MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Marfan Syndrome

(UMLS:C0024796)

Definition:: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
UMLS ID:: C0024796
MeSH ID:: D008382

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.674

Classification 2:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.240.400.725|C14.280.400.725

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.550|C16.131.240.400.720|C16.320.540

Classification 4:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.500

Synonym(s)

Marfan Syndrome

MARFAN SYNDROME

MARFAN'S SYNDROME

Marfan

Marfan syndrome

Marfan's Syndrome

Marfan's disease

Marfan's syndrome

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Atenolol	19430350	CTD
2	Doxycycline	18178469	CTD
3	Losartan	19430350	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Dextrocardia	41.2%
2	Noonan Syndrome	40.3%
3	Tricuspid Atresia	37.8%
4	Arrhythmogenic Right Ventricular Dysplasia	37.8%
5	Kartagener Syndrome	37.3%
6	Aortic coarctation	36.2%
7	Cor Triatriatum	36.2%
8	Coronary Vessel Anomalies	36.2%
9	Patent ductus arteriosus	36.2%
10	Ebstein Anomaly	36.2%
11	Heart Septal Defects	36.2%
12	Tetralogy of Fallot	36.2%
13	Transposition of Great Vessels	36.2%
14	Hypoplastic Left Heart Syndrome	36.2%
15	Rubinstein-Taybi Syndrome	33.3%
16	Holoprosencephaly	33.2%
17	Beckwith-Wiedemann Syndrome	32%
18	Wolf-Hirschhorn Syndrome	32%
19	Ectodermal Dysplasia	30%
20	Aplasia Cutis Congenita	30%
21	Cockayne Syndrome	29.4%
22	Smith-Magenis syndrome	29.2%
23	Cri-du-Chat Syndrome	29%
24	Down Syndrome	29%
25	Trisomy 21	29%
26	Aicardi's syndrome	28.9%
27	Turner Syndrome	28.6%
28	Ectopia Cordis	28.4%
29	Nail-Patella Syndrome	27.9%
30	Aortopulmonary Septal Defect	27.5%
31	Double Outlet Right Ventricle	27.5%
32	Endocardial Cushion Defects	27.5%
33	Myocardial bridging	27.5%
34	Aorticopulmonary Septal Defect	27.5%
35	Prader-Willi Syndrome	26.5%
36	CHARGE Syndrome	26.4%
37	Osteogenesis Imperfecta	25%
38	Ichthyosis, X-Linked	24.7%
39	Alstrom Syndrome	24.2%
40	Pectus carinatum	24.1%
41	Multiple Epiphyseal Dysplasia	23.8%
42	Osteochondrodysplasias	23.8%
43	Long QT Syndrome	23.2%
44	Truncus Arteriosus, Persistent	23.1%
45	Pseudoxanthoma Elasticum	23.1%
46	Wolff-Parkinson-White Syndrome	22.7%
47	Fragile X Syndrome	22.1%
48	Dwarfism	21.8%
49	Dural Arteriovenous Fistula	21.8%
50	Scimitar Syndrome	21.7%
51	Smith-Lemli-Opitz Syndrome	21.2%
52	Acrocephalosyndactylia	21%
53	Pectus excavatum	20.7%
54	Polycystic Kidney Diseases	20.6%
55	Basal Cell Nevus Syndrome	20.6%
56	Mucopolysaccharidosis II	19.7%
57	Epidermolysis Bullosa	19.6%
58	Platybasia	19.5%
59	Albinism	19.4%
60	Mobius Syndrome	19.1%
61	Sjogren-Larsson Syndrome	18.9%
62	Williams Syndrome	18.8%
63	Cutis Laxa	18.6%
64	Skin Abnormalities	18.6%
65	Klippel-Feil Syndrome	18.2%
66	Synostosis	18.2%
67	Craniosynostosis	18.2%
68	Syndactyly	18.2%
69	Brachycephaly	18.2%
70	Prune Belly Syndrome	18.1%
71	Waardenburg Syndrome	18.1%
72	Primary Ciliary Dyskinesia	18%
73	Xeroderma	17.8%
74	Romano-Ward Syndrome	17.6%
75	May-Thurner Syndrome	17.4%
76	Abnormalities, Drug-Induced	17.4%
77	Situs Inversus	17.4%
78	Xeroderma Pigmentosum	17.1%
79	Antley-Bixler Syndrome Phenotype	17%
80	Cystic Fibrosis	16.9%
81	Menkes Kinky Hair Syndrome	16.6%
82	Single umbilical artery	16.4%
83	Congenital Hypothyroidism	16.3%
84	Zellweger Syndrome	16.2%
85	Bloom Syndrome	16.1%
86	Muscular Dystrophy, Duchenne	16.1%
87	Arteriovenous fistula	16%
88	Eye Abnormalities	15.8%
89	Anencephaly	15.8%
90	Polycystic Kidney, Autosomal Dominant	15.7%
91	Maxillofacial Abnormalities	15.6%
92	Lymphatic Abnormalities	15.6%
93	Congenital Microtia	15.6%
94	Congenital diaphragmatic hernia	15.4%
95	Hyperkeratosis, Epidermolytic	15.3%
96	Anemia, Sickle Cell	15.2%
97	Thalassemia	15.2%
98	Poland Syndrome	15.1%
99	Craniofacial Dysostosis	15.1%
100	Retinal Dysplasia	14.8%
101	Aniridia	14.7%
102	Refsum Disease	14.6%
103	Homocystinuria	14.6%
104	Laryngomalacia	14.5%
105	Angioedemas, Hereditary	14.5%
106	Osteochondritis	14.3%
107	Urogenital Abnormalities	14.3%
108	Tuberous Sclerosis	14.1%
109	Classical Lissencephalies and Subcortical Band Heterotopias	14.1%
110	Arthrogryposis	14%
111	Cardiovascular Abnormalities	13.9%
112	Adrenoleukodystrophy	13.8%
113	Mucopolysaccharidosis III	13.7%
114	Myocardial Ischemia	13.7%
115	Fabry Disease	13.6%
116	Myotonic Dystrophy	13.6%
117	Neoplastic Syndromes, Hereditary	13.5%
118	Gigantism	13.5%
119	Myocardial Reperfusion Injury	13.4%
120	Panniculitis, Lupus Erythematosus	13.4%
121	Rett Syndrome	13.3%
122	Pelger-Huet Anomaly	13.2%
123	Werner Syndrome	13.2%
124	Myasthenic Syndromes, Congenital	13.2%
125	Kallmann Syndrome	13.2%
126	Muscular Dystrophy	13.2%
127	Acrodermatitis	13.1%
128	Gianotti-Crosti Syndrome	13.1%
129	Cartilage Diseases	13.1%
130	Rheumatism	13.1%
131	Chondromalacia	13.1%
132	POEMS Syndrome	13.1%
133	Wiskott-Aldrich Syndrome	12.8%
134	Porokeratosis	12.5%
135	Keratoderma, Palmoplantar	12.5%
136	Limb Deformities, Congenital	12.5%
137	Craniofacial Abnormalities	12.5%
138	Microcephaly	12.3%
139	Macrocephaly	12.3%
140	Lupus Erythematosus, Cutaneous	12.2%
141	Panniculitis	12.2%
142	Systemic Scleroderma	12.2%
143	Morphea	12.2%
144	Sickle Cell Trait	12.1%
145	Dermatitis, Atopic	12%
146	Aortic Valve Stenosis	12%
147	Cardiomyopathy, Dilated	12%
148	Pulmonary Valve Stenosis	12%
149	Hepatolenticular Degeneration	12%
150	Fetal Diseases	12%
151	Cleft Palate	11.9%
152	Klinefelter Syndrome	11.9%
153	Bronchomalacia	11.9%
154	Tracheomalacia	11.9%
155	Dysostoses	11.8%
156	Neuronal Ceroid-Lipofuscinoses	11.8%
157	Jaw Abnormalities	11.8%
158	Marfan Syndrome	11.6%
159	Abnormalities, Radiation-Induced	11.5%
160	Glycogen storage disease type II	11.4%
161	Twins, Conjoined	11.4%
162	Behcet Syndrome	11.4%
163	Mandibulofacial Dysostosis	11.2%
164	Gastroschisis	11.1%
165	Charcot-Marie-Tooth Disease	11.1%
166	Goldenhar Syndrome	10.9%
167	Porencephaly	10.8%
168	Autoimmune Lymphoproliferative Syndrome	10.8%
169	Meconium Aspiration Syndrome	10.8%
170	Heart Block	10.8%
171	Tachycardia	10.8%
172	Tachyarrhythmia	10.8%
173	Dermatomyositis	10.8%
174	Amyloid Neuropathies, Familial	10.6%
175	Familial Mediterranean Fever	10.5%
176	Ataxia Telangiectasia	10.4%
177	Acute Chest Syndrome	10.3%
178	Polymyalgia Rheumatica	10.2%
179	Cardiac Tamponade	10.2%
180	Collagen Diseases	10.2%
181	Endocarditis	10.2%
182	Cardiac Arrest	10.2%
183	Heart failure	10.2%
184	Mixed Connective Tissue Disease	10.2%
185	Pericardial effusion	10.2%
186	Pericarditis	10.2%
187	Pneumopericardium	10.2%
188	Cor pulmonale	10.2%
189	Ventricular Outflow Obstruction	10.2%
190	Mucinoses	10.2%
191	Ventricular Dysfunction	10.2%
192	Cardiomyopathies	10.2%
193	Pleuropericarditis	10.2%
194	Anophthalmos	10.2%
195	Anus, Imperforate	10.2%
196	Hydranencephaly	10.2%
197	Microphthalmos	10.2%
198	Neural Tube Defects	10.2%
199	Tethered Cord Syndrome	10.2%
200	Iniencephaly	10.2%
201	Craniorachischisis	10.2%
202	Exencephaly	10.2%
203	Septo-Optic Dysplasia	10.2%
204	Cortical Dysplasia	10.2%
205	Malformations of Cortical Development	10.2%
206	Anorectal Malformations	10.2%
207	Galactosemias	10.2%
208	Urea Cycle Disorders, Inborn	10.2%
209	Tyrosinemias	10.2%
210	Papillon-Lefevre Disease	10%
211	Sick Sinus Syndrome	9.9%
212	Gaucher Disease	9.9%
213	Hypertrophic Cardiomyopathy	9.7%
214	Hypertrophic obstructive cardiomyopathy	9.7%
215	Micrognathism	9.6%
216	Pierre Robin Syndrome	9.6%
217	Porphyrias, Hepatic	9.5%
218	Gout	9.5%
219	Optic Atrophy, Hereditary, Leber	9.5%
220	Dupuytren Contracture	9.4%
221	Hyperphosphaturia	9.4%
222	Amino Acid Metabolism, Inborn Errors	9.4%
223	Carbohydrate Metabolism, Inborn Errors	9.4%
224	Metal Metabolism, Inborn Errors	9.4%
225	Progeria	9.4%
226	Lysosomal Storage Diseases	9.4%
227	Cytochrome-c Oxidase Deficiency	9.4%
228	Peroxisomal Disorders	9.4%
229	Welander Distal Myopathy	9.3%
230	Canavan Disease	9.3%
231	Alexander Disease	9.3%
232	Tay-Sachs Disease	9.3%
233	Prognathism	9.2%
234	Blepharophimosis	9.2%
235	Laryngostenosis	9.2%
236	Mouth Abnormalities	9.2%
237	Esophageal Atresia	9.2%
238	Intestinal Atresia	9.2%
239	Horseshoe Kidney	9.2%
240	Lupus Erythematosus, Systemic	9.1%
241	Osteoarthropathy, Secondary Hypertrophic	9.1%
242	Cardiac Output, High	9.1%
243	Myocardial Stunning	9.1%
244	Overlap syndrome	9.1%
245	Low Cardiac Output Syndrome	9.1%
246	Lymphangiectasis, Intestinal	9.1%
247	Cardiomegaly	9.1%
248	Postpericardiotomy Syndrome	9.1%
249	Tietze's Syndrome	9.1%
250	Cardiac Hypertrophy	9.1%
251	Rheumatic Heart Disease	9%
252	Coronary heart disease	9%
253	Lupus Erythematosus, Discoid	9%
254	Myocardial Infarction	9%
255	Scleroderma, Limited	9%
256	Acute Coronary Syndrome	9%
257	Amelia	9%
258	Arachnodactyly	9%
259	Ectromelia	9%
260	Hemimelia	9%
261	Phocomelia	9%
262	Sirenomelia	9%
263	Polydactyly	9%
264	Brachydactyly	9%
265	Plagiocephaly	9%
266	Lower Extremity Deformities, Congenital	9%
267	Upper Extremity Deformities, Congenital	9%
268	Retrognathia	8.9%
269	Peutz-Jeghers Syndrome	8.9%
270	Niemann-Pick Disease, Type C	8.9%
271	Supravalvular aortic stenosis	8.9%
272	Lown-Ganong-Levine Syndrome	8.9%
273	Pseudohypoparathyroidism	8.9%
274	Myotonia Congenita	8.8%
275	Leigh Disease	8.8%
276	Chondrodysplasia Punctata	8.8%
277	Enchondromatosis	8.8%
278	Osteosclerosis	8.8%
279	Kashin-Beck Disease	8.8%
280	Coronary Aneurysm	8.7%
281	Rheumatoid Arthritis	8.7%
282	Bacterial Endocarditis	8.7%
283	Juvenile arthritis	8.7%
284	CREST Syndrome	8.7%
285	Vascular Diseases	8.7%
286	Retinitis Pigmentosa	8.4%
287	Pigmentary retinopathy	8.4%
288	Choanal Atresia	8.4%
289	Tracheobronchomegaly	8.4%
290	Laryngocele	8.4%
291	Chronic granulomatous disease	8.4%
292	Choledochal Cyst	8.4%
293	Hermaphroditism	8.4%
294	Disorders of Sex Development	8.4%
295	Cryptorchidism	8.3%
296	Hypospadias	8.3%
297	Central Nervous System Cysts	8.3%
298	Dandy-Walker Syndrome	8.3%
299	Necrobiosis Lipoidica Diabeticorum	8.2%
300	Genetic Diseases, Inborn	8.2%
301	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.2%
302	Erythema Induratum	8.2%
303	Kounis Syndrome	8.1%
304	Abdominal Cramps	8.1%
305	Amniotic Band Syndrome	8.1%
306	Asphyxia Neonatorum	8.1%
307	Infant, Premature, Diseases	8.1%
308	Infantile Colic	8.1%
309	Spinal Neoplasms	8.1%
310	Spondylitis	8.1%
311	Angina Pectoris	8%
312	Adams-Stokes Syndrome	8%
313	Atrioventricular Block	8%
314	Bundle-Branch Block	8%
315	Coronary Thrombosis	8%
316	Atrial Premature Complexes	8%
317	Sinoatrial Block	8%
318	Tachycardia, Paroxysmal	8%
319	Supraventricular tachycardia	8%
320	Tachycardia, Ventricular	8%
321	Tachycardia, Reciprocating	8%
322	Coronary Artery Disease	8%
323	Familial Periodic Paralysis	8%
324	Rheumatoid Vasculitis	7.8%
325	Duane Retraction Syndrome	7.7%
326	Pregnancy Complications, Cardiovascular	7.7%
327	Hyperostosis	7.7%
328	Osteitis	7.7%
329	Osteitis Deformans	7.7%
330	Osteochondrosis	7.7%
331	Spinal Diseases	7.7%
332	Talipes	7.6%
333	Thrombasthenia	7.6%
334	Antithrombin III Deficiency	7.6%
335	Protein C Deficiency	7.6%
336	Brain Diseases, Metabolic, Inborn	7.6%
337	Afibrinogenemia	7.6%
338	Dystonia Musculorum Deformans	7.6%
339	Factor VII Deficiency	7.6%
340	Factor X Deficiency	7.6%
341	Factor XII Deficiency	7.6%
342	Hemophilia A	7.6%
343	Activated Protein C Resistance	7.6%
344	Factor II deficiency	7.6%
345	Factor VIII Deficiency	7.6%
346	Factor V deficiency	7.6%
347	Factor XI Deficiency	7.6%
348	Hypoprothrombinemias	7.6%
349	Arthritis, Gouty	7.6%
350	Scleromyxedema	7.6%
351	Bladder Exstrophy	7.6%
352	Epispadias	7.6%
353	Fanconi Anemia	7.6%
354	Variegate Porphyria	7.6%
355	Acute intermittent porphyria	7.6%
356	Porphyria Cutanea Tarda	7.6%
357	Lafora Disease	7.6%
358	Unverricht-Lundborg Syndrome	7.6%
359	Anemia, Diamond-Blackfan	7.6%
360	Multicystic Dysplastic Kidney	7.6%
361	Meningomyelocele	7.5%
362	Spina Bifida	7.5%
363	Alkaptonuria	7.4%
364	Glycogen Storage Disease	7.4%
365	Hypophosphatasia	7.4%
366	Propionic acidemia	7.4%
367	Dihydropyrimidine Dehydrogenase Deficiency	7.4%
368	Cystinosis	7.4%
369	Malignant Atrophic Papulosis	7.4%
370	Cellulitis	7.4%
371	Rheumatoid Nodule	7.4%
372	Melorheostosis	7.3%
373	Osteopetrosis	7.3%
374	Hydrops Fetalis	7.3%
375	Carcinoid Heart Disease	7.3%
376	Familial Hypophosphatemic Rickets	7.3%
377	Hyperandrogenism	7.2%
378	Anemia, Neonatal	7.2%
379	Persistent Fetal Circulation Syndrome	7.2%
380	Umbilical hernia	7.1%
381	Multiple Endocrine Neoplasia	7.1%
382	Granuloma Annulare	7%
383	Bone Diseases, Endocrine	6.9%
384	Foot Diseases	6.9%
385	Bone Diseases, Infectious	6.8%
386	Bone neoplasms	6.8%
387	Compartment syndromes	6.8%
388	Osteopenia	6.8%
389	Bone Resorption	6.8%
390	Mesenteric Panniculitis	6.8%
391	Panniculitis, Peritoneal	6.8%
392	Orbital Cellulitis	6.8%
393	Aseptic Necrosis of Bone	6.8%
394	Myxoid cyst	6.8%
395	Aortic Valve Insufficiency	6.8%
396	Restrictive cardiomyopathy	6.8%
397	Endocardial Fibroelastosis	6.8%
398	Heart Rupture, Post-Infarction	6.8%
399	Mitral Valve Insufficiency	6.8%
400	Mitral Valve Stenosis	6.8%
401	Myocarditis	6.8%
402	Pericarditis, Constrictive	6.8%
403	Pulmonary Valve Insufficiency	6.8%
404	Tricuspid Valve Insufficiency	6.8%
405	Tricuspid Valve Stenosis	6.8%
406	Ventricular Dysfunction, Left	6.8%
407	Right Ventricular Dysfunction	6.8%
408	Endomyocardial Fibrosis	6.8%
409	Carditis	6.8%
410	Heart Failure, Systolic	6.8%
411	Heart Failure, Diastolic	6.8%
412	Myxedema	6.7%
413	Dental Enamel Hypoplasia	6.7%
414	Hypodontia	6.7%
415	Macrostomia	6.7%
416	Meningocele	6.7%
417	Microstomia	6.7%
418	Encephalocele	6.7%
419	Coronary Occlusion	6.7%
420	Microvascular Angina	6.7%
421	Coronary Stenosis	6.7%
422	ST segment elevation myocardial infarction	6.7%
423	Felty Syndrome	6.7%
424	Hypolipoproteinemias	6.7%
425	Hyperlipidemia, Familial Combined	6.7%
426	Congenital clubfoot	6.7%
427	Vertical Talus	6.7%
428	Hyperlipoproteinemia Type III	6.7%
429	Tachycardia, Atrioventricular Nodal Reentry	6.6%
430	Tachycardia, Ectopic Atrial	6.6%
431	Tachycardia, Ectopic Junctional	6.6%
432	Sinus Tachycardia	6.6%
433	Torsades de Pointes	6.6%
434	Accelerated Idioventricular Rhythm	6.6%
435	Neonatal Abstinence Syndrome	6.5%
436	Hypokalemic periodic paralysis	6.5%
437	Glycogen Storage Disease Type I	6.5%
438	Glycogen Storage Disease Type V	6.5%
439	Fetal Growth Retardation	6.4%
440	Fetal Hypoxia	6.4%
441	Congenital nystagmus	6.4%
442	Fetal Alcohol Spectrum Disorders	6.4%
443	Toxoplasmosis, Congenital	6.4%
444	Leukomalacia, Periventricular	6.4%
445	Syphilis, Congenital	6.4%
446	Denys-Drash Syndrome	6.3%
447	Dermal Sinus	6.1%
448	Spina Bifida Cystica	6.1%
449	Spina Bifida Occulta	6.1%
450	Lissencephaly	6.1%
451	Polymicrogyria	6.1%
452	Pachygyria	6.1%
453	Schizencephaly	6.1%
454	Periventricular Nodular Heterotopia	6.1%
455	Ischemic contracture	6.1%
456	Embolism, Amniotic Fluid	6.1%
457	Gonadal Dysgenesis	6.1%
458	Adrenogenital Syndrome	6.1%
459	Ovotesticular Disorders of Sex Development	6.1%
460	Lactose Intolerance	6.1%
461	Pyoderma Gangrenosum	6.1%
462	Hyperhomocysteinemia	6%
463	Renal Aminoacidurias	6%
464	Fanconi Syndrome	6%
465	Pseudohypoaldosteronism	6%
466	Liddle Syndrome	6%
467	Keloid	6%
468	Polyarteritis Nodosa	6%
469	Shock, Cardiogenic	6%
470	Takayasu Arteritis	6%
471	Hyperlipoproteinemia Type IV	6%
472	Hyperlipoproteinemia Type V	6%
473	Discitis	6%
474	Aortic Aneurysm	6%
475	Aortitis	6%
476	Sinus Arrhythmia	6%
477	Atrial Fibrillation	6%
478	Atrial Flutter	6%
479	Edema, Cardiac	6%
480	Leriche Syndrome	6%
481	Periphlebitis	6%
482	Phlebitis	6%
483	Thromboangiitis Obliterans	6%
484	Ventricular Fibrillation	6%
485	Ventricular Flutter	6%
486	Parasystole	6%
487	Paroxysmal atrial fibrillation	6%
488	Bradycardia	6%
489	Diabetic Cardiomyopathies	6%
490	Angina, Unstable	6%
491	Cardiomyopathy, Alcoholic	6%
492	Sudden Cardiac Death	6%
493	Left Ventricular Hypertrophy	6%
494	Right Ventricular Hypertrophy	6%
495	Chagas Cardiomyopathy	6%
496	Huntington Disease	5.9%
497	MELAS Syndrome	5.9%
498	Congenital Hyperinsulinism	5.8%
499	Chorioamnionitis	5.8%
500	Hypoalphalipoproteinemias	5.8%
501	Retinal Vein Occlusion	5.8%
502	Angioedema	5.7%
503	Giant Cell Arteritis	5.7%
504	Temporal Arteritis	5.7%
505	Thrombophlebitis	5.7%
506	Sicca Syndrome	5.6%
507	Sjogren's Syndrome	5.6%
508	Multiple Endocrine Neoplasia Type 1	5.6%
509	Subacute Bacterial Endocarditis	5.6%
510	Coronary Restenosis	5.6%
511	Nephroblastoma	5.5%
512	Friedreich Ataxia	5.5%
513	Renal tubular acidosis	5.5%
514	Arthritis, Psoriatic	5.5%
515	Lupus Vasculitis, Central Nervous System	5.5%
516	Aortic Rupture	5.5%
517	Lupus Nephritis	5.5%
518	Tuberculosis, Spinal	5.4%
519	Dyspnea, Paroxysmal	5.4%
520	Shwartzman Phenomenon	5.4%
521	Osteoarthritis, Spine	5.3%
522	Cystinuria	5.3%
523	Moyamoya Disease	5.2%
524	Postphlebitic Syndrome	5.2%
525	Deformity	5.2%
526	Adenomatous Polyposis Coli	5.2%
527	Carotid Artery Thrombosis	5.1%
528	Aneurysm	5.1%
529	Angiomatosis	5.1%
530	Aortic Diseases	5.1%
531	Arterial Occlusive Diseases	5.1%
532	Hyperemia	5.1%
533	Hypotension	5.1%
534	Superior Vena Cava Syndrome	5.1%
535	Telangiectasis	5.1%
536	Vasculitis	5.1%
537	Venous Insufficiency	5.1%
538	Peripheral Vascular Diseases	5.1%
539	Embolism and Thrombosis	5.1%
540	Angiodysplasia	5.1%
541	Capillary Leak Syndrome	5.1%
542	Prehypertension	5.1%
543	Ainhum	5.1%
544	Spinal Stenosis	5.1%
545	Spondylosis	5.1%
546	Intervertebral Disc Degeneration	5.1%
547	Aortic Valve Prolapse	5%
548	Tricuspid Valve Prolapse	5%
549	Takotsubo Cardiomyopathy	5%
550	Eosinophilic Granuloma	5%
551	Dermatitis, Phototoxic	5%
552	Pityriasis Lichenoides et Varioliformis Acuta	5%
553	Pityriasis Lichenoides	5%
554	Phototoxicity	5%
555	Angina Pectoris, Variant	5%
556	Paralysis, Obstetric	4.9%
557	Retinopathy of Prematurity	4.9%
558	Ophthalmia Neonatorum	4.9%
559	Bronchopulmonary Dysplasia	4.9%
560	Varicose Ulcer	4.9%
561	Mucocutaneous Lymph Node Syndrome	4.7%
562	Livedo Reticularis	4.7%
563	Glycosuria, Renal	4.7%
564	Intracranial Embolism and Thrombosis	4.7%
565	Carotid Stenosis	4.7%
566	Intracranial Aneurysm	4.7%
567	Blue Toe Syndrome	4.7%
568	Vascular System Injuries	4.6%
569	Contracture	4.6%
570	Hepatic Veno-Occlusive Disease	4.6%
571	Peliosis Hepatis	4.6%
572	Varicocele	4.6%
573	Fasciitis, Plantar	4.6%
574	Dermatitis, Photoallergic	4.5%
575	Cerebrovascular Disorders	4.5%
576	Diabetic Angiopathies	4.5%
577	Reperfusion Injury	4.5%
578	Splenic Infarction	4.5%
579	Cerebrovascular Insufficiency	4.5%
580	Vascular Neoplasms	4.5%
581	Spinal Cord Vascular Diseases	4.5%
582	Vasoplegia	4.5%
583	Hemorrhoids	4.5%
584	Thoracic Outlet Syndrome	4.5%
585	Acne Vulgaris	4.5%
586	Anterior Compartment Syndrome	4.5%
587	Contact Dermatitis	4.5%
588	Eczema	4.5%
589	Erythema Multiforme	4.5%
590	Intertrigo	4.5%
591	Neurodermatitis	4.5%
592	Osteomyelitis	4.5%
593	Osteoporosis	4.5%
594	Periostitis	4.5%
595	Rhinophyma	4.5%
596	Bone Demineralization, Pathologic	4.5%
597	Perioral Dermatitis	4.5%
598	Acne	4.5%
599	Post-Traumatic Osteoporosis	4.5%
600	Vasculitis, Central Nervous System	4.5%
601	Abdominal Compartment Syndrome	4.5%
602	Alveolar Bone Loss	4.5%
603	Femur Head Necrosis	4.5%
604	Osteolysis	4.5%
605	Aortic Aneurysm, Abdominal	4.5%
606	Aortic Aneurysm, Thoracic	4.5%
607	Sinus Arrest, Cardiac	4.5%
608	Respiratory Distress Syndrome, Newborn	4.4%
609	Ankylosing spondylitis	4.4%
610	Fasciitis	4.3%
611	Foot Deformities	4.3%
612	Heart Diseases	4.3%
613	Arthropathy	4.3%
614	Hand-Arm Vibration Syndrome	4.2%
615	Foot Ulcer	4.1%
616	Fibromyalgia	4.1%
617	Optic Neuropathy, Ischemic	4.1%
618	Anterior Ischemic Optic Neuropathy	4.1%
619	Mesenteric vascular insufficiency	4.1%
620	Metatarsalgia	4.1%
621	Dermatitis Herpetiformis	4.1%
622	Sebaceous Gland Neoplasms	4%
623	Colitis, Ischemic	4%
624	Acromegaly	4%
625	Joint Tuberculosis	4%
626	Tuberculosis, Osteoarticular	4%
627	Bone Tuberculosis	4%
628	Intracranial Arteriosclerosis	4%
629	Cerebral Atherosclerosis	4%
630	Cerebral Arteriosclerosis	4%
631	Nesidioblastosis	3.9%
632	Jaw Diseases	3.9%
633	Spondylarthropathies	3.9%
634	Myopathy	3.9%
635	Toxic Epidermal Necrolysis	3.8%
636	Stevens-Johnson Syndrome	3.8%
637	Diabetic Foot	3.8%
638	Lordosis	3.8%
639	Spondylolysis	3.8%
640	kyphosis	3.8%
641	Subarachnoid Hemorrhage, Traumatic	3.8%
642	Carotid Artery, Internal, Dissection	3.8%
643	Lemierre Syndrome	3.7%
644	Dermatitis, Irritant	3.7%
645	Acne Conglobata	3.7%
646	Temporomandibular Joint Disorders	3.7%
647	Arthritis, Reactive	3.7%
648	Urticaria Pigmentosa	3.7%
649	Kearns-Sayre syndrome	3.7%
650	Cerebral Thrombosis	3.7%
651	Intracranial Embolism	3.7%
652	Intracranial Thrombosis	3.7%
653	Rickets	3.7%
654	Brain Infarction	3.6%
655	Infarction, Middle Cerebral Artery	3.5%
656	Infarction, Anterior Cerebral Artery	3.5%
657	Infarction, Posterior Cerebral Artery	3.5%
658	Temporomandibular Joint Dysfunction Syndrome	3.5%
659	Dermatitis, Occupational	3.4%
660	Breast Diseases	3.4%
661	Dermatitis	3.4%
662	Exanthema	3.4%
663	Facial Dermatoses	3.4%
664	Hair Diseases	3.4%
665	Hand Dermatoses	3.4%
666	keratoacanthoma	3.4%
667	Keratosis	3.4%
668	Nail Diseases	3.4%
669	Photosensitivity Disorders	3.4%
670	Prurigo	3.4%
671	Pyoderma	3.4%
672	Rosacea	3.4%
673	Sebaceous Gland Diseases	3.4%
674	Skin Diseases, Vesiculobullous	3.4%
675	Skin Ulcer	3.4%
676	Sweat Gland Diseases	3.4%
677	Skin Diseases, Papulosquamous	3.4%
678	Skin Diseases, Vascular	3.4%
679	Acneiform Eruptions	3.4%
680	Ocular Rosacea	3.4%
681	Subcorneal pustular dermatosis	3.4%
682	Erythematotelangiectatic Rosacea	3.4%
683	Papulopustular Rosacea	3.4%
684	Chronic Actinic Dermatitis	3.4%
685	Hereditary Angioedema Type III	3.4%
686	Hereditary Angioedema Types I and II	3.4%
687	Rheumatic Fever	3.4%
688	Aneurysm, Dissecting	3.4%
689	Arteriosclerosis	3.4%
690	Arteritis	3.4%
691	Embolism	3.4%
692	Erythromelalgia	3.4%
693	Fibromuscular Dysplasia	3.4%
694	Malignant Hypertension	3.4%
695	Raynaud Disease	3.4%
696	Thromboembolism	3.4%
697	Thrombosis	3.4%
698	Essential Hypertension	3.4%
699	Aneurysm, Ruptured	3.4%
700	Iliac Aneurysm	3.4%
701	Pulmonary artery stenosis	3.4%
702	White Coat Hypertension	3.4%
703	Systemic Vasculitis	3.4%
704	Embolus	3.4%
705	Erythema Infectiosum	3.4%
706	Kernicterus	3.4%
707	Exanthema Subitum	3.4%
708	Hyaline Membrane Disease	3.4%
709	Osteoporosis, Postmenopausal	3.3%
710	Dermatitis, Allergic Contact	3.3%
711	Diaper Rash	3.3%
712	Erythema Nodosum	3.3%
713	Vertebral Artery Dissection	3.3%
714	Tinea Capitis	3.2%
715	Onychomycosis	3.2%
716	Sinus Thrombosis, Intracranial	3.1%
717	Spondylolisthesis	3.1%
718	Carotid Artery Injuries	3.1%
719	Ecthyma	3.1%
720	Skin Diseases, Infectious	3%
721	Skin Neoplasms	3%
722	Pigmentation Disorders	3%
723	Lipomatosis	3%
724	Pruritus	3%
725	Retinal Artery Occlusion	3%
726	Erythema	3%
727	Retinal Vasculitis	3%
728	Hypertensive Retinopathy	3%
729	Necrolytic Migratory Erythema	3%
730	Cutaneous Fistula	3%
731	Nephrogenic Fibrosing Dermopathy	3%
732	Nephrogenic Systemic Fibrosis	3%
733	Mastoiditis	3%
734	Petrositis	3%
735	Cerebral Infarction	3%
736	Brain Stem Infarctions	3%
737	Hip Contracture	3%
738	Periarthritis	3%
739	Vasculitis, Leukocytoclastic, Cutaneous	3%
740	Gastric Antral Vascular Ectasia	3%
741	Carotid Artery Diseases	3%
742	Brain Ischemia	3%
743	Hypotension, Orthostatic	3%
744	Cerebrovascular accident	3%
745	Vasospasm, Intracranial	3%
746	Spinal Cord Ischemia	3%
747	Intracranial Arterial Diseases	3%
748	Primary Graft Dysfunction	3%
749	Post-Exercise Hypotension	3%
750	Palatal Neoplasms	2.9%
751	Cavernous Sinus Thrombosis	2.9%
752	Sagittal Sinus Thrombosis	2.9%
753	Basal Ganglia Hemorrhage	2.8%
754	Hidradenitis Suppurativa	2.8%
755	Mesenteric Vascular Occlusion	2.7%
756	Osteomalacia	2.7%
757	Diabetic Retinopathy	2.7%
758	Mastocytosis	2.7%
759	Sturge-Weber Syndrome	2.7%
760	Lateral Medullary Syndrome	2.7%
761	Renal hypertension	2.7%
762	Renal Artery Obstruction	2.7%
763	Renal Artery Stenosis	2.7%
764	Hemangioma, Cavernous	2.7%
765	Basal Ganglia Cerebrovascular Disease	2.7%
766	Vascular Headaches	2.7%
767	Scurvy	2.7%
768	Tinea Pedis	2.6%
769	Osteoarthritis, Knee	2.6%
770	Erythema Chronicum Migrans	2.6%
771	Arthritis	2.6%
772	Bursitis	2.6%
773	Joint Instability	2.6%
774	Myofascial Pain Syndromes	2.6%
775	Rhabdomyolysis	2.6%
776	Synovitis	2.6%
777	Joint laxity	2.6%
778	Polyarthritis	2.6%
779	Frozen shoulder	2.6%
780	Patellofemoral Pain Syndrome	2.6%
781	Anhidrosis	2.5%
782	Cholesteatoma	2.5%
783	Pressure Ulcer	2.5%
784	Folliculitis	2.5%
785	Foot Dermatoses	2.5%
786	Gynecomastia	2.5%
787	Hypertrichosis	2.5%
788	Hypohidrosis	2.5%
789	Hypotrichosis	2.5%
790	Leg Ulcer	2.5%
791	Miliaria	2.5%
792	Parakeratosis	2.5%
793	Parapsoriasis	2.5%
794	Pityriasis	2.5%
795	Psoriasis	2.5%
796	Sweet Syndrome	2.5%
797	Hidradenitis	2.5%
798	Onycholysis	2.5%
799	Miliaria Rubra	2.5%
800	Hyperpigmentation	2.5%
801	Lichenoid Eruptions	2.5%
802	Chloracne	2.5%
803	Arteriosclerosis Obliterans	2.5%
804	Atherosclerosis	2.5%
805	Air Embolism	2.5%
806	Endarteritis	2.5%
807	Venous Thrombosis	2.5%
808	Deep Vein Thrombosis	2.5%
809	Venous Thromboembolism	2.5%
810	Cryoglobulinemia	2.4%
811	Putaminal Hemorrhage	2.4%
812	Mycetoma	2.4%
813	Dementia, Vascular	2.4%
814	Maxillary Diseases	2.3%
815	Tendinitis	2.3%
816	Tendinopathy	2.3%
817	Acantholysis	2.3%
818	Breast Cyst	2.3%
819	Hemarthrosis	2.3%
820	Actinic keratosis	2.3%
821	Myositis	2.3%
822	Pemphigoid, Benign Mucous Membrane	2.3%
823	Pemphigus	2.3%
824	Piedra	2.3%
825	Sunburn	2.3%
826	Isaacs syndrome	2.3%
827	Myotonic Disorders	2.3%
828	Intermittent Claudication	2.3%
829	Pulmonary Embolism	2.3%
830	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	2.3%
831	Argyria	2.2%
832	Hirsutism	2.2%
833	Lactation Disorder	2.2%
834	Mastitis	2.2%
835	Urticaria	2.2%
836	Adiposis Dolorosa	2.2%
837	Pruritus Vulvae	2.2%
838	No-Reflow Phenomenon	2.2%
839	Mastocytoma	2.2%
840	Pruritus Ani	2.2%
841	Cerebral Arterial Diseases	2.2%
842	Vertebrobasilar Insufficiency	2.2%
843	Anterior Spinal Artery Syndrome	2.2%
844	Basilar Artery Stenosis	2.2%
845	Vertebral Artery Stenosis	2.2%
846	Intracranial Hemorrhage, Hypertensive	2.2%
847	Transient Cerebral Ischemia	2.2%
848	Shy-Drager Syndrome	2.2%
849	Purpura, Hyperglobulinemic	2.2%
850	Nose Neoplasms	2.2%
851	Renal Osteodystrophy	2.1%
852	Renal rickets	2.1%
853	Lichen Planus	2.1%
854	Melanosis	2.1%
855	Chloasma	2.1%
856	Pityriasis Rosea	2.1%
857	Pityriasis Rubra Pilaris	2.1%
858	Vitiligo	2.1%
859	Lichen Nitidus	2.1%
860	Waldenstrom Macroglobulinemia	2.1%
861	Multiple Myeloma	2.1%
862	Medial Tibial Stress Syndrome	2%
863	Dermatomycoses	2%
864	Skin Diseases, Bacterial	2%
865	Mitochondrial Myopathies	2%
866	Muscle Cramp	2%
867	Eosinophilia-Myalgia Syndrome	2%
868	Drug Eruptions	2%
869	Lipodystrophy	2%
870	Muscle Rigidity	2%
871	Muscle Spasticity	2%
872	Cogwheel Rigidity	2%
873	Nuchal Rigidity	2%
874	Hypertension, Renovascular	2%
875	Subarachnoid Hemorrhage	2%
876	Hypoxia-Ischemia, Brain	2%
877	Cerebral Hemorrhage	2%
878	Chronic Fatigue Syndrome	1.9%
879	Acanthosis Nigricans	1.9%
880	Alopecia Areata	1.9%
881	Lentigo	1.9%
882	Alopecia	1.9%
883	Sweating, Gustatory	1.9%
884	Androgenetic Alopecia	1.9%
885	Auriculotemporal Syndrome	1.9%
886	Hepatic Vein Thrombosis	1.9%
887	Budd-Chiari Syndrome	1.9%
888	Lice Infestations	1.9%
889	Breast Neoplasms, Male	1.9%
890	Triple Negative Breast Neoplasms	1.9%
891	Pulmonary Infarction	1.9%
892	Galactorrhea	1.9%
893	Giant Cell Epulis	1.9%
894	Muscle Weakness	1.9%
895	Subclavian Steal Syndrome	1.9%
896	Musculoskeletal Pain	1.8%
897	Arthralgia	1.8%
898	Polyarthralgia	1.8%
899	Pituitary Apoplexy	1.8%
900	Larva Migrans	1.7%
901	Leishmaniasis	1.7%
902	Molluscum Contagiosum	1.7%
903	Lichen Planus, Oral	1.7%
904	Bunion	1.7%
905	Fibrodysplasia Ossificans Progressiva	1.7%
906	Myoglobinuria	1.7%
907	Myositis Ossificans	1.7%
908	Tenosynovitis	1.7%
909	Sacroiliitis	1.7%
910	Onchocerciasis	1.7%
911	Granulomatosis with polyangiitis	1.7%
912	Myalgia	1.7%
913	Chromoblastomycosis	1.7%
914	Dermatophytosis	1.7%
915	Sporotrichosis	1.7%
916	Tinea	1.7%
917	Tinea Versicolor	1.7%
918	Trichophytosis	1.7%
919	Hyalohyphomycosis	1.7%
920	Acute Generalized Exanthematous Pustulosis	1.7%
921	Cerebral Amyloid Angiopathy	1.7%
922	Warts	1.5%
923	Candidiasis, Chronic Mucocutaneous	1.5%
924	Cutaneous Candidiasis	1.5%
925	Erysipelas	1.5%
926	Serum Sickness	1.5%
927	Staphylococcal Skin Infections	1.5%
928	Erythrasma	1.5%
929	Carcinoma, Lobular	1.5%
930	Arthritis, Infectious	1.5%
931	Leishmaniasis, Cutaneous	1.5%
932	Eczema Herpeticum	1.5%
933	Enthesopathy	1.5%
934	Arthritis, Experimental	1.5%
935	Fusariosis	1.5%
936	Polymyositis	1.5%
937	Epidermodysplasia Verruciformis	1.4%
938	Herpes Labialis	1.4%
939	Hip Dislocation	1.4%
940	Shoulder Dislocation	1.4%
941	Hip Dysplasia	1.4%
942	Staphylococcal Scalded Skin Syndrome	1.4%
943	Orbital Myositis	1.4%
944	Pyomyositis	1.3%
945	Blastomycosis	1.3%
946	HIV-Associated Lipodystrophy Syndrome	1.3%
947	carbuncle	1.3%
948	Hematoma, Subdural	1.3%
949	Hematoma, Epidural, Cranial	1.3%
950	Condylomata Acuminata	1.3%
951	Furunculosis	1.2%
952	furuncle	1.2%
953	Impetigo	1.2%
954	Shoulder Pain	1.2%
955	Rhinoscleroma	1.2%
956	Brain Hemorrhage, Traumatic	1.2%
957	Hematoma, Subdural, Intracranial	1.1%
958	Hematoma, Subdural, Chronic	1.1%
959	Hematoma, Subdural, Acute	1.1%
960	Mitochondrial Encephalomyopathies	1.1%
961	Radicular Cyst	0.7%

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