MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Shwartzman Phenomenon

(UMLS:C0037018)

Definition:: Hemorrhagic necrosis that was first demonstrated in rabbits with a two-step reaction, an initial local (intradermal) or general (intravenous) injection of a priming endotoxin (ENDOTOXINS) followed by a second intravenous endotoxin injection (provoking agent) 24 h later. The acute inflammation damages the small blood vessels. The following intravascular coagulation leads to capillary and venous THROMBOSIS and NECROSIS. Shwartzman phenomenon can also occur in other species with a single injection of a provoking agent, and during infections or pregnancy. Its susceptibility depends on the status of IMMUNE SYSTEM, coagulation, FIBRINOLYSIS, and blood flow.
UMLS ID:: C0037018
MeSH ID:: D012790

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.454.810|C14.907.940.890

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.463.515.810

Synonym(s)

Shwartzman Phenomenon

SCHWARTZMAN REACTION

Shwartzman phenomenon

Shwartzman reaction

Shwartzman reaction, NOS

Shwartzman reaction, function

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aminocaproic Acid	4562795	CTD
2	Colchicine	4562795	CTD
3	Polyanetholesulfonate	6066602	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Aortitis	42.4%
2	Periphlebitis	42.4%
3	Phlebitis	42.4%
4	Thromboangiitis Obliterans	42.4%
5	Hemangioma, Cavernous	38.3%
6	Scurvy	38.1%
7	Cryoglobulinemia	35.7%
8	Malignant Atrophic Papulosis	35.4%
9	Thrombophlebitis	34.1%
10	Arteritis	33.1%
11	Systemic Vasculitis	33.1%
12	Polyarteritis Nodosa	32.8%
13	Myocardial Ischemia	32.7%
14	Aortic Aneurysm	31.8%
15	Leriche Syndrome	31.8%
16	Purpura, Hyperglobulinemic	31%
17	Aneurysm	30.3%
18	Angiomatosis	30.3%
19	Aortic Diseases	30.3%
20	Arterial Occlusive Diseases	30.3%
21	Hyperemia	30.3%
22	Hypotension	30.3%
23	Superior Vena Cava Syndrome	30.3%
24	Telangiectasis	30.3%
25	Venous Insufficiency	30.3%
26	Peripheral Vascular Diseases	30.3%
27	Embolism and Thrombosis	30.3%
28	Angiodysplasia	30.3%
29	Capillary Leak Syndrome	30.3%
30	Prehypertension	30.3%
31	Waldenstrom Macroglobulinemia	28.9%
32	Retinal Vein Occlusion	28.6%
33	Multiple Myeloma	27.8%
34	Postphlebitic Syndrome	27.6%
35	Retinal Vasculitis	26.8%
36	Vasculitis, Central Nervous System	26.7%
37	Vasculitis, Leukocytoclastic, Cutaneous	26.5%
38	Myocardial Reperfusion Injury	26.4%
39	Coronary Aneurysm	26.2%
40	Takayasu Arteritis	26.2%
41	Splenic Infarction	26.2%
42	Aortic Rupture	25.5%
43	Giant Cell Arteritis	25.4%
44	Temporal Arteritis	25.4%
45	Vascular System Injuries	25.2%
46	Mucocutaneous Lymph Node Syndrome	25.1%
47	Endarteritis	24.6%
48	Blue Toe Syndrome	24.5%
49	Compartment syndromes	24.5%
50	Hepatic Veno-Occlusive Disease	24.5%
51	Peliosis Hepatis	24.5%
52	Varicocele	24.5%
53	Cerebrovascular Disorders	24.2%
54	Diabetic Angiopathies	24.2%
55	Reperfusion Injury	24.2%
56	Cerebrovascular Insufficiency	24.2%
57	Vascular Neoplasms	24.2%
58	Spinal Cord Vascular Diseases	24.2%
59	Vasoplegia	24.2%
60	Hemorrhoids	24%
61	Thoracic Outlet Syndrome	24%
62	Carotid Artery Thrombosis	23.6%
63	Aortic Aneurysm, Abdominal	23.5%
64	Aortic Aneurysm, Thoracic	23.5%
65	Pseudoxanthoma Elasticum	23.3%
66	Moyamoya Disease	23.1%
67	Intracranial Embolism and Thrombosis	23%
68	Carotid Stenosis	22.9%
69	Intracranial Aneurysm	22.9%
70	Coronary Thrombosis	22.8%
71	Coronary Artery Disease	22.8%
72	Arteriovenous fistula	21.8%
73	Disseminated Intravascular Coagulation	21.5%
74	Coronary heart disease	21.2%
75	Myocardial Infarction	21.2%
76	Acute Coronary Syndrome	21.2%
77	Hand-Arm Vibration Syndrome	20.8%
78	Optic Neuropathy, Ischemic	20.3%
79	Anterior Ischemic Optic Neuropathy	20.3%
80	Mesenteric vascular insufficiency	20.3%
81	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	20%
82	Angioedema	19.9%
83	Aneurysm, Dissecting	19.8%
84	Arteriosclerosis	19.8%
85	Embolism	19.8%
86	Erythromelalgia	19.8%
87	Fibromuscular Dysplasia	19.8%
88	Malignant Hypertension	19.8%
89	Raynaud Disease	19.8%
90	Thromboembolism	19.8%
91	Thrombosis	19.8%
92	Essential Hypertension	19.8%
93	Colitis, Ischemic	19.8%
94	Aneurysm, Ruptured	19.8%
95	Iliac Aneurysm	19.8%
96	Pulmonary artery stenosis	19.8%
97	White Coat Hypertension	19.8%
98	Embolus	19.8%
99	Lemierre Syndrome	19.6%
100	Intracranial Arteriosclerosis	19.5%
101	Cerebral Atherosclerosis	19.5%
102	Cerebral Arteriosclerosis	19.5%
103	Thrombocythemia, Essential	19%
104	Kounis Syndrome	17.9%
105	Cerebral Thrombosis	17.8%
106	Intracranial Embolism	17.8%
107	Intracranial Thrombosis	17.8%
108	May-Thurner Syndrome	17.6%
109	Angina Pectoris	17.5%
110	Heart Diseases	17.4%
111	Thrombasthenia	17%
112	Embolism, Amniotic Fluid	16.7%
113	Brain Infarction	16.7%
114	Scimitar Syndrome	16.5%
115	Vitamin K Deficiency	16.4%
116	Retinal Artery Occlusion	16.1%
117	Hypertensive Retinopathy	16.1%
118	Anterior Compartment Syndrome	15.9%
119	Gastric Antral Vascular Ectasia	15.9%
120	Abdominal Compartment Syndrome	15.9%
121	Carotid Artery Diseases	15.8%
122	Brain Ischemia	15.8%
123	Hypotension, Orthostatic	15.8%
124	Cerebrovascular accident	15.8%
125	Varicose Ulcer	15.8%
126	Vasospasm, Intracranial	15.8%
127	Spinal Cord Ischemia	15.8%
128	Intracranial Arterial Diseases	15.8%
129	Primary Graft Dysfunction	15.8%
130	Post-Exercise Hypotension	15.8%
131	Coronary Occlusion	15.7%
132	Microvascular Angina	15.7%
133	Coronary Stenosis	15.7%
134	ST segment elevation myocardial infarction	15.7%
135	Afibrinogenemia	15.5%
136	Factor VII Deficiency	15.5%
137	Factor X Deficiency	15.5%
138	Factor XII Deficiency	15.5%
139	Hemophilia A	15.5%
140	Factor II deficiency	15.5%
141	Factor VIII Deficiency	15.5%
142	Factor V deficiency	15.5%
143	Factor XI Deficiency	15.5%
144	Hypoprothrombinemias	15.5%
145	Subarachnoid Hemorrhage, Traumatic	15.5%
146	Carotid Artery, Internal, Dissection	15.5%
147	Sinus Thrombosis, Intracranial	15.3%
148	CREST Syndrome	15.2%
149	Vasculitis	15.1%
150	Infarction, Middle Cerebral Artery	14.9%
151	Infarction, Anterior Cerebral Artery	14.9%
152	Infarction, Posterior Cerebral Artery	14.9%
153	Protein S Deficiency	14.9%
154	Arteriosclerosis Obliterans	14.8%
155	Atherosclerosis	14.8%
156	Air Embolism	14.8%
157	Venous Thrombosis	14.8%
158	Deep Vein Thrombosis	14.8%
159	Venous Thromboembolism	14.8%
160	Behcet Syndrome	14.7%
161	Vertebral Artery Dissection	14.7%
162	Cavernous Sinus Thrombosis	14.1%
163	Sagittal Sinus Thrombosis	14.1%
164	Pregnancy Complications, Cardiovascular	14%
165	Cardiovascular Abnormalities	14%
166	Cerebral Infarction	13.8%
167	Brain Stem Infarctions	13.8%
168	Granulomatosis with polyangiitis	13.7%
169	Mesenteric Vascular Occlusion	13.4%
170	Diabetic Retinopathy	13.3%
171	Sturge-Weber Syndrome	13.3%
172	Livedo Reticularis	13.3%
173	Renal hypertension	13.2%
174	Renal Artery Obstruction	13.2%
175	Renal Artery Stenosis	13.2%
176	Shwartzman Phenomenon	13.2%
177	Shock, Cardiogenic	13.1%
178	Basal Ganglia Cerebrovascular Disease	13.1%
179	Vascular Headaches	13.1%
180	Carotid Artery Injuries	13%
181	Angina, Unstable	13%
182	Coronary Restenosis	13%
183	Anemia	12.6%
184	Blood Coagulation Disorders	12.6%
185	Blood Platelet Disorders	12.6%
186	Bone Marrow Diseases	12.6%
187	Leukocyte Disorders	12.6%
188	Methemoglobinemia	12.6%
189	Pancytopenia	12.6%
190	Polycythemia	12.6%
191	Sulfhemoglobinemia	12.6%
192	Thrombophilia	12.6%
193	Erythrocytosis	12.6%
194	Lateral Medullary Syndrome	12.4%
195	Rheumatoid Vasculitis	12.3%
196	Intermittent Claudication	12%
197	Pulmonary Embolism	12%
198	No-Reflow Phenomenon	11.8%
199	Basal Ganglia Hemorrhage	11.8%
200	Cerebral Arterial Diseases	11.7%
201	Vertebrobasilar Insufficiency	11.7%
202	Anterior Spinal Artery Syndrome	11.7%
203	Basilar Artery Stenosis	11.7%
204	Vertebral Artery Stenosis	11.7%
205	Intracranial Hemorrhage, Hypertensive	11.7%
206	Transient Cerebral Ischemia	11.7%
207	Wiskott-Aldrich Syndrome	11.5%
208	Ischemic contracture	11.4%
209	Angioedemas, Hereditary	11.3%
210	Tricuspid Atresia	11.3%
211	Antithrombin III Deficiency	11.3%
212	Arrhythmogenic Right Ventricular Dysplasia	11.3%
213	Protein C Deficiency	11.3%
214	Leukomalacia, Periventricular	11.3%
215	Diabetic Foot	11.2%
216	Lupus Vasculitis, Central Nervous System	11.1%
217	Angina Pectoris, Variant	10.8%
218	Aortic Valve Stenosis	10.6%
219	Cardiomyopathy, Dilated	10.6%
220	Pulmonary Valve Stenosis	10.6%
221	Transfusion Reaction	10.5%
222	Hypotensive Transfusion Reaction	10.5%
223	Pregnancy Complications, Hematologic	10.2%
224	Hematologic Neoplasms	10.2%
225	Putaminal Hemorrhage	10.1%
226	Cardiac Tamponade	10.1%
227	Endocarditis	10.1%
228	Cardiac Arrest	10.1%
229	Heart failure	10.1%
230	Pericardial effusion	10.1%
231	Pericarditis	10.1%
232	Pneumopericardium	10.1%
233	Cor pulmonale	10.1%
234	Ventricular Outflow Obstruction	10.1%
235	Ventricular Dysfunction	10.1%
236	Cardiomyopathies	10.1%
237	Pleuropericarditis	10.1%
238	Hepatic Vein Thrombosis	10%
239	Budd-Chiari Syndrome	10%
240	Bone Marrow Neoplasms	9.9%
241	Thrombocytosis	9.9%
242	Activated Protein C Resistance	9.9%
243	Pulmonary Infarction	9.8%
244	Shy-Drager Syndrome	9.8%
245	Hypertension, Renovascular	9.8%
246	Subarachnoid Hemorrhage	9.8%
247	Hypoxia-Ischemia, Brain	9.8%
248	Cerebral Hemorrhage	9.8%
249	Subclavian Steal Syndrome	9.7%
250	Dementia, Vascular	9.7%
251	Hereditary Angioedema Type III	9.7%
252	Hereditary Angioedema Types I and II	9.7%
253	Bacterial Endocarditis	9.7%
254	Autoimmune thrombocytopenia	9.6%
255	Immune thrombocytopenic purpura	9.6%
256	Heart Block	8.8%
257	Tachycardia	8.8%
258	Tachyarrhythmia	8.8%
259	Aortic coarctation	8.8%
260	Cor Triatriatum	8.8%
261	Coronary Vessel Anomalies	8.8%
262	Patent ductus arteriosus	8.8%
263	Ebstein Anomaly	8.8%
264	Heart Septal Defects	8.8%
265	Tetralogy of Fallot	8.8%
266	Transposition of Great Vessels	8.8%
267	Hypoplastic Left Heart Syndrome	8.8%
268	Hypertrophic Cardiomyopathy	8.5%
269	Hypertrophic obstructive cardiomyopathy	8.5%
270	Pituitary Apoplexy	8.5%
271	Polycythemia Vera	8.4%
272	Cardiac Output, High	8.2%
273	Myocardial Stunning	8.2%
274	Low Cardiac Output Syndrome	8.2%
275	Cerebral Amyloid Angiopathy	8.1%
276	Cardiomegaly	8.1%
277	Postpericardiotomy Syndrome	8.1%
278	Cardiac Hypertrophy	8.1%
279	Ataxia Telangiectasia	8%
280	Rheumatic Heart Disease	8%
281	Supravalvular aortic stenosis	7.8%
282	Hemoglobinuria, Paroxysmal	7.8%
283	Leukemoid Reaction	7.8%
284	Lown-Ganong-Levine Syndrome	7.8%
285	Lymphatic Diseases	7.8%
286	Dextrocardia	7.5%
287	Long QT Syndrome	7.5%
288	Anemia, Hemolytic	7.4%
289	Anemia, Macrocytic	7.4%
290	Eosinophilia	7.4%
291	Hypoproteinemia	7.4%
292	Leukopenia	7.4%
293	Thrombocytopenia	7.4%
294	Leukostasis	7.4%
295	MYELODYSPLASTIC SYNDROME	7.4%
296	Sick Sinus Syndrome	7.3%
297	Waterhouse-Friderichsen Syndrome	7.3%
298	Purpura, Thrombotic Thrombocytopenic	7%
299	Anemia, Diamond-Blackfan	7%
300	Agammaglobulinemia	6.7%
301	Aortic Valve Insufficiency	6.6%
302	Restrictive cardiomyopathy	6.6%
303	Endocardial Fibroelastosis	6.6%
304	Heart Rupture, Post-Infarction	6.6%
305	Mitral Valve Insufficiency	6.6%
306	Mitral Valve Stenosis	6.6%
307	Myocarditis	6.6%
308	Pericarditis, Constrictive	6.6%
309	Pulmonary Valve Insufficiency	6.6%
310	Tricuspid Valve Insufficiency	6.6%
311	Tricuspid Valve Stenosis	6.6%
312	Ventricular Dysfunction, Left	6.6%
313	Right Ventricular Dysfunction	6.6%
314	Endomyocardial Fibrosis	6.6%
315	Carditis	6.6%
316	Heart Failure, Systolic	6.6%
317	Heart Failure, Diastolic	6.6%
318	Adams-Stokes Syndrome	6.5%
319	Atrioventricular Block	6.5%
320	Bundle-Branch Block	6.5%
321	Atrial Premature Complexes	6.5%
322	Sinoatrial Block	6.5%
323	Tachycardia, Paroxysmal	6.5%
324	Supraventricular tachycardia	6.5%
325	Tachycardia, Ventricular	6.5%
326	Wolff-Parkinson-White Syndrome	6.5%
327	Tachycardia, Reciprocating	6.5%
328	Aortopulmonary Septal Defect	6.5%
329	Double Outlet Right Ventricle	6.5%
330	Endocardial Cushion Defects	6.5%
331	Myocardial bridging	6.5%
332	Aorticopulmonary Septal Defect	6.5%
333	Anemia, Sickle Cell	6.4%
334	Thalassemia	6.4%
335	Anemia, Neonatal	6%
336	Leukocytosis	6%
337	Paraproteinemias	6%
338	Pelger-Huet Anomaly	6%
339	Pleocytosis	6%
340	Noonan Syndrome	5.9%
341	Subacute Bacterial Endocarditis	5.7%
342	Infectious Mononucleosis	5.7%
343	Monoclonal Gammopathy of Undetermined Significance	5.6%
344	Carcinoid Heart Disease	5.6%
345	Romano-Ward Syndrome	5.6%
346	Hematoma, Subdural	5.4%
347	Tachycardia, Atrioventricular Nodal Reentry	5.4%
348	Tachycardia, Ectopic Atrial	5.4%
349	Tachycardia, Ectopic Junctional	5.4%
350	Sinus Tachycardia	5.4%
351	Torsades de Pointes	5.4%
352	Accelerated Idioventricular Rhythm	5.4%
353	Hematoma, Epidural, Cranial	5.4%
354	Truncus Arteriosus, Persistent	5.4%
355	Marfan Syndrome	5.4%
356	Sinus Arrhythmia	5.3%
357	Atrial Fibrillation	5.3%
358	Atrial Flutter	5.3%
359	Edema, Cardiac	5.3%
360	Ventricular Fibrillation	5.3%
361	Ventricular Flutter	5.3%
362	Parasystole	5.3%
363	Paroxysmal atrial fibrillation	5.3%
364	Bradycardia	5.3%
365	Diabetic Cardiomyopathies	5.3%
366	Cardiomyopathy, Alcoholic	5.3%
367	Ectopia Cordis	5.3%
368	Sudden Cardiac Death	5.3%
369	Left Ventricular Hypertrophy	5.3%
370	Right Ventricular Hypertrophy	5.3%
371	Single umbilical artery	5.3%
372	Chagas Cardiomyopathy	5.2%
373	Hypergammaglobulinemia	5.1%
374	Transfusion-Related Acute Lung Injury	5%
375	Ecchymosis	5%
376	Petechiae	5%
377	Purpura	5%
378	Heavy Chain Disease	4.9%
379	Primary Myelofibrosis	4.9%
380	Agranulocytosis	4.9%
381	Anemia, Megaloblastic	4.9%
382	Aortic Valve Prolapse	4.9%
383	Lymphocytosis	4.9%
384	Myelofibrosis	4.9%
385	Myeloid Metaplasia	4.9%
386	Tricuspid Valve Prolapse	4.9%
387	Hypoalbuminemia	4.9%
388	Hypereosinophilic syndrome	4.9%
389	Takotsubo Cardiomyopathy	4.9%
390	bone marrow fibrosis	4.9%
391	Thrombotic Microangiopathies	4.9%
392	Hemolytic-Uremic Syndrome	4.9%
393	Brain Hemorrhage, Traumatic	4.9%
394	MELAS Syndrome	4.8%
395	Hematoma, Subdural, Intracranial	4.8%
396	Hematoma, Subdural, Chronic	4.8%
397	Hematoma, Subdural, Acute	4.8%
398	Sickle Cell Trait	4.5%
399	Hydrops Fetalis	4.5%
400	Dyspnea, Paroxysmal	4.4%
401	Thrombocytopenic purpura	4.4%
402	Fanconi Anemia	4.2%
403	Adenitis	4.2%
404	Histiocytosis	4.2%
405	Lymphadenitis	4.2%
406	Lymphangitis	4.2%
407	Lymphedema	4.2%
408	Splenic Diseases	4.2%
409	Thymus Hyperplasia	4.2%
410	Pseudolymphoma	4.2%
411	Lymphadenopathy	4.2%
412	Lymphopenia	4%
413	Job Syndrome	3.9%
414	Leukemia, Myelomonocytic, Chronic	3.9%
415	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.9%
416	Sinus Arrest, Cardiac	3.9%
417	Fabry Disease	3.8%
418	Dural Arteriovenous Fistula	3.8%
419	Atypical Hemolytic Uremic Syndrome	3.8%
420	Neutropenia	3.7%
421	Acute Chest Syndrome	3.6%
422	Lymphocele	3.4%
423	Lymphoproliferative Disorders	3.4%
424	Lymphatic Abnormalities	3.4%
425	Thymus Neoplasms	3.4%
426	Kernicterus	3.3%
427	Eosinophilia-Myalgia Syndrome	3.3%
428	Lymphangiectasis, Intestinal	3.3%
429	Eosinophilic Granuloma	3.3%
430	Chronic granulomatous disease	3.3%
431	Purpura Fulminans	3.3%
432	Turner Syndrome	3.2%
433	Febrile Neutropenia	3.1%
434	Pulmonary Eosinophilia	3%
435	Eosinophilic Pneumonia	3%
436	Leukemia, Myeloid, Chronic-Phase	2.9%
437	Anemia, Pernicious	2.9%
438	POEMS Syndrome	2.8%
439	Kartagener Syndrome	2.7%
440	Elephantiasis	2.5%
441	Hypersplenism	2.5%
442	Sarcoidosis	2.5%
443	Elephantiasis Nostras Verrucosa	2.5%
444	Williams Syndrome	2.3%
445	Granuloma	2%
446	Histiocytic Disorders, Malignant	2%
447	Splenic Neoplasms	2%
448	Kearns-Sayre syndrome	2%
449	Histiocytosis, Langerhans-Cell	2%
450	Tumor Lysis Syndrome	2%
451	Splenic Rupture	1.7%
452	Lymphoma	1.7%
453	Sezary Syndrome	1.7%
454	Thymoma	1.6%
455	Lymphohistiocytosis, Hemophagocytic	1.6%
456	Erdheim-Chester Disease	1.6%
457	Autoimmune Lymphoproliferative Syndrome	1.4%
458	Malignant histiocytosis	1.3%
459	Sarcoidosis, Pulmonary	1.3%
460	Histiocytic sarcoma	1.3%
461	Splenosis	1.1%
462	Hodgkin Disease	1.1%
463	Lymphoma, Non-Hodgkin	1.1%
464	Leukemia, T-Cell	1.1%
465	Leukemia, B-Cell	1.1%
466	Composite Lymphoma	0.9%
467	Lymphangioleiomyomatosis	0.9%
468	Lymphoma, Follicular	0.8%
469	T-Cell Lymphoma	0.8%
470	Mantle cell lymphoma	0.8%
471	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
472	Leukemia, Large Granular Lymphocytic	0.8%
473	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.8%
474	Lymphoma, T-Cell, Cutaneous	0.7%
475	Lymphoma, AIDS-Related	0.7%
476	Enteropathy-Associated T-Cell Lymphoma	0.7%
477	Primary Effusion Lymphoma	0.7%
478	Mycosis Fungoides	0.6%
479	Lymphomatoid Papulosis	0.6%
480	Plasmablastic lymphoma	0.6%
481	Lymphomatoid Granulomatosis	0.6%
482	Burkitt Lymphoma	0.5%
483	Niemann-Pick Disease, Type C	0.4%

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