MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Necrobiosis Lipoidica Diabeticorum

(UMLS:C0392445)

UMLS ID:: C0392445
MeSH ID:: D009335

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.200.495.545|C17.800.550.545|C17.800.849.495

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.880.495

Synonym(s)

Necrobiosis Lipoidica Diabeticorum

Appenheim's disease

Diabetic necrobiosis lipoidica

NLD - Necrobiosis lipoidica diabeticorum

Necrobiosis diabeticorum

Necrobiosis lipoidica diabetic

Necrobiosis lipoidica diabeticorum

OPPENHEIM-URBACH DISEASE

Oppenheim-Urbach

10.

Oppenheim-Urbach disease

11.

Urbach-Oppenheim

12.

necrobiosis diabeticorum

13.

necrobiosis lipoidica diabetic

14.

necrobiosis lipoidica diabeticorum

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Levetiracetam	FAERS: 11	US FAERS
2	Olanzapine	FAERS: 1	US FAERS
3	Quetiapine Fumarate	FAERS: 1	US FAERS
4	Topiramate	FAERS: 1	US FAERS
5	Valproic Acid	FAERS: 1	US FAERS
6	Aripiprazole		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Lipodystrophy	39.3%
2	Lupus Erythematosus, Cutaneous	38.4%
3	Panniculitis	38.4%
4	Systemic Scleroderma	38.4%
5	Morphea	38.4%
6	Pyoderma Gangrenosum	38.4%
7	Granuloma Annulare	37.3%
8	Xeroderma Pigmentosum	33.4%
9	Panniculitis, Lupus Erythematosus	31.3%
10	Dermatitis, Atopic	29.9%
11	Epidermolysis Bullosa	29.9%
12	Acne Vulgaris	29.8%
13	Contact Dermatitis	29.8%
14	Eczema	29.8%
15	Erythema Multiforme	29.8%
16	Intertrigo	29.8%
17	Neurodermatitis	29.8%
18	Rhinophyma	29.8%
19	Perioral Dermatitis	29.8%
20	Acne	29.8%
21	Lipomatosis	29.6%
22	Dermatomyositis	28.4%
23	Dermatitis, Phototoxic	28%
24	Pityriasis Lichenoides et Varioliformis Acuta	28%
25	Pityriasis Lichenoides	28%
26	Phototoxicity	28%
27	Breast Diseases	27.5%
28	Dermatitis	27.5%
29	Exanthema	27.5%
30	Facial Dermatoses	27.5%
31	Hair Diseases	27.5%
32	Hand Dermatoses	27.5%
33	keratoacanthoma	27.5%
34	Keratosis	27.5%
35	Nail Diseases	27.5%
36	Photosensitivity Disorders	27.5%
37	Prurigo	27.5%
38	Pyoderma	27.5%
39	Rosacea	27.5%
40	Sebaceous Gland Diseases	27.5%
41	Skin Diseases, Vesiculobullous	27.5%
42	Skin Ulcer	27.5%
43	Sweat Gland Diseases	27.5%
44	Skin Diseases, Papulosquamous	27.5%
45	Skin Diseases, Vascular	27.5%
46	Acneiform Eruptions	27.5%
47	Ocular Rosacea	27.5%
48	Subcorneal pustular dermatosis	27.5%
49	Erythematotelangiectatic Rosacea	27.5%
50	Papulopustular Rosacea	27.5%
51	Chronic Actinic Dermatitis	27.5%
52	Erythema Induratum	26%
53	Cutis Laxa	25.8%
54	Dermatitis Herpetiformis	25.8%
55	Foot Ulcer	25.8%
56	Acrodermatitis	25.6%
57	Sebaceous Gland Neoplasms	25.6%
58	Porokeratosis	25.6%
59	Gianotti-Crosti Syndrome	25.6%
60	Keratoderma, Palmoplantar	25.6%
61	Pseudoxanthoma Elasticum	24.5%
62	Dermatitis, Photoallergic	24.5%
63	Lupus Erythematosus, Discoid	24.3%
64	Scleroderma, Limited	24.3%
65	Foot Diseases	23.7%
66	Skin Abnormalities	23.2%
67	Skin Diseases, Infectious	23.2%
68	Skin Neoplasms	23.2%
69	Pigmentation Disorders	23.2%
70	Pruritus	22.9%
71	Erythema	22.9%
72	Necrolytic Migratory Erythema	22.9%
73	Cutaneous Fistula	22.9%
74	Nephrogenic Fibrosing Dermopathy	22.9%
75	Nephrogenic Systemic Fibrosis	22.9%
76	Xeroderma	22.6%
77	Urticaria Pigmentosa	22%
78	Dermatitis, Irritant	21.9%
79	Acne Conglobata	21.9%
80	Sjogren-Larsson Syndrome	21%
81	HIV-Associated Lipodystrophy Syndrome	20.2%
82	Ectodermal Dysplasia	19.9%
83	Aplasia Cutis Congenita	19.9%
84	Adiposis Dolorosa	19.8%
85	Toxic Epidermal Necrolysis	19.6%
86	Stevens-Johnson Syndrome	19.6%
87	Erythema Infectiosum	19.6%
88	Mastocytosis	19.5%
89	Exanthema Subitum	19.5%
90	Dermatitis, Occupational	19.3%
91	Erythema Nodosum	19.3%
92	Ichthyosis, X-Linked	19.2%
93	Dermatitis, Allergic Contact	18.8%
94	Papillon-Lefevre Disease	18.7%
95	Mixed Connective Tissue Disease	18.1%
96	Mucinoses	18.1%
97	Diaper Rash	17.9%
98	Anhidrosis	17.9%
99	Cholesteatoma	17.9%
100	Pressure Ulcer	17.9%
101	Folliculitis	17.9%
102	Foot Dermatoses	17.9%
103	Gynecomastia	17.9%
104	Hypertrichosis	17.9%
105	Hypohidrosis	17.9%
106	Hypotrichosis	17.9%
107	Leg Ulcer	17.9%
108	Miliaria	17.9%
109	Parakeratosis	17.9%
110	Parapsoriasis	17.9%
111	Pityriasis	17.9%
112	Psoriasis	17.9%
113	Sweet Syndrome	17.9%
114	Hidradenitis	17.9%
115	Onycholysis	17.9%
116	Miliaria Rubra	17.9%
117	Hyperpigmentation	17.9%
118	Lichenoid Eruptions	17.9%
119	Chloracne	17.9%
120	Tinea Capitis	17.8%
121	Onychomycosis	17.8%
122	Hyperkeratosis, Epidermolytic	17.2%
123	Ecthyma	17.2%
124	Albinism	16.9%
125	Porphyrias, Hepatic	16.3%
126	Cartilage Diseases	15.6%
127	Rheumatism	15.6%
128	Chondromalacia	15.6%
129	Homocystinuria	15.6%
130	Behcet Syndrome	15.6%
131	Lupus Erythematosus, Systemic	15.3%
132	Overlap syndrome	15.3%
133	Acantholysis	15.1%
134	Breast Cyst	15.1%
135	Actinic keratosis	15.1%
136	Pemphigoid, Benign Mucous Membrane	15.1%
137	Pemphigus	15.1%
138	Piedra	15.1%
139	Sunburn	15.1%
140	Argyria	14.9%
141	Hirsutism	14.9%
142	Lactation Disorder	14.9%
143	Mastitis	14.9%
144	Urticaria	14.9%
145	Necrobiosis Lipoidica Diabeticorum	14.9%
146	Pruritus Vulvae	14.8%
147	Mastocytoma	14.8%
148	Pruritus Ani	14.8%
149	Hidradenitis Suppurativa	14.6%
150	Erythema Chronicum Migrans	13.9%
151	Osteogenesis Imperfecta	13.8%
152	Connective Tissue Diseases	13.8%
153	Keloid	13.6%
154	Wasting Syndrome	13.6%
155	CREST Syndrome	13.4%
156	Hypercalcemia	13.3%
157	Hypocalcemia	13.3%
158	Milk-Alkali Syndrome	13.3%
159	Tinea Pedis	13.2%
160	Lichen Planus	13.2%
161	Melanosis	13.2%
162	Chloasma	13.2%
163	Pityriasis Rosea	13.2%
164	Pityriasis Rubra Pilaris	13.2%
165	Vitiligo	13.2%
166	Lichen Nitidus	13.2%
167	Dermatomycoses	12.9%
168	Mucocutaneous Lymph Node Syndrome	12.9%
169	Skin Diseases, Bacterial	12.9%
170	Dupuytren Contracture	12.8%
171	Drug Eruptions	12.8%
172	Livedo Reticularis	12.8%
173	Malignant Atrophic Papulosis	12.8%
174	Polyarteritis Nodosa	12.7%
175	Takayasu Arteritis	12.7%
176	Menkes Kinky Hair Syndrome	12.5%
177	Pseudohypoparathyroidism	12.1%
178	Acid-Base Imbalance	12.1%
179	Calcium Metabolism Disorders	12.1%
180	Iron Metabolism Disorders	12.1%
181	Phosphorus Metabolism Disorders	12.1%
182	Water-Electrolyte Imbalance	12.1%
183	Lipid Metabolism Disorders	12.1%
184	Mitochondrial Diseases	12.1%
185	Glucose Metabolism Disorders	12.1%
186	Mycetoma	11.9%
187	Variegate Porphyria	11.9%
188	Acute intermittent porphyria	11.9%
189	Porphyria Cutanea Tarda	11.9%
190	Nail-Patella Syndrome	11.4%
191	Scleromyxedema	11.3%
192	Cellulitis	11.3%
193	Alopecia	11.1%
194	Sweating, Gustatory	11.1%
195	Androgenetic Alopecia	11.1%
196	Auriculotemporal Syndrome	11.1%
197	Leigh Disease	11.1%
198	Lice Infestations	11%
199	Varicose Ulcer	11%
200	Breast Neoplasms, Male	11%
201	Triple Negative Breast Neoplasms	11%
202	Galactorrhea	10.9%
203	Acanthosis Nigricans	10.8%
204	Alopecia Areata	10.8%
205	Lentigo	10.8%
206	Rickets	10.8%
207	Osteopenia	10.2%
208	Carbamoyl-Phosphate Synthase I Deficiency Disease	10.1%
209	Brain Diseases, Metabolic	10.1%
210	Brain Diseases, Metabolic, Inborn	9.9%
211	Mucopolysaccharidosis III	9.7%
212	Larva Migrans	9.5%
213	Leishmaniasis	9.5%
214	Molluscum Contagiosum	9.5%
215	Hyperhomocysteinemia	9.5%
216	Mesenteric Panniculitis	9.5%
217	Panniculitis, Peritoneal	9.5%
218	Tietze's Syndrome	9.5%
219	Orbital Cellulitis	9.5%
220	Myxoid cyst	9.5%
221	Angioedema	9.5%
222	Onchocerciasis	9.4%
223	Familial Hypophosphatemic Rickets	9.4%
224	Myxedema	9.4%
225	Chromoblastomycosis	9.4%
226	Dermatophytosis	9.4%
227	Sporotrichosis	9.4%
228	Tinea	9.4%
229	Tinea Versicolor	9.4%
230	Trichophytosis	9.4%
231	Hyalohyphomycosis	9.4%
232	Acute Generalized Exanthematous Pustulosis	9.3%
233	Lichen Planus, Oral	9.1%
234	Hyperlipoproteinemia Type IV	9.1%
235	Hyperlipoproteinemia Type V	9.1%
236	Noonan Syndrome	9%
237	Smith-Lemli-Opitz Syndrome	8.8%
238	Galactosemias	8.8%
239	Urea Cycle Disorders, Inborn	8.8%
240	Tyrosinemias	8.8%
241	Lactose Intolerance	8.6%
242	Gaucher Disease	8.5%
243	Hypolipoproteinemias	8.4%
244	Warts	8.4%
245	Marfan Syndrome	8.2%
246	Candidiasis, Chronic Mucocutaneous	8.2%
247	Cutaneous Candidiasis	8.2%
248	Osteochondritis	8.2%
249	Polymyalgia Rheumatica	8.2%
250	Erysipelas	8.2%
251	Serum Sickness	8.2%
252	Staphylococcal Skin Infections	8.2%
253	Osteomalacia	8.2%
254	Erythrasma	8.2%
255	Carcinoma, Lobular	8.2%
256	Arthritis, Psoriatic	8.2%
257	Collagen Diseases	8.1%
258	Glycogen storage disease type II	8%
259	Giant Cell Arteritis	8%
260	Temporal Arteritis	8%
261	Hyperphosphaturia	8%
262	Acidosis	7.9%
263	Alkalosis	7.9%
264	Amyloidosis	7.9%
265	Calcinosis	7.9%
266	Hyperglycemia	7.9%
267	Hyperinsulinism	7.9%
268	Hyperkalemia	7.9%
269	Hypernatremia	7.9%
270	Hypoglycemia	7.9%
271	Hypokalemia	7.9%
272	Hyponatremia	7.9%
273	Xanthomatosis	7.9%
274	Hypophosphatemia	7.9%
275	Metabolic acidosis	7.9%
276	Dyslipidemias	7.9%
277	Iron Overload	7.9%
278	Xanthoma	7.9%
279	Diabetic Ketoacidosis	7.7%
280	Leishmaniasis, Cutaneous	7.7%
281	Eczema Herpeticum	7.7%
282	Hyperlipidemia, Familial Combined	7.7%
283	Fusariosis	7.7%
284	Mitochondrial Encephalomyopathies	7.7%
285	Tay-Sachs Disease	7.6%
286	Congenital Hyperinsulinism	7.5%
287	Niemann-Pick Disease, Type C	7.3%
288	Hyperlipoproteinemia Type III	7.3%
289	Mucopolysaccharidosis II	7.3%
290	Rheumatoid Arthritis	7.2%
291	Juvenile arthritis	7.2%
292	Amyloid Neuropathies, Familial	7.1%
293	Hypoalphalipoproteinemias	7%
294	Lupus Nephritis	7%
295	Fabry Disease	6.9%
296	Nutrition Disorders	6.9%
297	Diabetes Mellitus	6.9%
298	Hereditary Angioedema Type III	6.8%
299	Hereditary Angioedema Types I and II	6.8%
300	Angioedemas, Hereditary	6.8%
301	Adrenoleukodystrophy	6.8%
302	Epidermodysplasia Verruciformis	6.8%
303	Herpes Labialis	6.8%
304	Diabetic Foot	6.7%
305	Dehydration	6.7%
306	Water Intoxication	6.7%
307	Werner Syndrome	6.7%
308	Staphylococcal Scalded Skin Syndrome	6.7%
309	Achlorhydria	6.6%
310	Amino Acid Metabolism, Inborn Errors	6.6%
311	Bloom Syndrome	6.6%
312	Carbohydrate Metabolism, Inborn Errors	6.6%
313	Metal Metabolism, Inborn Errors	6.6%
314	Osteoporosis	6.6%
315	Progeria	6.6%
316	Lysosomal Storage Diseases	6.6%
317	Bone Demineralization, Pathologic	6.6%
318	Cytochrome-c Oxidase Deficiency	6.6%
319	Peroxisomal Disorders	6.6%
320	Post-Traumatic Osteoporosis	6.6%
321	Blastomycosis	6.6%
322	Celiac Disease	6.6%
323	Sprue, Tropical	6.6%
324	Steatorrhea	6.6%
325	Sprue	6.6%
326	Renal tubular acidosis	6.5%
327	Laryngomalacia	6.4%
328	Pectus carinatum	6.4%
329	MELAS Syndrome	6.3%
330	Zellweger Syndrome	6.3%
331	Nesidioblastosis	6.1%
332	Peutz-Jeghers Syndrome	6.1%
333	Rhinoscleroma	6.1%
334	Condylomata Acuminata	6%
335	Furunculosis	6%
336	furuncle	6%
337	Neuronal Ceroid-Lipofuscinoses	6%
338	Renal Osteodystrophy	6%
339	Renal rickets	6%
340	carbuncle	6%
341	Impetigo	5.9%
342	Acidosis, Lactic	5.9%
343	Calciphylaxis	5.9%
344	Hemosiderosis	5.9%
345	Ketosis	5.9%
346	Ketonuria	5.9%
347	Ketoacidosis	5.9%
348	Ketonemia	5.9%
349	Vascular calcification	5.9%
350	Hepatolenticular Degeneration	5.9%
351	HIV Wasting Syndrome	5.9%
352	Refsum Disease	5.8%
353	Mitochondrial Myopathies	5.7%
354	Myelinolysis, Central Pontine	5.7%
355	Glycosuria	5.7%
356	Reye Syndrome	5.7%
357	Hepatic Encephalopathy	5.6%
358	Rheumatoid Nodule	5.6%
359	Glycosuria, Renal	5.3%
360	Wernicke Encephalopathy	5.2%
361	Acidosis, Respiratory	4.9%
362	Alkalosis, Respiratory	4.9%
363	Felty Syndrome	4.9%
364	Bronchomalacia	4.9%
365	Tracheomalacia	4.9%
366	Alkaptonuria	4.9%
367	Fanconi Anemia	4.9%
368	Glycogen Storage Disease	4.9%
369	Hypercholesterolemia	4.9%
370	Hyperlipoproteinemias	4.9%
371	Hypertriglyceridemia	4.9%
372	Hypophosphatasia	4.9%
373	Insulin Resistance	4.9%
374	Osteoporosis, Postmenopausal	4.9%
375	Propionic acidemia	4.9%
376	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
377	Cystinosis	4.9%
378	Kearns-Sayre syndrome	4.5%
379	Rheumatoid Vasculitis	4.4%
380	Friedreich Ataxia	4.4%
381	Gestational Diabetes	4.3%
382	Latent Autoimmune Diabetes in Adults	4.3%
383	Diabetes Mellitus, Experimental	4.3%
384	Nephrocalcinosis	4.2%
385	Tetany	4.2%
386	Cerebral Amyloid Angiopathy	4.2%
387	Glycogen Storage Disease Type I	4.1%
388	Glycogen Storage Disease Type V	4.1%
389	Canavan Disease	4.1%
390	Alexander Disease	4.1%
391	Child Nutrition Disorders	4%
392	Hypervitaminosis A	4%
393	Infant Nutrition Disorders	4%
394	Malnutrition	4%
395	Kernicterus	4%
396	Cockayne Syndrome	4%
397	Sicca Syndrome	3.9%
398	Sjogren's Syndrome	3.9%
399	Familial Periodic Paralysis	3.7%
400	Primary amyloidosis	3.7%
401	Lupus Vasculitis, Central Nervous System	3.7%
402	Renal Aminoacidurias	3.7%
403	Fanconi Syndrome	3.7%
404	Pseudohypoaldosteronism	3.7%
405	Liddle Syndrome	3.7%
406	Ataxia Telangiectasia	3.7%
407	Optic Atrophy, Hereditary, Leber	3.6%
408	Gout	3.3%
409	Amyotrophic Lateral Sclerosis	3.3%
410	Antley-Bixler Syndrome Phenotype	3.3%
411	Hypokalemic periodic paralysis	3.1%
412	Frontotemporal dementia	3%
413	Cystinuria	3%
414	Arthritis, Gouty	2.7%
415	Deficiency Diseases	2.6%
416	Starvation	2.6%
417	Refeeding Syndrome	2.6%
418	Kwashiorkor	2%
419	Magnesium Deficiency	2%
420	Potassium Deficiency	2%
421	Protein Deficiency	2%
422	Avitaminosis	2%
423	Ascorbic Acid Deficiency	1.6%
424	Vitamin A Deficiency	1.6%
425	Vitamin D Deficiency	1.6%
426	Vitamin E Deficiency	1.6%
427	Marasmus	1.6%
428	Obesity	1.6%
429	Folic Acid Deficiency	1.5%
430	Pellagra	1.5%
431	Thiamine Deficiency	1.5%
432	Vitamin B 12 Deficiency	1.5%
433	Vitamin B 6 Deficiency	1.5%
434	Pyridoxine Deficiency	1.5%
435	Beriberi	1.4%
436	Obesity, Abdominal	1.4%
437	Pediatric Obesity	1.2%
438	Vitamin K Deficiency	1.2%
439	Anemia, Pernicious	1.2%
440	Prader-Willi Syndrome	1.1%
441	Scurvy	1.1%
442	Subacute Combined Degeneration	0.8%

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