MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Spina Bifida Cystica

(UMLS:C0037917)

Definition:: A form of spinal dysraphism associated with a protruding cyst made up of either meninges (i.e., a MENINGOCELE) or meninges in combination with spinal cord tissue (i.e., a MENINGOMYELOCELE). These lesions are frequently associated with spinal cord dysfunction, HYDROCEPHALUS, and SYRINGOMYELIA. (From Davis et al., Textbook of Neuropathology, 2nd ed, pp224-5)
UMLS ID:: C0037917
MeSH ID:: D016137

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.680.800.730

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.666.680.800.730

Synonym(s)

Spina Bifida Cystica

Spina bifida aperta

Spina bifida cystica

congenital spinal anomaly spina bifida aperta

congenital spinal anomaly spina bifida cystica

spina bifida aperta

spina bifida cystica

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Choline	22473653	CTD
2	Nicotine	22473653	CTD
3	Tretinoin	1440416 2190788 30267739	CTD
4	Valproic Acid	View details 1283633 1377411 1440416 1574165 8558327 22051200	CTD
5	Vitamin A	8422324	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Dermal Sinus	48.8%
2	Spina Bifida Occulta	48.8%
3	Meningomyelocele	35.2%
4	Anencephaly	33.2%
5	Meningocele	28.3%
6	Encephalocele	28.3%
7	Hydranencephaly	27%
8	Septo-Optic Dysplasia	27%
9	Cortical Dysplasia	27%
10	Malformations of Cortical Development	27%
11	Dural Arteriovenous Fistula	20.4%
12	Dandy-Walker Syndrome	20%
13	Central Nervous System Cysts	19.6%
14	Aicardi's syndrome	15.9%
15	Holoprosencephaly	15.1%
16	Abnormalities, Drug-Induced	14.9%
17	Situs Inversus	14.9%
18	Smith-Magenis syndrome	12.5%
19	Eye Abnormalities	11.8%
20	Cardiovascular Abnormalities	11.8%
21	Beckwith-Wiedemann Syndrome	11.5%
22	Wolf-Hirschhorn Syndrome	11.5%
23	Skin Abnormalities	11.4%
24	Lymphatic Abnormalities	11.4%
25	Congenital Microtia	11.4%
26	Charcot-Marie-Tooth Disease	11.3%
27	Congenital diaphragmatic hernia	11.1%
28	Classical Lissencephalies and Subcortical Band Heterotopias	11.1%
29	Cri-du-Chat Syndrome	10.6%
30	Down Syndrome	10.6%
31	Trisomy 21	10.6%
32	Cranial nerve diseases	10.4%
33	Demyelinating Diseases	10.4%
34	Demyelination	10.4%
35	Neuromuscular Diseases	10.4%
36	Chronobiology Disorders	10.4%
37	Lissencephaly	10.4%
38	Polymicrogyria	10.4%
39	Pachygyria	10.4%
40	Schizencephaly	10.4%
41	Periventricular Nodular Heterotopia	10.4%
42	Genetic Diseases, Inborn	9.8%
43	Alstrom Syndrome	9.7%
44	Urogenital Abnormalities	9.5%
45	Microcephaly	9.4%
46	Macrocephaly	9.4%
47	Prader-Willi Syndrome	9.1%
48	Rubinstein-Taybi Syndrome	8.7%
49	Porencephaly	8.5%
50	Motor Neuron Disease	8.4%
51	Mobius Syndrome	8.3%
52	Ectodermal Dysplasia	8.2%
53	Aplasia Cutis Congenita	8.2%
54	Trauma, Nervous System	8.1%
55	Prune Belly Syndrome	8.1%
56	Twins, Conjoined	8.1%
57	Waardenburg Syndrome	8.1%
58	CHARGE Syndrome	8%
59	Tuberous Sclerosis	8%
60	Nervous System Neoplasms	7.9%
61	Neurologic Manifestations	7.9%
62	Neurotoxicity Syndromes	7.9%
63	Fetal Diseases	7.4%
64	Stiff-Person Syndrome	7.3%
65	Refsum Disease	7.2%
66	Multiple System Atrophy	7.2%
67	Ocular Motility Disorders	7%
68	Cyclophoria	7%
69	Nail-Patella Syndrome	6.7%
70	Restless Legs Syndrome	6.7%
71	Polyradiculoneuropathy	6.7%
72	Polyradiculoneuritis	6.7%
73	Xeroderma	6.6%
74	Encephalomyelitis	6.6%
75	Prion Diseases	6.6%
76	Autonomic Dysreflexia	6.6%
77	Complex Regional Pain Syndromes	6.6%
78	Maxillofacial Abnormalities	6.6%
79	Dextrocardia	6.5%
80	Williams Syndrome	6.5%
81	Sleep Wake Disorders	6.4%
82	Cockayne Syndrome	6.4%
83	Abnormalities, Radiation-Induced	6.3%
84	Anophthalmos	6.2%
85	Anus, Imperforate	6.2%
86	Microphthalmos	6.2%
87	Limb Deformities, Congenital	6.2%
88	Craniofacial Abnormalities	6.2%
89	Myasthenic Syndromes, Congenital	6.2%
90	Anorectal Malformations	6.2%
91	Subacute Combined Degeneration	6.2%
92	Bloom Syndrome	6.1%
93	Marfan Syndrome	6.1%
94	Spinal Muscular Atrophy	5.9%
95	Progressive Muscular Atrophy	5.9%
96	Marchiafava-Bignami Disease	5.8%
97	Kartagener Syndrome	5.7%
98	Amyotrophic Lateral Sclerosis	5.6%
99	Ophthalmoplegic Migraine	5.6%
100	Parkinson Disease	5.6%
101	Spinal Cord Injuries	5.5%
102	Brain Diseases	5.5%
103	Dysautonomia	5.5%
104	Meningitis	5.5%
105	Movement Disorders	5.5%
106	Pachymeningitis	5.5%
107	Spinal Cord Diseases	5.5%
108	Vagus Nerve Disorder	5.5%
109	Glossopharyngeal Neuralgia	5.5%
110	Abducens Nerve Diseases	5.5%
111	Heavy Metal Poisoning, Nervous System	5.5%
112	Neuromuscular Junction Diseases	5.5%
113	Tauopathies	5.5%
114	Trochlear Nerve Diseases	5.5%
115	Peripheral Nervous System Diseases	5.5%
116	Meningoencephalitis	5.4%
117	Polycystic Kidney Diseases	5.4%
118	Peripheral Nerve Injuries	5.4%
119	Myasthenia Gravis	5.3%
120	Asterixis	5.3%
121	Ballismus	5.3%
122	Cystic Fibrosis	5.2%
123	Dystonia Musculorum Deformans	5.1%
124	POEMS Syndrome	5.1%
125	Scimitar Syndrome	5.1%
126	Blepharophimosis	5.1%
127	Laryngostenosis	5.1%
128	Mouth Abnormalities	5.1%
129	Esophageal Atresia	5%
130	Intestinal Atresia	5%
131	Horseshoe Kidney	5%
132	Pectus excavatum	5%
133	Abdominal Cramps	5%
134	Amniotic Band Syndrome	5%
135	Asphyxia Neonatorum	5%
136	Infant, Premature, Diseases	5%
137	Infantile Colic	5%
138	Klippel-Feil Syndrome	5%
139	Gastroschisis	5%
140	Synostosis	5%
141	Acrodermatitis	4.9%
142	Lymphangiectasis, Intestinal	4.9%
143	Gianotti-Crosti Syndrome	4.9%
144	Lewy Body Disease	4.9%
145	Pneumocephalus	4.9%
146	Poliomyelitis	4.9%
147	Myelitis	4.9%
148	Progressive bulbar palsy	4.9%
149	Bulbar palsy	4.9%
150	Guillain-Barre Syndrome	4.9%
151	Retinal Dysplasia	4.8%
152	Fragile X Syndrome	4.8%
153	Aniridia	4.8%
154	Epidermolysis Bullosa	4.7%
155	Chronic Fatigue Syndrome	4.6%
156	Neuroleptic Malignant Syndrome	4.6%
157	Myelinolysis, Central Pontine	4.6%
158	Sleep Disorders, Circadian Rhythm	4.6%
159	Striatonigral Degeneration	4.6%
160	Lambert-Eaton Myasthenic Syndrome	4.6%
161	Causalgia	4.5%
162	Ataxia Telangiectasia	4.4%
163	Botulism	4.4%
164	Central Nervous System Infection	4.4%
165	Myopathy	4.4%
166	Optic Neuropathy	4.4%
167	Meconium Aspiration Syndrome	4.4%
168	Epidural Abscess	4.3%
169	Olfactory Nerve Injuries	4.3%
170	Progressive supranuclear palsy	4.3%
171	Muscular Dystrophy	4.3%
172	Congenital nystagmus	4.3%
173	Arthrogryposis	4.2%
174	Choanal Atresia	4.2%
175	Tracheobronchomegaly	4.2%
176	Laryngocele	4.2%
177	Smith-Lemli-Opitz Syndrome	4.2%
178	Myelitis, Transverse	4.2%
179	Facial Nerve Diseases	4.2%
180	Craniocerebral Trauma	4.2%
181	Parasomnia	4.2%
182	Dyssomnias	4.2%
183	MPTP Poisoning	4.2%
184	Choledochal Cyst	4.2%
185	Hermaphroditism	4.2%
186	Disorders of Sex Development	4.2%
187	Craniosynostosis	4.2%
188	Myotonic Dystrophy	4.2%
189	Syndactyly	4.2%
190	Brachycephaly	4.2%
191	Lafora Disease	4.2%
192	Unverricht-Lundborg Syndrome	4.2%
193	Dyskinesia, Drug-Induced	4.2%
194	Cryptorchidism	4.2%
195	Hypospadias	4.2%
196	Vestibulocochlear Nerve Diseases	4.1%
197	Decerebrate State	4.1%
198	Hemiparesis	4.1%
199	Meningism	4.1%
200	Paresis	4.1%
201	Seizures	4.1%
202	Sensation Disorders	4.1%
203	Central Nervous System Neoplasms	4.1%
204	Complex partial seizures	4.1%
205	Monoparesis	4.1%
206	Neurogenic Inflammation	4.1%
207	Gait Disorders, Neurologic	4.1%
208	Neuromuscular Manifestations	4.1%
209	Sweating, Gustatory	4.1%
210	Auriculotemporal Syndrome	4.1%
211	Leukoencephalitis, Acute Hemorrhagic	4.1%
212	Myotonia Congenita	4.1%
213	Primary Ciliary Dyskinesia	4.1%
214	Encephalomyelitis, Acute Disseminated	4.1%
215	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	4.1%
216	Reflex Sympathetic Dystrophy	4%
217	Subdural Effusion	4%
218	Parkinsonian Disorders	4%
219	Nocturnal Myoclonus Syndrome	4%
220	Opsoclonus-Myoclonus Syndrome	4%
221	Ichthyosis, X-Linked	4%
222	Huntington Disease	4%
223	Miller Fisher Syndrome	4%
224	Canavan Disease	3.9%
225	Alexander Disease	3.9%
226	Shy-Drager Syndrome	3.9%
227	Brain Injuries	3.9%
228	Neoplastic Syndromes, Hereditary	3.9%
229	Toxoplasmosis, Congenital	3.9%
230	Brain Neoplasms	3.9%
231	Multiple Sclerosis	3.9%
232	Spinal Cord Neoplasms	3.9%
233	Neuromyelitis Optica	3.9%
234	Horner Syndrome	3.8%
235	Akathisia, Drug-Induced	3.8%
236	Hepatolenticular Degeneration	3.8%
237	Anemia, Neonatal	3.7%
238	Multiple Epiphyseal Dysplasia	3.7%
239	Osteochondrodysplasias	3.7%
240	Pelger-Huet Anomaly	3.7%
241	Persistent Fetal Circulation Syndrome	3.7%
242	Werner Syndrome	3.7%
243	Facial Nerve Injuries	3.7%
244	Noonan Syndrome	3.7%
245	Umbilical hernia	3.7%
246	Pseudoxanthoma Elasticum	3.7%
247	Amelia	3.6%
248	Arachnodactyly	3.6%
249	Ectopia Cordis	3.6%
250	Ectromelia	3.6%
251	Hemimelia	3.6%
252	Phocomelia	3.6%
253	Sirenomelia	3.6%
254	Polydactyly	3.6%
255	Brachydactyly	3.6%
256	Plagiocephaly	3.6%
257	Lower Extremity Deformities, Congenital	3.6%
258	Upper Extremity Deformities, Congenital	3.6%
259	Single umbilical artery	3.6%
260	Laryngomalacia	3.6%
261	Pectus carinatum	3.6%
262	Bladder Exstrophy	3.5%
263	Epispadias	3.5%
264	Leukomalacia, Periventricular	3.5%
265	Multicystic Dysplastic Kidney	3.5%
266	Muscular Dystrophy, Duchenne	3.5%
267	Pupil Disorders	3.5%
268	Neurobehavioral Manifestations	3.5%
269	Leukoencephalopathy, Progressive Multifocal	3.4%
270	Paraneoplastic Encephalomyelitis	3.4%
271	Xeroderma Pigmentosum	3.3%
272	Uveomeningoencephalitic Syndrome	3.3%
273	Vasculitis, Central Nervous System	3.3%
274	Brain Abscess	3.3%
275	Ophthalmoplegia	3.3%
276	External Ophthalmoplegia	3.3%
277	Scrapie	3.3%
278	Sturge-Weber Syndrome	3.3%
279	Vertigo	3.3%
280	Central Cord Syndrome	3.3%
281	Alcohol-Induced Disorders, Nervous System	3.3%
282	Jet Lag Syndrome	3.3%
283	Zellweger Syndrome	3.3%
284	Presenile dementia	3.3%
285	Senile dementia	3.3%
286	Meningitis, Bacterial	3.3%
287	Meningitis, Fungal	3.3%
288	Limbic Encephalitis	3.2%
289	Myasthenia Gravis, Autoimmune, Experimental	3.2%
290	Akinetic Mutism	3.2%
291	Anoxic Encephalopathy	3.2%
292	Arachnoiditis	3.2%
293	Basal Ganglia Diseases	3.2%
294	Brain Damage, Chronic	3.2%
295	Cerebellar Diseases	3.2%
296	Encephalitis	3.2%
297	Encephalomalacia	3.2%
298	Epilepsy	3.2%
299	Hydrocephalus	3.2%
300	Congenital Hydrocephalus	3.2%
301	Hypothalamic Diseases	3.2%
302	Aseptic Meningitis	3.2%
303	Neuritis	3.2%
304	Polyneuritis	3.2%
305	Radiculitis	3.2%
306	Syringomyelia	3.2%
307	Thalamic Diseases	3.2%
308	Intracranial Hypertension	3.2%
309	Polyneuropathy	3.2%
310	Mononeuritis	3.2%
311	Aura	3.2%
312	Leukoencephalopathy	3.2%
313	Essential Tremor	3.2%
314	Neuroaxonal Dystrophies	3.2%
315	Familial Tremor	3.2%
316	Headache Disorders	3.2%
317	Mononeuropathies	3.2%
318	Intracranial Hypotension	3.2%
319	Brachial Plexus Neuropathies	3.2%
320	Radiculopathy	3.2%
321	Mononeuropathy Multiplex	3.2%
322	Nerve Root Compression	3.2%
323	Brain Edema	3.2%
324	Brain Hypoxia	3.2%
325	Aqueductal Stenosis	3.2%
326	Pneumorrhachis	3.2%
327	Writer's Cramp	3.2%
328	Chorea	3.2%
329	Amyloid Neuropathies, Familial	3.2%
330	Acrodynia	3.2%
331	Friedreich Ataxia	3.2%
332	Epilepsy, Post-Traumatic	3.2%
333	Meige Syndrome	3.2%
334	Brachial Plexus Neuritis	3.2%
335	Neuralgic Amyotrophy	3.2%
336	Cerebral Ventriculitis	3.2%
337	Polycystic Kidney, Autosomal Dominant	3.2%
338	Acrocephalosyndactylia	3.2%
339	Dwarfism	3.1%
340	Turner Syndrome	3.1%
341	Jaw Abnormalities	3.1%
342	Sjogren-Larsson Syndrome	3.1%
343	Duane Retraction Syndrome	3.1%
344	Neonatal Abstinence Syndrome	3.1%
345	Kallmann Syndrome	3.1%
346	Neuronal Ceroid-Lipofuscinoses	3%
347	Fetal Growth Retardation	3%
348	Osteogenesis Imperfecta	3%
349	Fetal Hypoxia	3%
350	Fetal Alcohol Spectrum Disorders	3%
351	Basal Cell Nevus Syndrome	3%
352	Aortic coarctation	2.9%
353	Cor Triatriatum	2.9%
354	Coronary Vessel Anomalies	2.9%
355	Dental Enamel Hypoplasia	2.9%
356	Patent ductus arteriosus	2.9%
357	Ebstein Anomaly	2.9%
358	Heart Septal Defects	2.9%
359	Hypodontia	2.9%
360	Macrostomia	2.9%
361	Microstomia	2.9%
362	Syphilis, Congenital	2.9%
363	Tetralogy of Fallot	2.9%
364	Transposition of Great Vessels	2.9%
365	Hypoplastic Left Heart Syndrome	2.9%
366	May-Thurner Syndrome	2.9%
367	Craniofacial Dysostosis	2.9%
368	Wolff-Parkinson-White Syndrome	2.9%
369	Rett Syndrome	2.9%
370	Cleft Palate	2.9%
371	Vocal Cord Paralysis	2.9%
372	Lupus Vasculitis, Central Nervous System	2.9%
373	Voice Disorders	2.8%
374	Voice Disturbance	2.8%
375	Adrenoleukodystrophy	2.8%
376	Tarsal Tunnel Syndrome	2.8%
377	Cauda Equina Syndrome	2.8%
378	Posterior Leukoencephalopathy Syndrome	2.8%
379	Posterior reversible encephalopathy syndrome	2.8%
380	Antley-Bixler Syndrome Phenotype	2.8%
381	Brain Death	2.8%
382	Coma, Post-Head Injury	2.8%
383	Poland Syndrome	2.7%
384	Amblyopia	2.7%
385	Anemia, Sickle Cell	2.7%
386	Thalassemia	2.7%
387	Paraneoplastic Cerebellar Degeneration	2.7%
388	Familial Mediterranean Fever	2.7%
389	Cerebrospinal Fluid Otorrhea	2.7%
390	Cerebrospinal Fluid Rhinorrhea	2.7%
391	Neuritis, Autoimmune, Experimental	2.7%
392	Gait Ataxia	2.7%
393	Cerebellar Neoplasms	2.7%
394	Creutzfeldt-Jakob disease	2.6%
395	Basal Ganglia Cerebrovascular Disease	2.6%
396	Dementia, Vascular	2.6%
397	Brain Hemorrhage, Traumatic	2.6%
398	Welander Distal Myopathy	2.6%
399	Brain Injuries, Diffuse	2.6%
400	Traumatic Brain Injury	2.6%
401	Cerebellar Ataxia	2.6%
402	Supratentorial Neoplasms	2.6%
403	Torticollis	2.6%
404	Multiple Sclerosis, Chronic Progressive	2.6%
405	Multiple Sclerosis, Relapsing-Remitting	2.6%
406	Autoimmune Lymphoproliferative Syndrome	2.5%
407	Klinefelter Syndrome	2.5%
408	Congenital Hyperinsulinism	2.5%
409	Brain Diseases, Metabolic	2.5%
410	Cerebrovascular Disorders	2.5%
411	Myositis	2.5%
412	Optic Atrophy	2.5%
413	Optic Neuritis	2.5%
414	Papilledema	2.5%
415	Strabismus	2.5%
416	Tolosa-Hunt Syndrome	2.5%
417	Cerebrovascular Insufficiency	2.5%
418	Isaacs syndrome	2.5%
419	Arsenic Poisoning	2.5%
420	Dementia	2.5%
421	Myotonic Disorders	2.5%
422	Central Nervous System Fungal Infections	2.5%
423	Conus Medullaris Syndrome	2.5%
424	Spinal Cord Vascular Diseases	2.5%
425	Chorioamnionitis	2.5%
426	Familial Periodic Paralysis	2.5%
427	Angioedemas, Hereditary	2.5%
428	Long QT Syndrome	2.5%
429	Platybasia	2.5%
430	Tricuspid Atresia	2.5%
431	Arrhythmogenic Right Ventricular Dysplasia	2.5%
432	Brain Diseases, Metabolic, Inborn	2.5%
433	Diabetic Neuropathies	2.4%
434	Facial Injuries	2.4%
435	Facial Neuralgia	2.4%
436	Diabetic Amyotrophy	2.4%
437	Diabetic Autonomic Neuropathy	2.4%
438	Sleep Talking	2.4%
439	Manganese Poisoning	2.4%
440	Sleep Disorders, Intrinsic	2.4%
441	Orthostatic intolerance	2.4%
442	Gonadal Dysgenesis	2.4%
443	Bronchomalacia	2.4%
444	Adrenogenital Syndrome	2.4%
445	Alcohol Withdrawal Seizures	2.4%
446	Tracheomalacia	2.4%
447	Ovotesticular Disorders of Sex Development	2.4%
448	Anosmia	2.4%
449	Ataxia	2.4%
450	Athetosis	2.4%
451	Catalepsy	2.4%
452	Dystonia	2.4%
453	Hemiplegia	2.4%
454	Locked-In Syndrome	2.4%
455	Meningeal Neoplasms	2.4%
456	Muscle Hypertonia	2.4%
457	Muscle hypotonia	2.4%
458	Myoclonus	2.4%
459	Myotonia	2.4%
460	Neuralgia	2.4%
461	Paraplegia	2.4%
462	Pseudobulbar Palsy	2.4%
463	Quadriplegia	2.4%
464	Spasm	2.4%
465	Spastic Paraplegia	2.4%
466	Status Epilepticus	2.4%
467	Taste Disorders	2.4%
468	Tremor	2.4%
469	Monoplegia	2.4%
470	Hypokinesia	2.4%
471	Paraparesis	2.4%
472	Bradykinesia	2.4%
473	Waxy flexibility	2.4%
474	Action Tremor	2.4%
475	Resting Tremor	2.4%
476	Dysosmia	2.4%
477	Quadriparesis	2.4%
478	Mercury Poisoning, Nervous System	2.4%
479	Olfaction Disorders	2.4%
480	Myokymia	2.4%
481	Lead Poisoning, Nervous System	2.4%
482	Vestibular Neuronitis	2.4%
483	Somatosensory Disorders	2.4%
484	Neuropathic pain	2.4%
485	Hyperkinesia	2.4%
486	Intention tremor	2.4%
487	Carotid Artery Injuries	2.4%
488	Menkes Kinky Hair Syndrome	2.4%
489	Hyperkeratosis, Epidermolytic	2.4%
490	Myoclonic Epilepsy	2.4%
491	Epilepsy, Temporal Lobe	2.4%
492	Epilepsy, Rolandic	2.4%
493	Benign Rolandic Epilepsy	2.4%
494	Albinism	2.4%
495	Reflex, Abnormal	2.3%
496	Hyporeflexia	2.3%
497	Hyperreflexia	2.3%
498	Optic Atrophy, Hereditary, Leber	2.3%
499	Akathisia	2.3%
500	Restlessness	2.3%
501	Psychomotor Agitation	2.3%
502	Tuberculosis, Meningeal	2.3%
503	Carpal Tunnel Syndrome	2.3%
504	Vascular Headaches	2.3%
505	neurofibroma	2.2%
506	Hypoxia-Ischemia, Brain	2.2%
507	Sciatica	2.2%
508	Tardive Dyskinesia	2.2%
509	Persistent Vegetative State	2.2%
510	Cerebral Palsy	2.1%
511	Epilepsies, Partial	2.1%
512	Epilepsy, Generalized	2.1%
513	Pseudotumor Cerebri	2.1%
514	Sciatic Neuropathy	2.1%
515	Hypertensive Encephalopathy	2.1%
516	Ulnar Neuropathies	2.1%
517	Lesion of Sciatic Nerve	2.1%
518	Simple Partial Seizures	2.1%
519	Epilepsy, Reflex	2.1%
520	Ulnar Neuritis	2.1%
521	Radial nerve compression	2.1%
522	Radial Tunnel Syndrome	2.1%
523	Peroneal Neuropathies	2.1%
524	Radial Neuropathy	2.1%
525	Median Neuropathy	2.1%
526	Sciatic Nerve Palsy	2.1%
527	Femoral Neuropathy	2.1%
528	Tibial Neuropathy	2.1%
529	Ulnar Nerve Palsy	2.1%
530	Postural Orthostatic Tachycardia Syndrome	2.1%
531	Radial nerve palsy	2.1%
532	Headache Disorders, Primary	2.1%
533	Headache Disorders, Secondary	2.1%
534	Medication overuse headache	2.1%
535	Micrognathism	2.1%
536	Pierre Robin Syndrome	2.1%
537	Alice in Wonderland Syndrome	2.1%
538	Vertebral Artery Dissection	2.1%
539	Mucopolysaccharidosis II	2.1%
540	Amnesia, Transient Global	2.1%
541	Hand-Arm Vibration Syndrome	2.1%
542	Paralysis, Obstetric	2.1%
543	Retinopathy of Prematurity	2.1%
544	Gait Apraxia	2.1%
545	Amino Acid Metabolism, Inborn Errors	2%
546	Carbohydrate Metabolism, Inborn Errors	2%
547	Metal Metabolism, Inborn Errors	2%
548	Progeria	2%
549	Wiskott-Aldrich Syndrome	2%
550	Lysosomal Storage Diseases	2%
551	Cytochrome-c Oxidase Deficiency	2%
552	Peroxisomal Disorders	2%
553	Vision Disorders	2%
554	Metamorphopsia	2%
555	Visual Impairment	2%
556	Bronchopulmonary Dysplasia	2%
557	Fibromyalgia	2%
558	Optic Neuropathy, Ischemic	2%
559	Anterior Ischemic Optic Neuropathy	2%
560	Central Nervous System Bacterial Infections	2%
561	Medial Tibial Stress Syndrome	2%
562	Brain Concussion	2%
563	Optic Nerve Glioma	2%
564	Facial Hemiatrophy	2%
565	Melkersson-Rosenthal Syndrome	2%
566	Mitochondrial Myopathies	2%
567	Juvenile Myoclonic Epilepsy	2%
568	Myoclonic Epilepsies, Progressive	2%
569	Anisocoria	2%
570	Confusion	2%
571	Facial paralysis	2%
572	Lethargy	2%
573	Memory Disorders	2%
574	Muscle Cramp	2%
575	Perceptual Disorders	2%
576	Psychomotor Disorders	2%
577	Tonic Pupil	2%
578	Eosinophilia-Myalgia Syndrome	2%
579	Anhedonia	2%
580	Disorientation	2%
581	Facial Paresis	2%
582	Memory Loss	2%
583	Hemisensory Neglect	2%
584	Dysacusis	2%
585	Toxoplasmosis, Cerebral	2%
586	Sleep Bruxism	2%
587	Muscular Atrophy	2%
588	Respiratory Paralysis	2%
589	Tetany	1.9%
590	Aortopulmonary Septal Defect	1.9%
591	Double Outlet Right Ventricle	1.9%
592	Endocardial Cushion Defects	1.9%
593	Myocardial bridging	1.9%
594	Aorticopulmonary Septal Defect	1.9%
595	Hyperandrogenism	1.9%
596	Cubital Tunnel Syndrome	1.9%
597	Diffuse Axonal Injury	1.9%
598	Brain Stem Neoplasms	1.9%
599	Retrognathia	1.9%
600	Meningitis, Cryptococcal	1.9%
601	Meningitis, Listeria	1.9%
602	Meningitis, Haemophilus	1.9%
603	Meningitis, Pneumococcal	1.9%
604	Frontotemporal dementia	1.9%
605	Kernicterus	1.9%
606	Mitochondrial Encephalomyopathies	1.9%
607	Ophthalmia Neonatorum	1.8%
608	Galactosemias	1.8%
609	Urea Cycle Disorders, Inborn	1.8%
610	Tyrosinemias	1.8%
611	Pituitary Adenoma	1.8%
612	Pituitary Neoplasms	1.8%
613	Acoustic Neuroma	1.8%
614	MELAS Syndrome	1.7%
615	Prognathism	1.7%
616	Pituitary Diseases	1.7%
617	Basal Ganglia Hemorrhage	1.7%
618	Respiratory Distress Syndrome, Newborn	1.7%
619	Fabry Disease	1.7%
620	Consciousness Disorders	1.7%
621	Mental Retardation	1.7%
622	Muscle Weakness	1.7%
623	Depressed Level of Consciousness	1.7%
624	Mental deficiency	1.7%
625	Intellectual Disability	1.7%
626	Bell Palsy	1.7%
627	Cutis Laxa	1.7%
628	Catatonia	1.7%
629	Retinitis Pigmentosa	1.7%
630	Pigmentary retinopathy	1.7%
631	Herpes Zoster Oticus	1.6%
632	Thoracic Outlet Syndrome	1.6%
633	Porokeratosis	1.6%
634	Keratoderma, Palmoplantar	1.6%
635	Aphonia	1.6%
636	Sleep Deprivation	1.6%
637	Dysphonia	1.6%
638	Chronic granulomatous disease	1.6%
639	Pituitary Apoplexy	1.6%
640	Auditory Perceptual Disorders	1.6%
641	Carotid Artery Diseases	1.6%
642	Brain Ischemia	1.6%
643	Esotropia	1.6%
644	Exotropia	1.6%
645	Hypotension, Orthostatic	1.6%
646	Sleep Apnea Syndromes	1.6%
647	Cerebrovascular accident	1.6%
648	Polymyositis	1.6%
649	Kluver-Bucy Syndrome	1.6%
650	Vasospasm, Intracranial	1.6%
651	Spinal Cord Ischemia	1.6%
652	Intracranial Arterial Diseases	1.6%
653	Post-Exercise Hypotension	1.6%
654	Giant Cell Arteritis	1.6%
655	Temporal Arteritis	1.6%
656	Hypokalemic periodic paralysis	1.6%
657	Mandibulofacial Dysostosis	1.6%
658	Disorders of Excessive Somnolence	1.6%
659	Sleep Initiation and Maintenance Disorders	1.6%
660	Night Terrors	1.6%
661	Somnambulism	1.6%
662	Trigeminal Nerve Disorder	1.6%
663	Transient Insomnia	1.6%
664	Sleep Paralysis	1.6%
665	Chronic Insomnia	1.6%
666	REM Sleep Behavior Disorder	1.6%
667	Hypersomnia	1.6%
668	Romano-Ward Syndrome	1.6%
669	Brain Contusion	1.6%
670	Sickle Cell Trait	1.6%
671	Dysgeusia	1.6%
672	Formication	1.6%
673	Hyperalgesia	1.6%
674	Hyperesthesia	1.6%
675	Hypesthesia	1.6%
676	Language Disorders	1.6%
677	Numbness	1.6%
678	Paresthesia	1.6%
679	Paraparesis, Spastic	1.6%
680	Trismus	1.6%
681	Epilepsia Partialis Continua	1.6%
682	Hypogeusia	1.6%
683	Meningeal Carcinomatosis	1.6%
684	Brown-Sequard Syndrome	1.6%
685	Lockjaw	1.6%
686	Allodynia	1.6%
687	Lead Poisoning, Nervous System, Childhood	1.6%
688	Lead Poisoning, Nervous System, Adult	1.6%
689	Brain Infarction	1.6%
690	Ageusia	1.6%
691	Tuberculosis, Central Nervous System	1.6%
692	Polyradiculopathy	1.6%
693	Post-Traumatic Headache	1.6%
694	Tension Headache	1.6%
695	Epilepsy, Complex Partial	1.6%
696	Migraine Disorders	1.6%
697	Abdominal Migraine	1.6%
698	Status Migrainosus	1.6%
699	Cervicogenic Headache	1.6%
700	Subarachnoid Hemorrhage, Traumatic	1.6%
701	Carotid Artery, Internal, Dissection	1.6%
702	Choroid Plexus Papilloma	1.6%
703	Subacute Sclerosing Panencephalitis	1.5%
704	Homocystinuria	1.4%
705	Putaminal Hemorrhage	1.4%
706	Truncus Arteriosus, Persistent	1.4%
707	Leigh Disease	1.4%
708	Goldenhar Syndrome	1.4%
709	Myalgia	1.4%
710	Porphyrias, Hepatic	1.4%
711	Infarction, Middle Cerebral Artery	1.4%
712	Infarction, Anterior Cerebral Artery	1.4%
713	Infarction, Posterior Cerebral Artery	1.4%
714	Alexia	1.4%
715	Dyslexia	1.4%
716	Peutz-Jeghers Syndrome	1.4%
717	Thrombasthenia	1.4%
718	Antithrombin III Deficiency	1.4%
719	Protein C Deficiency	1.4%
720	Afibrinogenemia	1.4%
721	Factor VII Deficiency	1.4%
722	Factor X Deficiency	1.4%
723	Factor XII Deficiency	1.4%
724	Hemophilia A	1.4%
725	Activated Protein C Resistance	1.4%
726	Factor II deficiency	1.4%
727	Factor VIII Deficiency	1.4%
728	Factor V deficiency	1.4%
729	Factor XI Deficiency	1.4%
730	Hypoprothrombinemias	1.4%
731	Glycogen storage disease type II	1.4%
732	Fanconi Anemia	1.3%
733	Nesidioblastosis	1.3%
734	Eye Injuries	1.3%
735	Anemia, Diamond-Blackfan	1.3%
736	Cluster Headache	1.3%
737	Migraine with Aura	1.3%
738	Familial Hemiplegic Migraine	1.3%
739	Chronic Paroxysmal Hemicrania	1.3%
740	SUNCT Syndrome	1.3%
741	Paroxysmal Hemicrania	1.3%
742	Cerebral Infarction	1.3%
743	Brain Stem Infarctions	1.3%
744	Orbital Myositis	1.3%
745	Diplopia	1.3%
746	Muscle Rigidity	1.3%
747	Muscle Spasticity	1.3%
748	Scotoma	1.3%
749	Photophobia	1.3%
750	Cogwheel Rigidity	1.3%
751	Hemifacial Spasm	1.3%
752	Amaurosis	1.3%
753	Blindness	1.3%
754	Nuchal Rigidity	1.3%
755	Reye Syndrome	1.3%
756	Neuroaspergillosis	1.3%
757	Pyomyositis	1.3%
758	Hematoma, Subdural	1.3%
759	Hematoma, Epidural, Cranial	1.3%
760	Intracranial Embolism and Thrombosis	1.3%
761	Hepatic Encephalopathy	1.3%
762	Agnosia	1.3%
763	Apraxias	1.3%
764	Hallucinations	1.3%
765	Hemianopsia	1.3%
766	Hyperacusis	1.3%
767	Tinnitus	1.3%
768	Visual Agnosia	1.3%
769	Anosognosia	1.3%
770	Wernicke-Korsakoff Syndrome	1.3%
771	Phonophobia	1.3%
772	Hearing Loss	1.3%
773	Sarcopenia	1.3%
774	Hydrops Fetalis	1.3%
775	Moyamoya Disease	1.3%
776	Neurofibrosarcoma	1.2%
777	Hoarseness	1.2%
778	Acute Chest Syndrome	1.2%
779	Empty Sella Syndrome	1.2%
780	Hyperpituitarism	1.2%
781	Hypopituitarism	1.2%
782	Hypophysitis	1.2%
783	Alcohol Withdrawal Delirium	1.2%
784	Arteriovenous fistula	1.2%
785	Talipes	1.2%
786	Multiple Endocrine Neoplasia	1.2%
787	Alkaptonuria	1.2%
788	Glycogen Storage Disease	1.2%
789	Hypophosphatasia	1.2%
790	Propionic acidemia	1.2%
791	Dihydropyrimidine Dehydrogenase Deficiency	1.2%
792	Cystinosis	1.2%
793	Kearns-Sayre syndrome	1.2%
794	Cerebral Arterial Diseases	1.2%
795	Vertebrobasilar Insufficiency	1.2%
796	Anterior Spinal Artery Syndrome	1.2%
797	Basilar Artery Stenosis	1.2%
798	Vertebral Artery Stenosis	1.2%
799	Sleep Apnea, Obstructive	1.2%
800	Sleep Apnea, Central	1.2%
801	Intracranial Hemorrhage, Hypertensive	1.2%
802	Transient Cerebral Ischemia	1.2%
803	Narcolepsy	1.2%
804	Trigeminal Neuralgia	1.2%
805	Kleine-Levin Syndrome	1.2%
806	Agraphia	1.2%
807	Anomia	1.2%
808	Cluttering	1.2%
809	Language Development Disorders	1.2%
810	Speech Disorders	1.2%
811	Syncope	1.2%
812	Stupor	1.2%
813	Dysgraphia	1.2%
814	Presyncope	1.2%
815	Dyslalia	1.2%
816	Lateral Medullary Syndrome	1.2%
817	Congenital Hypothyroidism	1.2%
818	Dermatitis, Atopic	1.2%
819	West Nile Fever	1.2%
820	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.2%
821	Pseudorabies	1.1%
822	Amnesia	1.1%
823	Delirium	1.1%
824	Dissociative Amnesia	1.1%
825	Color blindness	1.1%
826	Global Amnesia	1.1%
827	Meningioma	1.1%
828	Neurosyphilis	1.1%
829	Hyperphosphaturia	1.1%
830	Hematoma, Subdural, Intracranial	1%
831	Hematoma, Subdural, Chronic	1%
832	Hematoma, Subdural, Acute	1%
833	Behcet Syndrome	1%
834	Denys-Drash Syndrome	1%
835	Hyperprolactinemia	1%
836	Congenital clubfoot	1%
837	Vertical Talus	1%
838	Subclavian Steal Syndrome	1%
839	Pick Disease of the Brain	1%
840	Cataplexy	1%
841	Aphasia	1%
842	Articulation Disorders	1%
843	Echolalia	1%
844	Stuttering	1%
845	Dysphasia	1%
846	Eye Burns	1%
847	Hyaline Membrane Disease	1%
848	Malaria, Cerebral	1%
849	Gaucher Disease	1%
850	Carotid Stenosis	1%
851	Intracranial Aneurysm	1%
852	Hypolipoproteinemias	1%
853	Papillon-Lefevre Disease	1%
854	Neurocysticercosis	1%
855	Amaurosis Fugax	1%
856	Blindness, Cortical	1%
857	Dyscalculia	1%
858	Intracranial Arteriosclerosis	1%
859	Cerebral Atherosclerosis	1%
860	Hyperlipidemia, Familial Combined	1%
861	Subarachnoid Hemorrhage	1%
862	Cerebral Arteriosclerosis	1%
863	Cerebral Hemorrhage	1%
864	Hyperlipoproteinemia Type III	1%
865	Cerebral Thrombosis	1%
866	Intracranial Embolism	1%
867	Intracranial Thrombosis	1%
868	Deafness	1%
869	Hearing Loss, Sudden	1%
870	Gerstmann Syndrome	1%
871	Hearing Loss, Bilateral	1%
872	Hearing Loss, High-Frequency	1%
873	Hearing Loss, Mixed Conductive-Sensorineural	1%
874	Prosopagnosia	1%
875	Apraxia, Ideomotor	1%
876	Charles Bonnet Syndrome	1%
877	Hearing Loss, Unilateral	1%
878	Complete Hearing Loss	1%
879	Alien Hand Syndrome	1%
880	Deaf Mutism	1%
881	Wernicke Encephalopathy	0.9%
882	AIDS Dementia Complex	0.9%
883	Phantom pain	0.9%
884	Phantom Limb Pain	0.9%
885	Lyme Neuroborreliosis	0.9%
886	Mucopolysaccharidosis III	0.9%
887	Dysarthria	0.9%
888	Dermatomyositis	0.8%
889	Corneal Scar	0.8%
890	Nephroblastoma	0.8%
891	Mutism	0.8%
892	Selective Mutism	0.8%
893	Acromegaly	0.8%
894	Lactose Intolerance	0.8%
895	Variegate Porphyria	0.8%
896	Acute intermittent porphyria	0.8%
897	Porphyria Cutanea Tarda	0.8%
898	Hyperhomocysteinemia	0.8%
899	Waterhouse-Friderichsen Syndrome	0.8%
900	Retrograde amnesia	0.8%
901	Amnesia, Anterograde	0.8%
902	Renal Aminoacidurias	0.8%
903	Fanconi Syndrome	0.8%
904	Pseudohypoaldosteronism	0.8%
905	Liddle Syndrome	0.8%
906	Carotid Artery Thrombosis	0.8%
907	Hyperlipoproteinemia Type IV	0.8%
908	Hyperlipoproteinemia Type V	0.8%
909	Cerebral Amyloid Angiopathy	0.8%
910	Glycogen Storage Disease Type I	0.8%
911	Glycogen Storage Disease Type V	0.8%
912	Sinus Thrombosis, Intracranial	0.8%
913	Tay-Sachs Disease	0.8%
914	Niemann-Pick Disease, Type C	0.8%
915	Adenomatous Polyposis Coli	0.7%
916	Alexia, Pure	0.7%
917	Cavernous Sinus Thrombosis	0.7%
918	Sagittal Sinus Thrombosis	0.7%
919	Gout	0.7%
920	Multiple Endocrine Neoplasia Type 1	0.7%
921	Pseudohypoparathyroidism	0.7%
922	Renal tubular acidosis	0.7%
923	Corneal Perforation	0.7%
924	Hypoalphalipoproteinemias	0.6%
925	Nelson Syndrome	0.6%
926	Prolactinoma	0.6%
927	Growth Hormone-Secreting Pituitary Adenoma	0.6%
928	Glycosuria, Renal	0.5%
929	Cystinuria	0.5%
930	Arthritis, Gouty	0.5%
931	Familial Hypophosphatemic Rickets	0.5%

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