MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Optic Neuropathy, Ischemic

(UMLS:C0155305)

Definition:: Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)
UMLS ID:: C0155305
MeSH ID:: D018917

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.292.700.600

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.640.643

Classification 3:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.601

Synonym(s)

Optic Neuropathy, Ischemic

AION - Acute ischaemic optic neuropathy

AION - Acute ischemic optic neuropathy

ION - Ischaemic optic neuropathy

ION - Ischemic optic neuropathy

Ischaemic optic neuropathy

Ischemic optic neuropathy

OPTIC NEUROPATHY ISCHEMIC

Optic ischaemic neuropathy

10.

ischaemic optic neuropathy

11.

ischemic neuropathy optic

12.

ischemic optic neuropathy

13.

ischemic; neuropathic, optic nerve

14.

optic nerve ischemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Amiodarone	10070533	CTD
2	Carboplatin	16876514	CTD
3	Dapsone	16215545	CTD
4	Epinephrine	2141858	CTD
5	Ergotamine	9759393	CTD
6	Fosinopril	18769283	CTD
7	Hydralazine	18769283	CTD
8	Nifedipine	18769283	CTD
9	Omeprazole	9224084	CTD
10	Oxymetazoline	9933016	CTD
11	Phentermine	15543177	CTD
12	Ribavirin	View details 15459850 15980766 17589934 19201118	CTD
13	Sildenafil Citrate	View details 11315976 11874765 13129901 15756125 16732206 18347465	CTD
14	Sumatriptan	8014044	CTD
15	Timolol	10511024	CTD
16	candesartan	18769283	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Optic Atrophy	36.1%
2	Optic Neuritis	36.1%
3	Papilledema	36.1%
4	Retinal Vein Occlusion	26.2%
5	Aortic Aneurysm	24.7%
6	Aortitis	24.7%
7	Leriche Syndrome	24.7%
8	Periphlebitis	24.7%
9	Phlebitis	24.7%
10	Thromboangiitis Obliterans	24.7%
11	Thrombophlebitis	24.2%
12	Myocardial Ischemia	22.5%
13	Postphlebitic Syndrome	22.4%
14	Carotid Artery Thrombosis	21.8%
15	Aortic Rupture	21.7%
16	Ocular Motility Disorders	21.7%
17	Cyclophoria	21.7%
18	Coronary Aneurysm	21.3%
19	Moyamoya Disease	21.2%
20	Aneurysm	21.1%
21	Angiomatosis	21.1%
22	Aortic Diseases	21.1%
23	Arterial Occlusive Diseases	21.1%
24	Hyperemia	21.1%
25	Hypotension	21.1%
26	Superior Vena Cava Syndrome	21.1%
27	Telangiectasis	21.1%
28	Vasculitis	21.1%
29	Venous Insufficiency	21.1%
30	Peripheral Vascular Diseases	21.1%
31	Embolism and Thrombosis	21.1%
32	Angiodysplasia	21.1%
33	Capillary Leak Syndrome	21.1%
34	Prehypertension	21.1%
35	Low Tension Glaucoma	20.8%
36	Blue Toe Syndrome	20.8%
37	Malignant Atrophic Papulosis	20.5%
38	Shwartzman Phenomenon	20.3%
39	Aortic Aneurysm, Abdominal	20.3%
40	Aortic Aneurysm, Thoracic	20.3%
41	Myocardial Reperfusion Injury	20.3%
42	Intracranial Embolism and Thrombosis	20.2%
43	Carotid Stenosis	19.9%
44	Intracranial Aneurysm	19.9%
45	Coronary Thrombosis	19.6%
46	Coronary Artery Disease	19.6%
47	Cerebrovascular Disorders	19.4%
48	Cerebrovascular Insufficiency	19.4%
49	Spinal Cord Vascular Diseases	19.4%
50	Vasculitis, Central Nervous System	19.1%
51	Thoracic Outlet Syndrome	18.6%
52	Intracranial Arteriosclerosis	18.1%
53	Cerebral Atherosclerosis	18.1%
54	Cerebral Arteriosclerosis	18.1%
55	Retinal Artery Occlusion	18.1%
56	Retinal Vasculitis	18.1%
57	Hypertensive Retinopathy	18.1%
58	Vascular System Injuries	17.4%
59	Cerebral Thrombosis	17.2%
60	Intracranial Embolism	17.2%
61	Intracranial Thrombosis	17.2%
62	Giant Cell Arteritis	17.1%
63	Temporal Arteritis	17.1%
64	Arteriovenous fistula	17%
65	Compartment syndromes	16.9%
66	Hepatic Veno-Occlusive Disease	16.9%
67	Peliosis Hepatis	16.9%
68	Varicocele	16.9%
69	Polyarteritis Nodosa	16.9%
70	Takayasu Arteritis	16.9%
71	Diabetic Angiopathies	16.7%
72	Reperfusion Injury	16.7%
73	Splenic Infarction	16.7%
74	Vascular Neoplasms	16.7%
75	Hand-Arm Vibration Syndrome	16.7%
76	Vasoplegia	16.7%
77	Brain Infarction	16.6%
78	Hemorrhoids	16.6%
79	Infarction, Middle Cerebral Artery	16.5%
80	Infarction, Anterior Cerebral Artery	16.5%
81	Infarction, Posterior Cerebral Artery	16.5%
82	Coronary heart disease	16.4%
83	Myocardial Infarction	16.4%
84	Acute Coronary Syndrome	16.4%
85	Subarachnoid Hemorrhage, Traumatic	16.2%
86	Carotid Artery, Internal, Dissection	16.2%
87	Neuromyelitis Optica	16%
88	Vagus Nerve Disorder	15.8%
89	Glossopharyngeal Neuralgia	15.8%
90	Abducens Nerve Diseases	15.8%
91	Trochlear Nerve Diseases	15.8%
92	Sinus Thrombosis, Intracranial	15.7%
93	Aneurysm, Dissecting	15.5%
94	Arteriosclerosis	15.5%
95	Arteritis	15.5%
96	Embolism	15.5%
97	Erythromelalgia	15.5%
98	Fibromuscular Dysplasia	15.5%
99	Malignant Hypertension	15.5%
100	Raynaud Disease	15.5%
101	Thromboembolism	15.5%
102	Thrombosis	15.5%
103	Essential Hypertension	15.5%
104	Aneurysm, Ruptured	15.5%
105	Iliac Aneurysm	15.5%
106	Pulmonary artery stenosis	15.5%
107	White Coat Hypertension	15.5%
108	Systemic Vasculitis	15.5%
109	Embolus	15.5%
110	Vertebral Artery Dissection	15.2%
111	Cavernous Sinus Thrombosis	15%
112	Sagittal Sinus Thrombosis	15%
113	Ophthalmoplegic Migraine	14.9%
114	Diabetic Retinopathy	14.9%
115	Cerebral Infarction	14.8%
116	Brain Stem Infarctions	14.8%
117	Lemierre Syndrome	14.8%
118	Carotid Artery Injuries	14.4%
119	Carotid Artery Diseases	14.3%
120	Brain Ischemia	14.3%
121	Hypotension, Orthostatic	14.3%
122	Cerebrovascular accident	14.3%
123	Vasospasm, Intracranial	14.3%
124	Spinal Cord Ischemia	14.3%
125	Intracranial Arterial Diseases	14.3%
126	Post-Exercise Hypotension	14.3%
127	Mesenteric vascular insufficiency	14%
128	Lateral Medullary Syndrome	14%
129	Strabismus	13.9%
130	Tolosa-Hunt Syndrome	13.9%
131	Duane Retraction Syndrome	13.9%
132	Kounis Syndrome	13.8%
133	Optic Atrophy, Hereditary, Leber	13.8%
134	Sturge-Weber Syndrome	13.7%
135	Angioedema	13.6%
136	Colitis, Ischemic	13.6%
137	May-Thurner Syndrome	13.6%
138	Angina Pectoris	13.5%
139	Coronary Occlusion	13.5%
140	Microvascular Angina	13.5%
141	Coronary Stenosis	13.5%
142	ST segment elevation myocardial infarction	13.5%
143	Basal Ganglia Cerebrovascular Disease	13.5%
144	Optic Nerve Glioma	13.4%
145	Vascular Headaches	13.2%
146	Embolism, Amniotic Fluid	13.1%
147	Basal Ganglia Hemorrhage	13%
148	Olfactory Nerve Injuries	13%
149	Arteriosclerosis Obliterans	12.8%
150	Atherosclerosis	12.8%
151	Air Embolism	12.8%
152	Endarteritis	12.8%
153	Venous Thrombosis	12.8%
154	Deep Vein Thrombosis	12.8%
155	Venous Thromboembolism	12.8%
156	Shy-Drager Syndrome	12.7%
157	Facial Nerve Diseases	12.7%
158	Dementia, Vascular	12.6%
159	Vestibulocochlear Nerve Diseases	12.5%
160	Anterior Compartment Syndrome	12.3%
161	Vasculitis, Leukocytoclastic, Cutaneous	12.3%
162	Gastric Antral Vascular Ectasia	12.3%
163	Abdominal Compartment Syndrome	12.3%
164	Varicose Ulcer	12.2%
165	Primary Graft Dysfunction	12.2%
166	CREST Syndrome	12.2%
167	Coronary Restenosis	12.1%
168	Putaminal Hemorrhage	11.9%
169	Cerebral Arterial Diseases	11.8%
170	Vertebrobasilar Insufficiency	11.8%
171	Anterior Spinal Artery Syndrome	11.8%
172	Basilar Artery Stenosis	11.8%
173	Vertebral Artery Stenosis	11.8%
174	Intracranial Hemorrhage, Hypertensive	11.8%
175	Transient Cerebral Ischemia	11.8%
176	Ophthalmoplegia	11.7%
177	External Ophthalmoplegia	11.7%
178	Leukomalacia, Periventricular	11.5%
179	Scimitar Syndrome	11.5%
180	Hypoxia-Ischemia, Brain	11.4%
181	Facial Nerve Injuries	11.3%
182	Retinal Degeneration	11.3%
183	Shock, Cardiogenic	11.2%
184	Lupus Vasculitis, Central Nervous System	11.2%
185	Angina, Unstable	11.1%
186	Asthenopia	10.9%
187	Conjunctival Diseases	10.9%
188	Corneal Diseases	10.9%
189	Eyelid Diseases	10.9%
190	Heart Diseases	10.9%
191	Lacrimal Apparatus Diseases	10.9%
192	Lens Diseases	10.9%
193	Ocular Hypertension	10.9%
194	Ocular Hypotension	10.9%
195	Retinal Diseases	10.9%
196	Scleral Diseases	10.9%
197	Vitreous Detachment	10.9%
198	Posterior Vitreous Detachment	10.9%
199	Pupil Disorders	10.7%
200	Subclavian Steal Syndrome	10.6%
201	Opsoclonus-Myoclonus Syndrome	10.5%
202	Retinal Dysplasia	10.4%
203	Intermittent Claudication	10.3%
204	Mesenteric Vascular Occlusion	10.3%
205	Mucocutaneous Lymph Node Syndrome	10.3%
206	Pulmonary Embolism	10.3%
207	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10.3%
208	Miller Fisher Syndrome	10.3%
209	Livedo Reticularis	10.2%
210	Esotropia	10.2%
211	Exotropia	10.2%
212	No-Reflow Phenomenon	10.2%
213	Renal hypertension	10.2%
214	Renal Artery Obstruction	10.2%
215	Renal Artery Stenosis	10.2%
216	Hemangioma, Cavernous	10.1%
217	Scurvy	10.1%
218	Angina Pectoris, Variant	10%
219	Subarachnoid Hemorrhage	9.7%
220	Cerebral Hemorrhage	9.7%
221	Xerophthalmia	9.7%
222	Iridocorneal endothelial syndrome	9.7%
223	Ataxia Telangiectasia	9.7%
224	Progressive supranuclear palsy	9.7%
225	Pituitary Apoplexy	9.6%
226	Aniridia	9.5%
227	Vision Disorders	9.4%
228	Metamorphopsia	9.4%
229	Visual Impairment	9.4%
230	Blepharophimosis	9.3%
231	Uveal Neoplasms	9.3%
232	Hepatic Vein Thrombosis	9.3%
233	Budd-Chiari Syndrome	9.3%
234	Eyelid Neoplasms	9.2%
235	Retinal Hemorrhage	9.2%
236	Pulmonary Infarction	9.2%
237	Demyelinating Diseases	9.1%
238	Demyelination	9.1%
239	Neuromuscular Diseases	9.1%
240	Chronobiology Disorders	9.1%
241	Corneal Scar	9%
242	Keratoconjunctivitis Sicca	9%
243	Cerebral Amyloid Angiopathy	8.7%
244	Ischemic contracture	8.7%
245	Eye Injuries	8.7%
246	Eye Abnormalities	8.7%
247	Eye Infection	8.7%
248	Eye Manifestations	8.7%
249	Eye Neoplasms	8.7%
250	Angioedemas, Hereditary	8.7%
251	Pregnancy Complications, Cardiovascular	8.7%
252	Tricuspid Atresia	8.7%
253	Cardiovascular Abnormalities	8.7%
254	Arrhythmogenic Right Ventricular Dysplasia	8.7%
255	Cryoglobulinemia	8.7%
256	Diabetic Foot	8.6%
257	Congenital nystagmus	8.6%
258	Chorioretinitis	8.5%
259	Motor Neuron Disease	8.5%
260	Behcet Syndrome	8.4%
261	Hypertension, Renovascular	8.4%
262	Hereditary Angioedema Type III	8.3%
263	Hereditary Angioedema Types I and II	8.3%
264	Multiple System Atrophy	8.3%
265	Color blindness	8.2%
266	Aortic Valve Stenosis	8.2%
267	Cardiomyopathy, Dilated	8.2%
268	Facial Neuralgia	8.2%
269	Keratoconjunctivitis	8.2%
270	Pulmonary Valve Stenosis	8.2%
271	Vestibular Neuronitis	8.2%
272	Brain Hemorrhage, Traumatic	8.1%
273	Corneal Ulcer	8%
274	Choroid Hemorrhage	8%
275	Pars Planitis	7.9%
276	Stiff-Person Syndrome	7.9%
277	Granulomatosis with polyangiitis	7.6%
278	Purpura, Hyperglobulinemic	7.5%
279	Trauma, Nervous System	7.5%
280	Retinitis Pigmentosa	7.4%
281	Pigmentary retinopathy	7.4%
282	Polyradiculoneuropathy	7.4%
283	Polyradiculoneuritis	7.4%
284	Restless Legs Syndrome	7.3%
285	Amblyopia	7.3%
286	Horner Syndrome	7.3%
287	Nervous System Neoplasms	7.2%
288	Neurologic Manifestations	7.2%
289	Neurotoxicity Syndromes	7.2%
290	Hypertrophic Cardiomyopathy	7.1%
291	Choroiditis	7.1%
292	Iridocyclitis	7.1%
293	Iritis	7.1%
294	Hypertrophic obstructive cardiomyopathy	7.1%
295	Eye Hemorrhage	7.1%
296	Kearns-Sayre syndrome	7%
297	Angioid Streaks	7%
298	Anisometropia	7%
299	Aphakia	7%
300	Astigmatism	7%
301	Blepharitis	7%
302	Blepharoptosis	7%
303	Blepharospasm	7%
304	Cardiac Tamponade	7%
305	Choroid Diseases	7%
306	Conjunctivitis	7%
307	Corneal edema	7%
308	Corneal Opacity	7%
309	Dacryocystitis	7%
310	Dry Eye Syndromes	7%
311	Ectropion	7%
312	Endocarditis	7%
313	Enophthalmos	7%
314	Entropion	7%
315	Episcleritis	7%
316	Exophthalmos	7%
317	Glaucoma	7%
318	Cardiac Arrest	7%
319	Heart failure	7%
320	Iris Diseases	7%
321	Keratitis	7%
322	Keratoconus	7%
323	Lacrimal Duct Obstruction	7%
324	Lens dislocation	7%
325	Lens Subluxation	7%
326	Mydriasis	7%
327	Myopia	7%
328	Pericardial effusion	7%
329	Pericarditis	7%
330	Pneumopericardium	7%
331	Presbyopia	7%
332	Pterygium	7%
333	Cor pulmonale	7%
334	Retinal Detachment	7%
335	Retinitis	7%
336	Scleritis	7%
337	Uveitis	7%
338	Ventricular Outflow Obstruction	7%
339	Corneal Neovascularization	7%
340	Orbital Pseudotumor	7%
341	Cataract	7%
342	Pinguecula	7%
343	Trichiasis	7%
344	Ventricular Dysfunction	7%
345	Cardiomyopathies	7%
346	Pleuropericarditis	7%
347	Encephalomyelitis	6.9%
348	Prion Diseases	6.9%
349	Autonomic Dysreflexia	6.9%
350	Complex Regional Pain Syndromes	6.9%
351	Bacterial Endocarditis	6.9%
352	Facial Hemiatrophy	6.9%
353	Melkersson-Rosenthal Syndrome	6.9%
354	Uveomeningoencephalitic Syndrome	6.9%
355	Vocal Cord Paralysis	6.9%
356	Hematoma, Subdural	6.9%
357	Hematoma, Epidural, Cranial	6.9%
358	Anisocoria	6.9%
359	Tonic Pupil	6.9%
360	Subacute Combined Degeneration	6.8%
361	Hordeolum	6.8%
362	Heart Block	6.8%
363	Spinal Muscular Atrophy	6.8%
364	Tachycardia	6.8%
365	Tachyarrhythmia	6.8%
366	Progressive Muscular Atrophy	6.8%
367	Corneal Perforation	6.8%
368	Aortic coarctation	6.8%
369	Cor Triatriatum	6.8%
370	Coronary Vessel Anomalies	6.8%
371	Patent ductus arteriosus	6.8%
372	Ebstein Anomaly	6.8%
373	Heart Septal Defects	6.8%
374	Tetralogy of Fallot	6.8%
375	Transposition of Great Vessels	6.8%
376	Hypoplastic Left Heart Syndrome	6.8%
377	Supravalvular aortic stenosis	6.8%
378	Lown-Ganong-Levine Syndrome	6.8%
379	Amyotrophic Lateral Sclerosis	6.8%
380	Meningoencephalitis	6.7%
381	Waldenstrom Macroglobulinemia	6.7%
382	Multiple Myeloma	6.7%
383	Retinoblastoma	6.7%
384	Trachoma	6.7%
385	Acoustic Neuroma	6.6%
386	Parkinson Disease	6.5%
387	Hematoma, Subdural, Intracranial	6.3%
388	Hematoma, Subdural, Chronic	6.3%
389	Hematoma, Subdural, Acute	6.3%
390	Orbital Myositis	6.3%
391	Rheumatoid Vasculitis	6.3%
392	Diplopia	6.2%
393	Scotoma	6.2%
394	Photophobia	6.2%
395	Amaurosis	6.2%
396	Blindness	6.2%
397	Sick Sinus Syndrome	6.2%
398	Marchiafava-Bignami Disease	6.2%
399	MELAS Syndrome	6.1%
400	Lewy Body Disease	6.1%
401	Pseudoxanthoma Elasticum	6.1%
402	Sleep Wake Disorders	6.1%
403	Trigeminal Nerve Disorder	6.1%
404	Guillain-Barre Syndrome	6.1%
405	Striatonigral Degeneration	6%
406	Spinal Cord Injuries	6%
407	Acanthamoeba Keratitis	5.9%
408	Mobius Syndrome	5.9%
409	Bell Palsy	5.9%
410	Keratitis, Herpetic	5.9%
411	Cytomegalovirus Retinitis	5.9%
412	Dural Arteriovenous Fistula	5.9%
413	Herpes Zoster Oticus	5.8%
414	Dandy-Walker Syndrome	5.8%
415	Peripheral Nerve Injuries	5.8%
416	Bacterial conjunctivitis	5.8%
417	Dextrocardia	5.8%
418	Long QT Syndrome	5.8%
419	Pneumocephalus	5.8%
420	Poliomyelitis	5.8%
421	Myasthenia Gravis	5.7%
422	Asterixis	5.7%
423	Ballismus	5.7%
424	Cardiac Output, High	5.6%
425	Myocardial Stunning	5.6%
426	Low Cardiac Output Syndrome	5.6%
427	Causalgia	5.6%
428	Leukoencephalitis, Acute Hemorrhagic	5.6%
429	Adams-Stokes Syndrome	5.6%
430	Atrioventricular Block	5.6%
431	Bundle-Branch Block	5.6%
432	Atrial Premature Complexes	5.6%
433	Sinoatrial Block	5.6%
434	Tachycardia, Paroxysmal	5.6%
435	Supraventricular tachycardia	5.6%
436	Tachycardia, Ventricular	5.6%
437	Wolff-Parkinson-White Syndrome	5.6%
438	Tachycardia, Reciprocating	5.6%
439	Aortopulmonary Septal Defect	5.6%
440	Double Outlet Right Ventricle	5.6%
441	Endocardial Cushion Defects	5.6%
442	Myocardial bridging	5.6%
443	Aorticopulmonary Septal Defect	5.6%
444	Anophthalmos	5.6%
445	Endophthalmitis	5.6%
446	Cardiomegaly	5.6%
447	Microphthalmos	5.6%
448	Pemphigoid, Benign Mucous Membrane	5.6%
449	Postpericardiotomy Syndrome	5.6%
450	Retinopathy of Prematurity	5.6%
451	Orbital Cellulitis	5.6%
452	Retrobulbar Hemorrhage	5.6%
453	Cardiac Hypertrophy	5.6%
454	Corneal Endothelial Cell Loss	5.6%
455	Hyphema	5.5%
456	Retinal Neovascularization	5.5%
457	Vitreous Hemorrhage	5.5%
458	Rheumatic Heart Disease	5.5%
459	Myelitis	5.5%
460	Progressive bulbar palsy	5.5%
461	Bulbar palsy	5.5%
462	Myelitis, Transverse	5.5%
463	Epidural Abscess	5.3%
464	Lambert-Eaton Myasthenic Syndrome	5.3%
465	Brain Diseases	5.3%
466	Dysautonomia	5.3%
467	Meningitis	5.3%
468	Movement Disorders	5.3%
469	Pachymeningitis	5.3%
470	Spinal Cord Diseases	5.3%
471	Heavy Metal Poisoning, Nervous System	5.3%
472	Neuromuscular Junction Diseases	5.3%
473	Tauopathies	5.3%
474	Peripheral Nervous System Diseases	5.3%
475	MPTP Poisoning	5.2%
476	Aortic Valve Insufficiency	5.2%
477	Restrictive cardiomyopathy	5.2%
478	Endocardial Fibroelastosis	5.2%
479	Angle Closure Glaucoma	5.2%
480	Glaucoma, Open-Angle	5.2%
481	Heart Rupture, Post-Infarction	5.2%
482	Macular degeneration	5.2%
483	Mitral Valve Insufficiency	5.2%
484	Mitral Valve Stenosis	5.2%
485	Myocarditis	5.2%
486	Panuveitis	5.2%
487	Pericarditis, Constrictive	5.2%
488	Pulmonary Valve Insufficiency	5.2%
489	Retinal Drusen	5.2%
490	Retinal Necrosis Syndrome, Acute	5.2%
491	Tricuspid Valve Insufficiency	5.2%
492	Tricuspid Valve Stenosis	5.2%
493	Retinoschisis	5.2%
494	Exfoliation Syndrome	5.2%
495	Ventricular Dysfunction, Left	5.2%
496	Right Ventricular Dysfunction	5.2%
497	Endomyocardial Fibrosis	5.2%
498	Carditis	5.2%
499	Heart Failure, Systolic	5.2%
500	Heart Failure, Diastolic	5.2%
501	Neuroleptic Malignant Syndrome	5.1%
502	Myelinolysis, Central Pontine	5.1%
503	Chronic Fatigue Syndrome	5.1%
504	Sleep Disorders, Circadian Rhythm	5.1%
505	Hemianopsia	5%
506	Encephalomyelitis, Acute Disseminated	5%
507	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5%
508	Trigeminal Neuralgia	5%
509	Tachycardia, Atrioventricular Nodal Reentry	5%
510	Tachycardia, Ectopic Atrial	5%
511	Tachycardia, Ectopic Junctional	5%
512	Sinus Tachycardia	5%
513	Torsades de Pointes	5%
514	Accelerated Idioventricular Rhythm	5%
515	Truncus Arteriosus, Persistent	5%
516	Panophthalmitis	4.9%
517	Dyskinesia, Drug-Induced	4.9%
518	Botulism	4.9%
519	Central Nervous System Cysts	4.9%
520	Dystonia Musculorum Deformans	4.8%
521	Reflex Sympathetic Dystrophy	4.8%
522	Subdural Effusion	4.8%
523	Parkinsonian Disorders	4.8%
524	Nocturnal Myoclonus Syndrome	4.8%
525	Romano-Ward Syndrome	4.8%
526	Amaurosis Fugax	4.7%
527	Blindness, Cortical	4.7%
528	Subacute Bacterial Endocarditis	4.6%
529	Eye pain	4.6%
530	Leukoencephalopathy, Progressive Multifocal	4.6%
531	Aicardi's syndrome	4.6%
532	Brain Injuries	4.5%
533	Brain Neoplasms	4.5%
534	Multiple Sclerosis	4.5%
535	Spinal Cord Neoplasms	4.5%
536	Noonan Syndrome	4.5%
537	Central Nervous System Infection	4.3%
538	Myopathy	4.3%
539	Epilepsy, Post-Traumatic	4.3%
540	Akathisia, Drug-Induced	4.3%
541	Alstrom Syndrome	4.3%
542	Aortic Valve Prolapse	4.3%
543	Tricuspid Valve Prolapse	4.3%
544	Anterior uveitis	4.3%
545	Uveitis, Posterior	4.3%
546	Takotsubo Cardiomyopathy	4.3%
547	Fabry Disease	4.2%
548	Craniocerebral Trauma	4.2%
549	Parasomnia	4.2%
550	Dyssomnias	4.2%
551	Limbic Encephalitis	4.2%
552	Huntington Disease	4.2%
553	Decerebrate State	4.2%
554	Hemiparesis	4.2%
555	Hydranencephaly	4.2%
556	Meningism	4.2%
557	Neural Tube Defects	4.2%
558	Paresis	4.2%
559	Seizures	4.2%
560	Sensation Disorders	4.2%
561	Tethered Cord Syndrome	4.2%
562	Central Nervous System Neoplasms	4.2%
563	Complex partial seizures	4.2%
564	Iniencephaly	4.2%
565	Craniorachischisis	4.2%
566	Exencephaly	4.2%
567	Monoparesis	4.2%
568	Septo-Optic Dysplasia	4.2%
569	Cortical Dysplasia	4.2%
570	Neurogenic Inflammation	4.2%
571	Gait Disorders, Neurologic	4.2%
572	Neuromuscular Manifestations	4.2%
573	Malformations of Cortical Development	4.2%
574	Sweating, Gustatory	4.1%
575	Auriculotemporal Syndrome	4.1%
576	Sinus Arrhythmia	4.1%
577	Atrial Fibrillation	4.1%
578	Atrial Flutter	4.1%
579	Edema, Cardiac	4.1%
580	Ventricular Fibrillation	4.1%
581	Ventricular Flutter	4.1%
582	Parasystole	4.1%
583	Paroxysmal atrial fibrillation	4.1%
584	Bradycardia	4.1%
585	Diabetic Cardiomyopathies	4.1%
586	Marfan Syndrome	4.1%
587	Cardiomyopathy, Alcoholic	4.1%
588	Ectopia Cordis	4.1%
589	Sudden Cardiac Death	4.1%
590	Left Ventricular Hypertrophy	4.1%
591	Right Ventricular Hypertrophy	4.1%
592	Choroidal Neovascularization	4.1%
593	Single umbilical artery	4.1%
594	Myasthenia Gravis, Autoimmune, Experimental	4.1%
595	Chagas Cardiomyopathy	4.1%
596	Meige Syndrome	4.1%
597	Brachial Plexus Neuritis	4.1%
598	Neuralgic Amyotrophy	4.1%
599	Cerebral Ventriculitis	4.1%
600	Scrapie	4%
601	Central Cord Syndrome	4%
602	Presenile dementia	4%
603	Senile dementia	4%
604	Meningitis, Bacterial	4%
605	Meningitis, Fungal	4%
606	Charcot-Marie-Tooth Disease	4%
607	Lafora Disease	3.9%
608	Unverricht-Lundborg Syndrome	3.9%
609	Chorea	3.9%
610	Acrodynia	3.9%
611	Brain Abscess	3.9%
612	Canavan Disease	3.8%
613	Alexander Disease	3.8%
614	Carcinoid Heart Disease	3.8%
615	Jet Lag Syndrome	3.8%
616	Cerebellar Neoplasms	3.8%
617	Tuberous Sclerosis	3.7%
618	Ophthalmia Neonatorum	3.7%
619	Tarsal Tunnel Syndrome	3.7%
620	Cauda Equina Syndrome	3.7%
621	Posterior Leukoencephalopathy Syndrome	3.7%
622	Posterior reversible encephalopathy syndrome	3.7%
623	Williams Syndrome	3.6%
624	Neurobehavioral Manifestations	3.6%
625	Friedreich Ataxia	3.5%
626	Brain Death	3.5%
627	Coma, Post-Head Injury	3.5%
628	Paraneoplastic Encephalomyelitis	3.5%
629	Akinetic Mutism	3.4%
630	Anoxic Encephalopathy	3.4%
631	Arachnoiditis	3.4%
632	Basal Ganglia Diseases	3.4%
633	Brain Damage, Chronic	3.4%
634	Cerebellar Diseases	3.4%
635	Encephalitis	3.4%
636	Encephalomalacia	3.4%
637	Epilepsy	3.4%
638	Hydrocephalus	3.4%
639	Congenital Hydrocephalus	3.4%
640	Hypothalamic Diseases	3.4%
641	Aseptic Meningitis	3.4%
642	Neuritis	3.4%
643	Polyneuritis	3.4%
644	Radiculitis	3.4%
645	Syringomyelia	3.4%
646	Thalamic Diseases	3.4%
647	Intracranial Hypertension	3.4%
648	Polyneuropathy	3.4%
649	Mononeuritis	3.4%
650	Aura	3.4%
651	CHARGE Syndrome	3.4%
652	Leukoencephalopathy	3.4%
653	Essential Tremor	3.4%
654	Neuroaxonal Dystrophies	3.4%
655	Familial Tremor	3.4%
656	Headache Disorders	3.4%
657	Mononeuropathies	3.4%
658	Intracranial Hypotension	3.4%
659	Brachial Plexus Neuropathies	3.4%
660	Radiculopathy	3.4%
661	Mononeuropathy Multiplex	3.4%
662	Nerve Root Compression	3.4%
663	Brain Edema	3.4%
664	Brain Hypoxia	3.4%
665	Aqueductal Stenosis	3.4%
666	Pneumorrhachis	3.4%
667	Writer's Cramp	3.4%
668	Vertigo	3.4%
669	Alcohol-Induced Disorders, Nervous System	3.4%
670	Herpes Zoster Ophthalmicus	3.4%
671	Dyspnea, Paroxysmal	3.4%
672	Myotonia Congenita	3.4%
673	Sinus Arrest, Cardiac	3.4%
674	Creutzfeldt-Jakob disease	3.4%
675	Paraneoplastic Cerebellar Degeneration	3.4%
676	Myoclonic Epilepsy	3.4%
677	Epilepsy, Temporal Lobe	3.4%
678	Epilepsy, Rolandic	3.4%
679	Benign Rolandic Epilepsy	3.4%
680	Brain Injuries, Diffuse	3.4%
681	Traumatic Brain Injury	3.4%
682	Cerebrospinal Fluid Otorrhea	3.3%
683	Cerebrospinal Fluid Rhinorrhea	3.3%
684	Neuritis, Autoimmune, Experimental	3.3%
685	Cerebellar Ataxia	3.3%
686	Supratentorial Neoplasms	3.3%
687	Torticollis	3.3%
688	Multiple Sclerosis, Chronic Progressive	3.3%
689	Multiple Sclerosis, Relapsing-Remitting	3.3%
690	Gait Ataxia	3.3%
691	Tuberculosis, Meningeal	3.3%
692	Hepatolenticular Degeneration	3.2%
693	Myotonic Dystrophy	3.2%
694	Carpal Tunnel Syndrome	3.1%
695	neurofibroma	3.1%
696	Sciatica	3.1%
697	Tardive Dyskinesia	3.1%
698	Persistent Vegetative State	3.1%
699	Alice in Wonderland Syndrome	3%
700	Juvenile Myoclonic Epilepsy	3%
701	Myoclonic Epilepsies, Progressive	3%
702	Voice Disorders	3%
703	Voice Disturbance	3%
704	Alcohol Withdrawal Seizures	3%
705	Graves Disease	2.9%
706	Smith-Magenis syndrome	2.9%
707	Brain Concussion	2.9%
708	Akathisia	2.9%
709	Restlessness	2.9%
710	Psychomotor Agitation	2.9%
711	Pituitary Adenoma	2.9%
712	Pituitary Neoplasms	2.9%
713	Mandibulofacial Dysostosis	2.9%
714	Toxoplasmosis, Cerebral	2.8%
715	Refsum Disease	2.8%
716	Brain Diseases, Metabolic	2.8%
717	Myositis	2.8%
718	Cubital Tunnel Syndrome	2.8%
719	Isaacs syndrome	2.8%
720	Arsenic Poisoning	2.8%
721	Dementia	2.8%
722	Myotonic Disorders	2.8%
723	Central Nervous System Fungal Infections	2.8%
724	Conus Medullaris Syndrome	2.8%
725	Myasthenic Syndromes, Congenital	2.8%
726	Diffuse Axonal Injury	2.8%
727	Brain Stem Neoplasms	2.8%
728	Diabetic Neuropathies	2.7%
729	Facial Injuries	2.7%
730	Diabetic Amyotrophy	2.7%
731	Diabetic Autonomic Neuropathy	2.7%
732	Sleep Talking	2.7%
733	Manganese Poisoning	2.7%
734	Sleep Disorders, Intrinsic	2.7%
735	Orthostatic intolerance	2.7%
736	Anosmia	2.7%
737	Ataxia	2.7%
738	Athetosis	2.7%
739	Catalepsy	2.7%
740	Dystonia	2.7%
741	Hemiplegia	2.7%
742	Locked-In Syndrome	2.7%
743	Meningeal Neoplasms	2.7%
744	Meningomyelocele	2.7%
745	Muscle Hypertonia	2.7%
746	Muscle hypotonia	2.7%
747	Myoclonus	2.7%
748	Myotonia	2.7%
749	Neuralgia	2.7%
750	Paraplegia	2.7%
751	Pseudobulbar Palsy	2.7%
752	Quadriplegia	2.7%
753	Spasm	2.7%
754	Spastic Paraplegia	2.7%
755	Status Epilepticus	2.7%
756	Taste Disorders	2.7%
757	Tremor	2.7%
758	Spina Bifida	2.7%
759	Monoplegia	2.7%
760	Hypokinesia	2.7%
761	Paraparesis	2.7%
762	Bradykinesia	2.7%
763	Waxy flexibility	2.7%
764	Action Tremor	2.7%
765	Resting Tremor	2.7%
766	Dysosmia	2.7%
767	Quadriparesis	2.7%
768	Mercury Poisoning, Nervous System	2.7%
769	Olfaction Disorders	2.7%
770	Myokymia	2.7%
771	Lead Poisoning, Nervous System	2.7%
772	Somatosensory Disorders	2.7%
773	Neuropathic pain	2.7%
774	Hyperkinesia	2.7%
775	Intention tremor	2.7%
776	Amnesia, Transient Global	2.7%
777	Gait Apraxia	2.7%
778	Albinism	2.7%
779	Meningitis, Cryptococcal	2.6%
780	Meningitis, Listeria	2.6%
781	Meningitis, Haemophilus	2.6%
782	Meningitis, Pneumococcal	2.6%
783	Frontotemporal dementia	2.6%
784	Cerebral Palsy	2.6%
785	Epilepsies, Partial	2.6%
786	Epilepsy, Generalized	2.6%
787	Pseudotumor Cerebri	2.6%
788	Sciatic Neuropathy	2.6%
789	Hypertensive Encephalopathy	2.6%
790	Ulnar Neuropathies	2.6%
791	Lesion of Sciatic Nerve	2.6%
792	Simple Partial Seizures	2.6%
793	Epilepsy, Reflex	2.6%
794	Ulnar Neuritis	2.6%
795	Radial nerve compression	2.6%
796	Radial Tunnel Syndrome	2.6%
797	Peroneal Neuropathies	2.6%
798	Radial Neuropathy	2.6%
799	Median Neuropathy	2.6%
800	Sciatic Nerve Palsy	2.6%
801	Femoral Neuropathy	2.6%
802	Tibial Neuropathy	2.6%
803	Ulnar Nerve Palsy	2.6%
804	Postural Orthostatic Tachycardia Syndrome	2.6%
805	Radial nerve palsy	2.6%
806	Headache Disorders, Primary	2.6%
807	Headache Disorders, Secondary	2.6%
808	Medication overuse headache	2.6%
809	Reflex, Abnormal	2.5%
810	Hyporeflexia	2.5%
811	Hyperreflexia	2.5%
812	Mitochondrial Encephalomyopathies	2.5%
813	Choroid Plexus Papilloma	2.5%
814	Turner Syndrome	2.4%
815	Subacute Sclerosing Panencephalitis	2.4%
816	Brain Contusion	2.4%
817	Adrenoleukodystrophy	2.4%
818	Fibromyalgia	2.3%
819	Central Nervous System Bacterial Infections	2.3%
820	Medial Tibial Stress Syndrome	2.3%
821	Amyloid Neuropathies, Familial	2.3%
822	Mitochondrial Myopathies	2.3%
823	Confusion	2.3%
824	Facial paralysis	2.3%
825	Lethargy	2.3%
826	Memory Disorders	2.3%
827	Muscle Cramp	2.3%
828	Perceptual Disorders	2.3%
829	Psychomotor Disorders	2.3%
830	Eosinophilia-Myalgia Syndrome	2.3%
831	Anhedonia	2.3%
832	Disorientation	2.3%
833	Facial Paresis	2.3%
834	Memory Loss	2.3%
835	Hemisensory Neglect	2.3%
836	Dysacusis	2.3%
837	Sleep Bruxism	2.3%
838	Classical Lissencephalies and Subcortical Band Heterotopias	2.3%
839	Anencephaly	2.3%
840	Meningocele	2.3%
841	Muscular Atrophy	2.3%
842	Respiratory Paralysis	2.3%
843	Encephalocele	2.3%
844	Kartagener Syndrome	2.2%
845	Tetany	2.2%
846	Sicca Syndrome	2.2%
847	Sjogren's Syndrome	2.2%
848	Auditory Perceptual Disorders	2.2%
849	Pituitary Diseases	2.1%
850	Polyradiculopathy	2.1%
851	Post-Traumatic Headache	2.1%
852	Tension Headache	2.1%
853	Epilepsy, Complex Partial	2.1%
854	Migraine Disorders	2.1%
855	Abdominal Migraine	2.1%
856	Status Migrainosus	2.1%
857	Cervicogenic Headache	2.1%
858	Alexia	2.1%
859	Dyslexia	2.1%
860	Sleep Apnea Syndromes	2%
861	Polymyositis	2%
862	Kluver-Bucy Syndrome	2%
863	Disorders of Excessive Somnolence	2%
864	Sleep Initiation and Maintenance Disorders	2%
865	Night Terrors	2%
866	Somnambulism	2%
867	Transient Insomnia	2%
868	Sleep Paralysis	2%
869	Chronic Insomnia	2%
870	REM Sleep Behavior Disorder	2%
871	Hypersomnia	2%
872	Dermal Sinus	2%
873	Dysgeusia	2%
874	Formication	2%
875	Hyperalgesia	2%
876	Hyperesthesia	2%
877	Hypesthesia	2%
878	Language Disorders	2%
879	Numbness	2%
880	Paresthesia	2%
881	Paraparesis, Spastic	2%
882	Spina Bifida Cystica	2%
883	Trismus	2%
884	Spina Bifida Occulta	2%
885	Epilepsia Partialis Continua	2%
886	Hypogeusia	2%
887	Meningeal Carcinomatosis	2%
888	Brown-Sequard Syndrome	2%
889	Lissencephaly	2%
890	Polymicrogyria	2%
891	Pachygyria	2%
892	Schizencephaly	2%
893	Lockjaw	2%
894	Allodynia	2%
895	Lead Poisoning, Nervous System, Childhood	2%
896	Lead Poisoning, Nervous System, Adult	2%
897	Periventricular Nodular Heterotopia	2%
898	Ageusia	2%
899	Tuberculosis, Central Nervous System	2%
900	West Nile Fever	2%
901	Consciousness Disorders	2%
902	Mental Retardation	2%
903	Muscle Weakness	2%
904	Depressed Level of Consciousness	2%
905	Mental deficiency	2%
906	Intellectual Disability	2%
907	Catatonia	2%
908	Neurofibrosarcoma	1.9%
909	Familial Periodic Paralysis	1.9%
910	Aphonia	1.9%
911	Sleep Deprivation	1.9%
912	Dysphonia	1.9%
913	Cluster Headache	1.9%
914	Migraine with Aura	1.9%
915	Familial Hemiplegic Migraine	1.9%
916	Chronic Paroxysmal Hemicrania	1.9%
917	SUNCT Syndrome	1.9%
918	Paroxysmal Hemicrania	1.9%
919	Empty Sella Syndrome	1.7%
920	Hyperpituitarism	1.7%
921	Hypopituitarism	1.7%
922	Hypophysitis	1.7%
923	Muscular Dystrophy	1.7%
924	Muscle Rigidity	1.7%
925	Muscle Spasticity	1.7%
926	Cogwheel Rigidity	1.7%
927	Hemifacial Spasm	1.7%
928	Nuchal Rigidity	1.7%
929	Reye Syndrome	1.7%
930	Neuroaspergillosis	1.7%
931	Pyomyositis	1.7%
932	Hepatic Encephalopathy	1.7%
933	Myalgia	1.7%
934	Sleep Apnea, Obstructive	1.7%
935	Sleep Apnea, Central	1.7%
936	Agnosia	1.7%
937	Apraxias	1.7%
938	Hallucinations	1.7%
939	Hyperacusis	1.7%
940	Tinnitus	1.7%
941	Visual Agnosia	1.7%
942	Anosognosia	1.7%
943	Wernicke-Korsakoff Syndrome	1.7%
944	Phonophobia	1.7%
945	Hearing Loss	1.7%
946	Narcolepsy	1.7%
947	Kleine-Levin Syndrome	1.7%
948	Agraphia	1.7%
949	Anomia	1.7%
950	Cluttering	1.7%
951	Language Development Disorders	1.7%
952	Speech Disorders	1.7%
953	Syncope	1.7%
954	Stupor	1.7%
955	Dysgraphia	1.7%
956	Presyncope	1.7%
957	Dyslalia	1.7%
958	Sarcopenia	1.7%
959	Neuronal Ceroid-Lipofuscinoses	1.7%
960	Hyperprolactinemia	1.5%
961	Hoarseness	1.5%
962	Pseudorabies	1.5%
963	Pick Disease of the Brain	1.5%
964	Cataplexy	1.5%
965	Aphasia	1.5%
966	Articulation Disorders	1.5%
967	Echolalia	1.5%
968	Stuttering	1.5%
969	Dysphasia	1.5%
970	Cockayne Syndrome	1.5%
971	Alcohol Withdrawal Delirium	1.5%
972	Amnesia	1.5%
973	Delirium	1.5%
974	Dissociative Amnesia	1.5%
975	Global Amnesia	1.5%
976	Cri-du-Chat Syndrome	1.4%
977	Down Syndrome	1.4%
978	Brain Diseases, Metabolic, Inborn	1.4%
979	Trisomy 21	1.4%
980	POEMS Syndrome	1.4%
981	Meningioma	1.4%
982	Microcephaly	1.4%
983	Macrocephaly	1.4%
984	Neurosyphilis	1.4%
985	Hypokalemic periodic paralysis	1.4%
986	Porencephaly	1.4%
987	Dysarthria	1.4%
988	Toxoplasmosis, Congenital	1.4%
989	Eye Burns	1.4%
990	Malaria, Cerebral	1.4%
991	Welander Distal Myopathy	1.4%
992	Neurocysticercosis	1.4%
993	Dyscalculia	1.4%
994	Rett Syndrome	1.4%
995	Deafness	1.4%
996	Hearing Loss, Sudden	1.4%
997	Gerstmann Syndrome	1.4%
998	Hearing Loss, Bilateral	1.4%
999	Hearing Loss, High-Frequency	1.4%
1000	Hearing Loss, Mixed Conductive-Sensorineural	1.4%
1001	Prosopagnosia	1.4%
1002	Apraxia, Ideomotor	1.4%
1003	Charles Bonnet Syndrome	1.4%
1004	Hearing Loss, Unilateral	1.4%
1005	Complete Hearing Loss	1.4%
1006	Alien Hand Syndrome	1.4%
1007	Deaf Mutism	1.4%
1008	Holoprosencephaly	1.3%
1009	Waterhouse-Friderichsen Syndrome	1.3%
1010	Mutism	1.3%
1011	Selective Mutism	1.3%
1012	Acromegaly	1.3%
1013	Menkes Kinky Hair Syndrome	1.3%
1014	Prader-Willi Syndrome	1.3%
1015	Wernicke Encephalopathy	1.3%
1016	AIDS Dementia Complex	1.3%
1017	Phantom pain	1.2%
1018	Phantom Limb Pain	1.2%
1019	Lyme Neuroborreliosis	1.2%
1020	Dermatomyositis	1.2%
1021	Muscular Dystrophy, Duchenne	1.2%
1022	Retrograde amnesia	1.2%
1023	Amnesia, Anterograde	1.2%
1024	Alexia, Pure	1.2%
1025	Kernicterus	1.1%
1026	Fragile X Syndrome	1%
1027	Nelson Syndrome	1%
1028	Rubinstein-Taybi Syndrome	1%
1029	Prolactinoma	0.9%
1030	Growth Hormone-Secreting Pituitary Adenoma	0.9%
1031	Galactosemias	0.9%
1032	Urea Cycle Disorders, Inborn	0.9%
1033	Tyrosinemias	0.9%
1034	Homocystinuria	0.8%
1035	Leigh Disease	0.8%
1036	Mucopolysaccharidosis II	0.7%
1037	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.7%
1038	Glycogen storage disease type II	0.7%
1039	Zellweger Syndrome	0.6%
1040	Gaucher Disease	0.6%
1041	Tay-Sachs Disease	0.5%
1042	Niemann-Pick Disease, Type C	0.5%

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