MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Erythromelalgia

(UMLS:C0014804)

Definition:: A peripheral arterial disease that is characterized by the triad of ERYTHEMA, burning PAIN, and increased SKIN TEMPERATURE of the extremities (or red, painful extremities). Erythromelalgia may be classified as primary or idiopathic, familial or non-familial. Secondary erythromelalgia is associated with other diseases, the most common being MYELOPROLIFERATIVE DISORDERS.
UMLS ID:: C0014804
MeSH ID:: D004916

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.617.500

Synonym(s)

Erythromelalgia

ERYTHERMALGIA

ERYTHROMELALGIA

Erythermalgia

Erythralgia

GERHARDT DISEASE

MITCHELL DISEASE

Mitchell

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	4-hydroxybutyric acid	FAERS: 3		US FAERS
2	Capecitabine	FAERS: 3		US FAERS
3	Fingolimod Hydrochloride	FAERS: 3		US FAERS
4	Nitrofurantoin	FAERS: 3 Canada Vigilance: 2		Canada Vigilance US FAERS
5	Zoledronic Acid	FAERS: 3		US FAERS
6	Decitabine	FAERS: 2		US FAERS
7	Imatinib Mesylate	FAERS: 2		US FAERS
8	Levofloxacin	FAERS: 2		US FAERS
9	Methylphenidate	FAERS: 2		US FAERS
10	Minoxidil	FAERS: 2		OFFSIDES US FAERS
11	Pregabalin	FAERS: 2		US FAERS
12	4-Aminopyridine	FAERS: 1		US FAERS
13	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
14	Amlodipine	FAERS: 1		US FAERS
15	Citalopram	FAERS: 1		US FAERS
16	Clindamycin	FAERS: 1		US FAERS
17	Dimethyl Fumarate	FAERS: 1		US FAERS
18	Etodolac	FAERS: 1		US FAERS
19	Fenofibrate	FAERS: 1		US FAERS
20	Imatinib Mesylate	FAERS: 1		US FAERS
21	Isotretinoin	FAERS: 1		US FAERS
22	Ivermectin	FAERS: 1		US FAERS
23	Methylprednisolone Acetate	FAERS: 1		US FAERS
24	Nortriptyline	FAERS: 1		US FAERS
25	Ruxolitinib phosphate	FAERS: 1		US FAERS
26	Teriparatide	FAERS: 1		US FAERS
27	eltrombopag	FAERS: 1		US FAERS
28	oxybutynin	FAERS: 1		US FAERS
29	Amantadine			OFFSIDES
30	Anastrozole			OFFSIDES
31	Aspirin		16510297	CTD
32	Bortezomib			SIDER
33	Bromocriptine	Canada Vigilance: 1	6213882	CTD SIDER Canada Vigilance
34	Carbamazepine		19549232 19557861	CTD
35	Cytarabine			OFFSIDES
36	Flavoxate			OFFSIDES
37	Gabapentin		19549232 22170168	CTD
38	Hydroxyurea			OFFSIDES
39	Iloprost			OFFSIDES
40	Lidoderm		22170168	CTD
41	Lisuride			SIDER
42	Mexiletine		19162012 22170168	CTD
43	Nicardipine		2502240 2503135 2504422	CTD
44	Nifedipine		8740329	CTD SIDER
45	Pergolide		6743541	CTD OFFSIDES
46	Pramipexole			OFFSIDES
47	Semaxinib			SIDER
48	Tolterodine Tartrate			OFFSIDES
49	Verapamil		1390176 17954955	CTD
50	Zonisamide			OFFSIDES
51	carbidopa, levodopa drug combination			OFFSIDES
52	danthron			OFFSIDES
53	exemestane			OFFSIDES
54	lormetazepam			OFFSIDES
55	ropinirole			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Raynaud Disease	46.7%
2	Periphlebitis	44.4%
3	Phlebitis	44.4%
4	Blue Toe Syndrome	37.9%
5	Postphlebitic Syndrome	36.3%
6	Aneurysm	31%
7	Angiomatosis	31%
8	Aortic Diseases	31%
9	Arterial Occlusive Diseases	31%
10	Hyperemia	31%
11	Hypotension	31%
12	Superior Vena Cava Syndrome	31%
13	Telangiectasis	31%
14	Vasculitis	31%
15	Venous Insufficiency	31%
16	Embolism and Thrombosis	31%
17	Angiodysplasia	31%
18	Capillary Leak Syndrome	31%
19	Prehypertension	31%
20	Thrombophlebitis	30.4%
21	Myocardial Ischemia	27.9%
22	Aortic Aneurysm	26.7%
23	Aortitis	26.7%
24	Leriche Syndrome	26.7%
25	Thromboangiitis Obliterans	26.7%
26	May-Thurner Syndrome	26.4%
27	Livedo Reticularis	23.3%
28	Vascular System Injuries	22%
29	Retinal Vein Occlusion	21.7%
30	Compartment syndromes	20.9%
31	Hepatic Veno-Occlusive Disease	20.9%
32	Peliosis Hepatis	20.9%
33	Varicocele	20.9%
34	Cerebrovascular Disorders	20.5%
35	Diabetic Angiopathies	20.5%
36	Reperfusion Injury	20.5%
37	Splenic Infarction	20.5%
38	Cerebrovascular Insufficiency	20.5%
39	Vascular Neoplasms	20.5%
40	Spinal Cord Vascular Diseases	20.5%
41	Vasoplegia	20.5%
42	Hemorrhoids	20.2%
43	Thoracic Outlet Syndrome	20.2%
44	Aneurysm, Dissecting	20%
45	Arteriosclerosis	20%
46	Arteritis	20%
47	Embolism	20%
48	Fibromuscular Dysplasia	20%
49	Malignant Hypertension	20%
50	Thromboembolism	20%
51	Thrombosis	20%
52	Essential Hypertension	20%
53	Aneurysm, Ruptured	20%
54	Iliac Aneurysm	20%
55	Malignant Atrophic Papulosis	20%
56	Pulmonary artery stenosis	20%
57	White Coat Hypertension	20%
58	Systemic Vasculitis	20%
59	Embolus	20%
60	Shwartzman Phenomenon	19.8%
61	Coronary Aneurysm	19.7%
62	Aortic Aneurysm, Abdominal	19.6%
63	Aortic Aneurysm, Thoracic	19.6%
64	Heart Diseases	18.5%
65	Aortic Rupture	17.9%
66	Coronary heart disease	17.8%
67	Myocardial Infarction	17.8%
68	Acute Coronary Syndrome	17.8%
69	Myocardial Reperfusion Injury	17.7%
70	Intracranial Embolism and Thrombosis	17.2%
71	Carotid Stenosis	17.1%
72	Intracranial Aneurysm	17.1%
73	Coronary Thrombosis	17.1%
74	Coronary Artery Disease	17.1%
75	Carotid Artery Thrombosis	16.5%
76	Hand-Arm Vibration Syndrome	16.1%
77	Optic Neuropathy, Ischemic	15.5%
78	Anterior Ischemic Optic Neuropathy	15.5%
79	Mesenteric vascular insufficiency	15.5%
80	Moyamoya Disease	15.3%
81	CREST Syndrome	15.3%
82	Angioedema	15%
83	Lemierre Syndrome	15%
84	Colitis, Ischemic	14.9%
85	Arteriosclerosis Obliterans	14.8%
86	Atherosclerosis	14.8%
87	Air Embolism	14.8%
88	Endarteritis	14.8%
89	Polyarteritis Nodosa	14.8%
90	Takayasu Arteritis	14.8%
91	Venous Thrombosis	14.8%
92	Deep Vein Thrombosis	14.8%
93	Venous Thromboembolism	14.8%
94	Intracranial Arteriosclerosis	14.6%
95	Cerebral Atherosclerosis	14.6%
96	Cerebral Arteriosclerosis	14.6%
97	Arteriovenous fistula	14%
98	Retinal Artery Occlusion	13.6%
99	Retinal Vasculitis	13.6%
100	Hypertensive Retinopathy	13.6%
101	Kounis Syndrome	13.6%
102	Vasculitis, Central Nervous System	13.4%
103	Anterior Compartment Syndrome	13.3%
104	Vasculitis, Leukocytoclastic, Cutaneous	13.3%
105	Gastric Antral Vascular Ectasia	13.3%
106	Abdominal Compartment Syndrome	13.3%
107	Cerebral Thrombosis	13.3%
108	Intracranial Embolism	13.3%
109	Intracranial Thrombosis	13.3%
110	Carotid Artery Diseases	13.2%
111	Brain Ischemia	13.2%
112	Hypotension, Orthostatic	13.2%
113	Cerebrovascular accident	13.2%
114	Varicose Ulcer	13.2%
115	Vasospasm, Intracranial	13.2%
116	Spinal Cord Ischemia	13.2%
117	Intracranial Arterial Diseases	13.2%
118	Primary Graft Dysfunction	13.2%
119	Post-Exercise Hypotension	13.2%
120	Angina Pectoris	13.2%
121	Coronary Occlusion	13%
122	Microvascular Angina	13%
123	Coronary Stenosis	13%
124	ST segment elevation myocardial infarction	13%
125	Embolism, Amniotic Fluid	12.6%
126	Pregnancy Complications, Cardiovascular	12.2%
127	Cardiovascular Abnormalities	12.2%
128	Brain Infarction	11.6%
129	Sinus Thrombosis, Intracranial	11.4%
130	Giant Cell Arteritis	11%
131	Temporal Arteritis	11%
132	Coronary Restenosis	10.8%
133	Scimitar Syndrome	10.7%
134	Cavernous Sinus Thrombosis	10.5%
135	Sagittal Sinus Thrombosis	10.5%
136	Cardiac Tamponade	10.3%
137	Endocarditis	10.3%
138	Cardiac Arrest	10.3%
139	Heart failure	10.3%
140	Pericardial effusion	10.3%
141	Pericarditis	10.3%
142	Pneumopericardium	10.3%
143	Cor pulmonale	10.3%
144	Ventricular Outflow Obstruction	10.3%
145	Ventricular Dysfunction	10.3%
146	Cardiomyopathies	10.3%
147	Pleuropericarditis	10.3%
148	Mesenteric Vascular Occlusion	10.2%
149	Mucocutaneous Lymph Node Syndrome	10.2%
150	Intermittent Claudication	10.1%
151	Pulmonary Embolism	10.1%
152	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	10.1%
153	Diabetic Retinopathy	10.1%
154	Sturge-Weber Syndrome	10.1%
155	Renal hypertension	9.9%
156	Renal Artery Obstruction	9.9%
157	Renal Artery Stenosis	9.9%
158	No-Reflow Phenomenon	9.9%
159	Hemangioma, Cavernous	9.8%
160	Shock, Cardiogenic	9.8%
161	Basal Ganglia Cerebrovascular Disease	9.8%
162	Vertebral Artery Dissection	9.8%
163	Vascular Headaches	9.8%
164	Scurvy	9.8%
165	Cerebral Arterial Diseases	9.7%
166	Vertebrobasilar Insufficiency	9.7%
167	Anterior Spinal Artery Syndrome	9.7%
168	Basilar Artery Stenosis	9.7%
169	Vertebral Artery Stenosis	9.7%
170	Intracranial Hemorrhage, Hypertensive	9.7%
171	Transient Cerebral Ischemia	9.7%
172	Angina, Unstable	9.7%
173	Subarachnoid Hemorrhage, Traumatic	9.6%
174	Carotid Artery, Internal, Dissection	9.6%
175	Cerebral Infarction	9.6%
176	Brain Stem Infarctions	9.6%
177	Infarction, Middle Cerebral Artery	9.5%
178	Infarction, Anterior Cerebral Artery	9.5%
179	Infarction, Posterior Cerebral Artery	9.5%
180	Aortic Valve Stenosis	8.9%
181	Cardiomyopathy, Dilated	8.9%
182	Pulmonary Valve Stenosis	8.9%
183	Lateral Medullary Syndrome	8.6%
184	Hepatic Vein Thrombosis	8.4%
185	Budd-Chiari Syndrome	8.4%
186	Carotid Artery Injuries	8.4%
187	Pulmonary Infarction	8.2%
188	Subclavian Steal Syndrome	8%
189	Angina Pectoris, Variant	8%
190	Ischemic contracture	8%
191	Angioedemas, Hereditary	7.9%
192	Tricuspid Atresia	7.9%
193	Arrhythmogenic Right Ventricular Dysplasia	7.9%
194	Cryoglobulinemia	7.9%
195	Leukomalacia, Periventricular	7.9%
196	Diabetic Foot	7.8%
197	Basal Ganglia Hemorrhage	7.5%
198	Hypertension, Renovascular	7.3%
199	Subarachnoid Hemorrhage	7.3%
200	Hypoxia-Ischemia, Brain	7.3%
201	Cerebral Hemorrhage	7.3%
202	Hereditary Angioedema Type III	7.2%
203	Hereditary Angioedema Types I and II	7.2%
204	Hypertrophic Cardiomyopathy	7.1%
205	Hypertrophic obstructive cardiomyopathy	7.1%
206	Cardiac Output, High	7%
207	Myocardial Stunning	7%
208	Low Cardiac Output Syndrome	7%
209	Bacterial Endocarditis	6.8%
210	Cardiomegaly	6.8%
211	Postpericardiotomy Syndrome	6.8%
212	Cardiac Hypertrophy	6.8%
213	Rheumatic Heart Disease	6.7%
214	Aortic Valve Insufficiency	6.7%
215	Restrictive cardiomyopathy	6.7%
216	Endocardial Fibroelastosis	6.7%
217	Heart Block	6.7%
218	Heart Rupture, Post-Infarction	6.7%
219	Mitral Valve Insufficiency	6.7%
220	Mitral Valve Stenosis	6.7%
221	Myocarditis	6.7%
222	Pericarditis, Constrictive	6.7%
223	Pulmonary Valve Insufficiency	6.7%
224	Tachycardia	6.7%
225	Tricuspid Valve Insufficiency	6.7%
226	Tricuspid Valve Stenosis	6.7%
227	Tachyarrhythmia	6.7%
228	Ventricular Dysfunction, Left	6.7%
229	Right Ventricular Dysfunction	6.7%
230	Endomyocardial Fibrosis	6.7%
231	Carditis	6.7%
232	Heart Failure, Systolic	6.7%
233	Heart Failure, Diastolic	6.7%
234	Aortic coarctation	6.6%
235	Cor Triatriatum	6.6%
236	Coronary Vessel Anomalies	6.6%
237	Patent ductus arteriosus	6.6%
238	Ebstein Anomaly	6.6%
239	Heart Septal Defects	6.6%
240	Tetralogy of Fallot	6.6%
241	Transposition of Great Vessels	6.6%
242	Hypoplastic Left Heart Syndrome	6.6%
243	Shy-Drager Syndrome	6.5%
244	Supravalvular aortic stenosis	6.5%
245	Lown-Ganong-Levine Syndrome	6.5%
246	Purpura, Hyperglobulinemic	6.5%
247	Putaminal Hemorrhage	6.5%
248	Granulomatosis with polyangiitis	6.2%
249	Dementia, Vascular	6.1%
250	Cerebral Amyloid Angiopathy	6%
251	Pituitary Apoplexy	5.9%
252	Behcet Syndrome	5.7%
253	Waldenstrom Macroglobulinemia	5.7%
254	Multiple Myeloma	5.7%
255	Dextrocardia	5.3%
256	Long QT Syndrome	5.3%
257	Ataxia Telangiectasia	5.1%
258	Pseudoxanthoma Elasticum	5%
259	Aortic Valve Prolapse	4.9%
260	Tricuspid Valve Prolapse	4.9%
261	Rheumatoid Vasculitis	4.9%
262	Takotsubo Cardiomyopathy	4.9%
263	Adams-Stokes Syndrome	4.9%
264	Atrioventricular Block	4.9%
265	Bundle-Branch Block	4.9%
266	Atrial Premature Complexes	4.9%
267	Sinoatrial Block	4.9%
268	Tachycardia, Paroxysmal	4.9%
269	Supraventricular tachycardia	4.9%
270	Tachycardia, Ventricular	4.9%
271	Wolff-Parkinson-White Syndrome	4.9%
272	Tachycardia, Reciprocating	4.9%
273	Lupus Vasculitis, Central Nervous System	4.9%
274	Sick Sinus Syndrome	4.9%
275	Aortopulmonary Septal Defect	4.9%
276	Double Outlet Right Ventricle	4.9%
277	Endocardial Cushion Defects	4.9%
278	Myocardial bridging	4.9%
279	Aorticopulmonary Septal Defect	4.9%
280	Sinus Arrhythmia	4.4%
281	Atrial Fibrillation	4.4%
282	Atrial Flutter	4.4%
283	Edema, Cardiac	4.4%
284	Ventricular Fibrillation	4.4%
285	Ventricular Flutter	4.4%
286	Parasystole	4.4%
287	Paroxysmal atrial fibrillation	4.4%
288	Bradycardia	4.4%
289	Diabetic Cardiomyopathies	4.4%
290	Cardiomyopathy, Alcoholic	4.4%
291	Ectopia Cordis	4.4%
292	Sudden Cardiac Death	4.4%
293	Left Ventricular Hypertrophy	4.4%
294	Right Ventricular Hypertrophy	4.4%
295	Single umbilical artery	4.4%
296	Chagas Cardiomyopathy	4.4%
297	Tachycardia, Atrioventricular Nodal Reentry	4%
298	Tachycardia, Ectopic Atrial	4%
299	Tachycardia, Ectopic Junctional	4%
300	Sinus Tachycardia	4%
301	Torsades de Pointes	4%
302	Accelerated Idioventricular Rhythm	4%
303	Truncus Arteriosus, Persistent	4%
304	Carcinoid Heart Disease	3.9%
305	Romano-Ward Syndrome	3.9%
306	Subacute Bacterial Endocarditis	3.8%
307	Noonan Syndrome	3.8%
308	Hematoma, Subdural	3.5%
309	Hematoma, Epidural, Cranial	3.5%
310	Marfan Syndrome	3.4%
311	Dyspnea, Paroxysmal	3.3%
312	Sinus Arrest, Cardiac	3.3%
313	Hematoma, Subdural, Intracranial	3.1%
314	Hematoma, Subdural, Chronic	3.1%
315	Hematoma, Subdural, Acute	3.1%
316	Brain Hemorrhage, Traumatic	3%
317	MELAS Syndrome	2.9%
318	Dural Arteriovenous Fistula	2.7%
319	Fabry Disease	2.2%
320	Turner Syndrome	1.8%
321	Williams Syndrome	1.6%
322	Kartagener Syndrome	1.5%
323	Kearns-Sayre syndrome	1.2%

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