MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Mitochondrial Diseases

(UMLS:C0751651)

Definition:: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
UMLS ID:: C0751651
MeSH ID:: D028361

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.660

Synonym(s)

Mitochondrial Diseases

Mitochondrial disease

disease mitochondrial

disorders mitochondrial

mitochondrial disease

mitochondrial disease/disorder

mitochondrial diseases

mitochondrial disorder

mitochondrial disorders

Associated Drug(s)

	Name	Reference(s)	Data Source
1	2,3,5,4'-tetrahydroxystilbene 2-O-glucopyranoside	19890356	CTD
2	3-(2,2,2-trimethylhydrazine)propionate	2546223	CTD
3	Acetylcarnitine	20414966	CTD
4	Bezafibrate	17499714	CTD
5	Cadmium Compounds	21146384 22345309	CTD
6	Calcium Compounds	22345309	CTD
7	Carboplatin	10401022	CTD
8	Carnitine	12408365	CTD
9	Chloramphenicol	16207263	CTD
10	Clofibrate	17499714	CTD
11	Copper	21146384	CTD
12	Daunorubicin	6929617 11391408	CTD
13	Didanosine	20702595	CTD
14	Doxorubicin	View details 1159813 1277204 1702908 2116226 2724636 7066898 8290867 8937490 9917329 9952311 12379319 12408365 14502845 14745846 15605432 15792986 16157314 16209265 19139834 19286953 19303434 19429816 19890356 20096298 20132857 20845809	CTD
15	Ganciclovir	12691611	CTD
16	Gemfibrozil	17499714	CTD
17	Idarubicin	6929617	CTD
18	Ifosfamide	10401022	CTD
19	Indomethacin	22214982	CTD
20	Isoproterenol	2546223	CTD
21	Lamivudine	20702595	CTD
22	Mercury Compounds	21146384	CTD
23	Mitoxantrone	7101322	CTD
24	Nicotine	20960268	CTD
25	Peroxynitrous Acid	19286953	CTD
26	Pilocarpine	20206232	CTD
27	Progesterone	22486171	CTD
28	Pyruvic Acid	8232219	CTD
29	Quercetin	22214982	CTD
30	Razoxane	20132857	CTD
31	Resveratrol	19303434 22214982 24365713	CTD
32	Ribavirin	11214134	CTD
33	Rosiglitazone	20960268	CTD
34	Rotenone	20414966 26075822	CTD
35	Rutin	22214982	CTD
36	Sertraline	22387747	CTD
37	Stavudine	10906833 15507236 20702595	CTD
38	Tetracycline	9441722	CTD
39	Thioctic Acid	20414966	CTD
40	Tolcapone	11052337	CTD
41	Ubiquinone	15059613	CTD
42	Uridine	8232219 17187420	CTD
43	Valproic Acid	6412580 8099687	CTD
44	Zalcitabine	View details 7515130 8232219 11706061 17187420	CTD
45	Zidovudine	View details 9587562 10509500 15814907 20702595	CTD
46	caffeic acid phenethyl ester	14745846	CTD
47	ciglitazone	17499714	CTD
48	diphenyldiselenide	23103426	CTD
49	diphenylditelluride	23103426	CTD
50	ebselen	23103426	CTD
51	lamivudine, zidovudine drug combination	10509500	CTD
52	tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex	19286953	CTD
53	tetrandrine	20845809	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Acid-Base Imbalance	42.9%
2	Calcium Metabolism Disorders	42.9%
3	Iron Metabolism Disorders	42.9%
4	Phosphorus Metabolism Disorders	42.9%
5	Water-Electrolyte Imbalance	42.9%
6	Lipid Metabolism Disorders	42.9%
7	Glucose Metabolism Disorders	42.9%
8	Hypercalcemia	40.9%
9	Hypocalcemia	40.9%
10	Milk-Alkali Syndrome	40.9%
11	Wasting Syndrome	38.1%
12	Acidosis	31%
13	Alkalosis	31%
14	Amyloidosis	31%
15	Calcinosis	31%
16	Hyperglycemia	31%
17	Hyperinsulinism	31%
18	Hyperkalemia	31%
19	Hypernatremia	31%
20	Hypoglycemia	31%
21	Hypokalemia	31%
22	Hyponatremia	31%
23	Xanthomatosis	31%
24	Hypophosphatemia	31%
25	Metabolic acidosis	31%
26	Dyslipidemias	31%
27	Iron Overload	31%
28	Xanthoma	31%
29	Lipodystrophy	30.5%
30	Osteopenia	28.6%
31	Pseudohypoparathyroidism	28.3%
32	Brain Diseases, Metabolic	27.9%
33	Rickets	26.9%
34	Hyperlipoproteinemia Type IV	26.4%
35	Hyperlipoproteinemia Type V	26.4%
36	Acidosis, Lactic	25.4%
37	Calciphylaxis	25.4%
38	Hemosiderosis	25.4%
39	Ketosis	25.4%
40	Ketonuria	25.4%
41	Ketoacidosis	25.4%
42	Ketonemia	25.4%
43	Vascular calcification	25.4%
44	Hypolipoproteinemias	24.8%
45	Hyperhomocysteinemia	24.5%
46	Brain Diseases, Metabolic, Inborn	24.2%
47	Diabetic Ketoacidosis	23.7%
48	Hyperlipidemia, Familial Combined	23.5%
49	Nutrition Disorders	23.1%
50	Hyperlipoproteinemia Type III	22.8%
51	Hypercholesterolemia	22.7%
52	Hyperlipoproteinemias	22.7%
53	Hypertriglyceridemia	22.7%
54	Osteomalacia	22.3%
55	Hypoalphalipoproteinemias	22%
56	Diabetes Mellitus	22%
57	Lactose Intolerance	21.9%
58	Smith-Lemli-Opitz Syndrome	21.1%
59	Galactosemias	21%
60	Urea Cycle Disorders, Inborn	21%
61	Tyrosinemias	21%
62	Dehydration	20.9%
63	Lipomatosis	20.9%
64	Water Intoxication	20.9%
65	Werner Syndrome	20.9%
66	Familial Hypophosphatemic Rickets	20.9%
67	Gaucher Disease	20.6%
68	Congenital Hyperinsulinism	20.5%
69	Achlorhydria	20.5%
70	Amino Acid Metabolism, Inborn Errors	20.5%
71	Bloom Syndrome	20.5%
72	Carbohydrate Metabolism, Inborn Errors	20.5%
73	Metal Metabolism, Inborn Errors	20.5%
74	Osteoporosis	20.5%
75	Progeria	20.5%
76	Lysosomal Storage Diseases	20.5%
77	Bone Demineralization, Pathologic	20.5%
78	Peroxisomal Disorders	20.5%
79	Post-Traumatic Osteoporosis	20.5%
80	Celiac Disease	20.2%
81	Sprue, Tropical	20.2%
82	Steatorrhea	20.2%
83	Sprue	20.2%
84	Tay-Sachs Disease	19.4%
85	Glycogen storage disease type II	19.3%
86	Hyperphosphaturia	18.3%
87	Niemann-Pick Disease, Type C	18%
88	Nesidioblastosis	17.9%
89	Homocystinuria	17.9%
90	Leigh Disease	17.7%
91	Amyloid Neuropathies, Familial	17.2%
92	Acidosis, Respiratory	16.9%
93	Adiposis Dolorosa	16.9%
94	Alkalosis, Respiratory	16.9%
95	Alkaptonuria	16.7%
96	Glycogen Storage Disease	16.7%
97	Hypophosphatasia	16.7%
98	Insulin Resistance	16.7%
99	Osteoporosis, Postmenopausal	16.7%
100	Propionic acidemia	16.7%
101	Dihydropyrimidine Dehydrogenase Deficiency	16.7%
102	Cystinosis	16.7%
103	Carbamoyl-Phosphate Synthase I Deficiency Disease	16.4%
104	Renal tubular acidosis	16.3%
105	Fabry Disease	15.9%
106	Neuronal Ceroid-Lipofuscinoses	15.7%
107	Myelinolysis, Central Pontine	15.4%
108	Glycosuria	15.1%
109	Reye Syndrome	15.1%
110	Hepatic Encephalopathy	15%
111	Glycogen Storage Disease Type I	14.8%
112	Glycogen Storage Disease Type V	14.8%
113	Mucopolysaccharidosis III	14.6%
114	Child Nutrition Disorders	14.3%
115	Hypervitaminosis A	14.3%
116	Infant Nutrition Disorders	14.3%
117	Malnutrition	14.3%
118	HIV-Associated Lipodystrophy Syndrome	14.1%
119	Renal Osteodystrophy	13.9%
120	Renal rickets	13.9%
121	Adrenoleukodystrophy	13.7%
122	Zellweger Syndrome	13.5%
123	Menkes Kinky Hair Syndrome	13.3%
124	HIV Wasting Syndrome	13.3%
125	Gestational Diabetes	13%
126	Latent Autoimmune Diabetes in Adults	13%
127	Diabetes Mellitus, Experimental	12.8%
128	Nephrocalcinosis	12.5%
129	Tetany	12.5%
130	Hepatolenticular Degeneration	12.4%
131	Porphyrias, Hepatic	12.3%
132	Cerebral Amyloid Angiopathy	12.3%
133	Wernicke Encephalopathy	12.2%
134	Glycosuria, Renal	12.2%
135	Refsum Disease	12.2%
136	Necrobiosis Lipoidica Diabeticorum	12.1%
137	Fanconi Anemia	11.9%
138	Deficiency Diseases	10.3%
139	Starvation	10.3%
140	Refeeding Syndrome	10.3%
141	Familial Periodic Paralysis	10.1%
142	Primary amyloidosis	10.1%
143	Mitochondrial Encephalomyopathies	9.9%
144	Variegate Porphyria	9.9%
145	Acute intermittent porphyria	9.9%
146	Porphyria Cutanea Tarda	9.9%
147	Renal Aminoacidurias	9.8%
148	Fanconi Syndrome	9.8%
149	Pseudohypoaldosteronism	9.8%
150	Liddle Syndrome	9.8%
151	Canavan Disease	9.8%
152	Alexander Disease	9.8%
153	MELAS Syndrome	9.7%
154	Mucopolysaccharidosis II	9.7%
155	Sjogren-Larsson Syndrome	9.3%
156	Hypokalemic periodic paralysis	8.9%
157	Frontotemporal dementia	8.8%
158	Cystinuria	8.8%
159	Kernicterus	8.7%
160	Cockayne Syndrome	8.6%
161	Kwashiorkor	8.5%
162	Magnesium Deficiency	8.5%
163	Potassium Deficiency	8.5%
164	Protein Deficiency	8.5%
165	Avitaminosis	8.5%
166	Gout	8.4%
167	Amyotrophic Lateral Sclerosis	8.4%
168	Antley-Bixler Syndrome Phenotype	8.2%
169	Ataxia Telangiectasia	7.6%
170	Ascorbic Acid Deficiency	7.6%
171	Vitamin A Deficiency	7.6%
172	Vitamin D Deficiency	7.6%
173	Vitamin E Deficiency	7.6%
174	Marasmus	7.6%
175	Arthritis, Gouty	7.4%
176	Folic Acid Deficiency	7.1%
177	Pellagra	7.1%
178	Thiamine Deficiency	7.1%
179	Vitamin B 12 Deficiency	7.1%
180	Vitamin B 6 Deficiency	7.1%
181	Pyridoxine Deficiency	7.1%
182	CREST Syndrome	7%
183	Beriberi	6.9%
184	Xeroderma Pigmentosum	6.8%
185	Albinism	6.3%
186	Ichthyosis, X-Linked	5%
187	Anemia, Pernicious	4.5%
188	Obesity, Abdominal	4.1%
189	Obesity	3.9%
190	Vitamin K Deficiency	3.8%
191	Scurvy	3.5%
192	Pediatric Obesity	3.2%
193	Prader-Willi Syndrome	2.8%
194	Subacute Combined Degeneration	2.3%

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