MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lown-Ganong-Levine Syndrome

(UMLS:C0024054)

Definition:: A form of ventricular pre-excitation characterized by a short PR interval and a normal QRS complex. In this syndrome, the atrial impulse conducts via the JAMES FIBERS which connect the atrium to BUNDLE OF HIS bypassing the upper ATRIOVENTRICULAR NODE. HEART VENTRICLES are depolarized normally through the His-Purkinje system.
UMLS ID:: C0024054
MeSH ID:: D008151

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.067.780.560|C14.280.123.750.560

Synonym(s)

Lown-Ganong-Levine Syndrome

Lown Ganong Levine Syndrome

Lown Ganong Levine syndrome

Lown-Ganong-Levine

Lown-Ganong-Levine syndrome

Syndrome of short P-R interval, normal QRS complexes AND supraventricular tachycardias

Syndrome of short P-R interval, normal QRS complexes and supraventricular tachycardias

lgl

lown ganong levine syndrome

10.

lown ganong levine syndrome (LGL)

11.

lown-ganong-lavine

12.

lown-ganong-levine syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Alendronate	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Wolff-Parkinson-White Syndrome	46.5%
2	Heart Block	39.5%
3	Tachycardia	39.5%
4	Tachyarrhythmia	39.5%
5	Myocardial Ischemia	33.9%
6	Cardiac Tamponade	33.3%
7	Endocarditis	33.3%
8	Cardiac Arrest	33.3%
9	Heart failure	33.3%
10	Pericardial effusion	33.3%
11	Pericarditis	33.3%
12	Pneumopericardium	33.3%
13	Cor pulmonale	33.3%
14	Ventricular Outflow Obstruction	33.3%
15	Ventricular Dysfunction	33.3%
16	Cardiomyopathies	33.3%
17	Pleuropericarditis	33.3%
18	Long QT Syndrome	32.8%
19	Aortic Valve Stenosis	29.5%
20	Cardiomyopathy, Dilated	29.5%
21	Pulmonary Valve Stenosis	29.5%
22	Sick Sinus Syndrome	27.6%
23	Adams-Stokes Syndrome	25.8%
24	Atrioventricular Block	25.8%
25	Bundle-Branch Block	25.8%
26	Atrial Premature Complexes	25.8%
27	Sinoatrial Block	25.8%
28	Tachycardia, Paroxysmal	25.8%
29	Supraventricular tachycardia	25.8%
30	Tachycardia, Ventricular	25.8%
31	Tachycardia, Reciprocating	25.8%
32	Cardiac Output, High	25.4%
33	Myocardial Stunning	25.4%
34	Low Cardiac Output Syndrome	25.4%
35	Cardiomegaly	25%
36	Postpericardiotomy Syndrome	25%
37	Cardiac Hypertrophy	25%
38	Rheumatic Heart Disease	24.7%
39	Sinus Arrhythmia	24.6%
40	Atrial Fibrillation	24.6%
41	Atrial Flutter	24.6%
42	Ventricular Fibrillation	24.6%
43	Ventricular Flutter	24.6%
44	Parasystole	24.6%
45	Paroxysmal atrial fibrillation	24.6%
46	Bradycardia	24.6%
47	Tricuspid Atresia	23%
48	Arrhythmogenic Right Ventricular Dysplasia	23%
49	Myocardial Reperfusion Injury	22.5%
50	Hypertrophic Cardiomyopathy	21.9%
51	Hypertrophic obstructive cardiomyopathy	21.9%
52	Romano-Ward Syndrome	21.4%
53	Vascular Diseases	20.9%
54	Coronary heart disease	19.7%
55	Myocardial Infarction	19.7%
56	Acute Coronary Syndrome	19.7%
57	Aortic Valve Insufficiency	19.6%
58	Restrictive cardiomyopathy	19.6%
59	Endocardial Fibroelastosis	19.6%
60	Heart Rupture, Post-Infarction	19.6%
61	Mitral Valve Insufficiency	19.6%
62	Mitral Valve Stenosis	19.6%
63	Myocarditis	19.6%
64	Pericarditis, Constrictive	19.6%
65	Pulmonary Valve Insufficiency	19.6%
66	Tricuspid Valve Insufficiency	19.6%
67	Tricuspid Valve Stenosis	19.6%
68	Ventricular Dysfunction, Left	19.6%
69	Right Ventricular Dysfunction	19.6%
70	Endomyocardial Fibrosis	19.6%
71	Carditis	19.6%
72	Heart Failure, Systolic	19.6%
73	Heart Failure, Diastolic	19.6%
74	Supravalvular aortic stenosis	19.4%
75	Tachycardia, Atrioventricular Nodal Reentry	19.2%
76	Tachycardia, Ectopic Atrial	19.2%
77	Tachycardia, Ectopic Junctional	19.2%
78	Sinus Tachycardia	19.2%
79	Torsades de Pointes	19.2%
80	Accelerated Idioventricular Rhythm	19.2%
81	Carcinoid Heart Disease	16.2%
82	Sinus Arrest, Cardiac	16.1%
83	Kounis Syndrome	16%
84	Pregnancy Complications, Cardiovascular	15.8%
85	Cardiovascular Abnormalities	15.8%
86	Bacterial Endocarditis	15.7%
87	Aortic coarctation	15.7%
88	Cor Triatriatum	15.7%
89	Coronary Vessel Anomalies	15.7%
90	Patent ductus arteriosus	15.7%
91	Ebstein Anomaly	15.7%
92	Heart Septal Defects	15.7%
93	Tetralogy of Fallot	15.7%
94	Transposition of Great Vessels	15.7%
95	Hypoplastic Left Heart Syndrome	15.7%
96	Angina Pectoris	15.6%
97	Edema, Cardiac	14.8%
98	Diabetic Cardiomyopathies	14.8%
99	Cardiomyopathy, Alcoholic	14.6%
100	Sudden Cardiac Death	14.6%
101	Left Ventricular Hypertrophy	14.6%
102	Right Ventricular Hypertrophy	14.6%
103	Chagas Cardiomyopathy	14.6%
104	Coronary Aneurysm	14.3%
105	Dextrocardia	13.1%
106	Aortic Valve Prolapse	12.9%
107	Coronary Thrombosis	12.9%
108	Tricuspid Valve Prolapse	12.9%
109	Coronary Occlusion	12.9%
110	Microvascular Angina	12.9%
111	Coronary Stenosis	12.9%
112	ST segment elevation myocardial infarction	12.9%
113	Takotsubo Cardiomyopathy	12.9%
114	Coronary Artery Disease	12.9%
115	Dyspnea, Paroxysmal	11.8%
116	Aneurysm	11.1%
117	Angiomatosis	11.1%
118	Aortic Diseases	11.1%
119	Arterial Occlusive Diseases	11.1%
120	Hyperemia	11.1%
121	Hypotension	11.1%
122	Superior Vena Cava Syndrome	11.1%
123	Telangiectasis	11.1%
124	Vasculitis	11.1%
125	Venous Insufficiency	11.1%
126	Peripheral Vascular Diseases	11.1%
127	Embolism and Thrombosis	11.1%
128	Angiodysplasia	11.1%
129	Capillary Leak Syndrome	11.1%
130	Prehypertension	11.1%
131	Shock, Cardiogenic	10.4%
132	Aortopulmonary Septal Defect	10.3%
133	Double Outlet Right Ventricle	10.3%
134	Endocardial Cushion Defects	10.3%
135	Myocardial bridging	10.3%
136	Aorticopulmonary Septal Defect	10.3%
137	Angina, Unstable	10.3%
138	Noonan Syndrome	9.9%
139	Aortic Aneurysm	9.8%
140	Aortitis	9.8%
141	Leriche Syndrome	9.8%
142	Periphlebitis	9.8%
143	Phlebitis	9.8%
144	Thromboangiitis Obliterans	9.8%
145	Lown-Ganong-Levine Syndrome	9.7%
146	Coronary Restenosis	9.6%
147	Embolism, Amniotic Fluid	9.3%
148	Marfan Syndrome	8.9%
149	Vascular System Injuries	8.8%
150	Retinal Vein Occlusion	8.7%
151	Compartment syndromes	8.5%
152	Hepatic Veno-Occlusive Disease	8.5%
153	Peliosis Hepatis	8.5%
154	Varicocele	8.5%
155	Subacute Bacterial Endocarditis	8.4%
156	Cerebrovascular Disorders	8.3%
157	Diabetic Angiopathies	8.3%
158	Reperfusion Injury	8.3%
159	Splenic Infarction	8.3%
160	Cerebrovascular Insufficiency	8.3%
161	Vascular Neoplasms	8.3%
162	Spinal Cord Vascular Diseases	8.3%
163	Vasoplegia	8.3%
164	Hemorrhoids	8.3%
165	Thoracic Outlet Syndrome	8.3%
166	Postphlebitic Syndrome	8.1%
167	Arteriovenous fistula	8.1%
168	Malignant Atrophic Papulosis	7.9%
169	Shwartzman Phenomenon	7.8%
170	May-Thurner Syndrome	7.8%
171	Truncus Arteriosus, Persistent	7.7%
172	Angina Pectoris, Variant	7.6%
173	Thrombophlebitis	7.1%
174	Hand-Arm Vibration Syndrome	6.9%
175	Blue Toe Syndrome	6.9%
176	Optic Neuropathy, Ischemic	6.8%
177	Anterior Ischemic Optic Neuropathy	6.8%
178	Mesenteric vascular insufficiency	6.8%
179	Scimitar Syndrome	6.8%
180	Angioedema	6.6%
181	Aortic Rupture	6.6%
182	Colitis, Ischemic	6.6%
183	Aneurysm, Dissecting	6.5%
184	Arteriosclerosis	6.5%
185	Arteritis	6.5%
186	Embolism	6.5%
187	Erythromelalgia	6.5%
188	Fibromuscular Dysplasia	6.5%
189	Malignant Hypertension	6.5%
190	Raynaud Disease	6.5%
191	Thromboembolism	6.5%
192	Thrombosis	6.5%
193	Essential Hypertension	6.5%
194	Aneurysm, Ruptured	6.5%
195	Iliac Aneurysm	6.5%
196	Pulmonary artery stenosis	6.5%
197	White Coat Hypertension	6.5%
198	Systemic Vasculitis	6.5%
199	Embolus	6.5%
200	Intracranial Embolism and Thrombosis	6.5%
201	Carotid Stenosis	6.5%
202	Intracranial Aneurysm	6.5%
203	Aortic Aneurysm, Abdominal	6.5%
204	Aortic Aneurysm, Thoracic	6.5%
205	Moyamoya Disease	6%
206	Carotid Artery Thrombosis	5.9%
207	Vasculitis, Central Nervous System	5.7%
208	Polyarteritis Nodosa	5.2%
209	Takayasu Arteritis	5.2%
210	Turner Syndrome	5.2%
211	Intracranial Arteriosclerosis	5.1%
212	Cerebral Atherosclerosis	5.1%
213	Cerebral Arteriosclerosis	5.1%
214	Retinal Artery Occlusion	5%
215	Retinal Vasculitis	5%
216	Hypertensive Retinopathy	5%
217	Anterior Compartment Syndrome	4.9%
218	Vasculitis, Leukocytoclastic, Cutaneous	4.9%
219	Gastric Antral Vascular Ectasia	4.9%
220	Abdominal Compartment Syndrome	4.9%
221	Carotid Artery Diseases	4.9%
222	Brain Ischemia	4.9%
223	Ectopia Cordis	4.9%
224	Hypotension, Orthostatic	4.9%
225	Cerebrovascular accident	4.9%
226	Varicose Ulcer	4.9%
227	Williams Syndrome	4.9%
228	Vasospasm, Intracranial	4.9%
229	Spinal Cord Ischemia	4.9%
230	Intracranial Arterial Diseases	4.9%
231	Primary Graft Dysfunction	4.9%
232	Single umbilical artery	4.9%
233	Post-Exercise Hypotension	4.9%
234	Kearns-Sayre syndrome	4.8%
235	Cerebral Thrombosis	4.5%
236	Intracranial Embolism	4.5%
237	Intracranial Thrombosis	4.5%
238	Giant Cell Arteritis	4.3%
239	Temporal Arteritis	4.3%
240	Arteriosclerosis Obliterans	4.3%
241	Atherosclerosis	4.3%
242	Air Embolism	4.3%
243	Endarteritis	4.3%
244	Venous Thrombosis	4.3%
245	Deep Vein Thrombosis	4.3%
246	Venous Thromboembolism	4.3%
247	Brain Infarction	4.3%
248	CREST Syndrome	4%
249	Mesenteric Vascular Occlusion	4%
250	Mucocutaneous Lymph Node Syndrome	4%
251	Diabetic Retinopathy	4%
252	Sturge-Weber Syndrome	4%
253	Livedo Reticularis	3.9%
254	Renal hypertension	3.9%
255	Renal Artery Obstruction	3.9%
256	Renal Artery Stenosis	3.9%
257	Hemangioma, Cavernous	3.9%
258	Basal Ganglia Cerebrovascular Disease	3.9%
259	Vascular Headaches	3.9%
260	Scurvy	3.9%
261	Kartagener Syndrome	3.8%
262	Vertebral Artery Dissection	3.7%
263	Subarachnoid Hemorrhage, Traumatic	3.6%
264	Carotid Artery, Internal, Dissection	3.6%
265	Sinus Thrombosis, Intracranial	3.5%
266	Lemierre Syndrome	3.5%
267	Dural Arteriovenous Fistula	3.3%
268	Intermittent Claudication	3.3%
269	Pulmonary Embolism	3.3%
270	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.3%
271	Ischemic contracture	3.3%
272	Angioedemas, Hereditary	3.3%
273	Cryoglobulinemia	3.3%
274	Leukomalacia, Periventricular	3.3%
275	No-Reflow Phenomenon	3.3%
276	Carotid Artery Injuries	3.2%
277	Diabetic Foot	3.2%
278	Cerebral Arterial Diseases	3.2%
279	Vertebrobasilar Insufficiency	3.2%
280	Anterior Spinal Artery Syndrome	3.2%
281	Basilar Artery Stenosis	3.2%
282	Vertebral Artery Stenosis	3.2%
283	Intracranial Hemorrhage, Hypertensive	3.2%
284	Transient Cerebral Ischemia	3.2%
285	Cerebral Infarction	3.2%
286	Brain Stem Infarctions	3.2%
287	Infarction, Middle Cerebral Artery	3.2%
288	Infarction, Anterior Cerebral Artery	3.2%
289	Infarction, Posterior Cerebral Artery	3.2%
290	Cavernous Sinus Thrombosis	3%
291	Sagittal Sinus Thrombosis	3%
292	Basal Ganglia Hemorrhage	2.8%
293	Shy-Drager Syndrome	2.8%
294	Purpura, Hyperglobulinemic	2.8%
295	Lateral Medullary Syndrome	2.6%
296	Hypertension, Renovascular	2.6%
297	Subarachnoid Hemorrhage	2.6%
298	Hypoxia-Ischemia, Brain	2.6%
299	Cerebral Hemorrhage	2.6%
300	Hereditary Angioedema Type III	2.6%
301	Hereditary Angioedema Types I and II	2.6%
302	Behcet Syndrome	2.5%
303	Hepatic Vein Thrombosis	2.5%
304	Budd-Chiari Syndrome	2.5%
305	Waldenstrom Macroglobulinemia	2.5%
306	Multiple Myeloma	2.5%
307	Pulmonary Infarction	2.4%
308	Subclavian Steal Syndrome	2.4%
309	Ataxia Telangiectasia	2.2%
310	Pseudoxanthoma Elasticum	2.2%
311	Putaminal Hemorrhage	2.2%
312	Pituitary Apoplexy	2.2%
313	Dementia, Vascular	2.1%
314	Lupus Vasculitis, Central Nervous System	2%
315	Granulomatosis with polyangiitis	2%
316	Cerebral Amyloid Angiopathy	1.9%
317	Rheumatoid Vasculitis	1.9%
318	Hematoma, Subdural	1.2%
319	Hematoma, Epidural, Cranial	1.2%
320	MELAS Syndrome	1.2%
321	Brain Hemorrhage, Traumatic	1.1%
322	Hematoma, Subdural, Intracranial	1%
323	Hematoma, Subdural, Chronic	1%
324	Hematoma, Subdural, Acute	1%
325	Fabry Disease	0.9%

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