MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteopetrosis

(UMLS:C0029454)

Definition:: Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
UMLS ID:: C0029454
MeSH ID:: D010022

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.708.702.678

Synonym(s)

Osteopetrosis

ALBERS-SCHOENBERG DISEASE

Albers Schoenberg disease

Albers-Schoenberg syndrome

Albers-Schonberg disease

Albers-Schonberg syndrome

Albers-Schoonberg syndrome

Albers-Sch枚nberg

Bone thickened

10.

Congenital osteopetrosis

11.

Harder, denser, fracture-prone bones

12.

IVORY BONES

13.

Ivory bones

14.

MARBLE BONES

15.

Marble bone

16.

Marble bone disease

17.

OSTEOSCLEROSIS, GENERALIZED CONGENITAL

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alendronate	FAERS: 8		US FAERS
2	Zoledronic Acid	FAERS: 8		US FAERS
3	Pamidronate	FAERS: 2		US FAERS
4	Deferasirox	FAERS: 1		US FAERS
5	Letrozole	FAERS: 1		US FAERS
6	Medroxyprogesterone Acetate	FAERS: 1		US FAERS
7	Ribavirin	FAERS: 1		US FAERS
8	Teriparatide	FAERS: 1		US FAERS
9	Thyroxine	FAERS: 1		US FAERS
10	Benztropine			OFFSIDES
11	Bromocriptine			OFFSIDES
12	Carboplatin			OFFSIDES
13	Ceftriaxone			OFFSIDES
14	Chlorhexidine			OFFSIDES
15	Dicloxacillin			OFFSIDES
16	Docetaxel			OFFSIDES
17	Fosinopril			OFFSIDES
18	Imatinib Mesylate		21586300	CTD
19	Pamidronate		16227646	CTD OFFSIDES
20	Perphenazine			OFFSIDES
21	Sertraline			OFFSIDES
22	Vinorelbine			OFFSIDES
23	chlorhexidine gluconate			OFFSIDES
24	dolasetron			OFFSIDES
25	gemcitabine			OFFSIDES
26	reviparin			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Melorheostosis	49.2%
2	Chondrodysplasia Punctata	36%
3	Enchondromatosis	36%
4	Kashin-Beck Disease	36%
5	Dysostoses	28.5%
6	Hyperostosis	22.7%
7	Osteitis	22.7%
8	Osteitis Deformans	22.7%
9	Osteochondrosis	22.7%
10	Spinal Diseases	22.7%
11	Gigantism	20.6%
12	Osteoarthropathy, Secondary Hypertrophic	20.6%
13	Osteogenesis Imperfecta	18.7%
14	Pectus excavatum	18.4%
15	Platybasia	18%
16	Bone Diseases, Endocrine	16.2%
17	Bone Diseases, Infectious	15.4%
18	Bone neoplasms	15.4%
19	Osteopenia	15.4%
20	Dwarfism	15.4%
21	Osteochondritis	15.3%
22	Fasciitis	15.3%
23	Foot Deformities	15.3%
24	Arthropathy	15.3%
25	Bone Resorption	15.1%
26	Aseptic Necrosis of Bone	15.1%
27	Pectus carinatum	14.9%
28	Klippel-Feil Syndrome	12.4%
29	Synostosis	12.4%
30	Spinal Neoplasms	12.3%
31	Spondylitis	12.3%
32	Ainhum	12.2%
33	Spinal Stenosis	12.2%
34	Spondylosis	12.2%
35	Intervertebral Disc Degeneration	12.2%
36	Jaw Diseases	10.7%
37	Craniofacial Dysostosis	10.5%
38	Contracture	10.3%
39	Fasciitis, Plantar	10.3%
40	Cartilage Diseases	10.2%
41	Foot Diseases	10.2%
42	Myopathy	10.2%
43	Rheumatism	10.2%
44	Chondromalacia	10.2%
45	Congenital Hypothyroidism	10%
46	Arthrogryposis	9.3%
47	Osteomyelitis	8.2%
48	Osteoporosis	8.2%
49	Periostitis	8.2%
50	Bone Demineralization, Pathologic	8.2%
51	Post-Traumatic Osteoporosis	8.2%
52	Alveolar Bone Loss	8.1%
53	Femur Head Necrosis	8.1%
54	Osteolysis	8.1%
55	Fibromyalgia	7.7%
56	Polymyalgia Rheumatica	7.7%
57	Metatarsalgia	7.6%
58	Arthritis	7.6%
59	Bursitis	7.6%
60	Joint Instability	7.6%
61	Myofascial Pain Syndromes	7.6%
62	Rhabdomyolysis	7.6%
63	Synovitis	7.6%
64	Joint laxity	7.6%
65	Polyarthritis	7.6%
66	Frozen shoulder	7.6%
67	Patellofemoral Pain Syndrome	7.6%
68	Eosinophilic Granuloma	7.4%
69	Marfan Syndrome	7.3%
70	Discitis	7.2%
71	Lordosis	7.2%
72	Spondylolysis	7.2%
73	kyphosis	7.2%
74	Craniosynostosis	6.5%
75	Syndactyly	6.5%
76	Brachycephaly	6.5%
77	Basal Cell Nevus Syndrome	6.2%
78	Acromegaly	6.1%
79	Joint Tuberculosis	6.1%
80	Tuberculosis, Osteoarticular	6.1%
81	Bone Tuberculosis	6.1%
82	Rheumatic Fever	5.8%
83	Tuberculosis, Spinal	5.8%
84	Osteoarthritis, Spine	5.5%
85	Mandibulofacial Dysostosis	5.5%
86	Hip Contracture	5.5%
87	Periarthritis	5.5%
88	Rubinstein-Taybi Syndrome	5.3%
89	Gout	5.2%
90	Compartment syndromes	5.1%
91	Maxillary Diseases	5.1%
92	Tendinitis	5.1%
93	Tendinopathy	5.1%
94	Antley-Bixler Syndrome Phenotype	5.1%
95	Hemarthrosis	5%
96	Myositis	5%
97	Tietze's Syndrome	5%
98	Limb Deformities, Congenital	5%
99	Isaacs syndrome	5%
100	Craniofacial Abnormalities	5%
101	Myotonic Disorders	5%
102	Ischemic contracture	5%
103	Cockayne Syndrome	4.9%
104	Goldenhar Syndrome	4.9%
105	Rickets	4.9%
106	Temporomandibular Joint Disorders	4.8%
107	Osteoporosis, Postmenopausal	4.8%
108	Spondylarthropathies	4.8%
109	Acrocephalosyndactylia	4.8%
110	Spondylolisthesis	4.8%
111	Rheumatoid Arthritis	4.7%
112	Juvenile arthritis	4.7%
113	Ankylosing spondylitis	4.6%
114	Poland Syndrome	4.4%
115	Osteoarthritis, Knee	4.3%
116	Pseudohypoparathyroidism	4.1%
117	Bunion	4.1%
118	Fibrodysplasia Ossificans Progressiva	4.1%
119	Myoglobinuria	4.1%
120	Myositis Ossificans	4.1%
121	Tenosynovitis	4.1%
122	Sacroiliitis	4.1%
123	Talipes	3.9%
124	Medial Tibial Stress Syndrome	3.8%
125	Mitochondrial Myopathies	3.8%
126	Muscle Cramp	3.7%
127	Eosinophilia-Myalgia Syndrome	3.7%
128	Gastroschisis	3.7%
129	Arthritis, Psoriatic	3.7%
130	Muscle Rigidity	3.7%
131	Muscle Spasticity	3.7%
132	Cogwheel Rigidity	3.7%
133	Nuchal Rigidity	3.7%
134	Mastoiditis	3.6%
135	Petrositis	3.6%
136	Temporomandibular Joint Dysfunction Syndrome	3.5%
137	Rheumatoid Nodule	3.2%
138	Chronic Fatigue Syndrome	3.2%
139	Nail-Patella Syndrome	3.1%
140	Arthritis, Reactive	3%
141	Giant Cell Epulis	3%
142	Muscle Weakness	3%
143	Musculoskeletal Pain	3%
144	Familial Periodic Paralysis	3%
145	Arthralgia	3%
146	Polyarthralgia	3%
147	Arthritis, Gouty	2.9%
148	Osteomalacia	2.9%
149	Jaw Abnormalities	2.8%
150	Arthritis, Infectious	2.8%
151	Anterior Compartment Syndrome	2.7%
152	Enthesopathy	2.7%
153	Arthritis, Experimental	2.7%
154	Abdominal Compartment Syndrome	2.7%
155	Amelia	2.7%
156	Arachnodactyly	2.7%
157	Ectromelia	2.7%
158	Hemimelia	2.7%
159	Phocomelia	2.7%
160	Sirenomelia	2.7%
161	Polymyositis	2.7%
162	Polydactyly	2.7%
163	Brachydactyly	2.7%
164	Plagiocephaly	2.7%
165	Lower Extremity Deformities, Congenital	2.7%
166	Upper Extremity Deformities, Congenital	2.7%
167	Felty Syndrome	2.6%
168	Laryngomalacia	2.6%
169	Palatal Neoplasms	2.6%
170	Myalgia	2.5%
171	Congenital clubfoot	2.4%
172	Vertical Talus	2.4%
173	Rheumatoid Vasculitis	2.2%
174	Prognathism	2.2%
175	Hip Dislocation	2.1%
176	Shoulder Dislocation	2.1%
177	Hip Dysplasia	2.1%
178	Muscular Dystrophy	2.1%
179	Orbital Myositis	2.1%
180	Dupuytren Contracture	2.1%
181	Pyomyositis	2%
182	Nose Neoplasms	1.9%
183	Sicca Syndrome	1.9%
184	Sjogren's Syndrome	1.9%
185	Renal Osteodystrophy	1.8%
186	Renal rickets	1.8%
187	Maxillofacial Abnormalities	1.7%
188	Myotonia Congenita	1.6%
189	Myotonic Dystrophy	1.6%
190	Bronchomalacia	1.6%
191	Tracheomalacia	1.6%
192	Microcephaly	1.6%
193	Macrocephaly	1.6%
194	Micrognathism	1.6%
195	Pierre Robin Syndrome	1.6%
196	Hypokalemic periodic paralysis	1.6%
197	Shoulder Pain	1.6%
198	Retrognathia	1.4%
199	Mitochondrial Encephalomyopathies	1.4%
200	Welander Distal Myopathy	1.2%
201	Noonan Syndrome	1.2%
202	Cleft Palate	1.1%
203	Holoprosencephaly	1%
204	Dermatomyositis	1%
205	Muscular Dystrophy, Duchenne	1%
206	Porencephaly	1%
207	Familial Hypophosphatemic Rickets	0.7%
208	Radicular Cyst	0.5%
209	MELAS Syndrome	0.5%
210	Kearns-Sayre syndrome	0.4%

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