MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Carbamoyl-Phosphate Synthase I Deficiency Disease

(UMLS:C0751753)

Definition:: A urea cycle disorder manifesting in infancy as lethargy, emesis, seizures, alterations of muscle tone, abnormal eye movements, and an elevation of serum ammonia. The disorder is caused by a reduction in the activity of hepatic mitochondrial CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA). (Menkes, Textbook of Child Neurology, 5th ed, pp50-1)
UMLS ID:: C0751753
MeSH ID:: D020165

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.937.249

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.100.940.249|C16.320.565.189.937.249

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.937.249|C18.452.648.100.940.249|C18.452.648.189.937.249|C18.452.660.097

Synonym(s)

Carbamoyl-Phosphate Synthase I Deficiency Disease

CPS1 (carbamoyl-phosphate synthetase 1) deficiency

Carbamoyl Phosphate Synthetase Deficiency

Carbamoyl phosphate synthetase deficiency

Carbamoyl-Phosphate Synthetase I Deficiency

Carbamoyl-phosphate synthetase 1 deficiency

Carbamoyl-phosphate synthetase I deficiency

carbamoyl phosphate synthetase deficiency

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Benzoic Acid	6623463	CTD
2	Sodium Benzoate	8438805	CTD
3	phenylacetic acid	8438805	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Tyrosinemias	54.9%
2	Leigh Disease	53.2%
3	Galactosemias	49%
4	Homocystinuria	45.5%
5	Adrenoleukodystrophy	45.1%
6	Hepatolenticular Degeneration	41.7%
7	Menkes Kinky Hair Syndrome	41.1%
8	Zellweger Syndrome	38.8%
9	Refsum Disease	38.4%
10	Glycogen storage disease type II	37.2%
11	MELAS Syndrome	35.1%
12	Hyperhomocysteinemia	34.5%
13	Smith-Lemli-Opitz Syndrome	34.3%
14	Pseudohypoparathyroidism	33.5%
15	Carbohydrate Metabolism, Inborn Errors	32.1%
16	Metal Metabolism, Inborn Errors	32.1%
17	Progeria	32.1%
18	Lysosomal Storage Diseases	32.1%
19	Peroxisomal Disorders	32.1%
20	Cytochrome-c Oxidase Deficiency	30.6%
21	Hyperphosphaturia	30.6%
22	Gaucher Disease	30.2%
23	Fabry Disease	28.9%
24	Wasting Syndrome	28.3%
25	Alkaptonuria	28.3%
26	Propionic acidemia	28.3%
27	Mitochondrial Encephalomyopathies	26.6%
28	Canavan Disease	26.4%
29	Alexander Disease	26.4%
30	Lactose Intolerance	26.3%
31	Albinism	25.5%
32	Hypolipoproteinemias	25%
33	Hypercalcemia	24.7%
34	Hypocalcemia	24.7%
35	Milk-Alkali Syndrome	24.7%
36	Amyloid Neuropathies, Familial	24.6%
37	Familial Hypophosphatemic Rickets	24.5%
38	Niemann-Pick Disease, Type C	24.2%
39	Brain Diseases, Metabolic, Inborn	24%
40	Hyperlipoproteinemia Type IV	23.9%
41	Hyperlipoproteinemia Type V	23.9%
42	Acid-Base Imbalance	23.7%
43	Calcium Metabolism Disorders	23.7%
44	Iron Metabolism Disorders	23.7%
45	Phosphorus Metabolism Disorders	23.7%
46	Water-Electrolyte Imbalance	23.7%
47	Lipid Metabolism Disorders	23.7%
48	Glucose Metabolism Disorders	23.7%
49	Tay-Sachs Disease	23.4%
50	Hyperlipidemia, Familial Combined	23%
51	Lipodystrophy	22.3%
52	Werner Syndrome	22.2%
53	Hyperlipoproteinemia Type III	22%
54	Myelinolysis, Central Pontine	21.9%
55	Rickets	21.6%
56	Urea Cycle Disorders, Inborn	21.4%
57	Osteopenia	21.3%
58	Neuronal Ceroid-Lipofuscinoses	21%
59	Renal tubular acidosis	20.8%
60	Mucopolysaccharidosis III	20.5%
61	Reye Syndrome	20.4%
62	Mucopolysaccharidosis II	20.4%
63	Hepatic Encephalopathy	20.3%
64	Glycogen Storage Disease	19.7%
65	Hypophosphatasia	19.7%
66	Dihydropyrimidine Dehydrogenase Deficiency	19.7%
67	Cystinosis	19.7%
68	Amino Acid Metabolism, Inborn Errors	19.5%
69	Carbamoyl-Phosphate Synthase I Deficiency Disease	19.4%
70	Ichthyosis, X-Linked	18.9%
71	Friedreich Ataxia	18.7%
72	Wernicke Encephalopathy	18.1%
73	Cockayne Syndrome	17.9%
74	Glycosuria, Renal	17.8%
75	Hypoalphalipoproteinemias	17.5%
76	Mitochondrial Myopathies	17.2%
77	Kernicterus	17.1%
78	Familial Periodic Paralysis	17%
79	Sjogren-Larsson Syndrome	16.9%
80	Mitochondrial Diseases	16.4%
81	Ataxia Telangiectasia	16.3%
82	Brain Diseases, Metabolic	16.2%
83	Optic Atrophy, Hereditary, Leber	16.2%
84	Renal Aminoacidurias	16.1%
85	Fanconi Syndrome	16.1%
86	Pseudohypoaldosteronism	16.1%
87	Liddle Syndrome	16.1%
88	Congenital Hyperinsulinism	16%
89	Antley-Bixler Syndrome Phenotype	15.7%
90	Gout	15%
91	Kearns-Sayre syndrome	14.9%
92	Porphyrias, Hepatic	14.7%
93	Nutrition Disorders	14.6%
94	Fanconi Anemia	14.5%
95	Osteomalacia	14.2%
96	Bloom Syndrome	14.1%
97	Acidosis	13.8%
98	Alkalosis	13.8%
99	Amyloidosis	13.8%
100	Calcinosis	13.8%
101	Hyperglycemia	13.8%
102	Hyperinsulinism	13.8%
103	Hyperkalemia	13.8%
104	Hypernatremia	13.8%
105	Hypoglycemia	13.8%
106	Hypokalemia	13.8%
107	Hyponatremia	13.8%
108	Xanthomatosis	13.8%
109	Hypophosphatemia	13.8%
110	Metabolic acidosis	13.8%
111	Dyslipidemias	13.8%
112	Iron Overload	13.8%
113	Xanthoma	13.8%
114	Glycogen Storage Disease Type I	13.6%
115	Glycogen Storage Disease Type V	13.6%
116	Diabetes Mellitus	12.6%
117	Diabetic Ketoacidosis	12.5%
118	Dehydration	12.4%
119	Lipomatosis	12.4%
120	Water Intoxication	12.4%
121	HIV Wasting Syndrome	12.4%
122	Achlorhydria	12.4%
123	Osteoporosis	12.4%
124	Bone Demineralization, Pathologic	12.4%
125	Post-Traumatic Osteoporosis	12.4%
126	Celiac Disease	12.3%
127	Sprue, Tropical	12.3%
128	Steatorrhea	12.3%
129	Sprue	12.3%
130	Xeroderma Pigmentosum	11.9%
131	Hypokalemic periodic paralysis	11.6%
132	Renal Osteodystrophy	11.2%
133	Renal rickets	11.2%
134	Aicardi's syndrome	11.2%
135	Cystinuria	11.1%
136	Glycosuria	11.1%
137	HIV-Associated Lipodystrophy Syndrome	11.1%
138	Nesidioblastosis	11.1%
139	Cystic Fibrosis	10.9%
140	Myasthenic Syndromes, Congenital	10.6%
141	CHARGE Syndrome	10.4%
142	Arthritis, Gouty	10.3%
143	Necrobiosis Lipoidica Diabeticorum	10.1%
144	Neoplastic Syndromes, Hereditary	10%
145	Multiple Epiphyseal Dysplasia	9.7%
146	Osteochondrodysplasias	9.7%
147	Pelger-Huet Anomaly	9.7%
148	Amyotrophic Lateral Sclerosis	9.7%
149	Nail-Patella Syndrome	9.5%
150	Variegate Porphyria	9.2%
151	Acute intermittent porphyria	9.2%
152	Porphyria Cutanea Tarda	9.2%
153	Muscular Dystrophy	9.2%
154	Prader-Willi Syndrome	9.1%
155	Muscular Dystrophy, Duchenne	9%
156	Acidosis, Lactic	9%
157	Calciphylaxis	9%
158	Hemosiderosis	9%
159	Ketosis	9%
160	Ketonuria	9%
161	Ketoacidosis	9%
162	Ketonemia	9%
163	Vascular calcification	9%
164	Dwarfism	9%
165	Anemia, Sickle Cell	8.8%
166	Thalassemia	8.8%
167	Osteogenesis Imperfecta	8.8%
168	Alstrom Syndrome	8.7%
169	Dystonia Musculorum Deformans	8.7%
170	Smith-Magenis syndrome	8.7%
171	Huntington Disease	8.5%
172	Kartagener Syndrome	8.3%
173	Cerebral Amyloid Angiopathy	8.3%
174	Marchiafava-Bignami Disease	8.3%
175	Tuberous Sclerosis	8.2%
176	Marfan Syndrome	8.2%
177	Fragile X Syndrome	8.2%
178	Beckwith-Wiedemann Syndrome	8.1%
179	Wolf-Hirschhorn Syndrome	8.1%
180	Autoimmune Lymphoproliferative Syndrome	8.1%
181	Acidosis, Respiratory	8%
182	Adiposis Dolorosa	8%
183	Alkalosis, Respiratory	8%
184	Insulin Resistance	8%
185	Osteoporosis, Postmenopausal	8%
186	Tetany	8%
187	Angioedemas, Hereditary	7.9%
188	Myotonic Dystrophy	7.9%
189	Child Nutrition Disorders	7.9%
190	Hypervitaminosis A	7.9%
191	Infant Nutrition Disorders	7.9%
192	Malnutrition	7.9%
193	Dandy-Walker Syndrome	7.9%
194	Cri-du-Chat Syndrome	7.7%
195	Down Syndrome	7.7%
196	Trisomy 21	7.7%
197	Holoprosencephaly	7.7%
198	Meningoencephalitis	7.6%
199	Wiskott-Aldrich Syndrome	7.5%
200	Gestational Diabetes	7.3%
201	Latent Autoimmune Diabetes in Adults	7.3%
202	Diabetes Mellitus, Experimental	7.3%
203	Nephrocalcinosis	7.2%
204	Kallmann Syndrome	7.2%
205	Encephalomyelitis	7%
206	Deformity	7%
207	Subdural Effusion	7%
208	Dementia, Vascular	6.8%
209	Ectodermal Dysplasia	6.8%
210	Aplasia Cutis Congenita	6.8%
211	Rubinstein-Taybi Syndrome	6.8%
212	Pneumocephalus	6.7%
213	Frontotemporal dementia	6.7%
214	Brain Abscess	6.7%
215	Primary amyloidosis	6.6%
216	Leukomalacia, Periventricular	6.6%
217	Hypercholesterolemia	6.6%
218	Hyperlipoproteinemias	6.6%
219	Hypertriglyceridemia	6.6%
220	Lafora Disease	6.6%
221	Unverricht-Lundborg Syndrome	6.6%
222	Multiple System Atrophy	6.5%
223	Akinetic Mutism	6.3%
224	Anoxic Encephalopathy	6.3%
225	Basal Ganglia Diseases	6.3%
226	Brain Damage, Chronic	6.3%
227	Cerebellar Diseases	6.3%
228	Encephalitis	6.3%
229	Encephalomalacia	6.3%
230	Epilepsy	6.3%
231	Hydrocephalus	6.3%
232	Congenital Hydrocephalus	6.3%
233	Hypothalamic Diseases	6.3%
234	Thalamic Diseases	6.3%
235	Intracranial Hypertension	6.3%
236	Aura	6.3%
237	Leukoencephalopathy	6.3%
238	Neuroaxonal Dystrophies	6.3%
239	Headache Disorders	6.3%
240	Intracranial Hypotension	6.3%
241	Brain Edema	6.3%
242	Brain Hypoxia	6.3%
243	Aqueductal Stenosis	6.3%
244	Fetal Diseases	6.3%
245	Williams Syndrome	6.2%
246	Familial Mediterranean Fever	6%
247	Rett Syndrome	6%
248	Lewy Body Disease	5.9%
249	Polycystic Kidney Diseases	5.9%
250	Brain Injuries	5.8%
251	Brain Neoplasms	5.8%
252	Ocular Motility Disorders	5.7%
253	Cyclophoria	5.7%
254	Cerebrovascular Disorders	5.7%
255	Cerebrovascular Insufficiency	5.7%
256	Dementia	5.7%
257	Basal Ganglia Cerebrovascular Disease	5.6%
258	CREST Syndrome	5.6%
259	Parkinsonian Disorders	5.5%
260	Retinal Dysplasia	5.5%
261	Primary Ciliary Dyskinesia	5.5%
262	Aniridia	5.5%
263	Epilepsy, Post-Traumatic	5.5%
264	Myotonia Congenita	5.4%
265	Epidermolysis Bullosa	5.4%
266	Subacute Combined Degeneration	5.2%
267	Sickle Cell Trait	5.2%
268	Brain Death	5.2%
269	Meningitis	5.2%
270	Movement Disorders	5.2%
271	Pachymeningitis	5.2%
272	Spinal Cord Diseases	5.2%
273	Duane Retraction Syndrome	5.1%
274	Epidural Abscess	5.1%
275	Welander Distal Myopathy	5.1%
276	Amblyopia	5%
277	Posterior Leukoencephalopathy Syndrome	5%
278	Posterior reversible encephalopathy syndrome	5%
279	Meconium Aspiration Syndrome	5%
280	Cutis Laxa	4.9%
281	Retinitis Pigmentosa	4.9%
282	Pigmentary retinopathy	4.9%
283	Porokeratosis	4.9%
284	Keratoderma, Palmoplantar	4.9%
285	Chronic granulomatous disease	4.8%
286	Myelitis	4.8%
287	Mobius Syndrome	4.8%
288	Central Nervous System Infection	4.7%
289	Pseudoxanthoma Elasticum	4.7%
290	Progressive supranuclear palsy	4.7%
291	Deficiency Diseases	4.6%
292	Starvation	4.6%
293	Refeeding Syndrome	4.6%
294	Stiff-Person Syndrome	4.5%
295	Acute Chest Syndrome	4.5%
296	Vascular Headaches	4.5%
297	Hypoxia-Ischemia, Brain	4.5%
298	Meige Syndrome	4.4%
299	Cerebral Ventriculitis	4.4%
300	Amnesia, Transient Global	4.4%
301	Peutz-Jeghers Syndrome	4.4%
302	Thrombasthenia	4.4%
303	Antithrombin III Deficiency	4.4%
304	Protein C Deficiency	4.4%
305	Afibrinogenemia	4.4%
306	Factor VII Deficiency	4.4%
307	Factor X Deficiency	4.4%
308	Factor XII Deficiency	4.4%
309	Hemophilia A	4.4%
310	Activated Protein C Resistance	4.4%
311	Factor II deficiency	4.4%
312	Factor VIII Deficiency	4.4%
313	Factor V deficiency	4.4%
314	Factor XI Deficiency	4.4%
315	Hypoprothrombinemias	4.4%
316	Anemia, Diamond-Blackfan	4.4%
317	Charcot-Marie-Tooth Disease	4.3%
318	Leukoencephalopathy, Progressive Multifocal	4.3%
319	Parkinson Disease	4.3%
320	Cerebellar Neoplasms	4.3%
321	Neuroleptic Malignant Syndrome	4.2%
322	Xeroderma	4.2%
323	Multiple Endocrine Neoplasia	4.1%
324	Congenital Hypothyroidism	4.1%
325	Dermatitis, Atopic	4.1%
326	Basal Cell Nevus Syndrome	4.1%
327	Lupus Vasculitis, Central Nervous System	4%
328	Creutzfeldt-Jakob disease	4%
329	Prion Diseases	4%
330	Limbic Encephalitis	4%
331	Classical Lissencephalies and Subcortical Band Heterotopias	3.9%
332	Behcet Syndrome	3.8%
333	Myoclonic Epilepsy	3.7%
334	Epilepsy, Temporal Lobe	3.7%
335	Epilepsy, Rolandic	3.7%
336	Benign Rolandic Epilepsy	3.7%
337	Spinal Cord Injuries	3.7%
338	Striatonigral Degeneration	3.6%
339	Abdominal Cramps	3.6%
340	Abnormalities, Drug-Induced	3.6%
341	Amniotic Band Syndrome	3.6%
342	Asphyxia Neonatorum	3.6%
343	Infant, Premature, Diseases	3.6%
344	Situs Inversus	3.6%
345	Infantile Colic	3.6%
346	Spinal Muscular Atrophy	3.6%
347	Progressive Muscular Atrophy	3.6%
348	Toxoplasmosis, Congenital	3.6%
349	Dural Arteriovenous Fistula	3.6%
350	Asterixis	3.6%
351	Ballismus	3.6%
352	Presenile dementia	3.5%
353	Senile dementia	3.5%
354	Vasculitis, Central Nervous System	3.5%
355	Cerebral Palsy	3.5%
356	Epilepsies, Partial	3.5%
357	Epilepsy, Generalized	3.5%
358	Pseudotumor Cerebri	3.5%
359	Hypertensive Encephalopathy	3.5%
360	Simple Partial Seizures	3.5%
361	Epilepsy, Reflex	3.5%
362	Headache Disorders, Primary	3.5%
363	Headache Disorders, Secondary	3.5%
364	Medication overuse headache	3.5%
365	Polycystic Kidney, Autosomal Dominant	3.5%
366	Poliomyelitis	3.5%
367	Hyperkeratosis, Epidermolytic	3.4%
368	Basal Ganglia Hemorrhage	3.4%
369	Central Nervous System Cysts	3.4%
370	Cranial nerve diseases	3.4%
371	Demyelinating Diseases	3.4%
372	Demyelination	3.4%
373	Neuromuscular Diseases	3.4%
374	Chronobiology Disorders	3.4%
375	Toxoplasmosis, Cerebral	3.4%
376	Meningitis, Bacterial	3.4%
377	Meningitis, Fungal	3.4%
378	Leukoencephalitis, Acute Hemorrhagic	3.4%
379	Brain Hemorrhage, Traumatic	3.4%
380	Ophthalmoplegic Migraine	3.4%
381	Shy-Drager Syndrome	3.4%
382	Obesity	3.3%
383	Chronic Fatigue Syndrome	3.3%
384	Hydranencephaly	3.3%
385	Neural Tube Defects	3.3%
386	Tethered Cord Syndrome	3.3%
387	Iniencephaly	3.3%
388	Craniorachischisis	3.3%
389	Exencephaly	3.3%
390	Septo-Optic Dysplasia	3.3%
391	Cortical Dysplasia	3.3%
392	Malformations of Cortical Development	3.3%
393	Congenital nystagmus	3.3%
394	Eye Abnormalities	3.3%
395	Cardiovascular Abnormalities	3.3%
396	Anencephaly	3.3%
397	Miller Fisher Syndrome	3.3%
398	Skin Abnormalities	3.3%
399	Lymphatic Abnormalities	3.3%
400	Congenital Microtia	3.3%
401	Anemia, Neonatal	3.2%
402	Persistent Fetal Circulation Syndrome	3.2%
403	Nephroblastoma	3.2%
404	Congenital diaphragmatic hernia	3.2%
405	Umbilical hernia	3.2%
406	Paraneoplastic Cerebellar Degeneration	3.2%
407	Restless Legs Syndrome	3.2%
408	Brain Injuries, Diffuse	3.2%
409	Traumatic Brain Injury	3.2%
410	Cerebellar Ataxia	3.2%
411	Supratentorial Neoplasms	3.2%
412	Pituitary Diseases	3.2%
413	Carotid Artery Injuries	3.2%
414	Pituitary Adenoma	3.1%
415	Pituitary Neoplasms	3.1%
416	Carotid Artery Diseases	3.1%
417	Brain Ischemia	3.1%
418	Cerebrovascular accident	3.1%
419	Kluver-Bucy Syndrome	3.1%
420	Vasospasm, Intracranial	3.1%
421	Intracranial Arterial Diseases	3.1%
422	Motor Neuron Disease	3.1%
423	Trauma, Nervous System	3.1%
424	Pituitary Apoplexy	3.1%
425	Myelitis, Transverse	3.1%
426	Brain Infarction	3.1%
427	Nervous System Neoplasms	3%
428	Neurologic Manifestations	3%
429	Neurotoxicity Syndromes	3%
430	Persistent Vegetative State	3%
431	Adenomatous Polyposis Coli	3%
432	Urogenital Abnormalities	3%
433	Akathisia, Drug-Induced	3%
434	Kwashiorkor	3%
435	Magnesium Deficiency	3%
436	Potassium Deficiency	3%
437	Protein Deficiency	3%
438	Avitaminosis	3%
439	Neonatal Abstinence Syndrome	3%
440	MPTP Poisoning	2.9%
441	Fetal Growth Retardation	2.9%
442	Fetal Hypoxia	2.9%
443	Fetal Alcohol Spectrum Disorders	2.9%
444	Opsoclonus-Myoclonus Syndrome	2.9%
445	Spinal Cord Neoplasms	2.9%
446	Syphilis, Congenital	2.9%
447	Polyradiculoneuropathy	2.9%
448	Polyradiculoneuritis	2.9%
449	Papillon-Lefevre Disease	2.9%
450	Encephalomyelitis, Acute Disseminated	2.9%
451	Intracranial Embolism and Thrombosis	2.8%
452	Sleep Wake Disorders	2.8%
453	Arachnoiditis	2.7%
454	Aseptic Meningitis	2.7%
455	Syringomyelia	2.7%
456	Essential Tremor	2.7%
457	Familial Tremor	2.7%
458	Pneumorrhachis	2.7%
459	Writer's Cramp	2.7%
460	Chorioamnionitis	2.7%
461	Dyskinesia, Drug-Induced	2.6%
462	Hydrops Fetalis	2.6%
463	Auditory Perceptual Disorders	2.5%
464	Juvenile Myoclonic Epilepsy	2.5%
465	Myoclonic Epilepsies, Progressive	2.5%
466	Abnormalities, Radiation-Induced	2.4%
467	Central Nervous System Fungal Infections	2.4%
468	Conus Medullaris Syndrome	2.4%
469	Spinal Cord Vascular Diseases	2.4%
470	Multiple Endocrine Neoplasia Type 1	2.4%
471	Turner Syndrome	2.4%
472	Obesity, Abdominal	2.4%
473	Maxillofacial Abnormalities	2.4%
474	Dextrocardia	2.4%
475	Putaminal Hemorrhage	2.3%
476	AIDS Dementia Complex	2.3%
477	Autonomic Dysreflexia	2.3%
478	Complex Regional Pain Syndromes	2.3%
479	Moyamoya Disease	2.3%
480	Klinefelter Syndrome	2.3%
481	Ophthalmia Neonatorum	2.2%
482	Central Nervous System Bacterial Infections	2.2%
483	Lambert-Eaton Myasthenic Syndrome	2.2%
484	Ascorbic Acid Deficiency	2.2%
485	Tuberculosis, Meningeal	2.2%
486	Vitamin A Deficiency	2.2%
487	Vitamin D Deficiency	2.2%
488	Vitamin E Deficiency	2.2%
489	Marasmus	2.2%
490	Pediatric Obesity	2.2%
491	Infarction, Middle Cerebral Artery	2.1%
492	Infarction, Anterior Cerebral Artery	2.1%
493	Infarction, Posterior Cerebral Artery	2.1%
494	Peripheral Nerve Injuries	2.1%
495	Myasthenia Gravis	2.1%
496	Post-Traumatic Headache	2.1%
497	Tension Headache	2.1%
498	Epilepsy, Complex Partial	2.1%
499	Migraine Disorders	2.1%
500	Abdominal Migraine	2.1%
501	Status Migrainosus	2.1%
502	Cervicogenic Headache	2.1%
503	Scimitar Syndrome	2%
504	Cerebral Infarction	2%
505	Brain Stem Infarctions	2%
506	Guillain-Barre Syndrome	2%
507	Vertebral Artery Dissection	2%
508	Prune Belly Syndrome	2%
509	Twins, Conjoined	2%
510	Waardenburg Syndrome	2%
511	Sleep Disorders, Circadian Rhythm	2%
512	Scrapie	1.9%
513	Central Cord Syndrome	1.9%
514	Chorea	1.9%
515	Botulism	1.9%
516	Diffuse Axonal Injury	1.9%
517	Brain Stem Neoplasms	1.9%
518	Empty Sella Syndrome	1.9%
519	Hyperpituitarism	1.9%
520	Hypopituitarism	1.9%
521	Hypophysitis	1.9%
522	Subarachnoid Hemorrhage, Traumatic	1.9%
523	Carotid Artery, Internal, Dissection	1.9%
524	Meningomyelocele	1.9%
525	Spina Bifida	1.9%
526	Cerebral Arterial Diseases	1.9%
527	Vertebrobasilar Insufficiency	1.9%
528	Basilar Artery Stenosis	1.9%
529	Vertebral Artery Stenosis	1.9%
530	Intracranial Hemorrhage, Hypertensive	1.9%
531	Transient Cerebral Ischemia	1.9%
532	Subacute Sclerosing Panencephalitis	1.9%
533	Denys-Drash Syndrome	1.9%
534	POEMS Syndrome	1.8%
535	Microcephaly	1.8%
536	Macrocephaly	1.8%
537	Anophthalmos	1.8%
538	Anus, Imperforate	1.8%
539	Microphthalmos	1.8%
540	Paralysis, Obstetric	1.8%
541	Retinopathy of Prematurity	1.8%
542	Limb Deformities, Congenital	1.8%
543	Craniofacial Abnormalities	1.8%
544	Anorectal Malformations	1.8%
545	Folic Acid Deficiency	1.8%
546	Pellagra	1.8%
547	Thiamine Deficiency	1.8%
548	Vitamin B 12 Deficiency	1.8%
549	Vitamin B 6 Deficiency	1.8%
550	Pyridoxine Deficiency	1.8%
551	Brain Concussion	1.8%
552	Bronchopulmonary Dysplasia	1.8%
553	Neuromyelitis Optica	1.8%
554	Vitamin K Deficiency	1.8%
555	Meningitis, Cryptococcal	1.8%
556	Meningitis, Listeria	1.7%
557	Brain Contusion	1.7%
558	Meningitis, Haemophilus	1.7%
559	Meningitis, Pneumococcal	1.7%
560	Giant Cell Arteritis	1.7%
561	Temporal Arteritis	1.7%
562	Dysautonomia	1.7%
563	Vagus Nerve Disorder	1.7%
564	Glossopharyngeal Neuralgia	1.7%
565	Abducens Nerve Diseases	1.7%
566	Heavy Metal Poisoning, Nervous System	1.7%
567	Neuromuscular Junction Diseases	1.7%
568	Tauopathies	1.7%
569	Trochlear Nerve Diseases	1.7%
570	Peripheral Nervous System Diseases	1.7%
571	Meningocele	1.7%
572	Encephalocele	1.7%
573	Olfactory Nerve Injuries	1.7%
574	Carotid Stenosis	1.7%
575	Intracranial Aneurysm	1.7%
576	Intracranial Arteriosclerosis	1.7%
577	Cerebral Atherosclerosis	1.7%
578	Subarachnoid Hemorrhage	1.7%
579	Cerebral Arteriosclerosis	1.7%
580	Cerebral Hemorrhage	1.7%
581	Cerebral Thrombosis	1.7%
582	Intracranial Embolism	1.7%
583	Intracranial Thrombosis	1.7%
584	Blepharophimosis	1.6%
585	Laryngostenosis	1.6%
586	Mouth Abnormalities	1.6%
587	Respiratory Distress Syndrome, Newborn	1.6%
588	Esophageal Atresia	1.6%
589	Intestinal Atresia	1.6%
590	Horseshoe Kidney	1.6%
591	Pectus excavatum	1.6%
592	Klippel-Feil Syndrome	1.6%
593	Gastroschisis	1.6%
594	Synostosis	1.6%
595	Horner Syndrome	1.6%
596	Acrodermatitis	1.6%
597	Lymphangiectasis, Intestinal	1.6%
598	Gianotti-Crosti Syndrome	1.6%
599	Progressive bulbar palsy	1.6%
600	Bulbar palsy	1.6%
601	Craniosynostosis	1.6%
602	Syndactyly	1.6%
603	Brachycephaly	1.6%
604	Torticollis	1.6%
605	Beriberi	1.6%
606	Myopathy	1.6%
607	Optic Neuropathy	1.6%
608	Facial Nerve Injuries	1.5%
609	Facial Nerve Diseases	1.5%
610	Craniocerebral Trauma	1.5%
611	Parasomnia	1.5%
612	Dyssomnias	1.5%
613	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.5%
614	Vestibulocochlear Nerve Diseases	1.5%
615	Decerebrate State	1.5%
616	Hemiparesis	1.5%
617	Meningism	1.5%
618	Paresis	1.5%
619	Seizures	1.5%
620	Sensation Disorders	1.5%
621	Central Nervous System Neoplasms	1.5%
622	Complex partial seizures	1.5%
623	Monoparesis	1.5%
624	Neurogenic Inflammation	1.5%
625	Gait Disorders, Neurologic	1.5%
626	Neuromuscular Manifestations	1.5%
627	Sweating, Gustatory	1.5%
628	Auriculotemporal Syndrome	1.5%
629	Causalgia	1.5%
630	Carotid Artery Thrombosis	1.5%
631	Porencephaly	1.5%
632	Lateral Medullary Syndrome	1.5%
633	Noonan Syndrome	1.5%
634	Acrocephalosyndactylia	1.5%
635	Arthrogryposis	1.5%
636	Choanal Atresia	1.5%
637	Tracheobronchomegaly	1.5%
638	Laryngocele	1.5%
639	Choledochal Cyst	1.5%
640	Hermaphroditism	1.5%
641	Disorders of Sex Development	1.5%
642	Jet Lag Syndrome	1.5%
643	Cryptorchidism	1.5%
644	Hypospadias	1.5%
645	Alice in Wonderland Syndrome	1.5%
646	Multiple Sclerosis	1.5%
647	Scurvy	1.4%
648	Myasthenia Gravis, Autoimmune, Experimental	1.4%
649	Anemia, Pernicious	1.4%
650	Pupil Disorders	1.4%
651	Neurobehavioral Manifestations	1.4%
652	Cluster Headache	1.4%
653	Migraine with Aura	1.4%
654	Familial Hemiplegic Migraine	1.4%
655	Chronic Paroxysmal Hemicrania	1.4%
656	SUNCT Syndrome	1.4%
657	Paroxysmal Hemicrania	1.4%
658	Paraneoplastic Encephalomyelitis	1.4%
659	Uveomeningoencephalitic Syndrome	1.4%
660	Sturge-Weber Syndrome	1.4%
661	Vertigo	1.4%
662	Alcohol-Induced Disorders, Nervous System	1.4%
663	Laryngomalacia	1.4%
664	Pectus carinatum	1.4%
665	Bladder Exstrophy	1.4%
666	Epispadias	1.4%
667	Multicystic Dysplastic Kidney	1.4%
668	Spinal Cord Ischemia	1.3%
669	Ophthalmoplegia	1.3%
670	External Ophthalmoplegia	1.3%
671	Tuberculosis, Central Nervous System	1.3%
672	Cleft Palate	1.3%
673	Voice Disorders	1.3%
674	Voice Disturbance	1.3%
675	Choroid Plexus Papilloma	1.3%
676	Jaw Abnormalities	1.3%
677	Reflex Sympathetic Dystrophy	1.2%
678	Nocturnal Myoclonus Syndrome	1.2%
679	Hyperprolactinemia	1.2%
680	Subclavian Steal Syndrome	1.2%
681	Pick Disease of the Brain	1.2%
682	Vocal Cord Paralysis	1.2%
683	Neuroaspergillosis	1.2%
684	West Nile Fever	1.2%
685	Hematoma, Subdural	1.2%
686	Hematoma, Epidural, Cranial	1.2%
687	Dermal Sinus	1.2%
688	Spina Bifida Cystica	1.2%
689	Spina Bifida Occulta	1.2%
690	Lissencephaly	1.2%
691	Polymicrogyria	1.2%
692	Pachygyria	1.2%
693	Schizencephaly	1.2%
694	Periventricular Nodular Heterotopia	1.2%
695	Reflex, Abnormal	1.1%
696	Hyporeflexia	1.1%
697	Hyperreflexia	1.1%
698	Pseudorabies	1.1%
699	Acromegaly	1.1%
700	Acrodynia	1.1%
701	Alcohol Withdrawal Seizures	1.1%
702	Tardive Dyskinesia	1.1%
703	Sinus Thrombosis, Intracranial	1.1%
704	Neurosyphilis	1.1%
705	Amelia	1.1%
706	Arachnodactyly	1.1%
707	Ectopia Cordis	1.1%
708	Ectromelia	1.1%
709	Hemimelia	1.1%
710	Phocomelia	1.1%
711	Sirenomelia	1.1%
712	Polydactyly	1.1%
713	Brachydactyly	1.1%
714	Plagiocephaly	1.1%
715	Lower Extremity Deformities, Congenital	1.1%
716	Upper Extremity Deformities, Congenital	1.1%
717	Single umbilical artery	1.1%
718	Poland Syndrome	1.1%
719	Cerebrospinal Fluid Otorrhea	1%
720	Cerebrospinal Fluid Rhinorrhea	1%
721	Neuritis, Autoimmune, Experimental	1%
722	Gait Ataxia	1%
723	Lyme Neuroborreliosis	1%
724	Aortic coarctation	1%
725	Cor Triatriatum	1%
726	Coronary Vessel Anomalies	1%
727	Dental Enamel Hypoplasia	1%
728	Patent ductus arteriosus	1%
729	Ebstein Anomaly	1%
730	Heart Septal Defects	1%
731	Hyaline Membrane Disease	1%
732	Hypodontia	1%
733	Macrostomia	1%
734	Microstomia	1%
735	Tetralogy of Fallot	1%
736	Transposition of Great Vessels	1%
737	Hypoplastic Left Heart Syndrome	1%
738	May-Thurner Syndrome	1%
739	Craniofacial Dysostosis	1%
740	Wolff-Parkinson-White Syndrome	1%
741	Akathisia	0.9%
742	Restlessness	0.9%
743	Psychomotor Agitation	0.9%
744	Prolactinoma	0.9%
745	Growth Hormone-Secreting Pituitary Adenoma	0.9%
746	Acoustic Neuroma	0.9%
747	Neuritis	0.9%
748	Polyneuritis	0.9%
749	Radiculitis	0.9%
750	Polyneuropathy	0.9%
751	Mononeuritis	0.9%
752	Mononeuropathies	0.9%
753	Brachial Plexus Neuropathies	0.9%
754	Radiculopathy	0.9%
755	Mononeuropathy Multiplex	0.9%
756	Nerve Root Compression	0.9%
757	Brachial Plexus Neuritis	0.9%
758	Neuralgic Amyotrophy	0.9%
759	Coma, Post-Head Injury	0.9%
760	Long QT Syndrome	0.9%
761	Platybasia	0.9%
762	Tricuspid Atresia	0.9%
763	Arrhythmogenic Right Ventricular Dysplasia	0.9%
764	Gonadal Dysgenesis	0.9%
765	Bronchomalacia	0.9%
766	Adrenogenital Syndrome	0.9%
767	Tracheomalacia	0.9%
768	Ovotesticular Disorders of Sex Development	0.9%
769	Micrognathism	0.9%
770	Pierre Robin Syndrome	0.9%
771	Hyperandrogenism	0.9%
772	Optic Nerve Glioma	0.8%
773	Cavernous Sinus Thrombosis	0.8%
774	Sagittal Sinus Thrombosis	0.8%
775	Hematoma, Subdural, Intracranial	0.8%
776	Hematoma, Subdural, Chronic	0.8%
777	Hematoma, Subdural, Acute	0.8%
778	Myositis	0.8%
779	Optic Atrophy	0.8%
780	Optic Neuritis	0.8%
781	Papilledema	0.8%
782	Strabismus	0.8%
783	Tolosa-Hunt Syndrome	0.8%
784	Isaacs syndrome	0.8%
785	Arsenic Poisoning	0.8%
786	Myotonic Disorders	0.8%
787	Diabetic Neuropathies	0.8%
788	Facial Injuries	0.8%
789	Facial Neuralgia	0.8%
790	Diabetic Amyotrophy	0.8%
791	Diabetic Autonomic Neuropathy	0.8%
792	Sleep Talking	0.8%
793	Manganese Poisoning	0.8%
794	Sleep Disorders, Intrinsic	0.8%
795	Orthostatic intolerance	0.8%
796	Retrognathia	0.8%
797	Anosmia	0.8%
798	Ataxia	0.8%
799	Athetosis	0.8%
800	Catalepsy	0.8%
801	Dystonia	0.8%
802	Hemiplegia	0.8%
803	Locked-In Syndrome	0.8%
804	Meningeal Neoplasms	0.8%
805	Muscle Hypertonia	0.8%
806	Muscle hypotonia	0.8%
807	Myoclonus	0.8%
808	Myotonia	0.8%
809	Neuralgia	0.8%
810	Paraplegia	0.8%
811	Pseudobulbar Palsy	0.8%
812	Quadriplegia	0.8%
813	Spasm	0.8%
814	Spastic Paraplegia	0.8%
815	Status Epilepticus	0.8%
816	Taste Disorders	0.8%
817	Tremor	0.8%
818	Monoplegia	0.8%
819	Hypokinesia	0.8%
820	Paraparesis	0.8%
821	Bradykinesia	0.8%
822	Waxy flexibility	0.8%
823	Action Tremor	0.8%
824	Resting Tremor	0.8%
825	Dysosmia	0.8%
826	Quadriparesis	0.8%
827	Mercury Poisoning, Nervous System	0.8%
828	Olfaction Disorders	0.8%
829	Myokymia	0.8%
830	Lead Poisoning, Nervous System	0.8%
831	Vestibular Neuronitis	0.8%
832	Somatosensory Disorders	0.8%
833	Neuropathic pain	0.8%
834	Hyperkinesia	0.8%
835	Intention tremor	0.8%
836	Gait Apraxia	0.8%
837	Multiple Sclerosis, Chronic Progressive	0.8%
838	Multiple Sclerosis, Relapsing-Remitting	0.8%
839	Anterior Spinal Artery Syndrome	0.8%
840	Nelson Syndrome	0.8%
841	Prognathism	0.8%
842	Waterhouse-Friderichsen Syndrome	0.8%
843	Hand-Arm Vibration Syndrome	0.7%
844	Vision Disorders	0.7%
845	Metamorphopsia	0.7%
846	Visual Impairment	0.7%
847	Fibromyalgia	0.7%
848	Optic Neuropathy, Ischemic	0.7%
849	Anterior Ischemic Optic Neuropathy	0.7%
850	Medial Tibial Stress Syndrome	0.7%
851	Facial Hemiatrophy	0.7%
852	Melkersson-Rosenthal Syndrome	0.7%
853	Anisocoria	0.7%
854	Confusion	0.7%
855	Facial paralysis	0.7%
856	Lethargy	0.7%
857	Memory Disorders	0.7%
858	Muscle Cramp	0.7%
859	Perceptual Disorders	0.7%
860	Psychomotor Disorders	0.7%
861	Tonic Pupil	0.7%
862	Eosinophilia-Myalgia Syndrome	0.7%
863	Anhedonia	0.7%
864	Disorientation	0.7%
865	Facial Paresis	0.7%
866	Memory Loss	0.7%
867	Hemisensory Neglect	0.7%
868	Dysacusis	0.7%
869	Sleep Bruxism	0.7%
870	Muscular Atrophy	0.7%
871	Respiratory Paralysis	0.7%
872	Malaria, Cerebral	0.7%
873	Neurocysticercosis	0.7%
874	Tarsal Tunnel Syndrome	0.7%
875	Cauda Equina Syndrome	0.7%
876	Consciousness Disorders	0.7%
877	Mental Retardation	0.7%
878	Muscle Weakness	0.7%
879	Depressed Level of Consciousness	0.7%
880	Mental deficiency	0.7%
881	Intellectual Disability	0.7%
882	Bell Palsy	0.7%
883	Catatonia	0.7%
884	Herpes Zoster Oticus	0.7%
885	Aphonia	0.7%
886	Sleep Deprivation	0.7%
887	Dysphonia	0.7%
888	Carpal Tunnel Syndrome	0.6%
889	Aortopulmonary Septal Defect	0.6%
890	Double Outlet Right Ventricle	0.6%
891	Endocardial Cushion Defects	0.6%
892	neurofibroma	0.6%
893	Myocardial bridging	0.6%
894	Aorticopulmonary Septal Defect	0.6%
895	Sciatica	0.6%
896	Myalgia	0.6%
897	Mandibulofacial Dysostosis	0.6%
898	Romano-Ward Syndrome	0.6%
899	Hoarseness	0.6%
900	Alcohol Withdrawal Delirium	0.6%
901	Sciatic Neuropathy	0.5%
902	Ulnar Neuropathies	0.5%
903	Lesion of Sciatic Nerve	0.5%
904	Ulnar Neuritis	0.5%
905	Radial nerve compression	0.5%
906	Radial Tunnel Syndrome	0.5%
907	Peroneal Neuropathies	0.5%
908	Radial Neuropathy	0.5%
909	Median Neuropathy	0.5%
910	Sciatic Nerve Palsy	0.5%
911	Femoral Neuropathy	0.5%
912	Tibial Neuropathy	0.5%
913	Ulnar Nerve Palsy	0.5%
914	Postural Orthostatic Tachycardia Syndrome	0.5%
915	Radial nerve palsy	0.5%
916	Arteriovenous fistula	0.5%
917	Cubital Tunnel Syndrome	0.5%
918	Truncus Arteriosus, Persistent	0.5%
919	Goldenhar Syndrome	0.5%
920	Thoracic Outlet Syndrome	0.4%
921	Esotropia	0.4%
922	Exotropia	0.4%
923	Hypotension, Orthostatic	0.4%
924	Sleep Apnea Syndromes	0.4%
925	Polymyositis	0.4%
926	Post-Exercise Hypotension	0.4%
927	Disorders of Excessive Somnolence	0.4%
928	Sleep Initiation and Maintenance Disorders	0.4%
929	Night Terrors	0.4%
930	Somnambulism	0.4%
931	Trigeminal Nerve Disorder	0.4%
932	Transient Insomnia	0.4%
933	Sleep Paralysis	0.4%
934	Chronic Insomnia	0.4%
935	REM Sleep Behavior Disorder	0.4%
936	Hypersomnia	0.4%
937	Dysgeusia	0.4%
938	Formication	0.4%
939	Hyperalgesia	0.4%
940	Hyperesthesia	0.4%
941	Hypesthesia	0.4%
942	Language Disorders	0.4%
943	Numbness	0.4%
944	Paresthesia	0.4%
945	Paraparesis, Spastic	0.4%
946	Trismus	0.4%
947	Epilepsia Partialis Continua	0.4%
948	Hypogeusia	0.4%
949	Meningeal Carcinomatosis	0.4%
950	Brown-Sequard Syndrome	0.4%
951	Lockjaw	0.4%
952	Allodynia	0.4%
953	Lead Poisoning, Nervous System, Childhood	0.4%
954	Lead Poisoning, Nervous System, Adult	0.4%
955	Ageusia	0.4%
956	Talipes	0.4%
957	Eye Injuries	0.4%
958	Orbital Myositis	0.4%
959	Diplopia	0.4%
960	Muscle Rigidity	0.4%
961	Muscle Spasticity	0.4%
962	Scotoma	0.4%
963	Photophobia	0.4%
964	Cogwheel Rigidity	0.4%
965	Hemifacial Spasm	0.4%
966	Amaurosis	0.4%
967	Blindness	0.4%
968	Nuchal Rigidity	0.4%
969	Pyomyositis	0.4%
970	Agnosia	0.4%
971	Apraxias	0.4%
972	Hallucinations	0.4%
973	Hemianopsia	0.4%
974	Hyperacusis	0.4%
975	Tinnitus	0.4%
976	Visual Agnosia	0.4%
977	Anosognosia	0.4%
978	Wernicke-Korsakoff Syndrome	0.4%
979	Phonophobia	0.4%
980	Hearing Loss	0.4%
981	Sarcopenia	0.4%
982	Alexia	0.4%
983	Dyslexia	0.4%
984	Amnesia	0.4%
985	Delirium	0.4%
986	Dissociative Amnesia	0.4%
987	Color blindness	0.4%
988	Global Amnesia	0.4%
989	Meningioma	0.4%
990	Congenital clubfoot	0.4%
991	Vertical Talus	0.4%
992	Phantom pain	0.3%
993	Phantom Limb Pain	0.3%
994	Neurofibrosarcoma	0.3%
995	Polyradiculopathy	0.3%
996	Sleep Apnea, Obstructive	0.3%
997	Sleep Apnea, Central	0.3%
998	Narcolepsy	0.3%
999	Trigeminal Neuralgia	0.3%
1000	Kleine-Levin Syndrome	0.3%
1001	Agraphia	0.3%
1002	Anomia	0.3%
1003	Cluttering	0.3%
1004	Language Development Disorders	0.3%
1005	Speech Disorders	0.3%
1006	Syncope	0.3%
1007	Stupor	0.3%
1008	Dysgraphia	0.3%
1009	Presyncope	0.3%
1010	Dyslalia	0.3%
1011	Eye Burns	0.2%
1012	Amaurosis Fugax	0.2%
1013	Blindness, Cortical	0.2%
1014	Dyscalculia	0.2%
1015	Deafness	0.2%
1016	Hearing Loss, Sudden	0.2%
1017	Gerstmann Syndrome	0.2%
1018	Hearing Loss, Bilateral	0.2%
1019	Hearing Loss, High-Frequency	0.2%
1020	Hearing Loss, Mixed Conductive-Sensorineural	0.2%
1021	Prosopagnosia	0.2%
1022	Apraxia, Ideomotor	0.2%
1023	Charles Bonnet Syndrome	0.2%
1024	Hearing Loss, Unilateral	0.2%
1025	Complete Hearing Loss	0.2%
1026	Alien Hand Syndrome	0.2%
1027	Deaf Mutism	0.2%
1028	Dermatomyositis	0.2%
1029	Corneal Scar	0.2%
1030	Retrograde amnesia	0.2%
1031	Amnesia, Anterograde	0.2%
1032	Cataplexy	0.2%
1033	Aphasia	0.2%
1034	Articulation Disorders	0.2%
1035	Echolalia	0.2%
1036	Stuttering	0.2%
1037	Dysphasia	0.2%
1038	Mutism	0.2%
1039	Selective Mutism	0.2%
1040	Corneal Perforation	0.1%
1041	Dysarthria	0.1%
1042	Alexia, Pure	0.1%

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