MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Chondromalacia

(UMLS:C0085700)

Definition:: Softening and degeneration of the CARTILAGE.
UMLS ID:: C0085700
MeSH ID:: D002357

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.182

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.182

Synonym(s)

Chondromalacia

CHONDROMALACIA

Chondromalacia, NOS

Chondromalacia, site unspecified

Chondromalacia, unspecified site

chondromalacia

joint cartilage softening

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 13	US FAERS
2	rofecoxib	FAERS: 11	OFFSIDES US FAERS
3	Zoledronic Acid	FAERS: 4	OFFSIDES US FAERS
4	Levofloxacin	FAERS: 3	US FAERS
5	Teriparatide	FAERS: 3	US FAERS
6	Marcaine hydrochloride w/epinephrine	FAERS: 2	US FAERS
7	Bupivacaine	FAERS: 1	US FAERS
8	Fingolimod Hydrochloride	FAERS: 1	US FAERS
9	Imatinib Mesylate	FAERS: 1	US FAERS
10	Isotretinoin	FAERS: 1	US FAERS
11	Pregabalin	FAERS: 1	US FAERS
12	valdecoxib	FAERS: 1	OFFSIDES US FAERS
13	Allopurinol		OFFSIDES
14	Amiloride		OFFSIDES
15	Amisulpride		OFFSIDES
16	Amitriptyline		OFFSIDES
17	Bupivacaine		OFFSIDES
18	Buprenorphine		OFFSIDES
19	Celecoxib		OFFSIDES
20	Chlorhexidine		OFFSIDES
21	Ciclopirox		OFFSIDES
22	Cimetidine		OFFSIDES
23	Cortisone		OFFSIDES
24	Cortisone		OFFSIDES
25	D-Galactosamine		OFFSIDES
26	Diphenoxylate		OFFSIDES
27	Doxorubicin		OFFSIDES
28	Ephedrine		OFFSIDES
29	Fondaparinux		OFFSIDES
30	Fosinopril		OFFSIDES
31	Fulvestrant		OFFSIDES
32	Glipizide		OFFSIDES
33	Hydralazine		OFFSIDES
34	Ipratropium		OFFSIDES
35	Lisinopril		OFFSIDES
36	Loratadine		OFFSIDES
37	Meloxicam		OFFSIDES
38	Methocarbamol		OFFSIDES
39	Methylprednisolone Acetate		OFFSIDES
40	Nabumetone		OFFSIDES
41	Octreotide		OFFSIDES
42	Olopatadine Hydrochloride		OFFSIDES
43	Paclitaxel		OFFSIDES
44	Pamidronate		OFFSIDES
45	Paroxetine		OFFSIDES
46	Penicillin V		OFFSIDES
47	Pramipexole		OFFSIDES
48	Progesterone		OFFSIDES
49	Pyridoxine		OFFSIDES
50	Quinidine		OFFSIDES
51	Raloxifene Hydrochloride		OFFSIDES
52	Salmeterol Xinafoate		OFFSIDES
53	Selenium		OFFSIDES
54	Terbinafine		OFFSIDES
55	Thyroxine		OFFSIDES
56	Topiramate		OFFSIDES
57	Tretinoin		OFFSIDES
58	Triamterene		OFFSIDES
59	Ubiquinone		OFFSIDES
60	Valacyclovir		OFFSIDES
61	azelastine		OFFSIDES
62	brinzolamide		OFFSIDES
63	cefprozil		OFFSIDES
64	cevimeline		OFFSIDES
65	chlordiazepoxide, clidinium drug combination		OFFSIDES
66	chlorhexidine gluconate		OFFSIDES
67	cyclobenzaprine		OFFSIDES
68	desloratadine		OFFSIDES
69	dolasetron		OFFSIDES
70	metaxalone		OFFSIDES
71	ropinirole		OFFSIDES
72	samarium Sm-153 lexidronam		OFFSIDES
73	tegaserod		OFFSIDES
74	tegaserod		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Rheumatism	38.5%
2	Polymyalgia Rheumatica	30.4%
3	Collagen Diseases	30%
4	Mixed Connective Tissue Disease	30%
5	Mucinoses	30%
6	Lupus Erythematosus, Cutaneous	29.6%
7	Panniculitis	29.6%
8	Systemic Scleroderma	29.6%
9	Morphea	29.6%
10	Panniculitis, Lupus Erythematosus	25.3%
11	Dermatomyositis	24%
12	Dupuytren Contracture	24%
13	Rheumatoid Arthritis	23.8%
14	Juvenile arthritis	23.8%
15	Rheumatoid Nodule	23.6%
16	Foot Diseases	23.1%
17	Contracture	22.2%
18	Lupus Erythematosus, Systemic	22.2%
19	Osteoarthropathy, Secondary Hypertrophic	22.2%
20	Fasciitis, Plantar	22.2%
21	Overlap syndrome	22.2%
22	Scleromyxedema	22%
23	Arthrogryposis	21.7%
24	Cutis Laxa	21.4%
25	Lupus Erythematosus, Discoid	21.4%
26	Scleroderma, Limited	21.4%
27	Bone Diseases	21.1%
28	Fasciitis	21.1%
29	Foot Deformities	21.1%
30	Arthropathy	21.1%
31	Osteoarthritis, Spine	20.8%
32	Felty Syndrome	19.5%
33	Osteogenesis Imperfecta	19.1%
34	Ankylosing spondylitis	18.4%
35	Arthritis, Psoriatic	18%
36	Hip Contracture	17.9%
37	Periarthritis	17.9%
38	Ischemic contracture	17.4%
39	Fibromyalgia	17.4%
40	Platybasia	17.3%
41	Metatarsalgia	17.3%
42	Osteoarthritis, Knee	16.8%
43	Rheumatoid Vasculitis	16.6%
44	Mesenteric Panniculitis	16.4%
45	Panniculitis, Peritoneal	16.4%
46	Orbital Cellulitis	16.4%
47	Myxoid cyst	16.4%
48	Talipes	16.3%
49	Myxedema	16.1%
50	Temporomandibular Joint Dysfunction Syndrome	16%
51	Jaw Diseases	16%
52	Gout	15.8%
53	Temporomandibular Joint Disorders	15.8%
54	Pectus excavatum	15.7%
55	Necrobiosis Lipoidica Diabeticorum	15.6%
56	Rheumatic Fever	15.6%
57	Myopathy	15.4%
58	Spondylarthropathies	15.3%
59	Arthritis	15%
60	Bone Diseases, Developmental	15%
61	Bursitis	15%
62	Hyperostosis	15%
63	Joint Instability	15%
64	Myofascial Pain Syndromes	15%
65	Osteitis	15%
66	Osteitis Deformans	15%
67	Osteochondrosis	15%
68	Rhabdomyolysis	15%
69	Spinal Diseases	15%
70	Synovitis	15%
71	Joint laxity	15%
72	Polyarthritis	15%
73	Frozen shoulder	15%
74	Patellofemoral Pain Syndrome	15%
75	Klippel-Feil Syndrome	14.9%
76	Synostosis	14.9%
77	Congenital clubfoot	14.8%
78	Vertical Talus	14.8%
79	Granuloma Annulare	14.7%
80	Noonan Syndrome	14.7%
81	Arthritis, Reactive	14.6%
82	Sicca Syndrome	14.5%
83	Sjogren's Syndrome	14.5%
84	Acrocephalosyndactylia	14.4%
85	Gigantism	14.1%
86	Spinal Neoplasms	14.1%
87	Spondylitis	14.1%
88	Cellulitis	14%
89	Craniosynostosis	13.9%
90	Syndactyly	13.9%
91	Brachycephaly	13.9%
92	Pseudoxanthoma Elasticum	13.8%
93	Arthritis, Gouty	13.5%
94	Craniofacial Dysostosis	13.2%
95	Marfan Syndrome	13.1%
96	Erythema Induratum	12.9%
97	Pyoderma Gangrenosum	12.7%
98	Poland Syndrome	12.6%
99	Keloid	12.5%
100	Discitis	12.4%
101	Ainhum	12.2%
102	Bunion	12.2%
103	Dysostoses	12.2%
104	Fibrodysplasia Ossificans Progressiva	12.2%
105	Myoglobinuria	12.2%
106	Myositis Ossificans	12.2%
107	Spinal Stenosis	12.2%
108	Spondylosis	12.2%
109	Tenosynovitis	12.2%
110	Intervertebral Disc Degeneration	12.2%
111	Sacroiliitis	12.2%
112	Bone Diseases, Endocrine	11.5%
113	Goldenhar Syndrome	11.4%
114	Bone Diseases, Infectious	11.1%
115	Bone neoplasms	11.1%
116	Compartment syndromes	11.1%
117	Maxillary Diseases	11.1%
118	Osteopenia	11.1%
119	Tendinitis	11.1%
120	Tendinopathy	11.1%
121	Pectus carinatum	11.1%
122	Bone Resorption	10.9%
123	Hemarthrosis	10.9%
124	Myositis	10.9%
125	Limb Deformities, Congenital	10.9%
126	Isaacs syndrome	10.9%
127	Craniofacial Abnormalities	10.9%
128	Aseptic Necrosis of Bone	10.9%
129	Myotonic Disorders	10.9%
130	Chondrodysplasia Punctata	10.8%
131	Enchondromatosis	10.8%
132	Lordosis	10.8%
133	Osteosclerosis	10.8%
134	Spondylolysis	10.8%
135	kyphosis	10.8%
136	Kashin-Beck Disease	10.8%
137	Acne Vulgaris	10.7%
138	Contact Dermatitis	10.7%
139	Eczema	10.7%
140	Erythema Multiforme	10.7%
141	Intertrigo	10.7%
142	Nail-Patella Syndrome	10.7%
143	Neurodermatitis	10.7%
144	Rhinophyma	10.7%
145	Perioral Dermatitis	10.7%
146	Acne	10.7%
147	Dermatitis, Phototoxic	10.3%
148	Pityriasis Lichenoides et Varioliformis Acuta	10.3%
149	Pityriasis Lichenoides	10.3%
150	Phototoxicity	10.3%
151	Lupus Nephritis	10.3%
152	Melorheostosis	10.2%
153	Osteopetrosis	10.2%
154	Spondylolisthesis	10.2%
155	Tuberculosis, Spinal	10.2%
156	Breast Diseases	10%
157	Dermatitis	10%
158	Exanthema	10%
159	Facial Dermatoses	10%
160	Hair Diseases	10%
161	Hand Dermatoses	10%
162	keratoacanthoma	10%
163	Keratosis	10%
164	Nail Diseases	10%
165	Photosensitivity Disorders	10%
166	Prurigo	10%
167	Pyoderma	10%
168	Rosacea	10%
169	Sebaceous Gland Diseases	10%
170	Skin Diseases, Vesiculobullous	10%
171	Skin Ulcer	10%
172	Sweat Gland Diseases	10%
173	Skin Diseases, Papulosquamous	10%
174	Skin Diseases, Vascular	10%
175	Acneiform Eruptions	10%
176	Ocular Rosacea	10%
177	Subcorneal pustular dermatosis	10%
178	Erythematotelangiectatic Rosacea	10%
179	Papulopustular Rosacea	10%
180	Chronic Actinic Dermatitis	10%
181	Mandibulofacial Dysostosis	9.9%
182	Foot Ulcer	9.7%
183	Prognathism	9.6%
184	Congenital Hypothyroidism	9.5%
185	Arthritis, Infectious	9.1%
186	Multiple Epiphyseal Dysplasia	9.1%
187	Osteochondrodysplasias	9.1%
188	Jaw Abnormalities	9.1%
189	Homocystinuria	9%
190	Antley-Bixler Syndrome Phenotype	9%
191	Anterior Compartment Syndrome	8.9%
192	Osteomyelitis	8.9%
193	Osteoporosis	8.9%
194	Periostitis	8.9%
195	Enthesopathy	8.9%
196	Bone Demineralization, Pathologic	8.9%
197	Post-Traumatic Osteoporosis	8.9%
198	Arthritis, Experimental	8.9%
199	Abdominal Compartment Syndrome	8.9%
200	Dermatitis, Atopic	8.9%
201	Epidermolysis Bullosa	8.9%
202	Alveolar Bone Loss	8.8%
203	Amelia	8.8%
204	Arachnodactyly	8.8%
205	Ectromelia	8.8%
206	Femur Head Necrosis	8.8%
207	Hemimelia	8.8%
208	Phocomelia	8.8%
209	Sirenomelia	8.8%
210	Polymyositis	8.8%
211	Polydactyly	8.8%
212	Brachydactyly	8.8%
213	Plagiocephaly	8.8%
214	Lower Extremity Deformities, Congenital	8.8%
215	Upper Extremity Deformities, Congenital	8.8%
216	Osteolysis	8.8%
217	Dermatitis, Irritant	8.8%
218	Acne Conglobata	8.8%
219	Osteochondritis	8.7%
220	Medial Tibial Stress Syndrome	8.7%
221	Dermatitis Herpetiformis	8.6%
222	Mitochondrial Myopathies	8.6%
223	Dermatitis, Photoallergic	8.5%
224	Muscle Cramp	8.5%
225	Eosinophilia-Myalgia Syndrome	8.5%
226	Gastroschisis	8.5%
227	Acrodermatitis	8.5%
228	Sebaceous Gland Neoplasms	8.5%
229	Porokeratosis	8.5%
230	Gianotti-Crosti Syndrome	8.5%
231	Keratoderma, Palmoplantar	8.5%
232	Muscle Rigidity	8.4%
233	Muscle Spasticity	8.4%
234	Cogwheel Rigidity	8.4%
235	CREST Syndrome	8.4%
236	Nuchal Rigidity	8.4%
237	Xeroderma Pigmentosum	8.3%
238	Osteoporosis, Postmenopausal	7.9%
239	Palatal Neoplasms	7.8%
240	Diaper Rash	7.8%
241	Micrognathism	7.8%
242	Pierre Robin Syndrome	7.8%
243	Urticaria Pigmentosa	7.6%
244	Dwarfism	7.5%
245	Chronic Fatigue Syndrome	7.4%
246	Skin Abnormalities	7.4%
247	Skin Diseases, Infectious	7.4%
248	Skin Neoplasms	7.4%
249	Pigmentation Disorders	7.4%
250	Anhidrosis	7.3%
251	Cholesteatoma	7.3%
252	Pressure Ulcer	7.3%
253	Folliculitis	7.3%
254	Foot Dermatoses	7.3%
255	Gynecomastia	7.3%
256	Hypertrichosis	7.3%
257	Hypohidrosis	7.3%
258	Hypotrichosis	7.3%
259	Leg Ulcer	7.3%
260	Miliaria	7.3%
261	Parakeratosis	7.3%
262	Parapsoriasis	7.3%
263	Pityriasis	7.3%
264	Psoriasis	7.3%
265	Sweet Syndrome	7.3%
266	Hidradenitis	7.3%
267	Onycholysis	7.3%
268	Miliaria Rubra	7.3%
269	Hyperpigmentation	7.3%
270	Lichenoid Eruptions	7.3%
271	Chloracne	7.3%
272	Lipomatosis	7.3%
273	Pruritus	7.3%
274	Erythema	7.3%
275	Necrolytic Migratory Erythema	7.3%
276	Cutaneous Fistula	7.3%
277	Nephrogenic Fibrosing Dermopathy	7.3%
278	Nephrogenic Systemic Fibrosis	7.3%
279	Hip Dislocation	7.2%
280	Dermatitis, Occupational	7.2%
281	Shoulder Dislocation	7.2%
282	Hip Dysplasia	7.2%
283	Mucopolysaccharidosis III	7.2%
284	Rubinstein-Taybi Syndrome	7.2%
285	Myotonic Dystrophy	7.2%
286	Giant Cell Epulis	7.1%
287	Muscle Weakness	7.1%
288	Muscular Dystrophy	7.1%
289	Orbital Myositis	7.1%
290	Xeroderma	7.1%
291	Musculoskeletal Pain	7%
292	Pyomyositis	7%
293	Familial Periodic Paralysis	7%
294	Acromegaly	7%
295	Joint Tuberculosis	7%
296	Tuberculosis, Osteoarticular	7%
297	Bone Tuberculosis	7%
298	Dermatitis, Allergic Contact	6.9%
299	Arthralgia	6.9%
300	Polyarthralgia	6.9%
301	Retrognathia	6.9%
302	Papillon-Lefevre Disease	6.9%
303	Erythema Infectiosum	6.4%
304	Exanthema Subitum	6.4%
305	Toxic Epidermal Necrolysis	6.3%
306	Stevens-Johnson Syndrome	6.3%
307	Erythema Nodosum	6.3%
308	Welander Distal Myopathy	6.2%
309	Mastoiditis	6.2%
310	Petrositis	6.2%
311	Lichen Planus	6%
312	Melanosis	6%
313	Chloasma	6%
314	Pityriasis Rosea	6%
315	Pityriasis Rubra Pilaris	6%
316	Vitiligo	6%
317	Lichen Nitidus	6%
318	Tinea Capitis	6%
319	Onychomycosis	6%
320	Ectodermal Dysplasia	5.9%
321	Aplasia Cutis Congenita	5.9%
322	Eosinophilic Granuloma	5.9%
323	Myalgia	5.9%
324	Maxillofacial Abnormalities	5.8%
325	Hyperkeratosis, Epidermolytic	5.8%
326	Basal Cell Nevus Syndrome	5.8%
327	Myotonia Congenita	5.8%
328	Rickets	5.8%
329	Microcephaly	5.7%
330	Macrocephaly	5.7%
331	Hypokalemic periodic paralysis	5.7%
332	Mastocytosis	5.7%
333	Shoulder Pain	5.7%
334	Cleft Palate	5.6%
335	Acantholysis	5.5%
336	Breast Cyst	5.5%
337	Actinic keratosis	5.5%
338	Pemphigoid, Benign Mucous Membrane	5.5%
339	Pemphigus	5.5%
340	Piedra	5.5%
341	Sunburn	5.5%
342	Acanthosis Nigricans	5.4%
343	Alopecia Areata	5.4%
344	Lentigo	5.4%
345	Ecthyma	5.4%
346	Argyria	5.4%
347	Hirsutism	5.4%
348	Lactation Disorder	5.4%
349	Mastitis	5.4%
350	Urticaria	5.4%
351	Adiposis Dolorosa	5.3%
352	Pruritus Vulvae	5.3%
353	Mastocytoma	5.3%
354	Pruritus Ani	5.3%
355	Muscular Dystrophy, Duchenne	5.2%
356	Osteomalacia	5.1%
357	Porencephaly	5.1%
358	Mucopolysaccharidosis II	5%
359	Pseudohypoparathyroidism	4.9%
360	Ichthyosis, X-Linked	4.9%
361	Mitochondrial Encephalomyopathies	4.9%
362	Hidradenitis Suppurativa	4.9%
363	Sjogren-Larsson Syndrome	4.9%
364	Behcet Syndrome	4.7%
365	Lupus Vasculitis, Central Nervous System	4.6%
366	Tinea Pedis	4.6%
367	Alopecia	4.5%
368	Sweating, Gustatory	4.5%
369	Androgenetic Alopecia	4.5%
370	Auriculotemporal Syndrome	4.5%
371	Lice Infestations	4.4%
372	Varicose Ulcer	4.4%
373	Breast Neoplasms, Male	4.4%
374	Triple Negative Breast Neoplasms	4.4%
375	Galactorrhea	4.4%
376	Dermatomycoses	4.3%
377	Mucocutaneous Lymph Node Syndrome	4.3%
378	Skin Diseases, Bacterial	4.3%
379	Drug Eruptions	4.2%
380	Lipodystrophy	4.2%
381	Livedo Reticularis	4.2%
382	Malignant Atrophic Papulosis	4.2%
383	Albinism	4.2%
384	Polyarteritis Nodosa	4.2%
385	Takayasu Arteritis	4.2%
386	Erythema Chronicum Migrans	4.1%
387	Radicular Cyst	4.1%
388	Lichen Planus, Oral	4%
389	Cockayne Syndrome	3.9%
390	Holoprosencephaly	3.8%
391	Mycetoma	3.7%
392	Larva Migrans	3.5%
393	Leishmaniasis	3.5%
394	Molluscum Contagiosum	3.5%
395	Porphyrias, Hepatic	3.5%
396	Angioedema	3.5%
397	Onchocerciasis	3.5%
398	Nose Neoplasms	3.5%
399	Chromoblastomycosis	3.5%
400	Dermatophytosis	3.5%
401	Sporotrichosis	3.5%
402	Tinea	3.5%
403	Tinea Versicolor	3.5%
404	Trichophytosis	3.5%
405	Hyalohyphomycosis	3.5%
406	Acute Generalized Exanthematous Pustulosis	3.4%
407	Renal Osteodystrophy	3.3%
408	Renal rickets	3.3%
409	Leishmaniasis, Cutaneous	3.1%
410	Eczema Herpeticum	3.1%
411	Fusariosis	3.1%
412	Warts	3%
413	Hereditary Angioedema Type III	2.9%
414	Hereditary Angioedema Types I and II	2.9%
415	Candidiasis, Chronic Mucocutaneous	2.9%
416	Cutaneous Candidiasis	2.9%
417	Erysipelas	2.9%
418	Serum Sickness	2.9%
419	Staphylococcal Skin Infections	2.9%
420	Variegate Porphyria	2.9%
421	Acute intermittent porphyria	2.9%
422	Porphyria Cutanea Tarda	2.9%
423	Erythrasma	2.8%
424	Carcinoma, Lobular	2.8%
425	MELAS Syndrome	2.7%
426	Angioedemas, Hereditary	2.6%
427	Epidermodysplasia Verruciformis	2.6%
428	Herpes Labialis	2.6%
429	Diabetic Foot	2.6%
430	Staphylococcal Scalded Skin Syndrome	2.5%
431	Kearns-Sayre syndrome	2.5%
432	Peutz-Jeghers Syndrome	2.5%
433	carbuncle	2.4%
434	Giant Cell Arteritis	2.2%
435	Temporal Arteritis	2.2%
436	Condylomata Acuminata	2.2%
437	Furunculosis	2.2%
438	furuncle	2.2%
439	Impetigo	2.2%
440	Blastomycosis	2.1%
441	HIV-Associated Lipodystrophy Syndrome	2.1%
442	Familial Hypophosphatemic Rickets	2%
443	Rhinoscleroma	1.9%
444	Menkes Kinky Hair Syndrome	1.7%

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