MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Mucopolysaccharidosis III

(UMLS:C0026706)

Definition:: Mucopolysaccharidosis characterized by heparitin sulfate in the urine, progressive mental retardation, mild dwarfism, and other skeletal disorders. There are four clinically indistinguishable but biochemically distinct forms, each due to a deficiency of a different enzyme.
UMLS ID:: C0026706
MeSH ID:: D009084

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.202.715.650|C16.320.565.595.600.650

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.550.575.650

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.648.202.715.650|C18.452.648.595.600.650

Synonym(s)

Mucopolysaccharidosis III

HS-mucopolysaccharidosis

Mucopolysaccharidosis Type III

Mucopolysaccharidosis type III

Mucopolysaccharidosis, MPS-III

Mucopolysaccharidosis, type III (MPS III)

OLIGOPHRENIA, POLYDYSTROPHIC

SANFILIPPO SYNDROME

Sanfilippo Syndrome

10.

Sanfilippo disease

11.

Sanfilippo disease (A, B, C, D)

12.

Sanfilippo syndrome

13.

Sanfilippo syndrome (A, B, C, D)

14.

Sanfilippo syndrome, NOS

15.

Sanfilippo syndromes

16.

Sanfilippo's syndrome

17.

heparitinuria

18.

mucopolysaccharide storage disease III

19.

mucopolysaccharidosis (MPS) III (A, B, C, D)

20.

mucopolysaccharidosis type III

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	miglustat	FAERS: 1		US FAERS
2	Lamotrigine		19681008	CTD
3	Olanzapine		19681008	CTD
4	Risperidone		19681008	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Mucopolysaccharidosis II	49.1%
2	Galactosemias	34.1%
3	Amino Acid Metabolism, Inborn Errors	32.3%
4	Metal Metabolism, Inborn Errors	32.3%
5	Progeria	32.3%
6	Peroxisomal Disorders	32.3%
7	Brain Diseases, Metabolic, Inborn	30.6%
8	Glycogen Storage Disease	30.1%
9	Cystinosis	30.1%
10	Glycogen storage disease type II	29.8%
11	Leigh Disease	29.4%
12	Lactose Intolerance	28.9%
13	Smith-Lemli-Opitz Syndrome	28.7%
14	Urea Cycle Disorders, Inborn	27.1%
15	Tyrosinemias	27.1%
16	Homocystinuria	25.2%
17	Hyperphosphaturia	24.8%
18	Menkes Kinky Hair Syndrome	24.4%
19	Pseudohypoparathyroidism	23.3%
20	Cytochrome-c Oxidase Deficiency	23%
21	Adrenoleukodystrophy	22.1%
22	Hepatolenticular Degeneration	21.9%
23	Zellweger Syndrome	21.2%
24	Refsum Disease	21.1%
25	Albinism	20.9%
26	Hyperhomocysteinemia	20.8%
27	Carbamoyl-Phosphate Synthase I Deficiency Disease	20.5%
28	Hypolipoproteinemias	20.4%
29	Ichthyosis, X-Linked	20.1%
30	Glycogen Storage Disease Type I	20%
31	Glycogen Storage Disease Type V	20%
32	Werner Syndrome	19.5%
33	Gaucher Disease	19.3%
34	Alkaptonuria	19.2%
35	Hypophosphatasia	19.2%
36	Propionic acidemia	19.2%
37	Dihydropyrimidine Dehydrogenase Deficiency	19.2%
38	Hyperlipidemia, Familial Combined	19.2%
39	Fabry Disease	18.8%
40	Hyperlipoproteinemia Type III	18.5%
41	Amyloid Neuropathies, Familial	18.5%
42	Hyperlipoproteinemia Type IV	18.1%
43	Hyperlipoproteinemia Type V	18.1%
44	Wasting Syndrome	16.9%
45	Neuronal Ceroid-Lipofuscinoses	16.7%
46	Renal tubular acidosis	16.3%
47	Carbohydrate Metabolism, Inborn Errors	16.1%
48	Lysosomal Storage Diseases	16.1%
49	Sjogren-Larsson Syndrome	15.4%
50	Familial Periodic Paralysis	15.2%
51	Familial Hypophosphatemic Rickets	15.1%
52	Renal Aminoacidurias	14.9%
53	Fanconi Syndrome	14.9%
54	Pseudohypoaldosteronism	14.9%
55	Liddle Syndrome	14.9%
56	Niemann-Pick Disease, Type C	14.9%
57	Cockayne Syndrome	14.8%
58	Osteogenesis Imperfecta	14.6%
59	Acid-Base Imbalance	14.6%
60	Calcium Metabolism Disorders	14.6%
61	Iron Metabolism Disorders	14.6%
62	Phosphorus Metabolism Disorders	14.6%
63	Water-Electrolyte Imbalance	14.6%
64	Lipid Metabolism Disorders	14.6%
65	Mitochondrial Diseases	14.6%
66	Glucose Metabolism Disorders	14.6%
67	Antley-Bixler Syndrome Phenotype	14.4%
68	Tay-Sachs Disease	14.3%
69	Hypercalcemia	13.8%
70	Hypocalcemia	13.8%
71	Milk-Alkali Syndrome	13.8%
72	Marfan Syndrome	13.7%
73	Gout	13.7%
74	Glycosuria, Renal	13.6%
75	Hypoalphalipoproteinemias	13.5%
76	Cutis Laxa	13.5%
77	Cystic Fibrosis	13.4%
78	Lipodystrophy	13.4%
79	CHARGE Syndrome	13.1%
80	MELAS Syndrome	13%
81	Neoplastic Syndromes, Hereditary	12.9%
82	Nail-Patella Syndrome	12.8%
83	Osteopenia	12.7%
84	Aicardi's syndrome	12.6%
85	Brain Diseases, Metabolic	12.6%
86	Multiple Epiphyseal Dysplasia	12.6%
87	Osteochondrodysplasias	12.6%
88	Pelger-Huet Anomaly	12.6%
89	Myasthenic Syndromes, Congenital	12.6%
90	Canavan Disease	12.1%
91	Alexander Disease	12.1%
92	Porphyrias, Hepatic	12%
93	Xeroderma Pigmentosum	11.9%
94	Ataxia Telangiectasia	11.5%
95	Rickets	11.3%
96	Dwarfism	11.3%
97	Scleromyxedema	11.2%
98	Pseudoxanthoma Elasticum	11.2%
99	Muscular Dystrophy	11%
100	Anemia, Sickle Cell	10.8%
101	Thalassemia	10.8%
102	Muscular Dystrophy, Duchenne	10.7%
103	Fanconi Anemia	10.7%
104	Angioedemas, Hereditary	10.3%
105	Beckwith-Wiedemann Syndrome	10.1%
106	Wolf-Hirschhorn Syndrome	10.1%
107	Ectodermal Dysplasia	10.1%
108	Aplasia Cutis Congenita	10.1%
109	Hypokalemic periodic paralysis	10%
110	Autoimmune Lymphoproliferative Syndrome	9.9%
111	Cystinuria	9.9%
112	Congenital Hyperinsulinism	9.8%
113	Myxoid cyst	9.8%
114	Necrobiosis Lipoidica Diabeticorum	9.7%
115	Myxedema	9.7%
116	Fragile X Syndrome	9.6%
117	Epidermolysis Bullosa	9.4%
118	Deformity	9.4%
119	Nutrition Disorders	9.4%
120	Lupus Erythematosus, Cutaneous	9.4%
121	Panniculitis	9.4%
122	Systemic Scleroderma	9.4%
123	Morphea	9.4%
124	Kartagener Syndrome	9.3%
125	Lipomatosis	9.3%
126	Bloom Syndrome	9.2%
127	Smith-Magenis syndrome	9.1%
128	Prader-Willi Syndrome	9.1%
129	Alstrom Syndrome	9%
130	Cri-du-Chat Syndrome	9%
131	Down Syndrome	9%
132	Trisomy 21	9%
133	Arthritis, Gouty	9%
134	Mucopolysaccharidosis III	8.9%
135	Optic Atrophy, Hereditary, Leber	8.9%
136	Wiskott-Aldrich Syndrome	8.8%
137	Kallmann Syndrome	8.5%
138	Porokeratosis	8.5%
139	Keratoderma, Palmoplantar	8.5%
140	Holoprosencephaly	8.4%
141	Fetal Diseases	8.1%
142	Collagen Diseases	8.1%
143	Mixed Connective Tissue Disease	8.1%
144	Myotonic Dystrophy	8.1%
145	Acidosis	8%
146	Alkalosis	8%
147	Amyloidosis	8%
148	Calcinosis	8%
149	Hyperglycemia	8%
150	Hyperinsulinism	8%
151	Hyperkalemia	8%
152	Hypernatremia	8%
153	Hypoglycemia	8%
154	Hypokalemia	8%
155	Hyponatremia	8%
156	Familial Mediterranean Fever	8%
157	Xanthomatosis	8%
158	Hypophosphatemia	8%
159	Metabolic acidosis	8%
160	Dyslipidemias	8%
161	Iron Overload	8%
162	Xanthoma	8%
163	Dermatitis, Atopic	7.8%
164	Mitochondrial Encephalomyopathies	7.7%
165	Friedreich Ataxia	7.7%
166	Tuberous Sclerosis	7.6%
167	Rubinstein-Taybi Syndrome	7.6%
168	Xeroderma	7.3%
169	Dermatomyositis	7.3%
170	Rett Syndrome	7.2%
171	Cartilage Diseases	7.2%
172	Rheumatism	7.2%
173	Chondromalacia	7.2%
174	Panniculitis, Lupus Erythematosus	7.2%
175	Polycystic Kidney Diseases	7.2%
176	Williams Syndrome	7.2%
177	Variegate Porphyria	7.1%
178	Acute intermittent porphyria	7.1%
179	Porphyria Cutanea Tarda	7.1%
180	Diabetes Mellitus	7.1%
181	Lupus Erythematosus, Systemic	7%
182	Overlap syndrome	7%
183	Dehydration	7%
184	Water Intoxication	7%
185	Achlorhydria	6.9%
186	Osteoporosis	6.9%
187	Bone Demineralization, Pathologic	6.9%
188	Post-Traumatic Osteoporosis	6.9%
189	Celiac Disease	6.9%
190	Sprue, Tropical	6.9%
191	Steatorrhea	6.9%
192	Sprue	6.9%
193	Osteomalacia	6.8%
194	Primary Ciliary Dyskinesia	6.8%
195	Retinal Dysplasia	6.6%
196	Aniridia	6.6%
197	Skin Abnormalities	6.6%
198	HIV Wasting Syndrome	6.5%
199	Sickle Cell Trait	6.4%
200	Noonan Syndrome	6.2%
201	Mitochondrial Myopathies	6.1%
202	Retinitis Pigmentosa	6.1%
203	Myelinolysis, Central Pontine	6.1%
204	Pigmentary retinopathy	6.1%
205	Dupuytren Contracture	6.1%
206	Nesidioblastosis	6.1%
207	Glycosuria	6%
208	Chronic granulomatous disease	6%
209	Reye Syndrome	6%
210	Hepatic Encephalopathy	6%
211	Diabetic Ketoacidosis	6%
212	Welander Distal Myopathy	6%
213	Meconium Aspiration Syndrome	6%
214	Kernicterus	6%
215	Behcet Syndrome	5.9%
216	Peutz-Jeghers Syndrome	5.9%
217	HIV-Associated Lipodystrophy Syndrome	5.8%
218	Lupus Erythematosus, Discoid	5.5%
219	Scleroderma, Limited	5.5%
220	Hyperkeratosis, Epidermolytic	5.5%
221	Adiposis Dolorosa	5.5%
222	Duane Retraction Syndrome	5.5%
223	Cellulitis	5.4%
224	Myotonia Congenita	5.4%
225	Thrombasthenia	5.4%
226	Antithrombin III Deficiency	5.4%
227	Protein C Deficiency	5.4%
228	Afibrinogenemia	5.4%
229	Dystonia Musculorum Deformans	5.4%
230	Factor VII Deficiency	5.4%
231	Factor X Deficiency	5.4%
232	Factor XII Deficiency	5.4%
233	Hemophilia A	5.4%
234	Activated Protein C Resistance	5.4%
235	Factor II deficiency	5.4%
236	Factor VIII Deficiency	5.4%
237	Factor V deficiency	5.4%
238	Factor XI Deficiency	5.4%
239	Hypoprothrombinemias	5.4%
240	Lafora Disease	5.3%
241	Unverricht-Lundborg Syndrome	5.3%
242	Anemia, Diamond-Blackfan	5.3%
243	Acute Chest Syndrome	5.3%
244	Wernicke Encephalopathy	5.2%
245	Papillon-Lefevre Disease	5.2%
246	Renal Osteodystrophy	5.1%
247	Renal rickets	5.1%
248	Mobius Syndrome	5.1%
249	Multiple Endocrine Neoplasia	5%
250	CREST Syndrome	5%
251	Congenital Hypothyroidism	4.9%
252	Abdominal Cramps	4.9%
253	Abnormalities, Drug-Induced	4.9%
254	Amniotic Band Syndrome	4.9%
255	Asphyxia Neonatorum	4.9%
256	Child Nutrition Disorders	4.9%
257	Hypervitaminosis A	4.9%
258	Infant Nutrition Disorders	4.9%
259	Infant, Premature, Diseases	4.9%
260	Situs Inversus	4.9%
261	Malnutrition	4.9%
262	Infantile Colic	4.9%
263	Acidosis, Lactic	4.8%
264	Calciphylaxis	4.8%
265	Hemosiderosis	4.8%
266	Ketosis	4.8%
267	Ketonuria	4.8%
268	Ketoacidosis	4.8%
269	Ketonemia	4.8%
270	Vascular calcification	4.8%
271	Laryngomalacia	4.7%
272	Basal Cell Nevus Syndrome	4.6%
273	Pectus carinatum	4.6%
274	Kearns-Sayre syndrome	4.5%
275	Acrodermatitis	4.5%
276	Gianotti-Crosti Syndrome	4.5%
277	Erythema Induratum	4.4%
278	Eye Abnormalities	4.3%
279	Cardiovascular Abnormalities	4.3%
280	Polycystic Kidney, Autosomal Dominant	4.3%
281	Lymphatic Abnormalities	4.2%
282	Congenital Microtia	4.2%
283	Anemia, Neonatal	4.2%
284	Mesenteric Panniculitis	4.2%
285	Panniculitis, Peritoneal	4.2%
286	Persistent Fetal Circulation Syndrome	4.2%
287	Tietze's Syndrome	4.2%
288	Orbital Cellulitis	4.2%
289	Congenital diaphragmatic hernia	4.2%
290	Umbilical hernia	4.2%
291	Acidosis, Respiratory	4.1%
292	Alkalosis, Respiratory	4.1%
293	Insulin Resistance	4.1%
294	Osteoporosis, Postmenopausal	4.1%
295	Huntington Disease	4%
296	Classical Lissencephalies and Subcortical Band Heterotopias	4%
297	Charcot-Marie-Tooth Disease	3.9%
298	Urogenital Abnormalities	3.8%
299	Nephroblastoma	3.7%
300	Neonatal Abstinence Syndrome	3.7%
301	Osteochondritis	3.7%
302	Polymyalgia Rheumatica	3.7%
303	Gestational Diabetes	3.7%
304	Latent Autoimmune Diabetes in Adults	3.7%
305	Fetal Growth Retardation	3.7%
306	Diabetes Mellitus, Experimental	3.7%
307	Fetal Hypoxia	3.7%
308	Congenital nystagmus	3.7%
309	Fetal Alcohol Spectrum Disorders	3.7%
310	Pyoderma Gangrenosum	3.6%
311	Toxoplasmosis, Congenital	3.6%
312	Syphilis, Congenital	3.6%
313	Granuloma Annulare	3.6%
314	Keloid	3.6%
315	Nephrocalcinosis	3.6%
316	Tetany	3.6%
317	Cerebral Amyloid Angiopathy	3.6%
318	Adenomatous Polyposis Coli	3.4%
319	Rheumatoid Arthritis	3.3%
320	Juvenile arthritis	3.3%
321	Chorioamnionitis	3.3%
322	Primary amyloidosis	3.2%
323	Anencephaly	3.2%
324	Bronchomalacia	3.2%
325	Tracheomalacia	3.2%
326	Lupus Nephritis	3.2%
327	Hypercholesterolemia	3.2%
328	Hyperlipoproteinemias	3.2%
329	Hypertriglyceridemia	3.2%
330	Hydrops Fetalis	3%
331	Abnormalities, Radiation-Induced	2.9%
332	Amyotrophic Lateral Sclerosis	2.9%
333	Multiple Endocrine Neoplasia Type 1	2.9%
334	Maxillofacial Abnormalities	2.9%
335	Dural Arteriovenous Fistula	2.9%
336	Dextrocardia	2.9%
337	Acne Vulgaris	2.8%
338	Contact Dermatitis	2.8%
339	Eczema	2.8%
340	Erythema Multiforme	2.8%
341	Intertrigo	2.8%
342	Neurodermatitis	2.8%
343	Rhinophyma	2.8%
344	Perioral Dermatitis	2.8%
345	Acne	2.8%
346	Breast Diseases	2.7%
347	Dermatitis	2.7%
348	Exanthema	2.7%
349	Facial Dermatoses	2.7%
350	Hair Diseases	2.7%
351	Hand Dermatoses	2.7%
352	keratoacanthoma	2.7%
353	Keratosis	2.7%
354	Nail Diseases	2.7%
355	Photosensitivity Disorders	2.7%
356	Prurigo	2.7%
357	Pyoderma	2.7%
358	Rosacea	2.7%
359	Sebaceous Gland Diseases	2.7%
360	Skin Diseases, Vesiculobullous	2.7%
361	Skin Ulcer	2.7%
362	Sweat Gland Diseases	2.7%
363	Skin Diseases, Papulosquamous	2.7%
364	Skin Diseases, Vascular	2.7%
365	Acneiform Eruptions	2.7%
366	Ocular Rosacea	2.7%
367	Subcorneal pustular dermatosis	2.7%
368	Erythematotelangiectatic Rosacea	2.7%
369	Papulopustular Rosacea	2.7%
370	Chronic Actinic Dermatitis	2.7%
371	Deficiency Diseases	2.7%
372	Prune Belly Syndrome	2.7%
373	Starvation	2.7%
374	Turner Syndrome	2.7%
375	Twins, Conjoined	2.7%
376	Refeeding Syndrome	2.7%
377	Waardenburg Syndrome	2.7%
378	Klinefelter Syndrome	2.7%
379	Ophthalmia Neonatorum	2.6%
380	Dermatitis Herpetiformis	2.4%
381	Sebaceous Gland Neoplasms	2.4%
382	Rheumatoid Nodule	2.4%
383	Scimitar Syndrome	2.4%
384	Dermatitis, Phototoxic	2.4%
385	Pityriasis Lichenoides et Varioliformis Acuta	2.4%
386	Pityriasis Lichenoides	2.4%
387	Phototoxicity	2.4%
388	Foot Diseases	2.4%
389	Skin Diseases, Infectious	2.3%
390	Skin Neoplasms	2.3%
391	Pigmentation Disorders	2.3%
392	Anophthalmos	2.3%
393	Anus, Imperforate	2.3%
394	Hydranencephaly	2.3%
395	Microphthalmos	2.3%
396	Neural Tube Defects	2.3%
397	Paralysis, Obstetric	2.3%
398	Pruritus	2.3%
399	Retinopathy of Prematurity	2.3%
400	Erythema	2.3%
401	Tethered Cord Syndrome	2.3%
402	Iniencephaly	2.3%
403	Craniorachischisis	2.3%
404	Limb Deformities, Congenital	2.3%
405	Necrolytic Migratory Erythema	2.3%
406	Exencephaly	2.3%
407	Septo-Optic Dysplasia	2.3%
408	Craniofacial Abnormalities	2.3%
409	Cutaneous Fistula	2.3%
410	Cortical Dysplasia	2.3%
411	Nephrogenic Fibrosing Dermopathy	2.3%
412	Malformations of Cortical Development	2.3%
413	Anorectal Malformations	2.3%
414	Nephrogenic Systemic Fibrosis	2.3%
415	Bronchopulmonary Dysplasia	2.3%
416	Foot Ulcer	2.3%
417	Felty Syndrome	2.2%
418	Dermatitis, Photoallergic	2.1%
419	Frontotemporal dementia	2.1%
420	Denys-Drash Syndrome	2.1%
421	Blepharophimosis	2.1%
422	Laryngostenosis	2.1%
423	Mouth Abnormalities	2.1%
424	Respiratory Distress Syndrome, Newborn	2.1%
425	Esophageal Atresia	2%
426	Intestinal Atresia	2%
427	Horseshoe Kidney	2%
428	Pectus excavatum	2%
429	Klippel-Feil Syndrome	2%
430	Mastocytosis	2%
431	Gastroschisis	2%
432	Synostosis	2%
433	Lymphangiectasis, Intestinal	2%
434	Urticaria Pigmentosa	2%
435	Rheumatoid Vasculitis	1.9%
436	Craniosynostosis	1.9%
437	Syndactyly	1.9%
438	Brachycephaly	1.9%
439	Arthrogryposis	1.8%
440	Choanal Atresia	1.8%
441	Tracheobronchomegaly	1.8%
442	Laryngocele	1.8%
443	Choledochal Cyst	1.8%
444	Hermaphroditism	1.8%
445	Disorders of Sex Development	1.8%
446	Dermatitis, Irritant	1.8%
447	Acne Conglobata	1.8%
448	Cryptorchidism	1.8%
449	Hypospadias	1.8%
450	Lupus Vasculitis, Central Nervous System	1.8%
451	Erythema Infectiosum	1.8%
452	Central Nervous System Cysts	1.8%
453	Dandy-Walker Syndrome	1.8%
454	Exanthema Subitum	1.8%
455	Leukomalacia, Periventricular	1.8%
456	POEMS Syndrome	1.8%
457	Erythema Nodosum	1.8%
458	Microcephaly	1.8%
459	Macrocephaly	1.8%
460	Obesity	1.8%
461	Sicca Syndrome	1.8%
462	Sjogren's Syndrome	1.8%
463	Toxic Epidermal Necrolysis	1.8%
464	Stevens-Johnson Syndrome	1.8%
465	Acrocephalosyndactylia	1.7%
466	Dermatitis, Occupational	1.6%
467	Bladder Exstrophy	1.6%
468	Epispadias	1.6%
469	Multicystic Dysplastic Kidney	1.6%
470	Ecthyma	1.6%
471	Dermatitis, Allergic Contact	1.6%
472	Anhidrosis	1.6%
473	Cholesteatoma	1.6%
474	Pressure Ulcer	1.6%
475	Folliculitis	1.6%
476	Foot Dermatoses	1.6%
477	Gynecomastia	1.6%
478	Hypertrichosis	1.6%
479	Hypohidrosis	1.6%
480	Hypotrichosis	1.6%
481	Leg Ulcer	1.6%
482	Miliaria	1.6%
483	Parakeratosis	1.6%
484	Parapsoriasis	1.6%
485	Pityriasis	1.6%
486	Psoriasis	1.6%
487	Sweet Syndrome	1.6%
488	Hidradenitis	1.6%
489	Onycholysis	1.6%
490	Miliaria Rubra	1.6%
491	Hyperpigmentation	1.6%
492	Lichenoid Eruptions	1.6%
493	Chloracne	1.6%
494	Tinea Capitis	1.6%
495	Onychomycosis	1.6%
496	Kwashiorkor	1.6%
497	Magnesium Deficiency	1.6%
498	Potassium Deficiency	1.6%
499	Protein Deficiency	1.6%
500	Avitaminosis	1.6%
501	Cleft Palate	1.5%
502	Jaw Abnormalities	1.5%
503	Porencephaly	1.4%
504	Acantholysis	1.4%
505	Breast Cyst	1.4%
506	Actinic keratosis	1.4%
507	Pemphigoid, Benign Mucous Membrane	1.4%
508	Pemphigus	1.4%
509	Piedra	1.4%
510	Sunburn	1.4%
511	Argyria	1.4%
512	Hirsutism	1.4%
513	Lactation Disorder	1.4%
514	Mastitis	1.4%
515	Urticaria	1.4%
516	Amelia	1.4%
517	Arachnodactyly	1.4%
518	Ectopia Cordis	1.4%
519	Ectromelia	1.4%
520	Hemimelia	1.4%
521	Meningomyelocele	1.4%
522	Phocomelia	1.4%
523	Pruritus Vulvae	1.4%
524	Sirenomelia	1.4%
525	Spina Bifida	1.4%
526	Polydactyly	1.4%
527	Brachydactyly	1.4%
528	Plagiocephaly	1.4%
529	Lower Extremity Deformities, Congenital	1.4%
530	Upper Extremity Deformities, Congenital	1.4%
531	Single umbilical artery	1.4%
532	Mastocytoma	1.4%
533	Pruritus Ani	1.4%
534	Diaper Rash	1.4%
535	Erythema Chronicum Migrans	1.3%
536	Hidradenitis Suppurativa	1.3%
537	Poland Syndrome	1.3%
538	Dermatomycoses	1.2%
539	Mucocutaneous Lymph Node Syndrome	1.2%
540	Skin Diseases, Bacterial	1.2%
541	Drug Eruptions	1.2%
542	Livedo Reticularis	1.2%
543	Malignant Atrophic Papulosis	1.2%
544	Aortic coarctation	1.2%
545	Cor Triatriatum	1.2%
546	Coronary Vessel Anomalies	1.2%
547	Dental Enamel Hypoplasia	1.2%
548	Patent ductus arteriosus	1.2%
549	Ebstein Anomaly	1.2%
550	Heart Septal Defects	1.2%
551	Hyaline Membrane Disease	1.2%
552	Hypodontia	1.2%
553	Macrostomia	1.2%
554	Meningocele	1.2%
555	Microstomia	1.2%
556	Tetralogy of Fallot	1.2%
557	Transposition of Great Vessels	1.2%
558	Hypoplastic Left Heart Syndrome	1.2%
559	May-Thurner Syndrome	1.2%
560	Encephalocele	1.2%
561	Craniofacial Dysostosis	1.2%
562	Polyarteritis Nodosa	1.2%
563	Takayasu Arteritis	1.2%
564	Wolff-Parkinson-White Syndrome	1.2%
565	Obesity, Abdominal	1.2%
566	Tinea Pedis	1.1%
567	Long QT Syndrome	1.1%
568	Platybasia	1.1%
569	Tricuspid Atresia	1.1%
570	Arrhythmogenic Right Ventricular Dysplasia	1.1%
571	Gonadal Dysgenesis	1.1%
572	Adrenogenital Syndrome	1.1%
573	Ovotesticular Disorders of Sex Development	1.1%
574	Mycetoma	1.1%
575	Lichen Planus	1.1%
576	Melanosis	1.1%
577	Chloasma	1.1%
578	Pityriasis Rosea	1.1%
579	Pityriasis Rubra Pilaris	1.1%
580	Vitiligo	1.1%
581	Lichen Nitidus	1.1%
582	Ascorbic Acid Deficiency	1.1%
583	Vitamin A Deficiency	1.1%
584	Vitamin D Deficiency	1.1%
585	Vitamin E Deficiency	1.1%
586	Marasmus	1.1%
587	Pediatric Obesity	1.1%
588	Micrognathism	1%
589	Pierre Robin Syndrome	1%
590	Hyperandrogenism	1%
591	Retrognathia	0.9%
592	Alopecia	0.9%
593	Sweating, Gustatory	0.9%
594	Androgenetic Alopecia	0.9%
595	Auriculotemporal Syndrome	0.9%
596	Lice Infestations	0.9%
597	Varicose Ulcer	0.9%
598	Breast Neoplasms, Male	0.9%
599	Triple Negative Breast Neoplasms	0.9%
600	Galactorrhea	0.9%
601	Dermal Sinus	0.9%
602	Spina Bifida Cystica	0.9%
603	Spina Bifida Occulta	0.9%
604	Lissencephaly	0.9%
605	Polymicrogyria	0.9%
606	Pachygyria	0.9%
607	Schizencephaly	0.9%
608	Periventricular Nodular Heterotopia	0.9%
609	Prognathism	0.9%
610	Larva Migrans	0.8%
611	Leishmaniasis	0.8%
612	Molluscum Contagiosum	0.8%
613	Angioedema	0.8%
614	Onchocerciasis	0.8%
615	Giant Cell Arteritis	0.8%
616	Temporal Arteritis	0.8%
617	Vitamin K Deficiency	0.8%
618	Chromoblastomycosis	0.8%
619	Dermatophytosis	0.8%
620	Sporotrichosis	0.8%
621	Tinea	0.8%
622	Tinea Versicolor	0.8%
623	Trichophytosis	0.8%
624	Hyalohyphomycosis	0.8%
625	Acute Generalized Exanthematous Pustulosis	0.8%
626	Aortopulmonary Septal Defect	0.8%
627	Double Outlet Right Ventricle	0.8%
628	Endocardial Cushion Defects	0.8%
629	Myocardial bridging	0.8%
630	Aorticopulmonary Septal Defect	0.8%
631	Acanthosis Nigricans	0.8%
632	Alopecia Areata	0.8%
633	Lentigo	0.8%
634	Folic Acid Deficiency	0.8%
635	Pellagra	0.8%
636	Thiamine Deficiency	0.8%
637	Vitamin B 12 Deficiency	0.8%
638	Vitamin B 6 Deficiency	0.8%
639	Pyridoxine Deficiency	0.8%
640	Warts	0.7%
641	Candidiasis, Chronic Mucocutaneous	0.7%
642	Cutaneous Candidiasis	0.7%
643	Erysipelas	0.7%
644	Serum Sickness	0.7%
645	Staphylococcal Skin Infections	0.7%
646	Erythrasma	0.7%
647	Carcinoma, Lobular	0.7%
648	Mandibulofacial Dysostosis	0.7%
649	Arthritis, Psoriatic	0.7%
650	Romano-Ward Syndrome	0.7%
651	Lichen Planus, Oral	0.7%
652	Beriberi	0.7%
653	Leishmaniasis, Cutaneous	0.6%
654	Eczema Herpeticum	0.6%
655	Scurvy	0.6%
656	Fusariosis	0.6%
657	Truncus Arteriosus, Persistent	0.6%
658	Goldenhar Syndrome	0.6%
659	Blastomycosis	0.6%
660	Arteriovenous fistula	0.6%
661	Anemia, Pernicious	0.6%
662	Rhinoscleroma	0.5%
663	Epidermodysplasia Verruciformis	0.5%
664	Herpes Labialis	0.5%
665	Talipes	0.5%
666	Diabetic Foot	0.5%
667	Staphylococcal Scalded Skin Syndrome	0.5%
668	Hereditary Angioedema Type III	0.5%
669	Hereditary Angioedema Types I and II	0.5%
670	Condylomata Acuminata	0.5%
671	Furunculosis	0.5%
672	furuncle	0.5%
673	Impetigo	0.5%
674	Congenital clubfoot	0.4%
675	Vertical Talus	0.4%
676	carbuncle	0.4%
677	Subacute Combined Degeneration	0.4%

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