MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Ascorbic Acid Deficiency

(UMLS:C0003969)

Definition:: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
UMLS ID:: C0003969
MeSH ID:: D001206

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.115

Synonym(s)

Ascorbic Acid Deficiency

ASCORBIC ACID DEFICIENCY

Ascorbic acid deficiency

Ascorbic acid deficiency disease

Deficiency of ascorbic acid

Low levels of vitamin C

Vitamin C Deficiency

Vitamin C deficiency

Vitamin C deficiency disease

10.

ascorbic acid deficiency

11.

ascorbic acid; deficiency

12.

deficiency of vitamin c

13.

deficiency; ascorbic acid

14.

deficiency; vitamin, C

15.

of vitamin c deficiency

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ascorbic Acid		19710200	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Vitamin A Deficiency	49.2%
2	Vitamin D Deficiency	49.2%
3	Vitamin E Deficiency	49.2%
4	Folic Acid Deficiency	36.8%
5	Pellagra	36.8%
6	Thiamine Deficiency	36.8%
7	Vitamin B 12 Deficiency	36.8%
8	Vitamin B 6 Deficiency	36.8%
9	Pyridoxine Deficiency	36.8%
10	Magnesium Deficiency	36%
11	Potassium Deficiency	36%
12	Protein Deficiency	36%
13	Beriberi	30.6%
14	Starvation	28.5%
15	Refeeding Syndrome	28.5%
16	Vitamin K Deficiency	25.2%
17	Marasmus	23.8%
18	Child Nutrition Disorders	22.7%
19	Hypervitaminosis A	22.7%
20	Infant Nutrition Disorders	22.7%
21	Wasting Syndrome	20.6%
22	Anemia, Pernicious	20.4%
23	Rickets	18.4%
24	Hyperhomocysteinemia	17.6%
25	Kwashiorkor	16.8%
26	Metabolic Diseases	15.3%
27	Osteomalacia	14.3%
28	Wernicke Encephalopathy	11.9%
29	Subacute Combined Degeneration	10.8%
30	Renal Osteodystrophy	9%
31	Renal rickets	9%
32	Acid-Base Imbalance	7.6%
33	Calcium Metabolism Disorders	7.6%
34	Iron Metabolism Disorders	7.6%
35	Phosphorus Metabolism Disorders	7.6%
36	Water-Electrolyte Imbalance	7.6%
37	Lipid Metabolism Disorders	7.6%
38	Mitochondrial Diseases	7.6%
39	Glucose Metabolism Disorders	7.6%
40	Familial Hypophosphatemic Rickets	5.7%
41	Hypercalcemia	5.5%
42	Hypocalcemia	5.5%
43	Milk-Alkali Syndrome	5.5%
44	HIV Wasting Syndrome	5.4%
45	Osteopenia	5.1%
46	Brain Diseases, Metabolic	5%
47	Obesity	4.8%
48	Lipodystrophy	4.1%
49	Acidosis	4.1%
50	Alkalosis	4.1%
51	Amyloidosis	4.1%
52	Calcinosis	4.1%
53	Hyperglycemia	4.1%
54	Hyperinsulinism	4.1%
55	Hyperkalemia	4.1%
56	Hypernatremia	4.1%
57	Hypoglycemia	4.1%
58	Hypokalemia	4.1%
59	Hyponatremia	4.1%
60	Xanthomatosis	4.1%
61	Hypophosphatemia	4.1%
62	Metabolic acidosis	4.1%
63	Dyslipidemias	4.1%
64	Iron Overload	4.1%
65	Xanthoma	4.1%
66	Obesity, Abdominal	3.6%
67	Pseudohypoparathyroidism	3.5%
68	Brain Diseases, Metabolic, Inborn	3.3%
69	Diabetes Mellitus	2.9%
70	Pediatric Obesity	2.9%
71	Dehydration	2.8%
72	Lipomatosis	2.8%
73	Water Intoxication	2.8%
74	Werner Syndrome	2.8%
75	Achlorhydria	2.7%
76	Amino Acid Metabolism, Inborn Errors	2.7%
77	Bloom Syndrome	2.7%
78	Carbohydrate Metabolism, Inborn Errors	2.7%
79	Metal Metabolism, Inborn Errors	2.7%
80	Osteoporosis	2.7%
81	Progeria	2.7%
82	Lysosomal Storage Diseases	2.7%
83	Bone Demineralization, Pathologic	2.7%
84	Cytochrome-c Oxidase Deficiency	2.7%
85	Peroxisomal Disorders	2.7%
86	Post-Traumatic Osteoporosis	2.7%
87	Celiac Disease	2.7%
88	Sprue, Tropical	2.7%
89	Steatorrhea	2.7%
90	Sprue	2.7%
91	Leigh Disease	2.6%
92	Lactose Intolerance	2.6%
93	Prader-Willi Syndrome	2.5%
94	Hypolipoproteinemias	2.4%
95	Acidosis, Lactic	2.4%
96	Calciphylaxis	2.4%
97	Hemosiderosis	2.4%
98	Ketosis	2.4%
99	Ketonuria	2.4%
100	Ketoacidosis	2.4%
101	Ketonemia	2.4%
102	Vascular calcification	2.4%
103	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.2%
104	Mitochondrial Encephalomyopathies	2.2%
105	Mitochondrial Myopathies	2.1%
106	Smith-Lemli-Opitz Syndrome	2.1%
107	Myelinolysis, Central Pontine	2.1%
108	Galactosemias	2.1%
109	Urea Cycle Disorders, Inborn	2.1%
110	Tyrosinemias	2.1%
111	Glycosuria	2%
112	Reye Syndrome	2%
113	Hepatic Encephalopathy	2%
114	Diabetic Ketoacidosis	2%
115	Congenital Hyperinsulinism	2%
116	Hyperlipidemia, Familial Combined	2%
117	Hyperlipoproteinemia Type IV	1.9%
118	Hyperlipoproteinemia Type V	1.9%
119	Hyperphosphaturia	1.8%
120	Hyperlipoproteinemia Type III	1.8%
121	Porphyrias, Hepatic	1.7%
122	Necrobiosis Lipoidica Diabeticorum	1.6%
123	Acidosis, Respiratory	1.6%
124	Adiposis Dolorosa	1.6%
125	Alkalosis, Respiratory	1.6%
126	Homocystinuria	1.6%
127	Fanconi Anemia	1.6%
128	Renal tubular acidosis	1.6%
129	Alkaptonuria	1.6%
130	Glycogen Storage Disease	1.6%
131	Hypophosphatasia	1.6%
132	Insulin Resistance	1.6%
133	Osteoporosis, Postmenopausal	1.6%
134	Propionic acidemia	1.6%
135	Dihydropyrimidine Dehydrogenase Deficiency	1.6%
136	Cystinosis	1.6%
137	Hypercholesterolemia	1.6%
138	Hyperlipoproteinemias	1.6%
139	Hypertriglyceridemia	1.6%
140	Hypoalphalipoproteinemias	1.6%
141	Amyloid Neuropathies, Familial	1.4%
142	Glycogen storage disease type II	1.4%
143	HIV-Associated Lipodystrophy Syndrome	1.4%
144	Neuronal Ceroid-Lipofuscinoses	1.3%
145	Friedreich Ataxia	1.3%
146	Zellweger Syndrome	1.3%
147	Menkes Kinky Hair Syndrome	1.3%
148	Nesidioblastosis	1.3%
149	MELAS Syndrome	1.3%
150	Gestational Diabetes	1.3%
151	Latent Autoimmune Diabetes in Adults	1.3%
152	Gaucher Disease	1.3%
153	Diabetes Mellitus, Experimental	1.2%
154	Adrenoleukodystrophy	1.2%
155	Hepatolenticular Degeneration	1.2%
156	Nephrocalcinosis	1.2%
157	Tetany	1.2%
158	Refsum Disease	1.2%
159	Glycosuria, Renal	1.2%
160	Cerebral Amyloid Angiopathy	1.2%
161	Kernicterus	1.2%
162	Cockayne Syndrome	1.2%
163	Mucopolysaccharidosis III	1.1%
164	Glycogen Storage Disease Type I	1.1%
165	Glycogen Storage Disease Type V	1.1%
166	Ataxia Telangiectasia	1%
167	Kearns-Sayre syndrome	1%
168	Optic Atrophy, Hereditary, Leber	1%
169	Familial Periodic Paralysis	1%
170	Primary amyloidosis	1%
171	Fabry Disease	1%
172	Variegate Porphyria	1%
173	Acute intermittent porphyria	1%
174	Porphyria Cutanea Tarda	1%
175	Renal Aminoacidurias	1%
176	Fanconi Syndrome	1%
177	Pseudohypoaldosteronism	1%
178	Liddle Syndrome	1%
179	Niemann-Pick Disease, Type C	0.9%
180	Xeroderma Pigmentosum	0.9%
181	Tay-Sachs Disease	0.9%
182	Gout	0.8%
183	Amyotrophic Lateral Sclerosis	0.8%
184	Sjogren-Larsson Syndrome	0.8%
185	Antley-Bixler Syndrome Phenotype	0.8%
186	Canavan Disease	0.7%
187	Alexander Disease	0.7%
188	Mucopolysaccharidosis II	0.7%
189	CREST Syndrome	0.7%
190	Hypokalemic periodic paralysis	0.6%
191	Frontotemporal dementia	0.6%
192	Cystinuria	0.6%
193	Albinism	0.6%
194	Arthritis, Gouty	0.5%
195	Ichthyosis, X-Linked	0.5%

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