MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Twins, Conjoined

(UMLS:C0041428)

Definition:: MONOZYGOTIC TWINS who are joined in utero. They may be well developed and share only a superficial connection, often in the frontal, transverse or sagittal body plane, or they may share a partial duplication of a body structure. Alternatively, there may be a small and incompletely developed twin conjoined to a larger, more fully developed twin.
UMLS ID:: C0041428
MeSH ID:: D014428

Classification:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.085.806

Synonym(s)

Twins, Conjoined

CONJOINED TWINS

Conjoined Twins

Conjoined twins

Conjoined twins, NOS

Siamese twins

Siamese twins, NOS

TWIN SIAMESE

conjoin twin

10.

conjoined twin

11.

conjoined twins

12.

conjoining twins

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Valproic Acid		1893664	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Abnormalities, Drug-Induced	31%
2	Situs Inversus	31%
3	Anencephaly	30.6%
4	Beckwith-Wiedemann Syndrome	23.3%
5	Wolf-Hirschhorn Syndrome	23.3%
6	Eye Abnormalities	22%
7	Cardiovascular Abnormalities	22%
8	Skin Abnormalities	20.9%
9	Lymphatic Abnormalities	20.9%
10	Congenital Microtia	20.9%
11	Congenital diaphragmatic hernia	20.2%
12	Prune Belly Syndrome	20%
13	Waardenburg Syndrome	20%
14	Holoprosencephaly	19%
15	Smith-Magenis syndrome	18.9%
16	Cri-du-Chat Syndrome	18.5%
17	Down Syndrome	18.5%
18	Trisomy 21	18.5%
19	Genetic Diseases, Inborn	18.5%
20	Aicardi's syndrome	16.9%
21	Urogenital Abnormalities	16.4%
22	Ectodermal Dysplasia	15.6%
23	Aplasia Cutis Congenita	15.6%
24	Prader-Willi Syndrome	15.4%
25	CHARGE Syndrome	15.3%
26	Rubinstein-Taybi Syndrome	15.2%
27	Maxillofacial Abnormalities	14.1%
28	Dural Arteriovenous Fistula	14.1%
29	Dextrocardia	13.9%
30	Anophthalmos	13.6%
31	Anus, Imperforate	13.6%
32	Hydranencephaly	13.6%
33	Microphthalmos	13.6%
34	Neural Tube Defects	13.6%
35	Tethered Cord Syndrome	13.6%
36	Iniencephaly	13.6%
37	Craniorachischisis	13.6%
38	Limb Deformities, Congenital	13.6%
39	Exencephaly	13.6%
40	Septo-Optic Dysplasia	13.6%
41	Craniofacial Abnormalities	13.6%
42	Cortical Dysplasia	13.6%
43	Malformations of Cortical Development	13.6%
44	Anorectal Malformations	13.6%
45	Bloom Syndrome	13.3%
46	Nail-Patella Syndrome	12.3%
47	Fetal Diseases	12.2%
48	Xeroderma	12.2%
49	Mobius Syndrome	12.2%
50	Kartagener Syndrome	11.6%
51	Marfan Syndrome	11.4%
52	Microcephaly	10.7%
53	Macrocephaly	10.7%
54	Polycystic Kidney Diseases	10.5%
55	Williams Syndrome	10.5%
56	Abdominal Cramps	10.3%
57	Amniotic Band Syndrome	10.3%
58	Asphyxia Neonatorum	10.3%
59	Blepharophimosis	10.3%
60	Infant, Premature, Diseases	10.3%
61	Laryngostenosis	10.3%
62	Mouth Abnormalities	10.3%
63	Infantile Colic	10.3%
64	Scimitar Syndrome	10.2%
65	Esophageal Atresia	10.2%
66	Intestinal Atresia	10.2%
67	Horseshoe Kidney	10.2%
68	Pectus excavatum	10.2%
69	Klippel-Feil Syndrome	10.1%
70	Gastroschisis	10.1%
71	Synostosis	10.1%
72	Acrodermatitis	10%
73	Lymphangiectasis, Intestinal	10%
74	Gianotti-Crosti Syndrome	10%
75	Abnormalities, Radiation-Induced	10%
76	Amelia	9.9%
77	Arachnodactyly	9.9%
78	Ectopia Cordis	9.9%
79	Ectromelia	9.9%
80	Hemimelia	9.9%
81	Meningomyelocele	9.9%
82	Phocomelia	9.9%
83	Sirenomelia	9.9%
84	Spina Bifida	9.9%
85	Polydactyly	9.9%
86	Brachydactyly	9.9%
87	Plagiocephaly	9.9%
88	Lower Extremity Deformities, Congenital	9.9%
89	Upper Extremity Deformities, Congenital	9.9%
90	Single umbilical artery	9.9%
91	Craniosynostosis	9.8%
92	Syndactyly	9.8%
93	Brachycephaly	9.8%
94	Fragile X Syndrome	9.7%
95	Porencephaly	9.7%
96	Cockayne Syndrome	9.5%
97	Primary Ciliary Dyskinesia	9.4%
98	Classical Lissencephalies and Subcortical Band Heterotopias	9.2%
99	Retinal Dysplasia	9.2%
100	Alstrom Syndrome	9.1%
101	Aniridia	9.1%
102	Epidermolysis Bullosa	8.9%
103	Acrocephalosyndactylia	8.7%
104	Noonan Syndrome	8.6%
105	Cystic Fibrosis	8.5%
106	Smith-Lemli-Opitz Syndrome	8.4%
107	Arthrogryposis	8.3%
108	Choanal Atresia	8.3%
109	Tracheobronchomegaly	8.3%
110	Laryngocele	8.3%
111	Choledochal Cyst	8.2%
112	Hermaphroditism	8.2%
113	Disorders of Sex Development	8.2%
114	Cryptorchidism	8.1%
115	Dermal Sinus	8.1%
116	Spina Bifida Cystica	8.1%
117	Spina Bifida Occulta	8.1%
118	Lissencephaly	8.1%
119	Polymicrogyria	8.1%
120	Pachygyria	8.1%
121	Schizencephaly	8.1%
122	Hypospadias	8.1%
123	Periventricular Nodular Heterotopia	8.1%
124	Central Nervous System Cysts	8.1%
125	Poland Syndrome	8%
126	Dandy-Walker Syndrome	8%
127	POEMS Syndrome	7.9%
128	Jaw Abnormalities	7.9%
129	Ichthyosis, X-Linked	7.9%
130	Turner Syndrome	7.8%
131	Polycystic Kidney, Autosomal Dominant	7.7%
132	Cleft Palate	7.6%
133	Aortic coarctation	7.4%
134	Cor Triatriatum	7.4%
135	Coronary Vessel Anomalies	7.4%
136	Dental Enamel Hypoplasia	7.4%
137	Patent ductus arteriosus	7.4%
138	Ebstein Anomaly	7.4%
139	Heart Septal Defects	7.4%
140	Hypodontia	7.4%
141	Macrostomia	7.4%
142	Meningocele	7.4%
143	Microstomia	7.4%
144	Tetralogy of Fallot	7.4%
145	Transposition of Great Vessels	7.4%
146	Hypoplastic Left Heart Syndrome	7.4%
147	May-Thurner Syndrome	7.4%
148	Encephalocele	7.4%
149	Craniofacial Dysostosis	7.4%
150	Neoplastic Syndromes, Hereditary	7.3%
151	Wolff-Parkinson-White Syndrome	7.3%
152	Klinefelter Syndrome	7.1%
153	Meconium Aspiration Syndrome	6.9%
154	Laryngomalacia	6.9%
155	Anemia, Neonatal	6.8%
156	Multiple Epiphyseal Dysplasia	6.8%
157	Osteochondrodysplasias	6.8%
158	Pelger-Huet Anomaly	6.8%
159	Persistent Fetal Circulation Syndrome	6.8%
160	Werner Syndrome	6.8%
161	Myasthenic Syndromes, Congenital	6.8%
162	Pectus carinatum	6.8%
163	Bladder Exstrophy	6.7%
164	Epispadias	6.7%
165	Umbilical hernia	6.7%
166	Pseudoxanthoma Elasticum	6.7%
167	Familial Mediterranean Fever	6.7%
168	Multicystic Dysplastic Kidney	6.6%
169	Micrognathism	6.6%
170	Pierre Robin Syndrome	6.6%
171	Charcot-Marie-Tooth Disease	6.5%
172	Antley-Bixler Syndrome Phenotype	6.5%
173	Sjogren-Larsson Syndrome	6.4%
174	Kallmann Syndrome	6.3%
175	Hyperkeratosis, Epidermolytic	6.2%
176	Aortopulmonary Septal Defect	6.1%
177	Double Outlet Right Ventricle	6.1%
178	Endocardial Cushion Defects	6.1%
179	Myocardial bridging	6.1%
180	Aorticopulmonary Septal Defect	6.1%
181	Xeroderma Pigmentosum	6%
182	Long QT Syndrome	6%
183	Platybasia	6%
184	Tricuspid Atresia	6%
185	Arrhythmogenic Right Ventricular Dysplasia	6%
186	Gonadal Dysgenesis	5.9%
187	Bronchomalacia	5.9%
188	Adrenogenital Syndrome	5.9%
189	Tracheomalacia	5.9%
190	Ovotesticular Disorders of Sex Development	5.9%
191	Retrognathia	5.8%
192	Truncus Arteriosus, Persistent	5.4%
193	Goldenhar Syndrome	5.4%
194	Zellweger Syndrome	5.4%
195	Dwarfism	5.4%
196	Hyperandrogenism	5.4%
197	Anemia, Sickle Cell	5.3%
198	Thalassemia	5.3%
199	Neonatal Abstinence Syndrome	5.3%
200	Tuberous Sclerosis	5.3%
201	Basal Cell Nevus Syndrome	5.3%
202	Muscular Dystrophy, Duchenne	5.2%
203	Prognathism	5.2%
204	Fetal Growth Retardation	5.1%
205	Muscular Dystrophy	5%
206	Osteogenesis Imperfecta	5%
207	Fetal Hypoxia	5%
208	Congenital nystagmus	5%
209	Fetal Alcohol Spectrum Disorders	5%
210	Toxoplasmosis, Congenital	5%
211	Syphilis, Congenital	5%
212	Mandibulofacial Dysostosis	4.9%
213	Rett Syndrome	4.9%
214	Romano-Ward Syndrome	4.9%
215	Refsum Disease	4.9%
216	Albinism	4.6%
217	Paralysis, Obstetric	4.5%
218	Retinopathy of Prematurity	4.5%
219	Amino Acid Metabolism, Inborn Errors	4.4%
220	Carbohydrate Metabolism, Inborn Errors	4.4%
221	Metal Metabolism, Inborn Errors	4.4%
222	Progeria	4.4%
223	Lysosomal Storage Diseases	4.4%
224	Cytochrome-c Oxidase Deficiency	4.4%
225	Peroxisomal Disorders	4.4%
226	Talipes	4.4%
227	Bronchopulmonary Dysplasia	4.4%
228	Autoimmune Lymphoproliferative Syndrome	4.1%
229	Congenital clubfoot	4.1%
230	Vertical Talus	4.1%
231	Congenital Hyperinsulinism	4.1%
232	Chorioamnionitis	4%
233	Angioedemas, Hereditary	4%
234	Mucopolysaccharidosis II	3.9%
235	Sickle Cell Trait	3.9%
236	Wiskott-Aldrich Syndrome	3.8%
237	Neuronal Ceroid-Lipofuscinoses	3.5%
238	Menkes Kinky Hair Syndrome	3.5%
239	Arteriovenous fistula	3.5%
240	Respiratory Distress Syndrome, Newborn	3.4%
241	Cutis Laxa	3.4%
242	Retinitis Pigmentosa	3.4%
243	Pigmentary retinopathy	3.4%
244	Porokeratosis	3.3%
245	Keratoderma, Palmoplantar	3.3%
246	Chronic granulomatous disease	3.3%
247	Myotonic Dystrophy	3.3%
248	Welander Distal Myopathy	3.3%
249	Alkaptonuria	3.3%
250	Glycogen Storage Disease	3.3%
251	Hypophosphatasia	3.3%
252	Propionic acidemia	3.3%
253	Dihydropyrimidine Dehydrogenase Deficiency	3.3%
254	Cystinosis	3.3%
255	Acute Chest Syndrome	2.8%
256	Amyloid Neuropathies, Familial	2.8%
257	Ophthalmia Neonatorum	2.8%
258	Galactosemias	2.8%
259	Urea Cycle Disorders, Inborn	2.8%
260	Tyrosinemias	2.8%
261	Adrenoleukodystrophy	2.7%
262	Duane Retraction Syndrome	2.7%
263	Hepatolenticular Degeneration	2.7%
264	Porphyrias, Hepatic	2.7%
265	Glycogen Storage Disease Type I	2.7%
266	Glycogen Storage Disease Type V	2.7%
267	Hydrops Fetalis	2.7%
268	Mucopolysaccharidosis III	2.7%
269	Glycogen storage disease type II	2.7%
270	Peutz-Jeghers Syndrome	2.7%
271	Myotonia Congenita	2.6%
272	Thrombasthenia	2.6%
273	Antithrombin III Deficiency	2.6%
274	Protein C Deficiency	2.6%
275	Brain Diseases, Metabolic, Inborn	2.6%
276	Fabry Disease	2.6%
277	Afibrinogenemia	2.6%
278	Dystonia Musculorum Deformans	2.6%
279	Factor VII Deficiency	2.6%
280	Factor X Deficiency	2.6%
281	Factor XII Deficiency	2.6%
282	Hemophilia A	2.6%
283	Leukomalacia, Periventricular	2.6%
284	Activated Protein C Resistance	2.6%
285	Factor II deficiency	2.6%
286	Factor VIII Deficiency	2.6%
287	Factor V deficiency	2.6%
288	Factor XI Deficiency	2.6%
289	Hypoprothrombinemias	2.6%
290	Fanconi Anemia	2.6%
291	Nesidioblastosis	2.6%
292	Lafora Disease	2.6%
293	Unverricht-Lundborg Syndrome	2.6%
294	Anemia, Diamond-Blackfan	2.6%
295	Denys-Drash Syndrome	2.6%
296	Ataxia Telangiectasia	2.5%
297	Hyaline Membrane Disease	2.5%
298	Optic Atrophy, Hereditary, Leber	2.4%
299	Hypolipoproteinemias	2.4%
300	Papillon-Lefevre Disease	2.4%
301	Hyperlipidemia, Familial Combined	2.4%
302	Hyperlipoproteinemia Type III	2.4%
303	Hyperphosphaturia	2.4%
304	Canavan Disease	2.3%
305	Alexander Disease	2.3%
306	Multiple Endocrine Neoplasia	2.3%
307	Homocystinuria	2.2%
308	Congenital Hypothyroidism	2.2%
309	Dermatitis, Atopic	2.2%
310	Leigh Disease	2.2%
311	Gaucher Disease	2.1%
312	Hypoalphalipoproteinemias	2%
313	Carbamoyl-Phosphate Synthase I Deficiency Disease	2%
314	Familial Periodic Paralysis	2%
315	Lactose Intolerance	2%
316	Variegate Porphyria	2%
317	Acute intermittent porphyria	2%
318	Porphyria Cutanea Tarda	2%
319	Hyperhomocysteinemia	2%
320	Tay-Sachs Disease	1.9%
321	Renal Aminoacidurias	1.9%
322	Fanconi Syndrome	1.9%
323	Pseudohypoaldosteronism	1.9%
324	Liddle Syndrome	1.9%
325	Hyperlipoproteinemia Type IV	1.9%
326	Hyperlipoproteinemia Type V	1.9%
327	Kernicterus	1.9%
328	Behcet Syndrome	1.9%
329	Niemann-Pick Disease, Type C	1.8%
330	Gout	1.7%
331	Multiple Endocrine Neoplasia Type 1	1.6%
332	Pseudohypoparathyroidism	1.6%
333	Huntington Disease	1.6%
334	Friedreich Ataxia	1.6%
335	Hypokalemic periodic paralysis	1.6%
336	Renal tubular acidosis	1.6%
337	Cystinuria	1.6%
338	Nephroblastoma	1.5%
339	Arthritis, Gouty	1.4%
340	Adenomatous Polyposis Coli	1.3%
341	Familial Hypophosphatemic Rickets	1.2%
342	Glycosuria, Renal	1.2%
343	MELAS Syndrome	1%

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