MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Bloom Syndrome

(UMLS:C0005859)

Definition:: An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.
UMLS ID:: C0005859
MeSH ID:: D001816

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.137

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.284.100

Synonym(s)

Bloom Syndrome

BLOOM SYNDROME

BS - Bloom syndrome

Bloom

Bloom syndrome

Bloom's syndrome

Bloom-Torre-Machacek syndrome

Congenital Telangiectatic Erythema Syndrome

Congenital telangiectatic erythema syndrome

10.

bloom syndrome

11.

bloom's syndrome

12.

blooms syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Aripiprazole	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Prune Belly Syndrome	31.1%
2	Waardenburg Syndrome	31.1%
3	Beckwith-Wiedemann Syndrome	29.3%
4	Wolf-Hirschhorn Syndrome	29.3%
5	Werner Syndrome	28.8%
6	Cockayne Syndrome	26.6%
7	Smith-Lemli-Opitz Syndrome	24.9%
8	Smith-Magenis syndrome	24.7%
9	Cri-du-Chat Syndrome	24.3%
10	Down Syndrome	24.3%
11	Trisomy 21	24.3%
12	CHARGE Syndrome	23%
13	Holoprosencephaly	22.8%
14	Prader-Willi Syndrome	22.2%
15	Ectodermal Dysplasia	21%
16	Aplasia Cutis Congenita	21%
17	Wasting Syndrome	20.7%
18	Abnormalities, Drug-Induced	20.5%
19	Acid-Base Imbalance	20.5%
20	Calcium Metabolism Disorders	20.5%
21	Iron Metabolism Disorders	20.5%
22	Phosphorus Metabolism Disorders	20.5%
23	Situs Inversus	20.5%
24	Water-Electrolyte Imbalance	20.5%
25	Lipid Metabolism Disorders	20.5%
26	Mitochondrial Diseases	20.5%
27	Glucose Metabolism Disorders	20.5%
28	Hypercalcemia	20%
29	Hypocalcemia	20%
30	Milk-Alkali Syndrome	20%
31	Rubinstein-Taybi Syndrome	19.4%
32	Nail-Patella Syndrome	19.3%
33	Mobius Syndrome	19.1%
34	Polycystic Kidney Diseases	17.5%
35	Fanconi Anemia	17.5%
36	Pseudohypoparathyroidism	17%
37	Zellweger Syndrome	16.7%
38	Marfan Syndrome	16.1%
39	Eye Abnormalities	16.1%
40	Cardiovascular Abnormalities	16.1%
41	Lipodystrophy	16%
42	Osteopenia	15.5%
43	Skin Abnormalities	15.5%
44	Lymphatic Abnormalities	15.5%
45	Congenital Microtia	15.5%
46	Leigh Disease	15.5%
47	Brain Diseases, Metabolic, Inborn	15.5%
48	POEMS Syndrome	15.4%
49	Brain Diseases, Metabolic	15.3%
50	Congenital diaphragmatic hernia	15.1%
51	Primary Ciliary Dyskinesia	14.8%
52	Aicardi's syndrome	14.8%
53	Xeroderma Pigmentosum	14.8%
54	Rickets	14.4%
55	Hyperhomocysteinemia	14.3%
56	Carbamoyl-Phosphate Synthase I Deficiency Disease	14.1%
57	Anencephaly	13.9%
58	Hyperlipoproteinemia Type IV	13.7%
59	Hyperlipoproteinemia Type V	13.7%
60	Hypolipoproteinemias	13.7%
61	Congenital Hyperinsulinism	13.5%
62	Galactosemias	13.4%
63	Urea Cycle Disorders, Inborn	13.4%
64	Tyrosinemias	13.4%
65	Acidosis	13.3%
66	Alkalosis	13.3%
67	Amino Acid Metabolism, Inborn Errors	13.3%
68	Amyloidosis	13.3%
69	Calcinosis	13.3%
70	Carbohydrate Metabolism, Inborn Errors	13.3%
71	Hyperglycemia	13.3%
72	Hyperinsulinism	13.3%
73	Hyperkalemia	13.3%
74	Hypernatremia	13.3%
75	Hypoglycemia	13.3%
76	Hypokalemia	13.3%
77	Hyponatremia	13.3%
78	Metal Metabolism, Inborn Errors	13.3%
79	Progeria	13.3%
80	Twins, Conjoined	13.3%
81	Xanthomatosis	13.3%
82	Lysosomal Storage Diseases	13.3%
83	Hypophosphatemia	13.3%
84	Metabolic acidosis	13.3%
85	Dyslipidemias	13.3%
86	Cytochrome-c Oxidase Deficiency	13.3%
87	Iron Overload	13.3%
88	Peroxisomal Disorders	13.3%
89	Xanthoma	13.3%
90	Kartagener Syndrome	13.1%
91	Lactose Intolerance	13.1%
92	Polycystic Kidney, Autosomal Dominant	13%
93	Urogenital Abnormalities	12.9%
94	Ataxia Telangiectasia	12.7%
95	Hyperlipidemia, Familial Combined	12.7%
96	Hyperlipoproteinemia Type III	12.2%
97	Glycogen storage disease type II	12%
98	Gaucher Disease	11.9%
99	Genetic Diseases, Inborn	11.9%
100	Nutrition Disorders	11.9%
101	Hyperphosphaturia	11.9%
102	Alstrom Syndrome	11.9%
103	Familial Hypophosphatemic Rickets	11.9%
104	Maxillofacial Abnormalities	11.7%
105	Dural Arteriovenous Fistula	11.7%
106	Dextrocardia	11.6%
107	Hypoalphalipoproteinemias	11.3%
108	Homocystinuria	11.3%
109	Amyloid Neuropathies, Familial	11.2%
110	Refsum Disease	11.2%
111	Osteomalacia	10.9%
112	Diabetic Ketoacidosis	10.8%
113	Neuronal Ceroid-Lipofuscinoses	10.7%
114	Tay-Sachs Disease	10.7%
115	Sjogren-Larsson Syndrome	10.7%
116	Menkes Kinky Hair Syndrome	10.5%
117	Diabetes Mellitus	10.5%
118	Nesidioblastosis	10.4%
119	Fabry Disease	10.3%
120	Niemann-Pick Disease, Type C	10.2%
121	Anophthalmos	10.2%
122	Anus, Imperforate	10.2%
123	Dehydration	10.2%
124	Hydranencephaly	10.2%
125	Lipomatosis	10.2%
126	Microphthalmos	10.2%
127	Neural Tube Defects	10.2%
128	Water Intoxication	10.2%
129	Tethered Cord Syndrome	10.2%
130	Iniencephaly	10.2%
131	Craniorachischisis	10.2%
132	Limb Deformities, Congenital	10.2%
133	Exencephaly	10.2%
134	Septo-Optic Dysplasia	10.2%
135	Craniofacial Abnormalities	10.2%
136	Cortical Dysplasia	10.2%
137	Malformations of Cortical Development	10.2%
138	Anorectal Malformations	10.2%
139	Adrenoleukodystrophy	10.1%
140	Xeroderma	10.1%
141	Achlorhydria	10%
142	Osteoporosis	10%
143	Bone Demineralization, Pathologic	10%
144	Post-Traumatic Osteoporosis	10%
145	Celiac Disease	9.9%
146	Sprue, Tropical	9.9%
147	Steatorrhea	9.9%
148	Sprue	9.9%
149	Acidosis, Lactic	9.9%
150	Calciphylaxis	9.9%
151	Hemosiderosis	9.9%
152	Ketosis	9.9%
153	Ketonuria	9.9%
154	Ketoacidosis	9.9%
155	Ketonemia	9.9%
156	Vascular calcification	9.9%
157	Mitochondrial Encephalomyopathies	9.9%
158	Ichthyosis, X-Linked	9.9%
159	Alkaptonuria	9.8%
160	Glycogen Storage Disease	9.8%
161	Hypophosphatasia	9.8%
162	Propionic acidemia	9.8%
163	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
164	Cystinosis	9.8%
165	Antley-Bixler Syndrome Phenotype	9.8%
166	Renal tubular acidosis	9.7%
167	Basal Cell Nevus Syndrome	9.6%
168	Hepatolenticular Degeneration	9.4%
169	Mucopolysaccharidosis III	9.2%
170	Microcephaly	9%
171	Macrocephaly	9%
172	Porphyrias, Hepatic	9%
173	Scimitar Syndrome	8.9%
174	Fetal Diseases	8.9%
175	Williams Syndrome	8.8%
176	Abnormalities, Radiation-Induced	8.6%
177	Craniosynostosis	8.4%
178	Syndactyly	8.4%
179	Brachycephaly	8.4%
180	Mucopolysaccharidosis II	8.4%
181	MELAS Syndrome	8.4%
182	Fragile X Syndrome	8.4%
183	Blepharophimosis	8.2%
184	Laryngostenosis	8.2%
185	Mouth Abnormalities	8.2%
186	Hypercholesterolemia	8.2%
187	Hyperlipoproteinemias	8.2%
188	Hypertriglyceridemia	8.2%
189	Glycogen Storage Disease Type I	8.1%
190	Glycogen Storage Disease Type V	8.1%
191	Esophageal Atresia	8.1%
192	Intestinal Atresia	8.1%
193	Mitochondrial Myopathies	8.1%
194	Horseshoe Kidney	8.1%
195	Pectus excavatum	8.1%
196	Porencephaly	8.1%
197	Klippel-Feil Syndrome	8.1%
198	Myelinolysis, Central Pontine	8.1%
199	Gastroschisis	8.1%
200	Synostosis	8.1%
201	Acrocephalosyndactylia	8%
202	Acrodermatitis	8%
203	Lymphangiectasis, Intestinal	8%
204	Gianotti-Crosti Syndrome	8%
205	Classical Lissencephalies and Subcortical Band Heterotopias	8%
206	Glycosuria	7.9%
207	Reye Syndrome	7.9%
208	Hepatic Encephalopathy	7.9%
209	Retinal Dysplasia	7.8%
210	Aniridia	7.8%
211	Epidermolysis Bullosa	7.6%
212	Glycosuria, Renal	7.6%
213	HIV Wasting Syndrome	7.5%
214	Noonan Syndrome	7.5%
215	Acidosis, Respiratory	7.4%
216	Adiposis Dolorosa	7.4%
217	Alkalosis, Respiratory	7.4%
218	Amelia	7.4%
219	Arachnodactyly	7.4%
220	Ectopia Cordis	7.4%
221	Ectromelia	7.4%
222	Hemimelia	7.4%
223	Meningomyelocele	7.4%
224	Phocomelia	7.4%
225	Sirenomelia	7.4%
226	Spina Bifida	7.4%
227	Polydactyly	7.4%
228	Brachydactyly	7.4%
229	Plagiocephaly	7.4%
230	Lower Extremity Deformities, Congenital	7.4%
231	Upper Extremity Deformities, Congenital	7.4%
232	Single umbilical artery	7.4%
233	Albinism	7.4%
234	Insulin Resistance	7.4%
235	Osteoporosis, Postmenopausal	7.4%
236	HIV-Associated Lipodystrophy Syndrome	7.3%
237	Turner Syndrome	7.3%
238	Renal Osteodystrophy	7.3%
239	Renal rickets	7.3%
240	Friedreich Ataxia	7%
241	Canavan Disease	7%
242	Alexander Disease	7%
243	Cystic Fibrosis	7%
244	Poland Syndrome	6.9%
245	Cleft Palate	6.9%
246	Arthrogryposis	6.9%
247	Choanal Atresia	6.9%
248	Tracheobronchomegaly	6.9%
249	Laryngocele	6.9%
250	Jaw Abnormalities	6.9%
251	Abdominal Cramps	6.8%
252	Amniotic Band Syndrome	6.8%
253	Asphyxia Neonatorum	6.8%
254	Child Nutrition Disorders	6.8%
255	Choledochal Cyst	6.8%
256	Hermaphroditism	6.8%
257	Hypervitaminosis A	6.8%
258	Infant Nutrition Disorders	6.8%
259	Infant, Premature, Diseases	6.8%
260	Disorders of Sex Development	6.8%
261	Malnutrition	6.8%
262	Infantile Colic	6.8%
263	Cryptorchidism	6.7%
264	Hypospadias	6.7%
265	Central Nervous System Cysts	6.7%
266	Kernicterus	6.7%
267	Dandy-Walker Syndrome	6.7%
268	Familial Periodic Paralysis	6.7%
269	Wernicke Encephalopathy	6.6%
270	Necrobiosis Lipoidica Diabeticorum	6.6%
271	Variegate Porphyria	6.6%
272	Acute intermittent porphyria	6.6%
273	Porphyria Cutanea Tarda	6.6%
274	Optic Atrophy, Hereditary, Leber	6.5%
275	Renal Aminoacidurias	6.5%
276	Fanconi Syndrome	6.5%
277	Pseudohypoaldosteronism	6.5%
278	Liddle Syndrome	6.5%
279	Klinefelter Syndrome	6.3%
280	Dermal Sinus	6.1%
281	Spina Bifida Cystica	6.1%
282	Spina Bifida Occulta	6.1%
283	Gestational Diabetes	6.1%
284	Lissencephaly	6.1%
285	Polymicrogyria	6.1%
286	Pachygyria	6.1%
287	Schizencephaly	6.1%
288	Latent Autoimmune Diabetes in Adults	6.1%
289	Periventricular Nodular Heterotopia	6.1%
290	Diabetes Mellitus, Experimental	6%
291	Aortic coarctation	6%
292	Cor Triatriatum	6%
293	Coronary Vessel Anomalies	6%
294	Dental Enamel Hypoplasia	6%
295	Patent ductus arteriosus	6%
296	Ebstein Anomaly	6%
297	Heart Septal Defects	6%
298	Hypodontia	6%
299	Macrostomia	6%
300	Meningocele	6%
301	Microstomia	6%
302	Tetralogy of Fallot	6%
303	Transposition of Great Vessels	6%
304	Hypoplastic Left Heart Syndrome	6%
305	May-Thurner Syndrome	6%
306	Encephalocele	6%
307	Pseudoxanthoma Elasticum	5.9%
308	Craniofacial Dysostosis	5.9%
309	Nephrocalcinosis	5.9%
310	Tetany	5.9%
311	Meconium Aspiration Syndrome	5.9%
312	Wolff-Parkinson-White Syndrome	5.9%
313	Laryngomalacia	5.9%
314	Cerebral Amyloid Angiopathy	5.8%
315	Pectus carinatum	5.8%
316	Micrognathism	5.8%
317	Pierre Robin Syndrome	5.8%
318	Bladder Exstrophy	5.7%
319	Epispadias	5.7%
320	Gout	5.7%
321	Multicystic Dysplastic Kidney	5.7%
322	Charcot-Marie-Tooth Disease	5.6%
323	Kallmann Syndrome	5.6%
324	Hyperkeratosis, Epidermolytic	5.5%
325	Hypokalemic periodic paralysis	5.4%
326	Cystinuria	5.4%
327	Neoplastic Syndromes, Hereditary	5.4%
328	Kearns-Sayre syndrome	5.3%
329	Retrognathia	5.2%
330	Anemia, Neonatal	5.1%
331	Multiple Epiphyseal Dysplasia	5.1%
332	Osteochondrodysplasias	5.1%
333	Pelger-Huet Anomaly	5.1%
334	Persistent Fetal Circulation Syndrome	5.1%
335	Myasthenic Syndromes, Congenital	5.1%
336	Umbilical hernia	5%
337	Long QT Syndrome	5%
338	Platybasia	5%
339	Tricuspid Atresia	5%
340	Primary amyloidosis	5%
341	Arrhythmogenic Right Ventricular Dysplasia	5%
342	Gonadal Dysgenesis	4.9%
343	Bronchomalacia	4.9%
344	Adrenogenital Syndrome	4.9%
345	Tracheomalacia	4.9%
346	Ovotesticular Disorders of Sex Development	4.9%
347	Aortopulmonary Septal Defect	4.9%
348	Double Outlet Right Ventricle	4.9%
349	Endocardial Cushion Defects	4.9%
350	Myocardial bridging	4.9%
351	Aorticopulmonary Septal Defect	4.9%
352	Hyperandrogenism	4.8%
353	Tuberous Sclerosis	4.8%
354	Prognathism	4.7%
355	Arthritis, Gouty	4.7%
356	Deficiency Diseases	4.4%
357	Familial Mediterranean Fever	4.4%
358	Starvation	4.4%
359	Refeeding Syndrome	4.4%
360	Anemia, Sickle Cell	4.4%
361	Thalassemia	4.4%
362	Muscular Dystrophy, Duchenne	4.4%
363	Truncus Arteriosus, Persistent	4.4%
364	Goldenhar Syndrome	4.4%
365	Amyotrophic Lateral Sclerosis	4.3%
366	Dwarfism	4.2%
367	Neonatal Abstinence Syndrome	4.2%
368	Mandibulofacial Dysostosis	4.1%
369	Romano-Ward Syndrome	4.1%
370	Fetal Growth Retardation	4.1%
371	Frontotemporal dementia	4.1%
372	Muscular Dystrophy	4%
373	Osteogenesis Imperfecta	4%
374	Fetal Hypoxia	4%
375	Congenital nystagmus	4%
376	Fetal Alcohol Spectrum Disorders	4%
377	Toxoplasmosis, Congenital	4%
378	Syphilis, Congenital	4%
379	Rett Syndrome	3.9%
380	Talipes	3.7%
381	CREST Syndrome	3.7%
382	Congenital clubfoot	3.4%
383	Vertical Talus	3.4%
384	Autoimmune Lymphoproliferative Syndrome	3.4%
385	Paralysis, Obstetric	3.4%
386	Retinopathy of Prematurity	3.4%
387	Chorioamnionitis	3.4%
388	Angioedemas, Hereditary	3.3%
389	Bronchopulmonary Dysplasia	3.3%
390	Wiskott-Aldrich Syndrome	3.3%
391	Kwashiorkor	3.3%
392	Magnesium Deficiency	3.3%
393	Potassium Deficiency	3.3%
394	Protein Deficiency	3.3%
395	Avitaminosis	3.3%
396	Sickle Cell Trait	3.2%
397	Arteriovenous fistula	3.1%
398	Myotonic Dystrophy	2.9%
399	Respiratory Distress Syndrome, Newborn	2.7%
400	Ascorbic Acid Deficiency	2.7%
401	Vitamin A Deficiency	2.7%
402	Vitamin D Deficiency	2.7%
403	Vitamin E Deficiency	2.7%
404	Marasmus	2.7%
405	Cutis Laxa	2.7%
406	Retinitis Pigmentosa	2.7%
407	Pigmentary retinopathy	2.7%
408	Porokeratosis	2.7%
409	Keratoderma, Palmoplantar	2.7%
410	Chronic granulomatous disease	2.6%
411	Welander Distal Myopathy	2.6%
412	Acute Chest Syndrome	2.5%
413	Ophthalmia Neonatorum	2.5%
414	Folic Acid Deficiency	2.5%
415	Pellagra	2.5%
416	Thiamine Deficiency	2.5%
417	Vitamin B 12 Deficiency	2.5%
418	Vitamin B 6 Deficiency	2.5%
419	Pyridoxine Deficiency	2.5%
420	Denys-Drash Syndrome	2.4%
421	Hydrops Fetalis	2.4%
422	Beriberi	2.3%
423	Duane Retraction Syndrome	2.3%
424	Peutz-Jeghers Syndrome	2.2%
425	Myotonia Congenita	2.2%
426	Thrombasthenia	2.2%
427	Antithrombin III Deficiency	2.2%
428	Protein C Deficiency	2.2%
429	Afibrinogenemia	2.2%
430	Dystonia Musculorum Deformans	2.2%
431	Factor VII Deficiency	2.2%
432	Factor X Deficiency	2.2%
433	Factor XII Deficiency	2.2%
434	Hemophilia A	2.2%
435	Leukomalacia, Periventricular	2.2%
436	Activated Protein C Resistance	2.2%
437	Factor II deficiency	2.2%
438	Factor VIII Deficiency	2.2%
439	Factor V deficiency	2.2%
440	Factor XI Deficiency	2.2%
441	Hypoprothrombinemias	2.2%
442	Lafora Disease	2.2%
443	Unverricht-Lundborg Syndrome	2.2%
444	Anemia, Diamond-Blackfan	2.2%
445	Obesity	2.2%
446	Hyaline Membrane Disease	2%
447	Multiple Endocrine Neoplasia	2%
448	Papillon-Lefevre Disease	2%
449	Obesity, Abdominal	1.9%
450	Congenital Hypothyroidism	1.9%
451	Dermatitis, Atopic	1.9%
452	Anemia, Pernicious	1.7%
453	Behcet Syndrome	1.7%
454	Vitamin K Deficiency	1.7%
455	Pediatric Obesity	1.6%
456	Scurvy	1.5%
457	Huntington Disease	1.5%
458	Multiple Endocrine Neoplasia Type 1	1.4%
459	Nephroblastoma	1.3%
460	Adenomatous Polyposis Coli	1.2%
461	Subacute Combined Degeneration	1%

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