MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Nocturnal Myoclonus Syndrome

(UMLS:C0751774)

Definition:: Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)
UMLS ID:: C0751774
MeSH ID:: D020189

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.886.425.800.600|C10.886.659.618

Synonym(s)

Nocturnal Myoclonus Syndrome

Periodic limb movement disorder

disorder limb movement periodic

nocturnal myoclonus syndrome

periodic limb movement disorder

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Levodopa	9295178	CTD
2	Olanzapine	10505594	CTD
3	Pergolide	9295178 10947026 14592347	CTD
4	carbidopa, levodopa drug combination	14592347	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Restless Legs Syndrome	45.9%
2	Sleep Apnea Syndromes	32%
3	Disorders of Excessive Somnolence	31.7%
4	Sleep Initiation and Maintenance Disorders	31.7%
5	Transient Insomnia	31.7%
6	Chronic Insomnia	31.7%
7	Hypersomnia	31.7%
8	Sleep Talking	30.6%
9	Sleep Disorders, Circadian Rhythm	25.4%
10	Sleep Bruxism	24.5%
11	Sleep Apnea, Obstructive	24.3%
12	Sleep Apnea, Central	24.3%
13	Narcolepsy	24.2%
14	Kleine-Levin Syndrome	24.2%
15	Cranial nerve diseases	22.4%
16	Demyelinating Diseases	22.4%
17	Demyelination	22.4%
18	Neuromuscular Diseases	22.4%
19	Chronobiology Disorders	22.4%
20	Night Terrors	22%
21	Somnambulism	22%
22	Sleep Paralysis	22%
23	REM Sleep Behavior Disorder	22%
24	Cataplexy	20.5%
25	Motor Neuron Disease	18.8%
26	Sleep Deprivation	18.1%
27	Trauma, Nervous System	17.4%
28	Nervous System Neoplasms	16.8%
29	Neurologic Manifestations	16.8%
30	Neurotoxicity Syndromes	16.8%
31	Multiple System Atrophy	16.7%
32	Stiff-Person Syndrome	16.4%
33	Jet Lag Syndrome	16.1%
34	Ocular Motility Disorders	15.6%
35	Cyclophoria	15.6%
36	Dyssomnias	15.4%
37	Polyradiculoneuropathy	15.2%
38	Polyradiculoneuritis	15.2%
39	Encephalomyelitis	15.1%
40	Prion Diseases	15.1%
41	Autonomic Dysreflexia	15.1%
42	Complex Regional Pain Syndromes	15.1%
43	Nocturnal Myoclonus Syndrome	14.8%
44	Spinal Muscular Atrophy	13.9%
45	Progressive Muscular Atrophy	13.9%
46	Subacute Combined Degeneration	13.9%
47	Marchiafava-Bignami Disease	13.3%
48	Amyotrophic Lateral Sclerosis	13.2%
49	Parkinson Disease	13.2%
50	Meningoencephalitis	13.1%
51	Ophthalmoplegic Migraine	13%
52	Parasomnia	12.8%
53	Spinal Cord Injuries	12.6%
54	Brain Diseases	12.4%
55	Dysautonomia	12.4%
56	Meningitis	12.4%
57	Movement Disorders	12.4%
58	Pachymeningitis	12.4%
59	Spinal Cord Diseases	12.4%
60	Vagus Nerve Disorder	12.4%
61	Glossopharyngeal Neuralgia	12.4%
62	Abducens Nerve Diseases	12.4%
63	Heavy Metal Poisoning, Nervous System	12.4%
64	Neuromuscular Junction Diseases	12.4%
65	Tauopathies	12.4%
66	Trochlear Nerve Diseases	12.4%
67	Peripheral Nervous System Diseases	12.4%
68	Peripheral Nerve Injuries	12.2%
69	Myasthenia Gravis	12.1%
70	Asterixis	12.1%
71	Ballismus	12.1%
72	Lewy Body Disease	11.8%
73	Guillain-Barre Syndrome	11.7%
74	Dandy-Walker Syndrome	11.6%
75	Myelitis	11.6%
76	Progressive bulbar palsy	11.6%
77	Bulbar palsy	11.6%
78	Pneumocephalus	11.5%
79	Poliomyelitis	11.5%
80	Striatonigral Degeneration	11.4%
81	Causalgia	11.1%
82	Neuroleptic Malignant Syndrome	10.7%
83	Myelinolysis, Central Pontine	10.7%
84	Chronic Fatigue Syndrome	10.5%
85	Progressive supranuclear palsy	10.5%
86	Lambert-Eaton Myasthenic Syndrome	10.4%
87	Epidural Abscess	10.4%
88	Olfactory Nerve Injuries	10.4%
89	Leukoencephalitis, Acute Hemorrhagic	10.2%
90	Myelitis, Transverse	10.2%
91	MPTP Poisoning	10.2%
92	Botulism	10%
93	Central Nervous System Cysts	10%
94	Miller Fisher Syndrome	10%
95	Sleep Disorders, Intrinsic	9.9%
96	Reflex Sympathetic Dystrophy	9.8%
97	Subdural Effusion	9.8%
98	Parkinsonian Disorders	9.8%
99	Encephalomyelitis, Acute Disseminated	9.8%
100	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.8%
101	Shy-Drager Syndrome	9.8%
102	Central Nervous System Infection	9.7%
103	Myopathy	9.7%
104	Optic Neuropathy	9.7%
105	Dyskinesia, Drug-Induced	9.6%
106	Opsoclonus-Myoclonus Syndrome	9.6%
107	Neuromyelitis Optica	9.5%
108	Facial Nerve Diseases	9.4%
109	Craniocerebral Trauma	9.4%
110	Dystonia Musculorum Deformans	9.3%
111	Brain Injuries	9.3%
112	Vestibulocochlear Nerve Diseases	9.2%
113	Decerebrate State	9.2%
114	Hemiparesis	9.2%
115	Hydranencephaly	9.2%
116	Meningism	9.2%
117	Neural Tube Defects	9.2%
118	Paresis	9.2%
119	Seizures	9.2%
120	Sensation Disorders	9.2%
121	Tethered Cord Syndrome	9.2%
122	Central Nervous System Neoplasms	9.2%
123	Complex partial seizures	9.2%
124	Iniencephaly	9.2%
125	Craniorachischisis	9.2%
126	Exencephaly	9.2%
127	Monoparesis	9.2%
128	Septo-Optic Dysplasia	9.2%
129	Cortical Dysplasia	9.2%
130	Neurogenic Inflammation	9.2%
131	Gait Disorders, Neurologic	9.2%
132	Neuromuscular Manifestations	9.2%
133	Malformations of Cortical Development	9.2%
134	Brain Neoplasms	9.2%
135	Multiple Sclerosis	9.2%
136	Spinal Cord Neoplasms	9.2%
137	Sweating, Gustatory	9.2%
138	Auriculotemporal Syndrome	9.2%
139	Facial Nerve Injuries	8.9%
140	Horner Syndrome	8.8%
141	Akathisia, Drug-Induced	8.6%
142	Leukoencephalopathy, Progressive Multifocal	8.3%
143	Meige Syndrome	8.1%
144	Brachial Plexus Neuritis	8.1%
145	Neuralgic Amyotrophy	8.1%
146	Cerebral Ventriculitis	8.1%
147	Epilepsy, Post-Traumatic	8.1%
148	Scrapie	8%
149	Central Cord Syndrome	8%
150	Limbic Encephalitis	7.9%
151	Presenile dementia	7.9%
152	Senile dementia	7.9%
153	Meningitis, Bacterial	7.9%
154	Meningitis, Fungal	7.9%
155	Chorea	7.8%
156	Acrodynia	7.8%
157	Brain Abscess	7.8%
158	Ophthalmoplegia	7.8%
159	External Ophthalmoplegia	7.8%
160	Myasthenia Gravis, Autoimmune, Experimental	7.8%
161	Akinetic Mutism	7.7%
162	Anoxic Encephalopathy	7.7%
163	Arachnoiditis	7.7%
164	Basal Ganglia Diseases	7.7%
165	Brain Damage, Chronic	7.7%
166	Cerebellar Diseases	7.7%
167	Encephalitis	7.7%
168	Encephalomalacia	7.7%
169	Epilepsy	7.7%
170	Hydrocephalus	7.7%
171	Congenital Hydrocephalus	7.7%
172	Hypothalamic Diseases	7.7%
173	Aseptic Meningitis	7.7%
174	Neuritis	7.7%
175	Polyneuritis	7.7%
176	Pupil Disorders	7.7%
177	Radiculitis	7.7%
178	Syringomyelia	7.7%
179	Thalamic Diseases	7.7%
180	Intracranial Hypertension	7.7%
181	Polyneuropathy	7.7%
182	Mononeuritis	7.7%
183	Aura	7.7%
184	Leukoencephalopathy	7.7%
185	Essential Tremor	7.7%
186	Neuroaxonal Dystrophies	7.7%
187	Familial Tremor	7.7%
188	Headache Disorders	7.7%
189	Mononeuropathies	7.7%
190	Intracranial Hypotension	7.7%
191	Neurobehavioral Manifestations	7.7%
192	Brachial Plexus Neuropathies	7.7%
193	Radiculopathy	7.7%
194	Mononeuropathy Multiplex	7.7%
195	Nerve Root Compression	7.7%
196	Brain Edema	7.7%
197	Brain Hypoxia	7.7%
198	Aqueductal Stenosis	7.7%
199	Pneumorrhachis	7.7%
200	Writer's Cramp	7.7%
201	Huntington Disease	7.7%
202	Vasculitis, Central Nervous System	7.6%
203	Paraneoplastic Encephalomyelitis	7.5%
204	Charcot-Marie-Tooth Disease	7.4%
205	Uveomeningoencephalitic Syndrome	7.4%
206	Sturge-Weber Syndrome	7.3%
207	Vertigo	7.3%
208	Alcohol-Induced Disorders, Nervous System	7.3%
209	Lafora Disease	7.3%
210	Unverricht-Lundborg Syndrome	7.3%
211	Tarsal Tunnel Syndrome	7.3%
212	Cauda Equina Syndrome	7.3%
213	Posterior Leukoencephalopathy Syndrome	7.3%
214	Posterior reversible encephalopathy syndrome	7.3%
215	Lupus Vasculitis, Central Nervous System	7.2%
216	Tuberous Sclerosis	7.1%
217	Canavan Disease	7%
218	Alexander Disease	7%
219	Cerebellar Neoplasms	7%
220	Brain Death	6.9%
221	Coma, Post-Head Injury	6.9%
222	Vocal Cord Paralysis	6.7%
223	Ataxia Telangiectasia	6.7%
224	Dementia, Vascular	6.6%
225	Brain Hemorrhage, Traumatic	6.6%
226	Amblyopia	6.6%
227	Myotonia Congenita	6.6%
228	Paraneoplastic Cerebellar Degeneration	6.6%
229	Creutzfeldt-Jakob disease	6.5%
230	Basal Ganglia Cerebrovascular Disease	6.5%
231	Cerebrospinal Fluid Otorrhea	6.5%
232	Cerebrospinal Fluid Rhinorrhea	6.5%
233	Neuritis, Autoimmune, Experimental	6.5%
234	Gait Ataxia	6.5%
235	Friedreich Ataxia	6.5%
236	Brain Injuries, Diffuse	6.5%
237	Traumatic Brain Injury	6.5%
238	Cerebellar Ataxia	6.5%
239	Supratentorial Neoplasms	6.5%
240	Torticollis	6.5%
241	Multiple Sclerosis, Chronic Progressive	6.5%
242	Multiple Sclerosis, Relapsing-Remitting	6.5%
243	Myoclonic Epilepsy	6.5%
244	Epilepsy, Temporal Lobe	6.5%
245	Epilepsy, Rolandic	6.5%
246	Benign Rolandic Epilepsy	6.5%
247	Voice Disorders	6.3%
248	Voice Disturbance	6.3%
249	Smith-Magenis syndrome	6.1%
250	Dural Arteriovenous Fistula	6.1%
251	Carotid Artery Injuries	6.1%
252	Tuberculosis, Meningeal	6%
253	Brain Diseases, Metabolic	5.9%
254	Cerebrovascular Disorders	5.9%
255	Myositis	5.9%
256	Optic Atrophy	5.9%
257	Optic Neuritis	5.9%
258	Papilledema	5.9%
259	Strabismus	5.9%
260	Tolosa-Hunt Syndrome	5.9%
261	Cerebrovascular Insufficiency	5.9%
262	Isaacs syndrome	5.9%
263	Arsenic Poisoning	5.9%
264	Dementia	5.9%
265	Myotonic Disorders	5.9%
266	Central Nervous System Fungal Infections	5.9%
267	Conus Medullaris Syndrome	5.9%
268	Myasthenic Syndromes, Congenital	5.9%
269	Spinal Cord Vascular Diseases	5.9%
270	Carpal Tunnel Syndrome	5.9%
271	Vascular Headaches	5.9%
272	Myotonic Dystrophy	5.8%
273	neurofibroma	5.8%
274	Hypoxia-Ischemia, Brain	5.8%
275	Sciatica	5.8%
276	Tardive Dyskinesia	5.8%
277	Hepatolenticular Degeneration	5.8%
278	Persistent Vegetative State	5.8%
279	Diabetic Neuropathies	5.8%
280	Facial Injuries	5.8%
281	Facial Neuralgia	5.8%
282	Diabetic Amyotrophy	5.8%
283	Diabetic Autonomic Neuropathy	5.8%
284	Manganese Poisoning	5.8%
285	Orthostatic intolerance	5.8%
286	Anosmia	5.7%
287	Ataxia	5.7%
288	Athetosis	5.7%
289	Catalepsy	5.7%
290	Dystonia	5.7%
291	Hemiplegia	5.7%
292	Locked-In Syndrome	5.7%
293	Meningeal Neoplasms	5.7%
294	Meningomyelocele	5.7%
295	Muscle Hypertonia	5.7%
296	Muscle hypotonia	5.7%
297	Myoclonus	5.7%
298	Myotonia	5.7%
299	Neuralgia	5.7%
300	Paraplegia	5.7%
301	Pseudobulbar Palsy	5.7%
302	Quadriplegia	5.7%
303	Spasm	5.7%
304	Spastic Paraplegia	5.7%
305	Status Epilepticus	5.7%
306	Taste Disorders	5.7%
307	Tremor	5.7%
308	Spina Bifida	5.7%
309	Monoplegia	5.7%
310	Hypokinesia	5.7%
311	Paraparesis	5.7%
312	Bradykinesia	5.7%
313	Waxy flexibility	5.7%
314	Action Tremor	5.7%
315	Resting Tremor	5.7%
316	Dysosmia	5.7%
317	Quadriparesis	5.7%
318	Mercury Poisoning, Nervous System	5.7%
319	Olfaction Disorders	5.7%
320	Myokymia	5.7%
321	Lead Poisoning, Nervous System	5.7%
322	Vestibular Neuronitis	5.7%
323	Somatosensory Disorders	5.7%
324	Neuropathic pain	5.7%
325	Hyperkinesia	5.7%
326	Intention tremor	5.7%
327	Alcohol Withdrawal Seizures	5.7%
328	Juvenile Myoclonic Epilepsy	5.6%
329	Myoclonic Epilepsies, Progressive	5.6%
330	Akathisia	5.6%
331	Restlessness	5.6%
332	Psychomotor Agitation	5.6%
333	Leukomalacia, Periventricular	5.5%
334	Alice in Wonderland Syndrome	5.4%
335	Cerebral Palsy	5.4%
336	Epilepsies, Partial	5.4%
337	Epilepsy, Generalized	5.4%
338	Pseudotumor Cerebri	5.4%
339	Sciatic Neuropathy	5.4%
340	Hypertensive Encephalopathy	5.4%
341	Ulnar Neuropathies	5.4%
342	Lesion of Sciatic Nerve	5.4%
343	Simple Partial Seizures	5.4%
344	Epilepsy, Reflex	5.4%
345	Ulnar Neuritis	5.4%
346	Radial nerve compression	5.4%
347	Radial Tunnel Syndrome	5.4%
348	Peroneal Neuropathies	5.4%
349	Radial Neuropathy	5.4%
350	Median Neuropathy	5.4%
351	Sciatic Nerve Palsy	5.4%
352	Femoral Neuropathy	5.4%
353	Tibial Neuropathy	5.4%
354	Ulnar Nerve Palsy	5.4%
355	Postural Orthostatic Tachycardia Syndrome	5.4%
356	Radial nerve palsy	5.4%
357	Headache Disorders, Primary	5.4%
358	Headache Disorders, Secondary	5.4%
359	Medication overuse headache	5.4%
360	Brain Concussion	5.3%
361	Reflex, Abnormal	5.2%
362	Hyporeflexia	5.2%
363	Hyperreflexia	5.2%
364	Cubital Tunnel Syndrome	5.2%
365	Diffuse Axonal Injury	5.1%
366	Brain Stem Neoplasms	5.1%
367	Vertebral Artery Dissection	5.1%
368	Amnesia, Transient Global	5.1%
369	Gait Apraxia	5.1%
370	Optic Nerve Glioma	5.1%
371	Toxoplasmosis, Cerebral	5.1%
372	Refsum Disease	5%
373	Pituitary Adenoma	4.9%
374	Pituitary Neoplasms	4.9%
375	Hand-Arm Vibration Syndrome	4.9%
376	Meningitis, Cryptococcal	4.9%
377	Meningitis, Listeria	4.9%
378	Meningitis, Haemophilus	4.8%
379	Meningitis, Pneumococcal	4.8%
380	Frontotemporal dementia	4.8%
381	Vision Disorders	4.8%
382	Metamorphopsia	4.8%
383	Visual Impairment	4.8%
384	Fibromyalgia	4.8%
385	Optic Neuropathy, Ischemic	4.8%
386	Anterior Ischemic Optic Neuropathy	4.8%
387	Central Nervous System Bacterial Infections	4.8%
388	Medial Tibial Stress Syndrome	4.8%
389	Alstrom Syndrome	4.7%
390	Facial Hemiatrophy	4.7%
391	Melkersson-Rosenthal Syndrome	4.7%
392	Mitochondrial Myopathies	4.7%
393	Mitochondrial Encephalomyopathies	4.7%
394	Anisocoria	4.7%
395	Confusion	4.7%
396	Facial paralysis	4.7%
397	Lethargy	4.7%
398	Memory Disorders	4.7%
399	Muscle Cramp	4.7%
400	Perceptual Disorders	4.7%
401	Psychomotor Disorders	4.7%
402	Tonic Pupil	4.7%
403	Eosinophilia-Myalgia Syndrome	4.7%
404	Anhedonia	4.7%
405	Disorientation	4.7%
406	Facial Paresis	4.7%
407	Memory Loss	4.7%
408	Hemisensory Neglect	4.7%
409	Dysacusis	4.7%
410	Anencephaly	4.6%
411	Meningocele	4.6%
412	Muscular Atrophy	4.6%
413	Respiratory Paralysis	4.6%
414	Encephalocele	4.6%
415	Basal Ganglia Hemorrhage	4.6%
416	Tetany	4.6%
417	Choroid Plexus Papilloma	4.5%
418	Pituitary Apoplexy	4.4%
419	Amyloid Neuropathies, Familial	4.3%
420	Polyradiculopathy	4.3%
421	Post-Traumatic Headache	4.3%
422	Tension Headache	4.3%
423	Epilepsy, Complex Partial	4.3%
424	Migraine Disorders	4.3%
425	Abdominal Migraine	4.3%
426	Status Migrainosus	4.3%
427	Cervicogenic Headache	4.3%
428	Brain Contusion	4.3%
429	Pituitary Diseases	4.3%
430	Brain Infarction	4.3%
431	Subarachnoid Hemorrhage, Traumatic	4.3%
432	Carotid Artery, Internal, Dissection	4.3%
433	Subacute Sclerosing Panencephalitis	4.2%
434	Thoracic Outlet Syndrome	4.2%
435	Acoustic Neuroma	4.1%
436	Classical Lissencephalies and Subcortical Band Heterotopias	4.1%
437	Carotid Artery Diseases	4.1%
438	Brain Ischemia	4.1%
439	Esotropia	4.1%
440	Exotropia	4.1%
441	Hypotension, Orthostatic	4.1%
442	Cerebrovascular accident	4.1%
443	Polymyositis	4.1%
444	Kluver-Bucy Syndrome	4.1%
445	Vasospasm, Intracranial	4.1%
446	Spinal Cord Ischemia	4.1%
447	Intracranial Arterial Diseases	4.1%
448	Post-Exercise Hypotension	4.1%
449	Putaminal Hemorrhage	4.1%
450	Auditory Perceptual Disorders	4.1%
451	Trigeminal Nerve Disorder	4.1%
452	Dermal Sinus	4%
453	Dysgeusia	4%
454	Formication	4%
455	Hyperalgesia	4%
456	Hyperesthesia	4%
457	Hypesthesia	4%
458	Language Disorders	4%
459	Numbness	4%
460	Paresthesia	4%
461	Paraparesis, Spastic	4%
462	Spina Bifida Cystica	4%
463	Trismus	4%
464	Spina Bifida Occulta	4%
465	Epilepsia Partialis Continua	4%
466	Hypogeusia	4%
467	Meningeal Carcinomatosis	4%
468	Brown-Sequard Syndrome	4%
469	Lissencephaly	4%
470	Polymicrogyria	4%
471	Pachygyria	4%
472	Schizencephaly	4%
473	Lockjaw	4%
474	Allodynia	4%
475	Lead Poisoning, Nervous System, Childhood	4%
476	Lead Poisoning, Nervous System, Adult	4%
477	Periventricular Nodular Heterotopia	4%
478	Ageusia	4%
479	Tuberculosis, Central Nervous System	4%
480	Adrenoleukodystrophy	4%
481	Giant Cell Arteritis	4%
482	Temporal Arteritis	4%
483	Infarction, Middle Cerebral Artery	4%
484	Infarction, Anterior Cerebral Artery	4%
485	Infarction, Posterior Cerebral Artery	4%
486	Duane Retraction Syndrome	4%
487	Consciousness Disorders	3.9%
488	Mental Retardation	3.9%
489	Muscle Weakness	3.9%
490	Depressed Level of Consciousness	3.9%
491	Mental deficiency	3.9%
492	Intellectual Disability	3.9%
493	Mobius Syndrome	3.9%
494	Bell Palsy	3.9%
495	Catatonia	3.9%
496	Herpes Zoster Oticus	3.9%
497	Familial Periodic Paralysis	3.9%
498	Aphonia	3.8%
499	Dysphonia	3.8%
500	Cluster Headache	3.8%
501	Migraine with Aura	3.8%
502	Familial Hemiplegic Migraine	3.8%
503	Chronic Paroxysmal Hemicrania	3.8%
504	SUNCT Syndrome	3.8%
505	Paroxysmal Hemicrania	3.8%
506	Cerebral Infarction	3.7%
507	Brain Stem Infarctions	3.7%
508	Alexia	3.7%
509	Dyslexia	3.7%
510	MELAS Syndrome	3.5%
511	Moyamoya Disease	3.5%
512	Lateral Medullary Syndrome	3.5%
513	Neurofibrosarcoma	3.4%
514	Hematoma, Subdural	3.4%
515	Hematoma, Epidural, Cranial	3.4%
516	Eye Injuries	3.4%
517	Muscular Dystrophy	3.3%
518	Congenital nystagmus	3.3%
519	Orbital Myositis	3.3%
520	West Nile Fever	3.3%
521	Empty Sella Syndrome	3.3%
522	Hyperpituitarism	3.3%
523	Hypopituitarism	3.3%
524	Hypophysitis	3.3%
525	Diplopia	3.3%
526	Muscle Rigidity	3.3%
527	Muscle Spasticity	3.3%
528	Scotoma	3.3%
529	Photophobia	3.3%
530	Cogwheel Rigidity	3.3%
531	Hemifacial Spasm	3.3%
532	Amaurosis	3.3%
533	Blindness	3.3%
534	Nuchal Rigidity	3.3%
535	Myalgia	3.3%
536	Reye Syndrome	3.3%
537	Neuroaspergillosis	3.3%
538	Pyomyositis	3.3%
539	Intracranial Embolism and Thrombosis	3.3%
540	Hepatic Encephalopathy	3.3%
541	Agnosia	3.3%
542	Apraxias	3.3%
543	Hallucinations	3.3%
544	Hemianopsia	3.3%
545	Hyperacusis	3.3%
546	Tinnitus	3.3%
547	Visual Agnosia	3.3%
548	Anosognosia	3.3%
549	Wernicke-Korsakoff Syndrome	3.3%
550	Phonophobia	3.3%
551	Hearing Loss	3.3%
552	Neuronal Ceroid-Lipofuscinoses	3.3%
553	Optic Atrophy, Hereditary, Leber	3.3%
554	Cerebral Arterial Diseases	3.2%
555	Vertebrobasilar Insufficiency	3.2%
556	Anterior Spinal Artery Syndrome	3.2%
557	Basilar Artery Stenosis	3.2%
558	Vertebral Artery Stenosis	3.2%
559	Intracranial Hemorrhage, Hypertensive	3.2%
560	Transient Cerebral Ischemia	3.2%
561	Sarcopenia	3.2%
562	Trigeminal Neuralgia	3.2%
563	Kearns-Sayre syndrome	3.2%
564	Agraphia	3.2%
565	Anomia	3.2%
566	Cluttering	3.2%
567	Language Development Disorders	3.2%
568	Speech Disorders	3.2%
569	Syncope	3.2%
570	Stupor	3.2%
571	Dysgraphia	3.2%
572	Presyncope	3.2%
573	Dyslalia	3.2%
574	Aicardi's syndrome	2.9%
575	Hoarseness	2.9%
576	Hematoma, Subdural, Intracranial	2.9%
577	Hematoma, Subdural, Chronic	2.9%
578	Hematoma, Subdural, Acute	2.9%
579	Cockayne Syndrome	2.9%
580	Alcohol Withdrawal Delirium	2.9%
581	Pseudorabies	2.9%
582	Hyperprolactinemia	2.9%
583	Subclavian Steal Syndrome	2.8%
584	Pick Disease of the Brain	2.8%
585	Aphasia	2.8%
586	Articulation Disorders	2.8%
587	Echolalia	2.8%
588	Stuttering	2.8%
589	Dysphasia	2.8%
590	Amnesia	2.8%
591	Delirium	2.8%
592	Dissociative Amnesia	2.8%
593	Color blindness	2.8%
594	Global Amnesia	2.8%
595	Cri-du-Chat Syndrome	2.7%
596	Down Syndrome	2.7%
597	Brain Diseases, Metabolic, Inborn	2.7%
598	Trisomy 21	2.7%
599	POEMS Syndrome	2.7%
600	Meningioma	2.7%
601	Williams Syndrome	2.7%
602	Microcephaly	2.7%
603	Macrocephaly	2.7%
604	Neurosyphilis	2.7%
605	Hypokalemic periodic paralysis	2.7%
606	Porencephaly	2.7%
607	Toxoplasmosis, Congenital	2.6%
608	Eye Burns	2.6%
609	Malaria, Cerebral	2.6%
610	Carotid Stenosis	2.6%
611	Intracranial Aneurysm	2.6%
612	Welander Distal Myopathy	2.6%
613	Dysarthria	2.6%
614	Neurocysticercosis	2.6%
615	Amaurosis Fugax	2.6%
616	Blindness, Cortical	2.6%
617	Dyscalculia	2.6%
618	Intracranial Arteriosclerosis	2.6%
619	Cerebral Atherosclerosis	2.6%
620	Rett Syndrome	2.6%
621	Subarachnoid Hemorrhage	2.6%
622	Cerebral Arteriosclerosis	2.6%
623	Cerebral Hemorrhage	2.6%
624	Cerebral Thrombosis	2.6%
625	Intracranial Embolism	2.6%
626	Intracranial Thrombosis	2.6%
627	Deafness	2.6%
628	Hearing Loss, Sudden	2.6%
629	Gerstmann Syndrome	2.6%
630	Hearing Loss, Bilateral	2.6%
631	Hearing Loss, High-Frequency	2.6%
632	Hearing Loss, Mixed Conductive-Sensorineural	2.6%
633	Prosopagnosia	2.6%
634	Apraxia, Ideomotor	2.6%
635	Charles Bonnet Syndrome	2.6%
636	Hearing Loss, Unilateral	2.6%
637	Complete Hearing Loss	2.6%
638	Alien Hand Syndrome	2.6%
639	Deaf Mutism	2.6%
640	Holoprosencephaly	2.6%
641	Prader-Willi Syndrome	2.3%
642	Wernicke Encephalopathy	2.3%
643	AIDS Dementia Complex	2.3%
644	Phantom pain	2.3%
645	Phantom Limb Pain	2.3%
646	Lyme Neuroborreliosis	2.3%
647	Mutism	2.3%
648	Selective Mutism	2.3%
649	Acromegaly	2.3%
650	Cerebral Amyloid Angiopathy	2.3%
651	Sinus Thrombosis, Intracranial	2.2%
652	Dermatomyositis	2.2%
653	Corneal Scar	2.2%
654	Waterhouse-Friderichsen Syndrome	2.2%
655	Muscular Dystrophy, Duchenne	2.2%
656	Retrograde amnesia	2.2%
657	Amnesia, Anterograde	2.2%
658	Menkes Kinky Hair Syndrome	2.2%
659	Carotid Artery Thrombosis	2.2%
660	Alexia, Pure	2.1%
661	Kernicterus	2.1%
662	Cavernous Sinus Thrombosis	2.1%
663	Sagittal Sinus Thrombosis	2.1%
664	Corneal Perforation	1.9%
665	Fragile X Syndrome	1.8%
666	Rubinstein-Taybi Syndrome	1.8%
667	Nelson Syndrome	1.7%
668	Fabry Disease	1.7%
669	Prolactinoma	1.6%
670	Growth Hormone-Secreting Pituitary Adenoma	1.6%
671	Galactosemias	1.6%
672	Urea Cycle Disorders, Inborn	1.6%
673	Tyrosinemias	1.6%
674	Homocystinuria	1.4%
675	Leigh Disease	1.4%
676	Mucopolysaccharidosis II	1.3%
677	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.2%
678	Glycogen storage disease type II	1.1%
679	Zellweger Syndrome	1.1%
680	Gaucher Disease	0.9%
681	Tay-Sachs Disease	0.9%
682	Niemann-Pick Disease, Type C	0.8%

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