MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Spondylosis

(UMLS:C0038019)

Definition:: A degenerative spinal disease that can involve any part of the VERTEBRA, the INTERVERTEBRAL DISK, and the surrounding soft tissue.
UMLS ID:: C0038019
MeSH ID:: D055009

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.900.938

Synonym(s)

Spondylosis

SPONDYLOSIS

Spondylosis, NOS

Spondylosis, unspecified

spondyloses

spondylosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	rofecoxib	FAERS: 13		OFFSIDES US FAERS
2	Atorvastatin	FAERS: 1		US FAERS
3	Bupivacaine	FAERS: 1		US FAERS
4	Naproxen	FAERS: 1		US FAERS
5	Tacrolimus	FAERS: 1		US FAERS
6	frovatriptan	FAERS: 1		US FAERS
7	Acetaminophen		4712825	CTD
8	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination			OFFSIDES
9	Bisacodyl			OFFSIDES
10	Bupropion			OFFSIDES
11	Calcium Carbonate			OFFSIDES
12	Carbamazepine			OFFSIDES
13	Carnitine			OFFSIDES
14	Chlorpheniramine		4712825	CTD
15	Cisapride			OFFSIDES
16	Dextropropoxyphene		4712825	CTD
17	Digoxin			OFFSIDES
18	Estrogens, Conjugated (USP)			OFFSIDES
19	Etodolac			OFFSIDES
20	Leuprolide			SIDER
21	Loratadine			OFFSIDES
22	Methocarbamol			OFFSIDES
23	Misoprostol			OFFSIDES
24	Nabumetone			OFFSIDES
25	Nisoldipine			OFFSIDES
26	Nitrofurantoin			OFFSIDES
27	Nortriptyline			OFFSIDES
28	Orlistat			OFFSIDES
29	Pentazocine		4712825	CTD
30	Phentermine			OFFSIDES
31	Piroxicam			OFFSIDES
32	Ubiquinone			OFFSIDES
33	acetaminophen, dextropropoxyphene, drug combination			OFFSIDES
34	cyclobenzaprine			OFFSIDES
35	flunisolide			OFFSIDES
36	geranylgeranylacetone			OFFSIDES
37	moexipril			OFFSIDES
38	sibutramine			OFFSIDES
39	telmisartan, hydrochlorothiazide drug combination			OFFSIDES
40	tizanidine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Spinal Stenosis	46.7%
2	Intervertebral Disc Degeneration	46.7%
3	Lordosis	34.4%
4	kyphosis	34.4%
5	Spinal Neoplasms	33.3%
6	Spondylitis	33.3%
7	Bone Diseases, Developmental	31%
8	Hyperostosis	31%
9	Osteitis	31%
10	Osteitis Deformans	31%
11	Osteochondrosis	31%
12	Platybasia	29.1%
13	Osteoarthropathy, Secondary Hypertrophic	27.9%
14	Discitis	24.4%
15	Spondylarthropathies	22.2%
16	Bone Diseases, Endocrine	22%
17	Bone Diseases, Infectious	20.9%
18	Bone neoplasms	20.9%
19	Osteopenia	20.9%
20	Osteochondritis	20.7%
21	Bone Resorption	20.5%
22	Aseptic Necrosis of Bone	20.5%
23	Ainhum	20%
24	Dysostoses	20%
25	Gigantism	20%
26	Tuberculosis, Spinal	19.4%
27	Fasciitis	18.5%
28	Foot Deformities	18.5%
29	Arthropathy	18.5%
30	Ankylosing spondylitis	18.1%
31	Osteoarthritis, Spine	17.9%
32	Pectus excavatum	15.3%
33	Chondrodysplasia Punctata	14.8%
34	Enchondromatosis	14.8%
35	Osteosclerosis	14.8%
36	Kashin-Beck Disease	14.8%
37	Arthritis, Psoriatic	14.4%
38	Contracture	14%
39	Fasciitis, Plantar	14%
40	Arthritis, Reactive	13.8%
41	Multiple Epiphyseal Dysplasia	13.6%
42	Osteochondrodysplasias	13.6%
43	Pectus carinatum	13.6%
44	Osteomyelitis	13.3%
45	Osteoporosis	13.3%
46	Periostitis	13.3%
47	Bone Demineralization, Pathologic	13.3%
48	Post-Traumatic Osteoporosis	13.3%
49	Alveolar Bone Loss	13.2%
50	Femur Head Necrosis	13.2%
51	Osteolysis	13.2%
52	Jaw Diseases	12.8%
53	Klippel-Feil Syndrome	12.6%
54	Synostosis	12.6%
55	Arthrogryposis	12.5%
56	Cartilage Diseases	12.2%
57	Foot Diseases	12.2%
58	Melorheostosis	12.2%
59	Myopathy	12.2%
60	Osteopetrosis	12.2%
61	Rheumatism	12.2%
62	Chondromalacia	12.2%
63	Congenital Hypothyroidism	11.7%
64	Dwarfism	10.7%
65	Craniofacial Dysostosis	10.7%
66	Arthritis	10.3%
67	Bursitis	10.3%
68	Fibromyalgia	10.3%
69	Joint Instability	10.3%
70	Myofascial Pain Syndromes	10.3%
71	Polymyalgia Rheumatica	10.3%
72	Rhabdomyolysis	10.3%
73	Synovitis	10.3%
74	Joint laxity	10.3%
75	Polyarthritis	10.3%
76	Frozen shoulder	10.3%
77	Patellofemoral Pain Syndrome	10.3%
78	Metatarsalgia	10.3%
79	Eosinophilic Granuloma	9.9%
80	Acromegaly	9.9%
81	Joint Tuberculosis	9.9%
82	Tuberculosis, Osteoarticular	9.9%
83	Bone Tuberculosis	9.9%
84	Osteoporosis, Postmenopausal	9.8%
85	Hip Contracture	8.9%
86	Periarthritis	8.9%
87	Craniosynostosis	8.4%
88	Syndactyly	8.4%
89	Brachycephaly	8.4%
90	Rheumatic Fever	8.4%
91	Ischemic contracture	8%
92	Rickets	7.9%
93	Gout	7.8%
94	Osteoarthritis, Knee	7.7%
95	Osteogenesis Imperfecta	7.6%
96	Temporomandibular Joint Disorders	7.5%
97	Acrocephalosyndactylia	7.4%
98	Goldenhar Syndrome	7.4%
99	Mastoiditis	7.3%
100	Petrositis	7.3%
101	Compartment syndromes	7%
102	Maxillary Diseases	7%
103	Tendinitis	7%
104	Tendinopathy	7%
105	Talipes	6.9%
106	Rheumatoid Arthritis	6.8%
107	Juvenile arthritis	6.8%
108	Poland Syndrome	6.8%
109	Hemarthrosis	6.8%
110	Myositis	6.8%
111	Tietze's Syndrome	6.8%
112	Limb Deformities, Congenital	6.8%
113	Isaacs syndrome	6.8%
114	Mandibulofacial Dysostosis	6.8%
115	Craniofacial Abnormalities	6.8%
116	Myotonic Disorders	6.8%
117	Bunion	6.7%
118	Fibrodysplasia Ossificans Progressiva	6.7%
119	Myoglobinuria	6.7%
120	Myositis Ossificans	6.7%
121	Tenosynovitis	6.7%
122	Sacroiliitis	6.7%
123	Pseudohypoparathyroidism	6.6%
124	Temporomandibular Joint Dysfunction Syndrome	6.4%
125	Antley-Bixler Syndrome Phenotype	6.2%
126	Osteomalacia	5.8%
127	Rheumatoid Nodule	5.7%
128	Arthritis, Gouty	5.4%
129	Palatal Neoplasms	5.4%
130	Rubinstein-Taybi Syndrome	5.3%
131	Congenital clubfoot	5.3%
132	Vertical Talus	5.3%
133	Medial Tibial Stress Syndrome	5.2%
134	Mitochondrial Myopathies	5.1%
135	Marfan Syndrome	5.1%
136	Muscle Cramp	5%
137	Eosinophilia-Myalgia Syndrome	5%
138	Gastroschisis	5%
139	Muscle Rigidity	5%
140	Muscle Spasticity	5%
141	Cogwheel Rigidity	5%
142	Nuchal Rigidity	5%
143	Basal Cell Nevus Syndrome	4.9%
144	Felty Syndrome	4.6%
145	Arthritis, Infectious	4.5%
146	Anterior Compartment Syndrome	4.4%
147	Enthesopathy	4.4%
148	Arthritis, Experimental	4.4%
149	Abdominal Compartment Syndrome	4.4%
150	Amelia	4.4%
151	Arachnodactyly	4.4%
152	Ectromelia	4.4%
153	Hemimelia	4.4%
154	Phocomelia	4.4%
155	Sirenomelia	4.4%
156	Polymyositis	4.4%
157	Polydactyly	4.4%
158	Brachydactyly	4.4%
159	Plagiocephaly	4.4%
160	Lower Extremity Deformities, Congenital	4.4%
161	Upper Extremity Deformities, Congenital	4.4%
162	Jaw Abnormalities	4.3%
163	Chronic Fatigue Syndrome	4.3%
164	Cockayne Syndrome	4.3%
165	Nail-Patella Syndrome	4.1%
166	Giant Cell Epulis	4.1%
167	Muscle Weakness	4.1%
168	Musculoskeletal Pain	4%
169	Familial Periodic Paralysis	4%
170	Arthralgia	4%
171	Polyarthralgia	4%
172	Nose Neoplasms	3.8%
173	Rheumatoid Vasculitis	3.8%
174	Prognathism	3.8%
175	Renal Osteodystrophy	3.6%
176	Renal rickets	3.6%
177	Hip Dislocation	3.4%
178	Shoulder Dislocation	3.4%
179	Laryngomalacia	3.4%
180	Hip Dysplasia	3.4%
181	Muscular Dystrophy	3.4%
182	Orbital Myositis	3.4%
183	Dupuytren Contracture	3.3%
184	Myalgia	3.3%
185	Pyomyositis	3.3%
186	Sicca Syndrome	3.3%
187	Sjogren's Syndrome	3.3%
188	Micrognathism	3%
189	Pierre Robin Syndrome	3%
190	Myotonic Dystrophy	2.9%
191	Maxillofacial Abnormalities	2.7%
192	Myotonia Congenita	2.6%
193	Retrognathia	2.6%
194	Bronchomalacia	2.6%
195	Tracheomalacia	2.6%
196	Microcephaly	2.6%
197	Macrocephaly	2.6%
198	Hypokalemic periodic paralysis	2.6%
199	Shoulder Pain	2.6%
200	Welander Distal Myopathy	2.4%
201	Mitochondrial Encephalomyopathies	2.2%
202	Cleft Palate	2.1%
203	Dermatomyositis	2%
204	Muscular Dystrophy, Duchenne	2%
205	Porencephaly	1.9%
206	Noonan Syndrome	1.9%
207	Familial Hypophosphatemic Rickets	1.8%
208	Holoprosencephaly	1.7%
209	Radicular Cyst	1.3%
210	MELAS Syndrome	1%
211	Kearns-Sayre syndrome	0.9%

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