MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Kwashiorkor

(UMLS:C0022806)

Definition:: A syndrome produced by severe protein deficiency, characterized by retarded growth, changes in skin and hair pigment, edema, and pathologic changes in the liver, including fatty infiltration, necrosis, and fibrosis. The word is a local name in Gold Coast, Africa, meaning "displaced child". Although first reported from Africa, kwashiorkor is now known throughout the world, but mainly in the tropics and subtropics. It is considered to be related to marasmus. (From Dorland, 27th ed)
UMLS ID:: C0022806
MeSH ID:: D007732

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.719.500

Synonym(s)

Kwashiorkor

Deposed child syndrome

Fatty liver of Brahmin children

MALNUTRITION KWASHIORKOR

MALNUTRITION, MALIGNANT

MALNUTRITION, PROTEIN

Malignant malnutrition

NUTRITIONAL EDEMA SYNDROME

Nutritional edema with dyspigmentation of skin AND/OR hair

10.

Nutritional edema with dyspigmentation of skin and hair

Associated Drug(s)

	Name	Data Source
1	Nevirapine	OFFSIDES
2	Stavudine	OFFSIDES
3	Zidovudine	OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Deficiency Diseases	34.4%
2	Starvation	34.4%
3	Refeeding Syndrome	34.4%
4	Child Nutrition Disorders	25.4%
5	Hypervitaminosis A	25.4%
6	Infant Nutrition Disorders	25.4%
7	Wasting Syndrome	23%
8	Magnesium Deficiency	22.6%
9	Potassium Deficiency	22.6%
10	Protein Deficiency	22.6%
11	Avitaminosis	22.6%
12	Ascorbic Acid Deficiency	16.8%
13	Vitamin A Deficiency	16.8%
14	Vitamin D Deficiency	16.8%
15	Vitamin E Deficiency	16.8%
16	Marasmus	16.8%
17	Metabolic Diseases	16.4%
18	Folic Acid Deficiency	13.9%
19	Pellagra	13.9%
20	Thiamine Deficiency	13.9%
21	Vitamin B 12 Deficiency	13.9%
22	Vitamin B 6 Deficiency	13.9%
23	Pyridoxine Deficiency	13.9%
24	Beriberi	12.5%
25	Rickets	9.7%
26	Hyperhomocysteinemia	8.9%
27	Vitamin K Deficiency	8.6%
28	Acid-Base Imbalance	8.5%
29	Calcium Metabolism Disorders	8.5%
30	Iron Metabolism Disorders	8.5%
31	Phosphorus Metabolism Disorders	8.5%
32	Water-Electrolyte Imbalance	8.5%
33	Lipid Metabolism Disorders	8.5%
34	Mitochondrial Diseases	8.5%
35	Glucose Metabolism Disorders	8.5%
36	Anemia, Pernicious	8.3%
37	Osteomalacia	7.6%
38	Scurvy	7.1%
39	Hypercalcemia	6.6%
40	Hypocalcemia	6.6%
41	Milk-Alkali Syndrome	6.6%
42	HIV Wasting Syndrome	6.5%
43	Wernicke Encephalopathy	5.9%
44	Obesity	5.8%
45	Osteopenia	5.7%
46	Brain Diseases, Metabolic	5.6%
47	Lipodystrophy	5%
48	Acidosis	4.9%
49	Alkalosis	4.9%
50	Amyloidosis	4.9%
51	Calcinosis	4.9%
52	Hyperglycemia	4.9%
53	Hyperinsulinism	4.9%
54	Hyperkalemia	4.9%
55	Hypernatremia	4.9%
56	Hypoglycemia	4.9%
57	Hypokalemia	4.9%
58	Hyponatremia	4.9%
59	Xanthomatosis	4.9%
60	Hypophosphatemia	4.9%
61	Metabolic acidosis	4.9%
62	Dyslipidemias	4.9%
63	Iron Overload	4.9%
64	Xanthoma	4.9%
65	Renal Osteodystrophy	4.8%
66	Renal rickets	4.8%
67	Obesity, Abdominal	4.8%
68	Subacute Combined Degeneration	4.4%
69	Pseudohypoparathyroidism	4.4%
70	Familial Hypophosphatemic Rickets	4%
71	Brain Diseases, Metabolic, Inborn	3.9%
72	Pediatric Obesity	3.8%
73	Diabetes Mellitus	3.5%
74	Leigh Disease	3.4%
75	Dehydration	3.4%
76	Lipomatosis	3.4%
77	Water Intoxication	3.4%
78	Werner Syndrome	3.4%
79	Achlorhydria	3.3%
80	Amino Acid Metabolism, Inborn Errors	3.3%
81	Bloom Syndrome	3.3%
82	Carbohydrate Metabolism, Inborn Errors	3.3%
83	Metal Metabolism, Inborn Errors	3.3%
84	Osteoporosis	3.3%
85	Progeria	3.3%
86	Lysosomal Storage Diseases	3.3%
87	Bone Demineralization, Pathologic	3.3%
88	Cytochrome-c Oxidase Deficiency	3.3%
89	Peroxisomal Disorders	3.3%
90	Post-Traumatic Osteoporosis	3.3%
91	Prader-Willi Syndrome	3.3%
92	Celiac Disease	3.3%
93	Sprue, Tropical	3.3%
94	Steatorrhea	3.3%
95	Sprue	3.3%
96	Lactose Intolerance	3.2%
97	Acidosis, Lactic	3.2%
98	Calciphylaxis	3.2%
99	Hemosiderosis	3.2%
100	Hypolipoproteinemias	3.2%
101	Ketosis	3.2%
102	Ketonuria	3.2%
103	Ketoacidosis	3.2%
104	Ketonemia	3.2%
105	Vascular calcification	3.2%
106	Carbamoyl-Phosphate Synthase I Deficiency Disease	3%
107	Hyperlipoproteinemia Type IV	2.9%
108	Hyperlipoproteinemia Type V	2.9%
109	Diabetic Ketoacidosis	2.8%
110	Hyperlipidemia, Familial Combined	2.8%
111	Smith-Lemli-Opitz Syndrome	2.8%
112	Galactosemias	2.8%
113	Urea Cycle Disorders, Inborn	2.8%
114	Tyrosinemias	2.8%
115	Mitochondrial Encephalomyopathies	2.7%
116	Congenital Hyperinsulinism	2.7%
117	Hyperlipoproteinemia Type III	2.6%
118	Mitochondrial Myopathies	2.5%
119	Myelinolysis, Central Pontine	2.5%
120	Glycosuria	2.5%
121	Reye Syndrome	2.5%
122	Hepatic Encephalopathy	2.4%
123	Hyperphosphaturia	2.4%
124	Hypercholesterolemia	2.4%
125	Hyperlipoproteinemias	2.4%
126	Hypertriglyceridemia	2.4%
127	Hypoalphalipoproteinemias	2.4%
128	Homocystinuria	2.2%
129	Acidosis, Respiratory	2.2%
130	Adiposis Dolorosa	2.2%
131	Alkalosis, Respiratory	2.2%
132	Alkaptonuria	2.2%
133	Glycogen Storage Disease	2.2%
134	Hypophosphatasia	2.2%
135	Insulin Resistance	2.2%
136	Osteoporosis, Postmenopausal	2.2%
137	Propionic acidemia	2.2%
138	Dihydropyrimidine Dehydrogenase Deficiency	2.2%
139	Cystinosis	2.2%
140	Renal tubular acidosis	2.1%
141	Glycogen storage disease type II	2.1%
142	Gaucher Disease	2.1%
143	Amyloid Neuropathies, Familial	2%
144	Porphyrias, Hepatic	2%
145	Necrobiosis Lipoidica Diabeticorum	2%
146	Fanconi Anemia	1.9%
147	Nesidioblastosis	1.9%
148	Neuronal Ceroid-Lipofuscinoses	1.9%
149	HIV-Associated Lipodystrophy Syndrome	1.8%
150	Zellweger Syndrome	1.8%
151	MELAS Syndrome	1.8%
152	Menkes Kinky Hair Syndrome	1.8%
153	Adrenoleukodystrophy	1.7%
154	Gestational Diabetes	1.7%
155	Latent Autoimmune Diabetes in Adults	1.7%
156	Tay-Sachs Disease	1.7%
157	Diabetes Mellitus, Experimental	1.7%
158	Niemann-Pick Disease, Type C	1.6%
159	Hepatolenticular Degeneration	1.6%
160	Nephrocalcinosis	1.6%
161	Tetany	1.6%
162	Friedreich Ataxia	1.6%
163	Refsum Disease	1.6%
164	Glycosuria, Renal	1.6%
165	Cerebral Amyloid Angiopathy	1.6%
166	Glycogen Storage Disease Type I	1.6%
167	Glycogen Storage Disease Type V	1.6%
168	Mucopolysaccharidosis III	1.6%
169	Fabry Disease	1.6%
170	Kernicterus	1.4%
171	Cockayne Syndrome	1.4%
172	Familial Periodic Paralysis	1.3%
173	Primary amyloidosis	1.3%
174	Kearns-Sayre syndrome	1.3%
175	Variegate Porphyria	1.3%
176	Acute intermittent porphyria	1.3%
177	Porphyria Cutanea Tarda	1.3%
178	Renal Aminoacidurias	1.3%
179	Fanconi Syndrome	1.3%
180	Pseudohypoaldosteronism	1.3%
181	Liddle Syndrome	1.3%
182	Ataxia Telangiectasia	1.3%
183	Optic Atrophy, Hereditary, Leber	1.2%
184	Sjogren-Larsson Syndrome	1.1%
185	Xeroderma Pigmentosum	1.1%
186	Gout	1.1%
187	Amyotrophic Lateral Sclerosis	1.1%
188	Antley-Bixler Syndrome Phenotype	1.1%
189	Canavan Disease	1.1%
190	Alexander Disease	1.1%
191	Mucopolysaccharidosis II	1.1%
192	Hypokalemic periodic paralysis	1%
193	Frontotemporal dementia	1%
194	Cystinuria	1%
195	CREST Syndrome	0.9%
196	Albinism	0.8%
197	Arthritis, Gouty	0.8%
198	Ichthyosis, X-Linked	0.7%

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