MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Familial Mediterranean Fever

(UMLS:C0031069)

Definition:: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease.
UMLS ID:: C0031069
MeSH ID:: D010505

Classification:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.382.625

Synonym(s)

Familial Mediterranean Fever

ARMENIAN DISEASE

Benign paroxysmal peritonitis

FAMILIAL MEDITERRANEAN FEVER

FMF

FMF - Familial Mediterranean fever

FMF autosomal recessive

Familial Mediterranean fever

Familial mediterranean fever

10.

Familial paroxysmal polyserositis

11.

Familial recurrent polyserositis

12.

MEF - Familial Mediterranean fever

13.

PERIODIC POLYSEROSITIS

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Colchicine	FAERS: 7	View details 1499522 1575022 9848464 12910572 14632592 16889161 17505274 20661070	CTD US FAERS
2	Betamethasone	FAERS: 2		US FAERS
3	Cyclosporine	FAERS: 2		US FAERS
4	Terbinafine	FAERS: 2		OFFSIDES US FAERS
5	Tacrolimus	FAERS: 1		US FAERS
6	Terbinafine	FAERS: 1		US FAERS
7	Teriparatide	FAERS: 1		US FAERS
8	Azathioprine		14632592	CTD
9	Bosentan			OFFSIDES
10	Caspofungin			OFFSIDES
11	Caspofungin			OFFSIDES
12	Clorazepate Dipotassium			OFFSIDES
13	Clozapine			OFFSIDES
14	Diane			OFFSIDES
15	Epoprostenol			OFFSIDES
16	Imatinib Mesylate			OFFSIDES
17	Indomethacin			OFFSIDES
18	Medigoxin			OFFSIDES
19	Mercaptopurine			OFFSIDES
20	Methotrexate		17675778	CTD
21	Nitrendipine			OFFSIDES
22	Norgestrel			OFFSIDES
23	Ribavirin			OFFSIDES
24	azelastine		15805719	CTD
25	betamethasone butyrate propionate			OFFSIDES
26	fludarabine phosphate			OFFSIDES
27	sibutramine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Neoplastic Syndromes, Hereditary	22%
2	Multiple Epiphyseal Dysplasia	20.5%
3	Osteochondrodysplasias	20.5%
4	Pelger-Huet Anomaly	20.5%
5	Werner Syndrome	20.5%
6	Myasthenic Syndromes, Congenital	20.5%
7	CHARGE Syndrome	18.6%
8	Deformity	18.5%
9	Cystic Fibrosis	16.9%
10	Beckwith-Wiedemann Syndrome	16.7%
11	Wolf-Hirschhorn Syndrome	16.7%
12	Fragile X Syndrome	16.2%
13	Dwarfism	16.1%
14	Aicardi's syndrome	15.9%
15	Anemia, Sickle Cell	15.8%
16	Thalassemia	15.8%
17	Muscular Dystrophy, Duchenne	15.7%
18	Muscular Dystrophy	15.1%
19	Osteogenesis Imperfecta	15.1%
20	Nail-Patella Syndrome	15.1%
21	Rett Syndrome	14.6%
22	Albinism	13.7%
23	Smith-Magenis syndrome	13.5%
24	Amino Acid Metabolism, Inborn Errors	13.3%
25	Carbohydrate Metabolism, Inborn Errors	13.3%
26	Metal Metabolism, Inborn Errors	13.3%
27	Progeria	13.3%
28	Lysosomal Storage Diseases	13.3%
29	Cytochrome-c Oxidase Deficiency	13.3%
30	Peroxisomal Disorders	13.3%
31	Behcet Syndrome	13.3%
32	Cockayne Syndrome	13.3%
33	Cri-du-Chat Syndrome	13.2%
34	Down Syndrome	13.2%
35	Trisomy 21	13.2%
36	Ichthyosis, X-Linked	13.1%
37	Autoimmune Lymphoproliferative Syndrome	12.3%
38	Fetal Diseases	12.2%
39	Angioedemas, Hereditary	11.9%
40	Mucopolysaccharidosis II	11.8%
41	Alstrom Syndrome	11.7%
42	Sickle Cell Trait	11.6%
43	Wiskott-Aldrich Syndrome	11.3%
44	Ectodermal Dysplasia	11.1%
45	Aplasia Cutis Congenita	11.1%
46	Prader-Willi Syndrome	11%
47	Primary Ciliary Dyskinesia	10.8%
48	Holoprosencephaly	10.7%
49	Neuronal Ceroid-Lipofuscinoses	10.6%
50	Menkes Kinky Hair Syndrome	10.6%
51	Marfan Syndrome	10.5%
52	Polycystic Kidney Diseases	10.5%
53	Williams Syndrome	10.5%
54	Abdominal Cramps	10.3%
55	Abnormalities, Drug-Induced	10.3%
56	Amniotic Band Syndrome	10.3%
57	Asphyxia Neonatorum	10.3%
58	Infant, Premature, Diseases	10.3%
59	Situs Inversus	10.3%
60	Infantile Colic	10.3%
61	Smith-Lemli-Opitz Syndrome	10.2%
62	Cutis Laxa	10.2%
63	Retinitis Pigmentosa	10.1%
64	Pigmentary retinopathy	10.1%
65	Kartagener Syndrome	10%
66	Porokeratosis	10%
67	Keratoderma, Palmoplantar	10%
68	Chronic granulomatous disease	9.9%
69	Myotonic Dystrophy	9.9%
70	Welander Distal Myopathy	9.8%
71	Alkaptonuria	9.8%
72	Glycogen Storage Disease	9.8%
73	Hypophosphatasia	9.8%
74	Propionic acidemia	9.8%
75	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
76	Cystinosis	9.8%
77	Kallmann Syndrome	9.6%
78	Rubinstein-Taybi Syndrome	9.5%
79	Retinal Dysplasia	9.2%
80	Aniridia	9.1%
81	Tuberous Sclerosis	9%
82	Epidermolysis Bullosa	8.9%
83	Sjogren-Larsson Syndrome	8.6%
84	Acute Chest Syndrome	8.5%
85	Amyloid Neuropathies, Familial	8.5%
86	Galactosemias	8.3%
87	Urea Cycle Disorders, Inborn	8.3%
88	Tyrosinemias	8.3%
89	Adrenoleukodystrophy	8.2%
90	Duane Retraction Syndrome	8.2%
91	Hepatolenticular Degeneration	8.2%
92	Porphyrias, Hepatic	8.1%
93	Refsum Disease	8.1%
94	Glycogen Storage Disease Type I	8.1%
95	Glycogen Storage Disease Type V	8.1%
96	Mucopolysaccharidosis III	8%
97	Glycogen storage disease type II	8%
98	Peutz-Jeghers Syndrome	8%
99	Myotonia Congenita	7.9%
100	Thrombasthenia	7.9%
101	Antithrombin III Deficiency	7.9%
102	Protein C Deficiency	7.9%
103	Brain Diseases, Metabolic, Inborn	7.9%
104	Fabry Disease	7.9%
105	Afibrinogenemia	7.9%
106	Dystonia Musculorum Deformans	7.9%
107	Factor VII Deficiency	7.9%
108	Factor X Deficiency	7.9%
109	Factor XII Deficiency	7.9%
110	Hemophilia A	7.9%
111	Activated Protein C Resistance	7.9%
112	Factor II deficiency	7.9%
113	Factor VIII Deficiency	7.9%
114	Factor V deficiency	7.9%
115	Factor XI Deficiency	7.9%
116	Hypoprothrombinemias	7.9%
117	Fanconi Anemia	7.8%
118	Lafora Disease	7.8%
119	Unverricht-Lundborg Syndrome	7.8%
120	Anemia, Diamond-Blackfan	7.8%
121	Polycystic Kidney, Autosomal Dominant	7.7%
122	Ataxia Telangiectasia	7.6%
123	Classical Lissencephalies and Subcortical Band Heterotopias	7.4%
124	Optic Atrophy, Hereditary, Leber	7.3%
125	Eye Abnormalities	7.3%
126	Hypolipoproteinemias	7.3%
127	Papillon-Lefevre Disease	7.3%
128	Cardiovascular Abnormalities	7.3%
129	Hyperlipidemia, Familial Combined	7.3%
130	Hyperlipoproteinemia Type III	7.3%
131	Hyperphosphaturia	7.3%
132	Canavan Disease	7%
133	Alexander Disease	7%
134	Skin Abnormalities	7%
135	Lymphatic Abnormalities	7%
136	Congenital Microtia	7%
137	Meconium Aspiration Syndrome	6.9%
138	Multiple Endocrine Neoplasia	6.9%
139	Anemia, Neonatal	6.8%
140	Persistent Fetal Circulation Syndrome	6.8%
141	Xeroderma	6.8%
142	Mobius Syndrome	6.8%
143	Congenital diaphragmatic hernia	6.7%
144	Homocystinuria	6.7%
145	Congenital Hypothyroidism	6.7%
146	Umbilical hernia	6.7%
147	Pseudoxanthoma Elasticum	6.7%
148	Dermatitis, Atopic	6.7%
149	Leigh Disease	6.7%
150	Prune Belly Syndrome	6.7%
151	Twins, Conjoined	6.7%
152	Hyperkeratosis, Epidermolytic	6.7%
153	Waardenburg Syndrome	6.7%
154	Zellweger Syndrome	6.6%
155	Charcot-Marie-Tooth Disease	6.5%
156	Antley-Bixler Syndrome Phenotype	6.5%
157	Gaucher Disease	6.4%
158	Hypoalphalipoproteinemias	6%
159	Carbamoyl-Phosphate Synthase I Deficiency Disease	6%
160	Familial Periodic Paralysis	6%
161	Xeroderma Pigmentosum	6%
162	Lactose Intolerance	5.9%
163	Variegate Porphyria	5.9%
164	Acute intermittent porphyria	5.9%
165	Porphyria Cutanea Tarda	5.9%
166	Hyperhomocysteinemia	5.9%
167	Tay-Sachs Disease	5.8%
168	Renal Aminoacidurias	5.8%
169	Fanconi Syndrome	5.8%
170	Pseudohypoaldosteronism	5.8%
171	Liddle Syndrome	5.8%
172	Hyperlipoproteinemia Type IV	5.8%
173	Hyperlipoproteinemia Type V	5.8%
174	Anencephaly	5.8%
175	Niemann-Pick Disease, Type C	5.5%
176	Urogenital Abnormalities	5.5%
177	Neonatal Abstinence Syndrome	5.3%
178	Basal Cell Nevus Syndrome	5.3%
179	Fetal Growth Retardation	5.1%
180	Fetal Hypoxia	5%
181	Congenital nystagmus	5%
182	Fetal Alcohol Spectrum Disorders	5%
183	Klinefelter Syndrome	5%
184	Gout	5%
185	Toxoplasmosis, Congenital	5%
186	Syphilis, Congenital	5%
187	Multiple Endocrine Neoplasia Type 1	4.9%
188	Pseudohypoparathyroidism	4.9%
189	Huntington Disease	4.9%
190	Friedreich Ataxia	4.9%
191	Hypokalemic periodic paralysis	4.9%
192	Renal tubular acidosis	4.9%
193	Cystinuria	4.8%
194	Hydrops Fetalis	4.8%
195	Maxillofacial Abnormalities	4.7%
196	Dural Arteriovenous Fistula	4.7%
197	Dextrocardia	4.6%
198	Anophthalmos	4.5%
199	Anus, Imperforate	4.5%
200	Hydranencephaly	4.5%
201	Microphthalmos	4.5%
202	Neural Tube Defects	4.5%
203	Paralysis, Obstetric	4.5%
204	Retinopathy of Prematurity	4.5%
205	Tethered Cord Syndrome	4.5%
206	Iniencephaly	4.5%
207	Craniorachischisis	4.5%
208	Limb Deformities, Congenital	4.5%
209	Exencephaly	4.5%
210	Septo-Optic Dysplasia	4.5%
211	Craniofacial Abnormalities	4.5%
212	Cortical Dysplasia	4.5%
213	Malformations of Cortical Development	4.5%
214	Anorectal Malformations	4.5%
215	Bloom Syndrome	4.4%
216	Bronchopulmonary Dysplasia	4.4%
217	Nephroblastoma	4.4%
218	Turner Syndrome	4.1%
219	Arthritis, Gouty	4.1%
220	Congenital Hyperinsulinism	4.1%
221	Chorioamnionitis	4%
222	Adenomatous Polyposis Coli	3.9%
223	Familial Hypophosphatemic Rickets	3.7%
224	Glycosuria, Renal	3.6%
225	Microcephaly	3.6%
226	Macrocephaly	3.6%
227	Blepharophimosis	3.4%
228	Laryngostenosis	3.4%
229	Mouth Abnormalities	3.4%
230	Respiratory Distress Syndrome, Newborn	3.4%
231	Scimitar Syndrome	3.4%
232	Esophageal Atresia	3.4%
233	Intestinal Atresia	3.4%
234	Horseshoe Kidney	3.4%
235	Pectus excavatum	3.4%
236	Klippel-Feil Syndrome	3.4%
237	Gastroschisis	3.4%
238	Synostosis	3.4%
239	Acrodermatitis	3.3%
240	Lymphangiectasis, Intestinal	3.3%
241	Gianotti-Crosti Syndrome	3.3%
242	Abnormalities, Radiation-Induced	3.3%
243	Amelia	3.3%
244	Arachnodactyly	3.3%
245	Ectopia Cordis	3.3%
246	Ectromelia	3.3%
247	Hemimelia	3.3%
248	Meningomyelocele	3.3%
249	Phocomelia	3.3%
250	Sirenomelia	3.3%
251	Spina Bifida	3.3%
252	Polydactyly	3.3%
253	Brachydactyly	3.3%
254	Plagiocephaly	3.3%
255	Lower Extremity Deformities, Congenital	3.3%
256	Upper Extremity Deformities, Congenital	3.3%
257	Single umbilical artery	3.3%
258	Craniosynostosis	3.3%
259	Syndactyly	3.3%
260	Brachycephaly	3.3%
261	Porencephaly	3.2%
262	Acrocephalosyndactylia	2.9%
263	MELAS Syndrome	2.9%
264	Noonan Syndrome	2.9%
265	Denys-Drash Syndrome	2.8%
266	Ophthalmia Neonatorum	2.8%
267	Arthrogryposis	2.8%
268	Choanal Atresia	2.8%
269	Tracheobronchomegaly	2.8%
270	Laryngocele	2.8%
271	Choledochal Cyst	2.7%
272	Hermaphroditism	2.7%
273	Disorders of Sex Development	2.7%
274	Cryptorchidism	2.7%
275	Dermal Sinus	2.7%
276	Spina Bifida Cystica	2.7%
277	Spina Bifida Occulta	2.7%
278	Lissencephaly	2.7%
279	Polymicrogyria	2.7%
280	Pachygyria	2.7%
281	Schizencephaly	2.7%
282	Hypospadias	2.7%
283	Periventricular Nodular Heterotopia	2.7%
284	Central Nervous System Cysts	2.7%
285	Poland Syndrome	2.7%
286	Dandy-Walker Syndrome	2.7%
287	Leukomalacia, Periventricular	2.6%
288	POEMS Syndrome	2.6%
289	Jaw Abnormalities	2.6%
290	Nesidioblastosis	2.6%
291	Cleft Palate	2.5%
292	Aortic coarctation	2.5%
293	Cor Triatriatum	2.5%
294	Coronary Vessel Anomalies	2.5%
295	Dental Enamel Hypoplasia	2.5%
296	Patent ductus arteriosus	2.5%
297	Ebstein Anomaly	2.5%
298	Heart Septal Defects	2.5%
299	Hyaline Membrane Disease	2.5%
300	Hypodontia	2.5%
301	Macrostomia	2.5%
302	Meningocele	2.5%
303	Microstomia	2.5%
304	Tetralogy of Fallot	2.5%
305	Transposition of Great Vessels	2.5%
306	Hypoplastic Left Heart Syndrome	2.5%
307	May-Thurner Syndrome	2.5%
308	Encephalocele	2.5%
309	Craniofacial Dysostosis	2.5%
310	Wolff-Parkinson-White Syndrome	2.4%
311	Laryngomalacia	2.3%
312	Pectus carinatum	2.3%
313	Bladder Exstrophy	2.2%
314	Epispadias	2.2%
315	Multicystic Dysplastic Kidney	2.2%
316	Micrognathism	2.2%
317	Pierre Robin Syndrome	2.2%
318	Aortopulmonary Septal Defect	2%
319	Double Outlet Right Ventricle	2%
320	Endocardial Cushion Defects	2%
321	Myocardial bridging	2%
322	Aorticopulmonary Septal Defect	2%
323	Long QT Syndrome	2%
324	Platybasia	2%
325	Tricuspid Atresia	2%
326	Arrhythmogenic Right Ventricular Dysplasia	2%
327	Gonadal Dysgenesis	2%
328	Bronchomalacia	2%
329	Adrenogenital Syndrome	2%
330	Tracheomalacia	2%
331	Ovotesticular Disorders of Sex Development	2%
332	Retrognathia	1.9%
333	Kernicterus	1.9%
334	Truncus Arteriosus, Persistent	1.8%
335	Goldenhar Syndrome	1.8%
336	Hyperandrogenism	1.8%
337	Prognathism	1.7%
338	Mandibulofacial Dysostosis	1.6%
339	Romano-Ward Syndrome	1.6%
340	Talipes	1.5%
341	Congenital clubfoot	1.4%
342	Vertical Talus	1.4%
343	Arteriovenous fistula	1.2%

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