MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Neuronal Ceroid-Lipofuscinoses

(UMLS:C0027877)

Definition:: A group of severe neurodegenerative diseases characterized by intracellular accumulation of autofluorescent wax-like lipid materials (CEROID; LIPOFUSCIN) in neurons. There are several subtypes based on mutations of the various genes, time of disease onset, and severity of the neurological defects such as progressive DEMENTIA; SEIZURES; and visual failure.
UMLS ID:: C0027877
MeSH ID:: D009472

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.574.500.550

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.400.600|C16.320.565.398.641.509

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.687.509|C18.452.648.398.641.509

Synonym(s)

Neuronal Ceroid-Lipofuscinoses

CEROID STORAGE DISEASE

Cerebral lipofuscinosis

Cerebromacular degeneration

Cerebromacular dystrophy

Cerebroretinal degeneration disease

Neuronal Ceroid Lipofuscinosis

Neuronal ceroid lipofuscinosis

Neuronal ceroid-lipofuscinosis

10.

Pigmentary retinal lipoid neuronal heredodegeneration

11.

ceroid lipofuscinoses neuronal

12.

ceroid lipofuscinosis

13.

ceroid-lipofuscinosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fenretinide		16303764	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Smith-Lemli-Opitz Syndrome	35.7%
2	Sjogren-Larsson Syndrome	32.3%
3	Hypolipoproteinemias	31.8%
4	Hepatolenticular Degeneration	31.8%
5	Amyloid Neuropathies, Familial	31.8%
6	Cockayne Syndrome	31.6%
7	Gaucher Disease	30.2%
8	Hyperlipidemia, Familial Combined	29.7%
9	Hyperlipoproteinemia Type IV	29.3%
10	Hyperlipoproteinemia Type V	29.3%
11	Fabry Disease	29.1%
12	Refsum Disease	28.8%
13	Hyperlipoproteinemia Type III	28.7%
14	Brain Diseases, Metabolic, Inborn	27.5%
15	Menkes Kinky Hair Syndrome	27.3%
16	Canavan Disease	26.3%
17	Alexander Disease	26.3%
18	Amino Acid Metabolism, Inborn Errors	26.2%
19	Carbohydrate Metabolism, Inborn Errors	26.2%
20	Metal Metabolism, Inborn Errors	26.2%
21	Progeria	26.2%
22	Lysosomal Storage Diseases	26.2%
23	Peroxisomal Disorders	26.2%
24	Adrenoleukodystrophy	25.9%
25	Dystonia Musculorum Deformans	25.2%
26	Galactosemias	25%
27	Urea Cycle Disorders, Inborn	25%
28	Tyrosinemias	25%
29	Leigh Disease	24.6%
30	Lafora Disease	24.4%
31	Unverricht-Lundborg Syndrome	24.4%
32	Myotonia Congenita	24.2%
33	Niemann-Pick Disease, Type C	24.1%
34	Myotonic Dystrophy	24.1%
35	Tay-Sachs Disease	23.7%
36	Mucopolysaccharidosis II	23.1%
37	Tuberous Sclerosis	22.8%
38	Werner Syndrome	22.6%
39	Pseudohypoparathyroidism	22.5%
40	Hypoalphalipoproteinemias	22.3%
41	Hyperphosphaturia	22.2%
42	Friedreich Ataxia	22.2%
43	Alstrom Syndrome	22.1%
44	Glycogen storage disease type II	21.6%
45	Cytochrome-c Oxidase Deficiency	21.5%
46	Optic Atrophy, Hereditary, Leber	21.4%
47	Carbamoyl-Phosphate Synthase I Deficiency Disease	21%
48	Albinism	20.5%
49	Homocystinuria	20.3%
50	Ichthyosis, X-Linked	20%
51	Zellweger Syndrome	19.9%
52	Hyperhomocysteinemia	19.6%
53	Huntington Disease	19.6%
54	Fragile X Syndrome	19.2%
55	Lactose Intolerance	19%
56	Charcot-Marie-Tooth Disease	18.6%
57	Lipodystrophy	18.4%
58	Wasting Syndrome	18.1%
59	Aicardi's syndrome	17.5%
60	Rett Syndrome	16.8%
61	Myasthenic Syndromes, Congenital	16.7%
62	Mucopolysaccharidosis III	16.7%
63	Alkaptonuria	16.7%
64	Glycogen Storage Disease	16.7%
65	Hypophosphatasia	16.7%
66	Propionic acidemia	16.7%
67	Dihydropyrimidine Dehydrogenase Deficiency	16.7%
68	Cystinosis	16.7%
69	Ataxia Telangiectasia	16.2%
70	Cystic Fibrosis	15.8%
71	CHARGE Syndrome	15.7%
72	Familial Hypophosphatemic Rickets	15.7%
73	Acid-Base Imbalance	15.7%
74	Calcium Metabolism Disorders	15.7%
75	Iron Metabolism Disorders	15.7%
76	Phosphorus Metabolism Disorders	15.7%
77	Water-Electrolyte Imbalance	15.7%
78	Mitochondrial Diseases	15.7%
79	Glucose Metabolism Disorders	15.7%
80	Xanthomatosis	15.5%
81	Dyslipidemias	15.5%
82	Xanthoma	15.5%
83	Hypercalcemia	15.4%
84	Hypocalcemia	15.4%
85	Milk-Alkali Syndrome	15.4%
86	Brain Diseases, Metabolic	15.3%
87	Neoplastic Syndromes, Hereditary	15.3%
88	Renal tubular acidosis	15%
89	Muscular Dystrophy, Duchenne	15%
90	Multiple Epiphyseal Dysplasia	14.9%
91	Osteochondrodysplasias	14.9%
92	Pelger-Huet Anomaly	14.9%
93	Familial Periodic Paralysis	14.6%
94	Muscular Dystrophy	14.2%
95	Anemia, Sickle Cell	14.2%
96	Thalassemia	14.2%
97	Smith-Magenis syndrome	14.2%
98	MELAS Syndrome	14.1%
99	Nail-Patella Syndrome	14.1%
100	Amyotrophic Lateral Sclerosis	13.9%
101	Osteopenia	13.6%
102	Lipomatosis	13.4%
103	Dwarfism	13.3%
104	Beckwith-Wiedemann Syndrome	13.3%
105	Wolf-Hirschhorn Syndrome	13.3%
106	Porphyrias, Hepatic	13.2%
107	Antley-Bixler Syndrome Phenotype	13.1%
108	Fanconi Anemia	13%
109	Osteogenesis Imperfecta	13%
110	Renal Aminoacidurias	12.9%
111	Fanconi Syndrome	12.9%
112	Pseudohypoaldosteronism	12.9%
113	Liddle Syndrome	12.9%
114	Cri-du-Chat Syndrome	12.9%
115	Down Syndrome	12.9%
116	Trisomy 21	12.9%
117	Prader-Willi Syndrome	12.7%
118	Rickets	12.7%
119	Glycosuria, Renal	12.5%
120	Holoprosencephaly	12.4%
121	Kartagener Syndrome	12.3%
122	Glycogen Storage Disease Type I	12%
123	Glycogen Storage Disease Type V	12%
124	Gout	11.8%
125	Marfan Syndrome	11.8%
126	Autoimmune Lymphoproliferative Syndrome	11.7%
127	Wiskott-Aldrich Syndrome	11.6%
128	Congenital Hyperinsulinism	11.6%
129	Angioedemas, Hereditary	11.5%
130	Motor Neuron Disease	11.4%
131	Rubinstein-Taybi Syndrome	10.9%
132	Xeroderma Pigmentosum	10.8%
133	Mitochondrial Encephalomyopathies	10.7%
134	Bloom Syndrome	10.7%
135	Ectodermal Dysplasia	10.7%
136	Aplasia Cutis Congenita	10.7%
137	Multiple System Atrophy	10.6%
138	Familial Mediterranean Fever	10.6%
139	Myelinolysis, Central Pontine	10.5%
140	Williams Syndrome	10.5%
141	Hypokalemic periodic paralysis	10.4%
142	Deformity	10.4%
143	Kallmann Syndrome	10.4%
144	Prion Diseases	10.4%
145	Tauopathies	9.9%
146	Subacute Combined Degeneration	9.9%
147	Nutrition Disorders	9.8%
148	Sickle Cell Trait	9.7%
149	Parkinson Disease	9.6%
150	Polycystic Kidney Diseases	9.4%
151	Cystinuria	9.3%
152	Primary Ciliary Dyskinesia	9.1%
153	Fetal Diseases	9%
154	Acidosis	9%
155	Alkalosis	9%
156	Amyloidosis	9%
157	Calcinosis	9%
158	Hyperglycemia	9%
159	Hyperinsulinism	9%
160	Hyperkalemia	9%
161	Hypernatremia	9%
162	Hypoglycemia	9%
163	Hypokalemia	9%
164	Hyponatremia	9%
165	Hypophosphatemia	9%
166	Metabolic acidosis	9%
167	Iron Overload	9%
168	Welander Distal Myopathy	8.9%
169	Retinal Dysplasia	8.7%
170	Duane Retraction Syndrome	8.7%
171	Lewy Body Disease	8.7%
172	Aniridia	8.7%
173	Variegate Porphyria	8.7%
174	Acute intermittent porphyria	8.7%
175	Porphyria Cutanea Tarda	8.7%
176	Adiposis Dolorosa	8.6%
177	Epidermolysis Bullosa	8.6%
178	HIV-Associated Lipodystrophy Syndrome	8.5%
179	Mitochondrial Myopathies	8.5%
180	Arthritis, Gouty	8.4%
181	Classical Lissencephalies and Subcortical Band Heterotopias	8.2%
182	Spinal Muscular Atrophy	8.2%
183	Progressive Muscular Atrophy	8.2%
184	Osteomalacia	8.2%
185	Acute Chest Syndrome	8.1%
186	Cutis Laxa	8.1%
187	Retinitis Pigmentosa	8%
188	Pigmentary retinopathy	8%
189	Porokeratosis	8%
190	Keratoderma, Palmoplantar	8%
191	Chronic granulomatous disease	8%
192	Reye Syndrome	8%
193	Diabetes Mellitus	7.9%
194	Hepatic Encephalopathy	7.9%
195	Kernicterus	7.8%
196	Neuronal Ceroid-Lipofuscinoses	7.8%
197	Dehydration	7.8%
198	Water Intoxication	7.8%
199	Nesidioblastosis	7.8%
200	Mobius Syndrome	7.7%
201	Achlorhydria	7.7%
202	Osteoporosis	7.7%
203	Bone Demineralization, Pathologic	7.7%
204	Post-Traumatic Osteoporosis	7.7%
205	Celiac Disease	7.7%
206	Sprue, Tropical	7.7%
207	Steatorrhea	7.7%
208	Sprue	7.7%
209	Paraneoplastic Encephalomyelitis	7.5%
210	Progressive bulbar palsy	7.5%
211	Bulbar palsy	7.5%
212	Lipid Metabolism Disorders	7.4%
213	Striatonigral Degeneration	7.4%
214	Diabetic Ketoacidosis	7.3%
215	Hypercholesterolemia	7.3%
216	Hyperlipoproteinemias	7.3%
217	Hypertriglyceridemia	7.3%
218	HIV Wasting Syndrome	7.2%
219	Pseudoxanthoma Elasticum	7.2%
220	Peutz-Jeghers Syndrome	7.1%
221	Thrombasthenia	7.1%
222	Antithrombin III Deficiency	7.1%
223	Protein C Deficiency	7.1%
224	Afibrinogenemia	7.1%
225	Factor VII Deficiency	7.1%
226	Factor X Deficiency	7.1%
227	Factor XII Deficiency	7.1%
228	Hemophilia A	7.1%
229	Activated Protein C Resistance	7.1%
230	Factor II deficiency	7.1%
231	Factor VIII Deficiency	7.1%
232	Factor V deficiency	7.1%
233	Factor XI Deficiency	7.1%
234	Hypoprothrombinemias	7.1%
235	Meconium Aspiration Syndrome	7%
236	Anemia, Diamond-Blackfan	7%
237	Wernicke Encephalopathy	6.9%
238	Frontotemporal dementia	6.8%
239	Progressive supranuclear palsy	6.8%
240	Kearns-Sayre syndrome	6.8%
241	Dandy-Walker Syndrome	6.8%
242	Glycosuria	6.7%
243	Shy-Drager Syndrome	6.7%
244	Lambert-Eaton Myasthenic Syndrome	6.6%
245	Multiple Endocrine Neoplasia	6.5%
246	Myelitis, Transverse	6.5%
247	Polycystic Kidney, Autosomal Dominant	6.4%
248	Congenital Hypothyroidism	6.4%
249	Dermatitis, Atopic	6.4%
250	Opsoclonus-Myoclonus Syndrome	6.3%
251	Hyperkeratosis, Epidermolytic	6.3%
252	Xeroderma	6.2%
253	Dural Arteriovenous Fistula	6.2%
254	Scrapie	6.2%
255	Renal Osteodystrophy	6.1%
256	Renal rickets	6.1%
257	Anencephaly	6.1%
258	Presenile dementia	6.1%
259	Senile dementia	6.1%
260	Basal Cell Nevus Syndrome	6.1%
261	Central Nervous System Cysts	6%
262	Necrobiosis Lipoidica Diabeticorum	6%
263	Stiff-Person Syndrome	5.9%
264	Hydranencephaly	5.9%
265	Neural Tube Defects	5.9%
266	Tethered Cord Syndrome	5.9%
267	Iniencephaly	5.9%
268	Craniorachischisis	5.9%
269	Exencephaly	5.9%
270	Septo-Optic Dysplasia	5.9%
271	Cortical Dysplasia	5.9%
272	Malformations of Cortical Development	5.9%
273	Tetany	5.9%
274	Limbic Encephalitis	5.9%
275	Behcet Syndrome	5.8%
276	Abdominal Cramps	5.8%
277	Abnormalities, Drug-Induced	5.8%
278	Amniotic Band Syndrome	5.8%
279	Asphyxia Neonatorum	5.8%
280	Infant, Premature, Diseases	5.8%
281	Situs Inversus	5.8%
282	Infantile Colic	5.8%
283	Acidosis, Lactic	5.7%
284	Calciphylaxis	5.7%
285	Hemosiderosis	5.7%
286	Ketosis	5.7%
287	Ketonuria	5.7%
288	Ketoacidosis	5.7%
289	Ketonemia	5.7%
290	Vascular calcification	5.7%
291	Restless Legs Syndrome	5.7%
292	Cranial nerve diseases	5.6%
293	Demyelinating Diseases	5.6%
294	Demyelination	5.6%
295	Neuromuscular Diseases	5.6%
296	Chronobiology Disorders	5.6%
297	Congenital nystagmus	5.6%
298	Ophthalmoplegic Migraine	5.5%
299	Polyradiculoneuropathy	5.5%
300	Polyradiculoneuritis	5.5%
301	Papillon-Lefevre Disease	5.5%
302	Paraneoplastic Cerebellar Degeneration	5.4%
303	Toxoplasmosis, Congenital	5.3%
304	Child Nutrition Disorders	5.2%
305	Hypervitaminosis A	5.2%
306	Infant Nutrition Disorders	5.2%
307	Malnutrition	5.2%
308	Cerebral Amyloid Angiopathy	5.1%
309	Ocular Motility Disorders	5.1%
310	Cyclophoria	5.1%
311	Eye Abnormalities	5.1%
312	Cardiovascular Abnormalities	5.1%
313	Meningoencephalitis	5.1%
314	Skin Abnormalities	5%
315	Lymphatic Abnormalities	5%
316	Congenital Microtia	5%
317	Anemia, Neonatal	5%
318	Persistent Fetal Circulation Syndrome	5%
319	Trauma, Nervous System	5%
320	Congenital diaphragmatic hernia	4.9%
321	Umbilical hernia	4.9%
322	Nephroblastoma	4.9%
323	Acidosis, Respiratory	4.9%
324	Alkalosis, Respiratory	4.9%
325	Insulin Resistance	4.9%
326	Osteoporosis, Postmenopausal	4.9%
327	Nervous System Neoplasms	4.9%
328	Neurologic Manifestations	4.9%
329	Neurotoxicity Syndromes	4.9%
330	Guillain-Barre Syndrome	4.7%
331	Encephalomyelitis	4.7%
332	Autonomic Dysreflexia	4.7%
333	Complex Regional Pain Syndromes	4.7%
334	Klinefelter Syndrome	4.7%
335	Leukoencephalitis, Acute Hemorrhagic	4.7%
336	Hydrops Fetalis	4.6%
337	Miller Fisher Syndrome	4.6%
338	Turner Syndrome	4.6%
339	Leukomalacia, Periventricular	4.5%
340	Adenomatous Polyposis Coli	4.5%
341	Urogenital Abnormalities	4.5%
342	Multiple Endocrine Neoplasia Type 1	4.4%
343	Neonatal Abstinence Syndrome	4.4%
344	Pneumocephalus	4.4%
345	Poliomyelitis	4.4%
346	Gestational Diabetes	4.4%
347	Latent Autoimmune Diabetes in Adults	4.4%
348	Fetal Growth Retardation	4.3%
349	Diabetes Mellitus, Experimental	4.3%
350	Fetal Hypoxia	4.3%
351	Fetal Alcohol Spectrum Disorders	4.3%
352	Sleep Wake Disorders	4.3%
353	Syphilis, Congenital	4.3%
354	Nephrocalcinosis	4.3%
355	Neuromyelitis Optica	4.3%
356	Spinal Cord Injuries	4.2%
357	Marchiafava-Bignami Disease	4.2%
358	Peripheral Nerve Injuries	4.2%
359	Myasthenia Gravis	4.1%
360	Asterixis	4.1%
361	Ballismus	4.1%
362	Causalgia	4.1%
363	Maxillofacial Abnormalities	4%
364	Dextrocardia	4%
365	Epidural Abscess	4%
366	Olfactory Nerve Injuries	4%
367	Microcephaly	4%
368	Macrocephaly	4%
369	Meningomyelocele	4%
370	Spina Bifida	4%
371	Dyskinesia, Drug-Induced	3.9%
372	MPTP Poisoning	3.9%
373	Chorioamnionitis	3.8%
374	Leukoencephalopathy, Progressive Multifocal	3.8%
375	Primary amyloidosis	3.8%
376	Encephalomyelitis, Acute Disseminated	3.8%
377	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3.8%
378	Chronic Fatigue Syndrome	3.8%
379	Sleep Disorders, Circadian Rhythm	3.8%
380	Myelitis	3.7%
381	Neuroleptic Malignant Syndrome	3.7%
382	Botulism	3.7%
383	Facial Nerve Injuries	3.6%
384	Porencephaly	3.6%
385	Lupus Vasculitis, Central Nervous System	3.5%
386	Prune Belly Syndrome	3.5%
387	Twins, Conjoined	3.5%
388	Waardenburg Syndrome	3.5%
389	Meningocele	3.5%
390	Encephalocele	3.5%
391	Abnormalities, Radiation-Induced	3.5%
392	POEMS Syndrome	3.4%
393	Scimitar Syndrome	3.3%
394	Akathisia, Drug-Induced	3.3%
395	Brain Diseases	3.3%
396	Dysautonomia	3.3%
397	Meningitis	3.3%
398	Movement Disorders	3.3%
399	Pachymeningitis	3.3%
400	Spinal Cord Diseases	3.3%
401	Vagus Nerve Disorder	3.3%
402	Glossopharyngeal Neuralgia	3.3%
403	Abducens Nerve Diseases	3.3%
404	Heavy Metal Poisoning, Nervous System	3.3%
405	Neuromuscular Junction Diseases	3.3%
406	Trochlear Nerve Diseases	3.3%
407	Peripheral Nervous System Diseases	3.3%
408	Horner Syndrome	3.3%
409	Brain Injuries	3.3%
410	Brain Neoplasms	3.3%
411	Multiple Sclerosis	3.3%
412	Spinal Cord Neoplasms	3.3%
413	Reflex Sympathetic Dystrophy	3.3%
414	Subdural Effusion	3.3%
415	Parkinsonian Disorders	3.3%
416	Nocturnal Myoclonus Syndrome	3.3%
417	Myasthenia Gravis, Autoimmune, Experimental	3.3%
418	Epilepsy, Post-Traumatic	3.2%
419	Denys-Drash Syndrome	3.2%
420	Ophthalmia Neonatorum	3.1%
421	CREST Syndrome	3.1%
422	Anophthalmos	3.1%
423	Anus, Imperforate	3.1%
424	Microphthalmos	3.1%
425	Paralysis, Obstetric	3.1%
426	Retinopathy of Prematurity	3.1%
427	Limb Deformities, Congenital	3.1%
428	Craniofacial Abnormalities	3.1%
429	Anorectal Malformations	3.1%
430	Dementia, Vascular	3%
431	Bronchopulmonary Dysplasia	3%
432	Brain Hemorrhage, Traumatic	3%
433	Dermal Sinus	3%
434	Spina Bifida Cystica	3%
435	Spina Bifida Occulta	3%
436	Lissencephaly	3%
437	Polymicrogyria	3%
438	Pachygyria	3%
439	Schizencephaly	3%
440	Periventricular Nodular Heterotopia	3%
441	Acrocephalosyndactylia	3%
442	Deficiency Diseases	3%
443	Starvation	3%
444	Refeeding Syndrome	3%
445	Vasculitis, Central Nervous System	3%
446	Jet Lag Syndrome	3%
447	Brain Abscess	2.9%
448	Ophthalmoplegia	2.9%
449	External Ophthalmoplegia	2.9%
450	Craniosynostosis	2.9%
451	Syndactyly	2.9%
452	Brachycephaly	2.9%
453	Central Nervous System Infection	2.9%
454	Myopathy	2.9%
455	Optic Neuropathy	2.9%
456	Central Cord Syndrome	2.9%
457	Cerebellar Neoplasms	2.9%
458	Facial Nerve Diseases	2.9%
459	Craniocerebral Trauma	2.9%
460	Parasomnia	2.9%
461	Meningitis, Bacterial	2.9%
462	Meningitis, Fungal	2.9%
463	Dyssomnias	2.9%
464	Chorea	2.8%
465	Acrodynia	2.8%
466	Vestibulocochlear Nerve Diseases	2.8%
467	Decerebrate State	2.8%
468	Hemiparesis	2.8%
469	Meningism	2.8%
470	Paresis	2.8%
471	Seizures	2.8%
472	Sensation Disorders	2.8%
473	Central Nervous System Neoplasms	2.8%
474	Complex partial seizures	2.8%
475	Monoparesis	2.8%
476	Neurogenic Inflammation	2.8%
477	Gait Disorders, Neurologic	2.8%
478	Neuromuscular Manifestations	2.8%
479	Sweating, Gustatory	2.8%
480	Auriculotemporal Syndrome	2.8%
481	Meige Syndrome	2.8%
482	Brachial Plexus Neuritis	2.8%
483	Neuralgic Amyotrophy	2.8%
484	Cerebral Ventriculitis	2.8%
485	Blepharophimosis	2.7%
486	Laryngostenosis	2.7%
487	Mouth Abnormalities	2.7%
488	Respiratory Distress Syndrome, Newborn	2.7%
489	Noonan Syndrome	2.7%
490	Esophageal Atresia	2.7%
491	Intestinal Atresia	2.7%
492	Horseshoe Kidney	2.7%
493	Pectus excavatum	2.7%
494	Klippel-Feil Syndrome	2.7%
495	Gastroschisis	2.7%
496	Synostosis	2.7%
497	Acrodermatitis	2.7%
498	Lymphangiectasis, Intestinal	2.7%
499	Gianotti-Crosti Syndrome	2.7%
500	Vocal Cord Paralysis	2.7%
501	Carotid Artery Injuries	2.7%
502	Tuberculosis, Meningeal	2.6%
503	Cleft Palate	2.6%
504	Amblyopia	2.6%
505	Brain Death	2.5%
506	Coma, Post-Head Injury	2.5%
507	Pupil Disorders	2.5%
508	Neurobehavioral Manifestations	2.5%
509	Tarsal Tunnel Syndrome	2.5%
510	Cauda Equina Syndrome	2.5%
511	Posterior Leukoencephalopathy Syndrome	2.5%
512	Posterior reversible encephalopathy syndrome	2.5%
513	Cerebrospinal Fluid Otorrhea	2.5%
514	Cerebrospinal Fluid Rhinorrhea	2.5%
515	Neuritis, Autoimmune, Experimental	2.5%
516	Gait Ataxia	2.5%
517	Uveomeningoencephalitic Syndrome	2.5%
518	Sturge-Weber Syndrome	2.5%
519	Vertigo	2.5%
520	Alcohol-Induced Disorders, Nervous System	2.5%
521	Optic Nerve Glioma	2.5%
522	Creutzfeldt-Jakob disease	2.4%
523	Basal Ganglia Cerebrovascular Disease	2.4%
524	Brain Injuries, Diffuse	2.4%
525	Traumatic Brain Injury	2.4%
526	Arthrogryposis	2.4%
527	Choanal Atresia	2.4%
528	Tracheobronchomegaly	2.4%
529	Laryngocele	2.4%
530	Cerebellar Ataxia	2.4%
531	Supratentorial Neoplasms	2.4%
532	Torticollis	2.4%
533	Multiple Sclerosis, Chronic Progressive	2.4%
534	Multiple Sclerosis, Relapsing-Remitting	2.4%
535	Alice in Wonderland Syndrome	2.4%
536	Choledochal Cyst	2.4%
537	Hermaphroditism	2.4%
538	Disorders of Sex Development	2.4%
539	Jaw Abnormalities	2.4%
540	Cryptorchidism	2.4%
541	Hypospadias	2.4%
542	Pituitary Adenoma	2.4%
543	Pituitary Neoplasms	2.4%
544	Alcohol Withdrawal Seizures	2.4%
545	Brain Concussion	2.3%
546	Myoclonic Epilepsy	2.3%
547	Epilepsy, Temporal Lobe	2.3%
548	Epilepsy, Rolandic	2.3%
549	Benign Rolandic Epilepsy	2.3%
550	Toxoplasmosis, Cerebral	2.3%
551	Akathisia	2.3%
552	Restlessness	2.3%
553	Psychomotor Agitation	2.3%
554	Poland Syndrome	2.3%
555	Voice Disorders	2.2%
556	Voice Disturbance	2.2%
557	Carpal Tunnel Syndrome	2.2%
558	Vascular Headaches	2.2%
559	neurofibroma	2.2%
560	Hypoxia-Ischemia, Brain	2.2%
561	Sciatica	2.2%
562	Tardive Dyskinesia	2.2%
563	Persistent Vegetative State	2.2%
564	Laryngomalacia	2.2%
565	Akinetic Mutism	2.2%
566	Anoxic Encephalopathy	2.2%
567	Arachnoiditis	2.2%
568	Basal Ganglia Diseases	2.2%
569	Brain Damage, Chronic	2.2%
570	Cerebellar Diseases	2.2%
571	Encephalitis	2.2%
572	Encephalomalacia	2.2%
573	Epilepsy	2.2%
574	Hydrocephalus	2.2%
575	Congenital Hydrocephalus	2.2%
576	Hypothalamic Diseases	2.2%
577	Aseptic Meningitis	2.2%
578	Neuritis	2.2%
579	Polyneuritis	2.2%
580	Radiculitis	2.2%
581	Syringomyelia	2.2%
582	Thalamic Diseases	2.2%
583	Intracranial Hypertension	2.2%
584	Polyneuropathy	2.2%
585	Mononeuritis	2.2%
586	Aura	2.2%
587	Leukoencephalopathy	2.2%
588	Essential Tremor	2.2%
589	Neuroaxonal Dystrophies	2.2%
590	Familial Tremor	2.2%
591	Headache Disorders	2.2%
592	Mononeuropathies	2.2%
593	Intracranial Hypotension	2.2%
594	Brachial Plexus Neuropathies	2.2%
595	Radiculopathy	2.2%
596	Mononeuropathy Multiplex	2.2%
597	Nerve Root Compression	2.2%
598	Brain Edema	2.2%
599	Brain Hypoxia	2.2%
600	Aqueductal Stenosis	2.2%
601	Pneumorrhachis	2.2%
602	Writer's Cramp	2.2%
603	Pectus carinatum	2.2%
604	Bladder Exstrophy	2.1%
605	Epispadias	2.1%
606	Multicystic Dysplastic Kidney	2.1%
607	Basal Ganglia Hemorrhage	2.1%
608	Vertebral Artery Dissection	2.1%
609	Amnesia, Transient Global	2.1%
610	Gait Apraxia	2.1%
611	Amelia	2.1%
612	Arachnodactyly	2.1%
613	Ectopia Cordis	2.1%
614	Ectromelia	2.1%
615	Hemimelia	2.1%
616	Phocomelia	2.1%
617	Sirenomelia	2.1%
618	Polydactyly	2.1%
619	Brachydactyly	2.1%
620	Plagiocephaly	2.1%
621	Lower Extremity Deformities, Congenital	2.1%
622	Upper Extremity Deformities, Congenital	2.1%
623	Single umbilical artery	2.1%
624	Juvenile Myoclonic Epilepsy	2.1%
625	Myoclonic Epilepsies, Progressive	2.1%
626	Cubital Tunnel Syndrome	2%
627	Diffuse Axonal Injury	2%
628	Brain Stem Neoplasms	2%
629	Subarachnoid Hemorrhage, Traumatic	2%
630	Carotid Artery, Internal, Dissection	2%
631	Meningitis, Cryptococcal	2%
632	Subacute Sclerosing Panencephalitis	2%
633	Meningitis, Listeria	2%
634	Obesity	2%
635	Meningitis, Haemophilus	2%
636	Meningitis, Pneumococcal	2%
637	Reflex, Abnormal	2%
638	Hyporeflexia	2%
639	Hyperreflexia	2%
640	Putaminal Hemorrhage	1.9%
641	Micrognathism	1.9%
642	Pierre Robin Syndrome	1.9%
643	Kwashiorkor	1.9%
644	Magnesium Deficiency	1.9%
645	Potassium Deficiency	1.9%
646	Protein Deficiency	1.9%
647	Avitaminosis	1.9%
648	Cerebrovascular Disorders	1.9%
649	Myositis	1.9%
650	Optic Atrophy	1.9%
651	Optic Neuritis	1.9%
652	Papilledema	1.9%
653	Strabismus	1.9%
654	Tolosa-Hunt Syndrome	1.9%
655	Cerebrovascular Insufficiency	1.9%
656	Isaacs syndrome	1.9%
657	Arsenic Poisoning	1.9%
658	Dementia	1.9%
659	Myotonic Disorders	1.9%
660	Central Nervous System Fungal Infections	1.9%
661	Infarction, Middle Cerebral Artery	1.9%
662	Conus Medullaris Syndrome	1.9%
663	Infarction, Anterior Cerebral Artery	1.9%
664	Spinal Cord Vascular Diseases	1.9%
665	Infarction, Posterior Cerebral Artery	1.9%
666	Diabetic Neuropathies	1.9%
667	Facial Injuries	1.9%
668	Facial Neuralgia	1.9%
669	Diabetic Amyotrophy	1.9%
670	Diabetic Autonomic Neuropathy	1.9%
671	Sleep Talking	1.9%
672	Manganese Poisoning	1.9%
673	Sleep Disorders, Intrinsic	1.9%
674	Orthostatic intolerance	1.9%
675	Anosmia	1.9%
676	Ataxia	1.9%
677	Athetosis	1.9%
678	Catalepsy	1.9%
679	Dystonia	1.9%
680	Hemiplegia	1.9%
681	Locked-In Syndrome	1.9%
682	Meningeal Neoplasms	1.9%
683	Muscle Hypertonia	1.9%
684	Muscle hypotonia	1.9%
685	Myoclonus	1.9%
686	Myotonia	1.9%
687	Neuralgia	1.9%
688	Paraplegia	1.9%
689	Pseudobulbar Palsy	1.9%
690	Quadriplegia	1.9%
691	Spasm	1.9%
692	Spastic Paraplegia	1.9%
693	Status Epilepticus	1.9%
694	Taste Disorders	1.9%
695	Tremor	1.9%
696	Monoplegia	1.9%
697	Hypokinesia	1.9%
698	Paraparesis	1.9%
699	Bradykinesia	1.9%
700	Waxy flexibility	1.9%
701	Action Tremor	1.9%
702	Resting Tremor	1.9%
703	Dysosmia	1.9%
704	Quadriparesis	1.9%
705	Mercury Poisoning, Nervous System	1.9%
706	Olfaction Disorders	1.9%
707	Myokymia	1.9%
708	Lead Poisoning, Nervous System	1.9%
709	Vestibular Neuronitis	1.9%
710	Somatosensory Disorders	1.9%
711	Neuropathic pain	1.9%
712	Hyperkinesia	1.9%
713	Intention tremor	1.9%
714	Acoustic Neuroma	1.9%
715	Aortic coarctation	1.8%
716	Cor Triatriatum	1.8%
717	Coronary Vessel Anomalies	1.8%
718	Dental Enamel Hypoplasia	1.8%
719	Patent ductus arteriosus	1.8%
720	Ebstein Anomaly	1.8%
721	Heart Septal Defects	1.8%
722	Hyaline Membrane Disease	1.8%
723	Hypodontia	1.8%
724	Macrostomia	1.8%
725	Microstomia	1.8%
726	Tetralogy of Fallot	1.8%
727	Transposition of Great Vessels	1.8%
728	Hypoplastic Left Heart Syndrome	1.8%
729	May-Thurner Syndrome	1.8%
730	Craniofacial Dysostosis	1.8%
731	Wolff-Parkinson-White Syndrome	1.8%
732	Pituitary Apoplexy	1.8%
733	Choroid Plexus Papilloma	1.8%
734	Brain Contusion	1.8%
735	Brain Infarction	1.8%
736	Auditory Perceptual Disorders	1.8%
737	Giant Cell Arteritis	1.8%
738	Temporal Arteritis	1.8%
739	Retrognathia	1.8%
740	Hyperandrogenism	1.7%
741	Hand-Arm Vibration Syndrome	1.7%
742	Vision Disorders	1.7%
743	Metamorphopsia	1.7%
744	Visual Impairment	1.7%
745	Fibromyalgia	1.7%
746	Optic Neuropathy, Ischemic	1.7%
747	Anterior Ischemic Optic Neuropathy	1.7%
748	Central Nervous System Bacterial Infections	1.7%
749	Medial Tibial Stress Syndrome	1.7%
750	Facial Hemiatrophy	1.7%
751	Melkersson-Rosenthal Syndrome	1.7%
752	West Nile Fever	1.7%
753	Anisocoria	1.6%
754	Confusion	1.6%
755	Facial paralysis	1.6%
756	Lethargy	1.6%
757	Memory Disorders	1.6%
758	Muscle Cramp	1.6%
759	Perceptual Disorders	1.6%
760	Psychomotor Disorders	1.6%
761	Tonic Pupil	1.6%
762	Eosinophilia-Myalgia Syndrome	1.6%
763	Anhedonia	1.6%
764	Disorientation	1.6%
765	Facial Paresis	1.6%
766	Memory Loss	1.6%
767	Hemisensory Neglect	1.6%
768	Dysacusis	1.6%
769	Sleep Bruxism	1.6%
770	Long QT Syndrome	1.6%
771	Platybasia	1.6%
772	Tricuspid Atresia	1.6%
773	Arrhythmogenic Right Ventricular Dysplasia	1.6%
774	Muscular Atrophy	1.6%
775	Respiratory Paralysis	1.6%
776	Gonadal Dysgenesis	1.6%
777	Bronchomalacia	1.6%
778	Adrenogenital Syndrome	1.6%
779	Tracheomalacia	1.6%
780	Ovotesticular Disorders of Sex Development	1.6%
781	Prognathism	1.6%
782	Cerebral Palsy	1.6%
783	Epilepsies, Partial	1.6%
784	Epilepsy, Generalized	1.6%
785	Pseudotumor Cerebri	1.6%
786	Sciatic Neuropathy	1.6%
787	Hypertensive Encephalopathy	1.6%
788	Ulnar Neuropathies	1.6%
789	Lesion of Sciatic Nerve	1.6%
790	Simple Partial Seizures	1.6%
791	Epilepsy, Reflex	1.6%
792	Ulnar Neuritis	1.6%
793	Radial nerve compression	1.6%
794	Radial Tunnel Syndrome	1.6%
795	Peroneal Neuropathies	1.6%
796	Radial Neuropathy	1.6%
797	Median Neuropathy	1.6%
798	Sciatic Nerve Palsy	1.6%
799	Femoral Neuropathy	1.6%
800	Tibial Neuropathy	1.6%
801	Ulnar Nerve Palsy	1.6%
802	Postural Orthostatic Tachycardia Syndrome	1.6%
803	Radial nerve palsy	1.6%
804	Headache Disorders, Primary	1.6%
805	Headache Disorders, Secondary	1.6%
806	Medication overuse headache	1.6%
807	Alexia	1.6%
808	Dyslexia	1.6%
809	Cerebral Infarction	1.6%
810	Brain Stem Infarctions	1.6%
811	Hematoma, Subdural	1.5%
812	Hematoma, Epidural, Cranial	1.5%
813	Moyamoya Disease	1.5%
814	Neurofibrosarcoma	1.5%
815	Lateral Medullary Syndrome	1.5%
816	Consciousness Disorders	1.5%
817	Mental Retardation	1.5%
818	Muscle Weakness	1.5%
819	Depressed Level of Consciousness	1.5%
820	Mental deficiency	1.5%
821	Intellectual Disability	1.5%
822	Bell Palsy	1.5%
823	Catatonia	1.5%
824	Herpes Zoster Oticus	1.5%
825	Aphonia	1.5%
826	Sleep Deprivation	1.5%
827	Dysphonia	1.5%
828	Pituitary Diseases	1.4%
829	Aortopulmonary Septal Defect	1.4%
830	Double Outlet Right Ventricle	1.4%
831	Endocardial Cushion Defects	1.4%
832	Myocardial bridging	1.4%
833	Aorticopulmonary Septal Defect	1.4%
834	Thoracic Outlet Syndrome	1.4%
835	Obesity, Abdominal	1.4%
836	Carotid Artery Diseases	1.4%
837	Brain Ischemia	1.4%
838	Esotropia	1.4%
839	Exotropia	1.4%
840	Hypotension, Orthostatic	1.4%
841	Sleep Apnea Syndromes	1.4%
842	Cerebrovascular accident	1.4%
843	Polymyositis	1.4%
844	Kluver-Bucy Syndrome	1.4%
845	Vasospasm, Intracranial	1.4%
846	Spinal Cord Ischemia	1.4%
847	Intracranial Arterial Diseases	1.4%
848	Post-Exercise Hypotension	1.4%
849	Disorders of Excessive Somnolence	1.4%
850	Sleep Initiation and Maintenance Disorders	1.4%
851	Night Terrors	1.4%
852	Somnambulism	1.4%
853	Trigeminal Nerve Disorder	1.4%
854	Transient Insomnia	1.4%
855	Sleep Paralysis	1.4%
856	Chronic Insomnia	1.4%
857	REM Sleep Behavior Disorder	1.4%
858	Hypersomnia	1.4%
859	Dysgeusia	1.4%
860	Formication	1.4%
861	Hyperalgesia	1.4%
862	Hyperesthesia	1.4%
863	Hypesthesia	1.4%
864	Language Disorders	1.4%
865	Numbness	1.4%
866	Paresthesia	1.4%
867	Paraparesis, Spastic	1.4%
868	Trismus	1.4%
869	Epilepsia Partialis Continua	1.4%
870	Hypogeusia	1.4%
871	Meningeal Carcinomatosis	1.4%
872	Brown-Sequard Syndrome	1.4%
873	Lockjaw	1.4%
874	Allodynia	1.4%
875	Lead Poisoning, Nervous System, Childhood	1.4%
876	Lead Poisoning, Nervous System, Adult	1.4%
877	Ageusia	1.4%
878	Tuberculosis, Central Nervous System	1.4%
879	Ascorbic Acid Deficiency	1.3%
880	Polyradiculopathy	1.3%
881	Post-Traumatic Headache	1.3%
882	Tension Headache	1.3%
883	Vitamin A Deficiency	1.3%
884	Vitamin D Deficiency	1.3%
885	Vitamin E Deficiency	1.3%
886	Epilepsy, Complex Partial	1.3%
887	Marasmus	1.3%
888	Migraine Disorders	1.3%
889	Abdominal Migraine	1.3%
890	Status Migrainosus	1.3%
891	Cervicogenic Headache	1.3%
892	Hematoma, Subdural, Intracranial	1.3%
893	Hematoma, Subdural, Chronic	1.3%
894	Hematoma, Subdural, Acute	1.3%
895	Myalgia	1.3%
896	Mandibulofacial Dysostosis	1.3%
897	Romano-Ward Syndrome	1.3%
898	Eye Injuries	1.3%
899	Pediatric Obesity	1.2%
900	Orbital Myositis	1.2%
901	Diplopia	1.2%
902	Muscle Rigidity	1.2%
903	Muscle Spasticity	1.2%
904	Scotoma	1.2%
905	Photophobia	1.2%
906	Cogwheel Rigidity	1.2%
907	Hemifacial Spasm	1.2%
908	Amaurosis	1.2%
909	Blindness	1.2%
910	Nuchal Rigidity	1.2%
911	Neuroaspergillosis	1.2%
912	Pyomyositis	1.2%
913	Intracranial Embolism and Thrombosis	1.2%
914	Agnosia	1.2%
915	Apraxias	1.2%
916	Hallucinations	1.2%
917	Hemianopsia	1.2%
918	Hyperacusis	1.2%
919	Tinnitus	1.2%
920	Visual Agnosia	1.2%
921	Anosognosia	1.2%
922	Wernicke-Korsakoff Syndrome	1.2%
923	Phonophobia	1.2%
924	Hearing Loss	1.2%
925	Sarcopenia	1.2%
926	Cluster Headache	1.2%
927	Migraine with Aura	1.2%
928	Familial Hemiplegic Migraine	1.2%
929	Chronic Paroxysmal Hemicrania	1.2%
930	SUNCT Syndrome	1.2%
931	Paroxysmal Hemicrania	1.2%
932	Truncus Arteriosus, Persistent	1.2%
933	Goldenhar Syndrome	1.2%
934	Hoarseness	1.2%
935	Alcohol Withdrawal Delirium	1.2%
936	Empty Sella Syndrome	1.2%
937	Hyperpituitarism	1.2%
938	Hypopituitarism	1.2%
939	Hypophysitis	1.2%
940	Cerebral Arterial Diseases	1.2%
941	Vertebrobasilar Insufficiency	1.2%
942	Anterior Spinal Artery Syndrome	1.2%
943	Basilar Artery Stenosis	1.2%
944	Vertebral Artery Stenosis	1.2%
945	Sleep Apnea, Obstructive	1.2%
946	Sleep Apnea, Central	1.2%
947	Intracranial Hemorrhage, Hypertensive	1.2%
948	Transient Cerebral Ischemia	1.2%
949	Narcolepsy	1.2%
950	Trigeminal Neuralgia	1.2%
951	Kleine-Levin Syndrome	1.2%
952	Agraphia	1.2%
953	Anomia	1.2%
954	Cluttering	1.2%
955	Language Development Disorders	1.2%
956	Speech Disorders	1.2%
957	Syncope	1.2%
958	Stupor	1.2%
959	Dysgraphia	1.2%
960	Presyncope	1.2%
961	Dyslalia	1.2%
962	Pseudorabies	1.1%
963	Waterhouse-Friderichsen Syndrome	1.1%
964	Amnesia	1.1%
965	Delirium	1.1%
966	Dissociative Amnesia	1.1%
967	Color blindness	1.1%
968	Global Amnesia	1.1%
969	Meningioma	1.1%
970	Talipes	1.1%
971	Neurosyphilis	1.1%
972	Folic Acid Deficiency	1.1%
973	Pellagra	1.1%
974	Thiamine Deficiency	1.1%
975	Vitamin B 12 Deficiency	1.1%
976	Vitamin B 6 Deficiency	1.1%
977	Pyridoxine Deficiency	1.1%
978	Hyperprolactinemia	1%
979	Subclavian Steal Syndrome	1%
980	Pick Disease of the Brain	1%
981	Cataplexy	1%
982	Arteriovenous fistula	1%
983	Aphasia	1%
984	Articulation Disorders	1%
985	Echolalia	1%
986	Stuttering	1%
987	Dysphasia	1%
988	Eye Burns	1%
989	Malaria, Cerebral	1%
990	Vitamin K Deficiency	1%
991	Carotid Stenosis	1%
992	Intracranial Aneurysm	1%
993	Neurocysticercosis	1%
994	Amaurosis Fugax	1%
995	Blindness, Cortical	1%
996	Dyscalculia	1%
997	Intracranial Arteriosclerosis	1%
998	Cerebral Atherosclerosis	1%
999	Subarachnoid Hemorrhage	1%
1000	Cerebral Arteriosclerosis	1%
1001	Cerebral Hemorrhage	1%
1002	Cerebral Thrombosis	1%
1003	Intracranial Embolism	1%
1004	Intracranial Thrombosis	1%
1005	Deafness	1%
1006	Hearing Loss, Sudden	1%
1007	Gerstmann Syndrome	1%
1008	Hearing Loss, Bilateral	1%
1009	Hearing Loss, High-Frequency	1%
1010	Hearing Loss, Mixed Conductive-Sensorineural	1%
1011	Prosopagnosia	1%
1012	Apraxia, Ideomotor	1%
1013	Charles Bonnet Syndrome	1%
1014	Hearing Loss, Unilateral	1%
1015	Complete Hearing Loss	1%
1016	Alien Hand Syndrome	1%
1017	Deaf Mutism	1%
1018	Congenital clubfoot	1%
1019	Vertical Talus	1%
1020	AIDS Dementia Complex	1%
1021	Dysarthria	1%
1022	Phantom pain	1%
1023	Phantom Limb Pain	1%
1024	Lyme Neuroborreliosis	1%
1025	Beriberi	0.9%
1026	Dermatomyositis	0.9%
1027	Mutism	0.9%
1028	Selective Mutism	0.9%
1029	Corneal Scar	0.9%
1030	Acromegaly	0.9%
1031	Sinus Thrombosis, Intracranial	0.9%
1032	Retrograde amnesia	0.9%
1033	Amnesia, Anterograde	0.9%
1034	Carotid Artery Thrombosis	0.9%
1035	Alexia, Pure	0.9%
1036	Cavernous Sinus Thrombosis	0.9%
1037	Sagittal Sinus Thrombosis	0.9%
1038	Corneal Perforation	0.8%
1039	Scurvy	0.8%
1040	Anemia, Pernicious	0.8%
1041	Nelson Syndrome	0.8%
1042	Prolactinoma	0.7%
1043	Growth Hormone-Secreting Pituitary Adenoma	0.7%

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