MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Aniridia

(UMLS:C0003076)

Definition:: A congenital abnormality in which there is only a rudimentary iris. This is due to the failure of the optic cup to grow. Aniridia also occurs in a hereditary form, usually autosomal dominant.
UMLS ID:: C0003076
MeSH ID:: D015783

Classification 1:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.250.060|C11.270.060|C11.941.375.060

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.384.079|C16.320.290.078

Synonym(s)

Aniridia

ANIRIDIA 1

Absence of iris

Absent iris

Agenesis of iris

Aplasia of iris

Congenital absence of iris

Congenital aniridia

Irideremia

10.

absence; iris

11.

agenesis; iris

12.

anirida

13.

aniridia

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Latanoprost	FAERS: 2	US FAERS
2	Isotretinoin	FAERS: 1	US FAERS
3	Lamotrigine	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
4	Misoprostol	FAERS: 1	US FAERS
5	Thyroxine	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Retinal Dysplasia	55.9%
2	Blepharophimosis	39.7%
3	Aicardi's syndrome	37.8%
4	Retinitis Pigmentosa	35.3%
5	Pigmentary retinopathy	35.3%
6	Duane Retraction Syndrome	35.1%
7	Anophthalmos	34.3%
8	Microphthalmos	34.3%
9	Iridocorneal endothelial syndrome	30.4%
10	Retinal Degeneration	29.7%
11	CHARGE Syndrome	29.1%
12	Albinism	27.5%
13	Iridocyclitis	27.2%
14	Iritis	27.2%
15	Alstrom Syndrome	24.6%
16	Uveal Neoplasms	24.1%
17	Exfoliation Syndrome	22.7%
18	Pars Planitis	22.2%
19	Optic Atrophy, Hereditary, Leber	21.3%
20	Chorioretinitis	21%
21	Beckwith-Wiedemann Syndrome	20.3%
22	Wolf-Hirschhorn Syndrome	20.3%
23	Holoprosencephaly	20.1%
24	Asthenopia	20%
25	Conjunctival Diseases	20%
26	Corneal Diseases	20%
27	Eyelid Diseases	20%
28	Lacrimal Apparatus Diseases	20%
29	Lens Diseases	20%
30	Ocular Hypertension	20%
31	Ocular Hypotension	20%
32	Retinal Diseases	20%
33	Scleral Diseases	20%
34	Vitreous Detachment	20%
35	Posterior Vitreous Detachment	20%
36	Choroid Hemorrhage	19.6%
37	Choroid Diseases	19.5%
38	Uveitis	19.5%
39	Choroiditis	19.5%
40	Retinoblastoma	19.5%
41	Eyelid Neoplasms	18.9%
42	Retinal Hemorrhage	18.9%
43	Color blindness	18.8%
44	Xerophthalmia	18.6%
45	Low Tension Glaucoma	18.6%
46	Smith-Magenis syndrome	18.2%
47	Cri-du-Chat Syndrome	18%
48	Down Syndrome	18%
49	Trisomy 21	18%
50	Keratoconjunctivitis Sicca	17.6%
51	Eye Infection	17.2%
52	Eye Manifestations	17.2%
53	Eye Neoplasms	17.2%
54	Optic Neuropathy	17.2%
55	Rubinstein-Taybi Syndrome	16.7%
56	Kartagener Syndrome	16.6%
57	Corneal Scar	16.6%
58	Aniridia	16.4%
59	Corneal Ulcer	16.2%
60	Ectodermal Dysplasia	16.2%
61	Aplasia Cutis Congenita	16.2%
62	Prader-Willi Syndrome	16.1%
63	Fragile X Syndrome	15.9%
64	Keratoconjunctivitis	15.5%
65	Nail-Patella Syndrome	15.3%
66	Ichthyosis, X-Linked	15.2%
67	Ocular Motility Disorders	15%
68	Cyclophoria	15%
69	Pupil Disorders	14.9%
70	Eye Hemorrhage	14.8%
71	Marfan Syndrome	14.7%
72	Vision Disorders	14.7%
73	Metamorphopsia	14.7%
74	Visual Impairment	14.7%
75	Retinopathy of Prematurity	14.7%
76	Cockayne Syndrome	14.7%
77	Eye Injuries	14.7%
78	Trachoma	14.5%
79	Hordeolum	14.3%
80	Eye Abnormalities	14.1%
81	Mandibulofacial Dysostosis	14.1%
82	Cystic Fibrosis	14%
83	Abnormalities, Drug-Induced	13.8%
84	Situs Inversus	13.8%
85	Panuveitis	13.6%
86	Angioid Streaks	12.6%
87	Anisometropia	12.6%
88	Aphakia	12.6%
89	Astigmatism	12.6%
90	Blepharitis	12.6%
91	Blepharoptosis	12.6%
92	Blepharospasm	12.6%
93	Conjunctivitis	12.6%
94	Corneal edema	12.6%
95	Corneal Opacity	12.6%
96	Dacryocystitis	12.6%
97	Dry Eye Syndromes	12.6%
98	Ectropion	12.6%
99	Enophthalmos	12.6%
100	Entropion	12.6%
101	Episcleritis	12.6%
102	Exophthalmos	12.6%
103	Glaucoma	12.6%
104	Keratitis	12.6%
105	Keratoconus	12.6%
106	Lacrimal Duct Obstruction	12.6%
107	Lens dislocation	12.6%
108	Lens Subluxation	12.6%
109	Mydriasis	12.6%
110	Myopia	12.6%
111	Presbyopia	12.6%
112	Pterygium	12.6%
113	Retinal Detachment	12.6%
114	Retinitis	12.6%
115	Scleritis	12.6%
116	Corneal Neovascularization	12.6%
117	Orbital Pseudotumor	12.6%
118	Cataract	12.6%
119	Pinguecula	12.6%
120	Trichiasis	12.6%
121	Panophthalmitis	12.4%
122	Acanthamoeba Keratitis	12.1%
123	Neoplastic Syndromes, Hereditary	12.1%
124	Cardiovascular Abnormalities	12.1%
125	Smith-Lemli-Opitz Syndrome	12.1%
126	Keratitis, Herpetic	12.1%
127	Cytomegalovirus Retinitis	12.1%
128	Bacterial conjunctivitis	12%
129	Anemia, Sickle Cell	12%
130	Thalassemia	12%
131	Muscular Dystrophy, Duchenne	11.9%
132	Polycystic Kidney Diseases	11.9%
133	Williams Syndrome	11.9%
134	Congenital nystagmus	11.9%
135	Skin Abnormalities	11.9%
136	Lymphatic Abnormalities	11.9%
137	Congenital Microtia	11.9%
138	Corneal Perforation	11.9%
139	Anencephaly	11.8%
140	Multiple Epiphyseal Dysplasia	11.8%
141	Osteochondrodysplasias	11.8%
142	Pelger-Huet Anomaly	11.8%
143	Werner Syndrome	11.8%
144	Myasthenic Syndromes, Congenital	11.8%
145	Congenital diaphragmatic hernia	11.7%
146	Choroidal Neovascularization	11.6%
147	Ophthalmia Neonatorum	11.5%
148	Mucopolysaccharidosis II	11.1%
149	Primary Ciliary Dyskinesia	11%
150	Sjogren-Larsson Syndrome	10.9%
151	Epidermolysis Bullosa	10.8%
152	Endophthalmitis	10.8%
153	Optic Atrophy	10.8%
154	Optic Neuritis	10.8%
155	Papilledema	10.8%
156	Pemphigoid, Benign Mucous Membrane	10.8%
157	Retinal Artery Occlusion	10.8%
158	Strabismus	10.8%
159	Tolosa-Hunt Syndrome	10.8%
160	Orbital Cellulitis	10.8%
161	Retinal Vasculitis	10.8%
162	Hypertensive Retinopathy	10.8%
163	Retrobulbar Hemorrhage	10.8%
164	Corneal Endothelial Cell Loss	10.8%
165	Anterior uveitis	10.7%
166	Uveitis, Posterior	10.7%
167	Hyphema	10.7%
168	Retinal Neovascularization	10.7%
169	Vitreous Hemorrhage	10.7%
170	Urogenital Abnormalities	10.6%
171	Xeroderma	10.6%
172	Mobius Syndrome	10.6%
173	Maxillofacial Abnormalities	10.6%
174	Dural Arteriovenous Fistula	10.6%
175	Dwarfism	10.5%
176	Menkes Kinky Hair Syndrome	10.5%
177	Dextrocardia	10.5%
178	Kallmann Syndrome	10.3%
179	Uveomeningoencephalitic Syndrome	10.3%
180	Classical Lissencephalies and Subcortical Band Heterotopias	10.2%
181	Tuberous Sclerosis	10.2%
182	Muscular Dystrophy	10.2%
183	Osteogenesis Imperfecta	10.2%
184	Fetal Diseases	10.1%
185	Rett Syndrome	10%
186	Behcet Syndrome	10%
187	Refsum Disease	9.9%
188	Wiskott-Aldrich Syndrome	9.7%
189	Optic Neuropathy, Ischemic	9.5%
190	Anterior Ischemic Optic Neuropathy	9.5%
191	Turner Syndrome	9.5%
192	Retinal Vein Occlusion	9.4%
193	Anisocoria	9.4%
194	Diabetic Retinopathy	9.4%
195	Tonic Pupil	9.4%
196	Eye pain	9.4%
197	Orbital Myositis	9.4%
198	Diplopia	9.3%
199	Scotoma	9.3%
200	Photophobia	9.3%
201	Amaurosis	9.3%
202	Blindness	9.3%
203	Iris Diseases	9.2%
204	Autoimmune Lymphoproliferative Syndrome	9.2%
205	Angle Closure Glaucoma	9.1%
206	Glaucoma, Open-Angle	9.1%
207	Macular degeneration	9.1%
208	Familial Mediterranean Fever	9.1%
209	Prune Belly Syndrome	9.1%
210	Retinal Drusen	9.1%
211	Retinal Necrosis Syndrome, Acute	9.1%
212	Twins, Conjoined	9.1%
213	Retinoschisis	9.1%
214	Waardenburg Syndrome	9.1%
215	Pseudoxanthoma Elasticum	9%
216	Adrenoleukodystrophy	9%
217	Angioedemas, Hereditary	9%
218	Myotonic Dystrophy	8.9%
219	Sickle Cell Trait	8.9%
220	Zellweger Syndrome	8.9%
221	Polycystic Kidney, Autosomal Dominant	8.8%
222	Scimitar Syndrome	8.7%
223	Acrocephalosyndactylia	8.7%
224	Neuronal Ceroid-Lipofuscinoses	8.7%
225	Hyperkeratosis, Epidermolytic	8.4%
226	Xeroderma Pigmentosum	8.3%
227	Hepatolenticular Degeneration	8.3%
228	Ophthalmoplegia	8.3%
229	External Ophthalmoplegia	8.3%
230	Meconium Aspiration Syndrome	8.3%
231	Amblyopia	8.3%
232	Klinefelter Syndrome	8.2%
233	Fabry Disease	8.2%
234	Microcephaly	8.2%
235	Macrocephaly	8.2%
236	Abnormalities, Radiation-Induced	8.1%
237	Craniosynostosis	8%
238	Syndactyly	8%
239	Brachycephaly	8%
240	Charcot-Marie-Tooth Disease	8%
241	Antley-Bixler Syndrome Phenotype	8%
242	Anus, Imperforate	7.8%
243	Hydranencephaly	7.8%
244	Neural Tube Defects	7.8%
245	Tethered Cord Syndrome	7.8%
246	Iniencephaly	7.8%
247	Craniorachischisis	7.8%
248	Limb Deformities, Congenital	7.8%
249	Exencephaly	7.8%
250	Septo-Optic Dysplasia	7.8%
251	Craniofacial Abnormalities	7.8%
252	Cortical Dysplasia	7.8%
253	Malformations of Cortical Development	7.8%
254	Anorectal Malformations	7.8%
255	Amino Acid Metabolism, Inborn Errors	7.8%
256	Bloom Syndrome	7.8%
257	Carbohydrate Metabolism, Inborn Errors	7.8%
258	Metal Metabolism, Inborn Errors	7.8%
259	Progeria	7.8%
260	Lysosomal Storage Diseases	7.8%
261	Cytochrome-c Oxidase Deficiency	7.8%
262	Peroxisomal Disorders	7.8%
263	Amyloid Neuropathies, Familial	7.7%
264	Esotropia	7.7%
265	Exotropia	7.7%
266	Basal Cell Nevus Syndrome	7.6%
267	Glycogen storage disease type II	7.5%
268	Porencephaly	7.4%
269	Noonan Syndrome	7.4%
270	Acute Chest Syndrome	7.3%
271	Cleft Palate	7.3%
272	Galactosemias	7.2%
273	Urea Cycle Disorders, Inborn	7.2%
274	Tyrosinemias	7.2%
275	Abdominal Cramps	6.9%
276	Amniotic Band Syndrome	6.9%
277	Asphyxia Neonatorum	6.9%
278	Infant, Premature, Diseases	6.9%
279	Laryngostenosis	6.9%
280	Mouth Abnormalities	6.9%
281	Infantile Colic	6.9%
282	Cutis Laxa	6.8%
283	Esophageal Atresia	6.8%
284	Intestinal Atresia	6.8%
285	Horseshoe Kidney	6.8%
286	Pectus excavatum	6.8%
287	Klippel-Feil Syndrome	6.8%
288	Gastroschisis	6.8%
289	Synostosis	6.8%
290	Herpes Zoster Ophthalmicus	6.8%
291	Ataxia Telangiectasia	6.8%
292	Acrodermatitis	6.8%
293	Lymphangiectasis, Intestinal	6.8%
294	Porokeratosis	6.8%
295	Gianotti-Crosti Syndrome	6.8%
296	Keratoderma, Palmoplantar	6.8%
297	Jaw Abnormalities	6.8%
298	Chronic granulomatous disease	6.8%
299	Hemianopsia	6.7%
300	Welander Distal Myopathy	6.7%
301	Amaurosis Fugax	6.7%
302	Blindness, Cortical	6.7%
303	Poland Syndrome	6.6%
304	Canavan Disease	6.6%
305	Alexander Disease	6.6%
306	Hyperphosphaturia	6.6%
307	Mucopolysaccharidosis III	6.6%
308	Gaucher Disease	6.3%
309	Opsoclonus-Myoclonus Syndrome	6.2%
310	Arthrogryposis	6.2%
311	Choanal Atresia	6.2%
312	Tracheobronchomegaly	6.2%
313	Laryngocele	6.2%
314	Choledochal Cyst	6.1%
315	Hermaphroditism	6.1%
316	Disorders of Sex Development	6.1%
317	Homocystinuria	6.1%
318	Cryptorchidism	6.1%
319	Graves Disease	6.1%
320	Porphyrias, Hepatic	6.1%
321	Hypospadias	6.1%
322	Leigh Disease	6.1%
323	Central Nervous System Cysts	6%
324	Dandy-Walker Syndrome	6%
325	Horner Syndrome	6%
326	Peutz-Jeghers Syndrome	6%
327	Myotonia Congenita	6%
328	Thrombasthenia	6%
329	Antithrombin III Deficiency	6%
330	Protein C Deficiency	6%
331	Brain Diseases, Metabolic, Inborn	6%
332	Afibrinogenemia	6%
333	Dystonia Musculorum Deformans	6%
334	Factor VII Deficiency	6%
335	Factor X Deficiency	6%
336	Factor XII Deficiency	6%
337	Hemophilia A	6%
338	POEMS Syndrome	6%
339	Activated Protein C Resistance	6%
340	Factor II deficiency	6%
341	Factor VIII Deficiency	6%
342	Factor V deficiency	6%
343	Factor XI Deficiency	6%
344	Hypoprothrombinemias	6%
345	Fanconi Anemia	5.9%
346	Lafora Disease	5.9%
347	Unverricht-Lundborg Syndrome	5.9%
348	Anemia, Diamond-Blackfan	5.9%
349	Anemia, Neonatal	5.9%
350	Persistent Fetal Circulation Syndrome	5.9%
351	Deformity	5.9%
352	Genetic Diseases, Inborn	5.9%
353	Umbilical hernia	5.8%
354	Amelia	5.8%
355	Arachnodactyly	5.8%
356	Ectopia Cordis	5.8%
357	Ectromelia	5.8%
358	Hemimelia	5.8%
359	Meningomyelocele	5.8%
360	Phocomelia	5.8%
361	Sirenomelia	5.8%
362	Spina Bifida	5.8%
363	Polydactyly	5.8%
364	Brachydactyly	5.8%
365	Plagiocephaly	5.8%
366	Lower Extremity Deformities, Congenital	5.8%
367	Upper Extremity Deformities, Congenital	5.8%
368	Single umbilical artery	5.8%
369	Alkaptonuria	5.8%
370	Glycogen Storage Disease	5.8%
371	Hypophosphatasia	5.8%
372	Propionic acidemia	5.8%
373	Dihydropyrimidine Dehydrogenase Deficiency	5.8%
374	Cystinosis	5.8%
375	Micrognathism	5.7%
376	Pierre Robin Syndrome	5.7%
377	Tay-Sachs Disease	5.7%
378	Miller Fisher Syndrome	5.6%
379	Multiple Endocrine Neoplasia	5.5%
380	Laryngomalacia	5.5%
381	Niemann-Pick Disease, Type C	5.5%
382	Pectus carinatum	5.5%
383	Carbamoyl-Phosphate Synthase I Deficiency Disease	5.5%
384	Bladder Exstrophy	5.4%
385	Congenital Hypothyroidism	5.4%
386	Epispadias	5.4%
387	Dermatitis, Atopic	5.4%
388	Multicystic Dysplastic Kidney	5.4%
389	Kearns-Sayre syndrome	5.4%
390	Retrognathia	5.3%
391	Neonatal Abstinence Syndrome	5.2%
392	Fetal Growth Retardation	5.1%
393	Fetal Hypoxia	5.1%
394	Fetal Alcohol Spectrum Disorders	5.1%
395	Toxoplasmosis, Congenital	5.1%
396	Aortic coarctation	5.1%
397	Cor Triatriatum	5.1%
398	Coronary Vessel Anomalies	5.1%
399	Dental Enamel Hypoplasia	5.1%
400	Patent ductus arteriosus	5.1%
401	Ebstein Anomaly	5.1%
402	Heart Septal Defects	5.1%
403	Hypodontia	5.1%
404	Macrostomia	5.1%
405	Meningocele	5.1%
406	Microstomia	5.1%
407	Syphilis, Congenital	5.1%
408	Tetralogy of Fallot	5.1%
409	Transposition of Great Vessels	5.1%
410	Hypoplastic Left Heart Syndrome	5.1%
411	May-Thurner Syndrome	5.1%
412	Encephalocele	5.1%
413	Hyperandrogenism	5.1%
414	Craniofacial Dysostosis	5%
415	Hydrops Fetalis	5%
416	Hypolipoproteinemias	5%
417	Papillon-Lefevre Disease	5%
418	Wolff-Parkinson-White Syndrome	5%
419	Hyperlipidemia, Familial Combined	5%
420	Hyperlipoproteinemia Type III	5%
421	Sicca Syndrome	4.9%
422	Sjogren's Syndrome	4.9%
423	Prognathism	4.9%
424	Dermal Sinus	4.8%
425	Spina Bifida Cystica	4.8%
426	Spina Bifida Occulta	4.8%
427	Lissencephaly	4.8%
428	Polymicrogyria	4.8%
429	Pachygyria	4.8%
430	Schizencephaly	4.8%
431	Periventricular Nodular Heterotopia	4.8%
432	Glycogen Storage Disease Type I	4.8%
433	Glycogen Storage Disease Type V	4.8%
434	Congenital Hyperinsulinism	4.5%
435	Chorioamnionitis	4.5%
436	Familial Periodic Paralysis	4.5%
437	Long QT Syndrome	4.5%
438	Platybasia	4.5%
439	Tricuspid Atresia	4.5%
440	Arrhythmogenic Right Ventricular Dysplasia	4.5%
441	Ophthalmoplegic Migraine	4.5%
442	Gonadal Dysgenesis	4.5%
443	Bronchomalacia	4.5%
444	Adrenogenital Syndrome	4.5%
445	Tracheomalacia	4.5%
446	Ovotesticular Disorders of Sex Development	4.5%
447	Lactose Intolerance	4.5%
448	Variegate Porphyria	4.5%
449	Acute intermittent porphyria	4.5%
450	Porphyria Cutanea Tarda	4.5%
451	Huntington Disease	4.5%
452	Hyperhomocysteinemia	4.4%
453	Progressive supranuclear palsy	4.4%
454	Renal Aminoacidurias	4.4%
455	Fanconi Syndrome	4.4%
456	Pseudohypoaldosteronism	4.4%
457	Liddle Syndrome	4.4%
458	Hyperlipoproteinemia Type IV	4.4%
459	Hyperlipoproteinemia Type V	4.4%
460	Denys-Drash Syndrome	4.2%
461	Aortopulmonary Septal Defect	4.2%
462	Double Outlet Right Ventricle	4.2%
463	Endocardial Cushion Defects	4.2%
464	Myocardial bridging	4.2%
465	Aorticopulmonary Septal Defect	4.2%
466	Hypoalphalipoproteinemias	4.2%
467	Nephroblastoma	4.1%
468	Neuromyelitis Optica	4.1%
469	Gout	4.1%
470	Multiple Endocrine Neoplasia Type 1	4%
471	Pseudohypoparathyroidism	4%
472	Friedreich Ataxia	4%
473	Renal tubular acidosis	4%
474	Paralysis, Obstetric	3.9%
475	Bronchopulmonary Dysplasia	3.9%
476	Familial Hypophosphatemic Rickets	3.8%
477	Adenomatous Polyposis Coli	3.8%
478	Truncus Arteriosus, Persistent	3.7%
479	Goldenhar Syndrome	3.7%
480	Hypokalemic periodic paralysis	3.7%
481	Romano-Ward Syndrome	3.7%
482	Cystinuria	3.7%
483	Optic Nerve Glioma	3.5%
484	Respiratory Distress Syndrome, Newborn	3.4%
485	Talipes	3.3%
486	Arthritis, Gouty	3.3%
487	Glycosuria, Renal	3.3%
488	Congenital clubfoot	3.1%
489	Vertical Talus	3.1%
490	Arteriovenous fistula	3%
491	Leukomalacia, Periventricular	3%
492	Nesidioblastosis	3%
493	MELAS Syndrome	2.8%
494	Hyaline Membrane Disease	2.5%
495	Kernicterus	2.5%

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