MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lipodystrophy

(UMLS:C0023787)

Definition:: A collection of heterogenous conditions resulting from defective LIPID METABOLISM and characterized by ADIPOSE TISSUE atrophy. Often there is redistribution of body fat resulting in peripheral fat wasting and central adiposity. They include generalized, localized, congenital, and acquired lipodystrophy.
UMLS ID:: C0023787
MeSH ID:: D008060

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.849.391

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.625|C18.452.880.391

Synonym(s)

Lipodystrophy

CUTANEOUS LIPODYSTROPHY

Dystrophy of fatty tissue

Dystrophy, fatty tissue

Inability to make and keep healthy fat tissue

LIPODYSTROPHY

Lipodsystrophic Syndromes

Lipodystrophy, NOS

lipoatrophy

10.

lipodystrophy

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Atazanavir Sulfate		SIDER
2	Darunavir		SIDER
3	Didanosine	23782481	CTD
4	Emtricitabine		SIDER
5	Insulin Glargine		SIDER
6	Lamivudine		SIDER
7	Maraviroc		SIDER
8	Nelfinavir		SIDER
9	Nevirapine		SIDER
10	Niacin	12218390	CTD
11	Prednisone	17501951	CTD
12	Rilpivirine		SIDER
13	Ritonavir	16269669	CTD
14	Saquinavir		SIDER
15	Stavudine	17362559 19732926 23782481	CTD SIDER
16	Tenofovir		SIDER
17	Zidovudine	22293411 23782481	CTD
18	abacavir		SIDER
19	amprenavir		SIDER
20	efavirenz		SIDER
21	etravirine		SIDER
22	fosamprenavir		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Necrobiosis Lipoidica Diabeticorum	39.3%
2	Lipomatosis	39.2%
3	Xanthomatosis	33.3%
4	Dyslipidemias	33.3%
5	Xanthoma	33.3%
6	Wasting Syndrome	32.9%
7	Hypercalcemia	32%
8	Hypocalcemia	32%
9	Milk-Alkali Syndrome	32%
10	Acid-Base Imbalance	30.5%
11	Calcium Metabolism Disorders	30.5%
12	Iron Metabolism Disorders	30.5%
13	Phosphorus Metabolism Disorders	30.5%
14	Water-Electrolyte Imbalance	30.5%
15	Mitochondrial Diseases	30.5%
16	Glucose Metabolism Disorders	30.5%
17	Hyperlipoproteinemia Type IV	29.2%
18	Hyperlipoproteinemia Type V	29.2%
19	Adiposis Dolorosa	27.8%
20	Pseudohypoparathyroidism	27.3%
21	Hypolipoproteinemias	26.2%
22	Rickets	24.8%
23	Osteopenia	24.7%
24	Leigh Disease	24.4%
25	Brain Diseases, Metabolic	24.3%
26	Smith-Lemli-Opitz Syndrome	24%
27	Hyperlipidemia, Familial Combined	23.4%
28	Brain Diseases, Metabolic, Inborn	22.7%
29	Carbamoyl-Phosphate Synthase I Deficiency Disease	22.3%
30	Hyperlipoproteinemia Type III	22%
31	Xeroderma Pigmentosum	22%
32	Hyperhomocysteinemia	21.8%
33	Hypoalphalipoproteinemias	21.7%
34	Gaucher Disease	21%
35	Hypercholesterolemia	20.6%
36	Hyperlipoproteinemias	20.6%
37	Hypertriglyceridemia	20.6%
38	Sjogren-Larsson Syndrome	20.4%
39	Familial Hypophosphatemic Rickets	20.1%
40	Acidosis	20%
41	Alkalosis	20%
42	Amyloidosis	20%
43	Calcinosis	20%
44	Hyperglycemia	20%
45	Hyperinsulinism	20%
46	Hyperkalemia	20%
47	Hypernatremia	20%
48	Hypoglycemia	20%
49	Hypokalemia	20%
50	Hyponatremia	20%
51	Pyoderma Gangrenosum	20%
52	Hypophosphatemia	20%
53	Metabolic acidosis	20%
54	Iron Overload	20%
55	Lactose Intolerance	19.7%
56	Galactosemias	19.5%
57	Urea Cycle Disorders, Inborn	19.5%
58	Tyrosinemias	19.5%
59	Tay-Sachs Disease	18.7%
60	Osteomalacia	18.7%
61	Homocystinuria	18.7%
62	Neuronal Ceroid-Lipofuscinoses	18.4%
63	Diabetic Ketoacidosis	18.1%
64	Niemann-Pick Disease, Type C	18%
65	Hyperphosphaturia	17.6%
66	Nutrition Disorders	17.5%
67	Glycogen storage disease type II	17.5%
68	Porphyrias, Hepatic	17.3%
69	Congenital Hyperinsulinism	17.3%
70	Mitochondrial Encephalomyopathies	17.3%
71	Fabry Disease	16.9%
72	Diabetes Mellitus	16.7%
73	Menkes Kinky Hair Syndrome	16.5%
74	Lupus Erythematosus, Cutaneous	16.4%
75	Panniculitis	16.4%
76	Systemic Scleroderma	16.4%
77	Morphea	16.4%
78	Dehydration	16.2%
79	Water Intoxication	16.2%
80	Werner Syndrome	16.2%
81	Achlorhydria	16%
82	Acne Vulgaris	16%
83	Amino Acid Metabolism, Inborn Errors	16%
84	Bloom Syndrome	16%
85	Carbohydrate Metabolism, Inborn Errors	16%
86	Contact Dermatitis	16%
87	Eczema	16%
88	Erythema Multiforme	16%
89	Intertrigo	16%
90	Metal Metabolism, Inborn Errors	16%
91	Neurodermatitis	16%
92	Osteoporosis	16%
93	Progeria	16%
94	Rhinophyma	16%
95	Lysosomal Storage Diseases	16%
96	Bone Demineralization, Pathologic	16%
97	Perioral Dermatitis	16%
98	Cytochrome-c Oxidase Deficiency	16%
99	Peroxisomal Disorders	16%
100	Acne	16%
101	Post-Traumatic Osteoporosis	16%
102	Celiac Disease	15.9%
103	Sprue, Tropical	15.9%
104	Steatorrhea	15.9%
105	Sprue	15.9%
106	Amyloid Neuropathies, Familial	15.7%
107	Breast Diseases	15.3%
108	Dermatitis	15.3%
109	Exanthema	15.3%
110	Facial Dermatoses	15.3%
111	Hair Diseases	15.3%
112	Hand Dermatoses	15.3%
113	keratoacanthoma	15.3%
114	Keratosis	15.3%
115	Nail Diseases	15.3%
116	Photosensitivity Disorders	15.3%
117	Prurigo	15.3%
118	Pyoderma	15.3%
119	Rosacea	15.3%
120	Sebaceous Gland Diseases	15.3%
121	Skin Diseases, Vesiculobullous	15.3%
122	Skin Ulcer	15.3%
123	Sweat Gland Diseases	15.3%
124	Lipid Metabolism Disorders	15.3%
125	Skin Diseases, Papulosquamous	15.3%
126	Skin Diseases, Vascular	15.3%
127	Acneiform Eruptions	15.3%
128	Ocular Rosacea	15.3%
129	Subcorneal pustular dermatosis	15.3%
130	Erythematotelangiectatic Rosacea	15.3%
131	Papulopustular Rosacea	15.3%
132	Chronic Actinic Dermatitis	15.3%
133	Dermatitis, Atopic	15%
134	Epidermolysis Bullosa	15%
135	Acidosis, Lactic	14.9%
136	Calciphylaxis	14.9%
137	Hemosiderosis	14.9%
138	Ketosis	14.9%
139	Ketonuria	14.9%
140	Ketoacidosis	14.9%
141	Ketonemia	14.9%
142	Vascular calcification	14.9%
143	Dermatitis, Phototoxic	14.8%
144	Pityriasis Lichenoides et Varioliformis Acuta	14.8%
145	Pityriasis Lichenoides	14.8%
146	Phototoxicity	14.8%
147	Renal tubular acidosis	14.7%
148	Adrenoleukodystrophy	14.3%
149	Nesidioblastosis	14.1%
150	Foot Ulcer	13.9%
151	MELAS Syndrome	13.7%
152	Zellweger Syndrome	13.7%
153	Dermatitis Herpetiformis	13.5%
154	Mitochondrial Myopathies	13.5%
155	Myelinolysis, Central Pontine	13.4%
156	Mucopolysaccharidosis III	13.4%
157	Acrodermatitis	13.3%
158	Lipodystrophy	13.3%
159	Sebaceous Gland Neoplasms	13.3%
160	Porokeratosis	13.3%
161	Gianotti-Crosti Syndrome	13.3%
162	Keratoderma, Palmoplantar	13.3%
163	Glycosuria	13.3%
164	Reye Syndrome	13.3%
165	Panniculitis, Lupus Erythematosus	13.2%
166	HIV Wasting Syndrome	13.2%
167	Hepatic Encephalopathy	13.2%
168	Ichthyosis, X-Linked	13.2%
169	Renal Osteodystrophy	13.1%
170	Renal rickets	13.1%
171	Albinism	13%
172	Hepatolenticular Degeneration	12.7%
173	Foot Diseases	12.7%
174	Variegate Porphyria	12.7%
175	Acute intermittent porphyria	12.7%
176	Porphyria Cutanea Tarda	12.7%
177	Dermatitis, Photoallergic	12.6%
178	Refsum Disease	12.5%
179	Skin Abnormalities	12.3%
180	Skin Diseases, Infectious	12.3%
181	Skin Neoplasms	12.3%
182	Pigmentation Disorders	12.3%
183	Pruritus	12.2%
184	Erythema	12.2%
185	Necrolytic Migratory Erythema	12.2%
186	Cutaneous Fistula	12.2%
187	Nephrogenic Fibrosing Dermopathy	12.2%
188	Nephrogenic Systemic Fibrosis	12.2%
189	Acidosis, Respiratory	11.9%
190	Alkalosis, Respiratory	11.9%
191	Alkaptonuria	11.8%
192	Glycogen Storage Disease	11.8%
193	Hypophosphatasia	11.8%
194	Insulin Resistance	11.8%
195	Osteoporosis, Postmenopausal	11.8%
196	Dermatitis, Irritant	11.8%
197	Acne Conglobata	11.8%
198	Propionic acidemia	11.8%
199	Dihydropyrimidine Dehydrogenase Deficiency	11.8%
200	Cystinosis	11.8%
201	Glycosuria, Renal	11.7%
202	Wernicke Encephalopathy	11.6%
203	Erythema Induratum	11.6%
204	Xeroderma	11.5%
205	Dermatomyositis	11.5%
206	Urticaria Pigmentosa	11.5%
207	Fanconi Anemia	11.3%
208	CREST Syndrome	10.9%
209	Lupus Erythematosus, Discoid	10.7%
210	Scleroderma, Limited	10.7%
211	Dermatitis, Occupational	10.2%
212	Child Nutrition Disorders	10.2%
213	Hypervitaminosis A	10.2%
214	Infant Nutrition Disorders	10.2%
215	Gestational Diabetes	10.2%
216	Malnutrition	10.2%
217	Latent Autoimmune Diabetes in Adults	10.2%
218	Cutis Laxa	10.1%
219	Diabetes Mellitus, Experimental	10.1%
220	Mastocytosis	10.1%
221	Erythema Infectiosum	10%
222	Pseudoxanthoma Elasticum	10%
223	Anhidrosis	10%
224	Cholesteatoma	10%
225	Pressure Ulcer	10%
226	Ectodermal Dysplasia	10%
227	Exanthema Subitum	10%
228	Folliculitis	10%
229	Foot Dermatoses	10%
230	Gynecomastia	10%
231	Hypertrichosis	10%
232	Hypohidrosis	10%
233	Hypotrichosis	10%
234	Leg Ulcer	10%
235	Miliaria	10%
236	Parakeratosis	10%
237	Parapsoriasis	10%
238	Pityriasis	10%
239	Psoriasis	10%
240	Sweet Syndrome	10%
241	Hidradenitis	10%
242	Onycholysis	10%
243	Miliaria Rubra	10%
244	Hyperpigmentation	10%
245	Lichenoid Eruptions	10%
246	Chloracne	10%
247	Aplasia Cutis Congenita	10%
248	Nephrocalcinosis	9.9%
249	Tetany	9.9%
250	Dermatitis, Allergic Contact	9.9%
251	Erythema Nodosum	9.9%
252	Papillon-Lefevre Disease	9.8%
253	Toxic Epidermal Necrolysis	9.8%
254	Stevens-Johnson Syndrome	9.8%
255	Friedreich Ataxia	9.8%
256	Diaper Rash	9.8%
257	Glycogen Storage Disease Type I	9.8%
258	Glycogen Storage Disease Type V	9.8%
259	Cerebral Amyloid Angiopathy	9.8%
260	Kearns-Sayre syndrome	9.7%
261	Mucopolysaccharidosis II	9.7%
262	Tinea Capitis	9.1%
263	Onychomycosis	9.1%
264	Kernicterus	8.9%
265	Canavan Disease	8.9%
266	Alexander Disease	8.9%
267	Cockayne Syndrome	8.9%
268	Connective Tissue Diseases	8.8%
269	Hyperkeratosis, Epidermolytic	8.6%
270	Ecthyma	8.6%
271	Familial Periodic Paralysis	8.6%
272	Primary amyloidosis	8.5%
273	Renal Aminoacidurias	8.4%
274	Fanconi Syndrome	8.4%
275	Pseudohypoaldosteronism	8.4%
276	Liddle Syndrome	8.4%
277	Granuloma Annulare	8.3%
278	Acantholysis	8.1%
279	Breast Cyst	8.1%
280	Actinic keratosis	8.1%
281	Pemphigoid, Benign Mucous Membrane	8.1%
282	Pemphigus	8.1%
283	Piedra	8.1%
284	Sunburn	8.1%
285	Ataxia Telangiectasia	8.1%
286	Argyria	8%
287	Hirsutism	8%
288	Lactation Disorder	8%
289	Mastitis	8%
290	Urticaria	8%
291	Pruritus Vulvae	7.9%
292	Mastocytoma	7.9%
293	Pruritus Ani	7.9%
294	Optic Atrophy, Hereditary, Leber	7.9%
295	Behcet Syndrome	7.8%
296	Gout	7.5%
297	Amyotrophic Lateral Sclerosis	7.5%
298	Lichen Planus	7.4%
299	Melanosis	7.4%
300	Chloasma	7.4%
301	Pityriasis Rosea	7.4%
302	Pityriasis Rubra Pilaris	7.4%
303	Vitiligo	7.4%
304	Lichen Nitidus	7.4%
305	Hidradenitis Suppurativa	7.4%
306	Antley-Bixler Syndrome Phenotype	7.4%
307	Hypokalemic periodic paralysis	7%
308	Frontotemporal dementia	7%
309	Cystinuria	6.9%
310	Erythema Chronicum Migrans	6.9%
311	Dermatomycoses	6.7%
312	Mucocutaneous Lymph Node Syndrome	6.7%
313	Skin Diseases, Bacterial	6.7%
314	Tinea Pedis	6.7%
315	Deficiency Diseases	6.7%
316	Drug Eruptions	6.7%
317	Starvation	6.7%
318	Livedo Reticularis	6.7%
319	Malignant Atrophic Papulosis	6.7%
320	Refeeding Syndrome	6.7%
321	Polyarteritis Nodosa	6.6%
322	Takayasu Arteritis	6.6%
323	HIV-Associated Lipodystrophy Syndrome	6.5%
324	Acanthosis Nigricans	6.2%
325	Alopecia Areata	6.2%
326	Lentigo	6.2%
327	Arthritis, Gouty	6.1%
328	Alopecia	6%
329	Sweating, Gustatory	6%
330	Androgenetic Alopecia	6%
331	Auriculotemporal Syndrome	6%
332	Lice Infestations	6%
333	Varicose Ulcer	6%
334	Breast Neoplasms, Male	6%
335	Triple Negative Breast Neoplasms	6%
336	Galactorrhea	5.9%
337	Mycetoma	5.9%
338	Nail-Patella Syndrome	5.8%
339	Collagen Diseases	5.1%
340	Mixed Connective Tissue Disease	5.1%
341	Mucinoses	5.1%
342	Larva Migrans	5%
343	Leishmaniasis	5%
344	Molluscum Contagiosum	5%
345	Lichen Planus, Oral	5%
346	Angioedema	5%
347	Onchocerciasis	5%
348	Kwashiorkor	5%
349	Magnesium Deficiency	5%
350	Potassium Deficiency	5%
351	Protein Deficiency	5%
352	Avitaminosis	5%
353	Chromoblastomycosis	4.9%
354	Dermatophytosis	4.9%
355	Sporotrichosis	4.9%
356	Tinea	4.9%
357	Tinea Versicolor	4.9%
358	Trichophytosis	4.9%
359	Hyalohyphomycosis	4.9%
360	Acute Generalized Exanthematous Pustulosis	4.9%
361	Warts	4.3%
362	Candidiasis, Chronic Mucocutaneous	4.2%
363	Cutaneous Candidiasis	4.2%
364	Cartilage Diseases	4.2%
365	Erysipelas	4.2%
366	Rheumatism	4.2%
367	Serum Sickness	4.2%
368	Staphylococcal Skin Infections	4.2%
369	Chondromalacia	4.2%
370	Erythrasma	4.2%
371	Carcinoma, Lobular	4.2%
372	Arthritis, Psoriatic	4.2%
373	Ascorbic Acid Deficiency	4.1%
374	Vitamin A Deficiency	4.1%
375	Vitamin D Deficiency	4.1%
376	Vitamin E Deficiency	4.1%
377	Marasmus	4.1%
378	Leishmaniasis, Cutaneous	4.1%
379	Lupus Erythematosus, Systemic	4.1%
380	Overlap syndrome	4.1%
381	Eczema Herpeticum	4.1%
382	Fusariosis	4.1%
383	Giant Cell Arteritis	3.9%
384	Temporal Arteritis	3.9%
385	Obesity	3.7%
386	Folic Acid Deficiency	3.7%
387	Pellagra	3.7%
388	Thiamine Deficiency	3.7%
389	Vitamin B 12 Deficiency	3.7%
390	Vitamin B 6 Deficiency	3.7%
391	Pyridoxine Deficiency	3.7%
392	Hereditary Angioedema Type III	3.7%
393	Hereditary Angioedema Types I and II	3.7%
394	Angioedemas, Hereditary	3.6%
395	Epidermodysplasia Verruciformis	3.5%
396	Herpes Labialis	3.5%
397	Diabetic Foot	3.5%
398	Beriberi	3.5%
399	Staphylococcal Scalded Skin Syndrome	3.5%
400	Dupuytren Contracture	3.3%
401	Scleromyxedema	3.3%
402	Blastomycosis	3.3%
403	Obesity, Abdominal	3.2%
404	Peutz-Jeghers Syndrome	3.2%
405	carbuncle	3.1%
406	Condylomata Acuminata	3.1%
407	Furunculosis	3.1%
408	furuncle	3.1%
409	Impetigo	3%
410	Rhinoscleroma	3%
411	Cellulitis	2.9%
412	Pediatric Obesity	2.8%
413	Anemia, Pernicious	2.8%
414	Vitamin K Deficiency	2.8%
415	Mesenteric Panniculitis	2.7%
416	Panniculitis, Peritoneal	2.7%
417	Tietze's Syndrome	2.7%
418	Orbital Cellulitis	2.7%
419	Myxoid cyst	2.7%
420	Myxedema	2.7%
421	Prader-Willi Syndrome	2.5%
422	Scurvy	2.5%
423	Osteochondritis	2.3%
424	Polymyalgia Rheumatica	2.3%
425	Osteogenesis Imperfecta	2.2%
426	Noonan Syndrome	2.2%
427	Keloid	2.2%
428	Marfan Syndrome	2%
429	Rheumatoid Arthritis	1.9%
430	Juvenile arthritis	1.9%
431	Lupus Nephritis	1.9%
432	Subacute Combined Degeneration	1.8%
433	Laryngomalacia	1.7%
434	Pectus carinatum	1.7%
435	Rheumatoid Nodule	1.6%
436	Felty Syndrome	1.4%
437	Bronchomalacia	1.4%
438	Tracheomalacia	1.4%
439	Rheumatoid Vasculitis	1.2%
440	Sicca Syndrome	1.1%
441	Sjogren's Syndrome	1.1%
442	Lupus Vasculitis, Central Nervous System	0.9%

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