MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Celiac Disease

(UMLS:C0007570)

Definition:: A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.
UMLS ID:: C0007570
MeSH ID:: D002446

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.469.637.250

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.603.250

Synonym(s)

Celiac Disease

CD - Celiac disease

CD - Coeliac disease

CELIAC DISEASE

CELIAC SPRUE

CS - Celiac sprue

CS - Coeliac sprue

Celiac Sprue

Celiac disease

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Azathioprine	12950421	CTD
2	Mesalamine	20871406	CTD
3	Prednisone	12950421	CTD
4	Vitamin B 12	11943958	CTD
5	tofacitinib	23269601	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Sprue, Tropical	47.5%
2	Steatorrhea	47.5%
3	Lactose Intolerance	36.4%
4	Dysentery	24.8%
5	Enteritis	24.8%
6	Enterocolitis	24.8%
7	Inflammatory Bowel Diseases	24.8%
8	Short Bowel Syndrome	24.6%
9	Cecal Diseases	23.1%
10	Colonic Diseases	23.1%
11	Ileal Diseases	23.1%
12	Intestinal Obstruction	23.1%
13	Intestinal Perforation	23.1%
14	Jejunal Diseases	23.1%
15	Pneumatosis Cystoides Intestinalis	23.1%
16	Rectal Diseases	23.1%
17	Cronkhite-Canada Syndrome	23.1%
18	Intestinal Polyposis	23.1%
19	Duodenal Obstruction	22.8%
20	Duodenitis	22.1%
21	Ileitis	22.1%
22	Erosive Duodenitis	22.1%
23	Zollinger-Ellison syndrome	21.4%
24	Hyperhomocysteinemia	21.2%
25	Wasting Syndrome	20.5%
26	Acid-Base Imbalance	20.2%
27	Calcium Metabolism Disorders	20.2%
28	Iron Metabolism Disorders	20.2%
29	Phosphorus Metabolism Disorders	20.2%
30	Water-Electrolyte Imbalance	20.2%
31	Lipid Metabolism Disorders	20.2%
32	Mitochondrial Diseases	20.2%
33	Glucose Metabolism Disorders	20.2%
34	Colorectal Neoplasms	20.2%
35	Proctocolitis	20%
36	Hypercalcemia	19.8%
37	Hypocalcemia	19.8%
38	Milk-Alkali Syndrome	19.8%
39	Colitis	18.9%
40	Duodenogastric Reflux	18.9%
41	Peptic Ulcer	18.9%
42	Proctitis	18.9%
43	Intestinal Diseases, Parasitic	18.3%
44	Intestinal Neoplasms	18.1%
45	Mesenteric vascular insufficiency	17.7%
46	Intestinal Atresia	17.4%
47	Mesenteric Vascular Occlusion	17.4%
48	Achlorhydria	17.4%
49	Intestinal Fistula	17.3%
50	Enterocutaneous Fistula	17.3%
51	Esophageal Diseases	16.9%
52	Gastroenteritis	16.9%
53	Stomach Diseases	16.9%
54	Rectal Fistula	16.8%
55	Anal Fistula	16.8%
56	Cecal Neoplasms	16.6%
57	Duodenal Neoplasms	16.6%
58	Pouchitis	16.4%
59	Crohn Disease	16.3%
60	Enterocolitis, Neutropenic	16.3%
61	Necrotizing Enterocolitis	16.3%
62	Lipodystrophy	15.9%
63	Colonic Pseudo-Obstruction	15.5%
64	Pseudohypoparathyroidism	15.5%
65	Osteopenia	15.4%
66	Colonic Diseases, Functional	15.2%
67	Fecal Incontinence	15.2%
68	Fecal Impaction	15.2%
69	Intussusception	15.2%
70	Megacolon	15.2%
71	Ileus	15.2%
72	Meconium ileus	15.2%
73	Appendicitis	15.1%
74	Brain Diseases, Metabolic	15.1%
75	Esophagitis	14.9%
76	Gastritis	14.9%
77	Rickets	14.4%
78	Gastrointestinal Neoplasms	13.6%
79	Leigh Disease	13.5%
80	Duodenal Ulcer	13.4%
81	Peptic Ulcer Perforation	13.4%
82	Gastric ulcer	13.4%
83	Acidosis	13.2%
84	Alkalosis	13.2%
85	Amyloidosis	13.2%
86	Calcinosis	13.2%
87	Hyperglycemia	13.2%
88	Hyperinsulinism	13.2%
89	Hyperkalemia	13.2%
90	Hypernatremia	13.2%
91	Hypoglycemia	13.2%
92	Hypokalemia	13.2%
93	Hyponatremia	13.2%
94	Xanthomatosis	13.2%
95	Hypophosphatemia	13.2%
96	Metabolic acidosis	13.2%
97	Dyslipidemias	13.2%
98	Iron Overload	13.2%
99	Xanthoma	13.2%
100	Brain Diseases, Metabolic, Inborn	13.2%
101	Anus Neoplasms	13.1%
102	Sigmoid Neoplasms	13.1%
103	Enterocolitis, Pseudomembranous	13%
104	pseudomembranous colitis	13%
105	Dysentery, Bacillary	13%
106	Congenital Hyperinsulinism	12.8%
107	Gastrointestinal Hemorrhage	12.6%
108	Tuberculosis, Gastrointestinal	12.4%
109	Appendiceal Neoplasms	12.3%
110	Colonic Neoplasms	12.3%
111	Rectal Neoplasms	12.3%
112	Carbamoyl-Phosphate Synthase I Deficiency Disease	12.3%
113	Adenomatous Polyposis Coli	12.1%
114	Hyperlipoproteinemia Type IV	12.1%
115	Hyperlipoproteinemia Type V	12.1%
116	Nutrition Disorders	11.8%
117	Hypolipoproteinemias	11.7%
118	Hemorrhoids	11.7%
119	Stomach Neoplasms	11.5%
120	Afferent Loop Syndrome	11.5%
121	Rectocele	11.5%
122	Rectal Prolapse	11.4%
123	Anal Fissure	11.4%
124	Intestinal Pseudo-Obstruction	11.4%
125	Irritable Bowel Syndrome	11.4%
126	Superior Mesenteric Artery Syndrome	11.4%
127	Neurogenic Bowel	11.4%
128	Anal Ulcer	11.4%
129	Smith-Lemli-Opitz Syndrome	11%
130	Galactosemias	10.9%
131	Urea Cycle Disorders, Inborn	10.9%
132	Tyrosinemias	10.9%
133	Colitis, Ischemic	10.9%
134	Osteomalacia	10.8%
135	Diabetic Ketoacidosis	10.7%
136	Familial Hypophosphatemic Rickets	10.7%
137	Hyperlipidemia, Familial Combined	10.7%
138	Biliary Tract Diseases	10.6%
139	Liver diseases	10.6%
140	Pancreatic Diseases	10.6%
141	Diabetes Mellitus	10.4%
142	Hyperlipoproteinemia Type III	10.2%
143	Dehydration	10.1%
144	Lipomatosis	10.1%
145	Water Intoxication	10.1%
146	Werner Syndrome	10.1%
147	Gaucher Disease	10%
148	Amino Acid Metabolism, Inborn Errors	9.9%
149	Bloom Syndrome	9.9%
150	Carbohydrate Metabolism, Inborn Errors	9.9%
151	Esophageal and Gastric Varices	9.9%
152	Metal Metabolism, Inborn Errors	9.9%
153	Osteoporosis	9.9%
154	Progeria	9.9%
155	Lysosomal Storage Diseases	9.9%
156	Bone Demineralization, Pathologic	9.9%
157	Cytochrome-c Oxidase Deficiency	9.9%
158	Peroxisomal Disorders	9.9%
159	Post-Traumatic Osteoporosis	9.9%
160	Esophageal Neoplasms	9.9%
161	Esophageal Stenosis	9.9%
162	Gastric Dilatation	9.9%
163	Gastric outlet obstruction	9.9%
164	Reye Syndrome	9.9%
165	Mitochondrial Encephalomyopathies	9.8%
166	Acidosis, Lactic	9.8%
167	Calciphylaxis	9.8%
168	Hemosiderosis	9.8%
169	Ketosis	9.8%
170	Nesidioblastosis	9.8%
171	Ketonuria	9.8%
172	Ketoacidosis	9.8%
173	Ketonemia	9.8%
174	Vascular calcification	9.8%
175	Hyperphosphaturia	9.7%
176	Hypoalphalipoproteinemias	9.6%
177	Glycogen storage disease type II	9.6%
178	Porphyrias, Hepatic	9.5%
179	Giardiasis	9.5%
180	Esophageal Atresia	9.4%
181	Homocystinuria	9.2%
182	Hepatic Encephalopathy	9.2%
183	Tay-Sachs Disease	8.9%
184	Zellweger Syndrome	8.7%
185	Amyloid Neuropathies, Familial	8.7%
186	Pruritus Ani	8.6%
187	Niemann-Pick Disease, Type C	8.5%
188	Renal tubular acidosis	8.3%
189	Hypercholesterolemia	8.1%
190	Hyperlipoproteinemias	8.1%
191	Hypertriglyceridemia	8.1%
192	Hepatolenticular Degeneration	8.1%
193	Mitochondrial Myopathies	8.1%
194	Myelinolysis, Central Pontine	8%
195	Digestive System Neoplasms	8%
196	Glycosuria	7.9%
197	Gastrointestinal Stromal Tumors	7.9%
198	Fabry Disease	7.9%
199	Esophageal Perforation	7.8%
200	Peutz-Jeghers Syndrome	7.7%
201	Neuronal Ceroid-Lipofuscinoses	7.7%
202	Barrett Esophagus	7.6%
203	Deglutition Disorders	7.6%
204	Adrenoleukodystrophy	7.5%
205	HIV Wasting Syndrome	7.5%
206	MELAS Syndrome	7.5%
207	Gastric Antral Vascular Ectasia	7.4%
208	Acidosis, Respiratory	7.4%
209	Adiposis Dolorosa	7.4%
210	Alkalosis, Respiratory	7.4%
211	Peptic Ulcer Hemorrhage	7.4%
212	Gastroparesis	7.4%
213	Alkaptonuria	7.3%
214	Glycogen Storage Disease	7.3%
215	Hypophosphatasia	7.3%
216	Insulin Resistance	7.3%
217	Osteoporosis, Postmenopausal	7.3%
218	Propionic acidemia	7.3%
219	Dihydropyrimidine Dehydrogenase Deficiency	7.3%
220	Cystinosis	7.3%
221	HIV-Associated Lipodystrophy Syndrome	7.3%
222	Menkes Kinky Hair Syndrome	7.3%
223	Renal Osteodystrophy	7.2%
224	Renal rickets	7.2%
225	Mucopolysaccharidosis III	6.9%
226	Liver neoplasms	6.8%
227	Pancreatic Fistula	6.8%
228	Child Nutrition Disorders	6.7%
229	Hypervitaminosis A	6.7%
230	Infant Nutrition Disorders	6.7%
231	Malnutrition	6.7%
232	Refsum Disease	6.7%
233	Wernicke Encephalopathy	6.6%
234	Necrobiosis Lipoidica Diabeticorum	6.6%
235	Esophageal motility disorders	6.5%
236	Fanconi Anemia	6.5%
237	Mallory-Weiss Syndrome	6.5%
238	Pyloric Stenosis	6.5%
239	Variegate Porphyria	6.5%
240	Acute intermittent porphyria	6.5%
241	Porphyria Cutanea Tarda	6.5%
242	Glycosuria, Renal	6.5%
243	Gestational Diabetes	6.1%
244	Latent Autoimmune Diabetes in Adults	6.1%
245	Glycogen Storage Disease Type I	6%
246	Glycogen Storage Disease Type V	6%
247	Diabetes Mellitus, Experimental	6%
248	Melena	6%
249	Hematemesis	5.9%
250	Nephrocalcinosis	5.9%
251	Tetany	5.9%
252	Cryptosporidiosis	5.8%
253	Cerebral Amyloid Angiopathy	5.8%
254	Peritoneal Neoplasms	5.6%
255	Bile Duct Diseases	5.6%
256	Cholelithiasis	5.6%
257	Chylous Ascites	5.6%
258	Fatty Liver	5.6%
259	Hepatitis	5.6%
260	Portal Hypertension	5.6%
261	Liver Cirrhosis	5.6%
262	Pancreatic Insufficiency	5.6%
263	Pancreatitis	5.6%
264	Pneumoperitoneum	5.6%
265	Focal Nodular Hyperplasia	5.6%
266	Hepatic Insufficiency	5.6%
267	Steatohepatitis	5.6%
268	Friedreich Ataxia	5.6%
269	CREST Syndrome	5.5%
270	Kearns-Sayre syndrome	5.2%
271	Kernicterus	5%
272	Familial Periodic Paralysis	5%
273	Cockayne Syndrome	5%
274	Cholecystolithiasis	5%
275	Bile Duct Neoplasms	4.9%
276	gallbladder neoplasm	4.9%
277	Primary amyloidosis	4.9%
278	Biliary cirrhosis	4.9%
279	Sjogren-Larsson Syndrome	4.9%
280	Diverticulitis	4.9%
281	Dumping Syndrome	4.9%
282	Pancreatic Neoplasm	4.9%
283	Esophageal Achalasia	4.9%
284	Canavan Disease	4.9%
285	Alexander Disease	4.9%
286	Renal Aminoacidurias	4.9%
287	Fanconi Syndrome	4.9%
288	Pseudohypoaldosteronism	4.9%
289	Liddle Syndrome	4.9%
290	Mucopolysaccharidosis II	4.8%
291	Choledochal Cyst	4.5%
292	Ataxia Telangiectasia	4.5%
293	Liver Diseases, Parasitic	4.4%
294	Deficiency Diseases	4.4%
295	Starvation	4.4%
296	Refeeding Syndrome	4.4%
297	Optic Atrophy, Hereditary, Leber	4.3%
298	Hepatic Veno-Occlusive Disease	4.3%
299	Pancreatic Cyst	4.3%
300	Peliosis Hepatis	4.3%
301	Hepatopulmonary Syndrome	4.3%
302	Gout	4.3%
303	Amyotrophic Lateral Sclerosis	4.2%
304	Anus, Imperforate	4.2%
305	Hemoperitoneum	4.2%
306	Hepatomegaly	4.2%
307	Mesenteric Panniculitis	4.2%
308	Panniculitis, Peritoneal	4.2%
309	Peritonitis	4.2%
310	Peritoneal Fibrosis	4.2%
311	Encapsulating Peritoneal Sclerosis	4.2%
312	Anorectal Malformations	4.2%
313	Antley-Bixler Syndrome Phenotype	4.2%
314	Biliary Fistula	4.2%
315	Gastric Fistula	4.2%
316	Hepatic Vein Thrombosis	4.1%
317	Liver Abscess	4.1%
318	Budd-Chiari Syndrome	4.1%
319	Choledocholithiasis	4.1%
320	Hypokalemic periodic paralysis	4.1%
321	Frontotemporal dementia	4%
322	Xeroderma Pigmentosum	4%
323	Cystinuria	4%
324	Diverticulum	4%
325	Diverticulosis	4%
326	Fatty Liver, Alcoholic	3.9%
327	Hepatitis, Alcoholic	3.9%
328	Liver Cirrhosis, Alcoholic	3.9%
329	Arthritis, Gouty	3.5%
330	Chemical and Drug Induced Liver Injury	3.4%
331	Hepatorenal Syndrome	3.3%
332	Albinism	3.3%
333	Cholangitis	3.3%
334	Cholecystitis	3.3%
335	Cholestasis	3.3%
336	Common Bile Duct Diseases	3.3%
337	Hepatitis, Chronic	3.3%
338	Liver Failure	3.3%
339	Pancreatitis, Chronic	3.3%
340	Non-alcoholic Fatty Liver Disease	3.3%
341	Chronic active hepatitis	3.3%
342	Hepatocellular Adenoma	3.3%
343	Kwashiorkor	3.3%
344	Magnesium Deficiency	3.3%
345	Potassium Deficiency	3.3%
346	Protein Deficiency	3.3%
347	Avitaminosis	3.3%
348	Laryngopharyngeal Reflux	3.1%
349	Cystic Fibrosis	2.9%
350	Liver Abscess, Amebic	2.8%
351	Liver Neoplasms, Experimental	2.8%
352	Ascorbic Acid Deficiency	2.7%
353	Vitamin A Deficiency	2.7%
354	Vitamin D Deficiency	2.7%
355	Vitamin E Deficiency	2.7%
356	Marasmus	2.7%
357	Ichthyosis, X-Linked	2.7%
358	Hepatitis, Animal	2.6%
359	Hepatitis, Viral, Human	2.6%
360	Liver Cirrhosis, Experimental	2.5%
361	Pancreatic Pseudocyst	2.5%
362	Pancreatitis, Alcoholic	2.5%
363	Folic Acid Deficiency	2.4%
364	Pellagra	2.4%
365	Thiamine Deficiency	2.4%
366	Vitamin B 12 Deficiency	2.4%
367	Vitamin B 6 Deficiency	2.4%
368	Pyridoxine Deficiency	2.4%
369	Beriberi	2.3%
370	Cholestasis, Extrahepatic	2.2%
371	Biliary Dyskinesia	2.2%
372	Cholangitis, Sclerosing	2.2%
373	Liver Failure, Acute	2.2%
374	Acalculous Cholecystitis	2.2%
375	End Stage Liver Disease	2.2%
376	Carcinoma, Pancreatic Ductal	2.2%
377	Obesity	2.2%
378	Fascioliasis	2%
379	Echinococcosis, Hepatic	2%
380	Chemical and Drug Induced Liver Injury, Chronic	2%
381	Obesity, Abdominal	1.9%
382	Hepatitis B, Chronic	1.9%
383	Hepatitis C, Chronic	1.9%
384	Anemia, Pernicious	1.7%
385	Autoimmune hepatitis	1.7%
386	Vitamin K Deficiency	1.6%
387	Massive Hepatic Necrosis	1.6%
388	Emphysematous Cholecystitis	1.6%
389	Sphincter of Oddi Dysfunction	1.6%
390	insulinoma	1.6%
391	Gastrinoma	1.6%
392	Glucagonoma	1.6%
393	Pediatric Obesity	1.6%
394	Scurvy	1.5%
395	Vipoma	1.4%
396	Prader-Willi Syndrome	1.4%
397	Hepatitis, Viral, Animal	1.4%
398	Hepatitis E	1.4%
399	Hepatitis B	1.3%
400	Hepatitis C	1.3%
401	Hepatitis A	1.3%
402	Subacute Combined Degeneration	1%
403	Rift Valley Fever	0.6%

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