MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypopituitarism

(UMLS:C0020635)

Definition:: Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
UMLS ID:: C0020635
MeSH ID:: D007018

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.617.738.300

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.700.482

Synonym(s)

Hypopituitarism

Deficient secretion of one OR more pituitary hormones

Deficient secretion of one or more pituitary hormones

HYPOPITUITARISM

HYPOPITUTITARISM

Hypopituitarism, NOS

PITUITARY INSUFFICIENCY

Pituitary Insufficiency

Pituitary deficiency

10.

Pituitary failure

11.

Pituitary hypofunction

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Finasteride	FAERS: 8		US FAERS
2	Sertraline	FAERS: 6		US FAERS
3	Epoprostenol	FAERS: 5		US FAERS
4	Octreotide	FAERS: 5		US FAERS
5	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 4		US FAERS
6	Thyroxine	FAERS: 4	48615 15764279	CTD US FAERS
7	Dexamethasone	FAERS: 3	10463118	CTD US FAERS
8	Epoprostenol	FAERS: 3		OFFSIDES US FAERS
9	Hydrocortisone	FAERS: 3	15764279	CTD OFFSIDES US FAERS
10	Morphine	FAERS: 3	14631063	CTD US FAERS
11	Zonisamide	FAERS: 3		US FAERS
12	4-hydroxybutyric acid	FAERS: 2		US FAERS
13	Bleomycin	FAERS: 2		OFFSIDES US FAERS
14	Bleomycin	FAERS: 2		US FAERS
15	Cabozantinib S-malate	FAERS: 2		US FAERS
16	Diovan Hct	FAERS: 2		US FAERS
17	Ketoconazole	FAERS: 2		OFFSIDES US FAERS
18	Leuprolide	FAERS: 2		US FAERS
19	Quetiapine Fumarate	FAERS: 2		US FAERS
20	Thalidomide	FAERS: 2		US FAERS
21	Thyroxine	FAERS: 2		US FAERS
22	rofecoxib	FAERS: 2		US FAERS
23	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 1		US FAERS
24	Alprazolam	FAERS: 1		US FAERS
25	Azacitidine	FAERS: 1		US FAERS
26	Beclomethasone	FAERS: 1		US FAERS
27	Celecoxib	FAERS: 1		US FAERS
28	Cladribine	FAERS: 1		US FAERS
29	Clozapine	FAERS: 1		US FAERS
30	Cyproheptadine	FAERS: 1		US FAERS
31	Deamino Arginine Vasopressin	FAERS: 1		OFFSIDES US FAERS
32	Dipyridamole	FAERS: 1		US FAERS
33	Enalapril	FAERS: 1		US FAERS
34	Felbamate	FAERS: 1		US FAERS
35	Fluticasone	FAERS: 1		US FAERS
36	Goserelin	FAERS: 1		US FAERS
37	Hydrocodone	FAERS: 1		US FAERS
38	Imatinib Mesylate	FAERS: 1		US FAERS
39	Leuprolide	FAERS: 1		US FAERS
40	Methotrexate	FAERS: 1		US FAERS
41	Mirtazapine	FAERS: 1		US FAERS
42	Modafinil	FAERS: 1		US FAERS
43	Morphine sulphate	FAERS: 1		US FAERS
44	Nadolol	FAERS: 1		US FAERS
45	NuvaRing	FAERS: 1		US FAERS
46	Olanzapine	FAERS: 1		US FAERS
47	Paliperidone Palmitate	FAERS: 1		US FAERS
48	Prednisolone	FAERS: 1		US FAERS
49	Quetiapine Fumarate	FAERS: 1		US FAERS
50	Testosterone	FAERS: 1	15764279 17426086	CTD US FAERS
51	Triazolam	FAERS: 1		US FAERS
52	Valproic Acid	FAERS: 1		US FAERS
53	Vigabatrin	FAERS: 1		US FAERS
54	acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide	FAERS: 1		US FAERS
55	drospirenone and ethinyl estradiol combination	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
56	lanreotide	FAERS: 1		US FAERS
57	montelukast	FAERS: 1		US FAERS
58	pasireotide	FAERS: 1		SIDER US FAERS
59	reviparin	FAERS: 1	9365341	CTD US FAERS
60	Amphetamine			OFFSIDES
61	Bosentan			OFFSIDES
62	Bromocriptine	Canada Vigilance: 1	8191163 15377706	CTD Canada Vigilance
63	Cabergoline			OFFSIDES
64	Calcitriol			OFFSIDES
65	Carbamazepine			OFFSIDES
66	Cocaine		16033719 19114541	CTD
67	Cortisone		48615	CTD
68	Cyclosporine			OFFSIDES
69	Desipramine			OFFSIDES
70	Dothiepin			OFFSIDES
71	Estriol		2673747 12970278	CTD
72	Fludrocortisone			OFFSIDES
73	Gliclazide			SIDER
74	Glyburide			SIDER
75	Lamotrigine			OFFSIDES
76	Medigoxin			OFFSIDES
77	Medroxyprogesterone			SIDER
78	Mesterolone		15764279	CTD
79	Methylprednisolone			SIDER
80	Methyltestosterone		48615	CTD
81	Octreotide			OFFSIDES
82	Penicillin G			OFFSIDES
83	Prazosin			OFFSIDES
84	Progesterone		2673747	CTD
85	Quinidine			OFFSIDES
86	Ribavirin			OFFSIDES
87	Sildenafil Citrate			OFFSIDES
88	Thiotepa			SIDER
89	alosetron			SIDER
90	hexarelin		7673411	CTD
91	lafutidine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Empty Sella Syndrome	46.2%
2	Hyperpituitarism	46.2%
3	Hypophysitis	46.2%
4	Pituitary Apoplexy	34.2%
5	Hyperprolactinemia	34%
6	Pituitary Adenoma	27.6%
7	Pituitary Neoplasms	27.6%
8	Acromegaly	27.3%
9	Prolactinoma	22.2%
10	Growth Hormone-Secreting Pituitary Adenoma	22.2%
11	Nelson Syndrome	21.3%
12	Akinetic Mutism	19.6%
13	Anoxic Encephalopathy	19.6%
14	Basal Ganglia Diseases	19.6%
15	Brain Damage, Chronic	19.6%
16	Cerebellar Diseases	19.6%
17	Encephalitis	19.6%
18	Encephalomalacia	19.6%
19	Epilepsy	19.6%
20	Hydrocephalus	19.6%
21	Congenital Hydrocephalus	19.6%
22	Thalamic Diseases	19.6%
23	Intracranial Hypertension	19.6%
24	Aura	19.6%
25	Leukoencephalopathy	19.6%
26	Neuroaxonal Dystrophies	19.6%
27	Headache Disorders	19.6%
28	Intracranial Hypotension	19.6%
29	Brain Edema	19.6%
30	Brain Hypoxia	19.6%
31	Aqueductal Stenosis	19.6%
32	Subdural Effusion	18.3%
33	Encephalomyelitis	17.9%
34	Meningoencephalitis	16.5%
35	Diabetes Insipidus	16.2%
36	Meningitis	15.4%
37	Movement Disorders	15.4%
38	Pachymeningitis	15.4%
39	Spinal Cord Diseases	15.4%
40	Parkinsonian Disorders	14.9%
41	Brain Diseases, Metabolic	14.9%
42	Cerebrovascular Disorders	14.9%
43	Cerebrovascular Insufficiency	14.9%
44	Dementia	14.9%
45	Adrenal Gland Diseases	14.4%
46	Gonadal Disorders	14.4%
47	Parathyroid Diseases	14.4%
48	Thyroid Diseases	14.4%
49	Posterior Leukoencephalopathy Syndrome	14.3%
50	Posterior reversible encephalopathy syndrome	14.3%
51	Dandy-Walker Syndrome	14.2%
52	Pneumocephalus	14.1%
53	Brain Abscess	14%
54	Multiple System Atrophy	14%
55	Basal Ganglia Cerebrovascular Disease	13.9%
56	Brain Injuries	13.4%
57	Brain Neoplasms	13.3%
58	Dementia, Vascular	13.3%
59	Ocular Motility Disorders	12.9%
60	Cyclophoria	12.9%
61	Marchiafava-Bignami Disease	12.7%
62	Lewy Body Disease	12.6%
63	Myelitis	12.6%
64	Meige Syndrome	12.3%
65	Cerebral Ventriculitis	12.3%
66	Epilepsy, Post-Traumatic	12.3%
67	Central Nervous System Infection	12.1%
68	Brain Death	12.1%
69	Gigantism	12%
70	Cerebral Palsy	11.6%
71	Epilepsies, Partial	11.6%
72	Epilepsy, Generalized	11.6%
73	Pseudotumor Cerebri	11.6%
74	Hypertensive Encephalopathy	11.6%
75	Simple Partial Seizures	11.6%
76	Epilepsy, Reflex	11.6%
77	Headache Disorders, Primary	11.6%
78	Headache Disorders, Secondary	11.6%
79	Medication overuse headache	11.6%
80	Leukomalacia, Periventricular	11.6%
81	Vascular Headaches	11.5%
82	Hypoxia-Ischemia, Brain	11.4%
83	Myoclonic Epilepsy	11.4%
84	Epilepsy, Temporal Lobe	11.4%
85	Epilepsy, Rolandic	11.4%
86	Benign Rolandic Epilepsy	11.4%
87	Adrenal Gland Neoplasms	11%
88	Bone Diseases, Endocrine	10.8%
89	Endocrine Gland Neoplasms	10.8%
90	Epidural Abscess	10.7%
91	Parkinson Disease	10.7%
92	Diabetes Mellitus	10.6%
93	Amblyopia	10.6%
94	Prion Diseases	10.2%
95	Cranial nerve diseases	10.2%
96	Demyelinating Diseases	10.2%
97	Demyelination	10.2%
98	Neuromuscular Diseases	10.2%
99	Chronobiology Disorders	10.2%
100	Neuroleptic Malignant Syndrome	10.1%
101	Myelinolysis, Central Pontine	10.1%
102	Cerebellar Neoplasms	10%
103	Creutzfeldt-Jakob disease	9.9%
104	Huntington Disease	9.7%
105	Dystonia Musculorum Deformans	9.6%
106	Stiff-Person Syndrome	9.4%
107	Adrenal Cortex Diseases	9.1%
108	Euthyroid Sick Syndromes	9.1%
109	Goiter	9.1%
110	Hyperparathyroidism	9.1%
111	Hyperthyroidism	9.1%
112	Hyperthyroxinemia	9.1%
113	Hypogonadism	9.1%
114	Hypoparathyroidism	9.1%
115	Hypothyroidism	9.1%
116	Delayed Puberty	9.1%
117	Precocious Puberty	9.1%
118	Thyroiditis	9.1%
119	Hypogonadotropic hypogonadism	9.1%
120	Testotoxicosis	9.1%
121	Secondary hypothyroidism	9.1%
122	Primary Hyperthyroidism	9.1%
123	Primary Hypothyroidism	9.1%
124	Parathyroid Neoplasms	9.1%
125	Thyroid Neoplasm	9.1%
126	Thyroid carcinoma	9.1%
127	Carotid Artery Diseases	8.7%
128	Brain Ischemia	8.7%
129	Cerebrovascular accident	8.7%
130	Kluver-Bucy Syndrome	8.7%
131	Vasospasm, Intracranial	8.7%
132	Intracranial Arterial Diseases	8.7%
133	Amnesia, Transient Global	8.7%
134	Presenile dementia	8.6%
135	Senile dementia	8.6%
136	Progressive supranuclear palsy	8.6%
137	Juvenile Myoclonic Epilepsy	8.5%
138	Myoclonic Epilepsies, Progressive	8.5%
139	Dwarfism	8.5%
140	Spinal Cord Injuries	8.5%
141	Striatonigral Degeneration	8.5%
142	Arachnoiditis	8.4%
143	Aseptic Meningitis	8.4%
144	Syringomyelia	8.4%
145	Essential Tremor	8.4%
146	Familial Tremor	8.4%
147	Pneumorrhachis	8.4%
148	Writer's Cramp	8.4%
149	Spinal Muscular Atrophy	8.4%
150	Progressive Muscular Atrophy	8.4%
151	Limbic Encephalitis	8.2%
152	Asterixis	8.1%
153	Ballismus	8.1%
154	Meningitis, Bacterial	8%
155	Meningitis, Fungal	8%
156	Leukoencephalopathy, Progressive Multifocal	8%
157	Subacute Combined Degeneration	8%
158	Trauma, Nervous System	7.9%
159	Brain Injuries, Diffuse	7.9%
160	Traumatic Brain Injury	7.9%
161	Cerebellar Ataxia	7.8%
162	Supratentorial Neoplasms	7.8%
163	Motor Neuron Disease	7.8%
164	Basal Ganglia Hemorrhage	7.8%
165	Post-Traumatic Headache	7.7%
166	Tension Headache	7.7%
167	Epilepsy, Complex Partial	7.7%
168	Migraine Disorders	7.7%
169	Abdominal Migraine	7.7%
170	Status Migrainosus	7.7%
171	Cervicogenic Headache	7.7%
172	Nervous System Neoplasms	7.6%
173	Neurologic Manifestations	7.6%
174	Neurotoxicity Syndromes	7.6%
175	Brain Infarction	7.6%
176	Persistent Vegetative State	7.5%
177	Poliomyelitis	7.5%
178	Shy-Drager Syndrome	7.3%
179	Vasculitis, Central Nervous System	7.2%
180	Paraneoplastic Cerebellar Degeneration	7.2%
181	Lupus Vasculitis, Central Nervous System	7.1%
182	Amyotrophic Lateral Sclerosis	7.1%
183	Diabetic Neuropathies	7.1%
184	Diabetic Amyotrophy	7.1%
185	Diabetic Autonomic Neuropathy	7.1%
186	Chronic Fatigue Syndrome	7.1%
187	MPTP Poisoning	7.1%
188	Reye Syndrome	7%
189	Hepatolenticular Degeneration	7%
190	Adrenocortical carcinoma	7%
191	Intracranial Embolism and Thrombosis	6.9%
192	Hepatic Encephalopathy	6.9%
193	Testicular Diseases	6.9%
194	Graves Disease	6.8%
195	Ovarian Diseases	6.8%
196	Brain Hemorrhage, Traumatic	6.8%
197	Carotid Artery Injuries	6.7%
198	Congenital Hypothyroidism	6.7%
199	Cushing Syndrome	6.7%
200	Hyperaldosteronism	6.7%
201	Hyperparathyroidism, Secondary	6.7%
202	Hypoaldosteronism	6.7%
203	Thyrotoxicosis	6.7%
204	Hyperparathyroidism, Primary	6.7%
205	Thyroid Hormone Resistance Syndrome	6.7%
206	ovarian neoplasm	6.7%
207	Spinal Cord Neoplasms	6.6%
208	Thyroid Nodule	6.6%
209	Encephalomyelitis, Acute Disseminated	6.6%
210	Leukoencephalitis, Acute Hemorrhagic	6.6%
211	Toxoplasmosis, Cerebral	6.5%
212	Central Nervous System Fungal Infections	6.4%
213	Conus Medullaris Syndrome	6.4%
214	Spinal Cord Vascular Diseases	6.4%
215	Ophthalmoplegic Migraine	6.4%
216	Sleep Wake Disorders	6.2%
217	Lafora Disease	6.1%
218	Unverricht-Lundborg Syndrome	6.1%
219	Restless Legs Syndrome	6.1%
220	Friedreich Ataxia	6.1%
221	Miller Fisher Syndrome	6%
222	Autonomic Dysreflexia	6%
223	Complex Regional Pain Syndromes	6%
224	Putaminal Hemorrhage	6%
225	Polyradiculoneuropathy	5.9%
226	Polyradiculoneuritis	5.9%
227	Testicular Neoplasms	5.9%
228	Brain Diseases, Metabolic, Inborn	5.8%
229	Akathisia, Drug-Induced	5.8%
230	Cluster Headache	5.8%
231	Migraine with Aura	5.8%
232	Familial Hemiplegic Migraine	5.8%
233	Chronic Paroxysmal Hemicrania	5.8%
234	SUNCT Syndrome	5.8%
235	Paroxysmal Hemicrania	5.8%
236	Cerebral Arterial Diseases	5.7%
237	Vertebrobasilar Insufficiency	5.7%
238	Basilar Artery Stenosis	5.7%
239	Vertebral Artery Stenosis	5.7%
240	Intracranial Hemorrhage, Hypertensive	5.7%
241	Transient Cerebral Ischemia	5.7%
242	Moyamoya Disease	5.7%
243	Mitochondrial Encephalomyopathies	5.6%
244	Cerebral Infarction	5.6%
245	Brain Stem Infarctions	5.6%
246	Canavan Disease	5.6%
247	Alexander Disease	5.6%
248	Infarction, Middle Cerebral Artery	5.6%
249	Infarction, Anterior Cerebral Artery	5.6%
250	Infarction, Posterior Cerebral Artery	5.6%
251	Hyperglycemic Hyperosmolar Nonketotic Coma	5.5%
252	Hashimoto Disease	5.5%
253	Diabetic Foot	5.5%
254	Gestational Diabetes	5.5%
255	Latent Autoimmune Diabetes in Adults	5.5%
256	Myelitis, Transverse	5.4%
257	Diabetes Mellitus, Experimental	5.4%
258	Opsoclonus-Myoclonus Syndrome	5.2%
259	Diffuse Axonal Injury	5.2%
260	Brain Stem Neoplasms	5.2%
261	Adrenoleukodystrophy	5.2%
262	Central Nervous System Bacterial Infections	5.2%
263	Dysautonomia	5.1%
264	Vagus Nerve Disorder	5.1%
265	Glossopharyngeal Neuralgia	5.1%
266	Abducens Nerve Diseases	5.1%
267	Heavy Metal Poisoning, Nervous System	5.1%
268	Neuromuscular Junction Diseases	5.1%
269	Tauopathies	5.1%
270	Trochlear Nerve Diseases	5.1%
271	Peripheral Nervous System Diseases	5.1%
272	Addison Disease	5.1%
273	Diabetic Angiopathies	5.1%
274	Autoimmune thyroiditis	5.1%
275	Primary Adrenal Insufficiency	5.1%
276	Myxedema	5%
277	Orchitis	5%
278	Diabetic Cardiomyopathies	5%
279	Ovarian Hyperstimulation Syndrome	5%
280	Wernicke Encephalopathy	4.9%
281	AIDS Dementia Complex	4.9%
282	Auditory Perceptual Disorders	4.9%
283	Tuberculosis, Meningeal	4.9%
284	Dyskinesia, Drug-Induced	4.8%
285	Peripheral Nerve Injuries	4.8%
286	Myasthenia Gravis	4.7%
287	Scrapie	4.7%
288	Central Cord Syndrome	4.7%
289	Lateral Medullary Syndrome	4.7%
290	Chorea	4.6%
291	Frontotemporal dementia	4.6%
292	Carotid Stenosis	4.6%
293	Intracranial Aneurysm	4.6%
294	Intracranial Arteriosclerosis	4.6%
295	Cerebral Atherosclerosis	4.6%
296	Subarachnoid Hemorrhage	4.6%
297	Cerebral Arteriosclerosis	4.6%
298	Cerebral Hemorrhage	4.6%
299	Cerebral Thrombosis	4.6%
300	Intracranial Embolism	4.6%
301	Intracranial Thrombosis	4.6%
302	Hermaphroditism	4.6%
303	Disorders of Sex Development	4.6%
304	Kallmann Syndrome	4.5%
305	granulosa cell tumor	4.5%
306	Carcinoma, Ovarian Epithelial	4.5%
307	Vertebral Artery Dissection	4.5%
308	MELAS Syndrome	4.4%
309	Kernicterus	4.4%
310	Brain Contusion	4.3%
311	Subarachnoid Hemorrhage, Traumatic	4.3%
312	Carotid Artery, Internal, Dissection	4.3%
313	Subclavian Steal Syndrome	4.3%
314	Pick Disease of the Brain	4.3%
315	Progressive bulbar palsy	4.2%
316	Bulbar palsy	4.2%
317	Subacute Sclerosing Panencephalitis	4.1%
318	Meningitis, Cryptococcal	4.1%
319	Sleep Disorders, Circadian Rhythm	4.1%
320	Meningitis, Listeria	4.1%
321	Meningitis, Haemophilus	4.1%
322	Meningitis, Pneumococcal	4.1%
323	Myopathy	4%
324	Optic Neuropathy	4%
325	Corpus Luteum Cyst	4%
326	Ovarian Cysts	4%
327	Guillain-Barre Syndrome	4%
328	Diabetic Nephropathy	4%
329	Lambert-Eaton Myasthenic Syndrome	4%
330	Klinefelter Syndrome	4%
331	Anovulation	3.9%
332	Diabetic Ketoacidosis	3.9%
333	Oophoritis	3.9%
334	Ataxia Telangiectasia	3.9%
335	Multiple Endocrine Neoplasia	3.9%
336	Pancreatic Neoplasm	3.9%
337	Botulism	3.9%
338	Torticollis	3.9%
339	Central Nervous System Cysts	3.9%
340	Facial Nerve Diseases	3.9%
341	Craniocerebral Trauma	3.9%
342	Parasomnia	3.9%
343	Dyssomnias	3.9%
344	Choroid Plexus Papilloma	3.9%
345	Brain Concussion	3.9%
346	Vestibulocochlear Nerve Diseases	3.8%
347	Decerebrate State	3.8%
348	Hemiparesis	3.8%
349	Hydranencephaly	3.8%
350	Meningism	3.8%
351	Neural Tube Defects	3.8%
352	Paresis	3.8%
353	Seizures	3.8%
354	Sensation Disorders	3.8%
355	Tethered Cord Syndrome	3.8%
356	Central Nervous System Neoplasms	3.8%
357	Complex partial seizures	3.8%
358	Iniencephaly	3.8%
359	Craniorachischisis	3.8%
360	Exencephaly	3.8%
361	Monoparesis	3.8%
362	Septo-Optic Dysplasia	3.8%
363	Cortical Dysplasia	3.8%
364	Neurogenic Inflammation	3.8%
365	Gait Disorders, Neurologic	3.8%
366	Neuromuscular Manifestations	3.8%
367	Malformations of Cortical Development	3.8%
368	Sweating, Gustatory	3.8%
369	Auriculotemporal Syndrome	3.8%
370	Carotid Artery Thrombosis	3.8%
371	Spinal Cord Ischemia	3.7%
372	Tuberculosis, Central Nervous System	3.7%
373	Causalgia	3.6%
374	Olfactory Nerve Injuries	3.6%
375	Giant Cell Arteritis	3.5%
376	Temporal Arteritis	3.5%
377	Cerebral Amyloid Angiopathy	3.4%
378	Sinus Thrombosis, Intracranial	3.4%
379	Leydig Cell Tumor	3.4%
380	Cryptorchidism	3.4%
381	Diabetic Retinopathy	3.4%
382	Alice in Wonderland Syndrome	3.4%
383	Horner Syndrome	3.3%
384	Multiple Sclerosis	3.3%
385	Reflex Sympathetic Dystrophy	3.3%
386	Nocturnal Myoclonus Syndrome	3.3%
387	Waterhouse-Friderichsen Syndrome	3.3%
388	Gonadal Dysgenesis	3.3%
389	Adrenogenital Syndrome	3.3%
390	Ovotesticular Disorders of Sex Development	3.3%
391	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.3%
392	Polycystic Ovary Syndrome	3.3%
393	Hyperandrogenism	3.2%
394	Pupil Disorders	3.2%
395	Neurobehavioral Manifestations	3.2%
396	Neuromyelitis Optica	3.1%
397	Paraneoplastic Encephalomyelitis	3.1%
398	Facial Nerve Injuries	3.1%
399	Uveomeningoencephalitic Syndrome	3.1%
400	Sturge-Weber Syndrome	3%
401	Vertigo	3%
402	Alcohol-Induced Disorders, Nervous System	3%
403	Refsum Disease	3%
404	Neuroaspergillosis	3%
405	Tardive Dyskinesia	2.9%
406	West Nile Fever	2.9%
407	Jet Lag Syndrome	2.9%
408	Galactosemias	2.8%
409	Urea Cycle Disorders, Inborn	2.8%
410	Tyrosinemias	2.8%
411	Multiple Endocrine Neoplasia Type 1	2.8%
412	Cavernous Sinus Thrombosis	2.8%
413	Sagittal Sinus Thrombosis	2.8%
414	Ophthalmoplegia	2.8%
415	External Ophthalmoplegia	2.8%
416	Neuritis	2.8%
417	Polyneuritis	2.8%
418	Radiculitis	2.8%
419	Polyneuropathy	2.8%
420	Mononeuritis	2.8%
421	Mononeuropathies	2.8%
422	Brachial Plexus Neuropathies	2.8%
423	Radiculopathy	2.8%
424	Mononeuropathy Multiplex	2.8%
425	Nerve Root Compression	2.8%
426	Hematoma, Subdural	2.7%
427	Hematoma, Epidural, Cranial	2.7%
428	Myasthenia Gravis, Autoimmune, Experimental	2.7%
429	Acrodynia	2.6%
430	Tuberous Sclerosis	2.6%
431	Pseudorabies	2.6%
432	Fabry Disease	2.6%
433	Voice Disorders	2.6%
434	Voice Disturbance	2.6%
435	Homocystinuria	2.5%
436	Smith-Magenis syndrome	2.5%
437	Leigh Disease	2.5%
438	Dural Arteriovenous Fistula	2.5%
439	Brachial Plexus Neuritis	2.5%
440	Neuralgic Amyotrophy	2.5%
441	Anterior Spinal Artery Syndrome	2.5%
442	Neurosyphilis	2.5%
443	Vocal Cord Paralysis	2.4%
444	Charcot-Marie-Tooth Disease	2.3%
445	Myotonia Congenita	2.2%
446	Cerebrospinal Fluid Otorrhea	2.2%
447	Cerebrospinal Fluid Rhinorrhea	2.2%
448	Neuritis, Autoimmune, Experimental	2.2%
449	Gait Ataxia	2.2%
450	Carcinoma, Pancreatic Ductal	2.2%
451	Menkes Kinky Hair Syndrome	2.2%
452	Hematoma, Subdural, Intracranial	2.2%
453	Hematoma, Subdural, Chronic	2.2%
454	Hematoma, Subdural, Acute	2.2%
455	Turner Syndrome	2.2%
456	Coma, Post-Head Injury	2.1%
457	Reflex, Abnormal	2.1%
458	Hyporeflexia	2.1%
459	Hyperreflexia	2.1%
460	Myositis	2.1%
461	Optic Atrophy	2.1%
462	Optic Neuritis	2.1%
463	Papilledema	2.1%
464	Strabismus	2.1%
465	Tolosa-Hunt Syndrome	2.1%
466	Isaacs syndrome	2.1%
467	Arsenic Poisoning	2.1%
468	Myotonic Disorders	2.1%
469	Myasthenic Syndromes, Congenital	2.1%
470	Lyme Neuroborreliosis	2.1%
471	Facial Injuries	2.1%
472	Facial Neuralgia	2.1%
473	Sleep Talking	2.1%
474	Manganese Poisoning	2.1%
475	Sleep Disorders, Intrinsic	2.1%
476	Orthostatic intolerance	2.1%
477	Anosmia	2.1%
478	Ataxia	2.1%
479	Athetosis	2.1%
480	Catalepsy	2.1%
481	Dystonia	2.1%
482	Hemiplegia	2.1%
483	Locked-In Syndrome	2.1%
484	Meningeal Neoplasms	2.1%
485	Meningomyelocele	2.1%
486	Muscle Hypertonia	2.1%
487	Muscle hypotonia	2.1%
488	Myoclonus	2.1%
489	Myotonia	2.1%
490	Neuralgia	2.1%
491	Paraplegia	2.1%
492	Pseudobulbar Palsy	2.1%
493	Quadriplegia	2.1%
494	Spasm	2.1%
495	Spastic Paraplegia	2.1%
496	Status Epilepticus	2.1%
497	Taste Disorders	2.1%
498	Tremor	2.1%
499	Spina Bifida	2.1%
500	Monoplegia	2.1%
501	Hypokinesia	2.1%
502	Paraparesis	2.1%
503	Bradykinesia	2.1%
504	Waxy flexibility	2.1%
505	Action Tremor	2.1%
506	Resting Tremor	2.1%
507	Dysosmia	2.1%
508	Quadriparesis	2.1%
509	Mercury Poisoning, Nervous System	2.1%
510	Olfaction Disorders	2.1%
511	Myokymia	2.1%
512	Lead Poisoning, Nervous System	2.1%
513	Vestibular Neuronitis	2.1%
514	Somatosensory Disorders	2.1%
515	Neuropathic pain	2.1%
516	Hyperkinesia	2.1%
517	Intention tremor	2.1%
518	Alcohol Withdrawal Seizures	2.1%
519	Tarsal Tunnel Syndrome	2%
520	Cauda Equina Syndrome	2%
521	insulinoma	2%
522	Gastrinoma	2%
523	Glucagonoma	2%
524	Carcinoma, Endometrioid	2%
525	Toxoplasmosis, Congenital	2%
526	Malaria, Cerebral	2%
527	Neurocysticercosis	2%
528	Multiple Sclerosis, Chronic Progressive	2%
529	Multiple Sclerosis, Relapsing-Remitting	2%
530	Zellweger Syndrome	1.9%
531	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.9%
532	Akathisia	1.9%
533	Restlessness	1.9%
534	Psychomotor Agitation	1.9%
535	Myotonic Dystrophy	1.8%
536	Renal Osteodystrophy	1.8%
537	Renal rickets	1.8%
538	Vipoma	1.8%
539	Hand-Arm Vibration Syndrome	1.8%
540	Vision Disorders	1.7%
541	Metamorphopsia	1.7%
542	Visual Impairment	1.7%
543	Fibromyalgia	1.7%
544	Optic Neuropathy, Ischemic	1.7%
545	Anterior Ischemic Optic Neuropathy	1.7%
546	Medial Tibial Stress Syndrome	1.7%
547	Facial Hemiatrophy	1.7%
548	Melkersson-Rosenthal Syndrome	1.7%
549	Mitochondrial Myopathies	1.7%
550	Glycogen storage disease type II	1.7%
551	Anisocoria	1.7%
552	Confusion	1.7%
553	Facial paralysis	1.7%
554	Lethargy	1.7%
555	Memory Disorders	1.7%
556	Muscle Cramp	1.7%
557	Perceptual Disorders	1.7%
558	Psychomotor Disorders	1.7%
559	Tonic Pupil	1.7%
560	Eosinophilia-Myalgia Syndrome	1.7%
561	Anhedonia	1.7%
562	Disorientation	1.7%
563	Facial Paresis	1.7%
564	Memory Loss	1.7%
565	Hemisensory Neglect	1.7%
566	Dysacusis	1.7%
567	Sleep Bruxism	1.7%
568	Anencephaly	1.7%
569	Meningocele	1.7%
570	Muscular Atrophy	1.7%
571	Respiratory Paralysis	1.7%
572	Encephalocele	1.7%
573	Sciatic Neuropathy	1.7%
574	Ulnar Neuropathies	1.7%
575	Lesion of Sciatic Nerve	1.7%
576	Ulnar Neuritis	1.7%
577	Radial nerve compression	1.7%
578	Radial Tunnel Syndrome	1.7%
579	Peroneal Neuropathies	1.7%
580	Radial Neuropathy	1.7%
581	Median Neuropathy	1.7%
582	Sciatic Nerve Palsy	1.7%
583	Femoral Neuropathy	1.7%
584	Tibial Neuropathy	1.7%
585	Ulnar Nerve Palsy	1.7%
586	Postural Orthostatic Tachycardia Syndrome	1.7%
587	Radial nerve palsy	1.7%
588	Tetany	1.7%
589	Carpal Tunnel Syndrome	1.6%
590	neurofibroma	1.6%
591	Gait Apraxia	1.6%
592	Sciatica	1.6%
593	Alstrom Syndrome	1.5%
594	Acoustic Neuroma	1.5%
595	Optic Nerve Glioma	1.5%
596	Amyloid Neuropathies, Familial	1.5%
597	Duane Retraction Syndrome	1.4%
598	Consciousness Disorders	1.4%
599	Mental Retardation	1.4%
600	Muscle Weakness	1.4%
601	Depressed Level of Consciousness	1.4%
602	Mental deficiency	1.4%
603	Intellectual Disability	1.4%
604	Mobius Syndrome	1.4%
605	Bell Palsy	1.4%
606	Catatonia	1.4%
607	Herpes Zoster Oticus	1.4%
608	Familial Periodic Paralysis	1.4%
609	Aphonia	1.4%
610	Sleep Deprivation	1.4%
611	Dysphonia	1.4%
612	Cubital Tunnel Syndrome	1.3%
613	Gaucher Disease	1.3%
614	Thoracic Outlet Syndrome	1.3%
615	Esotropia	1.2%
616	Exotropia	1.2%
617	Hypotension, Orthostatic	1.2%
618	Sleep Apnea Syndromes	1.2%
619	Polymyositis	1.2%
620	Post-Exercise Hypotension	1.2%
621	Disorders of Excessive Somnolence	1.2%
622	Sleep Initiation and Maintenance Disorders	1.2%
623	Night Terrors	1.2%
624	Somnambulism	1.2%
625	Trigeminal Nerve Disorder	1.2%
626	Transient Insomnia	1.2%
627	Sleep Paralysis	1.2%
628	Chronic Insomnia	1.2%
629	REM Sleep Behavior Disorder	1.2%
630	Hypersomnia	1.2%
631	Dermal Sinus	1.2%
632	Dysgeusia	1.2%
633	Formication	1.2%
634	Hyperalgesia	1.2%
635	Hyperesthesia	1.2%
636	Hypesthesia	1.2%
637	Language Disorders	1.2%
638	Numbness	1.2%
639	Paresthesia	1.2%
640	Paraparesis, Spastic	1.2%
641	Spina Bifida Cystica	1.2%
642	Trismus	1.2%
643	Spina Bifida Occulta	1.2%
644	Epilepsia Partialis Continua	1.2%
645	Hypogeusia	1.2%
646	Meningeal Carcinomatosis	1.2%
647	Brown-Sequard Syndrome	1.2%
648	Lissencephaly	1.2%
649	Polymicrogyria	1.2%
650	Pachygyria	1.2%
651	Schizencephaly	1.2%
652	Lockjaw	1.2%
653	Allodynia	1.2%
654	Lead Poisoning, Nervous System, Childhood	1.2%
655	Lead Poisoning, Nervous System, Adult	1.2%
656	Periventricular Nodular Heterotopia	1.2%
657	Ageusia	1.2%
658	Myalgia	1.2%
659	Neuronal Ceroid-Lipofuscinoses	1.2%
660	Classical Lissencephalies and Subcortical Band Heterotopias	1.2%
661	Denys-Drash Syndrome	1.2%
662	Polyradiculopathy	1.1%
663	Tay-Sachs Disease	1.1%
664	Aicardi's syndrome	1.1%
665	Hoarseness	1%
666	Niemann-Pick Disease, Type C	1%
667	Cockayne Syndrome	1%
668	Alcohol Withdrawal Delirium	1%
669	Eye Injuries	1%
670	Muscular Dystrophy	1%
671	Congenital nystagmus	1%
672	Orbital Myositis	1%
673	Diplopia	1%
674	Muscle Rigidity	1%
675	Muscle Spasticity	1%
676	Scotoma	1%
677	Photophobia	1%
678	Cogwheel Rigidity	1%
679	Hemifacial Spasm	1%
680	Amaurosis	1%
681	Blindness	1%
682	Nuchal Rigidity	1%
683	Pyomyositis	1%
684	Agnosia	1%
685	Apraxias	1%
686	Hallucinations	1%
687	Hemianopsia	1%
688	Hyperacusis	1%
689	Tinnitus	1%
690	Visual Agnosia	1%
691	Anosognosia	1%
692	Wernicke-Korsakoff Syndrome	1%
693	Phonophobia	1%
694	Hearing Loss	1%
695	Sarcopenia	1%
696	Alexia	0.9%
697	Dyslexia	0.9%
698	Holoprosencephaly	0.9%
699	Optic Atrophy, Hereditary, Leber	0.9%
700	Amnesia	0.8%
701	Delirium	0.8%
702	Dissociative Amnesia	0.8%
703	Color blindness	0.8%
704	Global Amnesia	0.8%
705	Cri-du-Chat Syndrome	0.8%
706	Down Syndrome	0.8%
707	Trisomy 21	0.8%
708	POEMS Syndrome	0.8%
709	Meningioma	0.8%
710	Williams Syndrome	0.8%
711	Microcephaly	0.8%
712	Macrocephaly	0.8%
713	Sleep Apnea, Obstructive	0.8%
714	Sleep Apnea, Central	0.8%
715	Hypokalemic periodic paralysis	0.8%
716	Narcolepsy	0.8%
717	Trigeminal Neuralgia	0.8%
718	Kleine-Levin Syndrome	0.8%
719	Agraphia	0.8%
720	Anomia	0.8%
721	Cluttering	0.8%
722	Language Development Disorders	0.8%
723	Speech Disorders	0.8%
724	Syncope	0.8%
725	Stupor	0.8%
726	Dysgraphia	0.8%
727	Presyncope	0.8%
728	Dyslalia	0.8%
729	Porencephaly	0.8%
730	Kearns-Sayre syndrome	0.8%
731	Neurofibrosarcoma	0.8%
732	Prader-Willi Syndrome	0.7%
733	Phantom pain	0.7%
734	Phantom Limb Pain	0.7%
735	Eye Burns	0.7%
736	Welander Distal Myopathy	0.7%
737	Amaurosis Fugax	0.7%
738	Blindness, Cortical	0.7%
739	Dyscalculia	0.7%
740	Rett Syndrome	0.7%
741	Deafness	0.7%
742	Hearing Loss, Sudden	0.7%
743	Gerstmann Syndrome	0.7%
744	Hearing Loss, Bilateral	0.7%
745	Hearing Loss, High-Frequency	0.7%
746	Hearing Loss, Mixed Conductive-Sensorineural	0.7%
747	Prosopagnosia	0.7%
748	Apraxia, Ideomotor	0.7%
749	Charles Bonnet Syndrome	0.7%
750	Hearing Loss, Unilateral	0.7%
751	Complete Hearing Loss	0.7%
752	Alien Hand Syndrome	0.7%
753	Deaf Mutism	0.7%
754	Cataplexy	0.6%
755	Aphasia	0.6%
756	Articulation Disorders	0.6%
757	Echolalia	0.6%
758	Stuttering	0.6%
759	Dysphasia	0.6%
760	Dermatomyositis	0.6%
761	Corneal Scar	0.6%
762	Rubinstein-Taybi Syndrome	0.6%
763	Muscular Dystrophy, Duchenne	0.5%
764	Retrograde amnesia	0.5%
765	Amnesia, Anterograde	0.5%
766	Dysarthria	0.5%
767	Mutism	0.5%
768	Selective Mutism	0.5%
769	Fragile X Syndrome	0.5%
770	Corneal Perforation	0.4%
771	Alexia, Pure	0.4%
772	Mucopolysaccharidosis II	0.3%

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