MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cavernous Sinus Thrombosis

(UMLS:C0238454)

Definition:: Formation or presence of a blood clot (THROMBUS) in the CAVERNOUS SINUS of the brain. Infections of the paranasal sinuses and adjacent structures, CRANIOCEREBRAL TRAUMA, and THROMBOPHILIA are associated conditions. Clinical manifestations include dysfunction of cranial nerves III, IV, V, and VI, marked periorbital swelling, chemosis, fever, and visual loss. (From Adams et al., Principles of Neurology, 6th ed, p711)
UMLS ID:: C0238454
MeSH ID:: D020226

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.300.525.425.500.375

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.253.566.350.500.375|C14.907.355.590.213.350.500.375

Synonym(s)

Cavernous Sinus Thrombosis

Cavernous sinus thrombosis

Cerebral venous thrombosis of cavernous sinus

Thrombosis of cavernous venous sinus

cavernous sinus thrombosis

cavernous; thrombosis

sinus cavernous thrombosis

thrombosis cavernous sinus

thrombosis of cavernous sinus

10.

thrombosis; cavernous

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	NuvaRing	FAERS: 15		OFFSIDES US FAERS
2	Cabergoline	FAERS: 4		US FAERS
3	Norgestrel	FAERS: 4		US FAERS
4	Tacrolimus	FAERS: 3		US FAERS
5	Tadalafil	FAERS: 3		US FAERS
6	Junel 1/20	FAERS: 2		US FAERS
7	Albuterol	FAERS: 1		US FAERS
8	Deferasirox	FAERS: 1		OFFSIDES US FAERS
9	Fingolimod Hydrochloride	FAERS: 1		US FAERS
10	Medroxyprogesterone Acetate	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
11	Mycophenolic Acid	FAERS: 1		US FAERS
12	Ortho Evra	FAERS: 1		US FAERS
13	Risperidone	FAERS: 1		US FAERS
14	Thyroxine	FAERS: 1		US FAERS
15	Thyroxine	FAERS: 1		US FAERS
16	Vancomycin	FAERS: 1		US FAERS
17	dorzolamide	FAERS: 1		US FAERS
18	lenvatinib	FAERS: 1		US FAERS
19	reviparin	FAERS: 1		US FAERS
20	Bosentan			OFFSIDES
21	Clozapine			OFFSIDES
22	Cyclophosphamide		10713653	CTD
23	Cytarabine			OFFSIDES
24	Leflunomide			OFFSIDES
25	Linezolid		18380704	CTD
26	Mercaptopurine			OFFSIDES
27	Methyldopa			OFFSIDES
28	Methyltestosterone			OFFSIDES
29	Octreotide			OFFSIDES
30	Oxytocin			OFFSIDES
31	Piperacillin, Tazobactam Drug Combination			OFFSIDES
32	Rifampin		18380704	CTD
33	Tobramycin			OFFSIDES
34	Trimethoprim, Sulfamethoxazole Drug Combination		18380704	CTD
35	Vancomycin		18380704 20644319	CTD
36	fludarabine phosphate			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Sagittal Sinus Thrombosis	50.9%
2	Intracranial Embolism	33.3%
3	Carotid Artery Thrombosis	29.6%
4	Basal Ganglia Cerebrovascular Disease	25%
5	Carotid Artery Diseases	24.9%
6	Brain Ischemia	24.9%
7	Cerebrovascular accident	24.9%
8	Vasospasm, Intracranial	24.9%
9	Intracranial Arterial Diseases	24.9%
10	Vascular Headaches	23.1%
11	Vasculitis, Central Nervous System	23%
12	Myocardial Ischemia	22.1%
13	Leukomalacia, Periventricular	21.6%
14	Spinal Cord Vascular Diseases	20.5%
15	Aneurysm	20.3%
16	Angiomatosis	20.3%
17	Aortic Diseases	20.3%
18	Arterial Occlusive Diseases	20.3%
19	Hyperemia	20.3%
20	Hypotension	20.3%
21	Superior Vena Cava Syndrome	20.3%
22	Telangiectasis	20.3%
23	Vasculitis	20.3%
24	Venous Insufficiency	20.3%
25	Peripheral Vascular Diseases	20.3%
26	Angiodysplasia	20.3%
27	Capillary Leak Syndrome	20.3%
28	Prehypertension	20.3%
29	Brain Infarction	19.5%
30	Moyamoya Disease	18.9%
31	Carotid Stenosis	18.4%
32	Intracranial Aneurysm	18.4%
33	Retinal Vein Occlusion	17.3%
34	Embolism	17.2%
35	Thrombosis	17.2%
36	Embolus	17.2%
37	Vascular System Injuries	17%
38	Thoracic Outlet Syndrome	17%
39	Aortic Aneurysm	16.9%
40	Aortitis	16.9%
41	Leriche Syndrome	16.9%
42	Periphlebitis	16.9%
43	Phlebitis	16.9%
44	Thromboangiitis Obliterans	16.9%
45	Compartment syndromes	16.6%
46	Hepatic Veno-Occlusive Disease	16.6%
47	Peliosis Hepatis	16.6%
48	Varicocele	16.6%
49	Diabetic Angiopathies	16.4%
50	Reperfusion Injury	16.4%
51	Splenic Infarction	16.4%
52	Vascular Neoplasms	16.4%
53	Vasoplegia	16.4%
54	Venous Thromboembolism	16.3%
55	Hemorrhoids	16.3%
56	Carotid Artery Injuries	16.1%
57	Dementia, Vascular	15.8%
58	Hypoxia-Ischemia, Brain	15.5%
59	Hand-Arm Vibration Syndrome	15.4%
60	Intracranial Arteriosclerosis	15.1%
61	Cerebral Atherosclerosis	15.1%
62	Cerebral Arteriosclerosis	15.1%
63	Optic Neuropathy, Ischemic	15%
64	Anterior Ischemic Optic Neuropathy	15%
65	Myocardial Reperfusion Injury	14.2%
66	Malignant Atrophic Papulosis	14.2%
67	Shwartzman Phenomenon	14.1%
68	Mesenteric vascular insufficiency	13.8%
69	Heart Diseases	13.7%
70	Cerebral Arterial Diseases	13.6%
71	Vertebrobasilar Insufficiency	13.6%
72	Basilar Artery Stenosis	13.6%
73	Vertebral Artery Stenosis	13.6%
74	Intracranial Hemorrhage, Hypertensive	13.6%
75	Transient Cerebral Ischemia	13.6%
76	Basal Ganglia Hemorrhage	13.6%
77	Angioedema	13.5%
78	Colitis, Ischemic	13.5%
79	Postphlebitic Syndrome	12.9%
80	Vertebral Artery Dissection	12.3%
81	Subarachnoid Hemorrhage, Traumatic	12.3%
82	Encephalomyelitis	12.2%
83	Giant Cell Arteritis	12.2%
84	Temporal Arteritis	12.2%
85	Coronary Aneurysm	12.1%
86	Pituitary Apoplexy	11.9%
87	Akinetic Mutism	11.9%
88	Anoxic Encephalopathy	11.9%
89	Basal Ganglia Diseases	11.9%
90	Brain Damage, Chronic	11.9%
91	Cerebellar Diseases	11.9%
92	Encephalitis	11.9%
93	Encephalomalacia	11.9%
94	Epilepsy	11.9%
95	Hydrocephalus	11.9%
96	Congenital Hydrocephalus	11.9%
97	Hypothalamic Diseases	11.9%
98	Thalamic Diseases	11.9%
99	Intracranial Hypertension	11.9%
100	Aura	11.9%
101	Leukoencephalopathy	11.9%
102	Neuroaxonal Dystrophies	11.9%
103	Headache Disorders	11.9%
104	Intracranial Hypotension	11.9%
105	Brain Edema	11.9%
106	Brain Hypoxia	11.9%
107	Aqueductal Stenosis	11.9%
108	Subdural Effusion	11.7%
109	Cerebral Infarction	11.5%
110	Brain Stem Infarctions	11.5%
111	Subarachnoid Hemorrhage	11.4%
112	Cerebral Hemorrhage	11.4%
113	Coronary heart disease	11.3%
114	Myocardial Infarction	11.3%
115	Acute Coronary Syndrome	11.3%
116	Coronary Thrombosis	11.2%
117	Pregnancy Complications, Cardiovascular	11.1%
118	Cardiovascular Abnormalities	11.1%
119	Arteriovenous fistula	11.1%
120	Thrombophlebitis	11%
121	Meningoencephalitis	11%
122	Blue Toe Syndrome	11%
123	Scimitar Syndrome	10.9%
124	Embolism, Amniotic Fluid	10.8%
125	Carotid Artery, Internal, Dissection	10.7%
126	Spinal Cord Ischemia	10.5%
127	Aneurysm, Dissecting	10.5%
128	Arteriosclerosis	10.5%
129	Arteritis	10.5%
130	Erythromelalgia	10.5%
131	Fibromuscular Dysplasia	10.5%
132	Malignant Hypertension	10.5%
133	Raynaud Disease	10.5%
134	Essential Hypertension	10.5%
135	Aneurysm, Ruptured	10.5%
136	Iliac Aneurysm	10.5%
137	Pulmonary artery stenosis	10.5%
138	White Coat Hypertension	10.5%
139	Systemic Vasculitis	10.5%
140	Embolism and Thrombosis	10.3%
141	Infarction, Middle Cerebral Artery	10.3%
142	Infarction, Anterior Cerebral Artery	10.3%
143	Infarction, Posterior Cerebral Artery	10.3%
144	Lupus Vasculitis, Central Nervous System	10.1%
145	Meningitis	10%
146	Movement Disorders	10%
147	Pachymeningitis	10%
148	Spinal Cord Diseases	10%
149	Brain Abscess	9.9%
150	Aortic Rupture	9.9%
151	Pneumocephalus	9.9%
152	Brain Diseases, Metabolic	9.7%
153	Dementia	9.7%
154	Shy-Drager Syndrome	9.7%
155	Multiple System Atrophy	9.6%
156	Kounis Syndrome	9.5%
157	Ocular Motility Disorders	9.4%
158	Cyclophoria	9.4%
159	May-Thurner Syndrome	9.4%
160	Angina Pectoris	9.4%
161	Sturge-Weber Syndrome	9.3%
162	Dandy-Walker Syndrome	9.2%
163	Air Embolism	9.2%
164	Venous Thrombosis	9.2%
165	Deep Vein Thrombosis	9.2%
166	Brain Injuries	9.2%
167	Brain Neoplasms	9.1%
168	Hypotension, Orthostatic	9.1%
169	Parkinsonian Disorders	9.1%
170	Post-Exercise Hypotension	9.1%
171	Aortic Aneurysm, Abdominal	9%
172	Aortic Aneurysm, Thoracic	9%
173	Coronary Artery Disease	8.8%
174	Retinal Artery Occlusion	8.6%
175	Retinal Vasculitis	8.6%
176	Hypertensive Retinopathy	8.6%
177	Anterior Compartment Syndrome	8.4%
178	Vasculitis, Leukocytoclastic, Cutaneous	8.4%
179	Gastric Antral Vascular Ectasia	8.4%
180	Abdominal Compartment Syndrome	8.4%
181	Central Nervous System Infection	8.4%
182	Varicose Ulcer	8.4%
183	Primary Graft Dysfunction	8.4%
184	Putaminal Hemorrhage	8.3%
185	Myelitis	8.2%
186	Brain Death	8.1%
187	Cerebrovascular Disorders	8.1%
188	Cerebrovascular Insufficiency	8.1%
189	Subclavian Steal Syndrome	8%
190	Lewy Body Disease	8%
191	Marchiafava-Bignami Disease	7.8%
192	Posterior Leukoencephalopathy Syndrome	7.8%
193	Posterior reversible encephalopathy syndrome	7.8%
194	Epilepsy, Post-Traumatic	7.7%
195	Polyarteritis Nodosa	7.6%
196	Takayasu Arteritis	7.6%
197	Pulmonary Embolism	7.5%
198	Lateral Medullary Syndrome	7.5%
199	Epidural Abscess	7.4%
200	Amblyopia	7.4%
201	Brain Hemorrhage, Traumatic	7.3%
202	CREST Syndrome	7.2%
203	Mesenteric Vascular Occlusion	7.2%
204	Mucocutaneous Lymph Node Syndrome	7.2%
205	Meige Syndrome	7.1%
206	Cerebral Ventriculitis	7.1%
207	Diabetic Retinopathy	7.1%
208	Livedo Reticularis	7.1%
209	MELAS Syndrome	7%
210	Renal hypertension	7%
211	Renal Artery Obstruction	7%
212	Renal Artery Stenosis	7%
213	Hemangioma, Cavernous	7%
214	Scurvy	7%
215	Stiff-Person Syndrome	6.9%
216	Prion Diseases	6.8%
217	Cranial nerve diseases	6.8%
218	Demyelinating Diseases	6.8%
219	Demyelination	6.8%
220	Neuromuscular Diseases	6.8%
221	Chronobiology Disorders	6.8%
222	Cardiac Tamponade	6.8%
223	Endocarditis	6.8%
224	Cardiac Arrest	6.8%
225	Heart failure	6.8%
226	Pericardial effusion	6.8%
227	Pericarditis	6.8%
228	Pneumopericardium	6.8%
229	Cor pulmonale	6.8%
230	Ventricular Outflow Obstruction	6.8%
231	Ventricular Dysfunction	6.8%
232	Cardiomyopathies	6.8%
233	Pleuropericarditis	6.8%
234	Cerebral Amyloid Angiopathy	6.7%
235	Ataxia Telangiectasia	6.7%
236	Neuroleptic Malignant Syndrome	6.5%
237	Myelinolysis, Central Pontine	6.5%
238	Huntington Disease	6.4%
239	Parkinson Disease	6.4%
240	Cerebral Palsy	6.2%
241	Epilepsies, Partial	6.2%
242	Epilepsy, Generalized	6.2%
243	Pseudotumor Cerebri	6.2%
244	Hypertensive Encephalopathy	6.2%
245	Simple Partial Seizures	6.2%
246	Epilepsy, Reflex	6.2%
247	Headache Disorders, Primary	6.2%
248	Headache Disorders, Secondary	6.2%
249	Medication overuse headache	6.2%
250	Amnesia, Transient Global	6.2%
251	Dystonia Musculorum Deformans	6.1%
252	Ischemic contracture	6.1%
253	Angioedemas, Hereditary	6.1%
254	Tricuspid Atresia	6.1%
255	Arrhythmogenic Right Ventricular Dysplasia	6.1%
256	Cryoglobulinemia	6%
257	Coronary Occlusion	6%
258	Microvascular Angina	6%
259	Coronary Stenosis	6%
260	ST segment elevation myocardial infarction	6%
261	Bacterial Endocarditis	6%
262	Subacute Combined Degeneration	6%
263	Progressive supranuclear palsy	6%
264	Creutzfeldt-Jakob disease	6%
265	Diabetic Foot	6%
266	Spinal Cord Injuries	5.9%
267	Cerebellar Neoplasms	5.8%
268	Spinal Muscular Atrophy	5.7%
269	Progressive Muscular Atrophy	5.7%
270	Asterixis	5.7%
271	Ballismus	5.7%
272	Anterior Spinal Artery Syndrome	5.7%
273	Trauma, Nervous System	5.7%
274	Arteriosclerosis Obliterans	5.6%
275	Atherosclerosis	5.6%
276	Endarteritis	5.6%
277	Aortic Valve Stenosis	5.6%
278	Cardiomyopathy, Dilated	5.6%
279	Pulmonary Valve Stenosis	5.6%
280	Cardiac Output, High	5.5%
281	Myocardial Stunning	5.5%
282	Low Cardiac Output Syndrome	5.5%
283	Myoclonic Epilepsy	5.5%
284	Epilepsy, Temporal Lobe	5.5%
285	Epilepsy, Rolandic	5.5%
286	Benign Rolandic Epilepsy	5.5%
287	Nervous System Neoplasms	5.5%
288	Neurologic Manifestations	5.5%
289	Neurotoxicity Syndromes	5.5%
290	Cardiomegaly	5.5%
291	Postpericardiotomy Syndrome	5.5%
292	Cardiac Hypertrophy	5.5%
293	Motor Neuron Disease	5.4%
294	Rheumatic Heart Disease	5.4%
295	Intracranial Embolism and Thrombosis	5.4%
296	Limbic Encephalitis	5.4%
297	Thromboembolism	5.4%
298	Presenile dementia	5.4%
299	Senile dementia	5.4%
300	Purpura, Hyperglobulinemic	5.3%
301	Pituitary Diseases	5.2%
302	Meningitis, Bacterial	5.2%
303	Meningitis, Fungal	5.2%
304	Amyotrophic Lateral Sclerosis	5.2%
305	Chronic Fatigue Syndrome	5.1%
306	Arachnoiditis	5.1%
307	Aseptic Meningitis	5.1%
308	Syringomyelia	5.1%
309	Essential Tremor	5.1%
310	Familial Tremor	5.1%
311	Pneumorrhachis	5.1%
312	Writer's Cramp	5.1%
313	Shock, Cardiogenic	5.1%
314	Kluver-Bucy Syndrome	5%
315	Leukoencephalopathy, Progressive Multifocal	5%
316	Poliomyelitis	5%
317	Striatonigral Degeneration	5%
318	Angina, Unstable	5%
319	Fabry Disease	4.9%
320	Hematoma, Subdural	4.9%
321	Hematoma, Epidural, Cranial	4.9%
322	Hepatolenticular Degeneration	4.8%
323	Brain Injuries, Diffuse	4.8%
324	Traumatic Brain Injury	4.8%
325	Cerebellar Ataxia	4.8%
326	Supratentorial Neoplasms	4.8%
327	Behcet Syndrome	4.8%
328	Waldenstrom Macroglobulinemia	4.7%
329	Multiple Myeloma	4.7%
330	Heart Block	4.7%
331	Tachycardia	4.7%
332	Tachyarrhythmia	4.7%
333	Restless Legs Syndrome	4.7%
334	Aortic coarctation	4.7%
335	Cor Triatriatum	4.7%
336	Coronary Vessel Anomalies	4.7%
337	Patent ductus arteriosus	4.7%
338	Ebstein Anomaly	4.7%
339	Heart Septal Defects	4.7%
340	Tetralogy of Fallot	4.7%
341	Transposition of Great Vessels	4.7%
342	Hypoplastic Left Heart Syndrome	4.7%
343	Sleep Wake Disorders	4.7%
344	Intermittent Claudication	4.6%
345	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	4.6%
346	Paraneoplastic Cerebellar Degeneration	4.6%
347	Spinal Cord Neoplasms	4.6%
348	No-Reflow Phenomenon	4.6%
349	Persistent Vegetative State	4.5%
350	Lemierre Syndrome	4.5%
351	Polyradiculoneuropathy	4.4%
352	Polyradiculoneuritis	4.4%
353	Akathisia, Drug-Induced	4.3%
354	Pseudoxanthoma Elasticum	4.3%
355	Ophthalmoplegic Migraine	4.3%
356	Hepatic Vein Thrombosis	4.3%
357	Budd-Chiari Syndrome	4.3%
358	Reye Syndrome	4.2%
359	Pulmonary Infarction	4.2%
360	Toxoplasmosis, Cerebral	4.2%
361	Hepatic Encephalopathy	4.2%
362	Central Nervous System Fungal Infections	4.2%
363	Conus Medullaris Syndrome	4.2%
364	Autonomic Dysreflexia	4.1%
365	Complex Regional Pain Syndromes	4.1%
366	Dextrocardia	4%
367	Long QT Syndrome	4%
368	Miller Fisher Syndrome	4%
369	MPTP Poisoning	4%
370	Dural Arteriovenous Fistula	4%
371	Encephalomyelitis, Acute Disseminated	4%
372	Leukoencephalitis, Acute Hemorrhagic	3.9%
373	Myelitis, Transverse	3.9%
374	Opsoclonus-Myoclonus Syndrome	3.8%
375	Carcinoid Heart Disease	3.8%
376	Hypertension, Renovascular	3.8%
377	Hereditary Angioedema Type III	3.7%
378	Hereditary Angioedema Types I and II	3.7%
379	Hypertrophic Cardiomyopathy	3.7%
380	Hypertrophic obstructive cardiomyopathy	3.7%
381	Brain Diseases, Metabolic, Inborn	3.6%
382	Mitochondrial Encephalomyopathies	3.6%
383	Friedreich Ataxia	3.5%
384	Dyskinesia, Drug-Induced	3.5%
385	Central Nervous System Bacterial Infections	3.5%
386	Aortic Valve Insufficiency	3.5%
387	Restrictive cardiomyopathy	3.5%
388	Endocardial Fibroelastosis	3.5%
389	Heart Rupture, Post-Infarction	3.5%
390	Mitral Valve Insufficiency	3.5%
391	Mitral Valve Stenosis	3.5%
392	Myocarditis	3.5%
393	Pericarditis, Constrictive	3.5%
394	Pulmonary Valve Insufficiency	3.5%
395	Tricuspid Valve Insufficiency	3.5%
396	Tricuspid Valve Stenosis	3.5%
397	Ventricular Dysfunction, Left	3.5%
398	Right Ventricular Dysfunction	3.5%
399	Endomyocardial Fibrosis	3.5%
400	Carditis	3.5%
401	Heart Failure, Systolic	3.5%
402	Heart Failure, Diastolic	3.5%
403	Coronary Restenosis	3.5%
404	Pituitary Adenoma	3.5%
405	Pituitary Neoplasms	3.5%
406	Post-Traumatic Headache	3.4%
407	Tension Headache	3.4%
408	Epilepsy, Complex Partial	3.4%
409	Migraine Disorders	3.4%
410	Abdominal Migraine	3.4%
411	Status Migrainosus	3.4%
412	Cervicogenic Headache	3.4%
413	Peripheral Nerve Injuries	3.4%
414	Myasthenia Gravis	3.4%
415	Dysautonomia	3.3%
416	Vagus Nerve Disorder	3.3%
417	Glossopharyngeal Neuralgia	3.3%
418	Abducens Nerve Diseases	3.3%
419	Heavy Metal Poisoning, Nervous System	3.3%
420	Neuromuscular Junction Diseases	3.3%
421	Tauopathies	3.3%
422	Trochlear Nerve Diseases	3.3%
423	Peripheral Nervous System Diseases	3.3%
424	Juvenile Myoclonic Epilepsy	3.3%
425	Myoclonic Epilepsies, Progressive	3.3%
426	Canavan Disease	3.3%
427	Alexander Disease	3.3%
428	Auditory Perceptual Disorders	3.2%
429	Noonan Syndrome	3.2%
430	Wernicke Encephalopathy	3.2%
431	AIDS Dementia Complex	3.2%
432	Hematoma, Subdural, Intracranial	3.2%
433	Hematoma, Subdural, Chronic	3.2%
434	Hematoma, Subdural, Acute	3.2%
435	Lambert-Eaton Myasthenic Syndrome	3.1%
436	Supravalvular aortic stenosis	3%
437	Lown-Ganong-Levine Syndrome	3%
438	Sleep Disorders, Circadian Rhythm	3%
439	Scrapie	3%
440	Central Cord Syndrome	3%
441	Cerebral Thrombosis	3%
442	Intracranial Thrombosis	3%
443	Chorea	2.9%
444	Botulism	2.9%
445	Central Nervous System Cysts	2.9%
446	Marfan Syndrome	2.9%
447	Angina Pectoris, Variant	2.9%
448	Kernicterus	2.9%
449	Rheumatoid Vasculitis	2.9%
450	Sick Sinus Syndrome	2.8%
451	Tuberculosis, Meningeal	2.8%
452	Empty Sella Syndrome	2.8%
453	Guillain-Barre Syndrome	2.8%
454	Hyperpituitarism	2.8%
455	Hypopituitarism	2.8%
456	Hypophysitis	2.8%
457	Sinus Arrhythmia	2.8%
458	Atrial Fibrillation	2.8%
459	Atrial Flutter	2.8%
460	Edema, Cardiac	2.8%
461	Ventricular Fibrillation	2.8%
462	Ventricular Flutter	2.8%
463	Parasystole	2.8%
464	Paroxysmal atrial fibrillation	2.8%
465	Bradycardia	2.8%
466	Diabetic Cardiomyopathies	2.8%
467	Myopathy	2.8%
468	Optic Neuropathy	2.8%
469	Cardiomyopathy, Alcoholic	2.8%
470	Ectopia Cordis	2.8%
471	Sudden Cardiac Death	2.8%
472	Left Ventricular Hypertrophy	2.8%
473	Right Ventricular Hypertrophy	2.8%
474	Single umbilical artery	2.8%
475	Chagas Cardiomyopathy	2.8%
476	Progressive bulbar palsy	2.7%
477	Bulbar palsy	2.7%
478	Facial Nerve Diseases	2.7%
479	Craniocerebral Trauma	2.7%
480	Parasomnia	2.7%
481	Dyssomnias	2.7%
482	Subacute Bacterial Endocarditis	2.7%
483	Vestibulocochlear Nerve Diseases	2.7%
484	Decerebrate State	2.7%
485	Hemiparesis	2.7%
486	Hydranencephaly	2.7%
487	Meningism	2.7%
488	Neural Tube Defects	2.7%
489	Paresis	2.7%
490	Seizures	2.7%
491	Sensation Disorders	2.7%
492	Tethered Cord Syndrome	2.7%
493	Central Nervous System Neoplasms	2.7%
494	Complex partial seizures	2.7%
495	Iniencephaly	2.7%
496	Craniorachischisis	2.7%
497	Exencephaly	2.7%
498	Monoparesis	2.7%
499	Septo-Optic Dysplasia	2.7%
500	Cortical Dysplasia	2.7%
501	Neurogenic Inflammation	2.7%
502	Gait Disorders, Neurologic	2.7%
503	Neuromuscular Manifestations	2.7%
504	Malformations of Cortical Development	2.7%
505	Sweating, Gustatory	2.7%
506	Auriculotemporal Syndrome	2.7%
507	Diffuse Axonal Injury	2.6%
508	Brain Stem Neoplasms	2.6%
509	Lafora Disease	2.6%
510	Unverricht-Lundborg Syndrome	2.6%
511	Adams-Stokes Syndrome	2.5%
512	Atrioventricular Block	2.5%
513	Bundle-Branch Block	2.5%
514	Atrial Premature Complexes	2.5%
515	Sinoatrial Block	2.5%
516	Tachycardia, Paroxysmal	2.5%
517	Supraventricular tachycardia	2.5%
518	Tachycardia, Ventricular	2.5%
519	Wolff-Parkinson-White Syndrome	2.5%
520	Tachycardia, Reciprocating	2.5%
521	Aortopulmonary Septal Defect	2.5%
522	Double Outlet Right Ventricle	2.5%
523	Endocardial Cushion Defects	2.5%
524	Myocardial bridging	2.5%
525	Aorticopulmonary Septal Defect	2.5%
526	Frontotemporal dementia	2.5%
527	Olfactory Nerve Injuries	2.5%
528	Horner Syndrome	2.4%
529	Meningitis, Cryptococcal	2.4%
530	Meningitis, Listeria	2.4%
531	Meningitis, Haemophilus	2.4%
532	Meningitis, Pneumococcal	2.4%
533	Torticollis	2.4%
534	Adrenoleukodystrophy	2.4%
535	Dyspnea, Paroxysmal	2.3%
536	Causalgia	2.3%
537	Pupil Disorders	2.3%
538	Neurobehavioral Manifestations	2.3%
539	Multiple Sclerosis	2.3%
540	Brain Contusion	2.3%
541	Paraneoplastic Encephalomyelitis	2.3%
542	Uveomeningoencephalitic Syndrome	2.2%
543	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.2%
544	Neuromyelitis Optica	2.2%
545	Vertigo	2.2%
546	Alcohol-Induced Disorders, Nervous System	2.2%
547	Granulomatosis with polyangiitis	2.2%
548	Brain Concussion	2.2%
549	Facial Nerve Injuries	2.2%
550	Romano-Ward Syndrome	2.2%
551	Jet Lag Syndrome	2.1%
552	Tuberculosis, Central Nervous System	2.1%
553	Reflex Sympathetic Dystrophy	2.1%
554	Nocturnal Myoclonus Syndrome	2.1%
555	Subacute Sclerosing Panencephalitis	2.1%
556	Cluster Headache	2.1%
557	Migraine with Aura	2.1%
558	Familial Hemiplegic Migraine	2.1%
559	Chronic Paroxysmal Hemicrania	2.1%
560	SUNCT Syndrome	2.1%
561	Paroxysmal Hemicrania	2.1%
562	Tuberous Sclerosis	2%
563	Ophthalmoplegia	2%
564	External Ophthalmoplegia	2%
565	Voice Disorders	2%
566	Voice Disturbance	2%
567	Smith-Magenis syndrome	1.9%
568	Myasthenia Gravis, Autoimmune, Experimental	1.9%
569	Refsum Disease	1.9%
570	Aortic Valve Prolapse	1.9%
571	Tricuspid Valve Prolapse	1.9%
572	Takotsubo Cardiomyopathy	1.9%
573	Neuroaspergillosis	1.8%
574	Sinus Thrombosis, Intracranial	1.8%
575	Vocal Cord Paralysis	1.8%
576	Turner Syndrome	1.8%
577	Acrodynia	1.7%
578	Alice in Wonderland Syndrome	1.7%
579	Neuritis	1.7%
580	Polyneuritis	1.7%
581	Radiculitis	1.7%
582	Polyneuropathy	1.7%
583	Mononeuritis	1.7%
584	Mononeuropathies	1.7%
585	Brachial Plexus Neuropathies	1.7%
586	Radiculopathy	1.7%
587	Mononeuropathy Multiplex	1.7%
588	Nerve Root Compression	1.7%
589	Reflex, Abnormal	1.7%
590	Hyporeflexia	1.7%
591	Hyperreflexia	1.7%
592	Hyperprolactinemia	1.7%
593	Pick Disease of the Brain	1.7%
594	Pseudorabies	1.6%
595	Tardive Dyskinesia	1.6%
596	Choroid Plexus Papilloma	1.6%
597	Galactosemias	1.6%
598	Urea Cycle Disorders, Inborn	1.6%
599	Tyrosinemias	1.6%
600	Charcot-Marie-Tooth Disease	1.5%
601	Neurosyphilis	1.5%
602	Kearns-Sayre syndrome	1.5%
603	Alcohol Withdrawal Seizures	1.5%
604	Sinus Arrest, Cardiac	1.5%
605	Myotonia Congenita	1.5%
606	Cerebrospinal Fluid Otorrhea	1.5%
607	Cerebrospinal Fluid Rhinorrhea	1.5%
608	Neuritis, Autoimmune, Experimental	1.5%
609	Gait Ataxia	1.5%
610	Tachycardia, Atrioventricular Nodal Reentry	1.4%
611	Tachycardia, Ectopic Atrial	1.4%
612	Tachycardia, Ectopic Junctional	1.4%
613	Sinus Tachycardia	1.4%
614	Torsades de Pointes	1.4%
615	Accelerated Idioventricular Rhythm	1.4%
616	Truncus Arteriosus, Persistent	1.4%
617	Brachial Plexus Neuritis	1.4%
618	Neuralgic Amyotrophy	1.4%
619	Homocystinuria	1.4%
620	Acromegaly	1.4%
621	Leigh Disease	1.4%
622	Myositis	1.4%
623	Optic Atrophy	1.4%
624	Optic Neuritis	1.4%
625	Papilledema	1.4%
626	Strabismus	1.4%
627	Tolosa-Hunt Syndrome	1.4%
628	Isaacs syndrome	1.4%
629	Arsenic Poisoning	1.4%
630	Myotonic Disorders	1.4%
631	Myasthenic Syndromes, Congenital	1.4%
632	Diabetic Neuropathies	1.4%
633	Facial Injuries	1.4%
634	Facial Neuralgia	1.4%
635	Diabetic Amyotrophy	1.4%
636	Diabetic Autonomic Neuropathy	1.4%
637	Sleep Talking	1.4%
638	Manganese Poisoning	1.4%
639	Sleep Disorders, Intrinsic	1.4%
640	Orthostatic intolerance	1.4%
641	Anosmia	1.4%
642	Ataxia	1.4%
643	Athetosis	1.4%
644	Catalepsy	1.4%
645	Dystonia	1.4%
646	Hemiplegia	1.4%
647	Locked-In Syndrome	1.4%
648	Meningeal Neoplasms	1.4%
649	Meningomyelocele	1.4%
650	Muscle Hypertonia	1.4%
651	Muscle hypotonia	1.4%
652	Myoclonus	1.4%
653	Myotonia	1.4%
654	Neuralgia	1.4%
655	Paraplegia	1.4%
656	Pseudobulbar Palsy	1.4%
657	Quadriplegia	1.4%
658	Spasm	1.4%
659	Spastic Paraplegia	1.4%
660	Status Epilepticus	1.4%
661	Taste Disorders	1.4%
662	Tremor	1.4%
663	Spina Bifida	1.4%
664	Monoplegia	1.4%
665	Hypokinesia	1.4%
666	Paraparesis	1.4%
667	Bradykinesia	1.4%
668	Waxy flexibility	1.4%
669	Action Tremor	1.4%
670	Resting Tremor	1.4%
671	Dysosmia	1.4%
672	Quadriparesis	1.4%
673	Mercury Poisoning, Nervous System	1.4%
674	Olfaction Disorders	1.4%
675	Myokymia	1.4%
676	Lead Poisoning, Nervous System	1.4%
677	Vestibular Neuronitis	1.4%
678	Somatosensory Disorders	1.4%
679	Neuropathic pain	1.4%
680	Hyperkinesia	1.4%
681	Intention tremor	1.4%
682	Lyme Neuroborreliosis	1.3%
683	Coma, Post-Head Injury	1.3%
684	Akathisia	1.3%
685	Restlessness	1.3%
686	Psychomotor Agitation	1.3%
687	Myotonic Dystrophy	1.3%
688	Menkes Kinky Hair Syndrome	1.2%
689	Multiple Sclerosis, Chronic Progressive	1.2%
690	Multiple Sclerosis, Relapsing-Remitting	1.2%
691	Cavernous Sinus Thrombosis	1.2%
692	Vision Disorders	1.2%
693	Metamorphopsia	1.2%
694	Visual Impairment	1.2%
695	Fibromyalgia	1.2%
696	Medial Tibial Stress Syndrome	1.2%
697	West Nile Fever	1.2%
698	Facial Hemiatrophy	1.2%
699	Melkersson-Rosenthal Syndrome	1.2%
700	Mitochondrial Myopathies	1.2%
701	Anisocoria	1.2%
702	Confusion	1.2%
703	Facial paralysis	1.2%
704	Lethargy	1.2%
705	Memory Disorders	1.2%
706	Muscle Cramp	1.2%
707	Perceptual Disorders	1.2%
708	Psychomotor Disorders	1.2%
709	Tonic Pupil	1.2%
710	Eosinophilia-Myalgia Syndrome	1.2%
711	Anhedonia	1.2%
712	Disorientation	1.2%
713	Facial Paresis	1.2%
714	Memory Loss	1.2%
715	Hemisensory Neglect	1.2%
716	Dysacusis	1.2%
717	Williams Syndrome	1.1%
718	Sleep Bruxism	1.1%
719	Acoustic Neuroma	1.1%
720	Anencephaly	1.1%
721	Meningocele	1.1%
722	Muscular Atrophy	1.1%
723	Respiratory Paralysis	1.1%
724	Encephalocele	1.1%
725	Tetany	1.1%
726	Tarsal Tunnel Syndrome	1.1%
727	Cauda Equina Syndrome	1.1%
728	Gait Apraxia	1.1%
729	Zellweger Syndrome	1.1%
730	Prolactinoma	1.1%
731	Growth Hormone-Secreting Pituitary Adenoma	1.1%
732	Kartagener Syndrome	1%
733	Amyloid Neuropathies, Familial	1%
734	Alstrom Syndrome	1%
735	Toxoplasmosis, Congenital	1%
736	Duane Retraction Syndrome	1%
737	Malaria, Cerebral	1%
738	Consciousness Disorders	1%
739	Mental Retardation	1%
740	Muscle Weakness	1%
741	Depressed Level of Consciousness	1%
742	Mental deficiency	1%
743	Intellectual Disability	1%
744	Mobius Syndrome	1%
745	Bell Palsy	1%
746	Neurocysticercosis	1%
747	Catatonia	1%
748	Herpes Zoster Oticus	1%
749	Familial Periodic Paralysis	1%
750	Aphonia	1%
751	Sleep Deprivation	1%
752	Dysphonia	1%
753	Optic Nerve Glioma	1%
754	Carpal Tunnel Syndrome	0.9%
755	neurofibroma	0.9%
756	Sciatica	0.9%
757	Sciatic Neuropathy	0.9%
758	Ulnar Neuropathies	0.9%
759	Lesion of Sciatic Nerve	0.9%
760	Ulnar Neuritis	0.9%
761	Radial nerve compression	0.9%
762	Radial Tunnel Syndrome	0.9%
763	Peroneal Neuropathies	0.9%
764	Radial Neuropathy	0.9%
765	Median Neuropathy	0.9%
766	Sciatic Nerve Palsy	0.9%
767	Femoral Neuropathy	0.9%
768	Tibial Neuropathy	0.9%
769	Ulnar Nerve Palsy	0.9%
770	Postural Orthostatic Tachycardia Syndrome	0.9%
771	Radial nerve palsy	0.9%
772	Myalgia	0.9%
773	Neuronal Ceroid-Lipofuscinoses	0.9%
774	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.8%
775	Waterhouse-Friderichsen Syndrome	0.8%
776	Nelson Syndrome	0.8%
777	Aicardi's syndrome	0.8%
778	Hoarseness	0.8%
779	Cockayne Syndrome	0.8%
780	Alcohol Withdrawal Delirium	0.8%
781	Glycogen storage disease type II	0.8%
782	Esotropia	0.7%
783	Exotropia	0.7%
784	Sleep Apnea Syndromes	0.7%
785	Polymyositis	0.7%
786	Disorders of Excessive Somnolence	0.7%
787	Sleep Initiation and Maintenance Disorders	0.7%
788	Night Terrors	0.7%
789	Somnambulism	0.7%
790	Trigeminal Nerve Disorder	0.7%
791	Transient Insomnia	0.7%
792	Sleep Paralysis	0.7%
793	Chronic Insomnia	0.7%
794	REM Sleep Behavior Disorder	0.7%
795	Hypersomnia	0.7%
796	Dermal Sinus	0.7%
797	Dysgeusia	0.7%
798	Formication	0.7%
799	Hyperalgesia	0.7%
800	Hyperesthesia	0.7%
801	Hypesthesia	0.7%
802	Language Disorders	0.7%
803	Numbness	0.7%
804	Paresthesia	0.7%
805	Paraparesis, Spastic	0.7%
806	Spina Bifida Cystica	0.7%
807	Trismus	0.7%
808	Spina Bifida Occulta	0.7%
809	Epilepsia Partialis Continua	0.7%
810	Hypogeusia	0.7%
811	Meningeal Carcinomatosis	0.7%
812	Brown-Sequard Syndrome	0.7%
813	Lissencephaly	0.7%
814	Polymicrogyria	0.7%
815	Pachygyria	0.7%
816	Schizencephaly	0.7%
817	Lockjaw	0.7%
818	Allodynia	0.7%
819	Lead Poisoning, Nervous System, Childhood	0.7%
820	Lead Poisoning, Nervous System, Adult	0.7%
821	Periventricular Nodular Heterotopia	0.7%
822	Ageusia	0.7%
823	Classical Lissencephalies and Subcortical Band Heterotopias	0.7%
824	Holoprosencephaly	0.7%
825	Cubital Tunnel Syndrome	0.7%
826	Eye Injuries	0.6%
827	Muscular Dystrophy	0.6%
828	Congenital nystagmus	0.6%
829	Orbital Myositis	0.6%
830	Diplopia	0.6%
831	Muscle Rigidity	0.6%
832	Muscle Spasticity	0.6%
833	Scotoma	0.6%
834	Photophobia	0.6%
835	Cogwheel Rigidity	0.6%
836	Hemifacial Spasm	0.6%
837	Amaurosis	0.6%
838	Blindness	0.6%
839	Nuchal Rigidity	0.6%
840	Pyomyositis	0.6%
841	Agnosia	0.6%
842	Apraxias	0.6%
843	Hallucinations	0.6%
844	Hemianopsia	0.6%
845	Hyperacusis	0.6%
846	Tinnitus	0.6%
847	Visual Agnosia	0.6%
848	Anosognosia	0.6%
849	Wernicke-Korsakoff Syndrome	0.6%
850	Phonophobia	0.6%
851	Hearing Loss	0.6%
852	Sarcopenia	0.6%
853	Optic Atrophy, Hereditary, Leber	0.6%
854	Amnesia	0.5%
855	Delirium	0.5%
856	Dissociative Amnesia	0.5%
857	Color blindness	0.5%
858	Global Amnesia	0.5%
859	Cri-du-Chat Syndrome	0.5%
860	Down Syndrome	0.5%
861	Trisomy 21	0.5%
862	POEMS Syndrome	0.5%
863	Meningioma	0.5%
864	Microcephaly	0.5%
865	Macrocephaly	0.5%
866	Hypokalemic periodic paralysis	0.5%
867	Porencephaly	0.5%
868	Alexia	0.5%
869	Dyslexia	0.5%
870	Polyradiculopathy	0.5%
871	Gaucher Disease	0.5%
872	Prader-Willi Syndrome	0.5%
873	Phantom pain	0.4%
874	Phantom Limb Pain	0.4%
875	Sleep Apnea, Obstructive	0.4%
876	Sleep Apnea, Central	0.4%
877	Neurofibrosarcoma	0.4%
878	Narcolepsy	0.4%
879	Trigeminal Neuralgia	0.4%
880	Kleine-Levin Syndrome	0.4%
881	Agraphia	0.4%
882	Anomia	0.4%
883	Cluttering	0.4%
884	Language Development Disorders	0.4%
885	Speech Disorders	0.4%
886	Syncope	0.4%
887	Stupor	0.4%
888	Dysgraphia	0.4%
889	Presyncope	0.4%
890	Dyslalia	0.4%
891	Rubinstein-Taybi Syndrome	0.4%
892	Eye Burns	0.3%
893	Welander Distal Myopathy	0.3%
894	Amaurosis Fugax	0.3%
895	Blindness, Cortical	0.3%
896	Dyscalculia	0.3%
897	Rett Syndrome	0.3%
898	Deafness	0.3%
899	Hearing Loss, Sudden	0.3%
900	Gerstmann Syndrome	0.3%
901	Hearing Loss, Bilateral	0.3%
902	Hearing Loss, High-Frequency	0.3%
903	Hearing Loss, Mixed Conductive-Sensorineural	0.3%
904	Prosopagnosia	0.3%
905	Apraxia, Ideomotor	0.3%
906	Charles Bonnet Syndrome	0.3%
907	Hearing Loss, Unilateral	0.3%
908	Complete Hearing Loss	0.3%
909	Alien Hand Syndrome	0.3%
910	Deaf Mutism	0.3%
911	Niemann-Pick Disease, Type C	0.3%
912	Dermatomyositis	0.3%
913	Corneal Scar	0.3%
914	Muscular Dystrophy, Duchenne	0.3%
915	Tay-Sachs Disease	0.3%
916	Retrograde amnesia	0.3%
917	Amnesia, Anterograde	0.3%
918	Fragile X Syndrome	0.2%
919	Cataplexy	0.2%
920	Aphasia	0.2%
921	Articulation Disorders	0.2%
922	Echolalia	0.2%
923	Stuttering	0.2%
924	Dysphasia	0.2%
925	Mutism	0.2%
926	Selective Mutism	0.2%
927	Mucopolysaccharidosis II	0.2%
928	Corneal Perforation	0.2%
929	Dysarthria	0.2%
930	Alexia, Pure	0.1%

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