MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Diabetic Cardiomyopathies

(UMLS:C0853897)

Definition:: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
UMLS ID:: C0853897
MeSH ID:: D058065

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.238.235

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.246.099.625

Synonym(s)

Diabetic Cardiomyopathies

Cardiomyopathy due to diabetes mellitus

Diabetic cardiomyopathy

cardiomyopathy diabetic

diabetic cardiomyopathy

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,2-diacylglycerol	3044883	CTD
2	3,3',4,5'-tetrahydroxystilbene	31323227	CTD
3	Acetylcysteine	19561140	CTD
4	Alloxan	22138235	CTD
5	Copper	24927960	CTD
6	Enalapril	21416479	CTD
7	Metoprolol	18203848 18703049	CTD
8	Niacinamide	23677724	CTD
9	Nifedipine	7564366	CTD
10	Pyruvaldehyde	20621070	CTD
11	Resveratrol	View details 19561140 20828608 24889822 25050809	CTD
12	Rosiglitazone	19902320	CTD
13	Streptozocin	View details 3044883 6225876 6708725 7564366 11375343 15587404 15645163 16025228 16045816 16129698 16685413 16980342 17909696 18203848 18332268 18703049 18945756 19561140 19951573 19957251 20828608 21136691 21416479 22429817 23677724 24889822 24927960 25050809 28178614 28700904 31323227	CTD
14	Taurine	16025228 22138235	CTD
15	Thioctic Acid	19951573	CTD
16	Trientine	21136691 23202417 24927960	CTD
17	UCF 101	19561140	CTD
18	fasudil	22429817	CTD
19	geraniol	28178614	CTD
20	turmeric extract	28700904	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Cardiomyopathy, Dilated	33.3%
2	Restrictive cardiomyopathy	31.1%
3	Endocardial Fibroelastosis	31.1%
4	Myocarditis	31.1%
5	Endomyocardial Fibrosis	31.1%
6	Carditis	31.1%
7	Hypertrophic Cardiomyopathy	29.2%
8	Hypertrophic obstructive cardiomyopathy	29.2%
9	Diabetic Angiopathies	28.8%
10	Diabetic Foot	25.1%
11	Arrhythmogenic Right Ventricular Dysplasia	24.3%
12	Diabetic Neuropathies	23.3%
13	Diabetic Amyotrophy	23.3%
14	Diabetic Autonomic Neuropathy	23.3%
15	Cardiomyopathy, Alcoholic	23.1%
16	Hyperglycemic Hyperosmolar Nonketotic Coma	23.1%
17	Chagas Cardiomyopathy	23%
18	Myocardial Reperfusion Injury	22.7%
19	Myocardial Ischemia	20.7%
20	Cardiac Tamponade	20.5%
21	Endocarditis	20.5%
22	Cardiac Arrest	20.5%
23	Heart failure	20.5%
24	Pericardial effusion	20.5%
25	Pericarditis	20.5%
26	Pneumopericardium	20.5%
27	Cor pulmonale	20.5%
28	Ventricular Outflow Obstruction	20.5%
29	Ventricular Dysfunction	20.5%
30	Pleuropericarditis	20.5%
31	Aortic Valve Stenosis	20%
32	Pulmonary Valve Stenosis	20%
33	Diabetic Nephropathy	18.5%
34	Diabetic Ketoacidosis	18.4%
35	Diabetic Retinopathy	16.8%
36	Heart Block	16%
37	Tachycardia	16%
38	Tachyarrhythmia	16%
39	Cardiac Output, High	15.5%
40	Myocardial Stunning	15.5%
41	Low Cardiac Output Syndrome	15.5%
42	Tricuspid Atresia	15.5%
43	Cardiomegaly	15.3%
44	Postpericardiotomy Syndrome	15.3%
45	Cardiac Hypertrophy	15.3%
46	Rheumatic Heart Disease	15.1%
47	Supravalvular aortic stenosis	14.8%
48	Lown-Ganong-Levine Syndrome	14.8%
49	Aortic Valve Insufficiency	13.3%
50	Coronary heart disease	13.3%
51	Heart Rupture, Post-Infarction	13.3%
52	Mitral Valve Insufficiency	13.3%
53	Mitral Valve Stenosis	13.3%
54	Myocardial Infarction	13.3%
55	Pericarditis, Constrictive	13.3%
56	Pulmonary Valve Insufficiency	13.3%
57	Tricuspid Valve Insufficiency	13.3%
58	Tricuspid Valve Stenosis	13.3%
59	Ventricular Dysfunction, Left	13.3%
60	Right Ventricular Dysfunction	13.3%
61	Acute Coronary Syndrome	13.3%
62	Heart Failure, Systolic	13.3%
63	Heart Failure, Diastolic	13.3%
64	Long QT Syndrome	13.3%
65	Sick Sinus Syndrome	12.6%
66	Gestational Diabetes	12.2%
67	Latent Autoimmune Diabetes in Adults	12.2%
68	Diabetes Mellitus, Experimental	12.1%
69	Adrenal Gland Diseases	11.9%
70	Gonadal Disorders	11.9%
71	Parathyroid Diseases	11.9%
72	Thyroid Diseases	11.9%
73	Vascular Diseases	11.9%
74	Adams-Stokes Syndrome	11.8%
75	Atrioventricular Block	11.8%
76	Bundle-Branch Block	11.8%
77	Atrial Premature Complexes	11.8%
78	Sinoatrial Block	11.8%
79	Tachycardia, Paroxysmal	11.8%
80	Supraventricular tachycardia	11.8%
81	Tachycardia, Ventricular	11.8%
82	Wolff-Parkinson-White Syndrome	11.8%
83	Tachycardia, Reciprocating	11.8%
84	Kounis Syndrome	10.8%
85	Aortic coarctation	10.6%
86	Cor Triatriatum	10.6%
87	Coronary Vessel Anomalies	10.6%
88	Patent ductus arteriosus	10.6%
89	Ebstein Anomaly	10.6%
90	Heart Septal Defects	10.6%
91	Tetralogy of Fallot	10.6%
92	Transposition of Great Vessels	10.6%
93	Hypoplastic Left Heart Syndrome	10.6%
94	Angina Pectoris	10.6%
95	Coronary Aneurysm	10.5%
96	Bacterial Endocarditis	10.2%
97	Sinus Arrhythmia	10%
98	Atrial Fibrillation	10%
99	Atrial Flutter	10%
100	Edema, Cardiac	10%
101	Ventricular Fibrillation	10%
102	Ventricular Flutter	10%
103	Parasystole	10%
104	Paroxysmal atrial fibrillation	10%
105	Bradycardia	10%
106	Sudden Cardiac Death	9.9%
107	Left Ventricular Hypertrophy	9.9%
108	Right Ventricular Hypertrophy	9.9%
109	Aortic Valve Prolapse	9.9%
110	Tricuspid Valve Prolapse	9.9%
111	Takotsubo Cardiomyopathy	9.9%
112	Coronary Occlusion	9.8%
113	Microvascular Angina	9.8%
114	Coronary Stenosis	9.8%
115	ST segment elevation myocardial infarction	9.8%
116	Coronary Thrombosis	9.8%
117	Coronary Artery Disease	9.8%
118	Carcinoid Heart Disease	9.8%
119	Romano-Ward Syndrome	9.8%
120	Tachycardia, Atrioventricular Nodal Reentry	9.7%
121	Tachycardia, Ectopic Atrial	9.7%
122	Tachycardia, Ectopic Junctional	9.7%
123	Sinus Tachycardia	9.7%
124	Torsades de Pointes	9.7%
125	Accelerated Idioventricular Rhythm	9.7%
126	Bone Diseases, Endocrine	8.9%
127	Endocrine Gland Neoplasms	8.9%
128	Pregnancy Complications, Cardiovascular	8.9%
129	Cardiovascular Abnormalities	8.9%
130	Dextrocardia	8.8%
131	Pituitary Diseases	8.7%
132	Adrenal Gland Neoplasms	8.2%
133	Coronary Restenosis	8.1%
134	Dyspnea, Paroxysmal	7.9%
135	Shock, Cardiogenic	7.9%
136	Aortopulmonary Septal Defect	7.8%
137	Double Outlet Right Ventricle	7.8%
138	Endocardial Cushion Defects	7.8%
139	Myocardial bridging	7.8%
140	Aorticopulmonary Septal Defect	7.8%
141	Angina, Unstable	7.8%
142	Kearns-Sayre syndrome	7.5%
143	Sinus Arrest, Cardiac	7.4%
144	Dwarfism	7%
145	Adrenal Cortex Diseases	6.8%
146	Aneurysm	6.8%
147	Angiomatosis	6.8%
148	Aortic Diseases	6.8%
149	Arterial Occlusive Diseases	6.8%
150	Euthyroid Sick Syndromes	6.8%
151	Goiter	6.8%
152	Hyperemia	6.8%
153	Hyperparathyroidism	6.8%
154	Hyperthyroidism	6.8%
155	Hyperthyroxinemia	6.8%
156	Hypogonadism	6.8%
157	Hypoparathyroidism	6.8%
158	Hypotension	6.8%
159	Hypothyroidism	6.8%
160	Parathyroid Neoplasms	6.8%
161	Delayed Puberty	6.8%
162	Precocious Puberty	6.8%
163	Superior Vena Cava Syndrome	6.8%
164	Telangiectasis	6.8%
165	Thyroid Neoplasm	6.8%
166	Thyroiditis	6.8%
167	Vasculitis	6.8%
168	Venous Insufficiency	6.8%
169	Peripheral Vascular Diseases	6.8%
170	Embolism and Thrombosis	6.8%
171	Angiodysplasia	6.8%
172	Hypogonadotropic hypogonadism	6.8%
173	Capillary Leak Syndrome	6.8%
174	Thyroid carcinoma	6.8%
175	Testotoxicosis	6.8%
176	Prehypertension	6.8%
177	Secondary hypothyroidism	6.8%
178	Primary Hyperthyroidism	6.8%
179	Primary Hypothyroidism	6.8%
180	Aortic Aneurysm	6.7%
181	Aortitis	6.7%
182	Leriche Syndrome	6.7%
183	Noonan Syndrome	6.7%
184	Periphlebitis	6.7%
185	Phlebitis	6.7%
186	Thromboangiitis Obliterans	6.7%
187	Truncus Arteriosus, Persistent	6.5%
188	Angina Pectoris, Variant	6.5%
189	Subacute Bacterial Endocarditis	6.1%
190	Embolism, Amniotic Fluid	6%
191	Marfan Syndrome	6%
192	Postphlebitic Syndrome	5.8%
193	Retinal Vein Occlusion	5.8%
194	Arteriovenous fistula	5.7%
195	Thrombophlebitis	5.5%
196	Vascular System Injuries	5.4%
197	Malignant Atrophic Papulosis	5.3%
198	Shwartzman Phenomenon	5.3%
199	May-Thurner Syndrome	5.3%
200	Compartment syndromes	5.2%
201	Hepatic Veno-Occlusive Disease	5.2%
202	Peliosis Hepatis	5.2%
203	Testicular Diseases	5.2%
204	Varicocele	5.2%
205	Blue Toe Syndrome	5.1%
206	Cerebrovascular Disorders	5.1%
207	Reperfusion Injury	5.1%
208	Splenic Infarction	5.1%
209	Cerebrovascular Insufficiency	5.1%
210	Vascular Neoplasms	5.1%
211	Spinal Cord Vascular Diseases	5.1%
212	Vasoplegia	5.1%
213	Hemorrhoids	5%
214	Ovarian Diseases	5%
215	Thoracic Outlet Syndrome	5%
216	Empty Sella Syndrome	5%
217	Hyperpituitarism	5%
218	Hypopituitarism	5%
219	Hypophysitis	5%
220	Aortic Rupture	5%
221	Pituitary Apoplexy	4.9%
222	Aortic Aneurysm, Abdominal	4.9%
223	Aortic Aneurysm, Thoracic	4.9%
224	Congenital Hypothyroidism	4.8%
225	ovarian neoplasm	4.8%
226	Turner Syndrome	4.7%
227	Intracranial Embolism and Thrombosis	4.6%
228	Carotid Artery Thrombosis	4.6%
229	Carotid Stenosis	4.6%
230	Intracranial Aneurysm	4.6%
231	Graves Disease	4.5%
232	Aneurysm, Dissecting	4.4%
233	Arteriosclerosis	4.4%
234	Arteritis	4.4%
235	Cushing Syndrome	4.4%
236	Embolism	4.4%
237	Erythromelalgia	4.4%
238	Fibromuscular Dysplasia	4.4%
239	Hyperaldosteronism	4.4%
240	Hyperparathyroidism, Secondary	4.4%
241	Malignant Hypertension	4.4%
242	Hypoaldosteronism	4.4%
243	Raynaud Disease	4.4%
244	Thromboembolism	4.4%
245	Thrombosis	4.4%
246	Thyrotoxicosis	4.4%
247	Essential Hypertension	4.4%
248	Aneurysm, Ruptured	4.4%
249	Iliac Aneurysm	4.4%
250	Hyperparathyroidism, Primary	4.4%
251	Pulmonary artery stenosis	4.4%
252	White Coat Hypertension	4.4%
253	Systemic Vasculitis	4.4%
254	Embolus	4.4%
255	Thyroid Hormone Resistance Syndrome	4.4%
256	Moyamoya Disease	4.4%
257	Thyroid Nodule	4.4%
258	Scimitar Syndrome	4.3%
259	Hand-Arm Vibration Syndrome	4.2%
260	Testicular Neoplasms	4.2%
261	Adrenocortical carcinoma	4.2%
262	Optic Neuropathy, Ischemic	4.1%
263	Williams Syndrome	4.1%
264	Anterior Ischemic Optic Neuropathy	4.1%
265	Mesenteric vascular insufficiency	4.1%
266	Diabetes Insipidus	4%
267	Angioedema	4%
268	Colitis, Ischemic	4%
269	Polyarteritis Nodosa	3.9%
270	Takayasu Arteritis	3.9%
271	Pituitary Adenoma	3.9%
272	Pituitary Neoplasms	3.9%
273	Intracranial Arteriosclerosis	3.9%
274	Cerebral Atherosclerosis	3.9%
275	Cerebral Arteriosclerosis	3.9%
276	Vasculitis, Central Nervous System	3.8%
277	Prolactinoma	3.7%
278	Growth Hormone-Secreting Pituitary Adenoma	3.7%
279	Cerebral Thrombosis	3.6%
280	Intracranial Embolism	3.6%
281	Intracranial Thrombosis	3.6%
282	Hermaphroditism	3.4%
283	Disorders of Sex Development	3.4%
284	Addison Disease	3.4%
285	Retinal Artery Occlusion	3.4%
286	Retinal Vasculitis	3.4%
287	Hypertensive Retinopathy	3.4%
288	Autoimmune thyroiditis	3.4%
289	Primary Adrenal Insufficiency	3.4%
290	Anterior Compartment Syndrome	3.3%
291	Myxedema	3.3%
292	Orchitis	3.3%
293	Vasculitis, Leukocytoclastic, Cutaneous	3.3%
294	Gastric Antral Vascular Ectasia	3.3%
295	Abdominal Compartment Syndrome	3.3%
296	Carotid Artery Diseases	3.3%
297	Brain Ischemia	3.3%
298	Ectopia Cordis	3.3%
299	Hypotension, Orthostatic	3.3%
300	Cerebrovascular accident	3.3%
301	Varicose Ulcer	3.3%
302	Vasospasm, Intracranial	3.3%
303	Spinal Cord Ischemia	3.3%
304	Intracranial Arterial Diseases	3.3%
305	Primary Graft Dysfunction	3.3%
306	Single umbilical artery	3.3%
307	Post-Exercise Hypotension	3.3%
308	Arteriosclerosis Obliterans	3.3%
309	Atherosclerosis	3.3%
310	Air Embolism	3.3%
311	Endarteritis	3.3%
312	Venous Thrombosis	3.3%
313	Deep Vein Thrombosis	3.3%
314	Hashimoto Disease	3.3%
315	Venous Thromboembolism	3.3%
316	Ovarian Hyperstimulation Syndrome	3.3%
317	Hyperprolactinemia	3.3%
318	Giant Cell Arteritis	3.3%
319	Temporal Arteritis	3.3%
320	Brain Infarction	3.2%
321	Nelson Syndrome	3.2%
322	Sinus Thrombosis, Intracranial	3.1%
323	Lemierre Syndrome	3%
324	Multiple Endocrine Neoplasia	2.9%
325	Pancreatic Neoplasm	2.9%
326	Kallmann Syndrome	2.9%
327	Kartagener Syndrome	2.9%
328	Subarachnoid Hemorrhage, Traumatic	2.9%
329	Carotid Artery, Internal, Dissection	2.9%
330	CREST Syndrome	2.9%
331	granulosa cell tumor	2.8%
332	Carcinoma, Ovarian Epithelial	2.8%
333	Cavernous Sinus Thrombosis	2.8%
334	Sagittal Sinus Thrombosis	2.8%
335	Vertebral Artery Dissection	2.8%
336	Infarction, Middle Cerebral Artery	2.8%
337	Infarction, Anterior Cerebral Artery	2.8%
338	Infarction, Posterior Cerebral Artery	2.8%
339	Mesenteric Vascular Occlusion	2.7%
340	Mucocutaneous Lymph Node Syndrome	2.7%
341	Sturge-Weber Syndrome	2.7%
342	Cerebral Infarction	2.7%
343	Brain Stem Infarctions	2.7%
344	Corpus Luteum Cyst	2.7%
345	Ovarian Cysts	2.7%
346	Gigantism	2.7%
347	Livedo Reticularis	2.7%
348	Renal hypertension	2.6%
349	Renal Artery Obstruction	2.6%
350	Renal Artery Stenosis	2.6%
351	Acromegaly	2.6%
352	Hemangioma, Cavernous	2.6%
353	Basal Ganglia Cerebrovascular Disease	2.6%
354	Anovulation	2.6%
355	Vascular Headaches	2.6%
356	Scurvy	2.6%
357	Oophoritis	2.6%
358	Intermittent Claudication	2.5%
359	Pulmonary Embolism	2.5%
360	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2.5%
361	Klinefelter Syndrome	2.5%
362	No-Reflow Phenomenon	2.5%
363	Cerebral Arterial Diseases	2.4%
364	Vertebrobasilar Insufficiency	2.4%
365	Carotid Artery Injuries	2.4%
366	Anterior Spinal Artery Syndrome	2.4%
367	Basilar Artery Stenosis	2.4%
368	Vertebral Artery Stenosis	2.4%
369	Intracranial Hemorrhage, Hypertensive	2.4%
370	Transient Cerebral Ischemia	2.4%
371	Lateral Medullary Syndrome	2.4%
372	Cryptorchidism	2.2%
373	Dural Arteriovenous Fistula	2.2%
374	Ischemic contracture	2.2%
375	Basal Ganglia Hemorrhage	2.2%
376	Angioedemas, Hereditary	2.2%
377	Cryoglobulinemia	2.2%
378	Gonadal Dysgenesis	2.2%
379	Leukomalacia, Periventricular	2.2%
380	Adrenogenital Syndrome	2.2%
381	Ovotesticular Disorders of Sex Development	2.2%
382	Hepatic Vein Thrombosis	2.1%
383	Budd-Chiari Syndrome	2.1%
384	Pulmonary Infarction	2.1%
385	Subclavian Steal Syndrome	2%
386	Polycystic Ovary Syndrome	2%
387	Leydig Cell Tumor	2%
388	Hypertension, Renovascular	2%
389	Subarachnoid Hemorrhage	2%
390	Hypoxia-Ischemia, Brain	2%
391	Cerebral Hemorrhage	2%
392	Hereditary Angioedema Type III	1.9%
393	Hereditary Angioedema Types I and II	1.9%
394	Hyperandrogenism	1.9%
395	Putaminal Hemorrhage	1.9%
396	Multiple Endocrine Neoplasia Type 1	1.9%
397	Shy-Drager Syndrome	1.9%
398	Purpura, Hyperglobulinemic	1.9%
399	Dementia, Vascular	1.8%
400	Behcet Syndrome	1.7%
401	Waldenstrom Macroglobulinemia	1.7%
402	Multiple Myeloma	1.7%
403	Granulomatosis with polyangiitis	1.7%
404	Cerebral Amyloid Angiopathy	1.6%
405	Lupus Vasculitis, Central Nervous System	1.5%
406	Ataxia Telangiectasia	1.5%
407	Pseudoxanthoma Elasticum	1.5%
408	Carcinoma, Pancreatic Ductal	1.5%
409	Rheumatoid Vasculitis	1.4%
410	insulinoma	1.2%
411	Gastrinoma	1.2%
412	Glucagonoma	1.2%
413	Carcinoma, Endometrioid	1.2%
414	Waterhouse-Friderichsen Syndrome	1.2%
415	Renal Osteodystrophy	1.1%
416	Renal rickets	1.1%
417	Vipoma	1.1%
418	Hematoma, Subdural	1%
419	Hematoma, Epidural, Cranial	1%
420	Hematoma, Subdural, Intracranial	0.9%
421	Hematoma, Subdural, Chronic	0.9%
422	Hematoma, Subdural, Acute	0.9%
423	Brain Hemorrhage, Traumatic	0.9%
424	MELAS Syndrome	0.9%
425	Adrenoleukodystrophy	0.7%
426	Denys-Drash Syndrome	0.7%
427	Fabry Disease	0.7%

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