MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperkeratosis, Epidermolytic

(UMLS:C0079153)

Definition:: A form of congenital ichthyosis inherited as an autosomal dominant trait and characterized by ERYTHRODERMA and severe hyperkeratosis. It is manifested at birth by blisters followed by the appearance of thickened, horny, verruciform scales over the entire body, but accentuated in flexural areas. Mutations in the genes that encode KERATIN-1 and KERATIN-10 have been associated with this disorder.
UMLS ID:: C0079153
MeSH ID:: D017488

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.831.512.400.375|C16.320.850.400.375|C16.614.492.400.375

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.428.333.250.375|C17.800.804.512.400.375|C17.800.827.400.375

Synonym(s)

Hyperkeratosis, Epidermolytic

BIE - Bullous ichthyosiform erythroderma

Bullous congenital ichthyosiform erythroderma

Bullous ichthyosiform erythroderma

Bullous ichthyosis

Congenital bullous ichthyosiform erythroderma

Congenital ichthyosiform erythroderma, bullous

Dominant ichthyosis vulgaris

EPIDERMOLYTIC HYPERKERATOSIS

10.

Epidermolytic Hyperkeratosis

11.

Epidermolytic hyperkeratosis

12.

Epidermolytic palmoplantar hyperkeratosis

13.

Hyperkeratosis, epidermolytic

14.

epidermolytic hyperkeratosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Arsenicals		17050553	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Ichthyosis, X-Linked	44.4%
2	Epidermolysis Bullosa	42.7%
3	Sjogren-Larsson Syndrome	40.6%
4	Ectodermal Dysplasia	39.6%
5	Aplasia Cutis Congenita	39.6%
6	Xeroderma Pigmentosum	39.5%
7	Porokeratosis	34.8%
8	Keratoderma, Palmoplantar	34.8%
9	Pseudoxanthoma Elasticum	33.8%
10	Dermatitis, Atopic	32.7%
11	Acrodermatitis	29.4%
12	Gianotti-Crosti Syndrome	29.4%
13	Cutis Laxa	27.8%
14	Pyoderma Gangrenosum	25.9%
15	Albinism	25.5%
16	Lupus Erythematosus, Cutaneous	23%
17	Panniculitis	23%
18	Systemic Scleroderma	23%
19	Morphea	23%
20	Papillon-Lefevre Disease	21.9%
21	Porphyrias, Hepatic	20.5%
22	Nail-Patella Syndrome	20.4%
23	Breast Diseases	19.5%
24	Dermatitis	19.5%
25	Exanthema	19.5%
26	Facial Dermatoses	19.5%
27	Hair Diseases	19.5%
28	Hand Dermatoses	19.5%
29	keratoacanthoma	19.5%
30	Nail Diseases	19.5%
31	Photosensitivity Disorders	19.5%
32	Prurigo	19.5%
33	Pyoderma	19.5%
34	Rosacea	19.5%
35	Sebaceous Gland Diseases	19.5%
36	Skin Diseases, Vesiculobullous	19.5%
37	Skin Ulcer	19.5%
38	Sweat Gland Diseases	19.5%
39	Skin Diseases, Papulosquamous	19.5%
40	Skin Diseases, Vascular	19.5%
41	Acneiform Eruptions	19.5%
42	Ocular Rosacea	19.5%
43	Subcorneal pustular dermatosis	19.5%
44	Erythematotelangiectatic Rosacea	19.5%
45	Papulopustular Rosacea	19.5%
46	Chronic Actinic Dermatitis	19.5%
47	Acne Vulgaris	19.4%
48	Contact Dermatitis	19.4%
49	Eczema	19.4%
50	Erythema Multiforme	19.4%
51	Intertrigo	19.4%
52	Neurodermatitis	19.4%
53	Rhinophyma	19.4%
54	Perioral Dermatitis	19.4%
55	Acne	19.4%
56	Dermatomyositis	18.3%
57	Foot Diseases	17.5%
58	Dermatitis Herpetiformis	17.4%
59	Sebaceous Gland Neoplasms	17.3%
60	Skin Diseases, Infectious	17.2%
61	Skin Neoplasms	17.2%
62	Pigmentation Disorders	17.2%
63	Necrobiosis Lipoidica Diabeticorum	17.2%
64	Lipomatosis	17.1%
65	Pruritus	17.1%
66	Erythema	17.1%
67	Necrolytic Migratory Erythema	17.1%
68	Cutaneous Fistula	17.1%
69	Nephrogenic Fibrosing Dermopathy	17.1%
70	Nephrogenic Systemic Fibrosis	17.1%
71	Panniculitis, Lupus Erythematosus	16.8%
72	Aicardi's syndrome	16.7%
73	Behcet Syndrome	16.7%
74	Erythema Induratum	16.5%
75	Cystic Fibrosis	16.4%
76	Dermatitis, Phototoxic	16%
77	Pityriasis Lichenoides et Varioliformis Acuta	16%
78	Pityriasis Lichenoides	16%
79	Phototoxicity	16%
80	Xeroderma	15.9%
81	Skin Abnormalities	15.8%
82	Foot Ulcer	15.7%
83	Cholesteatoma	15.6%
84	Parakeratosis	15.6%
85	Marfan Syndrome	15.3%
86	Mastocytosis	15.2%
87	Beckwith-Wiedemann Syndrome	15%
88	Wolf-Hirschhorn Syndrome	15%
89	Holoprosencephaly	14.6%
90	Dermatitis, Photoallergic	14.4%
91	Urticaria Pigmentosa	13.9%
92	Actinic keratosis	13.8%
93	CHARGE Syndrome	13.8%
94	Smith-Magenis syndrome	13.6%
95	Cri-du-Chat Syndrome	13.5%
96	Down Syndrome	13.5%
97	Trisomy 21	13.5%
98	Keratosis	13.2%
99	Variegate Porphyria	13%
100	Acute intermittent porphyria	13%
101	Porphyria Cutanea Tarda	13%
102	Lupus Erythematosus, Discoid	12.9%
103	Scleroderma, Limited	12.9%
104	Erythema Infectiosum	12.7%
105	Exanthema Subitum	12.7%
106	Erythema Nodosum	12.6%
107	Rubinstein-Taybi Syndrome	12.5%
108	Menkes Kinky Hair Syndrome	12.5%
109	Kartagener Syndrome	12.4%
110	Mobius Syndrome	12.4%
111	Connective Tissue Diseases	12.3%
112	Prader-Willi Syndrome	12.2%
113	Toxic Epidermal Necrolysis	12.1%
114	Stevens-Johnson Syndrome	12.1%
115	Dermatitis, Irritant	12%
116	Acne Conglobata	12%
117	Meconium Aspiration Syndrome	11.8%
118	Osteogenesis Imperfecta	11.8%
119	Cockayne Syndrome	11.5%
120	Ecthyma	11.5%
121	Abdominal Cramps	11.4%
122	Amniotic Band Syndrome	11.4%
123	Asphyxia Neonatorum	11.4%
124	Infant, Premature, Diseases	11.4%
125	Infantile Colic	11.4%
126	Angioedemas, Hereditary	11.3%
127	Tinea Capitis	11.1%
128	Onychomycosis	11.1%
129	Fetal Diseases	11.1%
130	Anhidrosis	11%
131	Pressure Ulcer	11%
132	Folliculitis	11%
133	Foot Dermatoses	11%
134	Gynecomastia	11%
135	Hypertrichosis	11%
136	Hypohidrosis	11%
137	Hypotrichosis	11%
138	Leg Ulcer	11%
139	Miliaria	11%
140	Parapsoriasis	11%
141	Pityriasis	11%
142	Psoriasis	11%
143	Sweet Syndrome	11%
144	Hidradenitis	11%
145	Onycholysis	11%
146	Miliaria Rubra	11%
147	Hyperpigmentation	11%
148	Lichenoid Eruptions	11%
149	Chloracne	11%
150	Dermatitis, Occupational	11%
151	Abnormalities, Drug-Induced	10.9%
152	Situs Inversus	10.9%
153	Alstrom Syndrome	10.9%
154	Fragile X Syndrome	10.8%
155	Dermatitis, Allergic Contact	10.7%
156	Granuloma Annulare	10.4%
157	Neoplastic Syndromes, Hereditary	10.2%
158	Anemia, Neonatal	10%
159	Multiple Epiphyseal Dysplasia	10%
160	Osteochondrodysplasias	10%
161	Pelger-Huet Anomaly	10%
162	Persistent Fetal Circulation Syndrome	10%
163	Werner Syndrome	10%
164	Myasthenic Syndromes, Congenital	10%
165	Umbilical hernia	9.9%
166	Eye Abnormalities	9.8%
167	Cardiovascular Abnormalities	9.8%
168	Acantholysis	9.8%
169	Breast Cyst	9.8%
170	Pemphigoid, Benign Mucous Membrane	9.8%
171	Pemphigus	9.8%
172	Piedra	9.8%
173	Sunburn	9.8%
174	Argyria	9.7%
175	Hirsutism	9.7%
176	Lactation Disorder	9.7%
177	Mastitis	9.7%
178	Urticaria	9.7%
179	Adiposis Dolorosa	9.7%
180	Pruritus Vulvae	9.7%
181	Erythema Chronicum Migrans	9.7%
182	Lymphatic Abnormalities	9.7%
183	Congenital Microtia	9.7%
184	Mastocytoma	9.6%
185	Pruritus Ani	9.6%
186	Congenital diaphragmatic hernia	9.5%
187	Anemia, Sickle Cell	9.4%
188	Thalassemia	9.4%
189	Muscular Dystrophy, Duchenne	9.4%
190	Dwarfism	9.1%
191	Hyperkeratosis, Epidermolytic	9.1%
192	Polycystic Kidney Diseases	9%
193	Williams Syndrome	9%
194	Neonatal Abstinence Syndrome	9%
195	Muscular Dystrophy	8.9%
196	Congenital nystagmus	8.9%
197	Toxoplasmosis, Congenital	8.8%
198	Hidradenitis Suppurativa	8.8%
199	Syphilis, Congenital	8.8%
200	Urogenital Abnormalities	8.8%
201	Smith-Lemli-Opitz Syndrome	8.7%
202	Dermatomycoses	8.7%
203	Mucocutaneous Lymph Node Syndrome	8.7%
204	Skin Diseases, Bacterial	8.7%
205	Mucopolysaccharidosis II	8.7%
206	Drug Eruptions	8.6%
207	Lipodystrophy	8.6%
208	Livedo Reticularis	8.6%
209	Malignant Atrophic Papulosis	8.6%
210	Polyarteritis Nodosa	8.6%
211	Takayasu Arteritis	8.6%
212	Deformity	8.5%
213	Retinal Dysplasia	8.4%
214	Noonan Syndrome	8.4%
215	Aniridia	8.4%
216	Diaper Rash	8.4%
217	Genetic Diseases, Inborn	8.3%
218	Kallmann Syndrome	8.2%
219	Autoimmune Lymphoproliferative Syndrome	8.1%
220	Congenital Hyperinsulinism	8%
221	Anencephaly	7.9%
222	Wiskott-Aldrich Syndrome	7.8%
223	Primary Ciliary Dyskinesia	7.8%
224	Tuberous Sclerosis	7.7%
225	Homocystinuria	7.6%
226	Mycetoma	7.4%
227	Tinea Pedis	7.4%
228	Peutz-Jeghers Syndrome	7.4%
229	Myotonic Dystrophy	7.2%
230	Maxillofacial Abnormalities	7.2%
231	Dural Arteriovenous Fistula	7.2%
232	Dextrocardia	7.1%
233	Refsum Disease	7%
234	Abnormalities, Radiation-Induced	7%
235	Lichen Planus	6.9%
236	Melanosis	6.9%
237	Chloasma	6.9%
238	Pityriasis Rosea	6.9%
239	Pityriasis Rubra Pilaris	6.9%
240	Vitiligo	6.9%
241	Lichen Nitidus	6.9%
242	Rett Syndrome	6.8%
243	Familial Mediterranean Fever	6.7%
244	Ophthalmia Neonatorum	6.6%
245	Zellweger Syndrome	6.6%
246	Adrenoleukodystrophy	6.6%
247	Collagen Diseases	6.5%
248	Mixed Connective Tissue Disease	6.5%
249	Mucinoses	6.5%
250	Laryngomalacia	6.5%
251	Pectus carinatum	6.4%
252	Hepatolenticular Degeneration	6.4%
253	Neuronal Ceroid-Lipofuscinoses	6.3%
254	Prune Belly Syndrome	6.2%
255	Twins, Conjoined	6.2%
256	Waardenburg Syndrome	6.2%
257	Ataxia Telangiectasia	6.2%
258	Alopecia	6.1%
259	Sweating, Gustatory	6.1%
260	Androgenetic Alopecia	6.1%
261	Auriculotemporal Syndrome	6.1%
262	Sickle Cell Trait	6.1%
263	Scimitar Syndrome	6.1%
264	Basal Cell Nevus Syndrome	6.1%
265	Lice Infestations	6%
266	Varicose Ulcer	6%
267	Breast Neoplasms, Male	6%
268	Triple Negative Breast Neoplasms	6%
269	Galactorrhea	6%
270	Giant Cell Arteritis	6%
271	Temporal Arteritis	6%
272	Amyloid Neuropathies, Familial	5.9%
273	Paralysis, Obstetric	5.9%
274	Retinopathy of Prematurity	5.9%
275	Classical Lissencephalies and Subcortical Band Heterotopias	5.9%
276	Amino Acid Metabolism, Inborn Errors	5.9%
277	Carbohydrate Metabolism, Inborn Errors	5.9%
278	Metal Metabolism, Inborn Errors	5.9%
279	Progeria	5.9%
280	Lysosomal Storage Diseases	5.9%
281	Cytochrome-c Oxidase Deficiency	5.9%
282	Peroxisomal Disorders	5.9%
283	Cartilage Diseases	5.8%
284	Rheumatism	5.8%
285	Chondromalacia	5.8%
286	Bronchopulmonary Dysplasia	5.8%
287	Polycystic Kidney, Autosomal Dominant	5.8%
288	Lupus Erythematosus, Systemic	5.7%
289	Overlap syndrome	5.7%
290	Turner Syndrome	5.7%
291	Fabry Disease	5.6%
292	Mucopolysaccharidosis III	5.5%
293	Anophthalmos	5.5%
294	Anus, Imperforate	5.5%
295	Hydranencephaly	5.5%
296	Microphthalmos	5.5%
297	Neural Tube Defects	5.5%
298	Tethered Cord Syndrome	5.5%
299	Iniencephaly	5.5%
300	Craniorachischisis	5.5%
301	Limb Deformities, Congenital	5.5%
302	Exencephaly	5.5%
303	Septo-Optic Dysplasia	5.5%
304	Craniofacial Abnormalities	5.5%
305	Cortical Dysplasia	5.5%
306	Malformations of Cortical Development	5.5%
307	Anorectal Malformations	5.5%
308	Bloom Syndrome	5.5%
309	Larva Migrans	5.4%
310	Leishmaniasis	5.4%
311	Molluscum Contagiosum	5.4%
312	Angioedema	5.4%
313	Onchocerciasis	5.4%
314	Chromoblastomycosis	5.4%
315	Dermatophytosis	5.4%
316	Sporotrichosis	5.4%
317	Tinea	5.4%
318	Tinea Versicolor	5.4%
319	Trichophytosis	5.4%
320	Hyalohyphomycosis	5.4%
321	CREST Syndrome	5.4%
322	Acute Generalized Exanthematous Pustulosis	5.3%
323	Respiratory Distress Syndrome, Newborn	5.3%
324	Charcot-Marie-Tooth Disease	5.3%
325	Fetal Growth Retardation	5.3%
326	Antley-Bixler Syndrome Phenotype	5.3%
327	Retinitis Pigmentosa	5.2%
328	Fetal Hypoxia	5.2%
329	Fetal Alcohol Spectrum Disorders	5.2%
330	Pigmentary retinopathy	5.2%
331	Chronic granulomatous disease	5.2%
332	Welander Distal Myopathy	5.2%
333	Acute Chest Syndrome	5.2%
334	Galactosemias	5.1%
335	Urea Cycle Disorders, Inborn	5.1%
336	Tyrosinemias	5.1%
337	Dupuytren Contracture	5%
338	Craniosynostosis	5%
339	Syndactyly	5%
340	Brachycephaly	5%
341	Canavan Disease	4.9%
342	Alexander Disease	4.9%
343	Blepharophimosis	4.9%
344	Laryngostenosis	4.9%
345	Mouth Abnormalities	4.9%
346	Warts	4.9%
347	Esophageal Atresia	4.9%
348	Intestinal Atresia	4.9%
349	Horseshoe Kidney	4.9%
350	Pectus excavatum	4.9%
351	Klippel-Feil Syndrome	4.9%
352	Gastroschisis	4.9%
353	Synostosis	4.9%
354	Lymphangiectasis, Intestinal	4.9%
355	Candidiasis, Chronic Mucocutaneous	4.8%
356	Cutaneous Candidiasis	4.8%
357	Erysipelas	4.8%
358	Serum Sickness	4.8%
359	Staphylococcal Skin Infections	4.8%
360	Erythrasma	4.8%
361	Carcinoma, Lobular	4.8%
362	Arthritis, Psoriatic	4.8%
363	Acanthosis Nigricans	4.8%
364	Alopecia Areata	4.8%
365	Lentigo	4.8%
366	Acrocephalosyndactylia	4.8%
367	Duane Retraction Syndrome	4.8%
368	Glycogen storage disease type II	4.8%
369	Chorioamnionitis	4.7%
370	Optic Atrophy, Hereditary, Leber	4.7%
371	Myotonia Congenita	4.7%
372	Thrombasthenia	4.7%
373	Antithrombin III Deficiency	4.7%
374	Protein C Deficiency	4.7%
375	Brain Diseases, Metabolic, Inborn	4.7%
376	Hyperphosphaturia	4.7%
377	Klinefelter Syndrome	4.7%
378	Afibrinogenemia	4.7%
379	Dystonia Musculorum Deformans	4.7%
380	Factor VII Deficiency	4.7%
381	Factor X Deficiency	4.7%
382	Factor XII Deficiency	4.7%
383	Hemophilia A	4.7%
384	Leukomalacia, Periventricular	4.7%
385	Activated Protein C Resistance	4.7%
386	Factor II deficiency	4.7%
387	Factor VIII Deficiency	4.7%
388	Factor V deficiency	4.7%
389	Factor XI Deficiency	4.7%
390	Hypoprothrombinemias	4.7%
391	Fanconi Anemia	4.7%
392	Nesidioblastosis	4.7%
393	Microcephaly	4.7%
394	Macrocephaly	4.7%
395	Lafora Disease	4.7%
396	Unverricht-Lundborg Syndrome	4.7%
397	Anemia, Diamond-Blackfan	4.7%
398	Cellulitis	4.6%
399	Arthrogryposis	4.5%
400	Choanal Atresia	4.5%
401	Tracheobronchomegaly	4.5%
402	Laryngocele	4.5%
403	Choledochal Cyst	4.4%
404	Hermaphroditism	4.4%
405	Disorders of Sex Development	4.4%
406	Cryptorchidism	4.4%
407	Hypospadias	4.4%
408	Central Nervous System Cysts	4.4%
409	Dandy-Walker Syndrome	4.4%
410	Multiple Endocrine Neoplasia	4.4%
411	POEMS Syndrome	4.4%
412	Bronchomalacia	4.4%
413	Tracheomalacia	4.4%
414	Congenital Hypothyroidism	4.3%
415	Lichen Planus, Oral	4.3%
416	Cleft Palate	4.1%
417	Leigh Disease	4.1%
418	Blastomycosis	4.1%
419	HIV-Associated Lipodystrophy Syndrome	4%
420	Bladder Exstrophy	4%
421	Epispadias	4%
422	Multicystic Dysplastic Kidney	4%
423	Kernicterus	4%
424	Jaw Abnormalities	4%
425	Hydrops Fetalis	3.9%
426	Porencephaly	3.8%
427	Alkaptonuria	3.8%
428	Glycogen Storage Disease	3.8%
429	Hypophosphatasia	3.8%
430	Propionic acidemia	3.8%
431	Dihydropyrimidine Dehydrogenase Deficiency	3.8%
432	Cystinosis	3.8%
433	Rhinoscleroma	3.8%
434	Leishmaniasis, Cutaneous	3.7%
435	Eczema Herpeticum	3.7%
436	Fusariosis	3.7%
437	Scleromyxedema	3.7%
438	Gaucher Disease	3.6%
439	Huntington Disease	3.6%
440	Poland Syndrome	3.5%
441	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.4%
442	Amelia	3.4%
443	Arachnodactyly	3.4%
444	Ectopia Cordis	3.4%
445	Ectromelia	3.4%
446	Hemimelia	3.4%
447	Meningomyelocele	3.4%
448	Phocomelia	3.4%
449	Sirenomelia	3.4%
450	Spina Bifida	3.4%
451	Polydactyly	3.4%
452	Brachydactyly	3.4%
453	Plagiocephaly	3.4%
454	Lower Extremity Deformities, Congenital	3.4%
455	Upper Extremity Deformities, Congenital	3.4%
456	Single umbilical artery	3.4%
457	Hyaline Membrane Disease	3.4%
458	Epidermodysplasia Verruciformis	3.4%
459	Herpes Labialis	3.4%
460	Hypolipoproteinemias	3.4%
461	Hyperlipidemia, Familial Combined	3.4%
462	Hyperlipoproteinemia Type III	3.4%
463	Diabetic Foot	3.4%
464	Nephroblastoma	3.4%
465	Staphylococcal Scalded Skin Syndrome	3.4%
466	Mesenteric Panniculitis	3.3%
467	Panniculitis, Peritoneal	3.3%
468	Tietze's Syndrome	3.3%
469	Orbital Cellulitis	3.3%
470	Myxoid cyst	3.3%
471	Myxedema	3.2%
472	Adenomatous Polyposis Coli	3.1%
473	Familial Periodic Paralysis	3.1%
474	Condylomata Acuminata	3.1%
475	Furunculosis	3.1%
476	furuncle	3.1%
477	Lactose Intolerance	3.1%
478	Impetigo	3.1%
479	Hyperhomocysteinemia	3.1%
480	Aortic coarctation	3.1%
481	Cor Triatriatum	3.1%
482	Coronary Vessel Anomalies	3.1%
483	Dental Enamel Hypoplasia	3.1%
484	Patent ductus arteriosus	3.1%
485	Ebstein Anomaly	3.1%
486	Heart Septal Defects	3.1%
487	Hypodontia	3.1%
488	Macrostomia	3.1%
489	Meningocele	3.1%
490	Microstomia	3.1%
491	Tetralogy of Fallot	3.1%
492	Transposition of Great Vessels	3.1%
493	Hypoplastic Left Heart Syndrome	3.1%
494	May-Thurner Syndrome	3.1%
495	Encephalocele	3.1%
496	Renal Aminoacidurias	3%
497	Fanconi Syndrome	3%
498	Pseudohypoaldosteronism	3%
499	Liddle Syndrome	3%
500	Craniofacial Dysostosis	3%
501	Tay-Sachs Disease	3%
502	Niemann-Pick Disease, Type C	3%
503	Hyperlipoproteinemia Type IV	3%
504	Hyperlipoproteinemia Type V	3%
505	Wolff-Parkinson-White Syndrome	3%
506	Hereditary Angioedema Type III	2.9%
507	Hereditary Angioedema Types I and II	2.9%
508	Osteochondritis	2.9%
509	Polymyalgia Rheumatica	2.9%
510	Micrognathism	2.9%
511	Pierre Robin Syndrome	2.9%
512	Keloid	2.9%
513	Gout	2.8%
514	Multiple Endocrine Neoplasia Type 1	2.8%
515	Pseudohypoparathyroidism	2.8%
516	Glycogen Storage Disease Type I	2.8%
517	Glycogen Storage Disease Type V	2.8%
518	Friedreich Ataxia	2.8%
519	Renal tubular acidosis	2.8%
520	Long QT Syndrome	2.8%
521	Platybasia	2.8%
522	Tricuspid Atresia	2.8%
523	Arrhythmogenic Right Ventricular Dysplasia	2.8%
524	Denys-Drash Syndrome	2.8%
525	Gonadal Dysgenesis	2.7%
526	Adrenogenital Syndrome	2.7%
527	Ovotesticular Disorders of Sex Development	2.7%
528	Hyperandrogenism	2.7%
529	Retrognathia	2.7%
530	Rheumatoid Arthritis	2.6%
531	Juvenile arthritis	2.6%
532	carbuncle	2.6%
533	Lupus Nephritis	2.6%
534	Hypoalphalipoproteinemias	2.5%
535	Prognathism	2.5%
536	Familial Hypophosphatemic Rickets	2.5%
537	Dermal Sinus	2.4%
538	Spina Bifida Cystica	2.4%
539	Spina Bifida Occulta	2.4%
540	Lissencephaly	2.4%
541	Polymicrogyria	2.4%
542	Pachygyria	2.4%
543	Schizencephaly	2.4%
544	Periventricular Nodular Heterotopia	2.4%
545	Glycosuria, Renal	2.3%
546	Hypokalemic periodic paralysis	2.2%
547	Cystinuria	2.2%
548	Aortopulmonary Septal Defect	2.1%
549	Double Outlet Right Ventricle	2.1%
550	Endocardial Cushion Defects	2.1%
551	Myocardial bridging	2.1%
552	Aorticopulmonary Septal Defect	2.1%
553	Arthritis, Gouty	2%
554	MELAS Syndrome	2%
555	Mandibulofacial Dysostosis	1.9%
556	Romano-Ward Syndrome	1.9%
557	Rheumatoid Nodule	1.8%
558	Truncus Arteriosus, Persistent	1.7%
559	Goldenhar Syndrome	1.7%
560	Felty Syndrome	1.6%
561	Arteriovenous fistula	1.6%
562	Talipes	1.5%
563	Lupus Vasculitis, Central Nervous System	1.5%
564	Rheumatoid Vasculitis	1.5%
565	Sicca Syndrome	1.3%
566	Sjogren's Syndrome	1.3%
567	Congenital clubfoot	1.3%
568	Vertical Talus	1.3%

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