparesis, Spastic	1.6%
801	Spina Bifida Cystica	1.6%
802	Trismus	1.6%
803	Spina Bifida Occulta	1.6%
804	Epilepsia Partialis Continua	1.6%
805	Hypogeusia	1.6%
806	Meningeal Carcinomatosis	1.6%
807	Brown-Sequard Syndrome	1.6%
808	Lissencephaly	1.6%
809	Polymicrogyria	1.6%
810	Pachygyria	1.6%
811	Schizencephaly	1.6%
812	Lockjaw	1.6%
813	Allodynia	1.6%
814	Lead Poisoning, Nervous System, Childhood	1.6%
815	Lead Poisoning, Nervous System, Adult	1.6%
816	Periventricular Nodular Heterotopia	1.6%
817	Ageusia	1.6%
818	Classical Lissencephalies and Subcortical Band Heterotopias	1.6%
819	Kartagener Syndrome	1.4%
820	Myalgia	1.4%
821	Neuronal Ceroid-Lipofuscinoses	1.4%
822	Alexia	1.4%
823	Dyslexia	1.4%
824	Eye Injuries	1.4%
825	Muscular Dystrophy	1.3%
826	Congenital nystagmus	1.3%
827	Orbital Myositis	1.3%
828	Diplopia	1.3%
829	Muscle Rigidity	1.3%
830	Muscle Spasticity	1.3%
831	Scotoma	1.3%
832	Photophobia	1.3%
833	Cogwheel Rigidity	1.3%
834	Hemifacial Spasm	1.3%
835	Amaurosis	1.3%
836	Blindness	1.3%
837	Nuchal Rigidity	1.3%
838	Pyomyositis	1.3%
839	Agnosia	1.3%
840	Apraxias	1.3%
841	Hallucinations	1.3%
842	Hemianopsia	1.3%
843	Hyperacusis	1.3%
844	Tinnitus	1.3%
845	Visual Agnosia	1.3%
846	Anosognosia	1.3%
847	Wernicke-Korsakoff Syndrome	1.3%
848	Phonophobia	1.3%
849	Hearing Loss	1.3%
850	Sarcopenia	1.3%
851	Optic Atrophy, Hereditary, Leber	1.3%
852	Aicardi's syndrome	1.3%
853	Neurofibrosarcoma	1.3%
854	Hoarseness	1.3%
855	Cockayne Syndrome	1.2%
856	Alcohol Withdrawal Delirium	1.2%
857	Sleep Apnea, Obstructive	1.2%
858	Sleep Apnea, Central	1.2%
859	Narcolepsy	1.2%
860	Trigeminal Neuralgia	1.2%
861	Kleine-Levin Syndrome	1.2%
862	Agraphia	1.2%
863	Anomia	1.2%
864	Cluttering	1.2%
865	Language Development Disorders	1.2%
866	Speech Disorders	1.2%
867	Syncope	1.2%
868	Stupor	1.2%
869	Dysgraphia	1.2%
870	Presyncope	1.2%
871	Dyslalia	1.2%
872	Amnesia	1.1%
873	Delirium	1.1%
874	Dissociative Amnesia	1.1%
875	Color blindness	1.1%
876	Global Amnesia	1.1%
877	Cri-du-Chat Syndrome	1.1%
878	Down Syndrome	1.1%
879	Holoprosencephaly	1.1%
880	Trisomy 21	1.1%
881	POEMS Syndrome	1.1%
882	Meningioma	1.1%
883	Microcephaly	1.1%
884	Macrocephaly	1.1%
885	Hypokalemic periodic paralysis	1.1%
886	Porencephaly	1.1%
887	Cataplexy	1%
888	Aphasia	1%
889	Articulation Disorders	1%
890	Echolalia	1%
891	Stuttering	1%
892	Dysphasia	1%
893	Eye Burns	1%
894	Welander Distal Myopathy	1%
895	Amaurosis Fugax	1%
896	Blindness, Cortical	1%
897	Dyscalculia	1%
898	Rett Syndrome	1%
899	Deafness	1%
900	Hearing Loss, Sudden	1%
901	Gerstmann Syndrome	1%
902	Hearing Loss, Bilateral	1%
903	Hearing Loss, High-Frequency	1%
904	Hearing Loss, Mixed Conductive-Sensorineural	1%
905	Prosopagnosia	1%
906	Apraxia, Ideomotor	1%
907	Charles Bonnet Syndrome	1%
908	Hearing Loss, Unilateral	1%
909	Complete Hearing Loss	1%
910	Alien Hand Syndrome	1%
911	Deaf Mutism	1%
912	Prader-Willi Syndrome	0.9%
913	Phantom pain	0.9%
914	Phantom Limb Pain	0.9%
915	Dysarthria	0.9%
916	Dermatomyositis	0.8%
917	Corneal Scar	0.8%
918	Mutism	0.8%
919	Selective Mutism	0.8%
920	Muscular Dystrophy, Duchenne	0.8%
921	Retrograde amnesia	0.8%
922	Amnesia, Anterograde	0.8%
923	Rubinstein-Taybi Syndrome	0.7%
924	Alexia, Pure	0.7%
925	Fragile X Syndrome	0.7%
926	Corneal Perforation	0.7%
927	Mucopolysaccharidosis II	0.5%

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