MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Wernicke Encephalopathy

(UMLS:C0043121)

Definition:: An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
UMLS ID:: C0043121
MeSH ID:: D014899

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.960

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.960|C18.654.521.500.133.699.827.822

Classification 3:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.775.100.625

Classification 4:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.900.100.875

Synonym(s)

Wernicke Encephalopathy

ENCEPHALOPATHY WERNICKE

ENCEPHALOPATHY, WERNICKE

Encephalopathy;wernickes

GAYET-WERNICKE SYNDROME

Korsakoff's psychosis, alcohol related

WERNICKE

Wernicke disease

Wernicke encephalopathy

10.

Wernicke's Syndrome

11.

Wernicke's disease

12.

Wernicke's encephalopathy

13.

Wernicke; disease or syndrome (manifestation)

14.

Wernickes Syndrome

15.

disease wernickes

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Lithium Carbonate	2499199	CTD
2	Thiamine	View details 2499199 6410237 8765181 14644703 17583600 19654964 20426524	CTD
3	Tolazamide	3762968 6410237	CTD
4	Zidovudine	2882316	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Brain Diseases, Metabolic, Inborn	27.1%
2	Myelinolysis, Central Pontine	26.9%
3	Alcohol Use Disorder	26.3%
4	Alcoholic Intoxication	26.3%
5	Alcohol abuse	26.3%
6	Reye Syndrome	24.7%
7	Hepatic Encephalopathy	24.6%
8	Mitochondrial Encephalomyopathies	23.6%
9	Binge Drinking	23%
10	Alcohol Withdrawal Delirium	22.5%
11	Leigh Disease	20.8%
12	Psychoses, Alcoholic	20.4%
13	Wasting Syndrome	19.4%
14	Adrenoleukodystrophy	19.2%
15	Galactosemias	19.1%
16	Urea Cycle Disorders, Inborn	19.1%
17	Tyrosinemias	19.1%
18	Hepatolenticular Degeneration	18.6%
19	Beriberi	18.3%
20	Hyperhomocysteinemia	18.1%
21	Kernicterus	18.1%
22	Carbamoyl-Phosphate Synthase I Deficiency Disease	18.1%
23	MELAS Syndrome	17.3%
24	Psychoses, Substance-Induced	17.2%
25	Marijuana Abuse	17.2%
26	Opioid-Related Disorders	17.2%
27	Nicotine Dependence	17.2%
28	Opioid abuse	17.2%
29	Phencyclidine Abuse	17.2%
30	Substance Abuse, Intravenous	17.2%
31	Substance Withdrawal Syndrome	17.2%
32	Tobacco Use Disorder	17.2%
33	Amphetamine-Related Disorders	17.2%
34	Cocaine-Related Disorders	17.2%
35	Homocystinuria	17.1%
36	Marchiafava-Bignami Disease	16.5%
37	Canavan Disease	15.4%
38	Alexander Disease	15.4%
39	Rickets	15.3%
40	Alcohol-Induced Disorders	15.3%
41	Neonatal Abstinence Syndrome	15.2%
42	Glycogen storage disease type II	15.1%
43	Dementia, Vascular	14.8%
44	Refsum Disease	14.5%
45	Menkes Kinky Hair Syndrome	14.3%
46	Gaucher Disease	14.3%
47	Zellweger Syndrome	14.2%
48	Folic Acid Deficiency	14%
49	Pellagra	14%
50	Vitamin B 12 Deficiency	14%
51	Vitamin B 6 Deficiency	14%
52	Pyridoxine Deficiency	14%
53	Meningoencephalitis	13.8%
54	Fabry Disease	13.7%
55	Hypercalcemia	13.3%
56	Hypocalcemia	13.3%
57	Milk-Alkali Syndrome	13.3%
58	Lewy Body Disease	13%
59	Dementia	12.8%
60	Tay-Sachs Disease	12.7%
61	Subdural Effusion	12.6%
62	Pseudohypoparathyroidism	12.6%
63	Alcohol-Induced Disorders, Nervous System	12.4%
64	Niemann-Pick Disease, Type C	12.3%
65	Subacute Combined Degeneration	12.3%
66	Acid-Base Imbalance	12.2%
67	Calcium Metabolism Disorders	12.2%
68	Iron Metabolism Disorders	12.2%
69	Phosphorus Metabolism Disorders	12.2%
70	Water-Electrolyte Imbalance	12.2%
71	Lipid Metabolism Disorders	12.2%
72	Mitochondrial Diseases	12.2%
73	Glucose Metabolism Disorders	12.2%
74	Dandy-Walker Syndrome	12.1%
75	Huntington Disease	11.9%
76	Ascorbic Acid Deficiency	11.9%
77	Vitamin A Deficiency	11.9%
78	Vitamin D Deficiency	11.9%
79	Vitamin E Deficiency	11.9%
80	Lipodystrophy	11.6%
81	Akinetic Mutism	11.5%
82	Anoxic Encephalopathy	11.5%
83	Basal Ganglia Diseases	11.5%
84	Brain Damage, Chronic	11.5%
85	Cerebellar Diseases	11.5%
86	Encephalitis	11.5%
87	Encephalomalacia	11.5%
88	Epilepsy	11.5%
89	Hydrocephalus	11.5%
90	Congenital Hydrocephalus	11.5%
91	Hypothalamic Diseases	11.5%
92	Thalamic Diseases	11.5%
93	Intracranial Hypertension	11.5%
94	Aura	11.5%
95	Leukoencephalopathy	11.5%
96	Neuroaxonal Dystrophies	11.5%
97	Headache Disorders	11.5%
98	Intracranial Hypotension	11.5%
99	Brain Edema	11.5%
100	Brain Hypoxia	11.5%
101	Aqueductal Stenosis	11.5%
102	Alcohol Withdrawal Seizures	11.4%
103	Basal Ganglia Cerebrovascular Disease	11.4%
104	Multiple System Atrophy	11.4%
105	Encephalomyelitis	11.4%
106	Posterior Leukoencephalopathy Syndrome	11.4%
107	Posterior reversible encephalopathy syndrome	11.4%
108	Pneumocephalus	11.3%
109	Heroin Dependence	11.3%
110	Morphine Dependence	11.3%
111	Brain Abscess	11%
112	Osteomalacia	10.8%
113	Epilepsy, Post-Traumatic	10.8%
114	Magnesium Deficiency	10.8%
115	Potassium Deficiency	10.8%
116	Protein Deficiency	10.8%
117	Parkinsonian Disorders	10.8%
118	Familial Hypophosphatemic Rickets	10.7%
119	Friedreich Ataxia	10.6%
120	Osteopenia	10.6%
121	Starvation	10.3%
122	Refeeding Syndrome	10.3%
123	Leukomalacia, Periventricular	10.2%
124	Child Nutrition Disorders	10.2%
125	Hypervitaminosis A	10.2%
126	Infant Nutrition Disorders	10.2%
127	Vascular Headaches	10%
128	Cerebrovascular Disorders	10%
129	Cerebrovascular Insufficiency	10%
130	Hypoxia-Ischemia, Brain	9.9%
131	Brain Injuries	9.9%
132	Brain Neoplasms	9.8%
133	Cardiomyopathy, Alcoholic	9.8%
134	Pancreatitis, Alcoholic	9.8%
135	Creutzfeldt-Jakob disease	9.8%
136	Myoclonic Epilepsy	9.7%
137	Epilepsy, Temporal Lobe	9.7%
138	Epilepsy, Rolandic	9.7%
139	Benign Rolandic Epilepsy	9.7%
140	Water Intoxication	9.5%
141	Neuroleptic Malignant Syndrome	9.5%
142	Cerebellar Neoplasms	9.3%
143	Meige Syndrome	9.3%
144	Cerebral Ventriculitis	9.3%
145	Amyotrophic Lateral Sclerosis	9.3%
146	Brain Death	9.1%
147	Smith-Lemli-Opitz Syndrome	9%
148	Vitamin K Deficiency	9%
149	Parkinson Disease	8.8%
150	Lactose Intolerance	8.8%
151	Hyperlipoproteinemia Type IV	8.8%
152	Hyperlipoproteinemia Type V	8.8%
153	Epidural Abscess	8.7%
154	Basal Ganglia Hemorrhage	8.7%
155	Leukoencephalopathy, Progressive Multifocal	8.7%
156	Fetal Alcohol Spectrum Disorders	8.7%
157	Amnesia, Transient Global	8.6%
158	Presenile dementia	8.6%
159	Senile dementia	8.6%
160	Ocular Motility Disorders	8.6%
161	Cyclophoria	8.6%
162	Amyloid Neuropathies, Familial	8.5%
163	Frontotemporal dementia	8.5%
164	Drug Overdose	8.5%
165	Myelitis	8.5%
166	Kluver-Bucy Syndrome	8.4%
167	Amblyopia	8.4%
168	Dystonia Musculorum Deformans	8.4%
169	Meningitis	8.3%
170	Movement Disorders	8.3%
171	Pachymeningitis	8.3%
172	Spinal Cord Diseases	8.3%
173	Anemia, Pernicious	8.3%
174	Hypolipoproteinemias	8.2%
175	Sleep Wake Disorders	8.2%
176	Lupus Vasculitis, Central Nervous System	8.2%
177	Hyperphosphaturia	8.2%
178	Progressive supranuclear palsy	8.2%
179	Renal Osteodystrophy	8.1%
180	Renal rickets	8.1%
181	MPTP Poisoning	8.1%
182	Juvenile Myoclonic Epilepsy	8.1%
183	Myoclonic Epilepsies, Progressive	8.1%
184	Ataxia Telangiectasia	8.1%
185	HIV Wasting Syndrome	8%
186	Akathisia, Drug-Induced	8%
187	Neurotic Disorders	7.8%
188	Pituitary Adenoma	7.8%
189	Pituitary Neoplasms	7.8%
190	Striatonigral Degeneration	7.8%
191	Acidosis	7.7%
192	Alkalosis	7.7%
193	Amyloidosis	7.7%
194	Calcinosis	7.7%
195	Hyperglycemia	7.7%
196	Hyperinsulinism	7.7%
197	Hyperkalemia	7.7%
198	Hypernatremia	7.7%
199	Hypoglycemia	7.7%
200	Hypokalemia	7.7%
201	Hyponatremia	7.7%
202	Xanthomatosis	7.7%
203	Hypophosphatemia	7.7%
204	Metabolic acidosis	7.7%
205	Dyslipidemias	7.7%
206	Iron Overload	7.7%
207	Xanthoma	7.7%
208	Pituitary Apoplexy	7.6%
209	Cerebral Amyloid Angiopathy	7.6%
210	Cerebral Palsy	7.6%
211	Epilepsies, Partial	7.6%
212	Epilepsy, Generalized	7.6%
213	Pseudotumor Cerebri	7.6%
214	Hypertensive Encephalopathy	7.6%
215	Simple Partial Seizures	7.6%
216	Epilepsy, Reflex	7.6%
217	Headache Disorders, Primary	7.6%
218	Headache Disorders, Secondary	7.6%
219	Medication overuse headache	7.6%
220	Brain Infarction	7.6%
221	Limbic Encephalitis	7.5%
222	Congenital Hyperinsulinism	7.5%
223	Diabetic Ketoacidosis	7.4%
224	Hyperlipidemia, Familial Combined	7.4%
225	Putaminal Hemorrhage	7.4%
226	Central Nervous System Infection	7.3%
227	Neurotoxicity Syndromes	7.3%
228	Leukoencephalitis, Acute Hemorrhagic	7.3%
229	Dyskinesia, Drug-Induced	7.3%
230	Brain Hemorrhage, Traumatic	7.2%
231	Fatty Liver, Alcoholic	7.2%
232	Hepatitis, Alcoholic	7.2%
233	Liver Cirrhosis, Alcoholic	7.2%
234	Infarction, Middle Cerebral Artery	7.1%
235	Infarction, Anterior Cerebral Artery	7.1%
236	Infarction, Posterior Cerebral Artery	7.1%
237	Mitochondrial Myopathies	7.1%
238	Carotid Artery Injuries	7.1%
239	Stiff-Person Syndrome	7.1%
240	Restless Legs Syndrome	7%
241	Shy-Drager Syndrome	7%
242	Hyperlipoproteinemia Type III	7%
243	Neuronal Ceroid-Lipofuscinoses	6.9%
244	Diabetes Mellitus	6.8%
245	Lafora Disease	6.8%
246	Unverricht-Lundborg Syndrome	6.8%
247	Pituitary Diseases	6.7%
248	Dehydration	6.7%
249	Lipomatosis	6.7%
250	Werner Syndrome	6.7%
251	Toxoplasmosis, Cerebral	6.6%
252	Prion Diseases	6.6%
253	Achlorhydria	6.6%
254	Amino Acid Metabolism, Inborn Errors	6.6%
255	Bloom Syndrome	6.6%
256	Carbohydrate Metabolism, Inborn Errors	6.6%
257	Metal Metabolism, Inborn Errors	6.6%
258	Osteoporosis	6.6%
259	Progeria	6.6%
260	Lysosomal Storage Diseases	6.6%
261	Bone Demineralization, Pathologic	6.6%
262	Cytochrome-c Oxidase Deficiency	6.6%
263	Peroxisomal Disorders	6.6%
264	Post-Traumatic Osteoporosis	6.6%
265	Celiac Disease	6.6%
266	Sprue, Tropical	6.6%
267	Steatorrhea	6.6%
268	Sprue	6.6%
269	Hypoalphalipoproteinemias	6.6%
270	Renal tubular acidosis	6.6%
271	Carotid Artery Diseases	6.5%
272	Brain Ischemia	6.5%
273	Cerebrovascular accident	6.5%
274	Vasospasm, Intracranial	6.5%
275	Intracranial Arterial Diseases	6.5%
276	Brain Injuries, Diffuse	6.5%
277	Traumatic Brain Injury	6.5%
278	Cerebellar Ataxia	6.5%
279	Supratentorial Neoplasms	6.5%
280	Marasmus	6.4%
281	Vasculitis, Central Nervous System	6.3%
282	Persistent Vegetative State	6.3%
283	Cerebral Infarction	6.3%
284	Brain Stem Infarctions	6.3%
285	Ophthalmoplegic Migraine	6.2%
286	Moyamoya Disease	6.2%
287	Poliomyelitis	6.2%
288	Paraneoplastic Cerebellar Degeneration	6.2%
289	Spinal Muscular Atrophy	6.2%
290	Progressive Muscular Atrophy	6.2%
291	Meningitis, Bacterial	6.2%
292	Meningitis, Fungal	6.2%
293	Miller Fisher Syndrome	6.1%
294	Encephalomyelitis, Acute Disseminated	6%
295	HIV-Associated Lipodystrophy Syndrome	6%
296	Spinal Cord Injuries	6%
297	Auditory Perceptual Disorders	5.9%
298	Kwashiorkor	5.9%
299	Nesidioblastosis	5.9%
300	AIDS Dementia Complex	5.9%
301	Asterixis	5.8%
302	Ballismus	5.8%
303	Glycosuria	5.8%
304	Kearns-Sayre syndrome	5.8%
305	Separation Anxiety Disorder	5.7%
306	Intracranial Embolism and Thrombosis	5.7%
307	Post-Traumatic Headache	5.7%
308	Tension Headache	5.7%
309	Epilepsy, Complex Partial	5.7%
310	Migraine Disorders	5.7%
311	Abdominal Migraine	5.7%
312	Status Migrainosus	5.7%
313	Cervicogenic Headache	5.7%
314	Anxiety Disorders	5.7%
315	Avoidant Personality Disorder	5.7%
316	Dissociative disorder	5.7%
317	Drug toxicity	5.7%
318	Frigidity	5.7%
319	Hypoactive Sexual Desire Disorder	5.7%
320	Disruptive, Impulse Control, and Conduct Disorders	5.7%
321	Intermittent Explosive Disorder	5.7%
322	Kleptomania	5.7%
323	Narcissistic Personality Disorder	5.7%
324	Personality Disorders	5.7%
325	Poisoning	5.7%
326	Sexual Aversion Disorder	5.7%
327	Somatoform Disorder	5.7%
328	Dissociation	5.7%
329	Motor Disorders	5.7%
330	Mood Disorders	5.7%
331	Schizophrenia Spectrum and Other Psychotic Disorders	5.7%
332	Neurodevelopmental Disorders	5.7%
333	Nutrition Disorders	5.7%
334	Neurocognitive Disorders	5.7%
335	Feeding and Eating Disorders	5.7%
336	Scurvy	5.6%
337	Lateral Medullary Syndrome	5.6%
338	Acidosis, Lactic	5.5%
339	Calciphylaxis	5.5%
340	Hemosiderosis	5.5%
341	Ketosis	5.5%
342	Ketonuria	5.5%
343	Ketoacidosis	5.5%
344	Ketonemia	5.5%
345	Vascular calcification	5.5%
346	Glycosuria, Renal	5.5%
347	Tetany	5.4%
348	Chronic Fatigue Syndrome	5.3%
349	Myelitis, Transverse	5.3%
350	Parasomnia	5.3%
351	Dyssomnias	5.3%
352	Mucopolysaccharidosis III	5.2%
353	Subarachnoid Hemorrhage, Traumatic	5.2%
354	Carotid Artery, Internal, Dissection	5.2%
355	Porphyrias, Hepatic	5.2%
356	Pick Disease of the Brain	5.2%
357	Necrobiosis Lipoidica Diabeticorum	5.2%
358	Cockayne Syndrome	5.1%
359	Fanconi Anemia	5.1%
360	Cranial nerve diseases	5.1%
361	Demyelinating Diseases	5.1%
362	Demyelination	5.1%
363	Neuromuscular Diseases	5.1%
364	Chronobiology Disorders	5.1%
365	Chemical and Drug Induced Liver Injury	5.1%
366	Empty Sella Syndrome	4.9%
367	Hyperpituitarism	4.9%
368	Hypopituitarism	4.9%
369	Hypophysitis	4.9%
370	Arachnoiditis	4.9%
371	Aseptic Meningitis	4.9%
372	Syringomyelia	4.9%
373	Essential Tremor	4.9%
374	Familial Tremor	4.9%
375	Pneumorrhachis	4.9%
376	Writer's Cramp	4.9%
377	Spinal Cord Neoplasms	4.9%
378	Cerebral Arterial Diseases	4.9%
379	Vertebrobasilar Insufficiency	4.9%
380	Basilar Artery Stenosis	4.9%
381	Vertebral Artery Stenosis	4.9%
382	Intracranial Hemorrhage, Hypertensive	4.9%
383	Transient Cerebral Ischemia	4.9%
384	Subacute Sclerosing Panencephalitis	4.9%
385	Diffuse Axonal Injury	4.9%
386	Brain Stem Neoplasms	4.8%
387	Tuberculosis, Meningeal	4.8%
388	Familial Periodic Paralysis	4.8%
389	Motor Neuron Disease	4.8%
390	Optic Atrophy, Hereditary, Leber	4.8%
391	Cluster Headache	4.7%
392	Migraine with Aura	4.7%
393	Familial Hemiplegic Migraine	4.7%
394	Chronic Paroxysmal Hemicrania	4.7%
395	SUNCT Syndrome	4.7%
396	Paroxysmal Hemicrania	4.7%
397	Acidosis, Respiratory	4.7%
398	Adiposis Dolorosa	4.7%
399	Alkalosis, Respiratory	4.7%
400	Alkaptonuria	4.7%
401	Glycogen Storage Disease	4.7%
402	Hypophosphatasia	4.7%
403	Insulin Resistance	4.7%
404	Osteoporosis, Postmenopausal	4.7%
405	Propionic acidemia	4.7%
406	Dihydropyrimidine Dehydrogenase Deficiency	4.7%
407	Cystinosis	4.7%
408	Opsoclonus-Myoclonus Syndrome	4.7%
409	Metabolic Diseases	4.6%
410	Sleep Disorders, Circadian Rhythm	4.5%
411	Trauma, Nervous System	4.5%
412	Polyradiculoneuropathy	4.4%
413	Polyradiculoneuritis	4.4%
414	Botulism	4.4%
415	Hypercholesterolemia	4.4%
416	Hyperlipoproteinemias	4.4%
417	Hypertriglyceridemia	4.4%
418	Vertebral Artery Dissection	4.4%
419	Mucopolysaccharidosis II	4.4%
420	Nervous System Neoplasms	4.4%
421	Neurologic Manifestations	4.4%
422	Brain Contusion	4.3%
423	Carotid Stenosis	4.3%
424	Intracranial Aneurysm	4.3%
425	Arsenic Poisoning	4.3%
426	Central Nervous System Fungal Infections	4.3%
427	Conus Medullaris Syndrome	4.3%
428	Spinal Cord Vascular Diseases	4.3%
429	Intracranial Arteriosclerosis	4.3%
430	Cerebral Atherosclerosis	4.3%
431	Subarachnoid Hemorrhage	4.3%
432	Cerebral Arteriosclerosis	4.3%
433	Cerebral Hemorrhage	4.3%
434	Cerebral Thrombosis	4.3%
435	Intracranial Embolism	4.3%
436	Intracranial Thrombosis	4.3%
437	Sjogren-Larsson Syndrome	4.2%
438	Gestational Diabetes	4.2%
439	Latent Autoimmune Diabetes in Adults	4.2%
440	Diabetes Mellitus, Experimental	4.2%
441	Nephrocalcinosis	4.1%
442	Brain Concussion	4.1%
443	Hyperprolactinemia	4.1%
444	Subclavian Steal Syndrome	4%
445	Choroid Plexus Papilloma	4%
446	West Nile Fever	3.8%
447	Meningitis, Cryptococcal	3.8%
448	Autonomic Dysreflexia	3.8%
449	Complex Regional Pain Syndromes	3.8%
450	Meningitis, Listeria	3.8%
451	Carotid Artery Thrombosis	3.8%
452	Meningitis, Haemophilus	3.8%
453	Meningitis, Pneumococcal	3.8%
454	Central Nervous System Bacterial Infections	3.8%
455	Glycogen Storage Disease Type I	3.8%
456	Glycogen Storage Disease Type V	3.8%
457	Mushroom Poisoning	3.8%
458	Alice in Wonderland Syndrome	3.8%
459	Obesity	3.7%
460	Scrapie	3.7%
461	Central Cord Syndrome	3.7%
462	Primary amyloidosis	3.7%
463	Chorea	3.7%
464	Variegate Porphyria	3.7%
465	Acute intermittent porphyria	3.7%
466	Porphyria Cutanea Tarda	3.7%
467	Giant Cell Arteritis	3.7%
468	Temporal Arteritis	3.7%
469	Hypokalemic periodic paralysis	3.7%
470	Renal Aminoacidurias	3.7%
471	Fanconi Syndrome	3.7%
472	Pseudohypoaldosteronism	3.7%
473	Liddle Syndrome	3.7%
474	Xeroderma Pigmentosum	3.6%
475	Acromegaly	3.6%
476	Sinus Thrombosis, Intracranial	3.5%
477	Guillain-Barre Syndrome	3.4%
478	Peripheral Nerve Injuries	3.3%
479	Gout	3.3%
480	Consciousness Disorders	3.3%
481	Mental Retardation	3.3%
482	Depressed Level of Consciousness	3.3%
483	Mental deficiency	3.3%
484	Intellectual Disability	3.3%
485	Myasthenia Gravis	3.3%
486	Adjustment Disorders	3.3%
487	Affective Disorders, Psychotic	3.3%
488	Agoraphobia	3.3%
489	Anorexia Nervosa	3.3%
490	Antisocial Personality Disorder	3.3%
491	Bipolar Disorder	3.3%
492	Body Dysmorphic Disorders	3.3%
493	Borderline Personality Disorder	3.3%
494	Capgras Syndrome	3.3%
495	Child Behavior Disorders	3.3%
496	Developmental Disabilities	3.3%
497	Child Development Disorders, Pervasive	3.3%
498	Claustrophobia	3.3%
499	Cognition Disorders	3.3%
500	Conversion disorder	3.3%
501	Cyclothymic Disorder	3.3%
502	Dependent Personality Disorder	3.3%
503	Depressive disorder	3.3%
504	Developmental Coordination Disorder	3.3%
505	Exhibitionism	3.3%
506	Factitious Disorders	3.3%
507	Firesetting Behavior	3.3%
508	Fluoride Poisoning	3.3%
509	Food Poisoning	3.3%
510	Gas Poisoning	3.3%
511	Head Banging	3.3%
512	Histrionic Personality Disorder	3.3%
513	Hypochondriasis	3.3%
514	Masochism	3.3%
515	Melancholia	3.3%
516	Motor Skills Disorders	3.3%
517	Dissociative Identity Disorder	3.3%
518	Mycotoxicosis	3.3%
519	Neurasthenia	3.3%
520	Obsessive-Compulsive Disorder	3.3%
521	Oppositional Defiant Disorder	3.3%
522	Panic Disorder	3.3%
523	Paranoid Personality Disorder	3.3%
524	Pedophilia	3.3%
525	Plant Poisoning	3.3%
526	Pseudodementia	3.3%
527	Psychotic Disorders	3.3%
528	Sadism	3.3%
529	Schizoaffective Disorder	3.3%
530	Schizoid Personality Disorder	3.3%
531	Schizophrenia	3.3%
532	Schizophrenia, Childhood	3.3%
533	Schizotypal Personality Disorder	3.3%
534	Stereotypic Movement Disorder	3.3%
535	Transvestism	3.3%
536	Trichotillomania	3.3%
537	Voyeurism	3.3%
538	Anticholinergic Syndrome	3.3%
539	Malnutrition	3.3%
540	Attention Deficit and Disruptive Behavior Disorders	3.3%
541	Hyperkinetic Heart Syndrome	3.3%
542	Reactive Attachment Disorder	3.3%
543	Sexual and Gender Disorders	3.3%
544	Gender Dysphoria	3.3%
545	Serotonin Syndrome	3.3%
546	Organophosphate poisoning	3.3%
547	Propofol Infusion Syndrome	3.3%
548	Paranoia	3.3%
549	Compulsive Personality Disorder	3.3%
550	Bulimia Nervosa	3.3%
551	Lambert-Eaton Myasthenic Syndrome	3.3%
552	Jet Lag Syndrome	3.3%
553	Antley-Bixler Syndrome Phenotype	3.3%
554	Chemical and Drug Induced Liver Injury, Chronic	3.3%
555	Sleep Talking	3.3%
556	Manganese Poisoning	3.3%
557	Sleep Disorders, Intrinsic	3.3%
558	Torticollis	3.2%
559	Cavernous Sinus Thrombosis	3.2%
560	Sagittal Sinus Thrombosis	3.2%
561	Hematoma, Subdural	3.2%
562	Hematoma, Epidural, Cranial	3.2%
563	Acrodynia	3.1%
564	Neuromyelitis Optica	3%
565	CREST Syndrome	3%
566	Mutism	3%
567	Selective Mutism	3%
568	Central Nervous System Cysts	2.9%
569	Bites and Stings	2.9%
570	Amnesia	2.9%
571	Delirium	2.9%
572	Dissociative Amnesia	2.9%
573	Global Amnesia	2.9%
574	Cystinuria	2.9%
575	Olfactory Nerve Injuries	2.9%
576	Sleep Bruxism	2.9%
577	Metabolic Side Effects of Drugs and Substances	2.9%
578	Causalgia	2.9%
579	Prolactinoma	2.9%
580	Growth Hormone-Secreting Pituitary Adenoma	2.9%
581	Gambling	2.8%
582	Premature Ejaculation	2.8%
583	Injection Site Reaction	2.8%
584	Erectile dysfunction	2.8%
585	Infusion site reaction	2.8%
586	Nelson Syndrome	2.8%
587	Progressive bulbar palsy	2.8%
588	Bulbar palsy	2.8%
589	Mercury Poisoning, Nervous System	2.8%
590	Lead Poisoning, Nervous System	2.8%
591	Spinal Cord Ischemia	2.8%
592	Tuberculosis, Central Nervous System	2.8%
593	Albinism	2.8%
594	Dysautonomia	2.8%
595	Vagus Nerve Disorder	2.8%
596	Glossopharyngeal Neuralgia	2.8%
597	Abducens Nerve Diseases	2.8%
598	Heavy Metal Poisoning, Nervous System	2.8%
599	Neuromuscular Junction Diseases	2.8%
600	Tauopathies	2.8%
601	Trochlear Nerve Diseases	2.8%
602	Peripheral Nervous System Diseases	2.8%
603	Prader-Willi Syndrome	2.7%
604	Hematoma, Subdural, Intracranial	2.7%
605	Hematoma, Subdural, Chronic	2.7%
606	Hematoma, Subdural, Acute	2.7%
607	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.7%
608	Arthritis, Gouty	2.6%
609	Tardive Dyskinesia	2.6%
610	Facial Nerve Injuries	2.6%
611	Obesity, Abdominal	2.6%
612	Horner Syndrome	2.6%
613	Sleep Deprivation	2.6%
614	Dyspareunia	2.5%
615	Multiple Sclerosis	2.5%
616	Neuroaspergillosis	2.5%
617	Myopathy	2.4%
618	Optic Neuropathy	2.4%
619	Tuberous Sclerosis	2.4%
620	Facial Nerve Diseases	2.4%
621	Craniocerebral Trauma	2.4%
622	Myasthenia Gravis, Autoimmune, Experimental	2.4%
623	Vestibulocochlear Nerve Diseases	2.4%
624	Decerebrate State	2.4%
625	Hemiparesis	2.4%
626	Hydranencephaly	2.4%
627	Meningism	2.4%
628	Neural Tube Defects	2.4%
629	Paresis	2.4%
630	Seizures	2.4%
631	Sensation Disorders	2.4%
632	Tethered Cord Syndrome	2.4%
633	Central Nervous System Neoplasms	2.4%
634	Complex partial seizures	2.4%
635	Iniencephaly	2.4%
636	Craniorachischisis	2.4%
637	Exencephaly	2.4%
638	Monoparesis	2.4%
639	Septo-Optic Dysplasia	2.4%
640	Cortical Dysplasia	2.4%
641	Neurogenic Inflammation	2.4%
642	Gait Disorders, Neurologic	2.4%
643	Neuromuscular Manifestations	2.4%
644	Malformations of Cortical Development	2.4%
645	Ichthyosis, X-Linked	2.4%
646	Sweating, Gustatory	2.4%
647	Auriculotemporal Syndrome	2.4%
648	Reflex Sympathetic Dystrophy	2.3%
649	Nocturnal Myoclonus Syndrome	2.3%
650	Disorders of Excessive Somnolence	2.3%
651	Sleep Initiation and Maintenance Disorders	2.3%
652	Night Terrors	2.3%
653	Somnambulism	2.3%
654	Transient Insomnia	2.3%
655	Sleep Paralysis	2.3%
656	Chronic Insomnia	2.3%
657	REM Sleep Behavior Disorder	2.3%
658	Hypersomnia	2.3%
659	Pediatric Obesity	2.3%
660	Alexia	2.3%
661	Dyslexia	2.3%
662	Pseudorabies	2.3%
663	Cardiotoxicity	2.2%
664	Dyscalculia	2.2%
665	Enuresis	2.2%
666	Ophthalmoplegia	2.2%
667	External Ophthalmoplegia	2.2%
668	Cadmium poisoning	2.2%
669	Carbon Monoxide Poisoning	2.2%
670	Ciguatera Poisoning	2.2%
671	Combat Disorders	2.2%
672	Deficiency Diseases	2.2%
673	Dysthymic Disorder	2.2%
674	Ergotism	2.2%
675	Hysteria	2.2%
676	Lead Poisoning	2.2%
677	Mercury Poisoning	2.2%
678	Schizophrenia, Catatonic	2.2%
679	Schizophrenia, Disorganized	2.2%
680	Post-Traumatic Stress Disorder	2.2%
681	Attention Deficit Disorder	2.2%
682	Seasonal Affective Disorder	2.2%
683	Conduct Disorder	2.2%
684	Social Communication Disorder	2.2%
685	Shellfish Poisoning	2.2%
686	Psychological Trauma	2.2%
687	Hoarding Disorder	2.2%
688	Phonological Disorder	2.2%
689	Neurosyphilis	2.2%
690	Pupil Disorders	2.1%
691	Neurobehavioral Manifestations	2.1%
692	Charcot-Marie-Tooth Disease	2.1%
693	Paraneoplastic Encephalomyelitis	2.1%
694	Anterior Spinal Artery Syndrome	2.1%
695	Lead Poisoning, Nervous System, Childhood	2.1%
696	Lead Poisoning, Nervous System, Adult	2.1%
697	Alexia, Pure	2.1%
698	Uveomeningoencephalitic Syndrome	2.1%
699	Sturge-Weber Syndrome	2.1%
700	Vertigo	2.1%
701	Vocal Cord Paralysis	2%
702	Retrograde amnesia	2%
703	Amnesia, Anterograde	2%
704	Brain Diseases, Metabolic	2%
705	Lyme Neuroborreliosis	1.9%
706	Waterhouse-Friderichsen Syndrome	1.9%
707	Insect Bites and Stings	1.9%
708	Argyria	1.9%
709	Depression, Postpartum	1.9%
710	Voice Disorders	1.9%
711	Voice Disturbance	1.9%
712	Premenstrual Dysphoric Disorder	1.9%
713	Salmonella food poisoning	1.9%
714	Brachial Plexus Neuritis	1.9%
715	Neuralgic Amyotrophy	1.9%
716	Narcolepsy	1.9%
717	Kleine-Levin Syndrome	1.9%
718	Toxoplasmosis, Congenital	1.8%
719	Smith-Magenis syndrome	1.8%
720	Malaria, Cerebral	1.8%
721	Dural Arteriovenous Fistula	1.8%
722	Neurocysticercosis	1.8%
723	Myotonia Congenita	1.8%
724	Cerebrospinal Fluid Otorrhea	1.8%
725	Cerebrospinal Fluid Rhinorrhea	1.8%
726	Neuritis, Autoimmune, Experimental	1.8%
727	Gait Ataxia	1.8%
728	Myotonic Dystrophy	1.8%
729	Coma, Post-Head Injury	1.7%
730	Drug Eruptions	1.6%
731	Reflex, Abnormal	1.6%
732	Hyporeflexia	1.6%
733	Hyperreflexia	1.6%
734	Neuritis	1.6%
735	Polyneuritis	1.6%
736	Radiculitis	1.6%
737	Polyneuropathy	1.6%
738	Mononeuritis	1.6%
739	Mononeuropathies	1.6%
740	Brachial Plexus Neuropathies	1.6%
741	Radiculopathy	1.6%
742	Mononeuropathy Multiplex	1.6%
743	Nerve Root Compression	1.6%
744	Akathisia	1.6%
745	Restlessness	1.6%
746	Psychomotor Agitation	1.6%
747	Autistic Disorder	1.6%
748	Asperger Syndrome	1.6%
749	Avitaminosis	1.6%
750	Tarsal Tunnel Syndrome	1.6%
751	Cauda Equina Syndrome	1.6%
752	Multiple Sclerosis, Chronic Progressive	1.6%
753	Multiple Sclerosis, Relapsing-Remitting	1.6%
754	Cataplexy	1.6%
755	Optic Nerve Glioma	1.6%
756	Alstrom Syndrome	1.5%
757	Gait Apraxia	1.5%
758	Diurnal Enuresis	1.4%
759	Carpal Tunnel Syndrome	1.4%
760	Myositis	1.4%
761	Optic Atrophy	1.4%
762	Optic Neuritis	1.4%
763	Papilledema	1.4%
764	Strabismus	1.4%
765	Tolosa-Hunt Syndrome	1.4%
766	Isaacs syndrome	1.4%
767	Myotonic Disorders	1.4%
768	Myasthenic Syndromes, Congenital	1.4%
769	neurofibroma	1.4%
770	Sciatica	1.4%
771	Diabetic Neuropathies	1.4%
772	Facial Injuries	1.4%
773	Facial Neuralgia	1.4%
774	Diabetic Amyotrophy	1.4%
775	Diabetic Autonomic Neuropathy	1.4%
776	Orthostatic intolerance	1.4%
777	Anosmia	1.4%
778	Ataxia	1.4%
779	Athetosis	1.4%
780	Catalepsy	1.4%
781	Dystonia	1.4%
782	Hemiplegia	1.4%
783	Locked-In Syndrome	1.4%
784	Meningeal Neoplasms	1.4%
785	Meningomyelocele	1.4%
786	Muscle Hypertonia	1.4%
787	Muscle hypotonia	1.4%
788	Myoclonus	1.4%
789	Myotonia	1.4%
790	Neuralgia	1.4%
791	Paraplegia	1.4%
792	Pseudobulbar Palsy	1.4%
793	Quadriplegia	1.4%
794	Spasm	1.4%
795	Spastic Paraplegia	1.4%
796	Status Epilepticus	1.4%
797	Taste Disorders	1.4%
798	Tremor	1.4%
799	Spina Bifida	1.4%
800	Monoplegia	1.4%
801	Hypokinesia	1.4%
802	Paraparesis	1.4%
803	Bradykinesia	1.4%
804	Waxy flexibility	1.4%
805	Action Tremor	1.4%
806	Resting Tremor	1.4%
807	Dysosmia	1.4%
808	Quadriparesis	1.4%
809	Olfaction Disorders	1.4%
810	Myokymia	1.4%
811	Vestibular Neuronitis	1.4%
812	Somatosensory Disorders	1.4%
813	Neuropathic pain	1.4%
814	Hyperkinesia	1.4%
815	Intention tremor	1.4%
816	Acoustic Neuroma	1.4%
817	Wernicke Encephalopathy	1.4%
818	Tick Paralysis	1.4%
819	Asthma, Aspirin-Induced	1.3%
820	Hand-Arm Vibration Syndrome	1.3%
821	Vision Disorders	1.3%
822	Metamorphopsia	1.3%
823	Visual Impairment	1.3%
824	Fibromyalgia	1.3%
825	Optic Neuropathy, Ischemic	1.3%
826	Anterior Ischemic Optic Neuropathy	1.3%
827	Medial Tibial Stress Syndrome	1.3%
828	Facial Hemiatrophy	1.2%
829	Melkersson-Rosenthal Syndrome	1.2%
830	Anisocoria	1.2%
831	Confusion	1.2%
832	Facial paralysis	1.2%
833	Lethargy	1.2%
834	Memory Disorders	1.2%
835	Muscle Cramp	1.2%
836	Perceptual Disorders	1.2%
837	Psychomotor Disorders	1.2%
838	Tonic Pupil	1.2%
839	Eosinophilia-Myalgia Syndrome	1.2%
840	Anhedonia	1.2%
841	Disorientation	1.2%
842	Facial Paresis	1.2%
843	Memory Loss	1.2%
844	Hemisensory Neglect	1.2%
845	Dysacusis	1.2%
846	Anencephaly	1.2%
847	Meningocele	1.2%
848	Muscular Atrophy	1.2%
849	Respiratory Paralysis	1.2%
850	Encephalocele	1.2%
851	Acute Generalized Exanthematous Pustulosis	1.2%
852	Thiamine Deficiency	1.2%
853	Cubital Tunnel Syndrome	1.2%
854	Classical Lissencephalies and Subcortical Band Heterotopias	1.1%
855	Duane Retraction Syndrome	1.1%
856	Muscle Weakness	1.1%
857	Mobius Syndrome	1.1%
858	Bell Palsy	1.1%
859	Catatonia	1.1%
860	Herpes Zoster Oticus	1.1%
861	Aphonia	1.1%
862	Dysphonia	1.1%
863	Sciatic Neuropathy	1.1%
864	Ulnar Neuropathies	1.1%
865	Lesion of Sciatic Nerve	1.1%
866	Ulnar Neuritis	1.1%
867	Radial nerve compression	1.1%
868	Radial Tunnel Syndrome	1.1%
869	Peroneal Neuropathies	1.1%
870	Radial Neuropathy	1.1%
871	Median Neuropathy	1.1%
872	Sciatic Nerve Palsy	1.1%
873	Femoral Neuropathy	1.1%
874	Tibial Neuropathy	1.1%
875	Ulnar Nerve Palsy	1.1%
876	Postural Orthostatic Tachycardia Syndrome	1.1%
877	Radial nerve palsy	1.1%
878	Erythema Nodosum	1.1%
879	Serum Sickness	1.1%
880	Myalgia	1%
881	Thoracic Outlet Syndrome	0.9%
882	Esotropia	0.9%
883	Exotropia	0.9%
884	Hypotension, Orthostatic	0.9%
885	Sleep Apnea Syndromes	0.9%
886	Polymyositis	0.9%
887	Post-Exercise Hypotension	0.9%
888	Trigeminal Nerve Disorder	0.9%
889	Dermal Sinus	0.9%
890	Dysgeusia	0.9%
891	Formication	0.9%
892	Hyperalgesia	0.9%
893	Hyperesthesia	0.9%
894	Hypesthesia	0.9%
895	Language Disorders	0.9%
896	Numbness	0.9%
897	Paresthesia	0.9%
898	Paraparesis, Spastic	0.9%
899	Spina Bifida Cystica	0.9%
900	Trismus	0.9%
901	Spina Bifida Occulta	0.9%
902	Epilepsia Partialis Continua	0.9%
903	Hypogeusia	0.9%
904	Meningeal Carcinomatosis	0.9%
905	Brown-Sequard Syndrome	0.9%
906	Lissencephaly	0.9%
907	Polymicrogyria	0.9%
908	Pachygyria	0.9%
909	Schizencephaly	0.9%
910	Lockjaw	0.9%
911	Allodynia	0.9%
912	Periventricular Nodular Heterotopia	0.9%
913	Ageusia	0.9%
914	Aicardi's syndrome	0.9%
915	Hoarseness	0.9%
916	Toxic Epidermal Necrolysis	0.9%
917	Stevens-Johnson Syndrome	0.9%
918	Neurofibrosarcoma	0.9%
919	Eye Injuries	0.8%
920	Muscular Dystrophy	0.8%
921	Congenital nystagmus	0.8%
922	Orbital Myositis	0.8%
923	Holoprosencephaly	0.8%
924	Diplopia	0.8%
925	Muscle Rigidity	0.8%
926	Muscle Spasticity	0.8%
927	Scotoma	0.8%
928	Photophobia	0.8%
929	Cogwheel Rigidity	0.8%
930	Hemifacial Spasm	0.8%
931	Amaurosis	0.8%
932	Blindness	0.8%
933	Nuchal Rigidity	0.8%
934	Pyomyositis	0.8%
935	Agnosia	0.8%
936	Apraxias	0.8%
937	Hallucinations	0.8%
938	Hemianopsia	0.8%
939	Hyperacusis	0.8%
940	Tinnitus	0.8%
941	Visual Agnosia	0.8%
942	Anosognosia	0.8%
943	Wernicke-Korsakoff Syndrome	0.8%
944	Phonophobia	0.8%
945	Hearing Loss	0.8%
946	Polyradiculopathy	0.8%
947	Sarcopenia	0.8%
948	Color blindness	0.7%
949	Cri-du-Chat Syndrome	0.7%
950	Down Syndrome	0.7%
951	Trisomy 21	0.7%
952	POEMS Syndrome	0.7%
953	Meningioma	0.7%
954	Williams Syndrome	0.7%
955	Microcephaly	0.7%
956	Macrocephaly	0.7%
957	Porencephaly	0.7%
958	Sleep Apnea, Obstructive	0.7%
959	Sleep Apnea, Central	0.7%
960	Trigeminal Neuralgia	0.7%
961	Agraphia	0.7%
962	Anomia	0.7%
963	Cluttering	0.7%
964	Language Development Disorders	0.7%
965	Speech Disorders	0.7%
966	Syncope	0.7%
967	Stupor	0.7%
968	Dysgraphia	0.7%
969	Presyncope	0.7%
970	Dyslalia	0.7%
971	Phantom pain	0.6%
972	Phantom Limb Pain	0.6%
973	Eye Burns	0.6%
974	Welander Distal Myopathy	0.6%
975	Amaurosis Fugax	0.6%
976	Blindness, Cortical	0.6%
977	Rett Syndrome	0.6%
978	Deafness	0.6%
979	Hearing Loss, Sudden	0.6%
980	Gerstmann Syndrome	0.6%
981	Hearing Loss, Bilateral	0.6%
982	Hearing Loss, High-Frequency	0.6%
983	Hearing Loss, Mixed Conductive-Sensorineural	0.6%
984	Prosopagnosia	0.6%
985	Apraxia, Ideomotor	0.6%
986	Charles Bonnet Syndrome	0.6%
987	Hearing Loss, Unilateral	0.6%
988	Complete Hearing Loss	0.6%
989	Alien Hand Syndrome	0.6%
990	Deaf Mutism	0.6%
991	Aphasia	0.6%
992	Articulation Disorders	0.6%
993	Echolalia	0.6%
994	Stuttering	0.6%
995	Dysphasia	0.6%
996	Dermatomyositis	0.6%
997	Corneal Scar	0.6%
998	Rubinstein-Taybi Syndrome	0.5%
999	Muscular Dystrophy, Duchenne	0.5%
1000	Dysarthria	0.5%
1001	Fragile X Syndrome	0.5%
1002	Corneal Perforation	0.5%

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