MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Arachnodactyly

(UMLS:C0003706)

Definition:: An abnormal bone development that is characterized by extra long and slender hands and fingers, such that the clenched thumb extends beyond the ulnar side of the hand. Arachnodactyly can include feet and toes. Arachnodactyly has been associated with several gene mutations and syndromes.
UMLS ID:: C0003706
MeSH ID:: D054119

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.660.585.174

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.585.174

Synonym(s)

Arachnodactyly

ARACHNODACTYLY

Congenital arachnodactyly

DOLICHOSTENOMELIA

Dolichostenomelia

HAND SPIDERLIKE

Long slender fingers

Long, slender fingers

Spider finger

10.

Spider fingers

11.

arachnodactyly

12.

dolichostenomelia

13.

fingers spider

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Valproic Acid	FAERS: 23	US FAERS
2	Valproic Acid	FAERS: 7	US FAERS
3	Topiramate	FAERS: 4	US FAERS
4	Fluconazole	FAERS: 1	US FAERS
5	Valproic Acid	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Amelia	47.5%
2	Ectromelia	47.5%
3	Hemimelia	47.5%
4	Phocomelia	47.5%
5	Sirenomelia	47.5%
6	Polydactyly	47.5%
7	Brachydactyly	47.5%
8	Lower Extremity Deformities, Congenital	47.5%
9	Upper Extremity Deformities, Congenital	47.5%
10	Syndactyly	40.3%
11	Craniofacial Abnormalities	32.8%
12	Poland Syndrome	30%
13	Arthrogryposis	29.1%
14	Pectus excavatum	28.9%
15	Acrocephalosyndactylia	28.4%
16	Klippel-Feil Syndrome	28%
17	Synostosis	28%
18	Gastroschisis	26%
19	Craniosynostosis	25.4%
20	Brachycephaly	25.4%
21	Talipes	24%
22	Pectus carinatum	23.7%
23	Plagiocephaly	21.3%
24	Congenital clubfoot	20.7%
25	Vertical Talus	20.7%
26	Maxillofacial Abnormalities	19.4%
27	Holoprosencephaly	19.4%
28	Craniofacial Dysostosis	19%
29	Platybasia	18.7%
30	Rubinstein-Taybi Syndrome	18.2%
31	Abnormalities, Drug-Induced	16.9%
32	Situs Inversus	16.9%
33	Microcephaly	16.5%
34	Macrocephaly	16.5%
35	Antley-Bixler Syndrome Phenotype	14.2%
36	Beckwith-Wiedemann Syndrome	13.9%
37	Wolf-Hirschhorn Syndrome	13.9%
38	Noonan Syndrome	13.3%
39	Eye Abnormalities	13.3%
40	Cardiovascular Abnormalities	13.3%
41	Laryngomalacia	13.2%
42	Jaw Abnormalities	13.1%
43	Porencephaly	12.9%
44	Skin Abnormalities	12.8%
45	Lymphatic Abnormalities	12.8%
46	Congenital Microtia	12.8%
47	Congenital diaphragmatic hernia	12.5%
48	Mandibulofacial Dysostosis	11.9%
49	Goldenhar Syndrome	11.9%
50	Bone Diseases	11.8%
51	Fasciitis	11.8%
52	Foot Deformities	11.8%
53	Arthropathy	11.8%
54	Smith-Magenis syndrome	11.7%
55	Cri-du-Chat Syndrome	11.5%
56	Down Syndrome	11.5%
57	Trisomy 21	11.5%
58	Aicardi's syndrome	11.3%
59	Nail-Patella Syndrome	11.3%
60	Urogenital Abnormalities	10.6%
61	Genetic Diseases, Inborn	10.6%
62	Contracture	10.3%
63	Osteoarthropathy, Secondary Hypertrophic	10.3%
64	Fasciitis, Plantar	10.3%
65	Micrognathism	10%
66	Pierre Robin Syndrome	10%
67	Ectodermal Dysplasia	10%
68	Aplasia Cutis Congenita	10%
69	Prune Belly Syndrome	9.9%
70	Twins, Conjoined	9.9%
71	Waardenburg Syndrome	9.9%
72	Anencephaly	9.9%
73	Prader-Willi Syndrome	9.9%
74	Bronchomalacia	9.8%
75	Tracheomalacia	9.8%
76	CHARGE Syndrome	9.4%
77	Prognathism	9.4%
78	Jaw Diseases	9.2%
79	Cleft Palate	9.1%
80	Marfan Syndrome	9%
81	Retrognathia	8.9%
82	Cartilage Diseases	8.8%
83	Foot Diseases	8.8%
84	Myopathy	8.8%
85	Rheumatism	8.8%
86	Chondromalacia	8.8%
87	Dural Arteriovenous Fistula	8.3%
88	Dextrocardia	8.2%
89	Fibromyalgia	8.2%
90	Osteochondritis	8.2%
91	Polymyalgia Rheumatica	8.2%
92	Metatarsalgia	8.1%
93	Fetal Diseases	8%
94	Xeroderma	7.8%
95	Mobius Syndrome	7.8%
96	Gout	7.6%
97	Anophthalmos	7.6%
98	Anus, Imperforate	7.6%
99	Hydranencephaly	7.6%
100	Microphthalmos	7.6%
101	Multiple Epiphyseal Dysplasia	7.6%
102	Neural Tube Defects	7.6%
103	Osteochondrodysplasias	7.6%
104	Tethered Cord Syndrome	7.6%
105	Iniencephaly	7.6%
106	Craniorachischisis	7.6%
107	Exencephaly	7.6%
108	Septo-Optic Dysplasia	7.6%
109	Cortical Dysplasia	7.6%
110	Malformations of Cortical Development	7.6%
111	Anorectal Malformations	7.6%
112	Bloom Syndrome	7.4%
113	Cockayne Syndrome	7.4%
114	Kartagener Syndrome	7.4%
115	Abnormalities, Radiation-Induced	7.1%
116	Osteoarthritis, Spine	6.8%
117	Arthritis	6.7%
118	Bone Diseases, Developmental	6.7%
119	Bursitis	6.7%
120	Hyperostosis	6.7%
121	Joint Instability	6.7%
122	Myofascial Pain Syndromes	6.7%
123	Osteitis	6.7%
124	Osteitis Deformans	6.7%
125	Osteochondrosis	6.7%
126	Rhabdomyolysis	6.7%
127	Spinal Diseases	6.7%
128	Synovitis	6.7%
129	Joint laxity	6.7%
130	Polyarthritis	6.7%
131	Frozen shoulder	6.7%
132	Patellofemoral Pain Syndrome	6.7%
133	Rheumatic Fever	6.7%
134	Ischemic contracture	6.6%
135	Hip Contracture	6.6%
136	Periarthritis	6.6%
137	Polycystic Kidney Diseases	6.5%
138	Williams Syndrome	6.5%
139	Scimitar Syndrome	6.4%
140	Temporomandibular Joint Disorders	6.3%
141	Dwarfism	6.3%
142	Blepharophimosis	6.1%
143	Laryngostenosis	6.1%
144	Mouth Abnormalities	6.1%
145	Esophageal Atresia	6%
146	Intestinal Atresia	6%
147	Horseshoe Kidney	6%
148	Muscular Dystrophy	6%
149	Acrodermatitis	6%
150	Lymphangiectasis, Intestinal	6%
151	Gianotti-Crosti Syndrome	6%
152	Retinal Dysplasia	5.9%
153	Aniridia	5.8%
154	Cystic Fibrosis	5.8%
155	Osteoarthritis, Knee	5.7%
156	Epidermolysis Bullosa	5.7%
157	Ankylosing spondylitis	5.7%
158	Basal Cell Nevus Syndrome	5.7%
159	Rheumatoid Arthritis	5.6%
160	Juvenile arthritis	5.6%
161	Alstrom Syndrome	5.6%
162	Abdominal Cramps	5.6%
163	Amniotic Band Syndrome	5.6%
164	Asphyxia Neonatorum	5.6%
165	Infant, Premature, Diseases	5.6%
166	Infantile Colic	5.6%
167	Temporomandibular Joint Dysfunction Syndrome	5.6%
168	Fragile X Syndrome	5.5%
169	Osteogenesis Imperfecta	5.3%
170	Arthritis, Gouty	5.3%
171	Bone Diseases, Endocrine	5.3%
172	Gigantism	5.3%
173	Spinal Neoplasms	5.3%
174	Spondylitis	5.3%
175	Primary Ciliary Dyskinesia	5.3%
176	Smith-Lemli-Opitz Syndrome	5.3%
177	Choanal Atresia	5.1%
178	Tracheobronchomegaly	5.1%
179	Laryngocele	5.1%
180	Bone Diseases, Infectious	5.1%
181	Bone neoplasms	5.1%
182	Compartment syndromes	5.1%
183	Maxillary Diseases	5.1%
184	Osteopenia	5.1%
185	Tendinitis	5.1%
186	Tendinopathy	5.1%
187	Choledochal Cyst	5.1%
188	Hermaphroditism	5.1%
189	Disorders of Sex Development	5.1%
190	Ichthyosis, X-Linked	5.1%
191	Bone Resorption	5%
192	Hemarthrosis	5%
193	Myositis	5%
194	Tietze's Syndrome	5%
195	Isaacs syndrome	5%
196	Aseptic Necrosis of Bone	5%
197	Myotonic Disorders	5%
198	Cryptorchidism	5%
199	Hypospadias	5%
200	Central Nervous System Cysts	5%
201	Dandy-Walker Syndrome	5%
202	Ectopia Cordis	4.9%
203	Meningomyelocele	4.9%
204	Spina Bifida	4.9%
205	POEMS Syndrome	4.9%
206	Single umbilical artery	4.9%
207	Muscular Dystrophy, Duchenne	4.9%
208	Meconium Aspiration Syndrome	4.9%
209	Congenital Hypothyroidism	4.8%
210	Myotonic Dystrophy	4.7%
211	Arthritis, Psoriatic	4.7%
212	Classical Lissencephalies and Subcortical Band Heterotopias	4.7%
213	Rheumatoid Nodule	4.6%
214	Turner Syndrome	4.5%
215	Spondylarthropathies	4.5%
216	Pseudoxanthoma Elasticum	4.4%
217	Neoplastic Syndromes, Hereditary	4.4%
218	Familial Periodic Paralysis	4.4%
219	Ainhum	4.4%
220	Bunion	4.4%
221	Dysostoses	4.4%
222	Fibrodysplasia Ossificans Progressiva	4.4%
223	Myoglobinuria	4.4%
224	Myositis Ossificans	4.4%
225	Spinal Stenosis	4.4%
226	Spondylosis	4.4%
227	Tenosynovitis	4.4%
228	Intervertebral Disc Degeneration	4.4%
229	Sacroiliitis	4.4%
230	Polycystic Kidney, Autosomal Dominant	4.3%
231	Bladder Exstrophy	4.3%
232	Epispadias	4.3%
233	Multicystic Dysplastic Kidney	4.3%
234	Anemia, Neonatal	4.2%
235	Pelger-Huet Anomaly	4.2%
236	Persistent Fetal Circulation Syndrome	4.2%
237	Werner Syndrome	4.2%
238	Myasthenic Syndromes, Congenital	4.2%
239	Arthritis, Reactive	4.2%
240	Umbilical hernia	4.1%
241	Medial Tibial Stress Syndrome	4.1%
242	Mitochondrial Myopathies	4%
243	Xeroderma Pigmentosum	4%
244	Muscle Cramp	4%
245	Eosinophilia-Myalgia Syndrome	4%
246	Sjogren-Larsson Syndrome	4%
247	Muscle Rigidity	4%
248	Muscle Spasticity	4%
249	Cogwheel Rigidity	4%
250	Nuchal Rigidity	4%
251	Aortic coarctation	3.9%
252	Cor Triatriatum	3.9%
253	Coronary Vessel Anomalies	3.9%
254	Dental Enamel Hypoplasia	3.9%
255	Patent ductus arteriosus	3.9%
256	Ebstein Anomaly	3.9%
257	Heart Septal Defects	3.9%
258	Hypodontia	3.9%
259	Macrostomia	3.9%
260	Meningocele	3.9%
261	Microstomia	3.9%
262	Tetralogy of Fallot	3.9%
263	Transposition of Great Vessels	3.9%
264	Hypoplastic Left Heart Syndrome	3.9%
265	May-Thurner Syndrome	3.9%
266	Encephalocele	3.9%
267	Welander Distal Myopathy	3.9%
268	Discitis	3.9%
269	Wolff-Parkinson-White Syndrome	3.9%
270	Kallmann Syndrome	3.9%
271	Myotonia Congenita	3.8%
272	Felty Syndrome	3.8%
273	Klinefelter Syndrome	3.8%
274	Charcot-Marie-Tooth Disease	3.7%
275	Dermal Sinus	3.6%
276	Spina Bifida Cystica	3.6%
277	Spina Bifida Occulta	3.6%
278	Lissencephaly	3.6%
279	Polymicrogyria	3.6%
280	Pachygyria	3.6%
281	Schizencephaly	3.6%
282	Periventricular Nodular Heterotopia	3.6%
283	Zellweger Syndrome	3.5%
284	Chronic Fatigue Syndrome	3.5%
285	Neonatal Abstinence Syndrome	3.4%
286	Hyperkeratosis, Epidermolytic	3.4%
287	Giant Cell Epulis	3.4%
288	Muscle Weakness	3.4%
289	Arthritis, Infectious	3.4%
290	Fetal Growth Retardation	3.4%
291	Musculoskeletal Pain	3.3%
292	Fetal Hypoxia	3.3%
293	Congenital nystagmus	3.3%
294	Fetal Alcohol Spectrum Disorders	3.3%
295	Anterior Compartment Syndrome	3.3%
296	Osteomyelitis	3.3%
297	Osteoporosis	3.3%
298	Periostitis	3.3%
299	Enthesopathy	3.3%
300	Bone Demineralization, Pathologic	3.3%
301	Post-Traumatic Osteoporosis	3.3%
302	Arthritis, Experimental	3.3%
303	Abdominal Compartment Syndrome	3.3%
304	Toxoplasmosis, Congenital	3.3%
305	Arthralgia	3.3%
306	Long QT Syndrome	3.3%
307	Familial Mediterranean Fever	3.3%
308	Polyarthralgia	3.3%
309	Tricuspid Atresia	3.3%
310	Arrhythmogenic Right Ventricular Dysplasia	3.3%
311	Syphilis, Congenital	3.3%
312	Anemia, Sickle Cell	3.3%
313	Thalassemia	3.3%
314	Alveolar Bone Loss	3.3%
315	Femur Head Necrosis	3.3%
316	Gonadal Dysgenesis	3.3%
317	Polymyositis	3.3%
318	Adrenogenital Syndrome	3.3%
319	Ovotesticular Disorders of Sex Development	3.3%
320	Osteolysis	3.3%
321	Rheumatoid Vasculitis	3.3%
322	Chondrodysplasia Punctata	3.3%
323	Enchondromatosis	3.3%
324	Lordosis	3.3%
325	Osteosclerosis	3.3%
326	Spondylolysis	3.3%
327	kyphosis	3.3%
328	Kashin-Beck Disease	3.3%
329	Tuberculosis, Spinal	3.2%
330	Tuberous Sclerosis	3.2%
331	Refsum Disease	3%
332	Hypokalemic periodic paralysis	3%
333	Albinism	2.9%
334	Aortopulmonary Septal Defect	2.9%
335	Double Outlet Right Ventricle	2.9%
336	Endocardial Cushion Defects	2.9%
337	Myocardial bridging	2.9%
338	Aorticopulmonary Septal Defect	2.9%
339	Hyperandrogenism	2.9%
340	Sicca Syndrome	2.9%
341	Sjogren's Syndrome	2.9%
342	Eosinophilic Granuloma	2.8%
343	Autoimmune Lymphoproliferative Syndrome	2.8%
344	Myalgia	2.8%
345	Pseudohypoparathyroidism	2.8%
346	Congenital Hyperinsulinism	2.8%
347	Chorioamnionitis	2.8%
348	Angioedemas, Hereditary	2.7%
349	Hip Dislocation	2.7%
350	Shoulder Dislocation	2.7%
351	Hip Dysplasia	2.7%
352	Melorheostosis	2.7%
353	Osteopetrosis	2.7%
354	Spondylolisthesis	2.7%
355	Orbital Myositis	2.7%
356	Dupuytren Contracture	2.7%
357	Palatal Neoplasms	2.7%
358	Pyomyositis	2.6%
359	Acromegaly	2.6%
360	Joint Tuberculosis	2.6%
361	Tuberculosis, Osteoarticular	2.6%
362	Bone Tuberculosis	2.6%
363	Rett Syndrome	2.6%
364	Paralysis, Obstetric	2.5%
365	Retinopathy of Prematurity	2.5%
366	Amino Acid Metabolism, Inborn Errors	2.5%
367	Carbohydrate Metabolism, Inborn Errors	2.5%
368	Metal Metabolism, Inborn Errors	2.5%
369	Progeria	2.5%
370	Lysosomal Storage Diseases	2.5%
371	Cytochrome-c Oxidase Deficiency	2.5%
372	Peroxisomal Disorders	2.5%
373	Wiskott-Aldrich Syndrome	2.5%
374	Bronchopulmonary Dysplasia	2.5%
375	Osteoporosis, Postmenopausal	2.4%
376	Romano-Ward Syndrome	2.4%
377	Truncus Arteriosus, Persistent	2.4%
378	Mucopolysaccharidosis II	2.2%
379	Rickets	2.2%
380	Menkes Kinky Hair Syndrome	2.2%
381	Shoulder Pain	2.2%
382	Sickle Cell Trait	2.2%
383	Neuronal Ceroid-Lipofuscinoses	2.1%
384	Ophthalmia Neonatorum	2%
385	Respiratory Distress Syndrome, Newborn	2%
386	Cutis Laxa	2%
387	Retinitis Pigmentosa	2%
388	Pigmentary retinopathy	2%
389	Porokeratosis	2%
390	Keratoderma, Palmoplantar	2%
391	Chronic granulomatous disease	2%
392	Mastoiditis	1.9%
393	Petrositis	1.9%
394	Mitochondrial Encephalomyopathies	1.9%
395	Ataxia Telangiectasia	1.9%
396	Arteriovenous fistula	1.8%
397	Amyloid Neuropathies, Familial	1.8%
398	Hepatolenticular Degeneration	1.8%
399	Adrenoleukodystrophy	1.7%
400	Duane Retraction Syndrome	1.7%
401	Porphyrias, Hepatic	1.7%
402	Dermatomyositis	1.7%
403	Acute Chest Syndrome	1.7%
404	Peutz-Jeghers Syndrome	1.7%
405	Hydrops Fetalis	1.6%
406	Thrombasthenia	1.6%
407	Antithrombin III Deficiency	1.6%
408	Protein C Deficiency	1.6%
409	Brain Diseases, Metabolic, Inborn	1.6%
410	Afibrinogenemia	1.6%
411	Dystonia Musculorum Deformans	1.6%
412	Factor VII Deficiency	1.6%
413	Factor X Deficiency	1.6%
414	Factor XII Deficiency	1.6%
415	Hemophilia A	1.6%
416	Leukomalacia, Periventricular	1.6%
417	Activated Protein C Resistance	1.6%
418	Factor II deficiency	1.6%
419	Factor VIII Deficiency	1.6%
420	Factor V deficiency	1.6%
421	Factor XI Deficiency	1.6%
422	Hypoprothrombinemias	1.6%
423	Fanconi Anemia	1.6%
424	Nesidioblastosis	1.6%
425	Alkaptonuria	1.6%
426	Glycogen Storage Disease	1.6%
427	Hypophosphatasia	1.6%
428	Propionic acidemia	1.6%
429	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
430	Cystinosis	1.6%
431	Lafora Disease	1.6%
432	Unverricht-Lundborg Syndrome	1.6%
433	Anemia, Diamond-Blackfan	1.6%
434	Galactosemias	1.6%
435	Urea Cycle Disorders, Inborn	1.6%
436	Tyrosinemias	1.6%
437	Osteomalacia	1.6%
438	Fabry Disease	1.5%
439	Denys-Drash Syndrome	1.5%
440	Multiple Endocrine Neoplasia	1.5%
441	MELAS Syndrome	1.5%
442	Canavan Disease	1.5%
443	Alexander Disease	1.5%
444	Optic Atrophy, Hereditary, Leber	1.4%
445	Glycogen storage disease type II	1.4%
446	Hyperphosphaturia	1.4%
447	Dermatitis, Atopic	1.4%
448	Mucopolysaccharidosis III	1.4%
449	Hyaline Membrane Disease	1.3%
450	Hypolipoproteinemias	1.3%
451	Papillon-Lefevre Disease	1.3%
452	Hyperlipidemia, Familial Combined	1.3%
453	Hyperlipoproteinemia Type III	1.3%
454	Homocystinuria	1.3%
455	Leigh Disease	1.3%
456	Familial Hypophosphatemic Rickets	1.3%
457	Kernicterus	1.3%
458	Behcet Syndrome	1.2%
459	Glycogen Storage Disease Type I	1.2%
460	Glycogen Storage Disease Type V	1.2%
461	Radicular Cyst	1.2%
462	Nose Neoplasms	1.1%
463	Huntington Disease	1.1%
464	Lactose Intolerance	1.1%
465	Variegate Porphyria	1.1%
466	Acute intermittent porphyria	1.1%
467	Porphyria Cutanea Tarda	1.1%
468	Hyperhomocysteinemia	1.1%
469	Gaucher Disease	1.1%
470	Renal Osteodystrophy	1.1%
471	Renal rickets	1.1%
472	Renal Aminoacidurias	1.1%
473	Fanconi Syndrome	1.1%
474	Pseudohypoaldosteronism	1.1%
475	Liddle Syndrome	1.1%
476	Hyperlipoproteinemia Type IV	1.1%
477	Hyperlipoproteinemia Type V	1.1%
478	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.1%
479	Nephroblastoma	1%
480	Hypoalphalipoproteinemias	1%
481	Multiple Endocrine Neoplasia Type 1	0.9%
482	Friedreich Ataxia	0.9%
483	Renal tubular acidosis	0.9%
484	Tay-Sachs Disease	0.9%
485	Niemann-Pick Disease, Type C	0.9%
486	Adenomatous Polyposis Coli	0.9%
487	Kearns-Sayre syndrome	0.8%
488	Cystinuria	0.8%
489	Glycosuria, Renal	0.7%

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