MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Alkalosis

(UMLS:C0002063)

Definition:: A pathological condition that removes acid or adds base to the body fluids.
UMLS ID:: C0002063
MeSH ID:: D000471

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.076.354

Synonym(s)

Alkalosis

ALKALOSIS

Alkalosis, NOS

alkaloses

alkalosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	4-hydroxybutyric acid	FAERS: 4		US FAERS
2	Flecainide	FAERS: 4		US FAERS
3	Aspirin	FAERS: 3		US FAERS
4	6-Chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide;3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride	FAERS: 2		US FAERS
5	Clozapine	FAERS: 2		US FAERS
6	Furosemide	FAERS: 2	View details 635611 3572225 7182184 8184892 18259658	CTD US FAERS
7	Gentamicins	FAERS: 2	12571406	CTD US FAERS
8	Hydrochlorothiazide	FAERS: 2		US FAERS
9	Topiramate	FAERS: 2		US FAERS
10	Ursodeoxycholic Acid	FAERS: 2		US FAERS
11	posaconazole	FAERS: 2		US FAERS
12	temsirolimus	FAERS: 2		US FAERS
13	Daunorubicin	FAERS: 1		US FAERS
14	Enalapril	FAERS: 1		US FAERS
15	Enalapril	FAERS: 1		US FAERS
16	Etoposide	FAERS: 1		US FAERS
17	Glipizide	FAERS: 1		US FAERS
18	LCZ 696	FAERS: 1		US FAERS
19	Levetiracetam	FAERS: 1		US FAERS
20	Linezolid	FAERS: 1		US FAERS
21	Micafungin	FAERS: 1		US FAERS
22	Octreotide	FAERS: 1		US FAERS
23	Olanzapine	FAERS: 1		US FAERS
24	Paroxetine	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
25	Potassium Chloride	FAERS: 1		US FAERS
26	Risperidone	FAERS: 1		US FAERS
27	Rosuvastatin Calcium	FAERS: 1		US FAERS
28	Sevelamer	FAERS: 1		US FAERS
29	Testosterone	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
30	Varenicline	FAERS: 1		US FAERS
31	aliskiren	FAERS: 1		US FAERS
32	bosutinib	FAERS: 1		US FAERS
33	trandolapril	FAERS: 1		US FAERS
34	Acetazolamide		6410668 6816846	CTD
35	Amikacin		19884751	CTD
36	Amiloride		12185466	CTD
37	Ampicillin		326044	CTD OFFSIDES
38	Anastrozole			OFFSIDES
39	Atracurium			OFFSIDES
40	Beclomethasone			OFFSIDES
41	Bumetanide		9824779	CTD
42	Calcitriol		8667442	CTD
43	Calcium Carbonate		8481062 8667442	CTD
44	Calcium Compounds		8667442	CTD
45	Carbenicillin		7687	CTD
46	Chlorthalidone	Canada Vigilance: 2		Canada Vigilance OFFSIDES
47	Cocaine		16791405	CTD
48	Cyclophosphamide		582354	CTD
49	Cytarabine			OFFSIDES
50	Daunorubicin			OFFSIDES
51	Donepezil			OFFSIDES
52	Ethacrynic Acid	Canada Vigilance: 1		Canada Vigilance
53	Fludrocortisone		6622340	CTD
54	Hydralazine		635611	CTD
55	Hydrocortisone		8667442 15090754	CTD
56	Indomethacin			SIDER
57	Melphalan			OFFSIDES
58	Meprobamate			OFFSIDES
59	Methyldopa		635611	CTD
60	Methylene Blue			OFFSIDES
61	Methylprednisolone			SIDER
62	Metolazone		635611	CTD
63	Metronidazole			OFFSIDES
64	Mycophenolic Acid			SIDER
65	Nafcillin		7431181	CTD
66	Nandrolone Decanoate		15849280	CTD
67	Naproxen			SIDER
68	Nitrous Oxide			OFFSIDES
69	Nizatidine			OFFSIDES
70	Oxymetholone		15849280	CTD
71	Pamidronate		8667442	CTD OFFSIDES
72	Phenytoin	Canada Vigilance: 1		Canada Vigilance SIDER
73	Piroxicam			OFFSIDES
74	Prednisone acetate			OFFSIDES
75	Prednisone			SIDER
76	Propranolol		635611	CTD
77	Ramipril			OFFSIDES
78	Sodium Bicarbonate		6858403 8835608	CTD
79	Sodium Citrate		15331942	CTD
80	Sodium			SIDER
81	Stanozolol		15849280	CTD
82	Sulfate			OFFSIDES
83	Tacrolimus			SIDER
84	Tilidine			OFFSIDES
85	Tolazoline		7354974	CTD
86	Valproic Acid		10227223	CTD
87	Vincristine		582354	CTD OFFSIDES
88	Vitamin D			OFFSIDES
89	Vitamin K 1			OFFSIDES
90	Xipamide			OFFSIDES
91	Zoledronic Acid			OFFSIDES
92	alfacalcidol		20453404	CTD
93	boldenone		15849280	CTD
94	cisatracurium			OFFSIDES
95	fludarabine phosphate	Canada Vigilance: 1		Canada Vigilance
96	fosphenytoin			SIDER
97	moxonidine			OFFSIDES
98	pyrogastrone		3572225	CTD
99	testosterone 17-phenylpropionate		15849280	CTD
100	tulobuterol			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Acidosis	46.7%
2	Metabolic acidosis	46.7%
3	Acidosis, Lactic	34.4%
4	Ketosis	34.4%
5	Ketonuria	34.4%
6	Ketoacidosis	34.4%
7	Ketonemia	34.4%
8	Achlorhydria	31.1%
9	Calcium Metabolism Disorders	31%
10	Iron Metabolism Disorders	31%
11	Phosphorus Metabolism Disorders	31%
12	Water-Electrolyte Imbalance	31%
13	Lipid Metabolism Disorders	31%
14	Mitochondrial Diseases	31%
15	Glucose Metabolism Disorders	31%
16	Wasting Syndrome	27.9%
17	Hypercalcemia	26.7%
18	Hypocalcemia	26.7%
19	Milk-Alkali Syndrome	26.7%
20	Acidosis, Respiratory	23.1%
21	Diabetic Ketoacidosis	21.6%
22	Osteopenia	20.9%
23	Brain Diseases, Metabolic	20.5%
24	Amyloidosis	20%
25	Calcinosis	20%
26	Hyperglycemia	20%
27	Hyperinsulinism	20%
28	Hyperkalemia	20%
29	Hypernatremia	20%
30	Hypoglycemia	20%
31	Hypokalemia	20%
32	Hyponatremia	20%
33	Lipodystrophy	20%
34	Xanthomatosis	20%
35	Hypophosphatemia	20%
36	Dyslipidemias	20%
37	Iron Overload	20%
38	Xanthoma	20%
39	Nutrition Disorders	18.5%
40	Pseudohypoparathyroidism	18.1%
41	Rickets	17.3%
42	Renal tubular acidosis	16.2%
43	Brain Diseases, Metabolic, Inborn	15.9%
44	Leigh Disease	15.2%
45	Hyperhomocysteinemia	15.1%
46	Calciphylaxis	14.8%
47	Hemosiderosis	14.8%
48	Vascular calcification	14.8%
49	Hypolipoproteinemias	14.6%
50	Hyperlipoproteinemia Type IV	14.5%
51	Hyperlipoproteinemia Type V	14.5%
52	Diabetes Mellitus	14.3%
53	Carbamoyl-Phosphate Synthase I Deficiency Disease	13.8%
54	Lactose Intolerance	13.7%
55	Dehydration	13.6%
56	Lipomatosis	13.6%
57	Water Intoxication	13.6%
58	Werner Syndrome	13.6%
59	Hyperlipidemia, Familial Combined	13.4%
60	Amino Acid Metabolism, Inborn Errors	13.3%
61	Bloom Syndrome	13.3%
62	Carbohydrate Metabolism, Inborn Errors	13.3%
63	Metal Metabolism, Inborn Errors	13.3%
64	Osteoporosis	13.3%
65	Progeria	13.3%
66	Lysosomal Storage Diseases	13.3%
67	Bone Demineralization, Pathologic	13.3%
68	Cytochrome-c Oxidase Deficiency	13.3%
69	Peroxisomal Disorders	13.3%
70	Post-Traumatic Osteoporosis	13.3%
71	Celiac Disease	13.2%
72	Sprue, Tropical	13.2%
73	Steatorrhea	13.2%
74	Sprue	13.2%
75	Osteomalacia	13%
76	Hyperlipoproteinemia Type III	12.7%
77	Smith-Lemli-Opitz Syndrome	12.6%
78	Galactosemias	12.5%
79	Urea Cycle Disorders, Inborn	12.5%
80	Tyrosinemias	12.5%
81	Hypercholesterolemia	12.2%
82	Hyperlipoproteinemias	12.2%
83	Hypertriglyceridemia	12.2%
84	Congenital Hyperinsulinism	12.2%
85	Hypoalphalipoproteinemias	12%
86	Familial Hypophosphatemic Rickets	11.5%
87	Mitochondrial Encephalomyopathies	11.5%
88	Gaucher Disease	10.9%
89	Hyperphosphaturia	10.9%
90	Glycogen storage disease type II	10.6%
91	Homocystinuria	10.4%
92	Child Nutrition Disorders	10.3%
93	Hypervitaminosis A	10.3%
94	Infant Nutrition Disorders	10.3%
95	Malnutrition	10.3%
96	Mitochondrial Myopathies	10.2%
97	Myelinolysis, Central Pontine	10.1%
98	Glycosuria	9.9%
99	Reye Syndrome	9.9%
100	Adiposis Dolorosa	9.9%
101	Hepatic Encephalopathy	9.8%
102	Tay-Sachs Disease	9.8%
103	Nesidioblastosis	9.8%
104	Alkaptonuria	9.8%
105	Glycogen Storage Disease	9.8%
106	Hypophosphatasia	9.8%
107	Insulin Resistance	9.8%
108	Osteoporosis, Postmenopausal	9.8%
109	Propionic acidemia	9.8%
110	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
111	Cystinosis	9.8%
112	Amyloid Neuropathies, Familial	9.8%
113	Niemann-Pick Disease, Type C	9.3%
114	Neuronal Ceroid-Lipofuscinoses	9%
115	HIV Wasting Syndrome	8.8%
116	Fabry Disease	8.5%
117	HIV-Associated Lipodystrophy Syndrome	8.4%
118	MELAS Syndrome	8.2%
119	Renal Osteodystrophy	8.2%
120	Renal rickets	8.2%
121	Porphyrias, Hepatic	8.1%
122	Glycogen Storage Disease Type I	8.1%
123	Glycogen Storage Disease Type V	8.1%
124	Zellweger Syndrome	8%
125	Mucopolysaccharidosis III	8%
126	Adrenoleukodystrophy	8%
127	Necrobiosis Lipoidica Diabeticorum	7.9%
128	Menkes Kinky Hair Syndrome	7.9%
129	Fanconi Anemia	7.8%
130	Wernicke Encephalopathy	7.7%
131	Gestational Diabetes	7.7%
132	Latent Autoimmune Diabetes in Adults	7.7%
133	Diabetes Mellitus, Experimental	7.6%
134	Hepatolenticular Degeneration	7.4%
135	Nephrocalcinosis	7.4%
136	Tetany	7.4%
137	Refsum Disease	7.3%
138	Glycosuria, Renal	7.3%
139	Cerebral Amyloid Angiopathy	7.2%
140	Deficiency Diseases	6.7%
141	Starvation	6.7%
142	Refeeding Syndrome	6.7%
143	Friedreich Ataxia	6.5%
144	Familial Periodic Paralysis	6%
145	Primary amyloidosis	6%
146	Variegate Porphyria	5.9%
147	Acute intermittent porphyria	5.9%
148	Porphyria Cutanea Tarda	5.9%
149	Renal Aminoacidurias	5.8%
150	Fanconi Syndrome	5.8%
151	Pseudohypoaldosteronism	5.8%
152	Liddle Syndrome	5.8%
153	Kernicterus	5.7%
154	Kearns-Sayre syndrome	5.7%
155	Cockayne Syndrome	5.7%
156	Canavan Disease	5.4%
157	Alexander Disease	5.4%
158	Sjogren-Larsson Syndrome	5.4%
159	Mucopolysaccharidosis II	5.3%
160	Ataxia Telangiectasia	5.1%
161	Gout	5%
162	Amyotrophic Lateral Sclerosis	5%
163	Kwashiorkor	4.9%
164	Magnesium Deficiency	4.9%
165	Potassium Deficiency	4.9%
166	Protein Deficiency	4.9%
167	Avitaminosis	4.9%
168	Optic Atrophy, Hereditary, Leber	4.9%
169	Antley-Bixler Syndrome Phenotype	4.9%
170	Hypokalemic periodic paralysis	4.9%
171	Frontotemporal dementia	4.8%
172	Cystinuria	4.8%
173	Xeroderma Pigmentosum	4.5%
174	CREST Syndrome	4.2%
175	Ascorbic Acid Deficiency	4.1%
176	Vitamin A Deficiency	4.1%
177	Vitamin D Deficiency	4.1%
178	Vitamin E Deficiency	4.1%
179	Marasmus	4.1%
180	Arthritis, Gouty	4.1%
181	Albinism	3.7%
182	Folic Acid Deficiency	3.6%
183	Pellagra	3.6%
184	Thiamine Deficiency	3.6%
185	Vitamin B 12 Deficiency	3.6%
186	Vitamin B 6 Deficiency	3.6%
187	Pyridoxine Deficiency	3.6%
188	Beriberi	3.4%
189	Ichthyosis, X-Linked	3%
190	Obesity	2.6%
191	Obesity, Abdominal	2.4%
192	Anemia, Pernicious	2.3%
193	Vitamin K Deficiency	2.1%
194	Pediatric Obesity	1.9%
195	Scurvy	1.8%
196	Prader-Willi Syndrome	1.6%
197	Subacute Combined Degeneration	1.2%

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