MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Aortic Valve Insufficiency

(UMLS:C0003504)

Definition:: Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
UMLS ID:: C0003504
MeSH ID:: D001022

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.484.095

Synonym(s)

Aortic Valve Insufficiency

AI - Aortic incompetence

AORTIC INSUFFICIENCY

AORTIC REGURGITATION

AORTIC VALVE INCOMPETENCE

AORTIC VALVE INSUFFICIENCY

AORTIC VALVE REGURGITATION

AORTIC VALVE, INCOMPETENCE

AORTIC VALVE, INSUFFICIENCY

10.

AR - Aortic regurgitation

11.

Aortic (valve) insufficiency

12.

Aortic Insufficiency

13.

Aortic Regurgitation

14.

Aortic Valve Regurgitation

15.

Aortic incompetence

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Bromocriptine	18989898	CTD
2	Cabergoline	17202454 17307289 18398916	CTD
3	Carvedilol	21216836	CTD
4	Cilazapril	9499499	CTD
5	Cyproheptadine	19346455	CTD
6	Dexfenfluramine	View details 9385873 9437392 9731086 9731087 9731088 10440587 10533670 10533956 10571975 10614800 10755496 11171493 11182835 12079711 12194699 12801402 12904610 19947311	CTD
7	Fenfluramine	View details 9280830 9385873 9437392 9731086 9731087 9867728 10440587 10533670 10533956 10593346 10614800 10755496 10790349 10807073 10867106 11171493 11182835 11581595 11735689 12050608 12079711 12194699 12486432 12686663 12801402 17383382 17626991 18990200	CTD
8	Ketamine	18455290	CTD
9	Mazindol	10440587	CTD
10	Methysergide	912852 12848667	CTD
11	Nifedipine	2197314 6491083 8213512	CTD
12	Pergolide	View details 12934784 15277624 15868996 16092580 17202454 17307289 17353380 17636306 18560792 18579494 18989898 19346455 19912629	CTD
13	Phentermine	View details 9280830 9385873 9437392 9731086 9867728 10440587 10533956 10593346 10614800 10755496 10790349 10807073 10867106 11581595 11735689 12050608 12194699 17626991	CTD
14	Phentolamine	7258732	CTD
15	Serotonin	17636306	CTD
16	Xylazine	18455290	CTD
17	benfluorex	12605770	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Mitral Valve Insufficiency	46.7%
2	Mitral Valve Stenosis	46.7%
3	Pulmonary Valve Insufficiency	46.7%
4	Tricuspid Valve Insufficiency	46.7%
5	Tricuspid Valve Stenosis	46.7%
6	Aortic Valve Stenosis	44.4%
7	Pulmonary Valve Stenosis	44.4%
8	Aortic Valve Prolapse	34.4%
9	Tricuspid Valve Prolapse	34.4%
10	Supravalvular aortic stenosis	32.6%
11	Hypertrophic Cardiomyopathy	32.2%
12	Hypertrophic obstructive cardiomyopathy	32.2%
13	Cardiac Tamponade	31%
14	Endocarditis	31%
15	Cardiac Arrest	31%
16	Heart failure	31%
17	Pericardial effusion	31%
18	Pericarditis	31%
19	Pneumopericardium	31%
20	Cor pulmonale	31%
21	Ventricular Outflow Obstruction	31%
22	Ventricular Dysfunction	31%
23	Cardiomyopathies	31%
24	Pleuropericarditis	31%
25	Tricuspid Atresia	29.1%
26	Myocardial Ischemia	27.9%
27	Cardiomyopathy, Dilated	26.7%
28	Cardiac Output, High	20.9%
29	Myocardial Stunning	20.9%
30	Low Cardiac Output Syndrome	20.9%
31	Cardiomegaly	20.5%
32	Postpericardiotomy Syndrome	20.5%
33	Cardiac Hypertrophy	20.5%
34	Rheumatic Heart Disease	20.1%
35	Restrictive cardiomyopathy	20%
36	Endocardial Fibroelastosis	20%
37	Heart Block	20%
38	Heart Rupture, Post-Infarction	20%
39	Myocarditis	20%
40	Pericarditis, Constrictive	20%
41	Tachycardia	20%
42	Tachyarrhythmia	20%
43	Ventricular Dysfunction, Left	20%
44	Right Ventricular Dysfunction	20%
45	Endomyocardial Fibrosis	20%
46	Carditis	20%
47	Heart Failure, Systolic	20%
48	Heart Failure, Diastolic	20%
49	Lown-Ganong-Levine Syndrome	19.6%
50	Arrhythmogenic Right Ventricular Dysplasia	18.5%
51	Vascular Diseases	18.5%
52	Coronary heart disease	17.8%
53	Myocardial Infarction	17.8%
54	Acute Coronary Syndrome	17.8%
55	Myocardial Reperfusion Injury	17.7%
56	Long QT Syndrome	15.9%
57	Takotsubo Cardiomyopathy	14.8%
58	Adams-Stokes Syndrome	14.6%
59	Atrioventricular Block	14.6%
60	Bundle-Branch Block	14.6%
61	Atrial Premature Complexes	14.6%
62	Sinoatrial Block	14.6%
63	Tachycardia, Paroxysmal	14.6%
64	Supraventricular tachycardia	14.6%
65	Tachycardia, Ventricular	14.6%
66	Wolff-Parkinson-White Syndrome	14.6%
67	Tachycardia, Reciprocating	14.6%
68	Sick Sinus Syndrome	14.6%
69	Kounis Syndrome	13.6%
70	Sinus Arrhythmia	13.3%
71	Atrial Fibrillation	13.3%
72	Atrial Flutter	13.3%
73	Edema, Cardiac	13.3%
74	Ventricular Fibrillation	13.3%
75	Ventricular Flutter	13.3%
76	Parasystole	13.3%
77	Paroxysmal atrial fibrillation	13.3%
78	Bradycardia	13.3%
79	Diabetic Cardiomyopathies	13.3%
80	Aortic coarctation	13.2%
81	Cor Triatriatum	13.2%
82	Coronary Vessel Anomalies	13.2%
83	Patent ductus arteriosus	13.2%
84	Ebstein Anomaly	13.2%
85	Heart Septal Defects	13.2%
86	Tetralogy of Fallot	13.2%
87	Transposition of Great Vessels	13.2%
88	Hypoplastic Left Heart Syndrome	13.2%
89	Cardiomyopathy, Alcoholic	13.2%
90	Sudden Cardiac Death	13.2%
91	Left Ventricular Hypertrophy	13.2%
92	Right Ventricular Hypertrophy	13.2%
93	Angina Pectoris	13.2%
94	Chagas Cardiomyopathy	13.1%
95	Coronary Aneurysm	13.1%
96	Coronary Occlusion	13%
97	Microvascular Angina	13%
98	Coronary Stenosis	13%
99	ST segment elevation myocardial infarction	13%
100	Bacterial Endocarditis	12.3%
101	Coronary Thrombosis	12.2%
102	Pregnancy Complications, Cardiovascular	12.2%
103	Cardiovascular Abnormalities	12.2%
104	Coronary Artery Disease	12.2%
105	Tachycardia, Atrioventricular Nodal Reentry	12%
106	Tachycardia, Ectopic Atrial	12%
107	Tachycardia, Ectopic Junctional	12%
108	Sinus Tachycardia	12%
109	Torsades de Pointes	12%
110	Accelerated Idioventricular Rhythm	12%
111	Carcinoid Heart Disease	11.7%
112	Romano-Ward Syndrome	11.7%
113	Williams Syndrome	11.5%
114	Coronary Restenosis	10.8%
115	Dextrocardia	10.6%
116	Aneurysm	10.3%
117	Angiomatosis	10.3%
118	Aortic Diseases	10.3%
119	Arterial Occlusive Diseases	10.3%
120	Hyperemia	10.3%
121	Hypotension	10.3%
122	Superior Vena Cava Syndrome	10.3%
123	Telangiectasis	10.3%
124	Vasculitis	10.3%
125	Venous Insufficiency	10.3%
126	Peripheral Vascular Diseases	10.3%
127	Embolism and Thrombosis	10.3%
128	Angiodysplasia	10.3%
129	Capillary Leak Syndrome	10.3%
130	Prehypertension	10.3%
131	Dyspnea, Paroxysmal	9.9%
132	Shock, Cardiogenic	9.8%
133	Sinus Arrest, Cardiac	9.8%
134	Aortopulmonary Septal Defect	9.7%
135	Double Outlet Right Ventricle	9.7%
136	Endocardial Cushion Defects	9.7%
137	Myocardial bridging	9.7%
138	Aorticopulmonary Septal Defect	9.7%
139	Angina, Unstable	9.7%
140	Aortic Aneurysm	8.9%
141	Aortitis	8.9%
142	Leriche Syndrome	8.9%
143	Periphlebitis	8.9%
144	Phlebitis	8.9%
145	Thromboangiitis Obliterans	8.9%
146	Truncus Arteriosus, Persistent	8%
147	Angina Pectoris, Variant	8%
148	Postphlebitic Syndrome	7.7%
149	Noonan Syndrome	7.6%
150	Embolism, Amniotic Fluid	7.6%
151	Vascular System Injuries	7.3%
152	Retinal Vein Occlusion	7.2%
153	Subacute Bacterial Endocarditis	7.1%
154	Compartment syndromes	7%
155	Hepatic Veno-Occlusive Disease	7%
156	Peliosis Hepatis	7%
157	Varicocele	7%
158	Thrombophlebitis	6.9%
159	Cerebrovascular Disorders	6.8%
160	Diabetic Angiopathies	6.8%
161	Reperfusion Injury	6.8%
162	Splenic Infarction	6.8%
163	Cerebrovascular Insufficiency	6.8%
164	Vascular Neoplasms	6.8%
165	Spinal Cord Vascular Diseases	6.8%
166	Vasoplegia	6.8%
167	Blue Toe Syndrome	6.8%
168	Marfan Syndrome	6.8%
169	Hemorrhoids	6.7%
170	Thoracic Outlet Syndrome	6.7%
171	Aneurysm, Dissecting	6.7%
172	Arteriosclerosis	6.7%
173	Arteritis	6.7%
174	Embolism	6.7%
175	Erythromelalgia	6.7%
176	Fibromuscular Dysplasia	6.7%
177	Malignant Hypertension	6.7%
178	Raynaud Disease	6.7%
179	Thromboembolism	6.7%
180	Thrombosis	6.7%
181	Essential Hypertension	6.7%
182	Aneurysm, Ruptured	6.7%
183	Iliac Aneurysm	6.7%
184	Malignant Atrophic Papulosis	6.7%
185	Pulmonary artery stenosis	6.7%
186	White Coat Hypertension	6.7%
187	Systemic Vasculitis	6.7%
188	Embolus	6.7%
189	Shwartzman Phenomenon	6.6%
190	May-Thurner Syndrome	6.6%
191	Arteriovenous fistula	6.5%
192	Aortic Aneurysm, Abdominal	6.5%
193	Aortic Aneurysm, Thoracic	6.5%
194	Aortic Rupture	6%
195	Intracranial Embolism and Thrombosis	5.7%
196	Carotid Stenosis	5.7%
197	Intracranial Aneurysm	5.7%
198	Carotid Artery Thrombosis	5.5%
199	Hand-Arm Vibration Syndrome	5.4%
200	Optic Neuropathy, Ischemic	5.2%
201	Anterior Ischemic Optic Neuropathy	5.2%
202	Mesenteric vascular insufficiency	5.2%
203	Moyamoya Disease	5.1%
204	Angioedema	5%
205	Colitis, Ischemic	5%
206	Arteriosclerosis Obliterans	4.9%
207	Atherosclerosis	4.9%
208	Air Embolism	4.9%
209	Endarteritis	4.9%
210	Polyarteritis Nodosa	4.9%
211	Takayasu Arteritis	4.9%
212	Venous Thrombosis	4.9%
213	Deep Vein Thrombosis	4.9%
214	Venous Thromboembolism	4.9%
215	Scimitar Syndrome	4.9%
216	Intracranial Arteriosclerosis	4.9%
217	Cerebral Atherosclerosis	4.9%
218	Cerebral Arteriosclerosis	4.9%
219	Retinal Artery Occlusion	4.5%
220	Retinal Vasculitis	4.5%
221	Hypertensive Retinopathy	4.5%
222	Vasculitis, Central Nervous System	4.5%
223	Anterior Compartment Syndrome	4.4%
224	Vasculitis, Leukocytoclastic, Cutaneous	4.4%
225	Gastric Antral Vascular Ectasia	4.4%
226	Abdominal Compartment Syndrome	4.4%
227	Cerebral Thrombosis	4.4%
228	Intracranial Embolism	4.4%
229	Intracranial Thrombosis	4.4%
230	Carotid Artery Diseases	4.4%
231	Brain Ischemia	4.4%
232	Ectopia Cordis	4.4%
233	Hypotension, Orthostatic	4.4%
234	Cerebrovascular accident	4.4%
235	Varicose Ulcer	4.4%
236	Vasospasm, Intracranial	4.4%
237	Spinal Cord Ischemia	4.4%
238	Intracranial Arterial Diseases	4.4%
239	Primary Graft Dysfunction	4.4%
240	Single umbilical artery	4.4%
241	Post-Exercise Hypotension	4.4%
242	Brain Infarction	3.9%
243	Sinus Thrombosis, Intracranial	3.8%
244	Turner Syndrome	3.7%
245	Giant Cell Arteritis	3.7%
246	Temporal Arteritis	3.7%
247	Kearns-Sayre syndrome	3.5%
248	Cavernous Sinus Thrombosis	3.5%
249	Sagittal Sinus Thrombosis	3.5%
250	Lemierre Syndrome	3.4%
251	Mesenteric Vascular Occlusion	3.4%
252	Mucocutaneous Lymph Node Syndrome	3.4%
253	Intermittent Claudication	3.4%
254	Pulmonary Embolism	3.4%
255	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.4%
256	Diabetic Retinopathy	3.4%
257	Sturge-Weber Syndrome	3.4%
258	Livedo Reticularis	3.3%
259	Renal hypertension	3.3%
260	Renal Artery Obstruction	3.3%
261	Renal Artery Stenosis	3.3%
262	No-Reflow Phenomenon	3.3%
263	Hemangioma, Cavernous	3.3%
264	Basal Ganglia Cerebrovascular Disease	3.3%
265	Vertebral Artery Dissection	3.3%
266	Vascular Headaches	3.3%
267	Scurvy	3.3%
268	CREST Syndrome	3.2%
269	Cerebral Arterial Diseases	3.2%
270	Vertebrobasilar Insufficiency	3.2%
271	Anterior Spinal Artery Syndrome	3.2%
272	Basilar Artery Stenosis	3.2%
273	Vertebral Artery Stenosis	3.2%
274	Intracranial Hemorrhage, Hypertensive	3.2%
275	Transient Cerebral Ischemia	3.2%
276	Subarachnoid Hemorrhage, Traumatic	3.2%
277	Carotid Artery, Internal, Dissection	3.2%
278	Cerebral Infarction	3.2%
279	Brain Stem Infarctions	3.2%
280	Infarction, Middle Cerebral Artery	3.2%
281	Infarction, Anterior Cerebral Artery	3.2%
282	Infarction, Posterior Cerebral Artery	3.2%
283	Kartagener Syndrome	3.1%
284	Lateral Medullary Syndrome	2.9%
285	Hepatic Vein Thrombosis	2.8%
286	Budd-Chiari Syndrome	2.8%
287	Carotid Artery Injuries	2.8%
288	Pulmonary Infarction	2.7%
289	Dural Arteriovenous Fistula	2.7%
290	Subclavian Steal Syndrome	2.7%
291	Ischemic contracture	2.7%
292	Angioedemas, Hereditary	2.6%
293	Cryoglobulinemia	2.6%
294	Leukomalacia, Periventricular	2.6%
295	Diabetic Foot	2.6%
296	Basal Ganglia Hemorrhage	2.5%
297	Hypertension, Renovascular	2.4%
298	Subarachnoid Hemorrhage	2.4%
299	Hypoxia-Ischemia, Brain	2.4%
300	Cerebral Hemorrhage	2.4%
301	Hereditary Angioedema Type III	2.4%
302	Hereditary Angioedema Types I and II	2.4%
303	Shy-Drager Syndrome	2.2%
304	Purpura, Hyperglobulinemic	2.2%
305	Putaminal Hemorrhage	2.2%
306	Granulomatosis with polyangiitis	2.1%
307	Dementia, Vascular	2%
308	Cerebral Amyloid Angiopathy	2%
309	Pituitary Apoplexy	2%
310	Behcet Syndrome	1.9%
311	Waldenstrom Macroglobulinemia	1.9%
312	Multiple Myeloma	1.9%
313	Ataxia Telangiectasia	1.7%
314	Pseudoxanthoma Elasticum	1.7%
315	Rheumatoid Vasculitis	1.6%
316	Lupus Vasculitis, Central Nervous System	1.6%
317	Hematoma, Subdural	1.2%
318	Hematoma, Epidural, Cranial	1.2%
319	Hematoma, Subdural, Intracranial	1%
320	Hematoma, Subdural, Chronic	1%
321	Hematoma, Subdural, Acute	1%
322	Brain Hemorrhage, Traumatic	1%
323	MELAS Syndrome	1%
324	Fabry Disease	0.7%

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