MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leigh Disease

(UMLS:C0023264)

Definition:: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
UMLS ID:: C0023264
MeSH ID:: D007888

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.100.412

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.189.412|C16.320.565.202.810.444

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.100.412|C18.452.648.189.412|C18.452.648.202.810.444|C18.452.660.520

Synonym(s)

Leigh Disease

Infantile necrotizing encephalomyelopathy

LEIGH DISEASE

LEIGH SYNDROME

Leigh

Leigh Syndrome

Leigh disease

Leigh syndrome

Leigh's Disease

10.

Leigh's disease

11.

Leighs disease

12.

SNE

13.

SNEM - Subacute necrotising encephalomyelopathy

14.

SNEM - Subacute necrotizing encephalomyelopathy

15.

Subacute necrotising encephalomyelopathy

16.

Subacute necrotizing encephalomyelopathy

Associated Drug(s)

	Name	Reference(s)	Data Source
1	S-(2-carboxypropyl)cysteine	25125611	CTD
2	acryloyl-coenzyme A	25125611	CTD
3	methacrylyl-coenzyme A	25125611	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Galactosemias	65.5%
2	Urea Cycle Disorders, Inborn	59.5%
3	Tyrosinemias	59.5%
4	Adrenoleukodystrophy	56.4%
5	Carbamoyl-Phosphate Synthase I Deficiency Disease	53.2%
6	Homocystinuria	51.6%
7	Glycogen storage disease type II	51.5%
8	Hepatolenticular Degeneration	50.2%
9	Menkes Kinky Hair Syndrome	49.8%
10	Zellweger Syndrome	47%
11	Refsum Disease	46.5%
12	MELAS Syndrome	42.9%
13	Gaucher Disease	40.9%
14	Smith-Lemli-Opitz Syndrome	39.5%
15	Fabry Disease	38.5%
16	Pseudohypoparathyroidism	37.6%
17	Lactose Intolerance	36.9%
18	Amino Acid Metabolism, Inborn Errors	35.3%
19	Metal Metabolism, Inborn Errors	35.3%
20	Progeria	35.3%
21	Lysosomal Storage Diseases	35.3%
22	Peroxisomal Disorders	35.3%
23	Hyperphosphaturia	35.3%
24	Canavan Disease	34.4%
25	Alexander Disease	34.4%
26	Niemann-Pick Disease, Type C	34.2%
27	Tay-Sachs Disease	34%
28	Cytochrome-c Oxidase Deficiency	33.2%
29	Glycogen Storage Disease	31.5%
30	Hyperhomocysteinemia	31.4%
31	Wasting Syndrome	30%
32	Mitochondrial Encephalomyopathies	30%
33	Familial Hypophosphatemic Rickets	29.6%
34	Mucopolysaccharidosis III	29.4%
35	Hypolipoproteinemias	28.8%
36	Amyloid Neuropathies, Familial	28.5%
37	Hyperlipoproteinemia Type IV	28.3%
38	Hyperlipoproteinemia Type V	28.3%
39	Mucopolysaccharidosis II	28.2%
40	Hypercalcemia	27%
41	Hypocalcemia	27%
42	Milk-Alkali Syndrome	27%
43	Hyperlipidemia, Familial Combined	26.8%
44	Leigh Disease	26.2%
45	Hyperlipoproteinemia Type III	25.9%
46	Acid-Base Imbalance	25.1%
47	Calcium Metabolism Disorders	25.1%
48	Iron Metabolism Disorders	25.1%
49	Phosphorus Metabolism Disorders	25.1%
50	Water-Electrolyte Imbalance	25.1%
51	Lipid Metabolism Disorders	25.1%
52	Glucose Metabolism Disorders	25.1%
53	Brain Diseases, Metabolic, Inborn	25%
54	Myelinolysis, Central Pontine	25%
55	Neuronal Ceroid-Lipofuscinoses	24.6%
56	Lipodystrophy	24.4%
57	Renal tubular acidosis	24%
58	Werner Syndrome	24%
59	Rickets	23.7%
60	Reye Syndrome	23.3%
61	Hepatic Encephalopathy	23.3%
62	Alkaptonuria	22.9%
63	Hypophosphatasia	22.9%
64	Propionic acidemia	22.9%
65	Dihydropyrimidine Dehydrogenase Deficiency	22.9%
66	Cystinosis	22.9%
67	Carbohydrate Metabolism, Inborn Errors	22.7%
68	Albinism	22.6%
69	Osteopenia	22.5%
70	Glycogen Storage Disease Type I	22.5%
71	Glycogen Storage Disease Type V	22.5%
72	Ichthyosis, X-Linked	21.5%
73	Hypoalphalipoproteinemias	21.3%
74	Wernicke Encephalopathy	20.8%
75	Friedreich Ataxia	20.7%
76	Glycosuria, Renal	20.6%
77	Sjogren-Larsson Syndrome	19.8%
78	Familial Periodic Paralysis	19.7%
79	Cockayne Syndrome	19.7%
80	Kernicterus	19.5%
81	Renal Aminoacidurias	18.7%
82	Fanconi Syndrome	18.7%
83	Pseudohypoaldosteronism	18.7%
84	Liddle Syndrome	18.7%
85	Mitochondrial Myopathies	18.3%
86	Antley-Bixler Syndrome Phenotype	18.1%
87	Congenital Hyperinsulinism	18%
88	Ataxia Telangiectasia	18%
89	Optic Atrophy, Hereditary, Leber	17.8%
90	Mitochondrial Diseases	17.7%
91	Gout	17.4%
92	Brain Diseases, Metabolic	16.9%
93	Osteomalacia	16.4%
94	Kearns-Sayre syndrome	16.3%
95	Porphyrias, Hepatic	16.1%
96	Fanconi Anemia	15.9%
97	Bloom Syndrome	15.5%
98	Acidosis	15.2%
99	Alkalosis	15.2%
100	Amyloidosis	15.2%
101	Calcinosis	15.2%
102	Hyperglycemia	15.2%
103	Hyperinsulinism	15.2%
104	Hyperkalemia	15.2%
105	Hypernatremia	15.2%
106	Hypoglycemia	15.2%
107	Hypokalemia	15.2%
108	Hyponatremia	15.2%
109	Xanthomatosis	15.2%
110	Hypophosphatemia	15.2%
111	Metabolic acidosis	15.2%
112	Dyslipidemias	15.2%
113	Iron Overload	15.2%
114	Xanthoma	15.2%
115	Nutrition Disorders	15.1%
116	Diabetic Ketoacidosis	14.5%
117	Hypokalemic periodic paralysis	14.2%
118	Diabetes Mellitus	13.8%
119	Cystinuria	13.7%
120	Dehydration	13.6%
121	Lipomatosis	13.6%
122	Water Intoxication	13.6%
123	Achlorhydria	13.5%
124	Osteoporosis	13.5%
125	Bone Demineralization, Pathologic	13.5%
126	HIV Wasting Syndrome	13.5%
127	Post-Traumatic Osteoporosis	13.5%
128	Celiac Disease	13.5%
129	Sprue, Tropical	13.5%
130	Steatorrhea	13.5%
131	Sprue	13.5%
132	Nesidioblastosis	13.1%
133	Xeroderma Pigmentosum	13.1%
134	Renal Osteodystrophy	12.9%
135	Renal rickets	12.9%
136	HIV-Associated Lipodystrophy Syndrome	12.7%
137	Arthritis, Gouty	12.6%
138	Aicardi's syndrome	12.3%
139	Glycosuria	12.2%
140	Cystic Fibrosis	11.5%
141	Myasthenic Syndromes, Congenital	11.3%
142	CHARGE Syndrome	11.1%
143	Necrobiosis Lipoidica Diabeticorum	11.1%
144	Amyotrophic Lateral Sclerosis	11%
145	Neoplastic Syndromes, Hereditary	10.6%
146	Variegate Porphyria	10.6%
147	Acute intermittent porphyria	10.6%
148	Porphyria Cutanea Tarda	10.6%
149	Multiple Epiphyseal Dysplasia	10.3%
150	Osteochondrodysplasias	10.3%
151	Pelger-Huet Anomaly	10.3%
152	Acidosis, Lactic	10.3%
153	Calciphylaxis	10.3%
154	Hemosiderosis	10.3%
155	Ketosis	10.3%
156	Ketonuria	10.3%
157	Ketoacidosis	10.3%
158	Ketonemia	10.3%
159	Vascular calcification	10.3%
160	Nail-Patella Syndrome	10.2%
161	Prader-Willi Syndrome	10.1%
162	Alstrom Syndrome	10%
163	Dystonia Musculorum Deformans	10%
164	Muscular Dystrophy, Duchenne	10%
165	Huntington Disease	10%
166	Cerebral Amyloid Angiopathy	9.9%
167	Muscular Dystrophy	9.8%
168	Marchiafava-Bignami Disease	9.8%
169	Anemia, Sickle Cell	9.7%
170	Thalassemia	9.7%
171	Fragile X Syndrome	9.7%
172	Smith-Magenis syndrome	9.5%
173	Dwarfism	9.5%
174	Osteogenesis Imperfecta	9.3%
175	Kartagener Syndrome	9.2%
176	Dandy-Walker Syndrome	9.2%
177	Acidosis, Respiratory	9.2%
178	Adiposis Dolorosa	9.2%
179	Alkalosis, Respiratory	9.2%
180	Tuberous Sclerosis	9.1%
181	Insulin Resistance	9.1%
182	Osteoporosis, Postmenopausal	9.1%
183	Tetany	9%
184	Beckwith-Wiedemann Syndrome	8.9%
185	Wolf-Hirschhorn Syndrome	8.9%
186	Meningoencephalitis	8.8%
187	Marfan Syndrome	8.8%
188	Myotonic Dystrophy	8.8%
189	Holoprosencephaly	8.6%
190	Cri-du-Chat Syndrome	8.6%
191	Down Syndrome	8.6%
192	Trisomy 21	8.6%
193	Autoimmune Lymphoproliferative Syndrome	8.5%
194	Dementia, Vascular	8.4%
195	Angioedemas, Hereditary	8.4%
196	Gestational Diabetes	8.4%
197	Latent Autoimmune Diabetes in Adults	8.4%
198	Child Nutrition Disorders	8.4%
199	Hypervitaminosis A	8.4%
200	Infant Nutrition Disorders	8.4%
201	Malnutrition	8.4%
202	Diabetes Mellitus, Experimental	8.3%
203	Wiskott-Aldrich Syndrome	8.3%
204	Nephrocalcinosis	8.2%
205	Frontotemporal dementia	8.2%
206	Lafora Disease	8.1%
207	Unverricht-Lundborg Syndrome	8.1%
208	Subdural Effusion	7.9%
209	Hypercholesterolemia	7.8%
210	Hyperlipoproteinemias	7.8%
211	Hypertriglyceridemia	7.8%
212	Leukomalacia, Periventricular	7.8%
213	Kallmann Syndrome	7.7%
214	Encephalomyelitis	7.6%
215	Rubinstein-Taybi Syndrome	7.5%
216	Pneumocephalus	7.5%
217	Primary amyloidosis	7.5%
218	Ectodermal Dysplasia	7.5%
219	Aplasia Cutis Congenita	7.5%
220	Brain Abscess	7.4%
221	Multiple System Atrophy	7.4%
222	Deformity	7.2%
223	Lewy Body Disease	7.2%
224	Rett Syndrome	7.1%
225	Akinetic Mutism	7.1%
226	Anoxic Encephalopathy	7.1%
227	Basal Ganglia Diseases	7.1%
228	Brain Damage, Chronic	7.1%
229	Cerebellar Diseases	7.1%
230	Encephalitis	7.1%
231	Encephalomalacia	7.1%
232	Epilepsy	7.1%
233	Hydrocephalus	7.1%
234	Congenital Hydrocephalus	7.1%
235	Hypothalamic Diseases	7.1%
236	Thalamic Diseases	7.1%
237	Intracranial Hypertension	7.1%
238	Aura	7.1%
239	Leukoencephalopathy	7.1%
240	Neuroaxonal Dystrophies	7.1%
241	Headache Disorders	7.1%
242	Intracranial Hypotension	7.1%
243	Brain Edema	7.1%
244	Brain Hypoxia	7.1%
245	Aqueductal Stenosis	7.1%
246	Williams Syndrome	6.9%
247	Basal Ganglia Cerebrovascular Disease	6.8%
248	Familial Mediterranean Fever	6.7%
249	Epilepsy, Post-Traumatic	6.6%
250	Brain Injuries	6.5%
251	Fetal Diseases	6.5%
252	Brain Neoplasms	6.5%
253	Polycystic Kidney Diseases	6.5%
254	Parkinsonian Disorders	6.5%
255	Cerebrovascular Disorders	6.4%
256	Cerebrovascular Insufficiency	6.4%
257	Dementia	6.4%
258	CREST Syndrome	6.3%
259	Posterior Leukoencephalopathy Syndrome	6.2%
260	Posterior reversible encephalopathy syndrome	6.2%
261	Sickle Cell Trait	6.1%
262	Primary Ciliary Dyskinesia	6.1%
263	Retinal Dysplasia	6.1%
264	Myotonia Congenita	6.1%
265	Aniridia	6.1%
266	Ocular Motility Disorders	6.1%
267	Cyclophoria	6.1%
268	Epidermolysis Bullosa	6%
269	Brain Death	5.9%
270	Subacute Combined Degeneration	5.9%
271	Epidural Abscess	5.7%
272	Duane Retraction Syndrome	5.7%
273	Vascular Headaches	5.6%
274	Welander Distal Myopathy	5.6%
275	Hypoxia-Ischemia, Brain	5.6%
276	Amblyopia	5.6%
277	Meningitis	5.5%
278	Movement Disorders	5.5%
279	Pachymeningitis	5.5%
280	Spinal Cord Diseases	5.5%
281	Progressive supranuclear palsy	5.4%
282	Myelitis	5.4%
283	Cutis Laxa	5.4%
284	Cerebellar Neoplasms	5.4%
285	Leukoencephalopathy, Progressive Multifocal	5.4%
286	Retinitis Pigmentosa	5.4%
287	Pigmentary retinopathy	5.4%
288	Meige Syndrome	5.4%
289	Cerebral Ventriculitis	5.4%
290	Porokeratosis	5.4%
291	Keratoderma, Palmoplantar	5.4%
292	Chronic granulomatous disease	5.3%
293	Acute Chest Syndrome	5.3%
294	Meconium Aspiration Syndrome	5.3%
295	Mobius Syndrome	5.2%
296	Parkinson Disease	5.2%
297	Pseudoxanthoma Elasticum	5.2%
298	Lupus Vasculitis, Central Nervous System	5.1%
299	Charcot-Marie-Tooth Disease	5.1%
300	Deficiency Diseases	5.1%
301	Starvation	5.1%
302	Refeeding Syndrome	5.1%
303	Central Nervous System Infection	5%
304	Myoclonic Epilepsy	5%
305	Epilepsy, Temporal Lobe	5%
306	Epilepsy, Rolandic	5%
307	Benign Rolandic Epilepsy	5%
308	Amnesia, Transient Global	5%
309	Stiff-Person Syndrome	4.9%
310	Neuroleptic Malignant Syndrome	4.9%
311	Peutz-Jeghers Syndrome	4.9%
312	Thrombasthenia	4.9%
313	Antithrombin III Deficiency	4.9%
314	Protein C Deficiency	4.9%
315	Afibrinogenemia	4.9%
316	Factor VII Deficiency	4.9%
317	Factor X Deficiency	4.9%
318	Factor XII Deficiency	4.9%
319	Hemophilia A	4.9%
320	Activated Protein C Resistance	4.9%
321	Factor II deficiency	4.9%
322	Factor VIII Deficiency	4.9%
323	Factor V deficiency	4.9%
324	Factor XI Deficiency	4.9%
325	Hypoprothrombinemias	4.9%
326	Creutzfeldt-Jakob disease	4.8%
327	Anemia, Diamond-Blackfan	4.8%
328	Basal Ganglia Hemorrhage	4.7%
329	Limbic Encephalitis	4.7%
330	Classical Lissencephalies and Subcortical Band Heterotopias	4.7%
331	Multiple Endocrine Neoplasia	4.6%
332	Striatonigral Degeneration	4.5%
333	Congenital Hypothyroidism	4.5%
334	Dermatitis, Atopic	4.5%
335	Basal Cell Nevus Syndrome	4.5%
336	Xeroderma	4.5%
337	Prion Diseases	4.4%
338	Leukoencephalitis, Acute Hemorrhagic	4.4%
339	Pituitary Adenoma	4.3%
340	Pituitary Neoplasms	4.3%
341	Brain Hemorrhage, Traumatic	4.3%
342	Cerebral Palsy	4.2%
343	Epilepsies, Partial	4.2%
344	Epilepsy, Generalized	4.2%
345	Pseudotumor Cerebri	4.2%
346	Hypertensive Encephalopathy	4.2%
347	Simple Partial Seizures	4.2%
348	Epilepsy, Reflex	4.2%
349	Headache Disorders, Primary	4.2%
350	Headache Disorders, Secondary	4.2%
351	Medication overuse headache	4.2%
352	Presenile dementia	4.2%
353	Senile dementia	4.2%
354	Shy-Drager Syndrome	4.2%
355	Toxoplasmosis, Cerebral	4.2%
356	Behcet Syndrome	4.1%
357	Pituitary Apoplexy	4.1%
358	Carotid Artery Injuries	4.1%
359	Vasculitis, Central Nervous System	4.1%
360	Brain Infarction	4.1%
361	Polycystic Kidney, Autosomal Dominant	4.1%
362	Hyperkeratosis, Epidermolytic	4.1%
363	Spinal Muscular Atrophy	4.1%
364	Progressive Muscular Atrophy	4.1%
365	Toxoplasmosis, Congenital	4.1%
366	Ophthalmoplegic Migraine	4%
367	Dural Arteriovenous Fistula	4%
368	Spinal Cord Injuries	4%
369	Poliomyelitis	4%
370	Miller Fisher Syndrome	3.9%
371	Asterixis	3.9%
372	Ballismus	3.9%
373	Meningitis, Bacterial	3.9%
374	Meningitis, Fungal	3.9%
375	Abdominal Cramps	3.9%
376	Abnormalities, Drug-Induced	3.9%
377	Amniotic Band Syndrome	3.9%
378	Asphyxia Neonatorum	3.9%
379	Infant, Premature, Diseases	3.9%
380	Situs Inversus	3.9%
381	Infantile Colic	3.9%
382	Brain Injuries, Diffuse	3.9%
383	Traumatic Brain Injury	3.9%
384	Cerebellar Ataxia	3.9%
385	Supratentorial Neoplasms	3.9%
386	Pituitary Diseases	3.9%
387	Paraneoplastic Cerebellar Degeneration	3.8%
388	Carotid Artery Diseases	3.8%
389	Brain Ischemia	3.8%
390	Cerebrovascular accident	3.8%
391	Kluver-Bucy Syndrome	3.8%
392	Vasospasm, Intracranial	3.8%
393	Intracranial Arterial Diseases	3.8%
394	MPTP Poisoning	3.8%
395	Juvenile Myoclonic Epilepsy	3.7%
396	Myoclonic Epilepsies, Progressive	3.7%
397	Anencephaly	3.7%
398	Central Nervous System Cysts	3.7%
399	Persistent Vegetative State	3.7%
400	Chronic Fatigue Syndrome	3.7%
401	Obesity	3.7%
402	Putaminal Hemorrhage	3.6%
403	Hydranencephaly	3.6%
404	Neural Tube Defects	3.6%
405	Tethered Cord Syndrome	3.6%
406	Iniencephaly	3.6%
407	Craniorachischisis	3.6%
408	Exencephaly	3.6%
409	Septo-Optic Dysplasia	3.6%
410	Cortical Dysplasia	3.6%
411	Malformations of Cortical Development	3.6%
412	Congenital nystagmus	3.6%
413	Myelitis, Transverse	3.6%
414	Nephroblastoma	3.6%
415	Encephalomyelitis, Acute Disseminated	3.5%
416	Eye Abnormalities	3.5%
417	Cardiovascular Abnormalities	3.5%
418	Cranial nerve diseases	3.5%
419	Demyelinating Diseases	3.5%
420	Demyelination	3.5%
421	Neuromuscular Diseases	3.5%
422	Chronobiology Disorders	3.5%
423	Skin Abnormalities	3.5%
424	Lymphatic Abnormalities	3.5%
425	Congenital Microtia	3.5%
426	Anemia, Neonatal	3.4%
427	Persistent Fetal Circulation Syndrome	3.4%
428	Restless Legs Syndrome	3.4%
429	Congenital diaphragmatic hernia	3.4%
430	Infarction, Middle Cerebral Artery	3.4%
431	Infarction, Anterior Cerebral Artery	3.4%
432	Infarction, Posterior Cerebral Artery	3.4%
433	Umbilical hernia	3.4%
434	Kwashiorkor	3.4%
435	Magnesium Deficiency	3.4%
436	Potassium Deficiency	3.4%
437	Protein Deficiency	3.4%
438	Avitaminosis	3.4%
439	Intracranial Embolism and Thrombosis	3.4%
440	Papillon-Lefevre Disease	3.4%
441	Adenomatous Polyposis Coli	3.3%
442	Motor Neuron Disease	3.3%
443	Akathisia, Drug-Induced	3.3%
444	Moyamoya Disease	3.3%
445	Opsoclonus-Myoclonus Syndrome	3.3%
446	Spinal Cord Neoplasms	3.2%
447	Trauma, Nervous System	3.2%
448	Urogenital Abnormalities	3.2%
449	Nervous System Neoplasms	3.2%
450	Neurologic Manifestations	3.2%
451	Neurotoxicity Syndromes	3.2%
452	Neonatal Abstinence Syndrome	3.2%
453	Polyradiculoneuropathy	3.1%
454	Polyradiculoneuritis	3.1%
455	Fetal Growth Retardation	3.1%
456	Fetal Hypoxia	3.1%
457	Fetal Alcohol Spectrum Disorders	3.1%
458	Syphilis, Congenital	3.1%
459	Cerebral Infarction	3.1%
460	Brain Stem Infarctions	3.1%
461	Arachnoiditis	3%
462	Aseptic Meningitis	3%
463	Syringomyelia	3%
464	Essential Tremor	3%
465	Familial Tremor	3%
466	Pneumorrhachis	3%
467	Writer's Cramp	3%
468	Hydrops Fetalis	3%
469	Auditory Perceptual Disorders	3%
470	Turner Syndrome	3%
471	Dyskinesia, Drug-Induced	2.9%
472	Sleep Wake Disorders	2.9%
473	Klinefelter Syndrome	2.9%
474	Multiple Endocrine Neoplasia Type 1	2.8%
475	AIDS Dementia Complex	2.8%
476	Chorioamnionitis	2.8%
477	Post-Traumatic Headache	2.8%
478	Tension Headache	2.8%
479	Epilepsy, Complex Partial	2.8%
480	Migraine Disorders	2.8%
481	Abdominal Migraine	2.8%
482	Status Migrainosus	2.8%
483	Cervicogenic Headache	2.8%
484	Tuberculosis, Meningeal	2.8%
485	Subarachnoid Hemorrhage, Traumatic	2.7%
486	Carotid Artery, Internal, Dissection	2.7%
487	Central Nervous System Fungal Infections	2.7%
488	Conus Medullaris Syndrome	2.7%
489	Spinal Cord Vascular Diseases	2.7%
490	Obesity, Abdominal	2.7%
491	Maxillofacial Abnormalities	2.7%
492	Dextrocardia	2.7%
493	Subacute Sclerosing Panencephalitis	2.6%
494	Ascorbic Acid Deficiency	2.6%
495	Vitamin A Deficiency	2.6%
496	Vitamin D Deficiency	2.6%
497	Vitamin E Deficiency	2.6%
498	Marasmus	2.6%
499	Abnormalities, Radiation-Induced	2.6%
500	Diffuse Axonal Injury	2.6%
501	Brain Stem Neoplasms	2.6%
502	Vertebral Artery Dissection	2.6%
503	Autonomic Dysreflexia	2.5%
504	Complex Regional Pain Syndromes	2.5%
505	Lateral Medullary Syndrome	2.5%
506	Empty Sella Syndrome	2.5%
507	Hyperpituitarism	2.5%
508	Hypopituitarism	2.5%
509	Hypophysitis	2.5%
510	Cerebral Arterial Diseases	2.5%
511	Vertebrobasilar Insufficiency	2.5%
512	Basilar Artery Stenosis	2.5%
513	Vertebral Artery Stenosis	2.5%
514	Intracranial Hemorrhage, Hypertensive	2.5%
515	Transient Cerebral Ischemia	2.5%
516	Pediatric Obesity	2.5%
517	Central Nervous System Bacterial Infections	2.5%
518	Lambert-Eaton Myasthenic Syndrome	2.4%
519	Ophthalmia Neonatorum	2.4%
520	Brain Concussion	2.4%
521	Brain Contusion	2.3%
522	Peripheral Nerve Injuries	2.3%
523	Guillain-Barre Syndrome	2.3%
524	Scimitar Syndrome	2.3%
525	Myasthenia Gravis	2.3%
526	Scrapie	2.3%
527	Central Cord Syndrome	2.3%
528	Chorea	2.3%
529	Carotid Stenosis	2.3%
530	Intracranial Aneurysm	2.3%
531	Intracranial Arteriosclerosis	2.3%
532	Cerebral Atherosclerosis	2.3%
533	Subarachnoid Hemorrhage	2.3%
534	Cerebral Arteriosclerosis	2.3%
535	Cerebral Hemorrhage	2.3%
536	Cerebral Thrombosis	2.2%
537	Intracranial Embolism	2.2%
538	Intracranial Thrombosis	2.2%
539	Prune Belly Syndrome	2.2%
540	Twins, Conjoined	2.2%
541	Waardenburg Syndrome	2.2%
542	Folic Acid Deficiency	2.2%
543	Pellagra	2.2%
544	Thiamine Deficiency	2.2%
545	Vitamin B 12 Deficiency	2.2%
546	Vitamin B 6 Deficiency	2.2%
547	Pyridoxine Deficiency	2.2%
548	Microcephaly	2.2%
549	Meningitis, Cryptococcal	2.2%
550	Macrocephaly	2.2%
551	Giant Cell Arteritis	2.2%
552	Temporal Arteritis	2.2%
553	Denys-Drash Syndrome	2.2%
554	Meningitis, Listeria	2.2%
555	Meningitis, Haemophilus	2.2%
556	Meningitis, Pneumococcal	2.2%
557	Meningomyelocele	2.2%
558	Spina Bifida	2.2%
559	Sleep Disorders, Circadian Rhythm	2.1%
560	Cluster Headache	2.1%
561	Migraine with Aura	2.1%
562	Familial Hemiplegic Migraine	2.1%
563	Chronic Paroxysmal Hemicrania	2.1%
564	SUNCT Syndrome	2.1%
565	Paroxysmal Hemicrania	2.1%
566	Vitamin K Deficiency	2.1%
567	Botulism	2.1%
568	POEMS Syndrome	2.1%
569	Neuromyelitis Optica	2.1%
570	Carotid Artery Thrombosis	2%
571	Alice in Wonderland Syndrome	2%
572	Beriberi	2%
573	Anophthalmos	2%
574	Anus, Imperforate	2%
575	Microphthalmos	2%
576	Paralysis, Obstetric	2%
577	Retinopathy of Prematurity	2%
578	Limb Deformities, Congenital	2%
579	Craniofacial Abnormalities	2%
580	Anorectal Malformations	2%
581	Bronchopulmonary Dysplasia	2%
582	Meningocele	1.9%
583	Encephalocele	1.9%
584	Torticollis	1.9%
585	Choroid Plexus Papilloma	1.9%
586	Olfactory Nerve Injuries	1.9%
587	West Nile Fever	1.9%
588	Porencephaly	1.9%
589	Craniosynostosis	1.9%
590	Syndactyly	1.9%
591	Brachycephaly	1.9%
592	Acrocephalosyndactylia	1.9%
593	Hyperprolactinemia	1.9%
594	Subclavian Steal Syndrome	1.9%
595	Pick Disease of the Brain	1.9%
596	Dysautonomia	1.8%
597	Vagus Nerve Disorder	1.8%
598	Glossopharyngeal Neuralgia	1.8%
599	Abducens Nerve Diseases	1.8%
600	Heavy Metal Poisoning, Nervous System	1.8%
601	Neuromuscular Junction Diseases	1.8%
602	Tauopathies	1.8%
603	Trochlear Nerve Diseases	1.8%
604	Peripheral Nervous System Diseases	1.8%
605	Blepharophimosis	1.8%
606	Laryngostenosis	1.8%
607	Mouth Abnormalities	1.8%
608	Respiratory Distress Syndrome, Newborn	1.8%
609	Progressive bulbar palsy	1.8%
610	Bulbar palsy	1.8%
611	Esophageal Atresia	1.8%
612	Intestinal Atresia	1.8%
613	Horseshoe Kidney	1.8%
614	Pectus excavatum	1.8%
615	Klippel-Feil Syndrome	1.8%
616	Gastroschisis	1.8%
617	Synostosis	1.8%
618	Acrodermatitis	1.8%
619	Lymphangiectasis, Intestinal	1.8%
620	Gianotti-Crosti Syndrome	1.8%
621	Anemia, Pernicious	1.8%
622	Causalgia	1.8%
623	Horner Syndrome	1.8%
624	Scurvy	1.8%
625	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.8%
626	Noonan Syndrome	1.8%
627	Facial Nerve Injuries	1.8%
628	Acromegaly	1.7%
629	Sinus Thrombosis, Intracranial	1.7%
630	Myopathy	1.7%
631	Optic Neuropathy	1.7%
632	Hematoma, Subdural	1.7%
633	Hematoma, Epidural, Cranial	1.7%
634	Arthrogryposis	1.7%
635	Choanal Atresia	1.7%
636	Tracheobronchomegaly	1.7%
637	Laryngocele	1.7%
638	Choledochal Cyst	1.6%
639	Hermaphroditism	1.6%
640	Disorders of Sex Development	1.6%
641	Facial Nerve Diseases	1.6%
642	Craniocerebral Trauma	1.6%
643	Parasomnia	1.6%
644	Dyssomnias	1.6%
645	Cryptorchidism	1.6%
646	Hypospadias	1.6%
647	Vestibulocochlear Nerve Diseases	1.6%
648	Decerebrate State	1.6%
649	Hemiparesis	1.6%
650	Meningism	1.6%
651	Paresis	1.6%
652	Seizures	1.6%
653	Sensation Disorders	1.6%
654	Central Nervous System Neoplasms	1.6%
655	Complex partial seizures	1.6%
656	Monoparesis	1.6%
657	Neurogenic Inflammation	1.6%
658	Gait Disorders, Neurologic	1.6%
659	Neuromuscular Manifestations	1.6%
660	Jet Lag Syndrome	1.6%
661	Sweating, Gustatory	1.6%
662	Auriculotemporal Syndrome	1.6%
663	Multiple Sclerosis	1.6%
664	Myasthenia Gravis, Autoimmune, Experimental	1.6%
665	Cleft Palate	1.6%
666	Spinal Cord Ischemia	1.6%
667	Tuberculosis, Central Nervous System	1.6%
668	Laryngomalacia	1.5%
669	Pectus carinatum	1.5%
670	Jaw Abnormalities	1.5%
671	Pupil Disorders	1.5%
672	Neurobehavioral Manifestations	1.5%
673	Bladder Exstrophy	1.5%
674	Epispadias	1.5%
675	Multicystic Dysplastic Kidney	1.5%
676	Ophthalmoplegia	1.5%
677	External Ophthalmoplegia	1.5%
678	Paraneoplastic Encephalomyelitis	1.5%
679	Uveomeningoencephalitic Syndrome	1.5%
680	Sturge-Weber Syndrome	1.5%
681	Vertigo	1.5%
682	Alcohol-Induced Disorders, Nervous System	1.5%
683	Neuroaspergillosis	1.5%
684	Tardive Dyskinesia	1.4%
685	Reflex Sympathetic Dystrophy	1.4%
686	Nocturnal Myoclonus Syndrome	1.4%
687	Dermal Sinus	1.4%
688	Spina Bifida Cystica	1.4%
689	Spina Bifida Occulta	1.4%
690	Lissencephaly	1.4%
691	Polymicrogyria	1.4%
692	Pachygyria	1.4%
693	Schizencephaly	1.4%
694	Periventricular Nodular Heterotopia	1.4%
695	Prolactinoma	1.4%
696	Growth Hormone-Secreting Pituitary Adenoma	1.4%
697	Cavernous Sinus Thrombosis	1.4%
698	Sagittal Sinus Thrombosis	1.4%
699	Vocal Cord Paralysis	1.4%
700	Pseudorabies	1.4%
701	Voice Disorders	1.4%
702	Voice Disturbance	1.4%
703	Poland Syndrome	1.3%
704	Hematoma, Subdural, Intracranial	1.3%
705	Hematoma, Subdural, Chronic	1.3%
706	Hematoma, Subdural, Acute	1.3%
707	Neurosyphilis	1.3%
708	Acrodynia	1.3%
709	Nelson Syndrome	1.3%
710	Amelia	1.3%
711	Arachnodactyly	1.3%
712	Ectopia Cordis	1.3%
713	Ectromelia	1.3%
714	Hemimelia	1.3%
715	Phocomelia	1.3%
716	Sirenomelia	1.3%
717	Polydactyly	1.3%
718	Brachydactyly	1.3%
719	Plagiocephaly	1.3%
720	Lower Extremity Deformities, Congenital	1.3%
721	Upper Extremity Deformities, Congenital	1.3%
722	Single umbilical artery	1.3%
723	Alcohol Withdrawal Seizures	1.2%
724	Reflex, Abnormal	1.2%
725	Hyporeflexia	1.2%
726	Hyperreflexia	1.2%
727	Lyme Neuroborreliosis	1.2%
728	Cerebrospinal Fluid Otorrhea	1.2%
729	Cerebrospinal Fluid Rhinorrhea	1.2%
730	Neuritis, Autoimmune, Experimental	1.2%
731	Gait Ataxia	1.2%
732	Aortic coarctation	1.1%
733	Cor Triatriatum	1.1%
734	Coronary Vessel Anomalies	1.1%
735	Dental Enamel Hypoplasia	1.1%
736	Patent ductus arteriosus	1.1%
737	Ebstein Anomaly	1.1%
738	Heart Septal Defects	1.1%
739	Hyaline Membrane Disease	1.1%
740	Hypodontia	1.1%
741	Macrostomia	1.1%
742	Microstomia	1.1%
743	Tetralogy of Fallot	1.1%
744	Transposition of Great Vessels	1.1%
745	Hypoplastic Left Heart Syndrome	1.1%
746	May-Thurner Syndrome	1.1%
747	Craniofacial Dysostosis	1.1%
748	Wolff-Parkinson-White Syndrome	1.1%
749	Micrognathism	1.1%
750	Pierre Robin Syndrome	1.1%
751	Akathisia	1.1%
752	Restlessness	1.1%
753	Psychomotor Agitation	1.1%
754	Brachial Plexus Neuritis	1.1%
755	Neuralgic Amyotrophy	1.1%
756	Anterior Spinal Artery Syndrome	1.1%
757	Hyperandrogenism	1.1%
758	Waterhouse-Friderichsen Syndrome	1.1%
759	Coma, Post-Head Injury	1.1%
760	Retrognathia	1%
761	Optic Nerve Glioma	1%
762	Long QT Syndrome	1%
763	Platybasia	1%
764	Tricuspid Atresia	1%
765	Arrhythmogenic Right Ventricular Dysplasia	1%
766	Gonadal Dysgenesis	1%
767	Bronchomalacia	1%
768	Adrenogenital Syndrome	1%
769	Tracheomalacia	1%
770	Ovotesticular Disorders of Sex Development	1%
771	Acoustic Neuroma	1%
772	Neuritis	1%
773	Polyneuritis	1%
774	Radiculitis	1%
775	Polyneuropathy	1%
776	Mononeuritis	1%
777	Mononeuropathies	1%
778	Brachial Plexus Neuropathies	1%
779	Radiculopathy	1%
780	Mononeuropathy Multiplex	1%
781	Nerve Root Compression	1%
782	Prognathism	1%
783	Malaria, Cerebral	1%
784	Neurocysticercosis	1%
785	Multiple Sclerosis, Chronic Progressive	1%
786	Multiple Sclerosis, Relapsing-Remitting	1%
787	Gait Apraxia	0.9%
788	Myositis	0.9%
789	Optic Atrophy	0.9%
790	Optic Neuritis	0.9%
791	Papilledema	0.9%
792	Strabismus	0.9%
793	Tolosa-Hunt Syndrome	0.9%
794	Isaacs syndrome	0.9%
795	Arsenic Poisoning	0.9%
796	Myotonic Disorders	0.9%
797	Diabetic Neuropathies	0.9%
798	Facial Injuries	0.9%
799	Facial Neuralgia	0.9%
800	Diabetic Amyotrophy	0.9%
801	Diabetic Autonomic Neuropathy	0.9%
802	Sleep Talking	0.9%
803	Manganese Poisoning	0.9%
804	Sleep Disorders, Intrinsic	0.9%
805	Orthostatic intolerance	0.9%
806	Anosmia	0.9%
807	Ataxia	0.9%
808	Athetosis	0.9%
809	Catalepsy	0.9%
810	Dystonia	0.9%
811	Hemiplegia	0.9%
812	Locked-In Syndrome	0.9%
813	Meningeal Neoplasms	0.9%
814	Muscle Hypertonia	0.9%
815	Muscle hypotonia	0.9%
816	Myoclonus	0.9%
817	Myotonia	0.9%
818	Neuralgia	0.9%
819	Paraplegia	0.9%
820	Pseudobulbar Palsy	0.9%
821	Quadriplegia	0.9%
822	Spasm	0.9%
823	Spastic Paraplegia	0.9%
824	Status Epilepticus	0.9%
825	Taste Disorders	0.9%
826	Tremor	0.9%
827	Monoplegia	0.9%
828	Hypokinesia	0.9%
829	Paraparesis	0.9%
830	Bradykinesia	0.9%
831	Waxy flexibility	0.9%
832	Action Tremor	0.9%
833	Resting Tremor	0.9%
834	Dysosmia	0.9%
835	Quadriparesis	0.9%
836	Mercury Poisoning, Nervous System	0.9%
837	Olfaction Disorders	0.9%
838	Myokymia	0.9%
839	Lead Poisoning, Nervous System	0.9%
840	Vestibular Neuronitis	0.9%
841	Somatosensory Disorders	0.9%
842	Neuropathic pain	0.9%
843	Hyperkinesia	0.9%
844	Intention tremor	0.9%
845	Tarsal Tunnel Syndrome	0.9%
846	Cauda Equina Syndrome	0.9%
847	Hand-Arm Vibration Syndrome	0.8%
848	Vision Disorders	0.8%
849	Metamorphopsia	0.8%
850	Visual Impairment	0.8%
851	Fibromyalgia	0.8%
852	Optic Neuropathy, Ischemic	0.8%
853	Anterior Ischemic Optic Neuropathy	0.8%
854	Medial Tibial Stress Syndrome	0.8%
855	Facial Hemiatrophy	0.8%
856	Melkersson-Rosenthal Syndrome	0.8%
857	Anisocoria	0.8%
858	Confusion	0.8%
859	Facial paralysis	0.8%
860	Lethargy	0.8%
861	Memory Disorders	0.8%
862	Muscle Cramp	0.8%
863	Perceptual Disorders	0.8%
864	Psychomotor Disorders	0.8%
865	Tonic Pupil	0.8%
866	Eosinophilia-Myalgia Syndrome	0.8%
867	Anhedonia	0.8%
868	Disorientation	0.8%
869	Facial Paresis	0.8%
870	Memory Loss	0.8%
871	Hemisensory Neglect	0.8%
872	Dysacusis	0.8%
873	Sleep Bruxism	0.8%
874	Muscular Atrophy	0.8%
875	Respiratory Paralysis	0.8%
876	Carpal Tunnel Syndrome	0.8%
877	Aortopulmonary Septal Defect	0.8%
878	Double Outlet Right Ventricle	0.8%
879	Endocardial Cushion Defects	0.8%
880	neurofibroma	0.8%
881	Myocardial bridging	0.8%
882	Aorticopulmonary Septal Defect	0.8%
883	Sciatica	0.8%
884	Consciousness Disorders	0.7%
885	Mental Retardation	0.7%
886	Muscle Weakness	0.7%
887	Depressed Level of Consciousness	0.7%
888	Mental deficiency	0.7%
889	Intellectual Disability	0.7%
890	Bell Palsy	0.7%
891	Catatonia	0.7%
892	Herpes Zoster Oticus	0.7%
893	Aphonia	0.7%
894	Sleep Deprivation	0.7%
895	Dysphonia	0.7%
896	Mandibulofacial Dysostosis	0.7%
897	Romano-Ward Syndrome	0.7%
898	Myalgia	0.7%
899	Cubital Tunnel Syndrome	0.6%
900	Truncus Arteriosus, Persistent	0.6%
901	Goldenhar Syndrome	0.6%
902	Hoarseness	0.6%
903	Alcohol Withdrawal Delirium	0.6%
904	Arteriovenous fistula	0.6%
905	Sciatic Neuropathy	0.6%
906	Ulnar Neuropathies	0.6%
907	Lesion of Sciatic Nerve	0.6%
908	Ulnar Neuritis	0.6%
909	Radial nerve compression	0.6%
910	Radial Tunnel Syndrome	0.6%
911	Peroneal Neuropathies	0.6%
912	Radial Neuropathy	0.6%
913	Median Neuropathy	0.6%
914	Sciatic Nerve Palsy	0.6%
915	Femoral Neuropathy	0.6%
916	Tibial Neuropathy	0.6%
917	Ulnar Nerve Palsy	0.6%
918	Postural Orthostatic Tachycardia Syndrome	0.6%
919	Radial nerve palsy	0.6%
920	Talipes	0.6%
921	Thoracic Outlet Syndrome	0.5%
922	Esotropia	0.5%
923	Exotropia	0.5%
924	Hypotension, Orthostatic	0.5%
925	Sleep Apnea Syndromes	0.5%
926	Polymyositis	0.5%
927	Post-Exercise Hypotension	0.5%
928	Disorders of Excessive Somnolence	0.5%
929	Sleep Initiation and Maintenance Disorders	0.5%
930	Night Terrors	0.5%
931	Somnambulism	0.5%
932	Trigeminal Nerve Disorder	0.5%
933	Transient Insomnia	0.5%
934	Sleep Paralysis	0.5%
935	Chronic Insomnia	0.5%
936	REM Sleep Behavior Disorder	0.5%
937	Hypersomnia	0.5%
938	Dysgeusia	0.5%
939	Formication	0.5%
940	Hyperalgesia	0.5%
941	Hyperesthesia	0.5%
942	Hypesthesia	0.5%
943	Language Disorders	0.5%
944	Numbness	0.5%
945	Paresthesia	0.5%
946	Paraparesis, Spastic	0.5%
947	Trismus	0.5%
948	Epilepsia Partialis Continua	0.5%
949	Hypogeusia	0.5%
950	Meningeal Carcinomatosis	0.5%
951	Brown-Sequard Syndrome	0.5%
952	Lockjaw	0.5%
953	Allodynia	0.5%
954	Lead Poisoning, Nervous System, Childhood	0.5%
955	Lead Poisoning, Nervous System, Adult	0.5%
956	Ageusia	0.5%
957	Alexia	0.5%
958	Dyslexia	0.5%
959	Congenital clubfoot	0.5%
960	Vertical Talus	0.5%
961	Eye Injuries	0.5%
962	Orbital Myositis	0.5%
963	Diplopia	0.5%
964	Muscle Rigidity	0.5%
965	Muscle Spasticity	0.5%
966	Scotoma	0.5%
967	Photophobia	0.5%
968	Cogwheel Rigidity	0.5%
969	Hemifacial Spasm	0.5%
970	Amaurosis	0.5%
971	Blindness	0.5%
972	Nuchal Rigidity	0.5%
973	Pyomyositis	0.5%
974	Agnosia	0.5%
975	Apraxias	0.5%
976	Hallucinations	0.5%
977	Hemianopsia	0.5%
978	Hyperacusis	0.5%
979	Tinnitus	0.5%
980	Visual Agnosia	0.5%
981	Anosognosia	0.5%
982	Wernicke-Korsakoff Syndrome	0.5%
983	Phonophobia	0.5%
984	Hearing Loss	0.5%
985	Sarcopenia	0.5%
986	Neurofibrosarcoma	0.5%
987	Amnesia	0.4%
988	Delirium	0.4%
989	Dissociative Amnesia	0.4%
990	Color blindness	0.4%
991	Global Amnesia	0.4%
992	Meningioma	0.4%
993	Phantom pain	0.4%
994	Phantom Limb Pain	0.4%
995	Polyradiculopathy	0.4%
996	Sleep Apnea, Obstructive	0.4%
997	Sleep Apnea, Central	0.4%
998	Narcolepsy	0.4%
999	Trigeminal Neuralgia	0.4%
1000	Kleine-Levin Syndrome	0.4%
1001	Agraphia	0.4%
1002	Anomia	0.4%
1003	Cluttering	0.4%
1004	Language Development Disorders	0.4%
1005	Speech Disorders	0.4%
1006	Syncope	0.4%
1007	Stupor	0.4%
1008	Dysgraphia	0.4%
1009	Presyncope	0.4%
1010	Dyslalia	0.4%
1011	Eye Burns	0.3%
1012	Amaurosis Fugax	0.3%
1013	Blindness, Cortical	0.3%
1014	Dyscalculia	0.3%
1015	Deafness	0.3%
1016	Hearing Loss, Sudden	0.3%
1017	Gerstmann Syndrome	0.3%
1018	Hearing Loss, Bilateral	0.3%
1019	Hearing Loss, High-Frequency	0.3%
1020	Hearing Loss, Mixed Conductive-Sensorineural	0.3%
1021	Prosopagnosia	0.3%
1022	Apraxia, Ideomotor	0.3%
1023	Charles Bonnet Syndrome	0.3%
1024	Hearing Loss, Unilateral	0.3%
1025	Complete Hearing Loss	0.3%
1026	Alien Hand Syndrome	0.3%
1027	Deaf Mutism	0.3%
1028	Dermatomyositis	0.3%
1029	Corneal Scar	0.3%
1030	Retrograde amnesia	0.3%
1031	Amnesia, Anterograde	0.3%
1032	Cataplexy	0.3%
1033	Aphasia	0.3%
1034	Articulation Disorders	0.3%
1035	Echolalia	0.3%
1036	Stuttering	0.3%
1037	Dysphasia	0.3%
1038	Mutism	0.2%
1039	Selective Mutism	0.2%
1040	Dysarthria	0.2%
1041	Corneal Perforation	0.2%
1042	Alexia, Pure	0.2%

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