MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Multiple System Atrophy

(UMLS:C0393571)

Definition:: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
UMLS ID:: C0393571
MeSH ID:: D019578

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.177.575.550|C10.228.140.079.612|C10.228.662.550|C10.574.625

Synonym(s)

Multiple System Atrophy

MSA - Multiple system atrophy

Multiple system atrophy

Shy-Drager Syndrome

atrophy multiple system

atrophy multiple systems

multiple system atrophy

multisystem atrophy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Droxidopa	FAERS: 11		US FAERS
2	carbidopa, levodopa drug combination	FAERS: 6		US FAERS
3	Atorvastatin	FAERS: 3		US FAERS
4	Clozapine	FAERS: 3 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
5	Ruxolitinib phosphate	FAERS: 3		US FAERS
6	Lithium	FAERS: 2		US FAERS
7	Rivastigmine	FAERS: 2		US FAERS
8	Valproic Acid	FAERS: 2		US FAERS
9	Varenicline	FAERS: 2		US FAERS
10	Zoledronic Acid	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
11	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
12	Carbamazepine	FAERS: 1		US FAERS
13	Carbidopa, levodopa, and entacapone	FAERS: 1		US FAERS
14	Carnitine	FAERS: 1		US FAERS
15	Diphenhydramine	FAERS: 1		US FAERS
16	Insulin Glargine	FAERS: 1		US FAERS
17	Lurasidone Hydrochloride	FAERS: 1		US FAERS
18	Methotrexate	FAERS: 1		US FAERS
19	Metoclopramide	FAERS: 1		US FAERS
20	Rivaroxaban	FAERS: 1		US FAERS
21	Terazosin	FAERS: 1		US FAERS
22	Vincristine	FAERS: 1		US FAERS
23	fesoterodine	FAERS: 1		US FAERS
24	Bisacodyl			OFFSIDES
25	Chlorthalidone			OFFSIDES
26	Glyburide			OFFSIDES
27	Levodopa		1469394 9087971	CTD
28	Moxisylyte		10699651	CTD
29	Pirenzepine			OFFSIDES
30	Prazosin		10699651	CTD
31	Probenecid			OFFSIDES
32	Quinidine			OFFSIDES
33	Selegiline			OFFSIDES
34	Sirolimus			OFFSIDES
35	alfacalcidol			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Parkinson Disease	53.9%
2	Lewy Body Disease	53.2%
3	Parkinsonian Disorders	52.2%
4	Meningoencephalitis	48.1%
5	Dystonia Musculorum Deformans	46.1%
6	Meige Syndrome	45.3%
7	Progressive supranuclear palsy	44.7%
8	Encephalomyelitis	44.1%
9	Huntington Disease	40.9%
10	Prion Diseases	40.7%
11	Amyotrophic Lateral Sclerosis	39.3%
12	Pneumocephalus	37.9%
13	Motor Neuron Disease	37.7%
14	Basal Ganglia Cerebrovascular Disease	37%
15	Spinal Muscular Atrophy	36.8%
16	Progressive Muscular Atrophy	36.8%
17	Subdural Effusion	36.7%
18	Dandy-Walker Syndrome	36.4%
19	Subacute Combined Degeneration	36.3%
20	Ocular Motility Disorders	36.2%
21	Cyclophoria	36.2%
22	MPTP Poisoning	35.8%
23	Epidural Abscess	35.3%
24	Asterixis	34.8%
25	Ballismus	34.8%
26	Myelitis	34.6%
27	Neuroleptic Malignant Syndrome	34.6%
28	Stiff-Person Syndrome	34.5%
29	Dementia, Vascular	34.1%
30	Hepatolenticular Degeneration	32.6%
31	Meningitis	32%
32	Pachymeningitis	32%
33	Spinal Cord Diseases	32%
34	Essential Tremor	31.5%
35	Familial Tremor	31.5%
36	Writer's Cramp	31.5%
37	Marchiafava-Bignami Disease	31.5%
38	Brain Abscess	31.1%
39	Epilepsy, Post-Traumatic	30.9%
40	Posterior Leukoencephalopathy Syndrome	30.9%
41	Posterior reversible encephalopathy syndrome	30.9%
42	Limbic Encephalitis	30.5%
43	Autonomic Dysreflexia	30.5%
44	Complex Regional Pain Syndromes	30.5%
45	Myelitis, Transverse	30%
46	Leukoencephalopathy, Progressive Multifocal	29.8%
47	Cerebral Ventriculitis	29.8%
48	Ophthalmoplegic Migraine	29.7%
49	Poliomyelitis	29.6%
50	Leukoencephalitis, Acute Hemorrhagic	29.2%
51	Akinetic Mutism	28.9%
52	Anoxic Encephalopathy	28.9%
53	Brain Damage, Chronic	28.9%
54	Cerebellar Diseases	28.9%
55	Encephalitis	28.9%
56	Encephalomalacia	28.9%
57	Epilepsy	28.9%
58	Hydrocephalus	28.9%
59	Congenital Hydrocephalus	28.9%
60	Hypothalamic Diseases	28.9%
61	Thalamic Diseases	28.9%
62	Intracranial Hypertension	28.9%
63	Aura	28.9%
64	Leukoencephalopathy	28.9%
65	Neuroaxonal Dystrophies	28.9%
66	Headache Disorders	28.9%
67	Intracranial Hypotension	28.9%
68	Brain Edema	28.9%
69	Brain Hypoxia	28.9%
70	Aqueductal Stenosis	28.9%
71	Lafora Disease	28.8%
72	Unverricht-Lundborg Syndrome	28.8%
73	Lupus Vasculitis, Central Nervous System	28.8%
74	Brain Injuries	28.7%
75	Cranial nerve diseases	28.7%
76	Demyelinating Diseases	28.7%
77	Demyelination	28.7%
78	Neuromuscular Diseases	28.7%
79	Chronobiology Disorders	28.7%
80	Brain Neoplasms	28.6%
81	Presenile dementia	28.6%
82	Senile dementia	28.6%
83	Tauopathies	27.9%
84	Spinal Cord Injuries	27.9%
85	Multiple System Atrophy	27.7%
86	Central Nervous System Infection	27.5%
87	Myoclonic Epilepsy	27.5%
88	Epilepsy, Temporal Lobe	27.5%
89	Epilepsy, Rolandic	27.5%
90	Benign Rolandic Epilepsy	27.5%
91	Cerebellar Neoplasms	27.4%
92	Opsoclonus-Myoclonus Syndrome	27.4%
93	Basal Ganglia Hemorrhage	27.3%
94	Akathisia, Drug-Induced	27%
95	Myelinolysis, Central Pontine	26.9%
96	Restless Legs Syndrome	26.8%
97	Polyradiculoneuropathy	26.7%
98	Polyradiculoneuritis	26.7%
99	Miller Fisher Syndrome	26.6%
100	Vascular Headaches	26.5%
101	Hypoxia-Ischemia, Brain	26.4%
102	Friedreich Ataxia	26%
103	Dyskinesia, Drug-Induced	25.9%
104	Leukomalacia, Periventricular	25.7%
105	Meningitis, Bacterial	25.7%
106	Meningitis, Fungal	25.7%
107	Progressive bulbar palsy	25.7%
108	Bulbar palsy	25.7%
109	Creutzfeldt-Jakob disease	25.6%
110	Canavan Disease	25.4%
111	Alexander Disease	25.4%
112	Brain Death	25.1%
113	Scrapie	25%
114	Paraneoplastic Cerebellar Degeneration	24.9%
115	Chorea	24.6%
116	Trauma, Nervous System	24.6%
117	Chronic Fatigue Syndrome	24.5%
118	Encephalomyelitis, Acute Disseminated	24.4%
119	Brain Diseases, Metabolic	24.3%
120	Cerebrovascular Disorders	24.3%
121	Cerebrovascular Insufficiency	24.3%
122	Dementia	24.3%
123	Causalgia	24.2%
124	Juvenile Myoclonic Epilepsy	24.1%
125	Myoclonic Epilepsies, Progressive	24.1%
126	Putaminal Hemorrhage	24.1%
127	Nervous System Neoplasms	24%
128	Neurologic Manifestations	24%
129	Neurotoxicity Syndromes	24%
130	Lambert-Eaton Myasthenic Syndrome	23.8%
131	Brain Hemorrhage, Traumatic	23.4%
132	Amblyopia	23.4%
133	Orthostatic intolerance	22.9%
134	Spinal Cord Neoplasms	22.9%
135	Guillain-Barre Syndrome	22.8%
136	Torticollis	22.6%
137	Pituitary Adenoma	22.6%
138	Pituitary Neoplasms	22.6%
139	Tuberculosis, Meningeal	22.1%
140	Carotid Artery Injuries	22%
141	Toxoplasmosis, Cerebral	21.8%
142	Brain Diseases	21.8%
143	Reflex Sympathetic Dystrophy	21.1%
144	Vasculitis, Central Nervous System	20.9%
145	Horner Syndrome	20.9%
146	Sleep Wake Disorders	20.8%
147	Arachnoiditis	20.8%
148	Aseptic Meningitis	20.8%
149	Syringomyelia	20.8%
150	Pneumorrhachis	20.8%
151	Sweating, Gustatory	20.8%
152	Auriculotemporal Syndrome	20.8%
153	Brain Injuries, Diffuse	20.8%
154	Traumatic Brain Injury	20.8%
155	Pituitary Apoplexy	20.7%
156	Cerebellar Ataxia	20.7%
157	Supratentorial Neoplasms	20.7%
158	Cerebral Palsy	20.7%
159	Epilepsies, Partial	20.7%
160	Epilepsy, Generalized	20.7%
161	Pseudotumor Cerebri	20.7%
162	Hypertensive Encephalopathy	20.7%
163	Simple Partial Seizures	20.7%
164	Epilepsy, Reflex	20.7%
165	Postural Orthostatic Tachycardia Syndrome	20.7%
166	Headache Disorders, Primary	20.7%
167	Headache Disorders, Secondary	20.7%
168	Medication overuse headache	20.7%
169	Brain Infarction	20.5%
170	Peripheral Nerve Injuries	20.5%
171	Striatonigral Degeneration	20.4%
172	Infarction, Middle Cerebral Artery	20.4%
173	Infarction, Anterior Cerebral Artery	20.4%
174	Infarction, Posterior Cerebral Artery	20.4%
175	Myasthenia Gravis	20.3%
176	Neuromyelitis Optica	20%
177	Paraneoplastic Encephalomyelitis	20%
178	Amnesia, Transient Global	19.8%
179	Movement Disorders	19.7%
180	Tardive Dyskinesia	19.7%
181	Persistent Vegetative State	19.7%
182	Frontotemporal dementia	19.7%
183	Olfactory Nerve Injuries	19.5%
184	Central Cord Syndrome	19.2%
185	Charcot-Marie-Tooth Disease	18.6%
186	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	18.6%
187	Sleep Disorders, Circadian Rhythm	18.2%
188	Shy-Drager Syndrome	18.2%
189	Subacute Sclerosing Panencephalitis	18.1%
190	Cerebral Infarction	17.9%
191	Brain Stem Infarctions	17.9%
192	Pituitary Diseases	17.8%
193	Botulism	17.6%
194	Central Nervous System Cysts	17.6%
195	Central Nervous System Fungal Infections	17.5%
196	Conus Medullaris Syndrome	17.5%
197	Spinal Cord Vascular Diseases	17.5%
198	Myotonia Congenita	17.5%
199	Tuberous Sclerosis	17.5%
200	Ataxia Telangiectasia	17.5%
201	Facial Nerve Injuries	17.3%
202	Meningitis, Cryptococcal	17.3%
203	Meningitis, Listeria	17.2%
204	Carotid Artery Diseases	17.2%
205	Brain Ischemia	17.2%
206	Hypotension, Orthostatic	17.2%
207	Cerebrovascular accident	17.2%
208	Kluver-Bucy Syndrome	17.2%
209	Vasospasm, Intracranial	17.2%
210	Intracranial Arterial Diseases	17.2%
211	Post-Exercise Hypotension	17.2%
212	Meningitis, Haemophilus	17.2%
213	Meningitis, Pneumococcal	17.2%
214	Moyamoya Disease	17.1%
215	Vagus Nerve Disorder	17%
216	Glossopharyngeal Neuralgia	17%
217	Abducens Nerve Diseases	17%
218	Heavy Metal Poisoning, Nervous System	17%
219	Neuromuscular Junction Diseases	17%
220	Trochlear Nerve Diseases	17%
221	Peripheral Nervous System Diseases	17%
222	Diffuse Axonal Injury	16.9%
223	Brain Stem Neoplasms	16.8%
224	Subarachnoid Hemorrhage, Traumatic	16.8%
225	Carotid Artery, Internal, Dissection	16.8%
226	Nocturnal Myoclonus Syndrome	16.7%
227	Lateral Medullary Syndrome	16.6%
228	Post-Traumatic Headache	16.6%
229	Tension Headache	16.6%
230	Epilepsy, Complex Partial	16.6%
231	Migraine Disorders	16.6%
232	Abdominal Migraine	16.6%
233	Status Migrainosus	16.6%
234	Cervicogenic Headache	16.6%
235	Refsum Disease	16.5%
236	Adrenoleukodystrophy	16.2%
237	Multiple Sclerosis	16.2%
238	Mitochondrial Encephalomyopathies	16.2%
239	Brain Concussion	16%
240	Myotonic Dystrophy	15.9%
241	Alice in Wonderland Syndrome	15.7%
242	Myasthenia Gravis, Autoimmune, Experimental	15.5%
243	Vertebral Artery Dissection	15.4%
244	MELAS Syndrome	15.2%
245	Central Nervous System Bacterial Infections	15.1%
246	Choroid Plexus Papilloma	14.9%
247	West Nile Fever	14.9%
248	Brain Contusion	14.8%
249	Basal Ganglia Diseases	14.8%
250	Reye Syndrome	14.8%
251	Intracranial Embolism and Thrombosis	14.7%
252	Hepatic Encephalopathy	14.7%
253	Myopathy	14.6%
254	Optic Neuropathy	14.6%
255	Cluster Headache	14.6%
256	Migraine with Aura	14.6%
257	Familial Hemiplegic Migraine	14.6%
258	Chronic Paroxysmal Hemicrania	14.6%
259	SUNCT Syndrome	14.6%
260	Paroxysmal Hemicrania	14.6%
261	Auditory Perceptual Disorders	14.5%
262	Brachial Plexus Neuritis	14.4%
263	Neuralgic Amyotrophy	14.4%
264	Facial Nerve Diseases	14.3%
265	Craniocerebral Trauma	14.3%
266	Ophthalmoplegia	14.3%
267	Parasomnia	14.3%
268	External Ophthalmoplegia	14.3%
269	Dyssomnias	14.3%
270	Acrodynia	14.2%
271	Jet Lag Syndrome	14.1%
272	Vestibulocochlear Nerve Diseases	14.1%
273	Decerebrate State	14.1%
274	Hemiparesis	14.1%
275	Hydranencephaly	14.1%
276	Meningism	14.1%
277	Neural Tube Defects	14.1%
278	Paresis	14.1%
279	Seizures	14.1%
280	Sensation Disorders	14.1%
281	Tethered Cord Syndrome	14.1%
282	Central Nervous System Neoplasms	14.1%
283	Complex partial seizures	14.1%
284	Iniencephaly	14.1%
285	Craniorachischisis	14.1%
286	Exencephaly	14.1%
287	Monoparesis	14.1%
288	Septo-Optic Dysplasia	14.1%
289	Cortical Dysplasia	14.1%
290	Neurogenic Inflammation	14.1%
291	Gait Disorders, Neurologic	14.1%
292	Neuromuscular Manifestations	14.1%
293	Malformations of Cortical Development	14.1%
294	Empty Sella Syndrome	14%
295	Hyperpituitarism	14%
296	Hypopituitarism	14%
297	Hypophysitis	14%
298	Cerebral Arterial Diseases	13.8%
299	Vertebrobasilar Insufficiency	13.8%
300	Basilar Artery Stenosis	13.8%
301	Vertebral Artery Stenosis	13.8%
302	Intracranial Hemorrhage, Hypertensive	13.8%
303	Transient Cerebral Ischemia	13.8%
304	Tarsal Tunnel Syndrome	13.2%
305	Cauda Equina Syndrome	13.2%
306	Dysautonomia	12.9%
307	Brain Diseases, Metabolic, Inborn	12.9%
308	Alstrom Syndrome	12.9%
309	Coma, Post-Head Injury	12.8%
310	Vocal Cord Paralysis	12.8%
311	Spinal Cord Ischemia	12.8%
312	Tuberculosis, Central Nervous System	12.7%
313	Giant Cell Arteritis	12.6%
314	Temporal Arteritis	12.6%
315	Amyloid Neuropathies, Familial	12.5%
316	Pupil Disorders	12.4%
317	Neurobehavioral Manifestations	12.4%
318	Cerebrospinal Fluid Otorrhea	12.4%
319	Cerebrospinal Fluid Rhinorrhea	12.4%
320	Neuritis, Autoimmune, Experimental	12.4%
321	Gait Ataxia	12.4%
322	Multiple Sclerosis, Chronic Progressive	12.2%
323	Multiple Sclerosis, Relapsing-Remitting	12.2%
324	Hyperprolactinemia	12.2%
325	Uveomeningoencephalitic Syndrome	12.1%
326	Subclavian Steal Syndrome	12.1%
327	Pick Disease of the Brain	12.1%
328	Sturge-Weber Syndrome	12%
329	Vertigo	12%
330	Alcohol-Induced Disorders, Nervous System	12%
331	Carotid Stenosis	11.8%
332	Intracranial Aneurysm	11.8%
333	Intracranial Arteriosclerosis	11.8%
334	Cerebral Atherosclerosis	11.8%
335	Subarachnoid Hemorrhage	11.8%
336	Cerebral Arteriosclerosis	11.8%
337	Cerebral Hemorrhage	11.8%
338	Cerebral Thrombosis	11.7%
339	Intracranial Embolism	11.7%
340	Intracranial Thrombosis	11.7%
341	Optic Nerve Glioma	11.6%
342	Hematoma, Subdural	11.4%
343	Hematoma, Epidural, Cranial	11.4%
344	Neuritis	11.4%
345	Polyneuritis	11.4%
346	Radiculitis	11.4%
347	Polyneuropathy	11.4%
348	Mononeuritis	11.4%
349	Mononeuropathies	11.4%
350	Brachial Plexus Neuropathies	11.4%
351	Radiculopathy	11.4%
352	Mononeuropathy Multiplex	11.4%
353	Nerve Root Compression	11.4%
354	Wernicke Encephalopathy	11.4%
355	AIDS Dementia Complex	11.4%
356	Carpal Tunnel Syndrome	11.3%
357	neurofibroma	11.3%
358	Sciatica	11.3%
359	Alcohol Withdrawal Seizures	11.2%
360	Akathisia	11%
361	Restlessness	11%
362	Psychomotor Agitation	11%
363	Neuroaspergillosis	11%
364	Voice Disorders	10.7%
365	Voice Disturbance	10.7%
366	Neuronal Ceroid-Lipofuscinoses	10.6%
367	Smith-Magenis syndrome	10.5%
368	Dural Arteriovenous Fistula	10.5%
369	Anterior Spinal Artery Syndrome	10.5%
370	Acromegaly	10.4%
371	Kernicterus	10.4%
372	Cubital Tunnel Syndrome	10.3%
373	Cerebral Amyloid Angiopathy	10.3%
374	Sinus Thrombosis, Intracranial	10.3%
375	Carotid Artery Thrombosis	10.2%
376	Gait Apraxia	10.2%
377	Hematoma, Subdural, Intracranial	10.2%
378	Hematoma, Subdural, Chronic	10.2%
379	Hematoma, Subdural, Acute	10.2%
380	Optic Atrophy, Hereditary, Leber	10.2%
381	Pseudorabies	9.9%
382	Cockayne Syndrome	9.7%
383	Myositis	9.6%
384	Optic Atrophy	9.6%
385	Optic Neuritis	9.6%
386	Papilledema	9.6%
387	Strabismus	9.6%
388	Tolosa-Hunt Syndrome	9.6%
389	Isaacs syndrome	9.6%
390	Arsenic Poisoning	9.6%
391	Myotonic Disorders	9.6%
392	Myasthenic Syndromes, Congenital	9.6%
393	Cavernous Sinus Thrombosis	9.6%
394	Sagittal Sinus Thrombosis	9.6%
395	Diabetic Neuropathies	9.5%
396	Facial Injuries	9.5%
397	Facial Neuralgia	9.5%
398	Diabetic Amyotrophy	9.5%
399	Diabetic Autonomic Neuropathy	9.5%
400	Sleep Talking	9.5%
401	Manganese Poisoning	9.5%
402	Sleep Disorders, Intrinsic	9.5%
403	Neurosyphilis	9.5%
404	Anosmia	9.4%
405	Ataxia	9.4%
406	Athetosis	9.4%
407	Catalepsy	9.4%
408	Dystonia	9.4%
409	Hemiplegia	9.4%
410	Locked-In Syndrome	9.4%
411	Meningeal Neoplasms	9.4%
412	Meningomyelocele	9.4%
413	Muscle Hypertonia	9.4%
414	Muscle hypotonia	9.4%
415	Myoclonus	9.4%
416	Myotonia	9.4%
417	Neuralgia	9.4%
418	Paraplegia	9.4%
419	Pseudobulbar Palsy	9.4%
420	Quadriplegia	9.4%
421	Spasm	9.4%
422	Spastic Paraplegia	9.4%
423	Status Epilepticus	9.4%
424	Taste Disorders	9.4%
425	Tremor	9.4%
426	Spina Bifida	9.4%
427	Monoplegia	9.4%
428	Hypokinesia	9.4%
429	Paraparesis	9.4%
430	Bradykinesia	9.4%
431	Waxy flexibility	9.4%
432	Action Tremor	9.4%
433	Resting Tremor	9.4%
434	Dysosmia	9.4%
435	Quadriparesis	9.4%
436	Mercury Poisoning, Nervous System	9.4%
437	Olfaction Disorders	9.4%
438	Myokymia	9.4%
439	Lead Poisoning, Nervous System	9.4%
440	Vestibular Neuronitis	9.4%
441	Somatosensory Disorders	9.4%
442	Neuropathic pain	9.4%
443	Hyperkinesia	9.4%
444	Intention tremor	9.4%
445	Reflex, Abnormal	9.3%
446	Hyporeflexia	9.3%
447	Hyperreflexia	9.3%
448	Fabry Disease	9.2%
449	Toxoplasmosis, Congenital	9.1%
450	Waterhouse-Friderichsen Syndrome	9%
451	Malaria, Cerebral	9%
452	Neurocysticercosis	9%
453	Classical Lissencephalies and Subcortical Band Heterotopias	8.7%
454	Sciatic Neuropathy	8.7%
455	Ulnar Neuropathies	8.7%
456	Lesion of Sciatic Nerve	8.7%
457	Ulnar Neuritis	8.7%
458	Radial nerve compression	8.7%
459	Radial Tunnel Syndrome	8.7%
460	Peroneal Neuropathies	8.7%
461	Radial Neuropathy	8.7%
462	Median Neuropathy	8.7%
463	Sciatic Nerve Palsy	8.7%
464	Femoral Neuropathy	8.7%
465	Tibial Neuropathy	8.7%
466	Ulnar Nerve Palsy	8.7%
467	Radial nerve palsy	8.7%
468	Acoustic Neuroma	8.6%
469	Hand-Arm Vibration Syndrome	8.5%
470	Menkes Kinky Hair Syndrome	8.4%
471	Nelson Syndrome	8.4%
472	Lyme Neuroborreliosis	8.4%
473	Vision Disorders	8.3%
474	Metamorphopsia	8.3%
475	Visual Impairment	8.3%
476	Fibromyalgia	8.3%
477	Optic Neuropathy, Ischemic	8.3%
478	Anterior Ischemic Optic Neuropathy	8.3%
479	Medial Tibial Stress Syndrome	8.3%
480	Facial Hemiatrophy	8.2%
481	Melkersson-Rosenthal Syndrome	8.2%
482	Mitochondrial Myopathies	8.2%
483	Galactosemias	8.2%
484	Urea Cycle Disorders, Inborn	8.2%
485	Tyrosinemias	8.2%
486	Anisocoria	8.2%
487	Confusion	8.2%
488	Facial paralysis	8.2%
489	Lethargy	8.2%
490	Memory Disorders	8.2%
491	Muscle Cramp	8.2%
492	Perceptual Disorders	8.2%
493	Psychomotor Disorders	8.2%
494	Tonic Pupil	8.2%
495	Eosinophilia-Myalgia Syndrome	8.2%
496	Anhedonia	8.2%
497	Disorientation	8.2%
498	Facial Paresis	8.2%
499	Memory Loss	8.2%
500	Hemisensory Neglect	8.2%
501	Dysacusis	8.2%
502	Sleep Bruxism	8.1%
503	Anencephaly	8.1%
504	Meningocele	8.1%
505	Muscular Atrophy	8.1%
506	Respiratory Paralysis	8.1%
507	Encephalocele	8.1%
508	Prolactinoma	8.1%
509	Growth Hormone-Secreting Pituitary Adenoma	8.1%
510	Tetany	8.1%
511	Alexia	8%
512	Dyslexia	8%
513	Kearns-Sayre syndrome	7.7%
514	Neurofibrosarcoma	7.6%
515	Homocystinuria	7.5%
516	Leigh Disease	7.4%
517	Polyradiculopathy	7.3%
518	Thoracic Outlet Syndrome	7.3%
519	Duane Retraction Syndrome	7.2%
520	Esotropia	7.2%
521	Exotropia	7.2%
522	Sleep Apnea Syndromes	7.2%
523	Polymyositis	7.2%
524	Consciousness Disorders	7.2%
525	Mental Retardation	7.2%
526	Muscle Weakness	7.2%
527	Depressed Level of Consciousness	7.2%
528	Mental deficiency	7.2%
529	Intellectual Disability	7.2%
530	Disorders of Excessive Somnolence	7.2%
531	Sleep Initiation and Maintenance Disorders	7.2%
532	Night Terrors	7.2%
533	Somnambulism	7.2%
534	Trigeminal Nerve Disorder	7.2%
535	Transient Insomnia	7.2%
536	Sleep Paralysis	7.2%
537	Chronic Insomnia	7.2%
538	REM Sleep Behavior Disorder	7.2%
539	Hypersomnia	7.2%
540	Mobius Syndrome	7.2%
541	Bell Palsy	7.2%
542	Dermal Sinus	7.2%
543	Dysgeusia	7.2%
544	Formication	7.2%
545	Hyperalgesia	7.2%
546	Hyperesthesia	7.2%
547	Hypesthesia	7.2%
548	Language Disorders	7.2%
549	Numbness	7.2%
550	Paresthesia	7.2%
551	Paraparesis, Spastic	7.2%
552	Spina Bifida Cystica	7.2%
553	Trismus	7.2%
554	Spina Bifida Occulta	7.2%
555	Epilepsia Partialis Continua	7.2%
556	Hypogeusia	7.2%
557	Meningeal Carcinomatosis	7.2%
558	Brown-Sequard Syndrome	7.2%
559	Lissencephaly	7.2%
560	Polymicrogyria	7.2%
561	Pachygyria	7.2%
562	Schizencephaly	7.2%
563	Lockjaw	7.2%
564	Allodynia	7.2%
565	Lead Poisoning, Nervous System, Childhood	7.2%
566	Lead Poisoning, Nervous System, Adult	7.2%
567	Periventricular Nodular Heterotopia	7.2%
568	Ageusia	7.2%
569	Catatonia	7.1%
570	Herpes Zoster Oticus	7.1%
571	Familial Periodic Paralysis	7.1%
572	Aphonia	7.1%
573	Sleep Deprivation	7.1%
574	Dysphonia	7.1%
575	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.5%
576	Eye Injuries	6.3%
577	Myalgia	6.3%
578	Muscular Dystrophy	6.2%
579	Congenital nystagmus	6.2%
580	Orbital Myositis	6.2%
581	Diplopia	6.2%
582	Muscle Rigidity	6.2%
583	Muscle Spasticity	6.2%
584	Scotoma	6.2%
585	Photophobia	6.2%
586	Cogwheel Rigidity	6.2%
587	Hemifacial Spasm	6.2%
588	Amaurosis	6.2%
589	Blindness	6.2%
590	Nuchal Rigidity	6.2%
591	Pyomyositis	6.2%
592	Agnosia	6.1%
593	Apraxias	6.1%
594	Hallucinations	6.1%
595	Hemianopsia	6.1%
596	Hyperacusis	6.1%
597	Tinnitus	6.1%
598	Visual Agnosia	6.1%
599	Anosognosia	6.1%
600	Wernicke-Korsakoff Syndrome	6.1%
601	Phonophobia	6.1%
602	Hearing Loss	6.1%
603	Sarcopenia	6.1%
604	Sleep Apnea, Obstructive	6.1%
605	Sleep Apnea, Central	6.1%
606	Narcolepsy	6%
607	Trigeminal Neuralgia	6%
608	Kleine-Levin Syndrome	6%
609	Agraphia	6%
610	Anomia	6%
611	Cluttering	6%
612	Language Development Disorders	6%
613	Speech Disorders	6%
614	Syncope	6%
615	Stupor	6%
616	Dysgraphia	6%
617	Presyncope	6%
618	Dyslalia	6%
619	Glycogen storage disease type II	5.9%
620	Zellweger Syndrome	5.9%
621	Aicardi's syndrome	5.7%
622	Hoarseness	5.7%
623	Alcohol Withdrawal Delirium	5.6%
624	Cataplexy	5.5%
625	Aphasia	5.5%
626	Articulation Disorders	5.5%
627	Echolalia	5.5%
628	Stuttering	5.5%
629	Dysphasia	5.5%
630	Amnesia	5.4%
631	Delirium	5.4%
632	Dissociative Amnesia	5.4%
633	Color blindness	5.4%
634	Global Amnesia	5.4%
635	Cri-du-Chat Syndrome	5.4%
636	Down Syndrome	5.4%
637	Trisomy 21	5.4%
638	POEMS Syndrome	5.4%
639	Meningioma	5.4%
640	Williams Syndrome	5.4%
641	Microcephaly	5.4%
642	Macrocephaly	5.4%
643	Hypokalemic periodic paralysis	5.3%
644	Porencephaly	5.3%
645	Eye Burns	5.2%
646	Welander Distal Myopathy	5.2%
647	Dysarthria	5.2%
648	Amaurosis Fugax	5.2%
649	Blindness, Cortical	5.2%
650	Dyscalculia	5.2%
651	Rett Syndrome	5.2%
652	Deafness	5.2%
653	Hearing Loss, Sudden	5.2%
654	Gerstmann Syndrome	5.2%
655	Hearing Loss, Bilateral	5.2%
656	Hearing Loss, High-Frequency	5.2%
657	Hearing Loss, Mixed Conductive-Sensorineural	5.2%
658	Prosopagnosia	5.2%
659	Apraxia, Ideomotor	5.2%
660	Charles Bonnet Syndrome	5.2%
661	Hearing Loss, Unilateral	5.2%
662	Complete Hearing Loss	5.2%
663	Alien Hand Syndrome	5.2%
664	Deaf Mutism	5.2%
665	Holoprosencephaly	5.1%
666	Gaucher Disease	5.1%
667	Prader-Willi Syndrome	4.8%
668	Tay-Sachs Disease	4.8%
669	Mutism	4.7%
670	Selective Mutism	4.7%
671	Phantom pain	4.7%
672	Phantom Limb Pain	4.7%
673	Dermatomyositis	4.6%
674	Corneal Scar	4.6%
675	Muscular Dystrophy, Duchenne	4.6%
676	Retrograde amnesia	4.5%
677	Amnesia, Anterograde	4.5%
678	Niemann-Pick Disease, Type C	4.5%
679	Alexia, Pure	4.5%
680	Corneal Perforation	4.1%
681	Fragile X Syndrome	4%
682	Rubinstein-Taybi Syndrome	3.9%
683	Mucopolysaccharidosis II	3%

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