Neuroleptic Malignant Syndrome
(UMLS:C0027849)
- Definition:
- A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
- UMLS ID:
- C0027849
- MeSH ID:
- D009459
Classification 1:
- Nervous System Diseases
- MeSH Tree Number(s):
- C10.228.140.079.737|C10.720.737
Classification 2:
- Chemically-Induced Disorders
- MeSH Tree Number(s):
- C25.723.705.600
Synonym(s)
1.
Neuroleptic Malignant Syndrome
2.
Malignant neuroleptic syndrome
3.
NEUROLEPTIC MALIGNANT SYNDROME
4.
NMS
5.
NMS - Neuroleptic malignant syndrome
6.
Neuroleptic malignant syndrome
7.
malignant neuroleptic
8.
malignant neuroleptic syndrome
9.
malignant; neuroleptic syndrome
10.
neuroleptic malignant
11.
neuroleptic malignant syndrome
Associated Drug(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Aripiprazole | FAERS: 196 Canada Vigilance: 6 | 17272970 17414689 18981078 | CTD OFFSIDES SIDER Canada Vigilance US FAERS |
| 2 | Olanzapine | FAERS: 185 Canada Vigilance: 13 |
10085753
10852098 11074330 11282706 12195138 12369263 12397878 12766935 12865583 12872187 14624202 16095481 16804507 17135384 17932448 18294120 18981078 | CTD OFFSIDES SIDER Canada Vigilance US FAERS |
| 3 | Risperidone | FAERS: 174 Canada Vigilance: 15 | CTD OFFSIDES SIDER Canada Vigilance US FAERS | |
| 4 | Quetiapine Fumarate | FAERS: 167 Canada Vigilance: 7 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 5 | Clozapine | FAERS: 130 Canada Vigilance: 73 | CTD SIDER Canada Vigilance US FAERS | |
| 6 | Haloperidol | FAERS: 99 Canada Vigilance: 1 |
1590507
1891487 1973548 2213055 2562951 2720007 6121542 6130277 6134661 6146918 6238132 6407647 6407706 6662980 6703834 6732389 6824251 6836380 6844982 6864584 7569118 7999444 8107921 8683067 8828352 8956674 8961772 9128030 9637888 10628507 11282706 12152854 12195138 12397878 12872187 12883457 15684854 15830831 16669738 17214072 19820435 19857430 20587766 | CTD OFFSIDES SIDER Canada Vigilance US FAERS |
| 7 | ziprasidone | FAERS: 78 | 16352776 16669738 17366349 | CTD OFFSIDES SIDER US FAERS |
| 8 | Metoclopramide | FAERS: 47 | CTD SIDER US FAERS | |
| 9 | Paliperidone Palmitate | FAERS: 31 | SIDER US FAERS | |
| 10 | Paroxetine | FAERS: 30 Canada Vigilance: 2 | CTD OFFSIDES SIDER Canada Vigilance US FAERS | |
| 11 | Quetiapine Fumarate | FAERS: 26 Canada Vigilance: 1 | 15800166 16682107 18426017 | CTD Canada Vigilance US FAERS |
| 12 | Carbamazepine | FAERS: 16 Canada Vigilance: 1 | 1948228 2904624 9807653 | CTD SIDER Canada Vigilance US FAERS |
| 13 | Paliperidone Palmitate | FAERS: 15 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 14 | Lurasidone Hydrochloride | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 15 | Asenapine | FAERS: 11 | US FAERS | |
| 16 | Mirtazapine | FAERS: 11 | US FAERS | |
| 17 | Pregabalin | FAERS: 11 | US FAERS | |
| 18 | Sertraline | FAERS: 11 | US FAERS | |
| 19 | haloperidol decanoate | FAERS: 11 | 9053957 9734560 | CTD OFFSIDES US FAERS |
| 20 | Duloxetine Hydrochloride | FAERS: 10 | OFFSIDES US FAERS | |
| 21 | Pramipexole | FAERS: 10 | US FAERS | |
| 22 | brexpiprazole | FAERS: 9 | US FAERS | |
| 23 | entacapone | FAERS: 9 | OFFSIDES SIDER US FAERS | |
| 24 | Baclofen | FAERS: 8 | 11277611 | CTD US FAERS |
| 25 | Donepezil | FAERS: 8 | US FAERS | |
| 26 | Venlafaxine Hydrochloride | FAERS: 8 Canada Vigilance: 1 | 10675082 15362259 | CTD Canada Vigilance US FAERS |
| 27 | Zonisamide | FAERS: 8 | SIDER US FAERS | |
| 28 | Lamotrigine | FAERS: 7 | US FAERS | |
| 29 | Levetiracetam | FAERS: 7 | US FAERS | |
| 30 | Valproic Acid | FAERS: 7 | US FAERS | |
| 31 | Valproic Acid | FAERS: 7 | OFFSIDES US FAERS | |
| 32 | carbidopa, levodopa drug combination | FAERS: 7 | 8101521 | CTD US FAERS |
| 33 | rotigotine | FAERS: 7 | US FAERS | |
| 34 | Bromocriptine | FAERS: 6 | US FAERS | |
| 35 | Chlorpromazine | FAERS: 6 | CTD OFFSIDES SIDER US FAERS | |
| 36 | Fluvoxamine | FAERS: 6 | US FAERS | |
| 37 | Promethazine | FAERS: 6 | 1485575 10548178 | CTD SIDER US FAERS |
| 38 | carbidopa, levodopa drug combination | FAERS: 6 | OFFSIDES US FAERS | |
| 39 | Maprotiline | FAERS: 5 | US FAERS | |
| 40 | Rivastigmine | FAERS: 5 | 18294120 | CTD US FAERS |
| 41 | ziprasidone | FAERS: 5 | US FAERS | |
| 42 | Apomorphine | FAERS: 4 | US FAERS | |
| 43 | Cabergoline | FAERS: 4 | OFFSIDES US FAERS | |
| 44 | Cariprazine hydrochloride | FAERS: 4 | US FAERS | |
| 45 | Chlorpromazine | FAERS: 4 | US FAERS | |
| 46 | Duloxetine Hydrochloride | FAERS: 4 | US FAERS | |
| 47 | Haloperidol lactate | FAERS: 4 | US FAERS | |
| 48 | Oseltamivir | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 49 | Sertraline | FAERS: 4 | SIDER US FAERS | |
| 50 | Tetrabenazine | FAERS: 4 | 24881749 | CTD SIDER US FAERS |
| 51 | fluphenazine depot | FAERS: 4 | 762037 6650696 | CTD OFFSIDES US FAERS |
| 52 | fomesafen | FAERS: 4 | US FAERS | |
| 53 | rofecoxib | FAERS: 4 | US FAERS | |
| 54 | Atomoxetine Hydrochloride | FAERS: 3 | US FAERS | |
| 55 | Atorvastatin | FAERS: 3 | US FAERS | |
| 56 | Donepezil | FAERS: 3 | 12654986 14731314 | CTD OFFSIDES SIDER US FAERS |
| 57 | Fluphenazine | FAERS: 3 | US FAERS | |
| 58 | Fluphenazine | FAERS: 3 | CTD OFFSIDES SIDER US FAERS | |
| 59 | Galantamine | FAERS: 3 | US FAERS | |
| 60 | Mesalamine | FAERS: 3 | US FAERS | |
| 61 | Metoclopramide | FAERS: 3 | US FAERS | |
| 62 | Prochlorperazine | FAERS: 3 | SIDER US FAERS | |
| 63 | Promethazine | FAERS: 3 | US FAERS | |
| 64 | Valproic Acid | FAERS: 3 | US FAERS | |
| 65 | fosphenytoin | FAERS: 3 | US FAERS | |
| 66 | iloperidone | FAERS: 3 | US FAERS | |
| 67 | ropinirole | FAERS: 3 | OFFSIDES US FAERS | |
| 68 | Amantadine | FAERS: 2 | 2280828 7118846 10628507 | CTD OFFSIDES SIDER US FAERS |
| 69 | Austedo | FAERS: 2 | US FAERS | |
| 70 | Biperiden | FAERS: 2 | OFFSIDES US FAERS | |
| 71 | Carbidopa, levodopa, and entacapone | FAERS: 2 | US FAERS | |
| 72 | Citalopram | FAERS: 2 | SIDER US FAERS | |
| 73 | Clonazepam | FAERS: 2 | 17214072 | CTD OFFSIDES US FAERS |
| 74 | Desvenlafaxine Succinate | FAERS: 2 | US FAERS | |
| 75 | Diazepam | FAERS: 2 | CTD OFFSIDES US FAERS | |
| 76 | Droxidopa | FAERS: 2 | US FAERS | |
| 77 | Fentanyl | FAERS: 2 | OFFSIDES US FAERS | |
| 78 | Furosemide | FAERS: 2 | US FAERS | |
| 79 | Gabapentin | FAERS: 2 | US FAERS | |
| 80 | Imipramine | FAERS: 2 | OFFSIDES US FAERS | |
| 81 | Imipramine | FAERS: 2 | US FAERS | |
| 82 | Loxapine | FAERS: 2 Canada Vigilance: 1 | 6822486 | CTD OFFSIDES SIDER Canada Vigilance US FAERS |
| 83 | Methadone | FAERS: 2 | US FAERS | |
| 84 | Modafinil | FAERS: 2 | US FAERS | |
| 85 | Naltrexone | FAERS: 2 | US FAERS | |
| 86 | Phenytoin | FAERS: 2 | 17156702 | CTD US FAERS |
| 87 | Pimozide | FAERS: 2 | 7234452 | CTD OFFSIDES SIDER US FAERS |
| 88 | Pramipexole | FAERS: 2 | OFFSIDES US FAERS | |
| 89 | Pramipexole | FAERS: 2 | US FAERS | |
| 90 | Propofol | FAERS: 2 | US FAERS | |
| 91 | Pseudoephedrine | FAERS: 2 | US FAERS | |
| 92 | Riluzole | FAERS: 2 | US FAERS | |
| 93 | Rosuvastatin Calcium | FAERS: 2 | US FAERS | |
| 94 | Tamsulosin | FAERS: 2 | US FAERS | |
| 95 | Tramadol | FAERS: 2 | US FAERS | |
| 96 | Triazolam | FAERS: 2 | OFFSIDES US FAERS | |
| 97 | Vortioxetine | FAERS: 2 | US FAERS | |
| 98 | aripiprazole lauroxil | FAERS: 2 | US FAERS | |
| 99 | cyclobenzaprine | FAERS: 2 | US FAERS | |
| 100 | tofacitinib | FAERS: 2 | US FAERS | |
| 101 | 4-Aminopyridine | FAERS: 1 | US FAERS | |
| 102 | Alprazolam | FAERS: 1 | 16720068 | CTD US FAERS |
| 103 | Amantadine | FAERS: 1 | US FAERS | |
| 104 | Amiodarone | FAERS: 1 | US FAERS | |
| 105 | Amitriptyline | FAERS: 1 | SIDER US FAERS | |
| 106 | Benztropine | FAERS: 1 | US FAERS | |
| 107 | Bupivacaine | FAERS: 1 | US FAERS | |
| 108 | Ciprofloxacin | FAERS: 1 | US FAERS | |
| 109 | Citalopram | FAERS: 1 | US FAERS | |
| 110 | Clomipramine | FAERS: 1 | US FAERS | |
| 111 | Dabigatran | FAERS: 1 | US FAERS | |
| 112 | Daptomycin | FAERS: 1 | US FAERS | |
| 113 | Dexmedetomidine | FAERS: 1 | US FAERS | |
| 114 | Diclofenac | FAERS: 1 | US FAERS | |
| 115 | Droperidol | FAERS: 1 | 11406684 | CTD OFFSIDES SIDER US FAERS |
| 116 | Fluoxetine | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 117 | Fluvoxamine | FAERS: 1 | 15800166 | CTD OFFSIDES SIDER US FAERS |
| 118 | Imipenem | FAERS: 1 | US FAERS | |
| 119 | Linezolid | FAERS: 1 | US FAERS | |
| 120 | Lisdexamfetamine Dimesylate | FAERS: 1 | US FAERS | |
| 121 | Lithium Carbonate | FAERS: 1 | 6130277 | CTD OFFSIDES US FAERS |
| 122 | Lithium | FAERS: 1 Canada Vigilance: 1 | CTD OFFSIDES Canada Vigilance US FAERS | |
| 123 | Lorazepam | FAERS: 1 | CTD OFFSIDES SIDER US FAERS | |
| 124 | MDV 3100 | FAERS: 1 | US FAERS | |
| 125 | Methylphenidate | FAERS: 1 | 9831002 | CTD SIDER US FAERS |
| 126 | Methylphenidate | FAERS: 1 | US FAERS | |
| 127 | Milnacipran | FAERS: 1 | OFFSIDES SIDER US FAERS | |
| 128 | Milnacipran | FAERS: 1 | US FAERS | |
| 129 | Misoprostol | FAERS: 1 | US FAERS | |
| 130 | Molindone | FAERS: 1 | US FAERS | |
| 131 | Olanzapine pamoate | FAERS: 1 | US FAERS | |
| 132 | Omeprazole | FAERS: 1 | US FAERS | |
| 133 | Ondansetron | FAERS: 1 | US FAERS | |
| 134 | Oxcarbazepine | FAERS: 1 | 18774435 | CTD US FAERS |
| 135 | Paroxetine | FAERS: 1 | US FAERS | |
| 136 | Pioglitazone | FAERS: 1 | US FAERS | |
| 137 | Primidone | FAERS: 1 | OFFSIDES US FAERS | |
| 138 | Rocuronium | FAERS: 1 | US FAERS | |
| 139 | Sulpiride | FAERS: 1 | OFFSIDES US FAERS | |
| 140 | Sunitinib | FAERS: 1 | US FAERS | |
| 141 | Thioridazine | FAERS: 1 | CTD SIDER US FAERS | |
| 142 | Thiothixene | FAERS: 1 | 6130277 | CTD OFFSIDES SIDER US FAERS |
| 143 | Topiramate | FAERS: 1 | US FAERS | |
| 144 | Tramadol | FAERS: 1 | US FAERS | |
| 145 | Trazodone | FAERS: 1 | OFFSIDES US FAERS | |
| 146 | Trihexyphenidyl | FAERS: 1 | US FAERS | |
| 147 | Venlafaxine Hydrochloride | FAERS: 1 | SIDER US FAERS | |
| 148 | Vilazodone Hydrochloride | FAERS: 1 | US FAERS | |
| 149 | Voriconazole | FAERS: 1 | US FAERS | |
| 150 | Zoledronic Acid | FAERS: 1 | US FAERS | |
| 151 | dexamethasone 21-phosphate | FAERS: 1 | US FAERS | |
| 152 | empagliflozin | FAERS: 1 | US FAERS | |
| 153 | gemcitabine | FAERS: 1 | US FAERS | |
| 154 | pimavanserin | FAERS: 1 | US FAERS | |
| 155 | suvorexant | FAERS: 1 | US FAERS | |
| 156 | ziconotide | FAERS: 1 | US FAERS | |
| 157 | 5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride | OFFSIDES | ||
| 158 | Acetaminophen | 1590507 | CTD | |
| 159 | Acetic acid;cobalt(2+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2S)-1-[3-[(2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate | OFFSIDES | ||
| 160 | Alosenn | OFFSIDES | ||
| 161 | Amisulpride | 18562406 18774435 | CTD OFFSIDES SIDER | |
| 162 | Amoxapine | 10710250 | CTD OFFSIDES SIDER | |
| 163 | Amphetamine | 8801378 | CTD SIDER | |
| 164 | Ampicillin | OFFSIDES | ||
| 165 | Asenapine | SIDER | ||
| 166 | Atomoxetine Hydrochloride | SIDER | ||
| 167 | Atropine | OFFSIDES | ||
| 168 | Benztropine | 1590507 4707025 16669738 | CTD OFFSIDES | |
| 169 | Bromocriptine | CTD OFFSIDES SIDER | ||
| 170 | Bupropion | 17214072 | CTD | |
| 171 | Butylscopolammonium Bromide | OFFSIDES | ||
| 172 | Carbidopa | SIDER | ||
| 173 | Carvedilol | OFFSIDES | ||
| 174 | Cefaclor | OFFSIDES | ||
| 175 | Cefmetazole | OFFSIDES | ||
| 176 | Cimetidine | OFFSIDES | ||
| 177 | Clodronic Acid | OFFSIDES | ||
| 178 | Clomipramine | OFFSIDES SIDER | ||
| 179 | Clopenthixol | OFFSIDES SIDER | ||
| 180 | Clorazepate Dipotassium | OFFSIDES | ||
| 181 | Cocaine | 7955717 8801378 | CTD | |
| 182 | Codeine | OFFSIDES | ||
| 183 | Dantrolene |
1295627
1587202 2044308 2925603 6123782 6614876 6682201 6824251 7999444 9128030 10675082 12397878 15362259 16669738 17119106 | CTD OFFSIDES | |
| 184 | Desipramine | SIDER | ||
| 185 | Dexmedetomidine | OFFSIDES | ||
| 186 | Didanosine | OFFSIDES | ||
| 187 | Dimethindene | OFFSIDES | ||
| 188 | Dioctyl Sulfosuccinic Acid | OFFSIDES | ||
| 189 | Diphenhydramine | 16669738 | CTD | |
| 190 | Disulfiram | OFFSIDES | ||
| 191 | Docusate sodium | OFFSIDES | ||
| 192 | Domperidone | 1587202 16960712 | CTD | |
| 193 | Doxepin | OFFSIDES | ||
| 194 | Ephedrine | OFFSIDES | ||
| 195 | Estazolam | OFFSIDES | ||
| 196 | Famotidine | OFFSIDES | ||
| 197 | Flavoxate | OFFSIDES | ||
| 198 | Flunitrazepam | OFFSIDES | ||
| 199 | Flupenthixol | 6428599 | CTD OFFSIDES | |
| 200 | Fluvastatin | OFFSIDES | ||
| 201 | Glycyrrhizic Acid | OFFSIDES | ||
| 202 | Hydron;carbonate | OFFSIDES | ||
| 203 | Hydroxyzine | OFFSIDES | ||
| 204 | Levodopa | 1295627 2044308 | CTD OFFSIDES | |
| 205 | Lofepramine | OFFSIDES | ||
| 206 | Loratadine | OFFSIDES | ||
| 207 | Losartan | OFFSIDES | ||
| 208 | Lurasidone Hydrochloride | SIDER | ||
| 209 | Mannitol | OFFSIDES | ||
| 210 | Maprotiline | 12654986 | CTD OFFSIDES | |
| 211 | Melatonin | OFFSIDES | ||
| 212 | Memantine | SIDER | ||
| 213 | Methotrimeprazine | 1891487 12452552 | CTD OFFSIDES | |
| 214 | Mianserin | OFFSIDES SIDER | ||
| 215 | Molindone | 1803792 | CTD | |
| 216 | Nitrazepam | OFFSIDES | ||
| 217 | Nizatidine | OFFSIDES | ||
| 218 | Nomifensine | 7234452 | CTD | |
| 219 | Norfloxacin | OFFSIDES | ||
| 220 | Oxazepam | OFFSIDES | ||
| 221 | Pergolide | OFFSIDES SIDER | ||
| 222 | Perphenazine | 3588517 | CTD OFFSIDES SIDER | |
| 223 | Phenelzine | 8683067 | CTD | |
| 224 | Phenobarbital | 1485575 | CTD | |
| 225 | Potassium Acetate | OFFSIDES | ||
| 226 | Prazosin | OFFSIDES | ||
| 227 | Procyclidine | 6407647 | CTD | |
| 228 | Promazine | OFFSIDES | ||
| 229 | Propranolol | 10628507 | CTD | |
| 230 | Pyrazinamide | OFFSIDES | ||
| 231 | Salmeterol Xinafoate | OFFSIDES | ||
| 232 | Salmeterol Xinafoate | OFFSIDES | ||
| 233 | Selegiline | OFFSIDES | ||
| 234 | Selegiline | SIDER | ||
| 235 | Sodium Bicarbonate | 16669738 | CTD | |
| 236 | Spironolactone | OFFSIDES | ||
| 237 | Thiamine | OFFSIDES | ||
| 238 | Tiagabine | OFFSIDES | ||
| 239 | Tiapamil Hydrochloride | 6238132 | CTD | |
| 240 | Tiapride Hydrochloride | OFFSIDES | ||
| 241 | Tiapride Hydrochloride | 24881749 | CTD | |
| 242 | Ticlopidine | OFFSIDES | ||
| 243 | Tolcapone | OFFSIDES SIDER | ||
| 244 | Tranylcypromine | OFFSIDES | ||
| 245 | Trifluoperazine | 2036482 10197221 10675082 | CTD OFFSIDES SIDER | |
| 246 | Trihexyphenidyl | OFFSIDES SIDER | ||
| 247 | Trimethoprim | OFFSIDES | ||
| 248 | Trimipramine | 2925603 | CTD | |
| 249 | Ursodeoxycholic Acid | OFFSIDES | ||
| 250 | Vitamin A | OFFSIDES | ||
| 251 | Vitamin D | OFFSIDES | ||
| 252 | Vitamin E Nicotinate | OFFSIDES | ||
| 253 | arotinolol | OFFSIDES | ||
| 254 | azosemide | OFFSIDES | ||
| 255 | brotizolam | OFFSIDES | ||
| 256 | cetraxate | OFFSIDES | ||
| 257 | clothiapine | 1674666 | CTD | |
| 258 | cloxazolam | OFFSIDES | ||
| 259 | cyamemazine | OFFSIDES | ||
| 260 | cyclobenzaprine | 7714231 | CTD SIDER | |
| 261 | ethyl loflazepate | OFFSIDES | ||
| 262 | etizolam | OFFSIDES | ||
| 263 | flupenthixol decanoate | 9536144 | CTD | |
| 264 | fluphenazine enanthate | 4707025 | CTD | |
| 265 | geranylgeranylacetone | OFFSIDES | ||
| 266 | ibudilast | OFFSIDES | ||
| 267 | mepronizine | OFFSIDES | ||
| 268 | mizoribine | OFFSIDES | ||
| 269 | mosapride | OFFSIDES | ||
| 270 | nefazodone | SIDER | ||
| 271 | periciazine | OFFSIDES SIDER | ||
| 272 | perospirone | OFFSIDES | ||
| 273 | phenothiazine | 8101521 | CTD | |
| 274 | pipamperone | OFFSIDES | ||
| 275 | pranlukast | OFFSIDES | ||
| 276 | quazepam | OFFSIDES | ||
| 277 | reslin | OFFSIDES | ||
| 278 | rilmazafone | OFFSIDES | ||
| 279 | sennoside A&B | OFFSIDES | ||
| 280 | tandospirone | OFFSIDES | ||
| 281 | tulobuterol | OFFSIDES | ||
| 282 | urapidil | OFFSIDES | ||
| 283 | voglibose | OFFSIDES | ||
| 284 | zaleplon | OFFSIDES | ||
| 285 | zotepine | OFFSIDES |
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