MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acromegaly

(UMLS:C0001206)

Definition:: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
UMLS ID:: C0001206
MeSH ID:: D000172

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.132.082

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.617.738.250.100

Classification 3:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.700.355.179

Synonym(s)

Acromegaly

ACROMEGALY

Acromegalia

Anterior pituitary adenoma syndrome

Eosinophilic adenoma syndrome

Growth hormone hypersecretion syndrome

Marie disease

Marie's syndrome

STH hypersecretion syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Octreotide	FAERS: 9 Canada Vigilance: 2		Canada Vigilance US FAERS
2	Latanoprost	FAERS: 6		US FAERS
3	Norgestrel	FAERS: 6		OFFSIDES US FAERS
4	Cabergoline	FAERS: 5		US FAERS
5	Citalopram	FAERS: 5		US FAERS
6	lanreotide	FAERS: 5		US FAERS
7	Risperidone	FAERS: 4		US FAERS
8	Bromocriptine	FAERS: 2		US FAERS
9	Bromocriptine	FAERS: 2	View details 63831 79115 335755 3226523 7293648	CTD SIDER US FAERS
10	Octreotide	FAERS: 2	View details 1518433 1561523 1563079 1628089 1631261 1683947 1752152 1769469 2042694 2111918 2229321 2319110 2404445 2508821 2513036 3059976 7593435 7711880 7954762 8212985 8314514 8421099 8432484 8707128 10494874 10601961 11148435 11398310 11552916 11788010 16449332 16670150 18463367	CTD OFFSIDES US FAERS
11	Carbamazepine	FAERS: 1		US FAERS
12	Finasteride	FAERS: 1		US FAERS
13	Insulin Glargine	FAERS: 1		US FAERS
14	Omeprazole	FAERS: 1		US FAERS
15	Raloxifene Hydrochloride	FAERS: 1		US FAERS
16	Rivaroxaban	FAERS: 1		US FAERS
17	Simvastatin	FAERS: 1		US FAERS
18	Sitagliptin phosphate monohydrate	FAERS: 1		US FAERS
19	Varenicline	FAERS: 1		US FAERS
20	Budesonide			OFFSIDES
21	Clonazepam			OFFSIDES
22	Clozapine			OFFSIDES
23	Cortisone			OFFSIDES
24	Cyproheptadine			OFFSIDES
25	Dicyclomine			OFFSIDES
26	Melatonin		9186818	CTD
27	Minoxidil		12789195	CTD
28	Mirtazapine			OFFSIDES
29	Nitrofurantoin			OFFSIDES
30	Nortriptyline			OFFSIDES
31	Penicillin V			OFFSIDES
32	Pioglitazone			OFFSIDES
33	Quetiapine Fumarate			OFFSIDES
34	Sertraline			OFFSIDES
35	Sulindac			OFFSIDES
36	Vardenafil Dihydrochloride			OFFSIDES
37	lanreotide		10601961	CTD
38	nefazodone			OFFSIDES
39	proligestone		11996393	CTD
40	tegaserod			OFFSIDES
41	tegaserod			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperprolactinemia	38.8%
2	Gigantism	37.4%
3	Empty Sella Syndrome	27.3%
4	Hypopituitarism	27.3%
5	Hypophysitis	27.3%
6	Pituitary Apoplexy	21.8%
7	Congenital Hypothyroidism	19.5%
8	Pituitary Adenoma	18.6%
9	Pituitary Neoplasms	18.6%
10	Osteoarthropathy, Secondary Hypertrophic	16.2%
11	Bone Diseases, Developmental	15%
12	Hyperostosis	15%
13	Osteitis	15%
14	Osteitis Deformans	15%
15	Osteochondrosis	15%
16	Spinal Diseases	15%
17	Osteochondritis	13.5%
18	Spinal Neoplasms	13.2%
19	Spondylitis	13.2%
20	Platybasia	13.2%
21	Encephalomyelitis	13%
22	Akinetic Mutism	12.9%
23	Anoxic Encephalopathy	12.9%
24	Basal Ganglia Diseases	12.9%
25	Brain Damage, Chronic	12.9%
26	Cerebellar Diseases	12.9%
27	Encephalitis	12.9%
28	Encephalomalacia	12.9%
29	Epilepsy	12.9%
30	Hydrocephalus	12.9%
31	Congenital Hydrocephalus	12.9%
32	Thalamic Diseases	12.9%
33	Intracranial Hypertension	12.9%
34	Aura	12.9%
35	Leukoencephalopathy	12.9%
36	Neuroaxonal Dystrophies	12.9%
37	Headache Disorders	12.9%
38	Intracranial Hypotension	12.9%
39	Brain Edema	12.9%
40	Brain Hypoxia	12.9%
41	Aqueductal Stenosis	12.9%
42	Prolactinoma	12.8%
43	Growth Hormone-Secreting Pituitary Adenoma	12.8%
44	Subdural Effusion	12.8%
45	Dwarfism	12.7%
46	Bone Diseases, Infectious	12.2%
47	Bone neoplasms	12.2%
48	Osteopenia	12.2%
49	Meningoencephalitis	12.2%
50	Bone Resorption	12%
51	Aseptic Necrosis of Bone	12%
52	Nelson Syndrome	10.9%
53	Pneumocephalus	10.7%
54	Brain Abscess	10.7%
55	Meningitis	10.6%
56	Movement Disorders	10.6%
57	Pachymeningitis	10.6%
58	Spinal Cord Diseases	10.6%
59	Brain Diseases, Metabolic	10.5%
60	Cerebrovascular Disorders	10.5%
61	Cerebrovascular Insufficiency	10.5%
62	Dementia	10.5%
63	Multiple System Atrophy	10.4%
64	Dandy-Walker Syndrome	10.3%
65	Parkinsonian Disorders	10.1%
66	Pectus carinatum	10.1%
67	Pectus excavatum	10%
68	Diabetes Insipidus	10%
69	Myopathy	9.9%
70	Brain Injuries	9.9%
71	Ocular Motility Disorders	9.9%
72	Cyclophoria	9.9%
73	Ainhum	9.9%
74	Dysostoses	9.9%
75	Spinal Stenosis	9.9%
76	Spondylosis	9.9%
77	Intervertebral Disc Degeneration	9.9%
78	Brain Neoplasms	9.8%
79	Discitis	9.7%
80	Dementia, Vascular	9.6%
81	Basal Ganglia Cerebrovascular Disease	9.5%
82	Posterior Leukoencephalopathy Syndrome	9.1%
83	Posterior reversible encephalopathy syndrome	9.1%
84	Lewy Body Disease	9%
85	Myelitis	8.9%
86	Central Nervous System Infection	8.9%
87	Brain Death	8.9%
88	Arthrogryposis	8.7%
89	Epilepsy, Post-Traumatic	8.7%
90	Adrenal Gland Diseases	8.6%
91	Fasciitis	8.6%
92	Foot Deformities	8.6%
93	Gonadal Disorders	8.6%
94	Arthropathy	8.6%
95	Parathyroid Diseases	8.6%
96	Thyroid Diseases	8.6%
97	Marchiafava-Bignami Disease	8.6%
98	Chronic Fatigue Syndrome	8.4%
99	Tuberculosis, Spinal	8.3%
100	Klippel-Feil Syndrome	8.3%
101	Synostosis	8.3%
102	Leukomalacia, Periventricular	8.2%
103	Meige Syndrome	8.1%
104	Osteoarthritis, Spine	8.1%
105	Cerebral Ventriculitis	8.1%
106	Contracture	8.1%
107	Fasciitis, Plantar	8.1%
108	Epidural Abscess	8.1%
109	Fibromyalgia	8%
110	Multiple Epiphyseal Dysplasia	8%
111	Osteochondrodysplasias	8%
112	Amblyopia	8%
113	Osteomyelitis	7.9%
114	Osteoporosis	7.9%
115	Periostitis	7.9%
116	Bone Demineralization, Pathologic	7.9%
117	Post-Traumatic Osteoporosis	7.9%
118	Alveolar Bone Loss	7.9%
119	Femur Head Necrosis	7.9%
120	Osteolysis	7.9%
121	Vascular Headaches	7.6%
122	Hypoxia-Ischemia, Brain	7.6%
123	Eosinophilic Granuloma	7.4%
124	Prion Diseases	7.3%
125	Stiff-Person Syndrome	7.3%
126	Chondrodysplasia Punctata	7.3%
127	Enchondromatosis	7.3%
128	Lordosis	7.3%
129	Osteosclerosis	7.3%
130	Spondylolysis	7.3%
131	kyphosis	7.3%
132	Kashin-Beck Disease	7.3%
133	Parkinson Disease	7.3%
134	Huntington Disease	7.2%
135	Neuroleptic Malignant Syndrome	7.2%
136	Myelinolysis, Central Pontine	7.2%
137	Ankylosing spondylitis	7.2%
138	Jaw Diseases	7.2%
139	Cerebral Palsy	7.1%
140	Epilepsies, Partial	7.1%
141	Epilepsy, Generalized	7.1%
142	Pseudotumor Cerebri	7.1%
143	Hypertensive Encephalopathy	7.1%
144	Simple Partial Seizures	7.1%
145	Epilepsy, Reflex	7.1%
146	Headache Disorders, Primary	7.1%
147	Headache Disorders, Secondary	7.1%
148	Medication overuse headache	7.1%
149	Cranial nerve diseases	7.1%
150	Demyelinating Diseases	7.1%
151	Demyelination	7.1%
152	Neuromuscular Diseases	7.1%
153	Chronobiology Disorders	7.1%
154	Craniofacial Dysostosis	7.1%
155	Bone Diseases, Endocrine	7%
156	Cartilage Diseases	7%
157	Endocrine Gland Neoplasms	7%
158	Foot Diseases	7%
159	Rheumatism	7%
160	Chondromalacia	7%
161	Dystonia Musculorum Deformans	6.9%
162	Diabetes Mellitus	6.9%
163	Spondylarthropathies	6.8%
164	Creutzfeldt-Jakob disease	6.8%
165	Myoclonic Epilepsy	6.8%
166	Epilepsy, Temporal Lobe	6.8%
167	Epilepsy, Rolandic	6.8%
168	Benign Rolandic Epilepsy	6.8%
169	Cerebellar Neoplasms	6.8%
170	Adrenal Gland Neoplasms	6.8%
171	Polymyalgia Rheumatica	6.8%
172	Metatarsalgia	6.7%
173	Amnesia, Transient Global	6.7%
174	Progressive supranuclear palsy	6.6%
175	Joint Tuberculosis	6.5%
176	Tuberculosis, Osteoarticular	6.5%
177	Bone Tuberculosis	6.5%
178	Subacute Combined Degeneration	6.4%
179	Spinal Cord Injuries	6.3%
180	Craniosynostosis	6.3%
181	Syndactyly	6.3%
182	Brachycephaly	6.3%
183	Acrocephalosyndactylia	6.3%
184	Spinal Muscular Atrophy	6.2%
185	Progressive Muscular Atrophy	6.2%
186	Arthritis, Psoriatic	6.1%
187	Asterixis	6.1%
188	Ballismus	6.1%
189	Melorheostosis	6.1%
190	Osteopetrosis	6.1%
191	Spondylolisthesis	6.1%
192	Limbic Encephalitis	6%
193	Presenile dementia	6%
194	Senile dementia	6%
195	Trauma, Nervous System	5.9%
196	Osteoporosis, Postmenopausal	5.9%
197	Leukoencephalopathy, Progressive Multifocal	5.8%
198	Striatonigral Degeneration	5.8%
199	Gout	5.8%
200	Parathyroid Neoplasms	5.8%
201	Thyroid Neoplasm	5.8%
202	Thyroid carcinoma	5.8%
203	Motor Neuron Disease	5.8%
204	Meningitis, Bacterial	5.7%
205	Meningitis, Fungal	5.7%
206	Nervous System Neoplasms	5.7%
207	Neurologic Manifestations	5.7%
208	Neurotoxicity Syndromes	5.7%
209	Carotid Artery Diseases	5.7%
210	Brain Ischemia	5.7%
211	Cerebrovascular accident	5.7%
212	Kluver-Bucy Syndrome	5.7%
213	Vasospasm, Intracranial	5.7%
214	Intracranial Arterial Diseases	5.7%
215	Mitochondrial Encephalomyopathies	5.7%
216	Arthritis, Reactive	5.7%
217	Ischemic contracture	5.7%
218	Rickets	5.6%
219	Amyotrophic Lateral Sclerosis	5.6%
220	Arachnoiditis	5.5%
221	Aseptic Meningitis	5.5%
222	Syringomyelia	5.5%
223	Essential Tremor	5.5%
224	Familial Tremor	5.5%
225	Pneumorrhachis	5.5%
226	Writer's Cramp	5.5%
227	Rheumatic Fever	5.5%
228	Poliomyelitis	5.5%
229	Temporomandibular Joint Disorders	5.5%
230	Myositis	5.5%
231	Isaacs syndrome	5.5%
232	Myotonic Disorders	5.5%
233	Brain Injuries, Diffuse	5.4%
234	Traumatic Brain Injury	5.4%
235	Vasculitis, Central Nervous System	5.4%
236	Cerebellar Ataxia	5.4%
237	Supratentorial Neoplasms	5.4%
238	Hepatolenticular Degeneration	5.4%
239	Hip Contracture	5.3%
240	Periarthritis	5.3%
241	Lupus Vasculitis, Central Nervous System	5.2%
242	Paraneoplastic Cerebellar Degeneration	5.1%
243	Poland Syndrome	5.1%
244	Persistent Vegetative State	5.1%
245	Shy-Drager Syndrome	5.1%
246	Adrenal Cortex Diseases	5%
247	Arthritis	5%
248	Bursitis	5%
249	Euthyroid Sick Syndromes	5%
250	Goiter	5%
251	Hyperparathyroidism	5%
252	Hyperthyroidism	5%
253	Hyperthyroxinemia	5%
254	Hypogonadism	5%
255	Hypoparathyroidism	5%
256	Hypothyroidism	5%
257	Joint Instability	5%
258	Myofascial Pain Syndromes	5%
259	Delayed Puberty	5%
260	Precocious Puberty	5%
261	Rhabdomyolysis	5%
262	Synovitis	5%
263	Thyroiditis	5%
264	Joint laxity	5%
265	Polyarthritis	5%
266	Hypogonadotropic hypogonadism	5%
267	Frozen shoulder	5%
268	Patellofemoral Pain Syndrome	5%
269	Testotoxicosis	5%
270	Secondary hypothyroidism	5%
271	Primary Hyperthyroidism	5%
272	Primary Hypothyroidism	5%
273	Basal Ganglia Hemorrhage	5%
274	Osteogenesis Imperfecta	5%
275	Goldenhar Syndrome	5%
276	Restless Legs Syndrome	4.9%
277	Temporomandibular Joint Dysfunction Syndrome	4.9%
278	Spinal Cord Neoplasms	4.9%
279	Pseudohypoparathyroidism	4.9%
280	Talipes	4.9%
281	Mastoiditis	4.9%
282	Petrositis	4.9%
283	Mandibulofacial Dysostosis	4.9%
284	Sleep Wake Disorders	4.9%
285	Brain Infarction	4.8%
286	Rheumatoid Arthritis	4.8%
287	Juvenile arthritis	4.8%
288	Toxoplasmosis, Cerebral	4.8%
289	Reye Syndrome	4.8%
290	Ophthalmoplegic Migraine	4.8%
291	Intracranial Embolism and Thrombosis	4.8%
292	Hepatic Encephalopathy	4.8%
293	Brain Hemorrhage, Traumatic	4.8%
294	MPTP Poisoning	4.7%
295	Rubinstein-Taybi Syndrome	4.7%
296	Polyradiculoneuropathy	4.7%
297	Polyradiculoneuritis	4.7%
298	Antley-Bixler Syndrome Phenotype	4.7%
299	Medial Tibial Stress Syndrome	4.6%
300	Leukoencephalitis, Acute Hemorrhagic	4.6%
301	Carotid Artery Injuries	4.6%
302	Akathisia, Drug-Induced	4.6%
303	Mitochondrial Myopathies	4.6%
304	Osteoarthritis, Knee	4.6%
305	Muscle Cramp	4.6%
306	Eosinophilia-Myalgia Syndrome	4.6%
307	Encephalomyelitis, Acute Disseminated	4.6%
308	Miller Fisher Syndrome	4.5%
309	Juvenile Myoclonic Epilepsy	4.5%
310	Myoclonic Epilepsies, Progressive	4.5%
311	Central Nervous System Fungal Infections	4.5%
312	Conus Medullaris Syndrome	4.5%
313	Spinal Cord Vascular Diseases	4.5%
314	Autonomic Dysreflexia	4.3%
315	Complex Regional Pain Syndromes	4.3%
316	Post-Traumatic Headache	4.3%
317	Tension Headache	4.3%
318	Epilepsy, Complex Partial	4.3%
319	Migraine Disorders	4.3%
320	Abdominal Migraine	4.3%
321	Status Migrainosus	4.3%
322	Cervicogenic Headache	4.3%
323	Myelitis, Transverse	4.2%
324	Palatal Neoplasms	4.2%
325	Friedreich Ataxia	4.2%
326	Osteomalacia	4.2%
327	Opsoclonus-Myoclonus Syndrome	4.1%
328	ovarian neoplasm	4.1%
329	Cockayne Syndrome	4.1%
330	Diabetic Neuropathies	4.1%
331	Diabetic Amyotrophy	4.1%
332	Diabetic Autonomic Neuropathy	4.1%
333	Brain Diseases, Metabolic, Inborn	4.1%
334	Basal Cell Nevus Syndrome	4.1%
335	Compartment syndromes	4.1%
336	Maxillary Diseases	4.1%
337	Tendinitis	4.1%
338	Testicular Diseases	4.1%
339	Tendinopathy	4.1%
340	Arthritis, Gouty	4.1%
341	Marfan Syndrome	4%
342	Hemarthrosis	4%
343	Tietze's Syndrome	4%
344	Limb Deformities, Congenital	4%
345	Craniofacial Abnormalities	4%
346	Ovarian Diseases	4%
347	Muscle Rigidity	4%
348	Muscle Spasticity	4%
349	Cogwheel Rigidity	4%
350	Nuchal Rigidity	4%
351	Muscle Weakness	4%
352	Canavan Disease	3.9%
353	Alexander Disease	3.9%
354	Familial Periodic Paralysis	3.9%
355	Renal Osteodystrophy	3.9%
356	Renal rickets	3.9%
357	MELAS Syndrome	3.8%
358	Graves Disease	3.8%
359	Rheumatoid Nodule	3.8%
360	Dyskinesia, Drug-Induced	3.8%
361	Central Nervous System Bacterial Infections	3.8%
362	Congenital clubfoot	3.8%
363	Vertical Talus	3.8%
364	Thyroid Nodule	3.7%
365	Testicular Neoplasms	3.7%
366	Myotonic Dystrophy	3.7%
367	Peripheral Nerve Injuries	3.7%
368	Adrenocortical carcinoma	3.6%
369	Auditory Perceptual Disorders	3.6%
370	Myasthenia Gravis	3.6%
371	Wernicke Encephalopathy	3.6%
372	AIDS Dementia Complex	3.6%
373	Adrenoleukodystrophy	3.6%
374	Dysautonomia	3.5%
375	Vagus Nerve Disorder	3.5%
376	Glossopharyngeal Neuralgia	3.5%
377	Abducens Nerve Diseases	3.5%
378	Heavy Metal Poisoning, Nervous System	3.5%
379	Neuromuscular Junction Diseases	3.5%
380	Tauopathies	3.5%
381	Trochlear Nerve Diseases	3.5%
382	Peripheral Nervous System Diseases	3.5%
383	Moyamoya Disease	3.5%
384	Myotonia Congenita	3.5%
385	Lafora Disease	3.5%
386	Unverricht-Lundborg Syndrome	3.5%
387	Polymyositis	3.4%
388	Putaminal Hemorrhage	3.4%
389	Cerebral Arterial Diseases	3.4%
390	Vertebrobasilar Insufficiency	3.4%
391	Basilar Artery Stenosis	3.4%
392	Vertebral Artery Stenosis	3.4%
393	Intracranial Hemorrhage, Hypertensive	3.4%
394	Transient Cerebral Ischemia	3.4%
395	Myalgia	3.4%
396	Gestational Diabetes	3.4%
397	Latent Autoimmune Diabetes in Adults	3.4%
398	Diabetes Mellitus, Experimental	3.3%
399	Scrapie	3.3%
400	Gastroschisis	3.3%
401	Central Cord Syndrome	3.3%
402	Tuberculosis, Meningeal	3.3%
403	Jaw Abnormalities	3.3%
404	Bunion	3.3%
405	Cushing Syndrome	3.3%
406	Fibrodysplasia Ossificans Progressiva	3.3%
407	Hyperaldosteronism	3.3%
408	Hyperparathyroidism, Secondary	3.3%
409	Hypoaldosteronism	3.3%
410	Myoglobinuria	3.3%
411	Myositis Ossificans	3.3%
412	Tenosynovitis	3.3%
413	Thyrotoxicosis	3.3%
414	Hyperparathyroidism, Primary	3.3%
415	Sacroiliitis	3.3%
416	Thyroid Hormone Resistance Syndrome	3.3%
417	Felty Syndrome	3.3%
418	Chorea	3.3%
419	Kernicterus	3.2%
420	Lambert-Eaton Myasthenic Syndrome	3.2%
421	Diffuse Axonal Injury	3.2%
422	Brain Stem Neoplasms	3.2%
423	Cerebral Infarction	3.2%
424	Brain Stem Infarctions	3.2%
425	Sleep Disorders, Circadian Rhythm	3.2%
426	Prognathism	3.1%
427	Infarction, Middle Cerebral Artery	3.1%
428	Infarction, Anterior Cerebral Artery	3.1%
429	Infarction, Posterior Cerebral Artery	3.1%
430	Botulism	3.1%
431	Central Nervous System Cysts	3.1%
432	Guillain-Barre Syndrome	3.1%
433	Vertebral Artery Dissection	3.1%
434	Nose Neoplasms	3%
435	Frontotemporal dementia	3%
436	Progressive bulbar palsy	3%
437	Bulbar palsy	3%
438	Optic Neuropathy	3%
439	Muscular Dystrophy	2.9%
440	Orbital Myositis	2.9%
441	Hermaphroditism	2.9%
442	Nail-Patella Syndrome	2.9%
443	Disorders of Sex Development	2.9%
444	Facial Nerve Diseases	2.9%
445	Craniocerebral Trauma	2.9%
446	Parasomnia	2.9%
447	Dyssomnias	2.9%
448	Giant Cell Epulis	2.9%
449	Pyomyositis	2.9%
450	Rheumatoid Vasculitis	2.9%
451	Carotid Stenosis	2.8%
452	Intracranial Aneurysm	2.8%
453	Musculoskeletal Pain	2.8%
454	Vestibulocochlear Nerve Diseases	2.8%
455	Decerebrate State	2.8%
456	Hemiparesis	2.8%
457	Hydranencephaly	2.8%
458	Meningism	2.8%
459	Neural Tube Defects	2.8%
460	Paresis	2.8%
461	Seizures	2.8%
462	Sensation Disorders	2.8%
463	Tethered Cord Syndrome	2.8%
464	Central Nervous System Neoplasms	2.8%
465	Complex partial seizures	2.8%
466	Iniencephaly	2.8%
467	Craniorachischisis	2.8%
468	Exencephaly	2.8%
469	Monoparesis	2.8%
470	Septo-Optic Dysplasia	2.8%
471	Cortical Dysplasia	2.8%
472	Neurogenic Inflammation	2.8%
473	Gait Disorders, Neurologic	2.8%
474	Neuromuscular Manifestations	2.8%
475	Malformations of Cortical Development	2.8%
476	Intracranial Arteriosclerosis	2.8%
477	Cerebral Atherosclerosis	2.8%
478	Cluster Headache	2.8%
479	Subarachnoid Hemorrhage	2.8%
480	Migraine with Aura	2.8%
481	Familial Hemiplegic Migraine	2.8%
482	Chronic Paroxysmal Hemicrania	2.8%
483	Cerebral Arteriosclerosis	2.8%
484	SUNCT Syndrome	2.8%
485	Paroxysmal Hemicrania	2.8%
486	Cerebral Hemorrhage	2.8%
487	Cerebral Thrombosis	2.8%
488	Intracranial Embolism	2.8%
489	Intracranial Thrombosis	2.8%
490	Arthralgia	2.8%
491	Polyarthralgia	2.8%
492	Sweating, Gustatory	2.8%
493	Auriculotemporal Syndrome	2.8%
494	Meningitis, Cryptococcal	2.8%
495	Diabetic Foot	2.8%
496	Meningitis, Listeria	2.8%
497	Brain Contusion	2.8%
498	Meningitis, Haemophilus	2.8%
499	Meningitis, Pneumococcal	2.8%
500	Ataxia Telangiectasia	2.8%
501	Torticollis	2.7%
502	Olfactory Nerve Injuries	2.7%
503	Addison Disease	2.7%
504	Arthritis, Infectious	2.7%
505	Diabetic Angiopathies	2.7%
506	Autoimmune thyroiditis	2.7%
507	Primary Adrenal Insufficiency	2.7%
508	Subarachnoid Hemorrhage, Traumatic	2.7%
509	Carotid Artery, Internal, Dissection	2.7%
510	Anterior Compartment Syndrome	2.6%
511	Myxedema	2.6%
512	Orchitis	2.6%
513	Enthesopathy	2.6%
514	Diabetic Cardiomyopathies	2.6%
515	Arthritis, Experimental	2.6%
516	Abdominal Compartment Syndrome	2.6%
517	Subacute Sclerosing Panencephalitis	2.6%
518	Amelia	2.6%
519	Arachnodactyly	2.6%
520	Ectromelia	2.6%
521	Hemimelia	2.6%
522	Phocomelia	2.6%
523	Sirenomelia	2.6%
524	Polydactyly	2.6%
525	Brachydactyly	2.6%
526	Plagiocephaly	2.6%
527	Lower Extremity Deformities, Congenital	2.6%
528	Upper Extremity Deformities, Congenital	2.6%
529	Ovarian Hyperstimulation Syndrome	2.6%
530	Brain Concussion	2.6%
531	Horner Syndrome	2.6%
532	Causalgia	2.6%
533	Sicca Syndrome	2.5%
534	Kallmann Syndrome	2.5%
535	Sjogren's Syndrome	2.5%
536	Multiple Endocrine Neoplasia	2.5%
537	Pancreatic Neoplasm	2.5%
538	Laryngomalacia	2.5%
539	granulosa cell tumor	2.5%
540	Carcinoma, Ovarian Epithelial	2.5%
541	Multiple Sclerosis	2.5%
542	Spinal Cord Ischemia	2.5%
543	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.5%
544	Neuromyelitis Optica	2.4%
545	Pupil Disorders	2.4%
546	Neurobehavioral Manifestations	2.4%
547	Hyperglycemic Hyperosmolar Nonketotic Coma	2.4%
548	Hashimoto Disease	2.4%
549	Giant Cell Arteritis	2.4%
550	Temporal Arteritis	2.4%
551	Microcephaly	2.4%
552	Macrocephaly	2.4%
553	Hypokalemic periodic paralysis	2.4%
554	Tuberculosis, Central Nervous System	2.4%
555	Carotid Artery Thrombosis	2.4%
556	Lateral Medullary Syndrome	2.4%
557	Paraneoplastic Encephalomyelitis	2.4%
558	Uveomeningoencephalitic Syndrome	2.4%
559	Facial Nerve Injuries	2.4%
560	Sturge-Weber Syndrome	2.4%
561	Vertigo	2.4%
562	Alcohol-Induced Disorders, Nervous System	2.4%
563	Micrognathism	2.3%
564	Pierre Robin Syndrome	2.3%
565	Reflex Sympathetic Dystrophy	2.3%
566	Nocturnal Myoclonus Syndrome	2.3%
567	Jet Lag Syndrome	2.3%
568	Klinefelter Syndrome	2.3%
569	Subclavian Steal Syndrome	2.3%
570	Pick Disease of the Brain	2.3%
571	Hip Dislocation	2.3%
572	Shoulder Dislocation	2.3%
573	Hip Dysplasia	2.3%
574	Corpus Luteum Cyst	2.2%
575	Ovarian Cysts	2.2%
576	Dupuytren Contracture	2.2%
577	Refsum Disease	2.2%
578	Diabetic Nephropathy	2.2%
579	Tuberous Sclerosis	2.2%
580	Anovulation	2.2%
581	Diabetic Ketoacidosis	2.2%
582	Oophoritis	2.2%
583	Alice in Wonderland Syndrome	2.2%
584	Choroid Plexus Papilloma	2.1%
585	Ophthalmoplegia	2.1%
586	External Ophthalmoplegia	2.1%
587	Retrognathia	2.1%
588	Waterhouse-Friderichsen Syndrome	2.1%
589	Myasthenia Gravis, Autoimmune, Experimental	2.1%
590	Voice Disorders	2.1%
591	Voice Disturbance	2.1%
592	Holoprosencephaly	2.1%
593	Neuroaspergillosis	2.1%
594	Welander Distal Myopathy	2%
595	Smith-Magenis syndrome	2%
596	Dural Arteriovenous Fistula	2%
597	Porencephaly	2%
598	Cryptorchidism	1.9%
599	Acrodynia	1.9%
600	Maxillofacial Abnormalities	1.9%
601	Galactosemias	1.9%
602	Urea Cycle Disorders, Inborn	1.9%
603	Tyrosinemias	1.9%
604	Vocal Cord Paralysis	1.9%
605	Tardive Dyskinesia	1.9%
606	Cerebral Amyloid Angiopathy	1.9%
607	Sinus Thrombosis, Intracranial	1.9%
608	Gonadal Dysgenesis	1.9%
609	Bronchomalacia	1.9%
610	Adrenogenital Syndrome	1.9%
611	Tracheomalacia	1.9%
612	Ovotesticular Disorders of Sex Development	1.9%
613	Shoulder Pain	1.8%
614	Neuritis	1.8%
615	Polyneuritis	1.8%
616	Radiculitis	1.8%
617	Polyneuropathy	1.8%
618	Mononeuritis	1.8%
619	Mononeuropathies	1.8%
620	Brachial Plexus Neuropathies	1.8%
621	Radiculopathy	1.8%
622	Mononeuropathy Multiplex	1.8%
623	Nerve Root Compression	1.8%
624	Pseudorabies	1.8%
625	Dermatomyositis	1.8%
626	Cleft Palate	1.8%
627	Leydig Cell Tumor	1.8%
628	Hyperandrogenism	1.8%
629	Reflex, Abnormal	1.8%
630	Hyporeflexia	1.8%
631	Hyperreflexia	1.8%
632	Muscular Dystrophy, Duchenne	1.8%
633	Neurosyphilis	1.7%
634	Charcot-Marie-Tooth Disease	1.7%
635	Homocystinuria	1.7%
636	Hematoma, Subdural	1.7%
637	Hematoma, Epidural, Cranial	1.7%
638	Leigh Disease	1.7%
639	Fabry Disease	1.7%
640	Diabetic Retinopathy	1.7%
641	West Nile Fever	1.7%
642	Multiple Endocrine Neoplasia Type 1	1.6%
643	Alcohol Withdrawal Seizures	1.6%
644	Cerebrospinal Fluid Otorrhea	1.6%
645	Cerebrospinal Fluid Rhinorrhea	1.6%
646	Neuritis, Autoimmune, Experimental	1.6%
647	Polycystic Ovary Syndrome	1.6%
648	Brachial Plexus Neuritis	1.6%
649	Gait Ataxia	1.6%
650	Neuralgic Amyotrophy	1.6%
651	Familial Hypophosphatemic Rickets	1.6%
652	Lyme Neuroborreliosis	1.5%
653	Optic Atrophy	1.5%
654	Optic Neuritis	1.5%
655	Papilledema	1.5%
656	Strabismus	1.5%
657	Tolosa-Hunt Syndrome	1.5%
658	Arsenic Poisoning	1.5%
659	Myasthenic Syndromes, Congenital	1.5%
660	Coma, Post-Head Injury	1.5%
661	Menkes Kinky Hair Syndrome	1.5%
662	Facial Injuries	1.5%
663	Facial Neuralgia	1.5%
664	Sleep Talking	1.5%
665	Manganese Poisoning	1.5%
666	Sleep Disorders, Intrinsic	1.5%
667	Orthostatic intolerance	1.5%
668	Anosmia	1.5%
669	Ataxia	1.5%
670	Athetosis	1.5%
671	Catalepsy	1.5%
672	Dystonia	1.5%
673	Hemiplegia	1.5%
674	Locked-In Syndrome	1.5%
675	Meningeal Neoplasms	1.5%
676	Meningomyelocele	1.5%
677	Muscle Hypertonia	1.5%
678	Muscle hypotonia	1.5%
679	Myoclonus	1.5%
680	Myotonia	1.5%
681	Neuralgia	1.5%
682	Paraplegia	1.5%
683	Pseudobulbar Palsy	1.5%
684	Quadriplegia	1.5%
685	Spasm	1.5%
686	Spastic Paraplegia	1.5%
687	Status Epilepticus	1.5%
688	Taste Disorders	1.5%
689	Tremor	1.5%
690	Spina Bifida	1.5%
691	Monoplegia	1.5%
692	Hypokinesia	1.5%
693	Paraparesis	1.5%
694	Bradykinesia	1.5%
695	Waxy flexibility	1.5%
696	Action Tremor	1.5%
697	Resting Tremor	1.5%
698	Dysosmia	1.5%
699	Quadriparesis	1.5%
700	Mercury Poisoning, Nervous System	1.5%
701	Olfaction Disorders	1.5%
702	Myokymia	1.5%
703	Lead Poisoning, Nervous System	1.5%
704	Vestibular Neuronitis	1.5%
705	Somatosensory Disorders	1.5%
706	Neuropathic pain	1.5%
707	Hyperkinesia	1.5%
708	Intention tremor	1.5%
709	Noonan Syndrome	1.5%
710	Anterior Spinal Artery Syndrome	1.5%
711	Akathisia	1.4%
712	Restlessness	1.4%
713	Psychomotor Agitation	1.4%
714	Cavernous Sinus Thrombosis	1.4%
715	Sagittal Sinus Thrombosis	1.4%
716	Multiple Sclerosis, Chronic Progressive	1.3%
717	Multiple Sclerosis, Relapsing-Remitting	1.3%
718	Zellweger Syndrome	1.3%
719	Carcinoma, Pancreatic Ductal	1.3%
720	Kearns-Sayre syndrome	1.3%
721	Tarsal Tunnel Syndrome	1.3%
722	Cauda Equina Syndrome	1.3%
723	Hand-Arm Vibration Syndrome	1.3%
724	Vision Disorders	1.3%
725	Metamorphopsia	1.3%
726	Visual Impairment	1.3%
727	Optic Neuropathy, Ischemic	1.3%
728	Anterior Ischemic Optic Neuropathy	1.3%
729	Facial Hemiatrophy	1.3%
730	Melkersson-Rosenthal Syndrome	1.3%
731	Anisocoria	1.2%
732	Confusion	1.2%
733	Facial paralysis	1.2%
734	Lethargy	1.2%
735	Memory Disorders	1.2%
736	Perceptual Disorders	1.2%
737	Psychomotor Disorders	1.2%
738	Tonic Pupil	1.2%
739	Anhedonia	1.2%
740	Disorientation	1.2%
741	Facial Paresis	1.2%
742	Memory Loss	1.2%
743	Hemisensory Neglect	1.2%
744	Dysacusis	1.2%
745	Sleep Bruxism	1.2%
746	Toxoplasmosis, Congenital	1.2%
747	Anencephaly	1.2%
748	Meningocele	1.2%
749	Muscular Atrophy	1.2%
750	Respiratory Paralysis	1.2%
751	Encephalocele	1.2%
752	Malaria, Cerebral	1.2%
753	Tetany	1.2%
754	Acoustic Neuroma	1.2%
755	Neurocysticercosis	1.2%
756	Gait Apraxia	1.2%
757	Turner Syndrome	1.2%
758	Hematoma, Subdural, Intracranial	1.2%
759	Hematoma, Subdural, Chronic	1.2%
760	Hematoma, Subdural, Acute	1.2%
761	Alstrom Syndrome	1.2%
762	Amyloid Neuropathies, Familial	1.1%
763	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.1%
764	Optic Nerve Glioma	1.1%
765	Carpal Tunnel Syndrome	1.1%
766	Duane Retraction Syndrome	1.1%
767	neurofibroma	1.1%
768	Consciousness Disorders	1.1%
769	Mental Retardation	1.1%
770	Depressed Level of Consciousness	1.1%
771	Mental deficiency	1.1%
772	Intellectual Disability	1.1%
773	Sciatica	1.1%
774	insulinoma	1.1%
775	Gastrinoma	1.1%
776	Glucagonoma	1.1%
777	Mobius Syndrome	1.1%
778	Bell Palsy	1.1%
779	Catatonia	1.1%
780	Carcinoma, Endometrioid	1.1%
781	Herpes Zoster Oticus	1.1%
782	Aphonia	1.1%
783	Sleep Deprivation	1.1%
784	Dysphonia	1.1%
785	Sciatic Neuropathy	1%
786	Ulnar Neuropathies	1%
787	Lesion of Sciatic Nerve	1%
788	Ulnar Neuritis	1%
789	Radial nerve compression	1%
790	Radial Tunnel Syndrome	1%
791	Peroneal Neuropathies	1%
792	Radial Neuropathy	1%
793	Median Neuropathy	1%
794	Sciatic Nerve Palsy	1%
795	Femoral Neuropathy	1%
796	Tibial Neuropathy	1%
797	Ulnar Nerve Palsy	1%
798	Postural Orthostatic Tachycardia Syndrome	1%
799	Radial nerve palsy	1%
800	Glycogen storage disease type II	1%
801	Radicular Cyst	1%
802	Vipoma	1%
803	Neuronal Ceroid-Lipofuscinoses	0.9%
804	Aicardi's syndrome	0.8%
805	Hoarseness	0.8%
806	Thoracic Outlet Syndrome	0.8%
807	Alcohol Withdrawal Delirium	0.8%
808	Esotropia	0.8%
809	Exotropia	0.8%
810	Hypotension, Orthostatic	0.8%
811	Sleep Apnea Syndromes	0.8%
812	Post-Exercise Hypotension	0.8%
813	Disorders of Excessive Somnolence	0.8%
814	Sleep Initiation and Maintenance Disorders	0.8%
815	Night Terrors	0.8%
816	Somnambulism	0.8%
817	Trigeminal Nerve Disorder	0.8%
818	Transient Insomnia	0.8%
819	Sleep Paralysis	0.8%
820	Chronic Insomnia	0.8%
821	REM Sleep Behavior Disorder	0.8%
822	Hypersomnia	0.8%
823	Dermal Sinus	0.8%
824	Dysgeusia	0.8%
825	Formication	0.8%
826	Hyperalgesia	0.8%
827	Hyperesthesia	0.8%
828	Hypesthesia	0.8%
829	Language Disorders	0.8%
830	Numbness	0.8%
831	Paresthesia	0.8%
832	Paraparesis, Spastic	0.8%
833	Spina Bifida Cystica	0.8%
834	Trismus	0.8%
835	Spina Bifida Occulta	0.8%
836	Epilepsia Partialis Continua	0.8%
837	Hypogeusia	0.8%
838	Meningeal Carcinomatosis	0.8%
839	Brown-Sequard Syndrome	0.8%
840	Lissencephaly	0.8%
841	Polymicrogyria	0.8%
842	Pachygyria	0.8%
843	Schizencephaly	0.8%
844	Lockjaw	0.8%
845	Allodynia	0.8%
846	Lead Poisoning, Nervous System, Childhood	0.8%
847	Lead Poisoning, Nervous System, Adult	0.8%
848	Periventricular Nodular Heterotopia	0.8%
849	Ageusia	0.8%
850	Cubital Tunnel Syndrome	0.8%
851	Classical Lissencephalies and Subcortical Band Heterotopias	0.8%
852	Eye Injuries	0.7%
853	Gaucher Disease	0.7%
854	Congenital nystagmus	0.7%
855	Diplopia	0.7%
856	Scotoma	0.7%
857	Photophobia	0.7%
858	Hemifacial Spasm	0.7%
859	Amaurosis	0.7%
860	Blindness	0.7%
861	Agnosia	0.7%
862	Apraxias	0.7%
863	Hallucinations	0.7%
864	Hemianopsia	0.7%
865	Hyperacusis	0.7%
866	Tinnitus	0.7%
867	Visual Agnosia	0.7%
868	Anosognosia	0.7%
869	Wernicke-Korsakoff Syndrome	0.7%
870	Phonophobia	0.7%
871	Hearing Loss	0.7%
872	Sarcopenia	0.7%
873	Optic Atrophy, Hereditary, Leber	0.7%
874	Denys-Drash Syndrome	0.6%
875	Polyradiculopathy	0.6%
876	Alexia	0.6%
877	Dyslexia	0.6%
878	Amnesia	0.6%
879	Delirium	0.6%
880	Dissociative Amnesia	0.6%
881	Color blindness	0.6%
882	Global Amnesia	0.6%
883	Cri-du-Chat Syndrome	0.6%
884	Down Syndrome	0.6%
885	Trisomy 21	0.6%
886	POEMS Syndrome	0.6%
887	Meningioma	0.6%
888	Williams Syndrome	0.6%
889	Niemann-Pick Disease, Type C	0.5%
890	Tay-Sachs Disease	0.5%
891	Prader-Willi Syndrome	0.5%
892	Phantom pain	0.5%
893	Phantom Limb Pain	0.5%
894	Neurofibrosarcoma	0.5%
895	Sleep Apnea, Obstructive	0.5%
896	Sleep Apnea, Central	0.5%
897	Narcolepsy	0.5%
898	Trigeminal Neuralgia	0.5%
899	Kleine-Levin Syndrome	0.5%
900	Agraphia	0.5%
901	Anomia	0.5%
902	Cluttering	0.5%
903	Language Development Disorders	0.5%
904	Speech Disorders	0.5%
905	Syncope	0.5%
906	Stupor	0.5%
907	Dysgraphia	0.5%
908	Presyncope	0.5%
909	Dyslalia	0.5%
910	Eye Burns	0.4%
911	Amaurosis Fugax	0.4%
912	Blindness, Cortical	0.4%
913	Dyscalculia	0.4%
914	Rett Syndrome	0.4%
915	Deafness	0.4%
916	Hearing Loss, Sudden	0.4%
917	Gerstmann Syndrome	0.4%
918	Hearing Loss, Bilateral	0.4%
919	Hearing Loss, High-Frequency	0.4%
920	Hearing Loss, Mixed Conductive-Sensorineural	0.4%
921	Prosopagnosia	0.4%
922	Apraxia, Ideomotor	0.4%
923	Charles Bonnet Syndrome	0.4%
924	Hearing Loss, Unilateral	0.4%
925	Complete Hearing Loss	0.4%
926	Alien Hand Syndrome	0.4%
927	Deaf Mutism	0.4%
928	Corneal Scar	0.4%
929	Retrograde amnesia	0.3%
930	Amnesia, Anterograde	0.3%
931	Cataplexy	0.3%
932	Aphasia	0.3%
933	Articulation Disorders	0.3%
934	Echolalia	0.3%
935	Stuttering	0.3%
936	Dysphasia	0.3%
937	Fragile X Syndrome	0.3%
938	Mutism	0.3%
939	Selective Mutism	0.3%
940	Dysarthria	0.2%
941	Corneal Perforation	0.2%
942	Mucopolysaccharidosis II	0.2%
943	Alexia, Pure	0.2%

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