MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Paraneoplastic Cerebellar Degeneration

(UMLS:C0393534)

Definition:: Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
UMLS ID:: C0393534
MeSH ID:: D020362

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.588.614.550.650|C04.730.856.650

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.252.620|C10.574.781.700

Synonym(s)

Paraneoplastic Cerebellar Degeneration

Cerebellar ataxia due to neoplasia

Paraneoplastic cerebellar degeneration

paraneoplastic cerebellar degeneration

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	temsirolimus	FAERS: 3		OFFSIDES US FAERS
2	Gefitinib	FAERS: 1		OFFSIDES US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Limbic Encephalitis	44%
2	Lambert-Eaton Myasthenic Syndrome	37.5%
3	Opsoclonus-Myoclonus Syndrome	36.1%
4	Myelitis, Transverse	34.7%
5	Dandy-Walker Syndrome	25.2%
6	Multiple System Atrophy	24.9%
7	Cerebellar Neoplasms	24.6%
8	Brain Neoplasms	23%
9	Lewy Body Disease	22.7%
10	Meningoencephalitis	21.3%
11	Parkinson Disease	21.2%
12	Central Nervous System Neoplasms	20%
13	Prion Diseases	20%
14	Motor Neuron Disease	19.1%
15	Encephalomyelitis	18.9%
16	Subdural Effusion	18.6%
17	Amyotrophic Lateral Sclerosis	18.3%
18	Dementia, Vascular	18.2%
19	Pneumocephalus	17.7%
20	Cerebellar Ataxia	17.6%
21	Subacute Combined Degeneration	17.4%
22	Spinal Cord Neoplasms	17.4%
23	Pituitary Adenoma	17.3%
24	Pituitary Neoplasms	17.3%
25	Striatonigral Degeneration	17.1%
26	Dystonia Musculorum Deformans	16.8%
27	Huntington Disease	16.7%
28	Tuberous Sclerosis	16.6%
29	Spinal Muscular Atrophy	16.5%
30	Progressive Muscular Atrophy	16.5%
31	Akinetic Mutism	16.4%
32	Anoxic Encephalopathy	16.4%
33	Basal Ganglia Diseases	16.4%
34	Brain Damage, Chronic	16.4%
35	Encephalitis	16.4%
36	Encephalomalacia	16.4%
37	Epilepsy	16.4%
38	Hydrocephalus	16.4%
39	Congenital Hydrocephalus	16.4%
40	Hypothalamic Diseases	16.4%
41	Thalamic Diseases	16.4%
42	Intracranial Hypertension	16.4%
43	Aura	16.4%
44	Leukoencephalopathy	16.4%
45	Neuroaxonal Dystrophies	16.4%
46	Headache Disorders	16.4%
47	Intracranial Hypotension	16.4%
48	Brain Edema	16.4%
49	Brain Hypoxia	16.4%
50	Aqueductal Stenosis	16.4%
51	Parkinsonian Disorders	16.4%
52	Progressive supranuclear palsy	16.3%
53	Friedreich Ataxia	16.3%
54	Posterior Leukoencephalopathy Syndrome	16.3%
55	Posterior reversible encephalopathy syndrome	16.3%
56	Supratentorial Neoplasms	16.2%
57	Miller Fisher Syndrome	15.9%
58	Basal Ganglia Cerebrovascular Disease	15.9%
59	Epilepsy, Post-Traumatic	15.9%
60	Ocular Motility Disorders	15.8%
61	Cyclophoria	15.8%
62	Brain Abscess	15.8%
63	Marchiafava-Bignami Disease	15.5%
64	Tauopathies	15.3%
65	Shy-Drager Syndrome	15.2%
66	Brain Injuries	15.1%
67	Presenile dementia	15%
68	Senile dementia	15%
69	Stiff-Person Syndrome	14.7%
70	Central Nervous System Cysts	14.5%
71	Nervous System Neoplasms	14.4%
72	Epidural Abscess	14.3%
73	Myelitis	14.3%
74	Lafora Disease	14.2%
75	Unverricht-Lundborg Syndrome	14.2%
76	Meige Syndrome	14.1%
77	Cerebral Ventriculitis	14.1%
78	Myoclonic Epilepsy	14.1%
79	Epilepsy, Temporal Lobe	14.1%
80	Epilepsy, Rolandic	14.1%
81	Benign Rolandic Epilepsy	14.1%
82	Abdominal Neoplasms	14%
83	Head and Neck Neoplasms	14%
84	Meningitis	14%
85	Movement Disorders	14%
86	Pachymeningitis	14%
87	Soft Tissue Neoplasms	14%
88	Spinal Cord Diseases	14%
89	Thoracic Neoplasms	14%
90	Vascular Headaches	14%
91	Leukomalacia, Periventricular	13.9%
92	Hypoxia-Ischemia, Brain	13.9%
93	Brain Diseases, Metabolic	13.9%
94	Cerebrovascular Disorders	13.9%
95	Cerebrovascular Insufficiency	13.9%
96	Dementia	13.9%
97	Acoustic Neuroma	13.7%
98	Leukoencephalopathy, Progressive Multifocal	13.5%
99	Brain Death	13.3%
100	Neuroleptic Malignant Syndrome	13.3%
101	Myelinolysis, Central Pontine	13.3%
102	Multiple Endocrine Neoplasia	13.2%
103	Meningeal Neoplasms	13.1%
104	Meningioma	13.1%
105	Cranial nerve diseases	13%
106	Demyelinating Diseases	13%
107	Demyelination	13%
108	Hamartoma	13%
109	Neoplasms, Hormone-Dependent	13%
110	Neoplasms, Multiple Primary	13%
111	Neuromuscular Diseases	13%
112	Precancerous Conditions	13%
113	Neoplasms, Second Primary	13%
114	Chronobiology Disorders	13%
115	Leukoencephalitis, Acute Hemorrhagic	13%
116	Brain Stem Neoplasms	12.9%
117	Ophthalmoplegic Migraine	12.9%
118	Hepatolenticular Degeneration	12.7%
119	Lupus Vasculitis, Central Nervous System	12.6%
120	Canavan Disease	12.4%
121	Alexander Disease	12.4%
122	Optic Nerve Glioma	12.4%
123	Amblyopia	12.4%
124	Creutzfeldt-Jakob disease	12.1%
125	Progressive bulbar palsy	12.1%
126	Bulbar palsy	12.1%
127	Central Nervous System Infection	12.1%
128	Digestive System Neoplasms	12.1%
129	Endocrine Gland Neoplasms	12.1%
130	Eye Neoplasms	12.1%
131	Poliomyelitis	11.9%
132	MPTP Poisoning	11.9%
133	Basal Ganglia Hemorrhage	11.9%
134	Juvenile Myoclonic Epilepsy	11.9%
135	Myoclonic Epilepsies, Progressive	11.9%
136	Bone neoplasms	11.8%
137	Skin Neoplasms	11.8%
138	Hematologic Neoplasms	11.8%
139	Spinal Cord Injuries	11.8%
140	Splenic Neoplasms	11.7%
141	Restless Legs Syndrome	11.6%
142	Asterixis	11.4%
143	Ballismus	11.4%
144	Mammary Neoplasms, Experimental	11.4%
145	Scrapie	11.4%
146	Polyradiculoneuropathy	11.3%
147	Polyradiculoneuritis	11.3%
148	Choroid Plexus Papilloma	11.3%
149	Trauma, Nervous System	11.2%
150	Brain Hemorrhage, Traumatic	11.2%
151	Cerebral Palsy	11.1%
152	Epilepsies, Partial	11.1%
153	Epilepsy, Generalized	11.1%
154	Pseudotumor Cerebri	11.1%
155	Hypertensive Encephalopathy	11.1%
156	Simple Partial Seizures	11.1%
157	Epilepsy, Reflex	11.1%
158	Headache Disorders, Primary	11.1%
159	Headache Disorders, Secondary	11.1%
160	Medication overuse headache	11.1%
161	Encephalomyelitis, Acute Disseminated	11%
162	Parathyroid Neoplasms	10.9%
163	Peritoneal Neoplasms	10.9%
164	Thyroid Neoplasm	10.9%
165	Thyroid carcinoma	10.9%
166	Cyst	10.9%
167	Neoplastic Processes	10.9%
168	Neoplastic Syndromes, Hereditary	10.9%
169	Neurologic Manifestations	10.9%
170	Pregnancy Complications, Neoplastic	10.9%
171	Neurotoxicity Syndromes	10.9%
172	Neoplasms, Experimental	10.8%
173	Ataxia Telangiectasia	10.8%
174	Carotid Artery Injuries	10.7%
175	Pituitary Apoplexy	10.7%
176	Brain Infarction	10.5%
177	Amnesia, Transient Global	10.5%
178	Chronic Fatigue Syndrome	10.3%
179	Vasculitis, Central Nervous System	10.3%
180	Meningitis, Bacterial	10.3%
181	Meningitis, Fungal	10.3%
182	Putaminal Hemorrhage	10.2%
183	Brain Injuries, Diffuse	10.2%
184	Traumatic Brain Injury	10.2%
185	Autonomic Dysreflexia	10%
186	Complex Regional Pain Syndromes	10%
187	Infarction, Middle Cerebral Artery	9.9%
188	Infarction, Anterior Cerebral Artery	9.9%
189	Infarction, Posterior Cerebral Artery	9.9%
190	Acanthoma	9.8%
191	Pancreatic Neoplasm	9.8%
192	Toxoplasmosis, Cerebral	9.8%
193	Meningeal Carcinomatosis	9.8%
194	Frontotemporal dementia	9.7%
195	Persistent Vegetative State	9.7%
196	Pituitary Diseases	9.6%
197	Sleep Wake Disorders	9.5%
198	Carcinoma 256, Walker	9.4%
199	Carotid Artery Diseases	9.3%
200	Brain Ischemia	9.3%
201	Cerebrovascular accident	9.3%
202	Kluver-Bucy Syndrome	9.3%
203	Vasospasm, Intracranial	9.3%
204	Intracranial Arterial Diseases	9.3%
205	Neoplasms, Radiation-Induced	9.3%
206	Tracheal Neoplasms	9.2%
207	Guillain-Barre Syndrome	9.1%
208	Prolactinoma	9.1%
209	Growth Hormone-Secreting Pituitary Adenoma	9.1%
210	Dyskinesia, Drug-Induced	9%
211	Carcinoma, Lobular	9%
212	Akathisia, Drug-Induced	8.9%
213	Cerebral Infarction	8.9%
214	Brain Stem Infarctions	8.9%
215	Carcinoma, Ehrlich Tumor	8.8%
216	Dermoid Cyst	8.8%
217	Carcinoma, Lewis Lung	8.8%
218	Peripheral Nerve Injuries	8.7%
219	Moyamoya Disease	8.6%
220	Myasthenia Gravis	8.6%
221	Trophoblastic Neoplasms	8.6%
222	Arachnoiditis	8.6%
223	Aseptic Meningitis	8.6%
224	Retroperitoneal Neoplasms	8.6%
225	Syringomyelia	8.6%
226	Essential Tremor	8.6%
227	Familial Tremor	8.6%
228	Pneumorrhachis	8.6%
229	Writer's Cramp	8.6%
230	Leukemia, Experimental	8.5%
231	Post-Traumatic Headache	8.5%
232	Tension Headache	8.5%
233	Epilepsy, Complex Partial	8.5%
234	Migraine Disorders	8.5%
235	Abdominal Migraine	8.5%
236	Status Migrainosus	8.5%
237	Cervicogenic Headache	8.5%
238	Multiple Endocrine Neoplasia Type 1	8.4%
239	Melanoma, Experimental	8.3%
240	Tuberculosis, Meningeal	8.2%
241	Myotonia Congenita	8.2%
242	Esophageal Neoplasms	8.1%
243	Lateral Medullary Syndrome	8%
244	Mitochondrial Encephalomyopathies	8%
245	Reye Syndrome	8%
246	Charcot-Marie-Tooth Disease	8%
247	Causalgia	7.9%
248	Intracranial Embolism and Thrombosis	7.9%
249	Hepatic Encephalopathy	7.9%
250	Neoplasms, Neuroepithelial	7.9%
251	Gliomatosis cerebri	7.9%
252	Subarachnoid Hemorrhage, Traumatic	7.9%
253	Carotid Artery, Internal, Dissection	7.9%
254	Neuromyelitis Optica	7.9%
255	Diffuse Axonal Injury	7.9%
256	Olfactory Nerve Injuries	7.8%
257	Adrenoleukodystrophy	7.7%
258	Neuroectodermal Tumors	7.7%
259	Sleep Disorders, Circadian Rhythm	7.7%
260	Sturge-Weber Syndrome	7.6%
261	Central Cord Syndrome	7.6%
262	Carcinoma, Pancreatic Ductal	7.6%
263	Refsum Disease	7.6%
264	Sarcoma, Experimental	7.5%
265	Leukemia, Radiation-Induced	7.5%
266	Thymoma	7.5%
267	Chorea	7.5%
268	Subacute Sclerosing Panencephalitis	7.5%
269	Botulism	7.5%
270	MELAS Syndrome	7.4%
271	Thyroid Nodule	7.4%
272	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.4%
273	Liver Neoplasms, Experimental	7.4%
274	Dysautonomia	7.3%
275	Erythroplasia	7.3%
276	Follicular cyst	7.3%
277	leukemia	7.3%
278	Mucocele	7.3%
279	Neoplasms, Germ Cell and Embryonal	7.3%
280	Neoplasms, Glandular and Epithelial	7.3%
281	Pilonidal Cyst	7.3%
282	Thyroglossal Cyst	7.3%
283	Synovial Cyst	7.3%
284	Vagus Nerve Disorder	7.3%
285	Glossopharyngeal Neuralgia	7.3%
286	Abducens Nerve Diseases	7.3%
287	Germ Cell Cancer	7.3%
288	Heavy Metal Poisoning, Nervous System	7.3%
289	Neuromuscular Junction Diseases	7.3%
290	Aberrant Crypt Foci	7.3%
291	Trochlear Nerve Diseases	7.3%
292	Peripheral Nervous System Diseases	7.3%
293	Testicular Neoplasms	7.3%
294	Vertebral Artery Dissection	7.3%
295	Mouth Neoplasms	7.2%
296	Vascular Neoplasms	7.2%
297	Central Nervous System Fungal Infections	7.2%
298	Conus Medullaris Syndrome	7.2%
299	Spinal Cord Vascular Diseases	7.2%
300	Thymus Neoplasms	7.2%
301	Auditory Perceptual Disorders	7.2%
302	Empty Sella Syndrome	7.2%
303	Hyperpituitarism	7.2%
304	Hypopituitarism	7.2%
305	Hypophysitis	7.2%
306	Cluster Headache	7.2%
307	Migraine with Aura	7.2%
308	Familial Hemiplegic Migraine	7.2%
309	Chronic Paroxysmal Hemicrania	7.2%
310	SUNCT Syndrome	7.2%
311	Paroxysmal Hemicrania	7.2%
312	Myotonic Dystrophy	7.2%
313	Genital Neoplasms, Female	7.1%
314	Brain Concussion	7.1%
315	Breast Neoplasms, Male	7.1%
316	Triple Negative Breast Neoplasms	7.1%
317	Medulloblastoma	7.1%
318	Cerebral Arterial Diseases	7%
319	Vertebrobasilar Insufficiency	7%
320	Basilar Artery Stenosis	7%
321	Vertebral Artery Stenosis	7%
322	Intracranial Hemorrhage, Hypertensive	7%
323	Transient Cerebral Ischemia	7%
324	Brain Diseases, Metabolic, Inborn	7%
325	melanoma	7%
326	Facial Nerve Injuries	6.9%
327	Brain Contusion	6.9%
328	Nelson Syndrome	6.9%
329	Nephroblastoma	6.8%
330	Alice in Wonderland Syndrome	6.8%
331	Neurofibrosarcoma	6.8%
332	Paraneoplastic Encephalomyelitis	6.7%
333	Horner Syndrome	6.6%
334	Leukoplakia, Oral	6.6%
335	Multiple Sclerosis	6.6%
336	Retinoblastoma	6.6%
337	Carcinosarcoma	6.6%
338	Hemangiosarcoma	6.6%
339	Leukemia L1210	6.6%
340	Leukemia P388	6.6%
341	lymphangiosarcoma	6.6%
342	Reflex Sympathetic Dystrophy	6.6%
343	Nocturnal Myoclonus Syndrome	6.6%
344	Choriocarcinoma	6.5%
345	Meningitis, Cryptococcal	6.5%
346	neurofibroma	6.5%
347	Torticollis	6.5%
348	Meningitis, Listeria	6.5%
349	Meningitis, Haemophilus	6.5%
350	Meningitis, Pneumococcal	6.5%
351	Myopathy	6.3%
352	Optic Neuropathy	6.3%
353	Adrenal Gland Neoplasms	6.2%
354	Gastrointestinal Neoplasms	6.2%
355	Genital Neoplasms, Male	6.2%
356	Liver neoplasms	6.2%
357	Uveal Neoplasms	6.2%
358	Central Nervous System Bacterial Infections	6.2%
359	Myasthenia Gravis, Autoimmune, Experimental	6.2%
360	Urologic Neoplasms	6.2%
361	Wernicke Encephalopathy	6.2%
362	Facial Nerve Diseases	6.2%
363	Craniocerebral Trauma	6.2%
364	Leukoplakia	6.2%
365	Lymphocele	6.2%
366	Pancreatic Cyst	6.2%
367	Parasomnia	6.2%
368	Dyssomnias	6.2%
369	AIDS Dementia Complex	6.2%
370	Paraneoplastic Syndromes	6.2%
371	Vipoma	6.1%
372	Sebaceous Gland Neoplasms	6.1%
373	Spinal Neoplasms	6.1%
374	Bone Marrow Neoplasms	6.1%
375	Lymphomatoid Granulomatosis	6.1%
376	Vestibulocochlear Nerve Diseases	6.1%
377	Barrett Esophagus	6.1%
378	Breast Cyst	6.1%
379	Decerebrate State	6.1%
380	Hemiparesis	6.1%
381	Histiocytic Disorders, Malignant	6.1%
382	Hydranencephaly	6.1%
383	Actinic keratosis	6.1%
384	Mediastinal Cyst	6.1%
385	Meningism	6.1%
386	Neoplasm Invasiveness	6.1%
387	Neoplasm Metastasis	6.1%
388	Neoplasm Recurrence, Local	6.1%
389	Neural Tube Defects	6.1%
390	Paresis	6.1%
391	Parovarian Cyst	6.1%
392	Pericardial Cyst	6.1%
393	Seizures	6.1%
394	Sensation Disorders	6.1%
395	Thymic Cyst	6.1%
396	Tethered Cord Syndrome	6.1%
397	Complex partial seizures	6.1%
398	Iniencephaly	6.1%
399	Craniorachischisis	6.1%
400	Exencephaly	6.1%
401	Monoparesis	6.1%
402	Septo-Optic Dysplasia	6.1%
403	Cortical Dysplasia	6.1%
404	Carcinogenesis	6.1%
405	Neurogenic Inflammation	6.1%
406	Gait Disorders, Neurologic	6.1%
407	Neuromuscular Manifestations	6.1%
408	Myxoid cyst	6.1%
409	Malformations of Cortical Development	6.1%
410	Metastasis	6.1%
411	Sweating, Gustatory	6.1%
412	Auriculotemporal Syndrome	6.1%
413	Carotid Stenosis	6.1%
414	Intracranial Aneurysm	6.1%
415	Intracranial Arteriosclerosis	6%
416	Cerebral Atherosclerosis	6%
417	Subarachnoid Hemorrhage	6%
418	Cerebral Arteriosclerosis	6%
419	Cerebral Hemorrhage	6%
420	Adenoma, Acidophil	6%
421	Ganglioneuroma	6%
422	Glioma	6%
423	Cerebral Thrombosis	6%
424	Malignant Glioma	6%
425	Intracranial Embolism	6%
426	Intracranial Thrombosis	6%
427	Sarcoma 180	6%
428	Hyperprolactinemia	6%
429	West Nile Fever	6%
430	Subclavian Steal Syndrome	5.9%
431	Pick Disease of the Brain	5.9%
432	Giant Cell Arteritis	5.9%
433	Temporal Arteritis	5.9%
434	Amyloid Neuropathies, Familial	5.9%
435	Jet Lag Syndrome	5.9%
436	insulinoma	5.8%
437	Ophthalmoplegia	5.8%
438	External Ophthalmoplegia	5.8%
439	Basal Cell Nevus Syndrome	5.8%
440	Hepatocellular Adenoma	5.7%
441	Composite Lymphoma	5.7%
442	Gastrinoma	5.6%
443	Glucagonoma	5.6%
444	Kernicterus	5.6%
445	Leukemia, Plasma Cell	5.6%
446	Acrodynia	5.6%
447	Tardive Dyskinesia	5.6%
448	Carcinoid Tumor	5.5%
449	Neurilemmoma	5.5%
450	Hutchinson's Melanotic Freckle	5.5%
451	Melanoma, Amelanotic	5.5%
452	Alstrom Syndrome	5.5%
453	Nose Neoplasms	5.5%
454	Basal cell carcinoma	5.4%
455	Carcinoma, Papillary	5.4%
456	Squamous cell carcinoma	5.4%
457	Chondrosarcoma	5.4%
458	Craniopharyngioma	5.4%
459	Cystadenoma	5.4%
460	leiomyosarcoma	5.4%
461	liposarcoma	5.4%
462	Mesothelioma	5.4%
463	Neuronal Ceroid-Lipofuscinoses	5.4%
464	synovial sarcoma	5.4%
465	Neuroectodermal Tumor, Melanotic	5.4%
466	Angiomyolipoma	5.4%
467	Clear Cell Sarcoma of Soft Tissue	5.4%
468	Alveolar Soft Part Sarcoma	5.4%
469	Neuroendocrine Tumors	5.4%
470	Brachial Plexus Neuritis	5.4%
471	Neuralgic Amyotrophy	5.4%
472	Sarcoma, Myeloid	5.4%
473	Carcinoma, Basal Cell	5.4%
474	Pupil Disorders	5.4%
475	Neurobehavioral Manifestations	5.4%
476	Carotid Artery Thrombosis	5.3%
477	Adenomatous Polyposis Coli	5.2%
478	Lymphoma	5.2%
479	Uveomeningoencephalitic Syndrome	5.2%
480	Palatal Neoplasms	5.2%
481	Vertigo	5.2%
482	Alcohol-Induced Disorders, Nervous System	5.2%
483	Vocal Cord Paralysis	5.2%
484	Corpus Luteum Cyst	5.2%
485	Ovarian Cysts	5.2%
486	Hematoma, Subdural	5.2%
487	Hematoma, Epidural, Cranial	5.2%
488	Acromegaly	5.1%
489	Cerebral Amyloid Angiopathy	5.1%
490	Astrocytoma	5.1%
491	Ependymoma	5.1%
492	oligodendroglioma	5.1%
493	Sinus Thrombosis, Intracranial	5.1%
494	Ganglioglioma	5.1%
495	gliosarcoma	5.1%
496	Anaplastic astrocytoma	5.1%
497	Anaplastic Oligodendroglioma	5.1%
498	Leydig Cell Tumor	5%
499	Cockayne Syndrome	5%
500	Paraneoplastic Cerebellar Degeneration	4.9%
501	Spinal Cord Ischemia	4.9%
502	Coma, Post-Head Injury	4.9%
503	Cerebrospinal Fluid Otorrhea	4.9%
504	Cerebrospinal Fluid Rhinorrhea	4.9%
505	Neuritis, Autoimmune, Experimental	4.9%
506	Gait Ataxia	4.9%
507	Cystadenocarcinoma	4.9%
508	Fibrosarcoma	4.9%
509	Osteosarcoma	4.9%
510	Tarsal Tunnel Syndrome	4.9%
511	Mucoepidermoid Carcinoma	4.9%
512	Cauda Equina Syndrome	4.9%
513	Tuberculosis, Central Nervous System	4.9%
514	Malignant Carcinoid Syndrome	4.8%
515	ovarian neoplasm	4.8%
516	Voice Disorders	4.7%
517	Voice Disturbance	4.7%
518	Multiple Sclerosis, Chronic Progressive	4.6%
519	Multiple Sclerosis, Relapsing-Remitting	4.6%
520	Choledochal Cyst	4.6%
521	Adenoma	4.6%
522	Ameloblastoma	4.6%
523	Angiokeratoma	4.6%
524	Carcinoma	4.6%
525	Chordoma	4.6%
526	Hemangioma	4.6%
527	hemangiopericytoma	4.6%
528	Lymphangioma	4.6%
529	Mesenchymoma	4.6%
530	Neuritis	4.6%
531	Nevus	4.6%
532	Polyneuritis	4.6%
533	Radiculitis	4.6%
534	Teratoma	4.6%
535	Polyneuropathy	4.6%
536	Hepatoblastoma	4.6%
537	Mixed Tumor, Mullerian	4.6%
538	Germinoma	4.6%
539	Teratocarcinoma	4.6%
540	Angiofibroma	4.6%
541	Mononeuritis	4.6%
542	Mononeuropathies	4.6%
543	Brachial Plexus Neuropathies	4.6%
544	Radiculopathy	4.6%
545	Mononeuropathy Multiplex	4.6%
546	Nerve Root Compression	4.6%
547	Sarcoma	4.6%
548	Epithelioma	4.6%
549	Adenofibroma	4.6%
550	Fibroadenoma	4.6%
551	Malignant Fibrous Histiocytoma	4.6%
552	Fabry Disease	4.6%
553	Glioblastoma	4.6%
554	Neuroblastoma	4.6%
555	Cavernous Sinus Thrombosis	4.6%
556	Sagittal Sinus Thrombosis	4.6%
557	Glioblastoma Multiforme	4.6%
558	Smith-Magenis syndrome	4.6%
559	Alcohol Withdrawal Seizures	4.6%
560	Dural Arteriovenous Fistula	4.6%
561	granulosa cell tumor	4.5%
562	Carcinoma, Ovarian Epithelial	4.5%
563	Mesoblastic Nephroma	4.5%
564	Peutz-Jeghers Syndrome	4.5%
565	Hematoma, Subdural, Intracranial	4.5%
566	Hematoma, Subdural, Chronic	4.5%
567	Hematoma, Subdural, Acute	4.5%
568	Zollinger-Ellison syndrome	4.5%
569	Endometrial Stromal Sarcoma	4.4%
570	Optic Atrophy, Hereditary, Leber	4.4%
571	Ganglioneuroblastoma	4.4%
572	Akathisia	4.4%
573	Restlessness	4.4%
574	Psychomotor Agitation	4.4%
575	Bowen's Disease	4.3%
576	Paraganglioma	4.3%
577	Rhabdomyosarcoma	4.3%
578	Giant Cell Tumor of Bone	4.3%
579	Ear Neoplasms	4.3%
580	Eyelid Neoplasms	4.3%
581	Lung Neoplasms	4.3%
582	Pleural Neoplasms	4.3%
583	Salivary Gland Neoplasms	4.2%
584	Tongue Neoplasms	4.2%
585	Neuroaspergillosis	4.2%
586	Galactosemias	4.2%
587	Urea Cycle Disorders, Inborn	4.2%
588	Tyrosinemias	4.2%
589	Carpal Tunnel Syndrome	4.2%
590	Uterine Neoplasms	4.2%
591	Vaginal Neoplasms	4.2%
592	Vulvar Neoplasms	4.2%
593	Uterine Cancer	4.2%
594	Fallopian Tube Neoplasms	4.2%
595	Hydatidiform Mole	4.2%
596	Sciatica	4.2%
597	Lymphangioleiomyomatosis	4.1%
598	Dermatofibrosarcoma	4%
599	Dermatofibrosarcoma Protuberans	4%
600	Reflex, Abnormal	4%
601	Hyporeflexia	4%
602	Hyperreflexia	4%
603	Brain Diseases	4%
604	Carcinoid Heart Disease	4%
605	Gait Apraxia	4%
606	Adrenocortical carcinoma	4%
607	Menkes Kinky Hair Syndrome	3.9%
608	Myositis	3.9%
609	Optic Atrophy	3.9%
610	Optic Neuritis	3.9%
611	Papilledema	3.9%
612	Strabismus	3.9%
613	Tolosa-Hunt Syndrome	3.9%
614	Isaacs syndrome	3.9%
615	Arsenic Poisoning	3.9%
616	Myotonic Disorders	3.9%
617	Myasthenic Syndromes, Congenital	3.9%
618	Homocystinuria	3.9%
619	Diabetic Neuropathies	3.8%
620	Facial Injuries	3.8%
621	Facial Neuralgia	3.8%
622	Pancreatic Pseudocyst	3.8%
623	Plasmacytoma	3.8%
624	Diabetic Amyotrophy	3.8%
625	Diabetic Autonomic Neuropathy	3.8%
626	Sleep Talking	3.8%
627	Manganese Poisoning	3.8%
628	Sleep Disorders, Intrinsic	3.8%
629	Orthostatic intolerance	3.8%
630	Pseudorabies	3.8%
631	Leigh Disease	3.8%
632	Anosmia	3.8%
633	Ataxia	3.8%
634	Athetosis	3.8%
635	Catalepsy	3.8%
636	Dystonia	3.8%
637	Hemiplegia	3.8%
638	Malignant histiocytosis	3.8%
639	Locked-In Syndrome	3.8%
640	Lymphatic Metastasis	3.8%
641	Meningomyelocele	3.8%
642	Muscle Hypertonia	3.8%
643	Muscle hypotonia	3.8%
644	Myoclonus	3.8%
645	Myotonia	3.8%
646	Neoplasms, Unknown Primary	3.8%
647	Neuralgia	3.8%
648	Paraplegia	3.8%
649	Pseudobulbar Palsy	3.8%
650	Quadriplegia	3.8%
651	Spasm	3.8%
652	Spastic Paraplegia	3.8%
653	Status Epilepticus	3.8%
654	Taste Disorders	3.8%
655	Tremor	3.8%
656	Spina Bifida	3.8%
657	Monoplegia	3.8%
658	Hypokinesia	3.8%
659	Leukemic Infiltration	3.8%
660	Paraparesis	3.8%
661	Bradykinesia	3.8%
662	Waxy flexibility	3.8%
663	Action Tremor	3.8%
664	Resting Tremor	3.8%
665	Dysosmia	3.8%
666	Quadriparesis	3.8%
667	Histiocytic sarcoma	3.8%
668	Mercury Poisoning, Nervous System	3.8%
669	Olfaction Disorders	3.8%
670	Myokymia	3.8%
671	Lead Poisoning, Nervous System	3.8%
672	Vestibular Neuronitis	3.8%
673	Somatosensory Disorders	3.8%
674	Neoplasm Micrometastasis	3.8%
675	Neuropathic pain	3.8%
676	Hyperkinesia	3.8%
677	Intention tremor	3.8%
678	Pharyngeal Neoplasms	3.8%
679	Anterior Spinal Artery Syndrome	3.8%
680	Pheochromocytoma	3.8%
681	Alveolar rhabdomyosarcoma	3.8%
682	Bile Duct Neoplasms	3.7%
683	gallbladder neoplasm	3.7%
684	Intestinal Neoplasms	3.7%
685	Penile Neoplasms	3.7%
686	Prostatic Neoplasms	3.7%
687	Stomach Neoplasms	3.7%
688	Cubital Tunnel Syndrome	3.7%
689	Neurosyphilis	3.7%
690	Polycythemia Vera	3.7%
691	Denys-Drash Syndrome	3.6%
692	Renal Cell Carcinoma	3.5%
693	Papillary Renal Cell Carcinoma	3.5%
694	Hand-Arm Vibration Syndrome	3.4%
695	Laryngeal neoplasm	3.4%
696	Vision Disorders	3.4%
697	Metamorphopsia	3.4%
698	Visual Impairment	3.4%
699	Fibromyalgia	3.4%
700	Optic Neuropathy, Ischemic	3.4%
701	Anterior Ischemic Optic Neuropathy	3.4%
702	Medial Tibial Stress Syndrome	3.4%
703	Facial Hemiatrophy	3.3%
704	Melkersson-Rosenthal Syndrome	3.3%
705	Mitochondrial Myopathies	3.3%
706	Anisocoria	3.3%
707	Confusion	3.3%
708	Facial paralysis	3.3%
709	Lethargy	3.3%
710	Memory Disorders	3.3%
711	Muscle Cramp	3.3%
712	Perceptual Disorders	3.3%
713	Psychomotor Disorders	3.3%
714	Tonic Pupil	3.3%
715	Eosinophilia-Myalgia Syndrome	3.3%
716	Anhedonia	3.3%
717	Disorientation	3.3%
718	Facial Paresis	3.3%
719	Memory Loss	3.3%
720	Hemisensory Neglect	3.3%
721	Dysacusis	3.3%
722	Bronchial Neoplasms	3.3%
723	Sleep Bruxism	3.3%
724	Toxoplasmosis, Congenital	3.3%
725	Anencephaly	3.3%
726	Meningocele	3.3%
727	Muscular Atrophy	3.3%
728	Respiratory Paralysis	3.3%
729	Encephalocele	3.3%
730	Malaria, Cerebral	3.3%
731	Multiple Pulmonary Nodules	3.3%
732	Bladder Neoplasm	3.3%
733	Kidney Neoplasm	3.3%
734	Ureteral Neoplasms	3.3%
735	Urethral Neoplasms	3.3%
736	Hodgkin Disease	3.3%
737	Lymphoma, Non-Hodgkin	3.3%
738	Tetany	3.3%
739	Adenocarcinoma	3.3%
740	Carcinoma in Situ	3.3%
741	Carcinoma, Transitional Cell	3.3%
742	Phyllodes Tumor	3.3%
743	Dysgerminoma	3.3%
744	Hemangioendothelioma	3.3%
745	Lipoma	3.3%
746	Myoma	3.3%
747	Myxoma	3.3%
748	Neuroma	3.3%
749	Papilloma	3.3%
750	Pseudomyxoma Peritonei	3.3%
751	Seminoma	3.3%
752	Sciatic Neuropathy	3.3%
753	Ulnar Neuropathies	3.3%
754	Lesion of Sciatic Nerve	3.3%
755	Papillomatosis	3.3%
756	Angiolipoma	3.3%
757	Myelolipoma	3.3%
758	Neoplasms, Bone Tissue	3.3%
759	Neoplasms, Fibrous Tissue	3.3%
760	Smooth Muscle Tumor	3.3%
761	Adenomatosis, Pulmonary	3.3%
762	Adenomatous Polyps	3.3%
763	Carcinoma, Large Cell	3.3%
764	Carcinoma, Small Cell	3.3%
765	Desmoplastic Small Round Cell Tumor	3.3%
766	Ulnar Neuritis	3.3%
767	Radial nerve compression	3.3%
768	Radial Tunnel Syndrome	3.3%
769	Peroneal Neuropathies	3.3%
770	Radial Neuropathy	3.3%
771	Median Neuropathy	3.3%
772	Sciatic Nerve Palsy	3.3%
773	Femoral Neuropathy	3.3%
774	Tibial Neuropathy	3.3%
775	Ulnar Nerve Palsy	3.3%
776	Chondroma	3.3%
777	Postural Orthostatic Tachycardia Syndrome	3.3%
778	Radial nerve palsy	3.3%
779	Enchondroma	3.3%
780	Polycystic Ovary Syndrome	3.3%
781	Neurocysticercosis	3.3%
782	Lyme Neuroborreliosis	3.2%
783	Waterhouse-Friderichsen Syndrome	3.2%
784	Nasopharyngeal carcinoma	3.2%
785	Endometrial Neoplasms	3.2%
786	Classical Lissencephalies and Subcortical Band Heterotopias	3.2%
787	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.2%
788	Carcinoma, Endometrioid	3.2%
789	Xeroderma Pigmentosum	3.1%
790	Zellweger Syndrome	3%
791	Duane Retraction Syndrome	2.9%
792	Glycogen storage disease type II	2.9%
793	Consciousness Disorders	2.9%
794	Mental Retardation	2.9%
795	Muscle Weakness	2.9%
796	Depressed Level of Consciousness	2.9%
797	Mental deficiency	2.9%
798	Intellectual Disability	2.9%
799	Mobius Syndrome	2.9%
800	Bell Palsy	2.9%
801	Catatonia	2.9%
802	Herpes Zoster Oticus	2.9%
803	Familial Periodic Paralysis	2.9%
804	Aphonia	2.9%
805	Sleep Deprivation	2.9%
806	Primary amyloidosis	2.9%
807	Dysphonia	2.9%
808	Hypopharyngeal Neoplasms	2.9%
809	Pleural Effusion, Malignant	2.9%
810	Hypopharyngeal Cancer	2.9%
811	Alexia	2.9%
812	Dyslexia	2.9%
813	Parotid Neoplasms	2.8%
814	Prostatic Neoplasms, Castration-Resistant	2.8%
815	Kearns-Sayre syndrome	2.8%
816	Thoracic Outlet Syndrome	2.8%
817	Esotropia	2.7%
818	Exotropia	2.7%
819	Hypotension, Orthostatic	2.7%
820	Sleep Apnea Syndromes	2.7%
821	Polymyositis	2.7%
822	Post-Exercise Hypotension	2.7%
823	Disorders of Excessive Somnolence	2.7%
824	Sleep Initiation and Maintenance Disorders	2.7%
825	Leukemia, Myelomonocytic, Chronic	2.7%
826	Night Terrors	2.7%
827	Somnambulism	2.7%
828	Trigeminal Nerve Disorder	2.7%
829	Transient Insomnia	2.7%
830	Sleep Paralysis	2.7%
831	Chronic Insomnia	2.7%
832	REM Sleep Behavior Disorder	2.7%
833	Hypersomnia	2.7%
834	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.7%
835	Dermal Sinus	2.7%
836	Dysgeusia	2.7%
837	Formication	2.7%
838	Hyperalgesia	2.7%
839	Hyperesthesia	2.7%
840	Hypesthesia	2.7%
841	Language Disorders	2.7%
842	Numbness	2.7%
843	Paresthesia	2.7%
844	Paraparesis, Spastic	2.7%
845	Spina Bifida Cystica	2.7%
846	Trismus	2.7%
847	Spina Bifida Occulta	2.7%
848	Epilepsia Partialis Continua	2.7%
849	Hypogeusia	2.7%
850	Brown-Sequard Syndrome	2.7%
851	Lissencephaly	2.7%
852	Polymicrogyria	2.7%
853	Pachygyria	2.7%
854	Schizencephaly	2.7%
855	Lockjaw	2.7%
856	Allodynia	2.7%
857	Lead Poisoning, Nervous System, Childhood	2.7%
858	Lead Poisoning, Nervous System, Adult	2.7%
859	Periventricular Nodular Heterotopia	2.7%
860	Ageusia	2.7%
861	Cerebellar Diseases	2.6%
862	Adenoid Cystic Carcinoma	2.6%
863	fibroma	2.6%
864	Fibromatosis	2.6%
865	Osteoblastoma	2.6%
866	Osteoma	2.6%
867	Polyradiculopathy	2.6%
868	Rhabdomyoma	2.6%
869	Chondromatosis	2.6%
870	Adenocarcinoma, Clear Cell	2.6%
871	Cholangiocarcinoma	2.6%
872	Cervical Intraepithelial Neoplasia	2.6%
873	Hemangioblastoma	2.6%
874	Lymphoma, Extranodal NK-T-Cell	2.6%
875	Myalgia	2.6%
876	Cecal Neoplasms	2.5%
877	Duodenal Neoplasms	2.5%
878	Gaucher Disease	2.5%
879	Tonsillar Neoplasms	2.4%
880	Eye Injuries	2.4%
881	Mastocytosis	2.4%
882	Muscular Dystrophy	2.4%
883	Congenital nystagmus	2.4%
884	Orbital Myositis	2.4%
885	Cell Transformation, Viral	2.4%
886	Diplopia	2.4%
887	Muscle Rigidity	2.4%
888	Muscle Spasticity	2.4%
889	Scotoma	2.4%
890	Photophobia	2.4%
891	Cogwheel Rigidity	2.4%
892	Hemifacial Spasm	2.4%
893	Amaurosis	2.4%
894	Blindness	2.4%
895	Nuchal Rigidity	2.4%
896	Gastrointestinal Stromal Tumors	2.3%
897	Pyomyositis	2.3%
898	Aicardi's syndrome	2.3%
899	Hemangioma, Cavernous	2.3%
900	Agnosia	2.3%
901	Apraxias	2.3%
902	Hallucinations	2.3%
903	Hemianopsia	2.3%
904	Hyperacusis	2.3%
905	Tinnitus	2.3%
906	Visual Agnosia	2.3%
907	Anosognosia	2.3%
908	Wernicke-Korsakoff Syndrome	2.3%
909	Phonophobia	2.3%
910	Hearing Loss	2.3%
911	Hoarseness	2.3%
912	Leukemia, T-Cell	2.3%
913	Leukemia, B-Cell	2.3%
914	Sarcopenia	2.3%
915	Lymphoma, Follicular	2.3%
916	T-Cell Lymphoma	2.3%
917	Mantle cell lymphoma	2.3%
918	Nasopharyngeal Neoplasms	2.3%
919	Waldenstrom Macroglobulinemia	2.3%
920	Multiple Myeloma	2.3%
921	Alcohol Withdrawal Delirium	2.3%
922	Fibromatosis, Aggressive	2.3%
923	Fibromatosis, Abdominal	2.3%
924	Klatskin Tumor	2.3%
925	Colorectal Neoplasms	2.3%
926	Tay-Sachs Disease	2.3%
927	Mastocytoma	2.2%
928	Mastocytosis, Systemic	2.2%
929	Sleep Apnea, Obstructive	2.2%
930	Sleep Apnea, Central	2.2%
931	Leukemia, Myeloid, Chronic-Phase	2.2%
932	Narcolepsy	2.2%
933	Trigeminal Neuralgia	2.2%
934	Kleine-Levin Syndrome	2.2%
935	Agraphia	2.2%
936	Anomia	2.2%
937	Cluttering	2.2%
938	Language Development Disorders	2.2%
939	Speech Disorders	2.2%
940	Syncope	2.2%
941	Stupor	2.2%
942	Dysgraphia	2.2%
943	Presyncope	2.2%
944	Dyslalia	2.2%
945	Niemann-Pick Disease, Type C	2.2%
946	Appendiceal Neoplasms	2.1%
947	Colonic Neoplasms	2.1%
948	Rectal Neoplasms	2.1%
949	Paranasal Sinus Neoplasms	2.1%
950	Holoprosencephaly	2.1%
951	Amnesia	2.1%
952	Delirium	2.1%
953	Dissociative Amnesia	2.1%
954	Color blindness	2.1%
955	Global Amnesia	2.1%
956	Cri-du-Chat Syndrome	2.1%
957	Down Syndrome	2.1%
958	Trisomy 21	2.1%
959	POEMS Syndrome	2%
960	Williams Syndrome	2%
961	Microcephaly	2%
962	Macrocephaly	2%
963	Hypokalemic periodic paralysis	2%
964	Porencephaly	2%
965	Cataplexy	1.9%
966	Aphasia	1.9%
967	Articulation Disorders	1.9%
968	Echolalia	1.9%
969	Stuttering	1.9%
970	Dysphasia	1.9%
971	Eye Burns	1.9%
972	Welander Distal Myopathy	1.9%
973	Amaurosis Fugax	1.9%
974	Blindness, Cortical	1.9%
975	Dyscalculia	1.9%
976	Rett Syndrome	1.9%
977	Deafness	1.8%
978	Hearing Loss, Sudden	1.8%
979	Gerstmann Syndrome	1.8%
980	Hearing Loss, Bilateral	1.8%
981	Hearing Loss, High-Frequency	1.8%
982	Hearing Loss, Mixed Conductive-Sensorineural	1.8%
983	Prosopagnosia	1.8%
984	Apraxia, Ideomotor	1.8%
985	Charles Bonnet Syndrome	1.8%
986	Hearing Loss, Unilateral	1.8%
987	Complete Hearing Loss	1.8%
988	Alien Hand Syndrome	1.8%
989	Deaf Mutism	1.8%
990	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.8%
991	Leukemia, Large Granular Lymphocytic	1.8%
992	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.8%
993	Lymphoma, T-Cell, Cutaneous	1.8%
994	Lymphoma, AIDS-Related	1.8%
995	Enteropathy-Associated T-Cell Lymphoma	1.8%
996	Primary Effusion Lymphoma	1.8%
997	Prader-Willi Syndrome	1.8%
998	Phantom pain	1.8%
999	Phantom Limb Pain	1.8%
1000	Maxillary Sinus Neoplasms	1.8%
1001	Anus Neoplasms	1.8%
1002	Sigmoid Neoplasms	1.8%
1003	Dysarthria	1.7%
1004	Dermatomyositis	1.7%
1005	Corneal Scar	1.7%
1006	Dupuytren Contracture	1.7%
1007	Mutism	1.6%
1008	Selective Mutism	1.6%
1009	Muscular Dystrophy, Duchenne	1.6%
1010	Urticaria Pigmentosa	1.6%
1011	Retrograde amnesia	1.6%
1012	Amnesia, Anterograde	1.6%
1013	Mycosis Fungoides	1.6%
1014	Lymphomatoid Papulosis	1.6%
1015	Plasmablastic lymphoma	1.6%
1016	Alexia, Pure	1.5%
1017	Rubinstein-Taybi Syndrome	1.5%
1018	Fragile X Syndrome	1.4%
1019	Burkitt Lymphoma	1.4%
1020	Corneal Perforation	1.4%
1021	Sezary Syndrome	1.3%
1022	Radicular Cyst	1.3%
1023	Mucopolysaccharidosis II	1.1%

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