MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperesthesia

(UMLS:C0020453)

Definition:: Increased sensitivity to cutaneous stimulation due to a diminished threshold or an increased response to stimuli.
UMLS ID:: C0020453
MeSH ID:: D006941

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.597.751.791.450

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.888.592.763.770.450

Synonym(s)

Hyperesthesia

Cutaneous hyperesthesia

HYPERAESTHESIA

HYPERESTHESIA

Heightened sensation

Heightened sensation of skin

Hyperaesthesia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetaminophen	11004036	CTD
2	Caffeine	18162812	CTD
3	Dichlorvos	12563396	CTD
4	Diethylstilbestrol	5658423	CTD
5	Dinoprostone	8190269	CTD
6	Indomethacin	8190269	CTD
7	Morphine	8190269 8278214	CTD
8	Tegafur	15206584	CTD
9	cyhalothrin	19748519	CTD
10	cypermethrin	19748519	CTD
11	decamethrin	19748519	CTD
12	fenvalerate	19748519	CTD
13	fluoroacetic acid	15206584	CTD
14	icatibant	8190269	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Formication	48.8%
2	Hyperalgesia	48.8%
3	Hypesthesia	48.8%
4	Numbness	48.8%
5	Paresthesia	48.8%
6	Allodynia	48.8%
7	Anosmia	35.2%
8	Taste Disorders	35.2%
9	Dysosmia	35.2%
10	Olfaction Disorders	35.2%
11	Vision Disorders	29.5%
12	Metamorphopsia	29.5%
13	Visual Impairment	29.5%
14	Dysacusis	28.7%
15	Decerebrate State	27%
16	Hemiparesis	27%
17	Meningism	27%
18	Paresis	27%
19	Seizures	27%
20	Complex partial seizures	27%
21	Monoparesis	27%
22	Gait Disorders, Neurologic	27%
23	Neuromuscular Manifestations	27%
24	Dizziness	24.1%
25	Lightheadedness	24.1%
26	Asterixis	23.6%
27	Ballismus	23.6%
28	Dysgeusia	23.2%
29	Hypogeusia	23.2%
30	Ageusia	23.2%
31	Pupil Disorders	22.5%
32	Neurobehavioral Manifestations	22.5%
33	Vertigo	21.5%
34	Diplopia	19%
35	Scotoma	19%
36	Photophobia	19%
37	Amaurosis	19%
38	Blindness	19%
39	Psychophysiologic Disorders	18.9%
40	Sleep Wake Disorders	18.9%
41	Hemianopsia	18.7%
42	Hyperacusis	18.7%
43	Tinnitus	18.7%
44	Phonophobia	18.7%
45	Hearing Loss	18.7%
46	Voice Disorders	18.4%
47	Voice Disturbance	18.4%
48	Amblyopia	17.5%
49	Gait Ataxia	17.5%
50	Alice in Wonderland Syndrome	17.4%
51	Orthostatic intolerance	16.7%
52	Color blindness	15.8%
53	Ataxia	15.8%
54	Athetosis	15.8%
55	Catalepsy	15.8%
56	Dystonia	15.8%
57	Hemiplegia	15.8%
58	Locked-In Syndrome	15.8%
59	Muscle Hypertonia	15.8%
60	Muscle hypotonia	15.8%
61	Myoclonus	15.8%
62	Myotonia	15.8%
63	Paraplegia	15.8%
64	Pseudobulbar Palsy	15.8%
65	Quadriplegia	15.8%
66	Spasm	15.8%
67	Spastic Paraplegia	15.8%
68	Status Epilepticus	15.8%
69	Tremor	15.8%
70	Monoplegia	15.8%
71	Hypokinesia	15.8%
72	Paraparesis	15.8%
73	Bradykinesia	15.8%
74	Waxy flexibility	15.8%
75	Action Tremor	15.8%
76	Resting Tremor	15.8%
77	Quadriparesis	15.8%
78	Myokymia	15.8%
79	Hyperkinesia	15.8%
80	Intention tremor	15.8%
81	Reflex, Abnormal	15.2%
82	Hyporeflexia	15.2%
83	Hyperreflexia	15.2%
84	Polydipsia	15.2%
85	Akathisia	15%
86	Restlessness	15%
87	Psychomotor Agitation	15%
88	Asthenia	14.9%
89	Body Temperature Changes	14.9%
90	Cyanosis	14.9%
91	Edema	14.9%
92	Failure to Thrive	14.9%
93	Fatigue	14.9%
94	Feminization	14.9%
95	Fetal Distress	14.9%
96	Motion Sickness	14.9%
97	Signs and Symptoms, Digestive	14.9%
98	Signs and Symptoms, Respiratory	14.9%
99	Skin Manifestations	14.9%
100	Chills	14.9%
101	Lassitude	14.9%
102	Pseudophakia	14.9%
103	Urological Manifestations	14.9%
104	Mobility Limitation	14.9%
105	Somnolence	14.9%
106	Abdominal Pain	14.6%
107	Neurogenic Inflammation	14.5%
108	Muscular Atrophy	14.3%
109	Amaurosis Fugax	14%
110	Blindness, Cortical	14%
111	Chorea	13.9%
112	Deafness	13.9%
113	Hearing Loss, Sudden	13.9%
114	Hearing Loss, Bilateral	13.9%
115	Hearing Loss, High-Frequency	13.9%
116	Hearing Loss, Mixed Conductive-Sensorineural	13.9%
117	Hearing Loss, Unilateral	13.9%
118	Complete Hearing Loss	13.9%
119	Deaf Mutism	13.9%
120	Gait Apraxia	13.4%
121	Muscle Weakness	13.4%
122	Renal Colic	13.1%
123	Anisocoria	12.9%
124	Confusion	12.9%
125	Facial paralysis	12.9%
126	Lethargy	12.9%
127	Memory Disorders	12.9%
128	Muscle Cramp	12.9%
129	Perceptual Disorders	12.9%
130	Psychomotor Disorders	12.9%
131	Tonic Pupil	12.9%
132	Anhedonia	12.9%
133	Disorientation	12.9%
134	Facial Paresis	12.9%
135	Memory Loss	12.9%
136	Hemisensory Neglect	12.9%
137	Respiratory Paralysis	12.7%
138	Tetany	12.6%
139	Ophthalmoplegia	12.4%
140	External Ophthalmoplegia	12.4%
141	Eye pain	11.9%
142	Eye Manifestations	11.8%
143	Cerebrospinal Fluid Otorrhea	11.6%
144	Cerebrospinal Fluid Rhinorrhea	11.6%
145	Pain	11.5%
146	Ache	11.5%
147	Cardiac Output, High	11.4%
148	Myocardial Stunning	11.4%
149	Reticulocytosis	11.4%
150	Low Cardiac Output Syndrome	11.4%
151	Back Pain	11.2%
152	Neck Pain	11.2%
153	Chest Pain	11.2%
154	Facial Pain	11.2%
155	Flank Pain	11.2%
156	Headache	11.2%
157	Pain, Intractable	11.2%
158	Pelvic Pain	11.2%
159	Chronic pain	11.2%
160	Pain, Referred	11.2%
161	Throbbing Headache	11.2%
162	Labor Pain	11.2%
163	Cancer Pain	11.2%
164	Nociceptive Pain	11.2%
165	Hoarseness	11.2%
166	Intermittent Claudication	11.1%
167	Dyskinesia, Drug-Induced	11%
168	Neuralgia	10.9%
169	Neuropathic pain	10.9%
170	Consciousness Disorders	10.9%
171	Mental Retardation	10.9%
172	Depressed Level of Consciousness	10.9%
173	Mental deficiency	10.9%
174	Intellectual Disability	10.9%
175	Catatonia	10.7%
176	Vocal Cord Paralysis	10.7%
177	Aphonia	10.6%
178	Dysphonia	10.6%
179	Pain, Postoperative	10.5%
180	Cranial nerve diseases	10.4%
181	Demyelinating Diseases	10.4%
182	Demyelination	10.4%
183	Neuromuscular Diseases	10.4%
184	Chronobiology Disorders	10.4%
185	Language Disorders	10.4%
186	Paraparesis, Spastic	10.4%
187	Trismus	10.4%
188	Epilepsia Partialis Continua	10.4%
189	Brown-Sequard Syndrome	10.4%
190	Lockjaw	10.4%
191	Phantom pain	9.9%
192	Phantom Limb Pain	9.9%
193	Horner Syndrome	9.8%
194	Pathological Conditions, Anatomical	9.8%
195	Cerebellar Ataxia	9.6%
196	Torticollis	9.6%
197	Ophthalmoplegic Migraine	9.6%
198	Sarcopenia	9.3%
199	Tardive Dyskinesia	9.3%
200	Abdomen, Acute	9.2%
201	Alcohol Withdrawal Seizures	9.1%
202	Hypergammaglobulinemia	9.1%
203	Alexia	8.9%
204	Dyslexia	8.9%
205	Gastroparesis	8.5%
206	Muscle Rigidity	8.5%
207	Muscle Spasticity	8.5%
208	Cogwheel Rigidity	8.5%
209	Hemifacial Spasm	8.5%
210	Nuchal Rigidity	8.5%
211	Motor Neuron Disease	8.4%
212	Agnosia	8.4%
213	Apraxias	8.4%
214	Hallucinations	8.4%
215	Visual Agnosia	8.4%
216	Anosognosia	8.4%
217	Wernicke-Korsakoff Syndrome	8.4%
218	Progressive supranuclear palsy	8.3%
219	jaundice	8.2%
220	Trauma, Nervous System	8.1%
221	Anorexia	8.1%
222	Anoxia	8.1%
223	Constipation	8.1%
224	Diarrhea	8.1%
225	Dyspepsia	8.1%
226	Eructation	8.1%
227	Fever	8.1%
228	Flatulence	8.1%
229	Flushing	8.1%
230	Halitosis	8.1%
231	Heartburn	8.1%
232	Hiccough	8.1%
233	Hypercalciuria	8.1%
234	Hypercapnia	8.1%
235	Hyperphagia	8.1%
236	Nausea	8.1%
237	Pallor	8.1%
238	Vomiting	8.1%
239	Hypocapnia	8.1%
240	Dyschezia	8.1%
241	Hypoxia	8.1%
242	Hyperoxia	8.1%
243	Lower Urinary Tract Symptoms	8.1%
244	Hypoxemia	8.1%
245	Urinoma	8.1%
246	Nervous System Neoplasms	7.9%
247	Neurotoxicity Syndromes	7.9%
248	Agraphia	7.8%
249	Anomia	7.8%
250	Cluttering	7.8%
251	Language Development Disorders	7.8%
252	Speech Disorders	7.8%
253	Syncope	7.8%
254	Stupor	7.8%
255	Dysgraphia	7.8%
256	Presyncope	7.8%
257	Dyslalia	7.8%
258	Dysmenorrhea	7.7%
259	Failed Back Surgery Syndrome	7.7%
260	Persistent Vegetative State	7.5%
261	Low Back Pain	7.4%
262	Visceral Pain	7.4%
263	Postoperative Nausea and Vomiting	7.4%
264	Subacute Combined Degeneration	7.4%
265	Sleep Deprivation	7.4%
266	Stiff-Person Syndrome	7.3%
267	Multiple System Atrophy	7.2%
268	Akathisia, Drug-Induced	7.1%
269	Amnesia	7.1%
270	Delirium	7.1%
271	Dissociative Amnesia	7.1%
272	Global Amnesia	7.1%
273	Metatarsalgia	7%
274	Ocular Motility Disorders	7%
275	Cyclophoria	7%
276	Mastodynia	6.8%
277	Eye Hemorrhage	6.8%
278	Jet Lag Syndrome	6.8%
279	Breakthrough Pain	6.8%
280	Restless Legs Syndrome	6.7%
281	Sciatica	6.7%
282	Polyradiculoneuropathy	6.7%
283	Polyradiculoneuritis	6.7%
284	Hemoptysis	6.6%
285	Encephalomyelitis	6.6%
286	Prion Diseases	6.6%
287	Autonomic Dysreflexia	6.6%
288	Complex Regional Pain Syndromes	6.6%
289	Ecchymosis	6.6%
290	Petechiae	6.6%
291	Purpura	6.6%
292	Aphasia	6.4%
293	Articulation Disorders	6.4%
294	Echolalia	6.4%
295	Stuttering	6.4%
296	Dysphasia	6.4%
297	Body Weight	6.3%
298	Dyscalculia	6.3%
299	Apnea	6.2%
300	Cheyne-Stokes Respiration	6.2%
301	Dyspnea	6.2%
302	Hyperventilation	6.2%
303	Mouth Breathing	6.2%
304	Pruritus	6.2%
305	Sneezing	6.2%
306	Erythema	6.2%
307	Necrolytic Migratory Erythema	6.2%
308	Tachypnea	6.2%
309	Gerstmann Syndrome	6.2%
310	Prosopagnosia	6.2%
311	Apraxia, Ideomotor	6.2%
312	Charles Bonnet Syndrome	6.2%
313	Alien Hand Syndrome	6.2%
314	Vascular Remodeling	6.1%
315	Edema, Cardiac	6.1%
316	Mental Fatigue	6.1%
317	Hirsutism	6.1%
318	Hypoventilation	6.1%
319	Auditory Perceptual Disorders	6.1%
320	Body Weight Changes	6%
321	Brain Death	6%
322	Spinal Muscular Atrophy	5.9%
323	Progressive Muscular Atrophy	5.9%
324	Amnesia, Transient Global	5.9%
325	Dysarthria	5.8%
326	Musculoskeletal Pain	5.8%
327	Marchiafava-Bignami Disease	5.8%
328	Toothache	5.7%
329	Arthralgia	5.7%
330	Polyarthralgia	5.7%
331	Amyotrophic Lateral Sclerosis	5.6%
332	Epistaxis	5.6%
333	Parkinson Disease	5.6%
334	Spinal Cord Injuries	5.5%
335	Brain Diseases	5.5%
336	Dysautonomia	5.5%
337	Meningitis	5.5%
338	Movement Disorders	5.5%
339	Pachymeningitis	5.5%
340	Spinal Cord Diseases	5.5%
341	Vagus Nerve Disorder	5.5%
342	Glossopharyngeal Neuralgia	5.5%
343	Abducens Nerve Diseases	5.5%
344	Heavy Metal Poisoning, Nervous System	5.5%
345	Neuromuscular Junction Diseases	5.5%
346	Tauopathies	5.5%
347	Trochlear Nerve Diseases	5.5%
348	Peripheral Nervous System Diseases	5.5%
349	Opsoclonus-Myoclonus Syndrome	5.5%
350	Meningoencephalitis	5.4%
351	Peripheral Nerve Injuries	5.4%
352	Myasthenia Gravis	5.3%
353	Mutism	5.3%
354	Selective Mutism	5.3%
355	Retrograde amnesia	5.2%
356	Amnesia, Anterograde	5.2%
357	Pleural Rub	5%
358	Rales	5%
359	Respiratory Sounds	5%
360	Rhonchi	5%
361	Stridor	5%
362	Wheezing	5%
363	Ascites	5%
364	Calculi	5%
365	Fibrosis	5%
366	Gliosis	5%
367	Growth Disorders	5%
368	Hemorrhage	5%
369	Hernia	5%
370	Hyperbilirubinemia	5%
371	Hyperplasia	5%
372	Hypertrophy	5%
373	Hypomenorrhea	5%
374	Inflammation	5%
375	Intraoperative Complications	5%
376	Ischemia	5%
377	Lithiasis	5%
378	Malacoplakia	5%
379	Menstruation Disturbances	5%
380	Metaplasia	5%
381	Nails, Malformed	5%
382	Nerve Degeneration	5%
383	Ochronosis	5%
384	Polymenorrhea	5%
385	polyps	5%
386	Postoperative Complications	5%
387	Rupture, Spontaneous	5%
388	Sclerosis	5%
389	Shock	5%
390	Ulcer	5%
391	Enterocele	5%
392	Hyperammonemia	5%
393	Hyperamylasemia	5%
394	Teratogenesis	5%
395	Atheroma	5%
396	Cardiac Death	5%
397	Hypovolemia	5%
398	Hyperuricemia	5%
399	Leukoaraiosis	5%
400	Stenosis	5%
401	Facial asymmetry	5%
402	Dysbacteriosis	5%
403	Delayed Graft Function	5%
404	Cirrhosis	5%
405	Plaque, Amyloid	5%
406	Plaque, Atherosclerotic	5%
407	Neointima	5%
408	Dysbiosis	5%
409	Dandy-Walker Syndrome	4.9%
410	Livedo Reticularis	4.9%
411	Lewy Body Disease	4.9%
412	Pneumocephalus	4.9%
413	Poliomyelitis	4.9%
414	Myelitis	4.9%
415	Progressive bulbar palsy	4.9%
416	Bulbar palsy	4.9%
417	Oliguria	4.9%
418	Polyuria	4.9%
419	Proteinuria	4.9%
420	Guillain-Barre Syndrome	4.9%
421	Jaundice, Obstructive	4.8%
422	Bulimia	4.8%
423	Dysuria	4.8%
424	Fever of Unknown Origin	4.8%
425	Nocturia	4.8%
426	Snoring	4.8%
427	Prostatism	4.8%
428	Underweight	4.8%
429	Overweight	4.8%
430	Alexia, Pure	4.7%
431	Myalgia	4.7%
432	Chronic Fatigue Syndrome	4.6%
433	Neuroleptic Malignant Syndrome	4.6%
434	Myelinolysis, Central Pontine	4.6%
435	Sleep Disorders, Circadian Rhythm	4.6%
436	Striatonigral Degeneration	4.6%
437	Lambert-Eaton Myasthenic Syndrome	4.6%
438	Angina Pectoris	4.5%
439	Causalgia	4.5%
440	Botulism	4.4%
441	Central Nervous System Cysts	4.4%
442	Coma, Post-Head Injury	4.4%
443	Central Nervous System Infection	4.4%
444	Myopathy	4.4%
445	Optic Neuropathy	4.4%
446	Epidural Abscess	4.3%
447	Olfactory Nerve Injuries	4.3%
448	Myelitis, Transverse	4.2%
449	Facial Nerve Diseases	4.2%
450	Craniocerebral Trauma	4.2%
451	Parasomnia	4.2%
452	Dyssomnias	4.2%
453	MPTP Poisoning	4.2%
454	Gagging	4.2%
455	Vestibulocochlear Nerve Diseases	4.1%
456	Hydranencephaly	4.1%
457	Neural Tube Defects	4.1%
458	Tethered Cord Syndrome	4.1%
459	Central Nervous System Neoplasms	4.1%
460	Iniencephaly	4.1%
461	Craniorachischisis	4.1%
462	Exencephaly	4.1%
463	Septo-Optic Dysplasia	4.1%
464	Cortical Dysplasia	4.1%
465	Malformations of Cortical Development	4.1%
466	Sweating, Gustatory	4.1%
467	Auriculotemporal Syndrome	4.1%
468	Leukoencephalitis, Acute Hemorrhagic	4.1%
469	Infarction	4.1%
470	Postoperative Hemorrhage	4.1%
471	Shock, Hemorrhagic	4.1%
472	Systemic Inflammatory Response Syndrome	4.1%
473	Incisional hernia	4.1%
474	Encephalomyelitis, Acute Disseminated	4.1%
475	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.1%
476	Reflex Sympathetic Dystrophy	4%
477	Subdural Effusion	4%
478	Parkinsonian Disorders	4%
479	Nocturnal Myoclonus Syndrome	4%
480	Miller Fisher Syndrome	4%
481	Shy-Drager Syndrome	3.9%
482	Brain Injuries	3.9%
483	Cyst	3.9%
484	Extravasation of Diagnostic and Therapeutic Materials	3.9%
485	Neoplastic Processes	3.9%
486	Brain Neoplasms	3.9%
487	Multiple Sclerosis	3.9%
488	Spinal Cord Neoplasms	3.9%
489	Neuromyelitis Optica	3.9%
490	Hematemesis	3.9%
491	Purpura Fulminans	3.9%
492	Leukoplakia	3.8%
493	Necrosis	3.8%
494	Granulomatosis, Orofacial	3.8%
495	Pigmentation Disorders	3.8%
496	Respiratory Aspiration	3.8%
497	Airway Remodeling	3.8%
498	Dystonia Musculorum Deformans	3.8%
499	Shoulder Pain	3.7%
500	Acantholysis	3.7%
501	Chromosome Aberrations	3.7%
502	Dehydration	3.7%
503	Granuloma	3.7%
504	Leukocytosis	3.7%
505	Pleocytosis	3.7%
506	Ventricular Remodeling	3.7%
507	Facial Nerve Injuries	3.7%
508	Alopecia	3.7%
509	Ataxia Telangiectasia	3.7%
510	Androgenetic Alopecia	3.7%
511	Morning Sickness	3.7%
512	Weight Gain	3.6%
513	Meningocele	3.6%
514	Encephalocele	3.6%
515	Birth Weight	3.4%
516	Kearns-Sayre syndrome	3.4%
517	Leukoencephalopathy, Progressive Multifocal	3.4%
518	Paraneoplastic Encephalomyelitis	3.4%
519	Angina, Unstable	3.4%
520	Uveomeningoencephalitic Syndrome	3.3%
521	Vasculitis, Central Nervous System	3.3%
522	Brain Abscess	3.3%
523	Scrapie	3.3%
524	Sturge-Weber Syndrome	3.3%
525	Central Cord Syndrome	3.3%
526	Alcohol-Induced Disorders, Nervous System	3.3%
527	Cri-du-Chat Syndrome	3.3%
528	Down Syndrome	3.3%
529	Trisomy 21	3.3%
530	Presenile dementia	3.3%
531	Senile dementia	3.3%
532	Meningitis, Bacterial	3.3%
533	Meningitis, Fungal	3.3%
534	Limbic Encephalitis	3.2%
535	Myasthenia Gravis, Autoimmune, Experimental	3.2%
536	Akinetic Mutism	3.2%
537	Anoxic Encephalopathy	3.2%
538	Arachnoiditis	3.2%
539	Basal Ganglia Diseases	3.2%
540	Brain Damage, Chronic	3.2%
541	Cerebellar Diseases	3.2%
542	Encephalitis	3.2%
543	Encephalomalacia	3.2%
544	Epilepsy	3.2%
545	Hydrocephalus	3.2%
546	Congenital Hydrocephalus	3.2%
547	Hypothalamic Diseases	3.2%
548	Aseptic Meningitis	3.2%
549	Neuritis	3.2%
550	Polyneuritis	3.2%
551	Radiculitis	3.2%
552	Syringomyelia	3.2%
553	Thalamic Diseases	3.2%
554	Intracranial Hypertension	3.2%
555	Polyneuropathy	3.2%
556	Williams Syndrome	3.2%
557	Mononeuritis	3.2%
558	Aura	3.2%
559	Leukoencephalopathy	3.2%
560	Essential Tremor	3.2%
561	Neuroaxonal Dystrophies	3.2%
562	Familial Tremor	3.2%
563	Headache Disorders	3.2%
564	Mononeuropathies	3.2%
565	Intracranial Hypotension	3.2%
566	Brachial Plexus Neuropathies	3.2%
567	Radiculopathy	3.2%
568	Mononeuropathy Multiplex	3.2%
569	Nerve Root Compression	3.2%
570	Brain Edema	3.2%
571	Brain Hypoxia	3.2%
572	Aqueductal Stenosis	3.2%
573	Pneumorrhachis	3.2%
574	Writer's Cramp	3.2%
575	Acrodynia	3.2%
576	Epilepsy, Post-Traumatic	3.2%
577	Meige Syndrome	3.2%
578	Brachial Plexus Neuritis	3.2%
579	Neuralgic Amyotrophy	3.2%
580	Cerebral Ventriculitis	3.2%
581	Emaciation	3.2%
582	Genomic Instability	3.1%
583	Huntington Disease	3.1%
584	Tuberous Sclerosis	3.1%
585	Charcot-Marie-Tooth Disease	3%
586	Fetal Hypoxia	3%
587	Diverticulum	3%
588	Diverticulosis	3%
589	Azotemia	2.9%
590	Dyspnea, Paroxysmal	2.9%
591	Urinary Incontinence	2.9%
592	Albuminuria	2.9%
593	Hemoglobinuria	2.9%
594	Rett Syndrome	2.9%
595	Lupus Vasculitis, Central Nervous System	2.9%
596	Thrombocytopenic purpura	2.8%
597	Canavan Disease	2.8%
598	Alexander Disease	2.8%
599	Lafora Disease	2.8%
600	Unverricht-Lundborg Syndrome	2.8%
601	Tarsal Tunnel Syndrome	2.8%
602	Cauda Equina Syndrome	2.8%
603	Posterior Leukoencephalopathy Syndrome	2.8%
604	Posterior reversible encephalopathy syndrome	2.8%
605	Prader-Willi Syndrome	2.8%
606	Angina Pectoris, Variant	2.8%
607	Purpura, Hyperglobulinemic	2.8%
608	Smith-Magenis syndrome	2.8%
609	Dural Arteriovenous Fistula	2.8%
610	Chromosomal Instability	2.8%
611	Hydrops Fetalis	2.7%
612	Myotonia Congenita	2.7%
613	Paraneoplastic Cerebellar Degeneration	2.7%
614	Acute Disease	2.7%
615	Acute-Phase Reaction	2.7%
616	Amenorrhea	2.7%
617	Chronic disease	2.7%
618	Critical Illness	2.7%
619	Sudden death	2.7%
620	Fat necrosis	2.7%
621	Gangrene	2.7%
622	Graft Occlusion, Vascular	2.7%
623	Granuloma, Plasma Cell	2.7%
624	Hematoma	2.7%
625	Diaphragmatic Hernia	2.7%
626	Iatrogenic Disease	2.7%
627	Intestinal Polyps	2.7%
628	Multiple Organ Failure	2.7%
629	Oligomenorrhea	2.7%
630	Premenstrual syndrome	2.7%
631	Recurrence	2.7%
632	Retrograde Degeneration	2.7%
633	Retroperitoneal fibrosis	2.7%
634	Serositis	2.7%
635	Splenomegaly	2.7%
636	Subcutaneous Emphysema	2.7%
637	Surgical Wound Dehiscence	2.7%
638	Syndrome	2.7%
639	Wallerian Degeneration	2.7%
640	Pyogenic granuloma	2.7%
641	Exsanguination	2.7%
642	Disease Progression	2.7%
643	Seroma	2.7%
644	Premenstrual Tension	2.7%
645	Delayed Emergence from Anesthesia	2.7%
646	Infant Death	2.7%
647	Anastomotic Leak	2.7%
648	Intraoperative Awareness	2.7%
649	Neuritis, Autoimmune, Experimental	2.7%
650	Fetal Weight	2.7%
651	Cerebellar Neoplasms	2.7%
652	Creutzfeldt-Jakob disease	2.6%
653	Basal Ganglia Cerebrovascular Disease	2.6%
654	Dementia, Vascular	2.6%
655	Brain Hemorrhage, Traumatic	2.6%
656	Menorrhagia	2.6%
657	Brain Injuries, Diffuse	2.6%
658	Traumatic Brain Injury	2.6%
659	Supratentorial Neoplasms	2.6%
660	Multiple Sclerosis, Chronic Progressive	2.6%
661	Multiple Sclerosis, Relapsing-Remitting	2.6%
662	Waterhouse-Friderichsen Syndrome	2.6%
663	Cardiotoxicity	2.5%
664	Friedreich Ataxia	2.5%
665	Hematoma, Subdural	2.5%
666	Hematoma, Epidural, Cranial	2.5%
667	Brain Diseases, Metabolic	2.5%
668	Cerebrovascular Disorders	2.5%
669	Myositis	2.5%
670	Optic Atrophy	2.5%
671	Optic Neuritis	2.5%
672	Papilledema	2.5%
673	Strabismus	2.5%
674	Tolosa-Hunt Syndrome	2.5%
675	Cerebrovascular Insufficiency	2.5%
676	Isaacs syndrome	2.5%
677	Arsenic Poisoning	2.5%
678	Dementia	2.5%
679	Myotonic Disorders	2.5%
680	Central Nervous System Fungal Infections	2.5%
681	Conus Medullaris Syndrome	2.5%
682	Myasthenic Syndromes, Congenital	2.5%
683	Spinal Cord Vascular Diseases	2.5%
684	Diabetic Neuropathies	2.4%
685	Facial Injuries	2.4%
686	Facial Neuralgia	2.4%
687	Diabetic Amyotrophy	2.4%
688	Diabetic Autonomic Neuropathy	2.4%
689	Sleep Talking	2.4%
690	Manganese Poisoning	2.4%
691	Sleep Disorders, Intrinsic	2.4%
692	Meningeal Neoplasms	2.4%
693	Meningomyelocele	2.4%
694	Spina Bifida	2.4%
695	Mercury Poisoning, Nervous System	2.4%
696	Lead Poisoning, Nervous System	2.4%
697	Vestibular Neuronitis	2.4%
698	Carotid Artery Injuries	2.4%
699	Hyperemesis Gravidarum	2.4%
700	Sudden infant death syndrome	2.4%
701	Obesity	2.4%
702	Myoclonic Epilepsy	2.4%
703	Epilepsy, Temporal Lobe	2.4%
704	Epilepsy, Rolandic	2.4%
705	Benign Rolandic Epilepsy	2.4%
706	Cachexia	2.4%
707	Hepatolenticular Degeneration	2.4%
708	Myotonic Dystrophy	2.4%
709	Tuberculosis, Meningeal	2.3%
710	Carpal Tunnel Syndrome	2.3%
711	Vascular Headaches	2.3%
712	neurofibroma	2.2%
713	Hypoxia-Ischemia, Brain	2.2%
714	Rubinstein-Taybi Syndrome	2.2%
715	Leukomalacia, Periventricular	2.2%
716	Asphyxia	2.1%
717	Granuloma, Respiratory Tract	2.1%
718	Shock, Traumatic	2.1%
719	Respiratory Tract Fistula	2.1%
720	Cerebral Palsy	2.1%
721	Epilepsies, Partial	2.1%
722	Epilepsy, Generalized	2.1%
723	Pseudotumor Cerebri	2.1%
724	Sciatic Neuropathy	2.1%
725	Hypertensive Encephalopathy	2.1%
726	Ulnar Neuropathies	2.1%
727	Lesion of Sciatic Nerve	2.1%
728	Simple Partial Seizures	2.1%
729	Epilepsy, Reflex	2.1%
730	Ulnar Neuritis	2.1%
731	Radial nerve compression	2.1%
732	Radial Tunnel Syndrome	2.1%
733	Peroneal Neuropathies	2.1%
734	Radial Neuropathy	2.1%
735	Median Neuropathy	2.1%
736	Sciatic Nerve Palsy	2.1%
737	Femoral Neuropathy	2.1%
738	Tibial Neuropathy	2.1%
739	Ulnar Nerve Palsy	2.1%
740	Postural Orthostatic Tachycardia Syndrome	2.1%
741	Radial nerve palsy	2.1%
742	Headache Disorders, Primary	2.1%
743	Headache Disorders, Secondary	2.1%
744	Medication overuse headache	2.1%
745	Adrenoleukodystrophy	2.1%
746	Basal Ganglia Hemorrhage	2.1%
747	Vertebral Artery Dissection	2.1%
748	Hand-Arm Vibration Syndrome	2.1%
749	Disease susceptibility	2.1%
750	Fetal Death	2.1%
751	Foreign-Body Reaction	2.1%
752	Gastrointestinal Hemorrhage	2.1%
753	Cardiomegaly	2.1%
754	Hemarthrosis	2.1%
755	Hemoperitoneum	2.1%
756	Hemothorax	2.1%
757	Hepatomegaly	2.1%
758	Neoplasm Invasiveness	2.1%
759	Neoplasm Metastasis	2.1%
760	Neoplasm Recurrence, Local	2.1%
761	Parovarian Cyst	2.1%
762	Postpericardiotomy Syndrome	2.1%
763	Prosthesis Failure	2.1%
764	Reperfusion Injury	2.1%
765	Spermatocele	2.1%
766	Oral Fistula	2.1%
767	Injection Site Reaction	2.1%
768	Retrobulbar Hemorrhage	2.1%
769	Cutaneous Fistula	2.1%
770	Aseptic Necrosis of Bone	2.1%
771	Peritoneal Fibrosis	2.1%
772	Carcinogenesis	2.1%
773	Perinatal death	2.1%
774	Infusion site reaction	2.1%
775	Cardiac Hypertrophy	2.1%
776	Nephrogenic Fibrosing Dermopathy	2.1%
777	Corneal Endothelial Cell Loss	2.1%
778	Encapsulating Peritoneal Sclerosis	2.1%
779	Vasoplegia	2.1%
780	Suppuration	2.1%
781	Nephrogenic Systemic Fibrosis	2.1%
782	Metastasis	2.1%
783	Fragile X Syndrome	2.1%
784	Tinea Pedis	2.1%
785	Sinus Arrhythmia	2%
786	Atrial Fibrillation	2%
787	Atrial Flutter	2%
788	Dental Pulp Necrosis	2%
789	Granuloma, Foreign-Body	2%
790	Mediastinal Emphysema	2%
791	Surgical Wound Infection	2%
792	Ventricular Fibrillation	2%
793	Ventricular Flutter	2%
794	Parasystole	2%
795	Paroxysmal atrial fibrillation	2%
796	Facies	2%
797	Bradycardia	2%
798	Embryo Loss	2%
799	Afferent Loop Syndrome	2%
800	Sex Chromosome Aberrations	2%
801	Short Bowel Syndrome	2%
802	Uterine hemorrhage	2%
803	Vaginal Fistula	2%
804	Rectocele	2%
805	No-Reflow Phenomenon	2%
806	Fibromyalgia	2%
807	Optic Neuropathy, Ischemic	2%
808	Anterior Ischemic Optic Neuropathy	2%
809	Central Nervous System Bacterial Infections	2%
810	Medial Tibial Stress Syndrome	2%
811	Brain Concussion	2%
812	Optic Nerve Glioma	2%
813	Facial Hemiatrophy	2%
814	Melkersson-Rosenthal Syndrome	2%
815	Mitochondrial Myopathies	2%
816	Juvenile Myoclonic Epilepsy	2%
817	Myoclonic Epilepsies, Progressive	2%
818	Refsum Disease	2%
819	Eosinophilia-Myalgia Syndrome	2%
820	Toxoplasmosis, Cerebral	2%
821	Sleep Bruxism	2%
822	Anencephaly	2%
823	Subarachnoid Hemorrhage	1.9%
824	Cerebral Hemorrhage	1.9%
825	Alstrom Syndrome	1.9%
826	Urge Incontinence	1.9%
827	Cubital Tunnel Syndrome	1.9%
828	Diffuse Axonal Injury	1.9%
829	Brain Stem Neoplasms	1.9%
830	Meningitis, Cryptococcal	1.9%
831	Meningitis, Listeria	1.9%
832	Meningitis, Haemophilus	1.9%
833	Meningitis, Pneumococcal	1.9%
834	Frontotemporal dementia	1.9%
835	Kernicterus	1.9%
836	Mitochondrial Encephalomyopathies	1.9%
837	Hematoma, Subdural, Intracranial	1.8%
838	Hematoma, Subdural, Chronic	1.8%
839	Hematoma, Subdural, Acute	1.8%
840	Purpura, Thrombotic Thrombocytopenic	1.8%
841	Amyloid Neuropathies, Familial	1.8%
842	Pituitary Adenoma	1.8%
843	Pituitary Neoplasms	1.8%
844	Acoustic Neuroma	1.8%
845	Putaminal Hemorrhage	1.7%
846	Drowning	1.7%
847	Pituitary Diseases	1.7%
848	Nasal Polyps	1.7%
849	Duane Retraction Syndrome	1.7%
850	Mobius Syndrome	1.7%
851	Bell Palsy	1.7%
852	Fetal Growth Retardation	1.7%
853	DNA Degradation, Necrotic	1.7%
854	Aneuploidy	1.7%
855	Polyploidy	1.7%
856	Microsatellite Instability	1.7%
857	Herpes Zoster Oticus	1.6%
858	Thoracic Outlet Syndrome	1.6%
859	Familial Periodic Paralysis	1.6%
860	Heart Block	1.6%
861	Tachycardia	1.6%
862	Tachyarrhythmia	1.6%
863	Cicatrix	1.6%
864	Hematuria	1.6%
865	Urinary Calculi	1.6%
866	Granuloma Annulare	1.6%
867	Chromosome Breakage	1.6%
868	Pituitary Apoplexy	1.6%
869	Carotid Artery Diseases	1.6%
870	Brain Ischemia	1.6%
871	Esotropia	1.6%
872	Exotropia	1.6%
873	Hypotension, Orthostatic	1.6%
874	Sleep Apnea Syndromes	1.6%
875	Cerebrovascular accident	1.6%
876	Polymyositis	1.6%
877	Kluver-Bucy Syndrome	1.6%
878	Vasospasm, Intracranial	1.6%
879	Spinal Cord Ischemia	1.6%
880	Intracranial Arterial Diseases	1.6%
881	Post-Exercise Hypotension	1.6%
882	Giant Cell Arteritis	1.6%
883	Temporal Arteritis	1.6%
884	Shock, Cardiogenic	1.6%
885	Chromosome Fragility	1.6%
886	Endotoxic shock	1.6%
887	Septic Shock	1.6%
888	Toxic Shock Syndrome	1.6%
889	Menkes Kinky Hair Syndrome	1.6%
890	Disorders of Excessive Somnolence	1.6%
891	Sleep Initiation and Maintenance Disorders	1.6%
892	Night Terrors	1.6%
893	Somnambulism	1.6%
894	Trigeminal Nerve Disorder	1.6%
895	Transient Insomnia	1.6%
896	Sleep Paralysis	1.6%
897	Chronic Insomnia	1.6%
898	REM Sleep Behavior Disorder	1.6%
899	Hypersomnia	1.6%
900	Tissue Adhesions	1.6%
901	Colonic Polyps	1.6%
902	Brain Contusion	1.6%
903	Hematoma, Epidural, Spinal	1.6%
904	Dermal Sinus	1.6%
905	Spina Bifida Cystica	1.6%
906	Spina Bifida Occulta	1.6%
907	Meningeal Carcinomatosis	1.6%
908	Lissencephaly	1.6%
909	Polymicrogyria	1.6%
910	Pachygyria	1.6%
911	Schizencephaly	1.6%
912	Lead Poisoning, Nervous System, Childhood	1.6%
913	Lead Poisoning, Nervous System, Adult	1.6%
914	Brain Infarction	1.6%
915	Periventricular Nodular Heterotopia	1.6%
916	Tuberculosis, Central Nervous System	1.6%
917	Classical Lissencephalies and Subcortical Band Heterotopias	1.6%
918	Polyradiculopathy	1.6%
919	Post-Traumatic Headache	1.6%
920	Tension Headache	1.6%
921	Epilepsy, Complex Partial	1.6%
922	Migraine Disorders	1.6%
923	Abdominal Migraine	1.6%
924	Status Migrainosus	1.6%
925	Cervicogenic Headache	1.6%
926	Subarachnoid Hemorrhage, Traumatic	1.6%
927	Carotid Artery, Internal, Dissection	1.6%
928	Pediatric Obesity	1.6%
929	Choroid Plexus Papilloma	1.6%
930	Subacute Sclerosing Panencephalitis	1.5%
931	Autoimmune thrombocytopenia	1.5%
932	Immune thrombocytopenic purpura	1.5%
933	Mucopolysaccharidosis II	1.4%
934	Giant Cell Epulis	1.4%
935	Neuronal Ceroid-Lipofuscinoses	1.4%
936	Infarction, Middle Cerebral Artery	1.4%
937	Infarction, Anterior Cerebral Artery	1.4%
938	Infarction, Posterior Cerebral Artery	1.4%
939	Sick Sinus Syndrome	1.4%
940	Trisomy	1.4%
941	Leukoplakia, Oral	1.4%
942	Long QT Syndrome	1.4%
943	Eye Injuries	1.3%
944	Micronuclei, Chromosome-Defective	1.3%
945	Cluster Headache	1.3%
946	Migraine with Aura	1.3%
947	Familial Hemiplegic Migraine	1.3%
948	Chronic Paroxysmal Hemicrania	1.3%
949	SUNCT Syndrome	1.3%
950	Paroxysmal Hemicrania	1.3%
951	Cerebral Infarction	1.3%
952	Brain Stem Infarctions	1.3%
953	Muscular Dystrophy	1.3%
954	Congenital nystagmus	1.3%
955	Orbital Myositis	1.3%
956	MELAS Syndrome	1.3%
957	Reye Syndrome	1.3%
958	Neuroaspergillosis	1.3%
959	Pyomyositis	1.3%
960	Intracranial Embolism and Thrombosis	1.3%
961	Hepatic Encephalopathy	1.3%
962	Moyamoya Disease	1.3%
963	Optic Atrophy, Hereditary, Leber	1.3%
964	Aicardi's syndrome	1.3%
965	Neurofibrosarcoma	1.2%
966	Biliary Fistula	1.2%
967	Cross Infection	1.2%
968	Gastric Fistula	1.2%
969	Hyphema	1.2%
970	Retinal Neovascularization	1.2%
971	Septicemia	1.2%
972	Vitreous Hemorrhage	1.2%
973	Congenital diaphragmatic hernia	1.2%
974	Sepsis	1.2%
975	Cockayne Syndrome	1.2%
976	Empty Sella Syndrome	1.2%
977	Hyperpituitarism	1.2%
978	Hypopituitarism	1.2%
979	Hypophysitis	1.2%
980	Alcohol Withdrawal Delirium	1.2%
981	Abscess	1.2%
982	Dental Fistula	1.2%
983	Empyema	1.2%
984	Femur Head Necrosis	1.2%
985	Fetal Resorption	1.2%
986	Lymphatic Metastasis	1.2%
987	Neoplasms, Unknown Primary	1.2%
988	Oroantral Fistula	1.2%
989	Peptic Ulcer Hemorrhage	1.2%
990	Sudden Cardiac Death	1.2%
991	Left Ventricular Hypertrophy	1.2%
992	Leukemic Infiltration	1.2%
993	Right Ventricular Hypertrophy	1.2%
994	Premenstrual Dysphoric Disorder	1.2%
995	Choroidal Neovascularization	1.2%
996	Primary Graft Dysfunction	1.2%
997	Neoplasm Micrometastasis	1.2%
998	Dumping Syndrome	1.2%
999	Rectal Prolapse	1.2%
1000	Uterine Prolapse	1.2%
1001	Cicatrix, Hypertrophic	1.2%
1002	Vaginal Prolapse	1.2%
1003	Sinus Arrest, Cardiac	1.2%
1004	Cerebral Arterial Diseases	1.2%
1005	Metrorrhagia	1.2%
1006	Vertebrobasilar Insufficiency	1.2%
1007	Anterior Spinal Artery Syndrome	1.2%
1008	Basilar Artery Stenosis	1.2%
1009	Vertebral Artery Stenosis	1.2%
1010	Sleep Apnea, Obstructive	1.2%
1011	Sleep Apnea, Central	1.2%
1012	Intracranial Hemorrhage, Hypertensive	1.2%
1013	Transient Cerebral Ischemia	1.2%
1014	Narcolepsy	1.2%
1015	Trigeminal Neuralgia	1.2%
1016	Kleine-Levin Syndrome	1.2%
1017	Lateral Medullary Syndrome	1.2%
1018	Eosinophilic Granuloma	1.2%
1019	West Nile Fever	1.2%
1020	Pseudorabies	1.1%
1021	Vesicovaginal Fistula	1.1%
1022	Holoprosencephaly	1.1%
1023	Brain Diseases, Metabolic, Inborn	1.1%
1024	POEMS Syndrome	1.1%
1025	Meningioma	1.1%
1026	Microcephaly	1.1%
1027	Macrocephaly	1.1%
1028	Neurosyphilis	1.1%
1029	Hypokalemic periodic paralysis	1.1%
1030	Porencephaly	1.1%
1031	Hematoma, Subdural, Spinal	1.1%
1032	Hyperprolactinemia	1%
1033	Bronchial Fistula	1%
1034	Pancreatic Fistula	1%
1035	Retinal Hemorrhage	1%
1036	Subclavian Steal Syndrome	1%
1037	Pick Disease of the Brain	1%
1038	Cataplexy	1%
1039	Choroid Hemorrhage	1%
1040	Intestinal Fistula	1%
1041	Melena	1%
1042	Gastroschisis	1%
1043	Enterocutaneous Fistula	1%
1044	Toxoplasmosis, Congenital	1%
1045	Eye Burns	1%
1046	Postpartum Hemorrhage	1%
1047	Salivary Gland Fistula	1%
1048	Malaria, Cerebral	1%
1049	Cystocele	1%
1050	Gingival Hemorrhage	1%
1051	Keloid	1%
1052	Carotid Stenosis	1%
1053	Intracranial Aneurysm	1%
1054	Monosomy	1%
1055	Welander Distal Myopathy	1%
1056	Tetraploidy	1%
1057	Stillbirth	1%
1058	Adams-Stokes Syndrome	1%
1059	Atrioventricular Block	1%
1060	Bundle-Branch Block	1%
1061	Atrial Premature Complexes	1%
1062	Sinoatrial Block	1%
1063	Tachycardia, Paroxysmal	1%
1064	Supraventricular tachycardia	1%
1065	Tachycardia, Ventricular	1%
1066	Tachycardia, Reciprocating	1%
1067	Neurocysticercosis	1%
1068	Intracranial Arteriosclerosis	1%
1069	Cerebral Atherosclerosis	1%
1070	Cerebral Arteriosclerosis	1%
1071	Cerebral Thrombosis	1%
1072	Intracranial Embolism	1%
1073	Intracranial Thrombosis	1%
1074	Wernicke Encephalopathy	0.9%
1075	AIDS Dementia Complex	0.9%
1076	Lyme Neuroborreliosis	0.9%
1077	Viremia	0.8%
1078	Parasitemia	0.8%
1079	Dermatomyositis	0.8%
1080	Cellulitis	0.8%
1081	Corneal Scar	0.8%
1082	Umbilical hernia	0.8%
1083	Muscular Dystrophy, Duchenne	0.8%
1084	Acromegaly	0.8%
1085	Romano-Ward Syndrome	0.8%
1086	Carotid Artery Thrombosis	0.8%
1087	Cerebral Amyloid Angiopathy	0.8%
1088	Sinus Thrombosis, Intracranial	0.8%
1089	Granuloma, Laryngeal	0.7%
1090	Cavernous Sinus Thrombosis	0.7%
1091	Sagittal Sinus Thrombosis	0.7%
1092	Myocardial Reperfusion Injury	0.7%
1093	Urinary Bladder Fistula	0.7%
1094	Corneal Perforation	0.7%
1095	Bacteremia	0.7%
1096	Cell Transformation, Viral	0.7%
1097	Fungemia	0.6%
1098	Tachycardia, Atrioventricular Nodal Reentry	0.6%
1099	Tachycardia, Ectopic Atrial	0.6%
1100	Tachycardia, Ectopic Junctional	0.6%
1101	Sinus Tachycardia	0.6%
1102	Torsades de Pointes	0.6%
1103	Accelerated Idioventricular Rhythm	0.6%
1104	Arteriovenous fistula	0.6%
1105	Galactosemias	0.6%
1106	Urea Cycle Disorders, Inborn	0.6%
1107	Tyrosinemias	0.6%
1108	Nelson Syndrome	0.6%
1109	Fabry Disease	0.6%
1110	Philadelphia Chromosome	0.6%
1111	Prolactinoma	0.6%
1112	Growth Hormone-Secreting Pituitary Adenoma	0.6%
1113	Homocystinuria	0.5%
1114	Rectal Fistula	0.5%
1115	Anal Fistula	0.5%
1116	Leigh Disease	0.5%
1117	Kidney Calculi	0.5%
1118	Ureteral Calculi	0.5%
1119	Endotoxemia	0.5%
1120	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.4%
1121	Zellweger Syndrome	0.4%
1122	Glycogen storage disease type II	0.4%
1123	Candidemia	0.3%
1124	Gaucher Disease	0.3%
1125	Tay-Sachs Disease	0.3%
1126	Niemann-Pick Disease, Type C	0.3%

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