MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Familial Hypophosphatemic Rickets

(UMLS:C3536983)

Definition:: A hereditary disorder characterized by HYPOPHOSPHATEMIA; RICKETS; OSTEOMALACIA; renal defects in phosphate reabsorption and vitamin D metabolism; and growth retardation. Autosomal and X-linked dominant and recessive variants have been reported.
UMLS ID:: C3536983
MeSH ID:: D053098

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.198.816.875.500

Classification 2:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.815.647.500

Classification 3:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.815.647.500

Classification 4:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.618.544.500|C16.320.565.861.647.500

Classification 5:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.104.816.875.500|C18.452.174.845.875.500|C18.452.648.618.544.500|C18.452.648.861.647.500|C18.452.750.400.500.500|C18.452.750.400.750.500|C18.654.521.500.133.770.734.875.500

Synonym(s)

Familial Hypophosphatemic Rickets

Calcitriol receptor defect

End organ unresponsiveness to 1,25-dihydroxycholecalciferol

Familial hypophosphataemic bone disease

Familial hypophosphataemic rickets

Familial hypophosphatemic bone disease

Familial hypophosphatemic rickets

Familial vitamin D-resistant rickets

Hereditary 1,25 Dihydroxyvitamin D-Resistant Rickets with Abnormal Vitamin D Receptor without Alopecia

10.

Hereditary hypophosphataemic rickets

11.

Type 2 vitamin D-dependent rickets

12.

Vitamin D Dependent Rickets 2b

13.

Vitamin D Receptor Signaling Defect Rickets

14.

Vitamin D Resistant Rickets

15.

Vitamin D-dependent rickets type II

16.

Vitamin D-dependent rickets, type 2

17.

familial hypophosphatemia

18.

hypophosphataemic rickets

19.

hypophosphatemia rickets

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Calcitriol	View details 1517380 1660098 6688127 8004848	CTD
2	Ergocalciferols	9430241	CTD
3	Phosphates	View details 1517380 1660098 8004848 9430241 18775977	CTD
4	alfacalcidol	18775977	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Pseudohypoparathyroidism	40.8%
2	Renal Osteodystrophy	30%
3	Renal rickets	30%
4	Brain Diseases, Metabolic, Inborn	29.8%
5	Renal tubular acidosis	29.7%
6	Leigh Disease	29.6%
7	Wasting Syndrome	28.6%
8	Glycosuria, Renal	28.3%
9	Osteomalacia	28.2%
10	Zellweger Syndrome	28%
11	Menkes Kinky Hair Syndrome	27.9%
12	Smith-Lemli-Opitz Syndrome	27.5%
13	Galactosemias	26.6%
14	Urea Cycle Disorders, Inborn	26.6%
15	Tyrosinemias	26.6%
16	Hepatolenticular Degeneration	26.5%
17	Renal Aminoacidurias	26%
18	Fanconi Syndrome	26%
19	Pseudohypoaldosteronism	26%
20	Liddle Syndrome	26%
21	Adrenoleukodystrophy	25.9%
22	Carbamoyl-Phosphate Synthase I Deficiency Disease	24.5%
23	Hyperhomocysteinemia	24.3%
24	Hypercalcemia	23.7%
25	Hypocalcemia	23.7%
26	Milk-Alkali Syndrome	23.7%
27	Amino Acid Metabolism, Inborn Errors	23.3%
28	Carbohydrate Metabolism, Inborn Errors	23.3%
29	Progeria	23.3%
30	Lysosomal Storage Diseases	23.3%
31	Peroxisomal Disorders	23.3%
32	Refsum Disease	22.5%
33	Glycogen storage disease type II	22.2%
34	Homocystinuria	21.8%
35	Lactose Intolerance	21.6%
36	Acid-Base Imbalance	20.9%
37	Iron Metabolism Disorders	20.9%
38	Water-Electrolyte Imbalance	20.9%
39	Lipid Metabolism Disorders	20.9%
40	Mitochondrial Diseases	20.9%
41	Glucose Metabolism Disorders	20.9%
42	Hyperphosphaturia	20.4%
43	Lipodystrophy	20.1%
44	Brain Diseases, Metabolic	19.5%
45	Hypophosphatasia	19.3%
46	Amyloid Neuropathies, Familial	19%
47	Hypolipoproteinemias	18.9%
48	Familial Hypophosphatemic Rickets	18.8%
49	Cytochrome-c Oxidase Deficiency	18.7%
50	Gaucher Disease	18.6%
51	Fabry Disease	18.3%
52	Familial Periodic Paralysis	18%
53	Calcium Metabolism Disorders	17.6%
54	Hyperlipoproteinemia Type IV	17.6%
55	Hyperlipoproteinemia Type V	17.6%
56	Cystinuria	17.2%
57	Osteoporosis	17%
58	Bone Demineralization, Pathologic	17%
59	Post-Traumatic Osteoporosis	17%
60	Werner Syndrome	17%
61	Hyperlipidemia, Familial Combined	16.9%
62	Rickets	16.7%
63	MELAS Syndrome	16.6%
64	Osteopenia	16.5%
65	Hyperlipoproteinemia Type III	15.8%
66	Mucopolysaccharidosis II	15.8%
67	Neuronal Ceroid-Lipofuscinoses	15.7%
68	Cockayne Syndrome	15.5%
69	Albinism	15.4%
70	Metal Metabolism, Inborn Errors	15.3%
71	Ichthyosis, X-Linked	15.2%
72	Mucopolysaccharidosis III	15.1%
73	Nephrocalcinosis	14.9%
74	Mitochondrial Encephalomyopathies	14.6%
75	Niemann-Pick Disease, Type C	14.5%
76	Phosphorus Metabolism Disorders	14.3%
77	Sjogren-Larsson Syndrome	14%
78	Calcinosis	14%
79	Alkaptonuria	13.9%
80	Glycogen Storage Disease	13.9%
81	Propionic acidemia	13.9%
82	Dihydropyrimidine Dehydrogenase Deficiency	13.9%
83	Cystinosis	13.9%
84	Glycosuria	13.5%
85	Tay-Sachs Disease	13.4%
86	Gout	13.3%
87	Congenital Hyperinsulinism	13.1%
88	Antley-Bixler Syndrome Phenotype	13%
89	HIV Wasting Syndrome	12.8%
90	Nutrition Disorders	12.7%
91	Ataxia Telangiectasia	12.6%
92	Porphyrias, Hepatic	12.5%
93	Hypoalphalipoproteinemias	12.5%
94	Fanconi Anemia	12.4%
95	Bloom Syndrome	11.9%
96	Canavan Disease	11.8%
97	Alexander Disease	11.8%
98	Hypokalemic periodic paralysis	11.7%
99	Acidosis	11.5%
100	Alkalosis	11.5%
101	Amyloidosis	11.5%
102	Hyperglycemia	11.5%
103	Hyperinsulinism	11.5%
104	Hyperkalemia	11.5%
105	Hypernatremia	11.5%
106	Hypoglycemia	11.5%
107	Hypokalemia	11.5%
108	Hyponatremia	11.5%
109	Xanthomatosis	11.5%
110	Metabolic acidosis	11.5%
111	Dyslipidemias	11.5%
112	Iron Overload	11.5%
113	Xanthoma	11.5%
114	Mitochondrial Myopathies	11%
115	Optic Atrophy, Hereditary, Leber	10.9%
116	Diabetes Mellitus	10.9%
117	Xeroderma Pigmentosum	10.9%
118	Dehydration	10.8%
119	Lipomatosis	10.8%
120	Water Intoxication	10.8%
121	Achlorhydria	10.7%
122	Celiac Disease	10.7%
123	Sprue, Tropical	10.7%
124	Steatorrhea	10.7%
125	Sprue	10.7%
126	Wernicke Encephalopathy	10.7%
127	Friedreich Ataxia	10.5%
128	Anuria	10.5%
129	Nephrolithiasis	10.5%
130	Osteoporosis, Postmenopausal	10.1%
131	Myelinolysis, Central Pontine	10.1%
132	Reye Syndrome	10%
133	Hepatic Encephalopathy	10%
134	HIV-Associated Lipodystrophy Syndrome	9.9%
135	Diabetic Ketoacidosis	9.9%
136	Kearns-Sayre syndrome	9.7%
137	Child Nutrition Disorders	9.6%
138	Hypervitaminosis A	9.6%
139	Infant Nutrition Disorders	9.6%
140	Necrobiosis Lipoidica Diabeticorum	9.4%
141	Kernicterus	9.3%
142	Glycogen Storage Disease Type I	9.2%
143	Glycogen Storage Disease Type V	9.2%
144	Tuberculosis, Renal	9%
145	Arthritis, Gouty	8.6%
146	Nesidioblastosis	8.4%
147	Polycystic Kidney Diseases	8.3%
148	Calciphylaxis	8.3%
149	Vascular calcification	8.3%
150	Hydronephrosis	8.2%
151	Hyperoxaluria	8.2%
152	Kidney Cortex Necrosis	8.2%
153	Kidney Papillary Necrosis	8.2%
154	Nephritis	8.2%
155	Nephrosclerosis	8.2%
156	Nephrosis	8.2%
157	Perinephritis	8.2%
158	Kidney Failure	8.2%
159	Uremia	8.2%
160	Oxalosis	8.2%
161	Renal Insufficiency	8.2%
162	Kidney Neoplasm	8%
163	Multiple Epiphyseal Dysplasia	7.9%
164	Osteochondrodysplasias	7.9%
165	Hypophosphatemia	7.8%
166	Diabetes Insipidus	7.8%
167	Hepatorenal Syndrome	7.8%
168	Diabetic Nephropathy	7.7%
169	Renal hypertension	7.7%
170	Renal Artery Obstruction	7.7%
171	Renal Artery Stenosis	7.7%
172	Aicardi's syndrome	7.6%
173	Dwarfism	7.5%
174	Variegate Porphyria	7.4%
175	Acute intermittent porphyria	7.4%
176	Porphyria Cutanea Tarda	7.4%
177	Nail-Patella Syndrome	7.4%
178	Cystic Fibrosis	7.3%
179	Marfan Syndrome	7.3%
180	Tetany	7.2%
181	Starvation	7.2%
182	Refeeding Syndrome	7.2%
183	Multicystic Dysplastic Kidney	7.2%
184	Prader-Willi Syndrome	7%
185	Gestational Diabetes	6.9%
186	Kidney Calculi	6.9%
187	CHARGE Syndrome	6.9%
188	Acidosis, Lactic	6.8%
189	Hemosiderosis	6.8%
190	Ketosis	6.8%
191	Ketonuria	6.8%
192	Ketoacidosis	6.8%
193	Ketonemia	6.8%
194	AIDS-Associated Nephropathy	6.8%
195	Osteogenesis Imperfecta	6.7%
196	Urinary Bladder Diseases	6.7%
197	Ureteral Diseases	6.7%
198	Urethral Diseases	6.7%
199	Urination Disorders	6.7%
200	Urolithiasis	6.7%
201	Malnutrition	6.6%
202	Urogenital Abnormalities	6.6%
203	Kartagener Syndrome	6.5%
204	Nephroblastoma	6.5%
205	Ureterolithiasis	6.5%
206	Acidosis, Respiratory	6.4%
207	Adiposis Dolorosa	6.4%
208	Alkalosis, Respiratory	6.4%
209	Insulin Resistance	6.4%
210	Muscular Dystrophy	6.3%
211	Urinary tract infection	6.3%
212	Muscular Dystrophy, Duchenne	6.3%
213	Neoplastic Syndromes, Hereditary	6.3%
214	Pelger-Huet Anomaly	6.2%
215	Myasthenic Syndromes, Congenital	6.2%
216	Bladder Exstrophy	6.2%
217	Epispadias	6.2%
218	Magnesium Deficiency	6.1%
219	Potassium Deficiency	6.1%
220	Protein Deficiency	6.1%
221	CREST Syndrome	6%
222	Latent Autoimmune Diabetes in Adults	6%
223	Diabetes Mellitus, Experimental	6%
224	Anemia, Sickle Cell	6%
225	Thalassemia	6%
226	Alstrom Syndrome	6%
227	Cerebral Amyloid Angiopathy	5.9%
228	Rubinstein-Taybi Syndrome	5.9%
229	Kallmann Syndrome	5.8%
230	Myotonic Dystrophy	5.7%
231	Pyelonephritis	5.7%
232	Ascorbic Acid Deficiency	5.7%
233	Vitamin A Deficiency	5.7%
234	Vitamin E Deficiency	5.7%
235	Holoprosencephaly	5.7%
236	Primary amyloidosis	5.6%
237	Fragile X Syndrome	5.6%
238	Autoimmune Lymphoproliferative Syndrome	5.5%
239	Angioedemas, Hereditary	5.4%
240	Wiskott-Aldrich Syndrome	5.3%
241	Beckwith-Wiedemann Syndrome	5.3%
242	Wolf-Hirschhorn Syndrome	5.3%
243	Amyotrophic Lateral Sclerosis	5.3%
244	Polycystic Kidney, Autosomal Dominant	5.3%
245	Bladder neck obstruction	5.2%
246	Congenital Hypothyroidism	5.1%
247	Smith-Magenis syndrome	5%
248	Cri-du-Chat Syndrome	5%
249	Down Syndrome	5%
250	Trisomy 21	5%
251	Vitamin K Deficiency	5%
252	Tuberous Sclerosis	5%
253	Fetal Diseases	4.9%
254	Glomerulonephritis	4.9%
255	Nephritis, Interstitial	4.9%
256	Lipoid nephrosis	4.9%
257	Nephrotic Syndrome	4.9%
258	Pyelitis	4.9%
259	Pyonephrosis	4.9%
260	Nephrogenic Diabetes Insipidus	4.9%
261	Congenital Nephrogenic Diabetes Insipidus	4.9%
262	Acute kidney injury	4.9%
263	Ureteral Calculi	4.9%
264	Pyelocystitis	4.8%
265	Ectodermal Dysplasia	4.7%
266	Aplasia Cutis Congenita	4.7%
267	Azotemia	4.6%
268	Hypertension, Renovascular	4.6%
269	Hypercholesterolemia	4.5%
270	Hyperlipoproteinemias	4.5%
271	Hypertriglyceridemia	4.5%
272	Mesoblastic Nephroma	4.5%
273	Renal Cell Carcinoma	4.5%
274	Papillary Renal Cell Carcinoma	4.5%
275	Basal Cell Nevus Syndrome	4.4%
276	Hemolytic-Uremic Syndrome	4.3%
277	Urinary Bladder Fistula	4.2%
278	Bladder Neoplasm	4.2%
279	Ureteral Neoplasms	4.2%
280	Urethral Neoplasms	4.2%
281	Deformity	4.2%
282	Denys-Drash Syndrome	4.2%
283	Obesity	4.2%
284	Osteoarthropathy, Secondary Hypertrophic	4.1%
285	Platybasia	4.1%
286	Pectus carinatum	4.1%
287	Kwashiorkor	4%
288	Williams Syndrome	4%
289	Meconium Aspiration Syndrome	3.9%
290	Osteochondritis	3.9%
291	Retinal Dysplasia	3.8%
292	Rett Syndrome	3.8%
293	Aniridia	3.8%
294	Epidermolysis Bullosa	3.8%
295	Hypospadias	3.8%
296	Arthrogryposis	3.8%
297	Cystitis	3.7%
298	Ureteral obstruction	3.7%
299	Ureterocele	3.7%
300	Urethral Obstruction	3.7%
301	Urethritis	3.7%
302	Vesico-Ureteral Reflux	3.7%
303	Urinary Retention	3.7%
304	Primary Ciliary Dyskinesia	3.7%
305	Frontotemporal dementia	3.7%
306	Deficiency Diseases	3.7%
307	Familial Mediterranean Fever	3.7%
308	Pectus excavatum	3.6%
309	Sickle Cell Trait	3.6%
310	Marasmus	3.5%
311	Myotonia Congenita	3.5%
312	Welander Distal Myopathy	3.5%
313	Horseshoe Kidney	3.5%
314	Bacteriuria	3.5%
315	Hematuria	3.5%
316	Oliguria	3.5%
317	Polyuria	3.5%
318	Proteinuria	3.5%
319	Pyuria	3.5%
320	Urinary Calculi	3.5%
321	Folic Acid Deficiency	3.5%
322	Pellagra	3.5%
323	Thiamine Deficiency	3.5%
324	Vitamin B 12 Deficiency	3.5%
325	Vitamin B 6 Deficiency	3.5%
326	Pyridoxine Deficiency	3.5%
327	Cystocele	3.5%
328	Urinary Incontinence	3.5%
329	Pseudoxanthoma Elasticum	3.4%
330	Bone Diseases, Developmental	3.3%
331	Hyperostosis	3.3%
332	Osteitis	3.3%
333	Osteitis Deformans	3.3%
334	Osteochondrosis	3.3%
335	Spinal Diseases	3.3%
336	Hermaphroditism	3.3%
337	Disorders of Sex Development	3.3%
338	Balkan Nephropathy	3.3%
339	Focal glomerulosclerosis	3.3%
340	Kidney Failure, Chronic	3.3%
341	Enuresis	3.3%
342	Acute Chest Syndrome	3.2%
343	Cutis Laxa	3.2%
344	Retinitis Pigmentosa	3.2%
345	Pigmentary retinopathy	3.2%
346	Gigantism	3.2%
347	Spinal Neoplasms	3.2%
348	Spondylitis	3.2%
349	Porokeratosis	3.2%
350	Keratoderma, Palmoplantar	3.2%
351	Chronic granulomatous disease	3.2%
352	Bone Diseases, Endocrine	3.1%
353	Glomerulonephritis, Membranoproliferative	3.1%
354	Bone Diseases, Infectious	3.1%
355	Bone neoplasms	3.1%
356	Bone Resorption	3.1%
357	Aseptic Necrosis of Bone	3.1%
358	Duane Retraction Syndrome	3%
359	Scurvy	3%
360	Peutz-Jeghers Syndrome	3%
361	Thrombasthenia	3%
362	Antithrombin III Deficiency	3%
363	Protein C Deficiency	3%
364	Afibrinogenemia	3%
365	Dystonia Musculorum Deformans	3%
366	Factor VII Deficiency	3%
367	Factor X Deficiency	3%
368	Factor XII Deficiency	3%
369	Hemophilia A	3%
370	Activated Protein C Resistance	3%
371	Factor II deficiency	3%
372	Factor VIII Deficiency	3%
373	Factor V deficiency	3%
374	Factor XI Deficiency	3%
375	Hypoprothrombinemias	3%
376	Klippel-Feil Syndrome	3%
377	Synostosis	3%
378	Lafora Disease	3%
379	Unverricht-Lundborg Syndrome	3%
380	Anemia, Diamond-Blackfan	3%
381	Chorioamnionitis	3%
382	Anti-Glomerular Basement Membrane Disease	2.9%
383	Lupus Nephritis	2.9%
384	Turner Syndrome	2.9%
385	Atypical Hemolytic Uremic Syndrome	2.9%
386	Multiple Endocrine Neoplasia	2.9%
387	Dermatitis, Atopic	2.8%
388	Xeroderma	2.8%
389	Mobius Syndrome	2.8%
390	Behcet Syndrome	2.7%
391	Acrocephalosyndactylia	2.7%
392	Craniosynostosis	2.6%
393	Syndactyly	2.6%
394	Brachycephaly	2.6%
395	Infertility	2.6%
396	Obesity, Abdominal	2.6%
397	Eosinophilic Granuloma	2.5%
398	Huntington Disease	2.5%
399	Hyperkeratosis, Epidermolytic	2.5%
400	Cryptorchidism	2.4%
401	Pediatric Obesity	2.4%
402	Fetal Growth Retardation	2.4%
403	Urologic Neoplasms	2.4%
404	Fetal Hypoxia	2.4%
405	Fetal Alcohol Spectrum Disorders	2.4%
406	Classical Lissencephalies and Subcortical Band Heterotopias	2.3%
407	Beriberi	2.3%
408	Klinefelter Syndrome	2.3%
409	Sexually Transmitted Diseases	2.3%
410	Adenomatous Polyposis Coli	2.3%
411	Genital Herpes	2.3%
412	Charcot-Marie-Tooth Disease	2.3%
413	Abdominal Cramps	2.2%
414	Abnormalities, Drug-Induced	2.2%
415	Amniotic Band Syndrome	2.2%
416	Asphyxia Neonatorum	2.2%
417	Infant, Premature, Diseases	2.2%
418	Situs Inversus	2.2%
419	Infantile Colic	2.2%
420	Urethral Stenosis	2.2%
421	Urethral stricture	2.2%
422	Avitaminosis	2.2%
423	Limb Deformities, Congenital	2.2%
424	Craniofacial Abnormalities	2.2%
425	Anemia, Pernicious	2.2%
426	Craniofacial Dysostosis	2.1%
427	Fasciitis	2.1%
428	Foot Deformities	2.1%
429	Genital Diseases, Male	2.1%
430	Arthropathy	2.1%
431	Maxillofacial Abnormalities	2.1%
432	Eye Abnormalities	2.1%
433	Cardiovascular Abnormalities	2.1%
434	Hydrops Fetalis	2.1%
435	Contracture	2.1%
436	Skin Abnormalities	2.1%
437	Fasciitis, Plantar	2.1%
438	Lymphatic Abnormalities	2.1%
439	Congenital Microtia	2.1%
440	Albuminuria	2.1%
441	Hemoglobinuria	2.1%
442	Urge Incontinence	2.1%
443	Anemia, Neonatal	2.1%
444	Persistent Fetal Circulation Syndrome	2.1%
445	Congenital diaphragmatic hernia	2.1%
446	Umbilical hernia	2.1%
447	Pregnancy Complications	2%
448	Gastroschisis	2%
449	Metabolic Diseases	2%
450	Jaw Diseases	2%
451	Cartilage Diseases	2%
452	Foot Diseases	2%
453	Myopathy	2%
454	Rheumatism	2%
455	Chondromalacia	2%
456	Jaw Abnormalities	2%
457	Neonatal Abstinence Syndrome	1.9%
458	Diurnal Enuresis	1.9%
459	Fibromyalgia	1.9%
460	Genital Neoplasms, Male	1.9%
461	Polymyalgia Rheumatica	1.9%
462	Metatarsalgia	1.9%
463	Congenital nystagmus	1.9%
464	Toxoplasmosis, Congenital	1.9%
465	Syphilis, Congenital	1.9%
466	Discitis	1.9%
467	Papillon-Lefevre Disease	1.9%
468	Gonadal Dysgenesis	1.8%
469	Adrenogenital Syndrome	1.8%
470	Ovotesticular Disorders of Sex Development	1.8%
471	Ainhum	1.8%
472	Dysostoses	1.8%
473	Spinal Stenosis	1.8%
474	Spondylosis	1.8%
475	Intervertebral Disc Degeneration	1.8%
476	Hyperandrogenism	1.8%
477	Vesicovaginal Fistula	1.8%
478	Laryngomalacia	1.8%
479	Subacute Combined Degeneration	1.8%
480	Tuberculosis, Spinal	1.8%
481	Poland Syndrome	1.7%
482	Osteomyelitis	1.7%
483	Periostitis	1.7%
484	Alveolar Bone Loss	1.7%
485	Femur Head Necrosis	1.7%
486	Osteolysis	1.7%
487	Anencephaly	1.7%
488	Abnormalities, Radiation-Induced	1.7%
489	Multiple Endocrine Neoplasia Type 1	1.7%
490	Osteoarthritis, Spine	1.7%
491	Endometriosis	1.7%
492	Uterine Diseases	1.7%
493	Vaginal Diseases	1.7%
494	Vulvar Diseases	1.7%
495	Endometrioma	1.7%
496	Temporomandibular Joint Disorders	1.6%
497	Dural Arteriovenous Fistula	1.6%
498	Dextrocardia	1.6%
499	Ophthalmia Neonatorum	1.6%
500	Acromegaly	1.6%
501	Joint Tuberculosis	1.6%
502	Tuberculosis, Osteoarticular	1.6%
503	Bone Tuberculosis	1.6%
504	Uterine Neoplasms	1.6%
505	Vaginal Neoplasms	1.6%
506	Vulvar Neoplasms	1.6%
507	Uterine Cancer	1.6%
508	Genital Neoplasms, Female	1.5%
509	Cleft Palate	1.5%
510	Noonan Syndrome	1.5%
511	Prognathism	1.5%
512	Ischemic contracture	1.5%
513	Penile Neoplasms	1.5%
514	Prostatic Neoplasms	1.5%
515	Rheumatic Fever	1.5%
516	Talipes	1.5%
517	Microcephaly	1.5%
518	Macrocephaly	1.5%
519	Vitamin D Deficiency	1.5%
520	Scimitar Syndrome	1.4%
521	Rheumatoid Arthritis	1.4%
522	Juvenile arthritis	1.4%
523	Uterine Inversion	1.4%
524	Endometritis	1.4%
525	Temporomandibular Joint Dysfunction Syndrome	1.3%
526	Dyspareunia	1.3%
527	Mandibulofacial Dysostosis	1.3%
528	Uterine Rupture	1.3%
529	Fallopian Tube Neoplasms	1.3%
530	Amelia	1.3%
531	Arachnodactyly	1.3%
532	Ectromelia	1.3%
533	Hemimelia	1.3%
534	Phocomelia	1.3%
535	Sirenomelia	1.3%
536	Polydactyly	1.3%
537	Brachydactyly	1.3%
538	Plagiocephaly	1.3%
539	Lower Extremity Deformities, Congenital	1.3%
540	Upper Extremity Deformities, Congenital	1.3%
541	Micrognathism	1.2%
542	Pierre Robin Syndrome	1.2%
543	Prune Belly Syndrome	1.2%
544	Twins, Conjoined	1.2%
545	Waardenburg Syndrome	1.2%
546	Ankylosing spondylitis	1.2%
547	Retrognathia	1.2%
548	Anophthalmos	1.1%
549	Anus, Imperforate	1.1%
550	Hydranencephaly	1.1%
551	Microphthalmos	1.1%
552	Neural Tube Defects	1.1%
553	Paralysis, Obstetric	1.1%
554	Retinopathy of Prematurity	1.1%
555	Tethered Cord Syndrome	1.1%
556	Iniencephaly	1.1%
557	Craniorachischisis	1.1%
558	Exencephaly	1.1%
559	Septo-Optic Dysplasia	1.1%
560	Cortical Dysplasia	1.1%
561	Malformations of Cortical Development	1.1%
562	Anorectal Malformations	1.1%
563	Arthritis, Psoriatic	1.1%
564	Hip Contracture	1.1%
565	Periarthritis	1.1%
566	Bronchopulmonary Dysplasia	1.1%
567	ovarian neoplasm	1.1%
568	Arthritis	1.1%
569	Bursitis	1.1%
570	Epididymitis	1.1%
571	Joint Instability	1.1%
572	Myofascial Pain Syndromes	1.1%
573	Penile Diseases	1.1%
574	Prostatic Diseases	1.1%
575	Rhabdomyolysis	1.1%
576	Spermatic Cord Torsion	1.1%
577	Synovitis	1.1%
578	Joint laxity	1.1%
579	Hemospermia	1.1%
580	Polyarthritis	1.1%
581	Frozen shoulder	1.1%
582	Patellofemoral Pain Syndrome	1.1%
583	Testicular Hydrocele	1.1%
584	Bronchomalacia	1.1%
585	Tracheomalacia	1.1%
586	Chondrodysplasia Punctata	1.1%
587	Enchondromatosis	1.1%
588	Lordosis	1.1%
589	Osteosclerosis	1.1%
590	Spondylolysis	1.1%
591	kyphosis	1.1%
592	Kashin-Beck Disease	1.1%
593	Porencephaly	1.1%
594	Blepharophimosis	1.1%
595	Laryngostenosis	1.1%
596	Mouth Abnormalities	1.1%
597	Respiratory Distress Syndrome, Newborn	1.1%
598	Esophageal Atresia	1.1%
599	Intestinal Atresia	1.1%
600	Acrodermatitis	1.1%
601	Lymphangiectasis, Intestinal	1.1%
602	Gianotti-Crosti Syndrome	1.1%
603	Polyhydramnios	1%
604	Obstetric Labor Complications	1%
605	Ectopic Pregnancy	1%
606	Pregnancy, Prolonged	1%
607	Puerperal Disorders	1%
608	Oligohydramnios	1%
609	Prenatal Injuries	1%
610	Compartment syndromes	1%
611	Maxillary Diseases	1%
612	Tendinitis	1%
613	Testicular Diseases	1%
614	Varicocele	1%
615	Tendinopathy	1%
616	Hemarthrosis	1%
617	Myositis	1%
618	Spermatocele	1%
619	Tietze's Syndrome	1%
620	Isaacs syndrome	1%
621	Myotonic Disorders	1%
622	Abruptio Placentae	1%
623	Placenta Accreta	1%
624	Spondylarthropathies	1%
625	Salpingitis	1%
626	Vulvovaginitis	1%
627	Choanal Atresia	1%
628	Tracheobronchomegaly	1%
629	Laryngocele	1%
630	Choledochal Cyst	1%
631	Central Nervous System Cysts	1%
632	Goldenhar Syndrome	1%
633	Dandy-Walker Syndrome	1%
634	Leukomalacia, Periventricular	1%
635	POEMS Syndrome	1%
636	Congenital clubfoot	1%
637	Vertical Talus	1%
638	Pregnancy Complications, Cardiovascular	1%
639	Pregnancy Complications, Neoplastic	1%
640	Pregnancy Complications, Hematologic	1%
641	Pregnancy Complications, Infectious	1%
642	Palatal Neoplasms	1%
643	Fetal Death	1%
644	Perinatal death	1%
645	Morning Sickness	1%
646	Medial Tibial Stress Syndrome	1%
647	Muscle Cramp	1%
648	Eosinophilia-Myalgia Syndrome	1%
649	Puerperal Infection	1%
650	Muscle Rigidity	1%
651	Muscle Spasticity	1%
652	Cogwheel Rigidity	1%
653	Nuchal Rigidity	1%
654	Postpartum Hemorrhage	1%
655	Mastoiditis	1%
656	Oophoritis	1%
657	Petrositis	1%
658	Endometrial Neoplasms	1%
659	Arthritis, Reactive	0.9%
660	Carcinoma, Endometrioid	0.9%
661	Chronic Fatigue Syndrome	0.9%
662	Endometrial Hyperplasia	0.9%
663	Pyometra	0.9%
664	Vaginitis	0.9%
665	Vulvitis	0.9%
666	Vaginal Discharge	0.9%
667	Vulvodynia	0.9%
668	Osteoarthritis, Knee	0.9%
669	Giant Cell Epulis	0.9%
670	Muscle Weakness	0.9%
671	Musculoskeletal Pain	0.9%
672	Arthralgia	0.9%
673	Polyarthralgia	0.9%
674	Testicular Neoplasms	0.9%
675	Prostatic Neoplasms, Castration-Resistant	0.9%
676	Ovarian Diseases	0.9%
677	Adnexitis	0.9%
678	Pruritus Vulvae	0.9%
679	Uterine hemorrhage	0.9%
680	Vaginal Fistula	0.9%
681	Pelvic Inflammatory Disease	0.9%
682	Uterine Prolapse	0.9%
683	Vaginal Prolapse	0.9%
684	Rheumatoid Nodule	0.8%
685	Myalgia	0.8%
686	Felty Syndrome	0.8%
687	Uterine Cervical Incompetence	0.8%
688	Nose Neoplasms	0.8%
689	Rheumatoid Vasculitis	0.8%
690	Melorheostosis	0.7%
691	Osteopetrosis	0.7%
692	Spondylolisthesis	0.7%
693	Sicca Syndrome	0.7%
694	Sjogren's Syndrome	0.7%
695	Chlamydia Infections	0.7%
696	Gonorrhea	0.7%
697	Ectopia Cordis	0.7%
698	Meningomyelocele	0.7%
699	Spina Bifida	0.7%
700	Single umbilical artery	0.7%
701	Syphilis	0.7%
702	granulosa cell tumor	0.7%
703	Carcinoma, Ovarian Epithelial	0.7%
704	Aortic coarctation	0.6%
705	Cor Triatriatum	0.6%
706	Coronary Vessel Anomalies	0.6%
707	Dental Enamel Hypoplasia	0.6%
708	Patent ductus arteriosus	0.6%
709	Ebstein Anomaly	0.6%
710	Heart Septal Defects	0.6%
711	Hyaline Membrane Disease	0.6%
712	Hypodontia	0.6%
713	Macrostomia	0.6%
714	Meningocele	0.6%
715	Microstomia	0.6%
716	Tetralogy of Fallot	0.6%
717	Transposition of Great Vessels	0.6%
718	Hypoplastic Left Heart Syndrome	0.6%
719	May-Thurner Syndrome	0.6%
720	Encephalocele	0.6%
721	Wolff-Parkinson-White Syndrome	0.6%
722	Candidiasis, Vulvovaginal	0.6%
723	Balanitis	0.6%
724	Benign prostatic hypertrophy	0.6%
725	Bunion	0.6%
726	Fibrodysplasia Ossificans Progressiva	0.6%
727	Myoglobinuria	0.6%
728	Myositis Ossificans	0.6%
729	Phimosis	0.6%
730	Priapism	0.6%
731	prostatitis	0.6%
732	Tenosynovitis	0.6%
733	Prostatic Adenoma	0.6%
734	Sacroiliitis	0.6%
735	Benign Prostatic Hyperplasia	0.6%
736	Prostatic Hypertrophy	0.6%
737	Prostatic Hyperplasia	0.6%
738	Long QT Syndrome	0.6%
739	Tricuspid Atresia	0.6%
740	Arrhythmogenic Right Ventricular Dysplasia	0.6%
741	Arthritis, Infectious	0.6%
742	Premature Ejaculation	0.6%
743	Erectile dysfunction	0.6%
744	Anterior Compartment Syndrome	0.6%
745	Orchitis	0.6%
746	Enthesopathy	0.6%
747	Arthritis, Experimental	0.6%
748	Abdominal Compartment Syndrome	0.6%
749	Polymyositis	0.6%
750	Abortion, Habitual	0.6%
751	Dystocia	0.6%
752	Eclampsia	0.6%
753	Fetal Membranes, Premature Rupture	0.6%
754	Placental Insufficiency	0.6%
755	Pre-Eclampsia	0.6%
756	Prenatal Exposure Delayed Effects	0.6%
757	HELLP Syndrome	0.6%
758	Placenta, Retained	0.6%
759	Uterine Cervicitis	0.5%
760	Leukorrhea	0.5%
761	Parametritis	0.5%
762	Hip Dislocation	0.5%
763	Shoulder Dislocation	0.5%
764	Hip Dysplasia	0.5%
765	Orbital Myositis	0.5%
766	Dupuytren Contracture	0.5%
767	Pyomyositis	0.5%
768	Abortion, Veterinary	0.5%
769	Pregnancy Complications, Parasitic	0.5%
770	Bacterial Vaginosis	0.5%
771	Lactation Disorder	0.5%
772	Mastitis	0.5%
773	Depression, Postpartum	0.5%
774	Embryo Loss	0.5%
775	Fetal Resorption	0.5%
776	Hyperemesis Gravidarum	0.5%
777	Trichomonas Vaginitis	0.5%
778	Uterine Perforation	0.5%
779	Ovarian Hyperstimulation Syndrome	0.5%
780	Metrorrhagia	0.5%
781	Shoulder Pain	0.5%
782	Trophoblastic Neoplasms	0.5%
783	Embolism, Amniotic Fluid	0.5%
784	Corpus Luteum Cyst	0.5%
785	Ovarian Cysts	0.5%
786	Breech Presentation	0.5%
787	Anovulation	0.5%
788	Menorrhagia	0.5%
789	Stillbirth	0.5%
790	Premature Menopause	0.5%
791	Lymphogranuloma Venereum	0.5%
792	Dermal Sinus	0.5%
793	Spina Bifida Cystica	0.5%
794	Spina Bifida Occulta	0.5%
795	Lissencephaly	0.5%
796	Polymicrogyria	0.5%
797	Pachygyria	0.5%
798	Schizencephaly	0.5%
799	Periventricular Nodular Heterotopia	0.5%
800	Endometrial Stromal Sarcoma	0.4%
801	Aortopulmonary Septal Defect	0.4%
802	Double Outlet Right Ventricle	0.4%
803	Endocardial Cushion Defects	0.4%
804	Myocardial bridging	0.4%
805	Aorticopulmonary Septal Defect	0.4%
806	Romano-Ward Syndrome	0.4%
807	Azoospermia	0.4%
808	Oligospermia	0.4%
809	Impotence, Vasculogenic	0.4%
810	Asthenozoospermia	0.4%
811	Teratozoospermia	0.4%
812	Aspermia	0.4%
813	Arteriovenous fistula	0.4%
814	Leydig Cell Tumor	0.3%
815	Polycystic Ovary Syndrome	0.3%
816	Truncus Arteriosus, Persistent	0.3%
817	Premature Birth	0.3%
818	Dermatomyositis	0.3%
819	Galactorrhea	0.3%
820	Choriocarcinoma	0.2%
821	Radicular Cyst	0.2%
822	Hydatidiform Mole	0.2%

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