MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cor pulmonale

(UMLS:C0034072)

Definition:: Hypertrophy and dilation of the RIGHT VENTRICLE of the heart that is caused by PULMONARY HYPERTENSION. This condition is often associated with pulmonary parenchymal or vascular diseases, such as CHRONIC OBSTRUCTIVE PULMONARY DISEASE and PULMONARY EMBOLISM.
UMLS ID:: C0034072
MeSH ID:: D011660

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.832

Synonym(s)

Cor pulmonale

CARDIOPULMONARY DISEASE

COR PULMONALE

Cardiopulmonary disease or syndrome

Disease;heart;pulmonary

PULMONARY HEART DISEASE

Pulmonary heart disease

Pulmonary heart disease, unspecified

Right heart failure due to disorder of lung

10.

Right heart failure due to pulmonary disease

11.

cardiopulmonary disease

12.

cardiopulmonary diseases

Associated Drug(s)

	Name	Number of Reports	Data Source
1	ambrisentan	FAERS: 53	OFFSIDES US FAERS
2	Rosiglitazone	FAERS: 45	OFFSIDES US FAERS
3	Bosentan	FAERS: 21	US FAERS
4	Alendronate	FAERS: 11	OFFSIDES US FAERS
5	macitentan	FAERS: 8	US FAERS
6	Iloprost	FAERS: 5	OFFSIDES US FAERS
7	rofecoxib	FAERS: 5	US FAERS
8	Tadalafil	FAERS: 4	US FAERS
9	NuvaRing	FAERS: 3	US FAERS
10	Olanzapine	FAERS: 3	US FAERS
11	Sildenafil Citrate	FAERS: 3	OFFSIDES US FAERS
12	indacaterol	FAERS: 3	US FAERS
13	treprostinil	FAERS: 3	US FAERS
14	Epoprostenol	FAERS: 2	US FAERS
15	Fluticasone-Salmeterol Drug Combination	FAERS: 2	US FAERS
16	Lenalidomide	FAERS: 2	US FAERS
17	Megestrol Acetate	FAERS: 2	US FAERS
18	Norgestrel	FAERS: 2	US FAERS
19	Sunitinib	FAERS: 2	US FAERS
20	Zoledronic Acid	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
21	montelukast	FAERS: 2	US FAERS
22	oxybutynin	FAERS: 2	US FAERS
23	riociguat	FAERS: 2	US FAERS
24	Aripiprazole	FAERS: 1	US FAERS
25	Azacitidine	FAERS: 1	US FAERS
26	Bortezomib	FAERS: 1	OFFSIDES US FAERS
27	Capecitabine	FAERS: 1	US FAERS
28	Clozapine	FAERS: 1	US FAERS
29	Dabigatran	FAERS: 1	US FAERS
30	Eplerenone	FAERS: 1	US FAERS
31	Fentanyl	FAERS: 1	US FAERS
32	Fluoxetine	FAERS: 1	US FAERS
33	Ibandronic Acid	FAERS: 1	US FAERS
34	Imatinib Mesylate	FAERS: 1	US FAERS
35	Leuprolide	FAERS: 1	US FAERS
36	Lisinopril	FAERS: 1	US FAERS
37	Morphine	FAERS: 1	US FAERS
38	Moxifloxacin	FAERS: 1	US FAERS
39	Mycophenolic Acid	FAERS: 1	US FAERS
40	Oxycodone	FAERS: 1	US FAERS
41	Pamidronate	FAERS: 1	US FAERS
42	Pioglitazone	FAERS: 1	US FAERS
43	Rivaroxaban	FAERS: 1	US FAERS
44	Rosiglitazone	FAERS: 1	US FAERS
45	Ruxolitinib phosphate	FAERS: 1	US FAERS
46	Sirolimus	FAERS: 1	US FAERS
47	Terazosin	FAERS: 1	US FAERS
48	Teriparatide	FAERS: 1	US FAERS
49	Thalidomide	FAERS: 1	OFFSIDES US FAERS
50	Tiotropium Bromide	FAERS: 1	US FAERS
51	apixaban	FAERS: 1	US FAERS
52	benazepril	FAERS: 1	US FAERS
53	benazepril	FAERS: 1	US FAERS
54	carfilzomib	FAERS: 1	US FAERS
55	nintedanib	FAERS: 1	US FAERS
56	ribociclib	FAERS: 1	US FAERS
57	sibutramine	FAERS: 1	US FAERS
58	Amitriptyline		OFFSIDES
59	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination		OFFSIDES
60	Beclomethasone		OFFSIDES
61	Betaxolol		OFFSIDES
62	Bimatoprost		OFFSIDES
63	Brimonidine Tartrate		OFFSIDES
64	Carbidopa		OFFSIDES
65	Cefadroxil		OFFSIDES
66	Chlorothiazide		OFFSIDES
67	Ciprofloxacin		OFFSIDES
68	Clorazepate Dipotassium		OFFSIDES
69	Clotrimazole		OFFSIDES
70	Cytarabine		OFFSIDES
71	Dasatinib		OFFSIDES SIDER
72	Dermazin		OFFSIDES
73	Dextropropoxyphene		OFFSIDES
74	Doxorubicin		OFFSIDES
75	Doxycycline		OFFSIDES
76	Estramustine		OFFSIDES
77	Etoricoxib		OFFSIDES
78	Flutamide		OFFSIDES
79	Fosinopril		OFFSIDES
80	Glipizide		OFFSIDES
81	Glucovance		OFFSIDES
82	Ibuprofen		OFFSIDES
83	Imipramine		OFFSIDES
84	Ketoconazole		OFFSIDES
85	Lanthanum carbonate hydrate		OFFSIDES
86	Lasofoxifene		SIDER
87	Linezolid		OFFSIDES
88	Metolazone		OFFSIDES
89	Metoprolol		OFFSIDES
90	Milrinone		OFFSIDES
91	Niacin		OFFSIDES
92	Nitroglycerin		OFFSIDES
93	Norethindrone Acetate		OFFSIDES
94	Pamidronate		OFFSIDES
95	Pergolide		OFFSIDES
96	Phenprocoumon		OFFSIDES
97	Pimozide		OFFSIDES
98	Piperacillin, Tazobactam Drug Combination		OFFSIDES
99	Pregabalin		SIDER
100	Primidone		OFFSIDES
101	Rifampin		OFFSIDES
102	Riluzole		OFFSIDES SIDER
103	Salmeterol Xinafoate		OFFSIDES
104	Theophylline		OFFSIDES
105	Tigecycline		OFFSIDES
106	Timolol		OFFSIDES
107	Tobramycin		OFFSIDES
108	Varenicline		SIDER
109	Verapamil		OFFSIDES
110	Vincristine		OFFSIDES
111	Warfarin		OFFSIDES
112	anagrelide		OFFSIDES
113	bismuth subsalicylate		OFFSIDES
114	calcium acetate		OFFSIDES
115	carbidopa, levodopa drug combination		OFFSIDES
116	cefuroxime axetil		OFFSIDES
117	dolasetron		OFFSIDES
118	glimepiride		OFFSIDES
119	pipamperone		OFFSIDES
120	repaglinide		OFFSIDES
121	zafirlukast		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Cardiac Tamponade	42.9%
2	Endocarditis	42.9%
3	Cardiac Arrest	42.9%
4	Heart failure	42.9%
5	Pericardial effusion	42.9%
6	Pericarditis	42.9%
7	Pneumopericardium	42.9%
8	Ventricular Outflow Obstruction	42.9%
9	Ventricular Dysfunction	42.9%
10	Cardiomyopathies	42.9%
11	Pleuropericarditis	42.9%
12	Aortic Valve Stenosis	40.9%
13	Cardiomyopathy, Dilated	40.9%
14	Pulmonary Valve Stenosis	40.9%
15	Myocardial Ischemia	38.1%
16	Hypertrophic Cardiomyopathy	35.2%
17	Hypertrophic obstructive cardiomyopathy	35.2%
18	Supravalvular aortic stenosis	33.3%
19	Lown-Ganong-Levine Syndrome	33.3%
20	Aortic Valve Insufficiency	31%
21	Restrictive cardiomyopathy	31%
22	Endocardial Fibroelastosis	31%
23	Heart Rupture, Post-Infarction	31%
24	Mitral Valve Insufficiency	31%
25	Mitral Valve Stenosis	31%
26	Myocarditis	31%
27	Pericarditis, Constrictive	31%
28	Pulmonary Valve Insufficiency	31%
29	Tricuspid Valve Insufficiency	31%
30	Tricuspid Valve Stenosis	31%
31	Ventricular Dysfunction, Left	31%
32	Right Ventricular Dysfunction	31%
33	Endomyocardial Fibrosis	31%
34	Carditis	31%
35	Heart Failure, Systolic	31%
36	Heart Failure, Diastolic	31%
37	Heart Block	30.5%
38	Tachycardia	30.5%
39	Tachyarrhythmia	30.5%
40	Cardiac Output, High	28.6%
41	Myocardial Stunning	28.6%
42	Low Cardiac Output Syndrome	28.6%
43	Tricuspid Atresia	28.2%
44	Arrhythmogenic Right Ventricular Dysplasia	28.2%
45	Cardiomegaly	27.9%
46	Postpericardiotomy Syndrome	27.9%
47	Cardiac Hypertrophy	27.9%
48	Rheumatic Heart Disease	27.4%
49	Coronary heart disease	27.3%
50	Myocardial Infarction	27.3%
51	Acute Coronary Syndrome	27.3%
52	Myocardial Reperfusion Injury	26.8%
53	Aortic Valve Prolapse	25.4%
54	Tricuspid Valve Prolapse	25.4%
55	Takotsubo Cardiomyopathy	25.4%
56	Adams-Stokes Syndrome	24.8%
57	Atrioventricular Block	24.8%
58	Bundle-Branch Block	24.8%
59	Atrial Premature Complexes	24.8%
60	Sinoatrial Block	24.8%
61	Tachycardia, Paroxysmal	24.8%
62	Supraventricular tachycardia	24.8%
63	Tachycardia, Ventricular	24.8%
64	Wolff-Parkinson-White Syndrome	24.8%
65	Tachycardia, Reciprocating	24.8%
66	Sick Sinus Syndrome	24.6%
67	Long QT Syndrome	24.2%
68	Vascular Diseases	23.1%
69	Coronary Occlusion	22.2%
70	Microvascular Angina	22.2%
71	Coronary Stenosis	22.2%
72	ST segment elevation myocardial infarction	22.2%
73	Tachycardia, Atrioventricular Nodal Reentry	22%
74	Tachycardia, Ectopic Atrial	22%
75	Tachycardia, Ectopic Junctional	22%
76	Sinus Tachycardia	22%
77	Torsades de Pointes	22%
78	Accelerated Idioventricular Rhythm	22%
79	Coronary Aneurysm	21.7%
80	Kounis Syndrome	20.7%
81	Coronary Thrombosis	20.7%
82	Coronary Artery Disease	20.7%
83	Sinus Arrhythmia	20.5%
84	Atrial Fibrillation	20.5%
85	Atrial Flutter	20.5%
86	Edema, Cardiac	20.5%
87	Ventricular Fibrillation	20.5%
88	Ventricular Flutter	20.5%
89	Parasystole	20.5%
90	Paroxysmal atrial fibrillation	20.5%
91	Bradycardia	20.5%
92	Diabetic Cardiomyopathies	20.5%
93	Cardiomyopathy, Alcoholic	20.2%
94	Sudden Cardiac Death	20.2%
95	Left Ventricular Hypertrophy	20.2%
96	Right Ventricular Hypertrophy	20.2%
97	Aortic coarctation	20.2%
98	Cor Triatriatum	20.2%
99	Coronary Vessel Anomalies	20.2%
100	Patent ductus arteriosus	20.2%
101	Ebstein Anomaly	20.2%
102	Heart Septal Defects	20.2%
103	Tetralogy of Fallot	20.2%
104	Transposition of Great Vessels	20.2%
105	Hypoplastic Left Heart Syndrome	20.2%
106	Chagas Cardiomyopathy	20.1%
107	Angina Pectoris	20.1%
108	Coronary Restenosis	19.8%
109	Romano-Ward Syndrome	19.7%
110	Bacterial Endocarditis	18.1%
111	Shock, Cardiogenic	16.7%
112	Sinus Arrest, Cardiac	16.7%
113	Aortopulmonary Septal Defect	16.5%
114	Double Outlet Right Ventricle	16.5%
115	Endocardial Cushion Defects	16.5%
116	Myocardial bridging	16.5%
117	Aorticopulmonary Septal Defect	16.5%
118	Angina, Unstable	16.4%
119	Dextrocardia	16.1%
120	Carcinoid Heart Disease	15.8%
121	Dyspnea, Paroxysmal	15.1%
122	Pregnancy Complications, Cardiovascular	15%
123	Cardiovascular Abnormalities	15%
124	Truncus Arteriosus, Persistent	14.7%
125	Angina Pectoris, Variant	14.6%
126	Aneurysm	14.3%
127	Angiomatosis	14.3%
128	Aortic Diseases	14.3%
129	Arterial Occlusive Diseases	14.3%
130	Hyperemia	14.3%
131	Hypotension	14.3%
132	Superior Vena Cava Syndrome	14.3%
133	Telangiectasis	14.3%
134	Vasculitis	14.3%
135	Venous Insufficiency	14.3%
136	Peripheral Vascular Diseases	14.3%
137	Embolism and Thrombosis	14.3%
138	Angiodysplasia	14.3%
139	Capillary Leak Syndrome	14.3%
140	Prehypertension	14.3%
141	Aortic Aneurysm	13.6%
142	Aortitis	13.6%
143	Leriche Syndrome	13.6%
144	Periphlebitis	13.6%
145	Phlebitis	13.6%
146	Thromboangiitis Obliterans	13.6%
147	Postphlebitic Syndrome	12.4%
148	Thrombophlebitis	11.9%
149	Subacute Bacterial Endocarditis	11.6%
150	Noonan Syndrome	11.5%
151	Blue Toe Syndrome	11.4%
152	Embolism, Amniotic Fluid	11.1%
153	Aortic Aneurysm, Abdominal	11.1%
154	Aortic Aneurysm, Thoracic	11.1%
155	Retinal Vein Occlusion	10.8%
156	Arteriovenous fistula	10.4%
157	Aneurysm, Dissecting	10.3%
158	Arteriosclerosis	10.3%
159	Arteritis	10.3%
160	Embolism	10.3%
161	Erythromelalgia	10.3%
162	Fibromuscular Dysplasia	10.3%
163	Malignant Hypertension	10.3%
164	Raynaud Disease	10.3%
165	Thromboembolism	10.3%
166	Thrombosis	10.3%
167	Essential Hypertension	10.3%
168	Aneurysm, Ruptured	10.3%
169	Iliac Aneurysm	10.3%
170	Pulmonary artery stenosis	10.3%
171	White Coat Hypertension	10.3%
172	Systemic Vasculitis	10.3%
173	Embolus	10.3%
174	Marfan Syndrome	10.2%
175	Malignant Atrophic Papulosis	10.2%
176	Shwartzman Phenomenon	10.1%
177	May-Thurner Syndrome	10.1%
178	Aortic Rupture	10.1%
179	Vascular System Injuries	10%
180	Compartment syndromes	9.5%
181	Hepatic Veno-Occlusive Disease	9.5%
182	Peliosis Hepatis	9.5%
183	Varicocele	9.5%
184	Carotid Artery Thrombosis	9.5%
185	Cerebrovascular Disorders	9.3%
186	Diabetic Angiopathies	9.3%
187	Reperfusion Injury	9.3%
188	Splenic Infarction	9.3%
189	Cerebrovascular Insufficiency	9.3%
190	Vascular Neoplasms	9.3%
191	Spinal Cord Vascular Diseases	9.3%
192	Vasoplegia	9.3%
193	Hemorrhoids	9.2%
194	Thoracic Outlet Syndrome	9.2%
195	Intracranial Embolism and Thrombosis	9.2%
196	Carotid Stenosis	9.1%
197	Intracranial Aneurysm	9.1%
198	Williams Syndrome	9%
199	Arteriosclerosis Obliterans	8.5%
200	Atherosclerosis	8.5%
201	Air Embolism	8.5%
202	Endarteritis	8.5%
203	Venous Thrombosis	8.5%
204	Deep Vein Thrombosis	8.5%
205	Venous Thromboembolism	8.5%
206	Moyamoya Disease	8.4%
207	Polyarteritis Nodosa	8.3%
208	Takayasu Arteritis	8.3%
209	Intracranial Arteriosclerosis	8.2%
210	Cerebral Atherosclerosis	8.2%
211	Cerebral Arteriosclerosis	8.2%
212	Cerebral Thrombosis	7.8%
213	Intracranial Embolism	7.8%
214	Intracranial Thrombosis	7.8%
215	Hand-Arm Vibration Syndrome	7.3%
216	Sinus Thrombosis, Intracranial	7.1%
217	Optic Neuropathy, Ischemic	7%
218	Anterior Ischemic Optic Neuropathy	7%
219	Mesenteric vascular insufficiency	7%
220	Retinal Artery Occlusion	7%
221	Retinal Vasculitis	7%
222	Hypertensive Retinopathy	7%
223	Scimitar Syndrome	6.9%
224	Anterior Compartment Syndrome	6.8%
225	Vasculitis, Leukocytoclastic, Cutaneous	6.8%
226	Gastric Antral Vascular Ectasia	6.8%
227	Abdominal Compartment Syndrome	6.8%
228	Cavernous Sinus Thrombosis	6.8%
229	Sagittal Sinus Thrombosis	6.8%
230	Angioedema	6.8%
231	Vasculitis, Central Nervous System	6.8%
232	Colitis, Ischemic	6.8%
233	Carotid Artery Diseases	6.7%
234	Brain Ischemia	6.7%
235	Ectopia Cordis	6.7%
236	Hypotension, Orthostatic	6.7%
237	Cerebrovascular accident	6.7%
238	Varicose Ulcer	6.7%
239	Vasospasm, Intracranial	6.7%
240	Spinal Cord Ischemia	6.7%
241	Intracranial Arterial Diseases	6.7%
242	Primary Graft Dysfunction	6.7%
243	Single umbilical artery	6.7%
244	Post-Exercise Hypotension	6.7%
245	Brain Infarction	6.5%
246	Lemierre Syndrome	6.3%
247	Giant Cell Arteritis	6.2%
248	Temporal Arteritis	6.2%
249	Infarction, Middle Cerebral Artery	5.9%
250	Infarction, Anterior Cerebral Artery	5.9%
251	Infarction, Posterior Cerebral Artery	5.9%
252	Cerebral Infarction	5.8%
253	Brain Stem Infarctions	5.8%
254	Intermittent Claudication	5.7%
255	Pulmonary Embolism	5.7%
256	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5.7%
257	Subarachnoid Hemorrhage, Traumatic	5.7%
258	Carotid Artery, Internal, Dissection	5.7%
259	No-Reflow Phenomenon	5.6%
260	Turner Syndrome	5.6%
261	Cerebral Arterial Diseases	5.5%
262	Vertebrobasilar Insufficiency	5.5%
263	Anterior Spinal Artery Syndrome	5.5%
264	Basilar Artery Stenosis	5.5%
265	Vertebral Artery Stenosis	5.5%
266	Intracranial Hemorrhage, Hypertensive	5.5%
267	Transient Cerebral Ischemia	5.5%
268	Vertebral Artery Dissection	5.5%
269	Lateral Medullary Syndrome	5.5%
270	Kearns-Sayre syndrome	5.3%
271	Mesenteric Vascular Occlusion	5.2%
272	Mucocutaneous Lymph Node Syndrome	5.2%
273	Kartagener Syndrome	5.2%
274	CREST Syndrome	5.2%
275	Hepatic Vein Thrombosis	5.1%
276	Budd-Chiari Syndrome	5.1%
277	Diabetic Retinopathy	5.1%
278	Sturge-Weber Syndrome	5.1%
279	Livedo Reticularis	5.1%
280	Renal hypertension	5%
281	Renal Artery Obstruction	5%
282	Renal Artery Stenosis	5%
283	Pulmonary Infarction	5%
284	Hemangioma, Cavernous	5%
285	Basal Ganglia Cerebrovascular Disease	5%
286	Vascular Headaches	5%
287	Scurvy	5%
288	Subclavian Steal Syndrome	4.9%
289	Carotid Artery Injuries	4.7%
290	Basal Ganglia Hemorrhage	4.4%
291	Hypertension, Renovascular	4.1%
292	Subarachnoid Hemorrhage	4.1%
293	Hypoxia-Ischemia, Brain	4.1%
294	Cerebral Hemorrhage	4.1%
295	Dural Arteriovenous Fistula	4.1%
296	Hereditary Angioedema Type III	4.1%
297	Hereditary Angioedema Types I and II	4.1%
298	Ischemic contracture	4.1%
299	Angioedemas, Hereditary	4%
300	Putaminal Hemorrhage	4%
301	Cryoglobulinemia	4%
302	Leukomalacia, Periventricular	4%
303	Diabetic Foot	4%
304	Granulomatosis with polyangiitis	3.8%
305	Cerebral Amyloid Angiopathy	3.7%
306	Dementia, Vascular	3.7%
307	Pituitary Apoplexy	3.3%
308	Shy-Drager Syndrome	3.3%
309	Purpura, Hyperglobulinemic	3.3%
310	Behcet Syndrome	2.9%
311	Waldenstrom Macroglobulinemia	2.9%
312	Multiple Myeloma	2.9%
313	Rheumatoid Vasculitis	2.8%
314	Lupus Vasculitis, Central Nervous System	2.7%
315	Ataxia Telangiectasia	2.5%
316	Pseudoxanthoma Elasticum	2.5%
317	Hematoma, Subdural	2.1%
318	Hematoma, Epidural, Cranial	2.1%
319	Hematoma, Subdural, Intracranial	2%
320	Hematoma, Subdural, Chronic	2%
321	Hematoma, Subdural, Acute	2%
322	Brain Hemorrhage, Traumatic	1.8%
323	MELAS Syndrome	1.6%
324	Fabry Disease	1.2%

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