MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypokalemia

(UMLS:C0020621)

Definition:: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
UMLS ID:: C0020621
MeSH ID:: D007008

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.950.565

Synonym(s)

Hypokalemia

HYPOKALAEMIA

HYPOKALEMIA

HYPOPOTASSEMIA

HYPOPOTASSEMIA SYNDROME

Hypokalaemia

Hypokalaemic syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	18-hydroxydeoxycorticosterone	11993792	CTD
2	9-fluoroprednisolone	87768	CTD
3	Acetaminophen	View details 12088358 17594792 18047475 18275687	CTD
4	Acetazolamide	7031501	CTD
5	Albuterol	View details 92737 719960 2209135 2567672 2575521 2712984 2729315 2762609 2829953 2876313 3320735 3330186 3408637 3545273 3956296 7867231 7893301 8098220 8285977 8681661 9311181 9583400 9616533 10023788 11729705 12972899 15232249 18412527	CTD
6	Aldosterone	7285864	CTD
7	Amikacin	856439 8950843 19884751	CTD
8	Amiloride	View details 3045028 3290263 3296979 6478730 7018361 7334141 7357812 10669191 11418519	CTD
9	Ampicillin	326044	CTD
10	Aspirin	17303035	CTD
11	Atenolol	View details 2575521 2885202 3010693 11332259 12795776	CTD
12	Atropine	3168573	CTD
13	Azlocillin	4074446	CTD
14	Bendroflumethiazide	View details 326460 417199 594295 2209135 2570476 2729315 6134137 6487484 17452686	CTD
15	Betamethasone	19249894 21252779	CTD
16	Bisacodyl	7828395	CTD
17	Bisoprolol	8098220 12795776	CTD
18	Bromazepam	17092685	CTD
19	Budesonide	9138184	CTD
20	Bumetanide	9824779	CTD
21	Caffeine	View details 3740695 7909771 10337936 11336759 11512607 20513219	CTD
22	Capecitabine	18360625 19584382	CTD
23	Carbenicillin	View details 7687 983629 1067752 4110324 4711781 7368345	CTD
24	Carbenoxolone	234288	CTD
25	Carboplatin	11219485	CTD
26	Cephalothin	4110324	CTD
27	Chloroquine	7564673 16142151	CTD
28	Chlorothiazide	5668173	CTD
29	Chlorthalidone	View details 28952 29653 361988 697472 796642 883995 1686258 3546168 3704734 3894256 4041299 5108572 6366805 7158222 7332917 10818057 18981326	CTD
30	Clindamycin	4110324	CTD
31	Clofazimine	16295502	CTD
32	Cloxacillin	9547205	CTD
33	Cocaine	12082066	CTD
34	Codeine	15605674	CTD
35	Colistin	646445	CTD
36	Corticosterone	9881897 11993792	CTD
37	Cyclopenthiazide	62899 4041299	CTD
38	Cyclophosphamide	582354 10637075	CTD
39	Desoxycorticosterone	9881897	CTD
40	Dexamethasone	174842 11085685	CTD
41	Diazepam	7497894	CTD
42	Dicloxacillin	12088358	CTD
43	Didanosine	1670826	CTD
44	Digoxin	1259829 2311237 6603084	CTD
45	Diphenhydramine	7497894	CTD
46	Dobutamine	2471006	CTD
47	Doxorubicin	1617512	CTD
48	Enalapril	1623802 6100872	CTD
49	Epinephrine	View details 1032269 2468922 2600984 2863970 2885202 2893535 2905711 3010693 3320735 3402518 3545273 3632961 5013151 6134137 6143631 6314140 6861446 16164400	CTD
50	Erythromycin	9733356	CTD
51	Ethacrynic Acid	5090186	CTD
52	Etoposide	1339077	CTD
53	Fenoterol	2567672 2627224 2829953	CTD
54	Flecainide	17452686	CTD
55	Flucytosine	18359968	CTD
56	Fludrocortisone	View details 496411 668870 4740571 9014799	CTD
57	Fluprednisolone	4017458	CTD
58	Foscarnet	1335467 8384030	CTD
59	Furosemide	View details 62899 657047 759067 2264472 3572225 3885386 6708393 6883959 7182184 8595691 8996656 9284855 9533377 10437370 11749789 16404129 17879355 18259658	CTD
60	Gentamicins	View details 727798 856439 1067752 2331318 4110324 7354245 12571406	CTD
61	Haloperidol	2735214	CTD
62	Hydrochlorothiazide	View details 238860 869273 1179459 2596940 2642658 2669155 2987608 3045028 3296979 3524185 3538913 3548301 6100872 6373442 6478730 6482509 6496322 6497518 6848810 6942642 7018361 7021608 7211912 7325135 7334141 7370875 7619654 7636894 7662229 8006914 9883710 10401023 10652038 11332259 11865109 14561806 17379047 17928827 19043288 19637407 19792989 23707192	CTD
63	Hydrocortisone	View details 7703757 15090754 17278127 17879355	CTD
64	Hydroxychloroquine	15582773 16142151	CTD
65	ICI 118551	6143631 6314140	CTD
66	Ibuprofen	View details 10341751 15605674 15632232 20513219	CTD
67	Ifosfamide	View details 2567921 2806353 2896952 16174228	CTD
68	Indapamide	View details 673684 693289 724465 1705875 1853463 1998577 2216949 2711019 3047887 4017458 4053543 6237845 6346846 6802373 6869205 8573958 9867313 11999238 12088485 12380780 18386633 18507554	CTD
69	Indomethacin	3727353	CTD
70	Irinotecan	19584382	CTD
71	Isoproterenol	View details 228309 2468922 6621246 7685286	CTD
72	Itraconazole	View details 7817346 8389392 8586896 10087874 14628780 16722159	CTD
73	Ketamine	442425	CTD
74	Levodopa	851038	CTD
75	Lidoderm	8669646	CTD
76	Lithium Carbonate	870987 5071967 11180215	CTD
77	Magnesium Sulfate	7828395	CTD
78	Mannitol	20804114	CTD
79	Meperidine	12088358	CTD
80	Metaproterenol	3168573	CTD
81	Methicillin	1067752 4110324	CTD
82	Methotrexate	12721279	CTD
83	Methylprednisolone	2721092 16467598 17827844	CTD
84	Metipranolol	29653	CTD
85	Metolazone	6860532 6883959	CTD
86	Mifepristone	19289534	CTD
87	Mitomycin	1339077	CTD
88	Morphine	17303035	CTD
89	Nafcillin	448989 1067752 7431181	CTD
90	Nandrolone Decanoate	15849280	CTD
91	Neomycin	646445	CTD
92	Nifedipine	2284794 3709348	CTD
93	Norepinephrine	8734244	CTD
94	Ondansetron	18176182	CTD
95	Oxacillin	3215112	CTD
96	Oxprenolol	2565392 2826064 2885202	CTD
97	Oxymetholone	15849280	CTD
98	Paroxetine	16958954 17092685	CTD
99	Penicillin G	5722316	CTD
100	Physostigmine	7497894	CTD
101	Piperacillin, Tazobactam Drug Combination	20642978	CTD
102	Polymyxin B	646445	CTD
103	Polythiazide	361988	CTD
104	Potassium	View details 2596940 3524185 7021608 7893301 19637407	CTD
105	Potassium Chloride	View details 3045028 3662713 4606449 6195908 6731517 7357812 7828395 10652038 16164400 18412527	CTD
106	Prednisolone	1497563	CTD
107	Propranolol	2600984 2885202	CTD
108	Pyrazinamide	4340029	CTD
109	Quetiapine Fumarate	15754671	CTD
110	Quinapril	8006914	CTD
111	Quinidine	3571742	CTD
112	Quinine	9517707	CTD
113	Risperidone	15754671	CTD
114	Ritodrine	View details 3883263 3963085 6638123 6731517 6862070 7148909 9186877	CTD
115	Rosiglitazone	19656910	CTD
116	Sirolimus	View details 10221490 12742468 12742489 17347279 19656910	CTD
117	Sisomicin	856439	CTD
118	Sotalol	1032269 9733356	CTD
119	Spironolactone	View details 323586 1623802 2209135 2264472 6860532 7357812 10100081 11868798 15811903 15949161	CTD
120	Stanozolol	15849280	CTD
121	Streptomycin	8086909	CTD
122	Streptozocin	11219485	CTD
123	Tenofovir	16868451	CTD
124	Terbutaline	View details 1623802 1848636 2563217 2565392 2567672 2826064 3707814 4052188 6108735 7197475 9186877 11729705 12795776 15654267 17292646	CTD
125	Terfenadine	16722159	CTD
126	Tetracaine	900457	CTD
127	Theophylline	View details 2596942 2973024 3330186 3408637 3662713 3707814 3940495 6506685 8177851 18724532	CTD
128	Thiopental	12209290	CTD
129	Ticarcillin	983629 7094288 7448842	CTD
130	Timolol	238860 326460	CTD
131	Tobramycin	856439 7095860 12571406	CTD
132	Triamterene	View details 2209135 2596940 3045028 3727353 6195908	CTD
133	Trimethoprim, Sulfamethoxazole Drug Combination	9238447	CTD
134	Valproic Acid	11891102	CTD
135	Vancomycin	17344665 21148517	CTD
136	Vinblastine	3686684	CTD
137	Vincristine	582354	CTD
138	Viomycin	4340029	CTD
139	Xipamide	6802373 6804002 12528327	CTD
140	Zolpidem	17092685	CTD
141	amiloride, hydrochlorothiazide drug combination	7393077 14645639	CTD
142	amphotericin B, deoxycholate drug combination	View details 9272385 17597057 19935267 20140311	CTD
143	boldenone	15849280	CTD
144	candesartan	11332259	CTD
145	carbidopa, levodopa drug combination	2471006	CTD
146	cetamolol	2468922 2905711	CTD
147	cyclothiazide	7128662	CTD
148	liposomal amphotericin B	View details 463822 1497007 2368770 3290263 5171904 5361408 5536569 5634966 7317148 8589134 8589135 9208117 9578177 10669191 10959350 11418519 11868798 12562731 15942094 16906399 17879355 18039077 18359968 19282576	CTD
149	polystyrene sulfonic acid	3197055 3782641	CTD
150	potassium-magnesium citrate	10401023	CTD
151	pyrogastrone	3572225	CTD
152	telavancin	21148517	CTD
153	testosterone 17-phenylpropionate	15849280	CTD
154	ticarcillin-clavulanic acid	8259044	CTD
155	trimethyltin chloride	20211677	CTD
156	triuret	20371222	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperkalemia	46.7%
2	Hypernatremia	46.7%
3	Hyponatremia	46.7%
4	Hypercalcemia	44.4%
5	Hypocalcemia	44.4%
6	Milk-Alkali Syndrome	44.4%
7	Dehydration	31.8%
8	Water Intoxication	31.8%
9	Acid-Base Imbalance	31%
10	Calcium Metabolism Disorders	31%
11	Iron Metabolism Disorders	31%
12	Phosphorus Metabolism Disorders	31%
13	Lipid Metabolism Disorders	31%
14	Mitochondrial Diseases	31%
15	Glucose Metabolism Disorders	31%
16	Wasting Syndrome	27.9%
17	Osteopenia	20.9%
18	Brain Diseases, Metabolic	20.5%
19	Acidosis	20%
20	Alkalosis	20%
21	Amyloidosis	20%
22	Calcinosis	20%
23	Hyperglycemia	20%
24	Hyperinsulinism	20%
25	Hypoglycemia	20%
26	Lipodystrophy	20%
27	Xanthomatosis	20%
28	Hypophosphatemia	20%
29	Metabolic acidosis	20%
30	Dyslipidemias	20%
31	Iron Overload	20%
32	Xanthoma	20%
33	Nutrition Disorders	18.5%
34	Pseudohypoparathyroidism	18.1%
35	Rickets	17.3%
36	Brain Diseases, Metabolic, Inborn	15.9%
37	Leigh Disease	15.2%
38	Hyperhomocysteinemia	15.1%
39	Acidosis, Lactic	14.8%
40	Calciphylaxis	14.8%
41	Hemosiderosis	14.8%
42	Ketosis	14.8%
43	Ketonuria	14.8%
44	Ketoacidosis	14.8%
45	Ketonemia	14.8%
46	Vascular calcification	14.8%
47	Hypolipoproteinemias	14.6%
48	Hyperlipoproteinemia Type IV	14.5%
49	Hyperlipoproteinemia Type V	14.5%
50	Diabetes Mellitus	14.3%
51	Carbamoyl-Phosphate Synthase I Deficiency Disease	13.8%
52	Lactose Intolerance	13.7%
53	Lipomatosis	13.6%
54	Werner Syndrome	13.6%
55	Diabetic Ketoacidosis	13.5%
56	Hyperlipidemia, Familial Combined	13.4%
57	Achlorhydria	13.3%
58	Amino Acid Metabolism, Inborn Errors	13.3%
59	Bloom Syndrome	13.3%
60	Carbohydrate Metabolism, Inborn Errors	13.3%
61	Metal Metabolism, Inborn Errors	13.3%
62	Osteoporosis	13.3%
63	Progeria	13.3%
64	Lysosomal Storage Diseases	13.3%
65	Bone Demineralization, Pathologic	13.3%
66	Cytochrome-c Oxidase Deficiency	13.3%
67	Peroxisomal Disorders	13.3%
68	Post-Traumatic Osteoporosis	13.3%
69	Celiac Disease	13.2%
70	Sprue, Tropical	13.2%
71	Steatorrhea	13.2%
72	Sprue	13.2%
73	Osteomalacia	13%
74	Hyperlipoproteinemia Type III	12.7%
75	Smith-Lemli-Opitz Syndrome	12.6%
76	Galactosemias	12.5%
77	Urea Cycle Disorders, Inborn	12.5%
78	Tyrosinemias	12.5%
79	Hypercholesterolemia	12.2%
80	Hyperlipoproteinemias	12.2%
81	Hypertriglyceridemia	12.2%
82	Congenital Hyperinsulinism	12.2%
83	Hypoalphalipoproteinemias	12%
84	Familial Hypophosphatemic Rickets	11.5%
85	Mitochondrial Encephalomyopathies	11.5%
86	Gaucher Disease	10.9%
87	Hyperphosphaturia	10.9%
88	Glycogen storage disease type II	10.6%
89	Homocystinuria	10.4%
90	Child Nutrition Disorders	10.3%
91	Hypervitaminosis A	10.3%
92	Infant Nutrition Disorders	10.3%
93	Malnutrition	10.3%
94	Mitochondrial Myopathies	10.2%
95	Myelinolysis, Central Pontine	10.1%
96	Glycosuria	9.9%
97	Reye Syndrome	9.9%
98	Acidosis, Respiratory	9.9%
99	Adiposis Dolorosa	9.9%
100	Alkalosis, Respiratory	9.9%
101	Hepatic Encephalopathy	9.8%
102	Tay-Sachs Disease	9.8%
103	Nesidioblastosis	9.8%
104	Alkaptonuria	9.8%
105	Glycogen Storage Disease	9.8%
106	Hypophosphatasia	9.8%
107	Insulin Resistance	9.8%
108	Osteoporosis, Postmenopausal	9.8%
109	Propionic acidemia	9.8%
110	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
111	Cystinosis	9.8%
112	Amyloid Neuropathies, Familial	9.8%
113	Renal tubular acidosis	9.7%
114	Niemann-Pick Disease, Type C	9.3%
115	Neuronal Ceroid-Lipofuscinoses	9%
116	HIV Wasting Syndrome	8.8%
117	Fabry Disease	8.5%
118	HIV-Associated Lipodystrophy Syndrome	8.4%
119	MELAS Syndrome	8.2%
120	Renal Osteodystrophy	8.2%
121	Renal rickets	8.2%
122	Porphyrias, Hepatic	8.1%
123	Glycogen Storage Disease Type I	8.1%
124	Glycogen Storage Disease Type V	8.1%
125	Zellweger Syndrome	8%
126	Mucopolysaccharidosis III	8%
127	Adrenoleukodystrophy	8%
128	Necrobiosis Lipoidica Diabeticorum	7.9%
129	Menkes Kinky Hair Syndrome	7.9%
130	Fanconi Anemia	7.8%
131	Wernicke Encephalopathy	7.7%
132	Gestational Diabetes	7.7%
133	Latent Autoimmune Diabetes in Adults	7.7%
134	Diabetes Mellitus, Experimental	7.6%
135	Hepatolenticular Degeneration	7.4%
136	Nephrocalcinosis	7.4%
137	Tetany	7.4%
138	Refsum Disease	7.3%
139	Glycosuria, Renal	7.3%
140	Cerebral Amyloid Angiopathy	7.2%
141	Deficiency Diseases	6.7%
142	Starvation	6.7%
143	Refeeding Syndrome	6.7%
144	Friedreich Ataxia	6.5%
145	Familial Periodic Paralysis	6%
146	Primary amyloidosis	6%
147	Variegate Porphyria	5.9%
148	Acute intermittent porphyria	5.9%
149	Porphyria Cutanea Tarda	5.9%
150	Renal Aminoacidurias	5.8%
151	Fanconi Syndrome	5.8%
152	Pseudohypoaldosteronism	5.8%
153	Liddle Syndrome	5.8%
154	Kernicterus	5.7%
155	Kearns-Sayre syndrome	5.7%
156	Cockayne Syndrome	5.7%
157	Canavan Disease	5.4%
158	Alexander Disease	5.4%
159	Sjogren-Larsson Syndrome	5.4%
160	Mucopolysaccharidosis II	5.3%
161	Ataxia Telangiectasia	5.1%
162	Gout	5%
163	Amyotrophic Lateral Sclerosis	5%
164	Kwashiorkor	4.9%
165	Magnesium Deficiency	4.9%
166	Potassium Deficiency	4.9%
167	Protein Deficiency	4.9%
168	Avitaminosis	4.9%
169	Optic Atrophy, Hereditary, Leber	4.9%
170	Antley-Bixler Syndrome Phenotype	4.9%
171	Hypokalemic periodic paralysis	4.9%
172	Frontotemporal dementia	4.8%
173	Cystinuria	4.8%
174	Xeroderma Pigmentosum	4.5%
175	CREST Syndrome	4.2%
176	Ascorbic Acid Deficiency	4.1%
177	Vitamin A Deficiency	4.1%
178	Vitamin D Deficiency	4.1%
179	Vitamin E Deficiency	4.1%
180	Marasmus	4.1%
181	Arthritis, Gouty	4.1%
182	Albinism	3.7%
183	Folic Acid Deficiency	3.6%
184	Pellagra	3.6%
185	Thiamine Deficiency	3.6%
186	Vitamin B 12 Deficiency	3.6%
187	Vitamin B 6 Deficiency	3.6%
188	Pyridoxine Deficiency	3.6%
189	Beriberi	3.4%
190	Ichthyosis, X-Linked	3%
191	Obesity	2.6%
192	Obesity, Abdominal	2.4%
193	Anemia, Pernicious	2.3%
194	Vitamin K Deficiency	2.1%
195	Pediatric Obesity	1.9%
196	Scurvy	1.8%
197	Prader-Willi Syndrome	1.6%
198	Subacute Combined Degeneration	1.2%

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