MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hydranencephaly

(UMLS:C0020225)

Definition:: A congenital condition where the greater portions of the cerebral hemispheres and CORPUS STRIATUM are replaced by CSF and glial tissue. The meninges and the skull are well formed, which is consistent with earlier normal embryogenesis of the telencephalon. Bilateral occlusions of the internal carotid arteries in utero is a potential mechanism. Clinical features include intact brainstem reflexes without evidence of higher cortical activity. (Menkes, Textbook of Child Neurology, 5th ed, p307)
UMLS ID:: C0020225
MeSH ID:: D006832

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.450

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.666.450

Synonym(s)

Hydranencephaly

Congenital absence of cerebral hemispheres

Hydrancephaly

hydranencephaly

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Paroxetine	FAERS: 2		US FAERS
2	Fluoxetine	FAERS: 1		US FAERS
3	Warfarin	FAERS: 1		US FAERS
4	Cocaine		2276252	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Neural Tube Defects	44.8%
2	Tethered Cord Syndrome	44.8%
3	Iniencephaly	44.8%
4	Craniorachischisis	44.8%
5	Exencephaly	44.8%
6	Septo-Optic Dysplasia	44.8%
7	Cortical Dysplasia	44.8%
8	Malformations of Cortical Development	44.8%
9	Dandy-Walker Syndrome	34.8%
10	Dural Arteriovenous Fistula	34.5%
11	Anencephaly	34.2%
12	Meningomyelocele	32.8%
13	Spina Bifida	32.8%
14	Central Nervous System Cysts	32.8%
15	Classical Lissencephalies and Subcortical Band Heterotopias	30.2%
16	Holoprosencephaly	28.1%
17	Aicardi's syndrome	27.7%
18	Dermal Sinus	27%
19	Spina Bifida Cystica	27%
20	Spina Bifida Occulta	27%
21	Lissencephaly	27%
22	Polymicrogyria	27%
23	Pachygyria	27%
24	Schizencephaly	27%
25	Periventricular Nodular Heterotopia	27%
26	Meningocele	26.2%
27	Encephalocele	26.2%
28	Charcot-Marie-Tooth Disease	24.2%
29	Microcephaly	22.9%
30	Macrocephaly	22.9%
31	Porencephaly	21.9%
32	Abnormalities, Drug-Induced	20.9%
33	Situs Inversus	20.9%
34	Smith-Magenis syndrome	20.5%
35	Alstrom Syndrome	20.2%
36	Beckwith-Wiedemann Syndrome	18.9%
37	Wolf-Hirschhorn Syndrome	18.9%
38	Cri-du-Chat Syndrome	18.4%
39	Down Syndrome	18.4%
40	Trisomy 21	18.4%
41	Tuberous Sclerosis	16.9%
42	Eye Abnormalities	16.4%
43	Cardiovascular Abnormalities	16.4%
44	Skin Abnormalities	15.8%
45	Lymphatic Abnormalities	15.8%
46	Congenital Microtia	15.8%
47	Prader-Willi Syndrome	15.7%
48	Refsum Disease	15.5%
49	Rubinstein-Taybi Syndrome	15.5%
50	Congenital diaphragmatic hernia	15.4%
51	Cranial nerve diseases	14.6%
52	Demyelinating Diseases	14.6%
53	Demyelination	14.6%
54	Neuromuscular Diseases	14.6%
55	Chronobiology Disorders	14.6%
56	Multiple System Atrophy	14.1%
57	Motor Neuron Disease	14%
58	Prune Belly Syndrome	13.6%
59	Twins, Conjoined	13.6%
60	Mobius Syndrome	13.6%
61	Waardenburg Syndrome	13.6%
62	Ectodermal Dysplasia	13.5%
63	Aplasia Cutis Congenita	13.5%
64	Urogenital Abnormalities	13%
65	Stiff-Person Syndrome	12.6%
66	CHARGE Syndrome	12.3%
67	Meningoencephalitis	12.2%
68	Genetic Diseases, Inborn	12.2%
69	Spinal Muscular Atrophy	12.2%
70	Progressive Muscular Atrophy	12.2%
71	Encephalomyelitis	12.1%
72	Prion Diseases	12.1%
73	Autonomic Dysreflexia	12.1%
74	Complex Regional Pain Syndromes	12.1%
75	Polyradiculoneuropathy	12%
76	Polyradiculoneuritis	12%
77	Maxillofacial Abnormalities	11.9%
78	Parkinson Disease	11.8%
79	Dextrocardia	11.7%
80	Williams Syndrome	11.6%
81	Ocular Motility Disorders	11.6%
82	Cyclophoria	11.6%
83	Amyotrophic Lateral Sclerosis	11.5%
84	Trauma, Nervous System	11.3%
85	Striatonigral Degeneration	11.3%
86	Restless Legs Syndrome	11.3%
87	Ophthalmoplegic Migraine	11.2%
88	Dystonia Musculorum Deformans	11.1%
89	Marchiafava-Bignami Disease	11.1%
90	Nervous System Neoplasms	10.9%
91	Neurologic Manifestations	10.9%
92	Neurotoxicity Syndromes	10.9%
93	Cockayne Syndrome	10.9%
94	Kartagener Syndrome	10.8%
95	Lewy Body Disease	10.7%
96	Guillain-Barre Syndrome	10.7%
97	Subacute Combined Degeneration	10.7%
98	Causalgia	10.7%
99	Fragile X Syndrome	10.5%
100	Anophthalmos	10.3%
101	Anus, Imperforate	10.3%
102	Microphthalmos	10.3%
103	Nail-Patella Syndrome	10.3%
104	Limb Deformities, Congenital	10.3%
105	Craniofacial Abnormalities	10.3%
106	Myasthenic Syndromes, Congenital	10.3%
107	Anorectal Malformations	10.3%
108	Xeroderma	10.2%
109	Marfan Syndrome	10.2%
110	Bloom Syndrome	10.2%
111	Myelitis	10.2%
112	Progressive bulbar palsy	10.2%
113	Bulbar palsy	10.2%
114	Leukoencephalitis, Acute Hemorrhagic	10.1%
115	Pneumocephalus	10.1%
116	Poliomyelitis	10.1%
117	Lafora Disease	10%
118	Unverricht-Lundborg Syndrome	10%
119	Spinal Cord Injuries	10%
120	Miller Fisher Syndrome	10%
121	Progressive supranuclear palsy	9.9%
122	Peripheral Nerve Injuries	9.7%
123	Shy-Drager Syndrome	9.7%
124	Myasthenia Gravis	9.6%
125	Asterixis	9.6%
126	Ballismus	9.6%
127	POEMS Syndrome	9.4%
128	Epidural Abscess	9.4%
129	Olfactory Nerve Injuries	9.4%
130	MPTP Poisoning	9.3%
131	Brain Diseases	9.3%
132	Dysautonomia	9.3%
133	Meningitis	9.3%
134	Movement Disorders	9.3%
135	Pachymeningitis	9.3%
136	Spinal Cord Diseases	9.3%
137	Vagus Nerve Disorder	9.3%
138	Glossopharyngeal Neuralgia	9.3%
139	Abducens Nerve Diseases	9.3%
140	Heavy Metal Poisoning, Nervous System	9.3%
141	Neuromuscular Junction Diseases	9.3%
142	Tauopathies	9.3%
143	Trochlear Nerve Diseases	9.3%
144	Peripheral Nervous System Diseases	9.3%
145	Myelitis, Transverse	9.3%
146	Reflex Sympathetic Dystrophy	9.2%
147	Subdural Effusion	9.2%
148	Parkinsonian Disorders	9.2%
149	Nocturnal Myoclonus Syndrome	9.2%
150	Encephalomyelitis, Acute Disseminated	9.1%
151	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.1%
152	Fetal Diseases	9.1%
153	Huntington Disease	9%
154	Scimitar Syndrome	9%
155	Canavan Disease	8.9%
156	Alexander Disease	8.9%
157	Neuromyelitis Optica	8.9%
158	Polycystic Kidney Diseases	8.9%
159	Neuroleptic Malignant Syndrome	8.8%
160	Myelinolysis, Central Pontine	8.8%
161	Sleep Wake Disorders	8.8%
162	Myotonic Dystrophy	8.7%
163	Abnormalities, Radiation-Induced	8.6%
164	Opsoclonus-Myoclonus Syndrome	8.6%
165	Craniosynostosis	8.5%
166	Syndactyly	8.5%
167	Brachycephaly	8.5%
168	Ataxia Telangiectasia	8.5%
169	Lambert-Eaton Myasthenic Syndrome	8.4%
170	Myotonia Congenita	8.4%
171	Blepharophimosis	8.3%
172	Chronic Fatigue Syndrome	8.3%
173	Laryngostenosis	8.3%
174	Meige Syndrome	8.3%
175	Mouth Abnormalities	8.3%
176	Brachial Plexus Neuritis	8.3%
177	Neuralgic Amyotrophy	8.3%
178	Cerebral Ventriculitis	8.3%
179	Epilepsy, Post-Traumatic	8.2%
180	Friedreich Ataxia	8.2%
181	Sleep Disorders, Circadian Rhythm	8.2%
182	Esophageal Atresia	8.2%
183	Intestinal Atresia	8.2%
184	Horseshoe Kidney	8.2%
185	Pectus excavatum	8.2%
186	Klippel-Feil Syndrome	8.2%
187	Gastroschisis	8.2%
188	Synostosis	8.2%
189	Acrodermatitis	8.1%
190	Lymphangiectasis, Intestinal	8.1%
191	Gianotti-Crosti Syndrome	8.1%
192	Brain Injuries	8.1%
193	Facial Nerve Injuries	8.1%
194	Acrocephalosyndactylia	8.1%
195	Brain Neoplasms	8.1%
196	Multiple Sclerosis	8.1%
197	Spinal Cord Neoplasms	8.1%
198	Dyskinesia, Drug-Induced	8.1%
199	Leukoencephalopathy, Progressive Multifocal	8%
200	Hepatolenticular Degeneration	8%
201	Retinal Dysplasia	7.9%
202	Botulism	7.9%
203	Tarsal Tunnel Syndrome	7.9%
204	Cauda Equina Syndrome	7.9%
205	Posterior Leukoencephalopathy Syndrome	7.9%
206	Posterior reversible encephalopathy syndrome	7.9%
207	Aniridia	7.8%
208	Primary Ciliary Dyskinesia	7.8%
209	Leukomalacia, Periventricular	7.8%
210	Epidermolysis Bullosa	7.7%
211	Cerebellar Neoplasms	7.6%
212	Limbic Encephalitis	7.6%
213	Amelia	7.6%
214	Arachnodactyly	7.6%
215	Ectopia Cordis	7.6%
216	Ectromelia	7.6%
217	Hemimelia	7.6%
218	Noonan Syndrome	7.6%
219	Phocomelia	7.6%
220	Sirenomelia	7.6%
221	Polydactyly	7.6%
222	Brachydactyly	7.6%
223	Plagiocephaly	7.6%
224	Lower Extremity Deformities, Congenital	7.6%
225	Upper Extremity Deformities, Congenital	7.6%
226	Single umbilical artery	7.6%
227	Muscular Dystrophy	7.5%
228	Scrapie	7.5%
229	Central Cord Syndrome	7.5%
230	Congenital nystagmus	7.5%
231	Myoclonic Epilepsy	7.4%
232	Epilepsy, Temporal Lobe	7.4%
233	Epilepsy, Rolandic	7.4%
234	Benign Rolandic Epilepsy	7.4%
235	Lupus Vasculitis, Central Nervous System	7.4%
236	Smith-Lemli-Opitz Syndrome	7.4%
237	Presenile dementia	7.4%
238	Senile dementia	7.4%
239	Meningitis, Bacterial	7.4%
240	Meningitis, Fungal	7.4%
241	Turner Syndrome	7.4%
242	Chorea	7.3%
243	Acrodynia	7.3%
244	Horner Syndrome	7.3%
245	Central Nervous System Infection	7.3%
246	Myopathy	7.3%
247	Optic Neuropathy	7.3%
248	Ichthyosis, X-Linked	7.2%
249	Toxoplasmosis, Congenital	7.1%
250	Cystic Fibrosis	7.1%
251	Myasthenia Gravis, Autoimmune, Experimental	7%
252	Facial Nerve Diseases	7%
253	Craniocerebral Trauma	7%
254	Parasomnia	7%
255	Dyssomnias	7%
256	Juvenile Myoclonic Epilepsy	7%
257	Myoclonic Epilepsies, Progressive	7%
258	Poland Syndrome	7%
259	Dementia, Vascular	7%
260	Abdominal Cramps	7%
261	Amniotic Band Syndrome	7%
262	Arthrogryposis	7%
263	Asphyxia Neonatorum	7%
264	Choanal Atresia	7%
265	Infant, Premature, Diseases	7%
266	Tracheobronchomegaly	7%
267	Infantile Colic	7%
268	Laryngocele	7%
269	Brain Hemorrhage, Traumatic	7%
270	Jaw Abnormalities	6.9%
271	Cleft Palate	6.9%
272	Rett Syndrome	6.9%
273	Muscular Dystrophy, Duchenne	6.9%
274	Vestibulocochlear Nerve Diseases	6.9%
275	Choledochal Cyst	6.9%
276	Decerebrate State	6.9%
277	Hemiparesis	6.9%
278	Hermaphroditism	6.9%
279	Meningism	6.9%
280	Paresis	6.9%
281	Seizures	6.9%
282	Sensation Disorders	6.9%
283	Disorders of Sex Development	6.9%
284	Central Nervous System Neoplasms	6.9%
285	Complex partial seizures	6.9%
286	Monoparesis	6.9%
287	Neurogenic Inflammation	6.9%
288	Gait Disorders, Neurologic	6.9%
289	Neuromuscular Manifestations	6.9%
290	Adrenoleukodystrophy	6.9%
291	Brain Death	6.8%
292	Coma, Post-Head Injury	6.8%
293	Sweating, Gustatory	6.8%
294	Auriculotemporal Syndrome	6.8%
295	Akinetic Mutism	6.8%
296	Anoxic Encephalopathy	6.8%
297	Arachnoiditis	6.8%
298	Basal Ganglia Diseases	6.8%
299	Brain Damage, Chronic	6.8%
300	Cerebellar Diseases	6.8%
301	Cryptorchidism	6.8%
302	Encephalitis	6.8%
303	Encephalomalacia	6.8%
304	Epilepsy	6.8%
305	Hydrocephalus	6.8%
306	Congenital Hydrocephalus	6.8%
307	Hypothalamic Diseases	6.8%
308	Aseptic Meningitis	6.8%
309	Neuritis	6.8%
310	Polyneuritis	6.8%
311	Radiculitis	6.8%
312	Syringomyelia	6.8%
313	Thalamic Diseases	6.8%
314	Intracranial Hypertension	6.8%
315	Polyneuropathy	6.8%
316	Mononeuritis	6.8%
317	Aura	6.8%
318	Leukoencephalopathy	6.8%
319	Essential Tremor	6.8%
320	Neuroaxonal Dystrophies	6.8%
321	Familial Tremor	6.8%
322	Headache Disorders	6.8%
323	Mononeuropathies	6.8%
324	Intracranial Hypotension	6.8%
325	Brachial Plexus Neuropathies	6.8%
326	Radiculopathy	6.8%
327	Mononeuropathy Multiplex	6.8%
328	Nerve Root Compression	6.8%
329	Hypospadias	6.8%
330	Brain Edema	6.8%
331	Brain Hypoxia	6.8%
332	Aqueductal Stenosis	6.8%
333	Pneumorrhachis	6.8%
334	Writer's Cramp	6.8%
335	Akathisia, Drug-Induced	6.8%
336	Brain Abscess	6.8%
337	Ophthalmoplegia	6.8%
338	External Ophthalmoplegia	6.8%
339	Creutzfeldt-Jakob disease	6.7%
340	Basal Ganglia Cerebrovascular Disease	6.7%
341	Brain Injuries, Diffuse	6.6%
342	Traumatic Brain Injury	6.6%
343	Cerebellar Ataxia	6.6%
344	Supratentorial Neoplasms	6.6%
345	Torticollis	6.6%
346	Multiple Sclerosis, Chronic Progressive	6.6%
347	Multiple Sclerosis, Relapsing-Remitting	6.6%
348	Amyloid Neuropathies, Familial	6.6%
349	Polycystic Kidney, Autosomal Dominant	6.5%
350	Tuberculosis, Meningeal	6.5%
351	Klinefelter Syndrome	6.3%
352	Carpal Tunnel Syndrome	6.3%
353	Vascular Headaches	6.3%
354	Vasculitis, Central Nervous System	6.3%
355	neurofibroma	6.3%
356	Hypoxia-Ischemia, Brain	6.3%
357	Sciatica	6.2%
358	Jet Lag Syndrome	6.2%
359	Tardive Dyskinesia	6.2%
360	Persistent Vegetative State	6.2%
361	Zellweger Syndrome	6.2%
362	Carotid Artery Injuries	6.2%
363	Amblyopia	6.2%
364	Paraneoplastic Cerebellar Degeneration	6.1%
365	Cerebrospinal Fluid Otorrhea	6.1%
366	Cerebrospinal Fluid Rhinorrhea	6.1%
367	Neuritis, Autoimmune, Experimental	6.1%
368	Gait Ataxia	6.1%
369	Aortic coarctation	6%
370	Cor Triatriatum	6%
371	Coronary Vessel Anomalies	6%
372	Dental Enamel Hypoplasia	6%
373	Patent ductus arteriosus	6%
374	Ebstein Anomaly	6%
375	Heart Septal Defects	6%
376	Hypodontia	6%
377	Macrostomia	6%
378	Microstomia	6%
379	Tetralogy of Fallot	6%
380	Transposition of Great Vessels	6%
381	Hypoplastic Left Heart Syndrome	6%
382	May-Thurner Syndrome	6%
383	Craniofacial Dysostosis	6%
384	Pseudoxanthoma Elasticum	6%
385	Wolff-Parkinson-White Syndrome	6%
386	Meconium Aspiration Syndrome	5.9%
387	Laryngomalacia	5.9%
388	Cubital Tunnel Syndrome	5.9%
389	Diffuse Axonal Injury	5.9%
390	Neuronal Ceroid-Lipofuscinoses	5.9%
391	Brain Stem Neoplasms	5.9%
392	Pectus carinatum	5.9%
393	Vocal Cord Paralysis	5.9%
394	Micrognathism	5.8%
395	Pierre Robin Syndrome	5.8%
396	Alice in Wonderland Syndrome	5.8%
397	Sjogren-Larsson Syndrome	5.8%
398	Bladder Exstrophy	5.8%
399	Epispadias	5.8%
400	Pituitary Adenoma	5.8%
401	Pituitary Neoplasms	5.8%
402	Multicystic Dysplastic Kidney	5.8%
403	Duane Retraction Syndrome	5.7%
404	Brain Concussion	5.7%
405	Pupil Disorders	5.7%
406	Neurobehavioral Manifestations	5.7%
407	Menkes Kinky Hair Syndrome	5.7%
408	Optic Atrophy, Hereditary, Leber	5.7%
409	Welander Distal Myopathy	5.6%
410	Antley-Bixler Syndrome Phenotype	5.6%
411	Cerebral Palsy	5.6%
412	Epilepsies, Partial	5.6%
413	Epilepsy, Generalized	5.6%
414	Pseudotumor Cerebri	5.6%
415	Sciatic Neuropathy	5.6%
416	Hypertensive Encephalopathy	5.6%
417	Ulnar Neuropathies	5.6%
418	Lesion of Sciatic Nerve	5.6%
419	Simple Partial Seizures	5.6%
420	Epilepsy, Reflex	5.6%
421	Ulnar Neuritis	5.6%
422	Radial nerve compression	5.6%
423	Radial Tunnel Syndrome	5.6%
424	Peroneal Neuropathies	5.6%
425	Radial Neuropathy	5.6%
426	Median Neuropathy	5.6%
427	Sciatic Nerve Palsy	5.6%
428	Femoral Neuropathy	5.6%
429	Tibial Neuropathy	5.6%
430	Ulnar Nerve Palsy	5.6%
431	Postural Orthostatic Tachycardia Syndrome	5.6%
432	Radial nerve palsy	5.6%
433	Headache Disorders, Primary	5.6%
434	Headache Disorders, Secondary	5.6%
435	Medication overuse headache	5.6%
436	Kallmann Syndrome	5.6%
437	Paraneoplastic Encephalomyelitis	5.6%
438	Choroid Plexus Papilloma	5.5%
439	Hyperkeratosis, Epidermolytic	5.5%
440	Uveomeningoencephalitic Syndrome	5.5%
441	Neoplastic Syndromes, Hereditary	5.5%
442	Sturge-Weber Syndrome	5.4%
443	Vertigo	5.4%
444	Alcohol-Induced Disorders, Nervous System	5.4%
445	Xeroderma Pigmentosum	5.4%
446	Basal Ganglia Hemorrhage	5.4%
447	Toxoplasmosis, Cerebral	5.3%
448	Optic Nerve Glioma	5.3%
449	Meningitis, Cryptococcal	5.2%
450	Meningitis, Listeria	5.2%
451	Retrognathia	5.2%
452	Akathisia	5.2%
453	Restlessness	5.2%
454	Psychomotor Agitation	5.2%
455	Meningitis, Haemophilus	5.2%
456	Meningitis, Pneumococcal	5.2%
457	Frontotemporal dementia	5.2%
458	Anemia, Neonatal	5.2%
459	Brain Diseases, Metabolic	5.2%
460	Cerebrovascular Disorders	5.2%
461	Multiple Epiphyseal Dysplasia	5.2%
462	Myositis	5.2%
463	Optic Atrophy	5.2%
464	Optic Neuritis	5.2%
465	Osteochondrodysplasias	5.2%
466	Papilledema	5.2%
467	Pelger-Huet Anomaly	5.2%
468	Persistent Fetal Circulation Syndrome	5.2%
469	Strabismus	5.2%
470	Tolosa-Hunt Syndrome	5.2%
471	Werner Syndrome	5.2%
472	Cerebrovascular Insufficiency	5.2%
473	Isaacs syndrome	5.2%
474	Arsenic Poisoning	5.2%
475	Dementia	5.2%
476	Myotonic Disorders	5.2%
477	Central Nervous System Fungal Infections	5.2%
478	Conus Medullaris Syndrome	5.2%
479	Spinal Cord Vascular Diseases	5.2%
480	Umbilical hernia	5.1%
481	Diabetic Neuropathies	5.1%
482	Facial Injuries	5.1%
483	Facial Neuralgia	5.1%
484	Diabetic Amyotrophy	5.1%
485	Diabetic Autonomic Neuropathy	5.1%
486	Sleep Talking	5.1%
487	Manganese Poisoning	5.1%
488	Sleep Disorders, Intrinsic	5.1%
489	Orthostatic intolerance	5.1%
490	Putaminal Hemorrhage	5.1%
491	Familial Periodic Paralysis	5.1%
492	Anosmia	5%
493	Ataxia	5%
494	Athetosis	5%
495	Catalepsy	5%
496	Dystonia	5%
497	Hemiplegia	5%
498	Locked-In Syndrome	5%
499	Meningeal Neoplasms	5%
500	Muscle Hypertonia	5%
501	Muscle hypotonia	5%
502	Myoclonus	5%
503	Myotonia	5%
504	Neuralgia	5%
505	Paraplegia	5%
506	Pseudobulbar Palsy	5%
507	Quadriplegia	5%
508	Spasm	5%
509	Spastic Paraplegia	5%
510	Status Epilepticus	5%
511	Taste Disorders	5%
512	Tremor	5%
513	Monoplegia	5%
514	Hypokinesia	5%
515	Paraparesis	5%
516	Bradykinesia	5%
517	Waxy flexibility	5%
518	Action Tremor	5%
519	Resting Tremor	5%
520	Dysosmia	5%
521	Quadriparesis	5%
522	Mercury Poisoning, Nervous System	5%
523	Olfaction Disorders	5%
524	Myokymia	5%
525	Lead Poisoning, Nervous System	5%
526	Vestibular Neuronitis	5%
527	Somatosensory Disorders	5%
528	Neuropathic pain	5%
529	Hyperkinesia	5%
530	Intention tremor	5%
531	Infarction, Middle Cerebral Artery	5%
532	Infarction, Anterior Cerebral Artery	5%
533	Infarction, Posterior Cerebral Artery	5%
534	Long QT Syndrome	5%
535	Platybasia	5%
536	Polyradiculopathy	5%
537	Post-Traumatic Headache	5%
538	Tension Headache	5%
539	Epilepsy, Complex Partial	5%
540	Migraine Disorders	5%
541	Tricuspid Atresia	5%
542	Abdominal Migraine	5%
543	Status Migrainosus	5%
544	Arrhythmogenic Right Ventricular Dysplasia	5%
545	Cervicogenic Headache	5%
546	Brain Diseases, Metabolic, Inborn	5%
547	Mucopolysaccharidosis II	5%
548	Gonadal Dysgenesis	5%
549	Pituitary Apoplexy	5%
550	Bronchomalacia	5%
551	Adrenogenital Syndrome	5%
552	Tracheomalacia	5%
553	Ovotesticular Disorders of Sex Development	5%
554	Alcohol Withdrawal Seizures	5%
555	Vertebral Artery Dissection	5%
556	Aortopulmonary Septal Defect	5%
557	Double Outlet Right Ventricle	5%
558	Endocardial Cushion Defects	5%
559	Myocardial bridging	5%
560	Aorticopulmonary Septal Defect	5%
561	Amnesia, Transient Global	4.9%
562	Brain Contusion	4.9%
563	Gait Apraxia	4.9%
564	Brain Infarction	4.9%
565	Subacute Sclerosing Panencephalitis	4.9%
566	Hyperandrogenism	4.9%
567	MELAS Syndrome	4.9%
568	Subarachnoid Hemorrhage, Traumatic	4.9%
569	Carotid Artery, Internal, Dissection	4.9%
570	Basal Cell Nevus Syndrome	4.8%
571	Mitochondrial Encephalomyopathies	4.7%
572	Cluster Headache	4.7%
573	Migraine with Aura	4.7%
574	Familial Hemiplegic Migraine	4.7%
575	Chronic Paroxysmal Hemicrania	4.7%
576	SUNCT Syndrome	4.7%
577	Paroxysmal Hemicrania	4.7%
578	Prognathism	4.7%
579	Voice Disorders	4.7%
580	Voice Disturbance	4.7%
581	Cerebral Infarction	4.6%
582	Brain Stem Infarctions	4.6%
583	Familial Mediterranean Fever	4.5%
584	Anemia, Sickle Cell	4.5%
585	Thalassemia	4.5%
586	Lateral Medullary Syndrome	4.5%
587	Fabry Disease	4.4%
588	Pituitary Diseases	4.4%
589	Truncus Arteriosus, Persistent	4.4%
590	Goldenhar Syndrome	4.4%
591	Galactosemias	4.3%
592	Urea Cycle Disorders, Inborn	4.3%
593	Tyrosinemias	4.3%
594	Dwarfism	4.3%
595	Hand-Arm Vibration Syndrome	4.3%
596	Thoracic Outlet Syndrome	4.3%
597	Neonatal Abstinence Syndrome	4.2%
598	Carotid Artery Diseases	4.2%
599	Brain Ischemia	4.2%
600	Esotropia	4.2%
601	Exotropia	4.2%
602	Hypotension, Orthostatic	4.2%
603	Sleep Apnea Syndromes	4.2%
604	Cerebrovascular accident	4.2%
605	Polymyositis	4.2%
606	Kluver-Bucy Syndrome	4.2%
607	Vasospasm, Intracranial	4.2%
608	Spinal Cord Ischemia	4.2%
609	Intracranial Arterial Diseases	4.2%
610	Post-Exercise Hypotension	4.2%
611	Alexia	4.2%
612	Vision Disorders	4.2%
613	Metamorphopsia	4.2%
614	Dyslexia	4.2%
615	Visual Impairment	4.2%
616	Fibromyalgia	4.2%
617	Disorders of Excessive Somnolence	4.2%
618	Sleep Initiation and Maintenance Disorders	4.2%
619	Night Terrors	4.2%
620	Somnambulism	4.2%
621	Trigeminal Nerve Disorder	4.2%
622	Optic Neuropathy, Ischemic	4.2%
623	Transient Insomnia	4.2%
624	Sleep Paralysis	4.2%
625	Chronic Insomnia	4.2%
626	Anterior Ischemic Optic Neuropathy	4.2%
627	REM Sleep Behavior Disorder	4.2%
628	Central Nervous System Bacterial Infections	4.2%
629	Hypersomnia	4.2%
630	Medial Tibial Stress Syndrome	4.2%
631	Dysgeusia	4.1%
632	Formication	4.1%
633	Hyperalgesia	4.1%
634	Hyperesthesia	4.1%
635	Hypesthesia	4.1%
636	Language Disorders	4.1%
637	Numbness	4.1%
638	Paresthesia	4.1%
639	Paraparesis, Spastic	4.1%
640	Trismus	4.1%
641	Epilepsia Partialis Continua	4.1%
642	Hypogeusia	4.1%
643	Meningeal Carcinomatosis	4.1%
644	Brown-Sequard Syndrome	4.1%
645	Lockjaw	4.1%
646	Allodynia	4.1%
647	Lead Poisoning, Nervous System, Childhood	4.1%
648	Lead Poisoning, Nervous System, Adult	4.1%
649	Ageusia	4.1%
650	Tuberculosis, Central Nervous System	4.1%
651	West Nile Fever	4.1%
652	Auditory Perceptual Disorders	4.1%
653	Hypokalemic periodic paralysis	4.1%
654	Mandibulofacial Dysostosis	4.1%
655	Facial Hemiatrophy	4.1%
656	Fetal Growth Retardation	4.1%
657	Melkersson-Rosenthal Syndrome	4.1%
658	Romano-Ward Syndrome	4.1%
659	Mitochondrial Myopathies	4.1%
660	Moyamoya Disease	4.1%
661	Albinism	4.1%
662	Anisocoria	4.1%
663	Confusion	4.1%
664	Facial paralysis	4.1%
665	Lethargy	4.1%
666	Memory Disorders	4.1%
667	Muscle Cramp	4.1%
668	Osteogenesis Imperfecta	4.1%
669	Perceptual Disorders	4.1%
670	Psychomotor Disorders	4.1%
671	Tonic Pupil	4.1%
672	Eosinophilia-Myalgia Syndrome	4.1%
673	Anhedonia	4.1%
674	Disorientation	4.1%
675	Fetal Hypoxia	4.1%
676	Facial Paresis	4.1%
677	Memory Loss	4.1%
678	Hemisensory Neglect	4.1%
679	Dysacusis	4.1%
680	Fetal Alcohol Spectrum Disorders	4.1%
681	Sleep Bruxism	4.1%
682	Neurofibrosarcoma	4.1%
683	Muscular Atrophy	4%
684	Respiratory Paralysis	4%
685	Syphilis, Congenital	4%
686	Tetany	4%
687	Giant Cell Arteritis	3.8%
688	Temporal Arteritis	3.8%
689	Empty Sella Syndrome	3.8%
690	Hyperpituitarism	3.8%
691	Hypopituitarism	3.8%
692	Hypophysitis	3.8%
693	Reflex, Abnormal	3.8%
694	Hyporeflexia	3.8%
695	Hyperreflexia	3.8%
696	Kernicterus	3.8%
697	Glycogen storage disease type II	3.8%
698	Hematoma, Subdural	3.8%
699	Hematoma, Epidural, Cranial	3.8%
700	Cerebral Arterial Diseases	3.7%
701	Vertebrobasilar Insufficiency	3.7%
702	Anterior Spinal Artery Syndrome	3.7%
703	Basilar Artery Stenosis	3.7%
704	Vertebral Artery Stenosis	3.7%
705	Sleep Apnea, Obstructive	3.7%
706	Sleep Apnea, Central	3.7%
707	Intracranial Hemorrhage, Hypertensive	3.7%
708	Transient Cerebral Ischemia	3.7%
709	Talipes	3.7%
710	Narcolepsy	3.7%
711	Trigeminal Neuralgia	3.7%
712	Kleine-Levin Syndrome	3.7%
713	Agraphia	3.7%
714	Anomia	3.7%
715	Cluttering	3.7%
716	Language Development Disorders	3.7%
717	Speech Disorders	3.7%
718	Syncope	3.7%
719	Stupor	3.7%
720	Dysgraphia	3.7%
721	Presyncope	3.7%
722	Dyslalia	3.7%
723	Homocystinuria	3.7%
724	Kearns-Sayre syndrome	3.7%
725	Leigh Disease	3.6%
726	Acoustic Neuroma	3.6%
727	Hyperprolactinemia	3.5%
728	Subclavian Steal Syndrome	3.5%
729	Pick Disease of the Brain	3.5%
730	Cataplexy	3.5%
731	Aphasia	3.5%
732	Articulation Disorders	3.5%
733	Echolalia	3.5%
734	Stuttering	3.5%
735	Dysphasia	3.5%
736	Hematoma, Subdural, Intracranial	3.5%
737	Hematoma, Subdural, Chronic	3.5%
738	Hematoma, Subdural, Acute	3.5%
739	Eye Injuries	3.5%
740	Congenital clubfoot	3.5%
741	Vertical Talus	3.5%
742	Paralysis, Obstetric	3.4%
743	Retinopathy of Prematurity	3.4%
744	Autoimmune Lymphoproliferative Syndrome	3.4%
745	Consciousness Disorders	3.4%
746	Mental Retardation	3.4%
747	Muscle Weakness	3.4%
748	Depressed Level of Consciousness	3.4%
749	Mental deficiency	3.4%
750	Intellectual Disability	3.4%
751	Bell Palsy	3.4%
752	Congenital Hyperinsulinism	3.4%
753	Orbital Myositis	3.4%
754	Amino Acid Metabolism, Inborn Errors	3.4%
755	Carbohydrate Metabolism, Inborn Errors	3.4%
756	Catatonia	3.4%
757	Chorioamnionitis	3.4%
758	Metal Metabolism, Inborn Errors	3.4%
759	Progeria	3.4%
760	Lysosomal Storage Diseases	3.4%
761	Cytochrome-c Oxidase Deficiency	3.4%
762	Peroxisomal Disorders	3.4%
763	Dysarthria	3.4%
764	Herpes Zoster Oticus	3.4%
765	Diplopia	3.4%
766	Muscle Rigidity	3.4%
767	Muscle Spasticity	3.4%
768	Scotoma	3.4%
769	Photophobia	3.4%
770	Cogwheel Rigidity	3.4%
771	Hemifacial Spasm	3.4%
772	Amaurosis	3.4%
773	Blindness	3.4%
774	Nuchal Rigidity	3.4%
775	Bronchopulmonary Dysplasia	3.4%
776	Reye Syndrome	3.4%
777	Neuroaspergillosis	3.4%
778	Pyomyositis	3.4%
779	Aphonia	3.4%
780	Angioedemas, Hereditary	3.4%
781	Sleep Deprivation	3.4%
782	Dysphonia	3.4%
783	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.3%
784	Intracranial Embolism and Thrombosis	3.3%
785	Hepatic Encephalopathy	3.3%
786	Wiskott-Aldrich Syndrome	3.3%
787	Agnosia	3.3%
788	Apraxias	3.3%
789	Hallucinations	3.3%
790	Hemianopsia	3.3%
791	Hyperacusis	3.3%
792	Tinnitus	3.3%
793	Visual Agnosia	3.3%
794	Anosognosia	3.3%
795	Wernicke-Korsakoff Syndrome	3.3%
796	Phonophobia	3.3%
797	Hearing Loss	3.3%
798	Sarcopenia	3.3%
799	Sickle Cell Trait	3.3%
800	Gaucher Disease	3.2%
801	Arteriovenous fistula	3.1%
802	Eye Burns	3%
803	Malaria, Cerebral	3%
804	Carotid Stenosis	3%
805	Intracranial Aneurysm	3%
806	Neurocysticercosis	3%
807	Amaurosis Fugax	3%
808	Blindness, Cortical	3%
809	Dyscalculia	3%
810	Intracranial Arteriosclerosis	3%
811	Cerebral Atherosclerosis	3%
812	Subarachnoid Hemorrhage	3%
813	Cerebral Arteriosclerosis	3%
814	Cerebral Hemorrhage	3%
815	Cerebral Thrombosis	3%
816	Intracranial Embolism	3%
817	Intracranial Thrombosis	3%
818	Tay-Sachs Disease	3%
819	Deafness	3%
820	Hearing Loss, Sudden	3%
821	Gerstmann Syndrome	3%
822	Hearing Loss, Bilateral	3%
823	Hearing Loss, High-Frequency	3%
824	Hearing Loss, Mixed Conductive-Sensorineural	3%
825	Prosopagnosia	3%
826	Apraxia, Ideomotor	3%
827	Charles Bonnet Syndrome	3%
828	Hearing Loss, Unilateral	3%
829	Complete Hearing Loss	3%
830	Alien Hand Syndrome	3%
831	Deaf Mutism	3%
832	Pseudorabies	2.9%
833	Myalgia	2.9%
834	Mutism	2.8%
835	Selective Mutism	2.8%
836	Acromegaly	2.8%
837	Amnesia	2.8%
838	Delirium	2.8%
839	Dissociative Amnesia	2.8%
840	Color blindness	2.8%
841	Global Amnesia	2.8%
842	Cerebral Amyloid Angiopathy	2.8%
843	Respiratory Distress Syndrome, Newborn	2.8%
844	Sinus Thrombosis, Intracranial	2.8%
845	Niemann-Pick Disease, Type C	2.8%
846	Meningioma	2.8%
847	Neurosyphilis	2.7%
848	Cutis Laxa	2.7%
849	Retinitis Pigmentosa	2.7%
850	Pigmentary retinopathy	2.7%
851	Alexia, Pure	2.7%
852	Porokeratosis	2.7%
853	Keratoderma, Palmoplantar	2.7%
854	Cavernous Sinus Thrombosis	2.7%
855	Sagittal Sinus Thrombosis	2.7%
856	Chronic granulomatous disease	2.7%
857	Waterhouse-Friderichsen Syndrome	2.6%
858	Dermatomyositis	2.5%
859	Corneal Scar	2.5%
860	Hoarseness	2.5%
861	Acute Chest Syndrome	2.5%
862	Alkaptonuria	2.5%
863	Glycogen Storage Disease	2.5%
864	Hypophosphatasia	2.5%
865	Propionic acidemia	2.5%
866	Dihydropyrimidine Dehydrogenase Deficiency	2.5%
867	Cystinosis	2.5%
868	Alcohol Withdrawal Delirium	2.5%
869	Ophthalmia Neonatorum	2.5%
870	Retrograde amnesia	2.5%
871	Amnesia, Anterograde	2.5%
872	Carotid Artery Thrombosis	2.5%
873	Denys-Drash Syndrome	2.4%
874	Hydrops Fetalis	2.4%
875	Wernicke Encephalopathy	2.4%
876	AIDS Dementia Complex	2.4%
877	Phantom pain	2.3%
878	Phantom Limb Pain	2.3%
879	Lyme Neuroborreliosis	2.3%
880	Corneal Perforation	2.3%
881	Mucopolysaccharidosis III	2.3%
882	Porphyrias, Hepatic	2.3%
883	Nelson Syndrome	2.2%
884	Peutz-Jeghers Syndrome	2.2%
885	Thrombasthenia	2.2%
886	Antithrombin III Deficiency	2.2%
887	Protein C Deficiency	2.2%
888	Afibrinogenemia	2.2%
889	Factor VII Deficiency	2.2%
890	Factor X Deficiency	2.2%
891	Factor XII Deficiency	2.2%
892	Hemophilia A	2.2%
893	Activated Protein C Resistance	2.2%
894	Factor II deficiency	2.2%
895	Factor VIII Deficiency	2.2%
896	Factor V deficiency	2.2%
897	Factor XI Deficiency	2.2%
898	Hypoprothrombinemias	2.2%
899	Fanconi Anemia	2.2%
900	Nesidioblastosis	2.2%
901	Anemia, Diamond-Blackfan	2.2%
902	Hyperphosphaturia	2.2%
903	Glycogen Storage Disease Type I	2.1%
904	Glycogen Storage Disease Type V	2.1%
905	Hyaline Membrane Disease	2%
906	Prolactinoma	2%
907	Growth Hormone-Secreting Pituitary Adenoma	2%
908	Hypolipoproteinemias	2%
909	Papillon-Lefevre Disease	2%
910	Hyperlipidemia, Familial Combined	2%
911	Multiple Endocrine Neoplasia	2%
912	Hyperlipoproteinemia Type III	2%
913	Congenital Hypothyroidism	1.9%
914	Dermatitis, Atopic	1.9%
915	Behcet Syndrome	1.7%
916	Lactose Intolerance	1.7%
917	Variegate Porphyria	1.7%
918	Acute intermittent porphyria	1.7%
919	Porphyria Cutanea Tarda	1.7%
920	Hyperhomocysteinemia	1.7%
921	Renal Aminoacidurias	1.6%
922	Fanconi Syndrome	1.6%
923	Pseudohypoaldosteronism	1.6%
924	Liddle Syndrome	1.6%
925	Hypoalphalipoproteinemias	1.6%
926	Hyperlipoproteinemia Type IV	1.6%
927	Hyperlipoproteinemia Type V	1.6%
928	Gout	1.4%
929	Multiple Endocrine Neoplasia Type 1	1.4%
930	Pseudohypoparathyroidism	1.4%
931	Renal tubular acidosis	1.4%
932	Cystinuria	1.4%
933	Nephroblastoma	1.3%
934	Adenomatous Polyposis Coli	1.2%
935	Arthritis, Gouty	1.2%
936	Familial Hypophosphatemic Rickets	1.1%
937	Glycosuria, Renal	1.1%

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