MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Achlorhydria

(UMLS:C0001075)

Definition:: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
UMLS ID:: C0001075
MeSH ID:: D000126

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.405.748.045

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.076.087

Synonym(s)

Achlorhydria

ACHLORHYDRIA

Absent gastric acidity

Achlorhydria, gastric

Achylia gastrica

Anacidity, gastric

Gastric acidity, absent

Gastric anacidity

achlorhydria

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cyclosporine	FAERS: 2		US FAERS
2	Nexium 24hr	FAERS: 2		US FAERS
3	Ranitidine	FAERS: 2		US FAERS
4	1-N'-[2-[[5-[(Dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydron;chloride	FAERS: 1		US FAERS
5	Clonazepam	FAERS: 1		US FAERS
6	Esomeprazole	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
7	Ethosuximide	FAERS: 1		US FAERS
8	Lenalidomide	FAERS: 1		US FAERS
9	Omeprazole	FAERS: 1		US FAERS
10	Omeprazole	FAERS: 1	11422300	CTD US FAERS
11	Pantoprazole	FAERS: 1		US FAERS
12	Pantoprazole	FAERS: 1		US FAERS
13	Ranitidine	FAERS: 1		US FAERS
14	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
15	ledipasvir, sofosbuvir drug combination	FAERS: 1		US FAERS
16	Codeine			OFFSIDES
17	Fosinopril			OFFSIDES
18	Metolazone			OFFSIDES
19	Sodium Bicarbonate			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Gastritis	33.3%
2	Acidosis	31.1%
3	Alkalosis	31.1%
4	Gastric Dilatation	31.1%
5	Gastric outlet obstruction	31.1%
6	Metabolic acidosis	31.1%
7	Zollinger-Ellison syndrome	31%
8	Duodenogastric Reflux	30.6%
9	Peptic Ulcer	30.6%
10	Stomach Neoplasms	24.3%
11	Gastric Antral Vascular Ectasia	23.3%
12	Duodenal Ulcer	23.3%
13	Peptic Ulcer Perforation	23.3%
14	Gastric ulcer	23.3%
15	Gastroparesis	23.1%
16	Acidosis, Lactic	23.1%
17	Ketosis	23.1%
18	Pyloric Stenosis	23.1%
19	Ketonuria	23.1%
20	Ketoacidosis	23.1%
21	Ketonemia	23.1%
22	Wasting Syndrome	20.7%
23	Calcium Metabolism Disorders	20.5%
24	Iron Metabolism Disorders	20.5%
25	Esophageal Diseases	20.5%
26	Gastroenteritis	20.5%
27	Intestinal Diseases	20.5%
28	Phosphorus Metabolism Disorders	20.5%
29	Water-Electrolyte Imbalance	20.5%
30	Lipid Metabolism Disorders	20.5%
31	Mitochondrial Diseases	20.5%
32	Glucose Metabolism Disorders	20.5%
33	Dysentery	20%
34	Enteritis	20%
35	Enterocolitis	20%
36	Esophagitis	20%
37	Hypercalcemia	20%
38	Hypocalcemia	20%
39	Inflammatory Bowel Diseases	20%
40	Milk-Alkali Syndrome	20%
41	Proctocolitis	18.7%
42	Duodenitis	17.6%
43	Ileitis	17.6%
44	Erosive Duodenitis	17.6%
45	Diabetic Ketoacidosis	17.4%
46	Acidosis, Respiratory	17.4%
47	Alkalosis, Respiratory	17.4%
48	Celiac Disease	17.4%
49	Colitis	17.4%
50	Proctitis	17.4%
51	Sprue, Tropical	17.4%
52	Steatorrhea	17.4%
53	Sprue	17.4%
54	Dumping Syndrome	17.2%
55	Gastrointestinal Neoplasms	16.4%
56	Lactose Intolerance	16.4%
57	Lipodystrophy	16%
58	Colorectal Neoplasms	15.8%
59	Pseudohypoparathyroidism	15.6%
60	Osteopenia	15.5%
61	Intestinal Neoplasms	15.5%
62	Brain Diseases, Metabolic	15.3%
63	Gastrointestinal Hemorrhage	15.3%
64	Tuberculosis, Gastrointestinal	15%
65	Crohn Disease	14.8%
66	Duodenal Obstruction	14.8%
67	Enterocolitis, Neutropenic	14.8%
68	Necrotizing Enterocolitis	14.8%
69	Pouchitis	14.6%
70	Rickets	14.4%
71	Renal tubular acidosis	13.9%
72	Cecal Neoplasms	13.9%
73	Duodenal Neoplasms	13.9%
74	Appendicitis	13.9%
75	Leigh Disease	13.5%
76	Congenital Hyperinsulinism	13.5%
77	Amyloidosis	13.3%
78	Calcinosis	13.3%
79	Cecal Diseases	13.3%
80	Colonic Diseases	13.3%
81	Esophageal and Gastric Varices	13.3%
82	Esophageal Stenosis	13.3%
83	Hyperglycemia	13.3%
84	Hyperinsulinism	13.3%
85	Hyperkalemia	13.3%
86	Hypernatremia	13.3%
87	Hypoglycemia	13.3%
88	Hypokalemia	13.3%
89	Hyponatremia	13.3%
90	Ileal Diseases	13.3%
91	Intestinal Obstruction	13.3%
92	Intestinal Perforation	13.3%
93	Jejunal Diseases	13.3%
94	Pneumatosis Cystoides Intestinalis	13.3%
95	Rectal Diseases	13.3%
96	Xanthomatosis	13.3%
97	Hypophosphatemia	13.3%
98	Dyslipidemias	13.3%
99	Iron Overload	13.3%
100	Cronkhite-Canada Syndrome	13.3%
101	Xanthoma	13.3%
102	Intestinal Polyposis	13.3%
103	Esophageal Neoplasms	13.3%
104	Brain Diseases, Metabolic, Inborn	13.3%
105	Hyperhomocysteinemia	12.7%
106	Carbamoyl-Phosphate Synthase I Deficiency Disease	12.4%
107	Mesenteric vascular insufficiency	12.3%
108	Esophageal Atresia	12.2%
109	Intestinal Atresia	12.2%
110	Mesenteric Vascular Occlusion	12.2%
111	Hyperlipoproteinemia Type IV	12.1%
112	Hyperlipoproteinemia Type V	12.1%
113	Intestinal Fistula	12.1%
114	Enterocutaneous Fistula	12.1%
115	Rectal Fistula	12%
116	Anal Fistula	12%
117	Anus Neoplasms	12%
118	Sigmoid Neoplasms	12%
119	Biliary Tract Diseases	11.9%
120	Liver diseases	11.9%
121	Pancreatic Diseases	11.9%
122	Nutrition Disorders	11.9%
123	Enterocolitis, Pseudomembranous	11.8%
124	Hypolipoproteinemias	11.8%
125	pseudomembranous colitis	11.8%
126	Dysentery, Bacillary	11.8%
127	Colonic Pseudo-Obstruction	11.6%
128	Appendiceal Neoplasms	11.5%
129	Colonic Neoplasms	11.5%
130	Rectal Neoplasms	11.5%
131	Smith-Lemli-Opitz Syndrome	11%
132	Colitis, Ischemic	11%
133	Galactosemias	11%
134	Urea Cycle Disorders, Inborn	11%
135	Tyrosinemias	11%
136	Osteomalacia	10.9%
137	Hyperlipidemia, Familial Combined	10.7%
138	Familial Hypophosphatemic Rickets	10.7%
139	Reye Syndrome	10.6%
140	Gastrointestinal Stromal Tumors	10.6%
141	Diabetes Mellitus	10.5%
142	Esophageal Perforation	10.5%
143	Intestinal Diseases, Parasitic	10.5%
144	Nesidioblastosis	10.4%
145	Hyperlipoproteinemia Type III	10.2%
146	Barrett Esophagus	10.2%
147	Deglutition Disorders	10.2%
148	Dehydration	10.2%
149	Lipomatosis	10.2%
150	Water Intoxication	10.2%
151	Werner Syndrome	10.2%
152	Porphyrias, Hepatic	10.1%
153	Adenomatous Polyposis Coli	10.1%
154	Amino Acid Metabolism, Inborn Errors	10%
155	Bloom Syndrome	10%
156	Carbohydrate Metabolism, Inborn Errors	10%
157	Metal Metabolism, Inborn Errors	10%
158	Osteoporosis	10%
159	Progeria	10%
160	Lysosomal Storage Diseases	10%
161	Bone Demineralization, Pathologic	10%
162	Cytochrome-c Oxidase Deficiency	10%
163	Peroxisomal Disorders	10%
164	Post-Traumatic Osteoporosis	10%
165	Gaucher Disease	10%
166	Peptic Ulcer Hemorrhage	9.9%
167	Calciphylaxis	9.9%
168	Colonic Diseases, Functional	9.9%
169	Esophageal motility disorders	9.9%
170	Fecal Incontinence	9.9%
171	Fecal Impaction	9.9%
172	Hemosiderosis	9.9%
173	Intussusception	9.9%
174	Mallory-Weiss Syndrome	9.9%
175	Megacolon	9.9%
176	Vascular calcification	9.9%
177	Ileus	9.9%
178	Meconium ileus	9.9%
179	Hepatic Encephalopathy	9.9%
180	Mitochondrial Encephalomyopathies	9.9%
181	Hyperphosphaturia	9.7%
182	Hypoalphalipoproteinemias	9.7%
183	Glycogen storage disease type II	9.6%
184	Homocystinuria	9.3%
185	Zellweger Syndrome	9%
186	Tay-Sachs Disease	9%
187	Digestive System Neoplasms	8.9%
188	Amyloid Neuropathies, Familial	8.7%
189	Niemann-Pick Disease, Type C	8.5%
190	Hepatolenticular Degeneration	8.3%
191	Liver neoplasms	8.2%
192	Esophageal Achalasia	8.2%
193	Anal Fissure	8.2%
194	Hypercholesterolemia	8.2%
195	Hyperlipoproteinemias	8.2%
196	Hypertriglyceridemia	8.2%
197	Intestinal Pseudo-Obstruction	8.2%
198	Irritable Bowel Syndrome	8.2%
199	Superior Mesenteric Artery Syndrome	8.2%
200	Neurogenic Bowel	8.2%
201	Anal Ulcer	8.2%
202	Pancreatic Fistula	8.2%
203	Mitochondrial Myopathies	8.1%
204	Melena	8.1%
205	Myelinolysis, Central Pontine	8.1%
206	Glycosuria	7.9%
207	Hematemesis	7.9%
208	Fabry Disease	7.9%
209	Neuronal Ceroid-Lipofuscinoses	7.7%
210	Hemorrhoids	7.6%
211	Adrenoleukodystrophy	7.5%
212	HIV Wasting Syndrome	7.5%
213	MELAS Syndrome	7.5%
214	Adiposis Dolorosa	7.4%
215	Afferent Loop Syndrome	7.4%
216	Short Bowel Syndrome	7.4%
217	Rectocele	7.4%
218	Alkaptonuria	7.4%
219	Diverticulitis	7.4%
220	Glycogen Storage Disease	7.4%
221	Hypophosphatasia	7.4%
222	Insulin Resistance	7.4%
223	Osteoporosis, Postmenopausal	7.4%
224	Rectal Prolapse	7.4%
225	Propionic acidemia	7.4%
226	Dihydropyrimidine Dehydrogenase Deficiency	7.4%
227	Cystinosis	7.4%
228	HIV-Associated Lipodystrophy Syndrome	7.3%
229	Menkes Kinky Hair Syndrome	7.3%
230	Renal Osteodystrophy	7.3%
231	Renal rickets	7.3%
232	Variegate Porphyria	7.1%
233	Acute intermittent porphyria	7.1%
234	Porphyria Cutanea Tarda	7.1%
235	Biliary cirrhosis	6.9%
236	Mucopolysaccharidosis III	6.9%
237	Bile Duct Diseases	6.8%
238	Child Nutrition Disorders	6.8%
239	Cholelithiasis	6.8%
240	Chylous Ascites	6.8%
241	Fatty Liver	6.8%
242	Hepatitis	6.8%
243	Portal Hypertension	6.8%
244	Hypervitaminosis A	6.8%
245	Infant Nutrition Disorders	6.8%
246	Liver Cirrhosis	6.8%
247	Pancreatic Insufficiency	6.8%
248	Pancreatitis	6.8%
249	Peritoneal Neoplasms	6.8%
250	Pneumoperitoneum	6.8%
251	Malnutrition	6.8%
252	Focal Nodular Hyperplasia	6.8%
253	Hepatic Insufficiency	6.8%
254	Steatohepatitis	6.8%
255	Refsum Disease	6.7%
256	CREST Syndrome	6.7%
257	Cholecystolithiasis	6.7%
258	Wernicke Encephalopathy	6.6%
259	Bile Duct Neoplasms	6.6%
260	gallbladder neoplasm	6.6%
261	Necrobiosis Lipoidica Diabeticorum	6.6%
262	Fanconi Anemia	6.6%
263	Glycosuria, Renal	6.5%
264	Pruritus Ani	6.2%
265	Giardiasis	6.1%
266	Gestational Diabetes	6.1%
267	Latent Autoimmune Diabetes in Adults	6.1%
268	Glycogen Storage Disease Type I	6.1%
269	Glycogen Storage Disease Type V	6.1%
270	Diabetes Mellitus, Experimental	6%
271	Diverticulum	6%
272	Diverticulosis	6%
273	Nephrocalcinosis	5.9%
274	Tetany	5.9%
275	Pancreatic Neoplasm	5.9%
276	Cerebral Amyloid Angiopathy	5.8%
277	Choledocholithiasis	5.8%
278	Choledochal Cyst	5.7%
279	Laryngopharyngeal Reflux	5.6%
280	Friedreich Ataxia	5.6%
281	Liver Diseases, Parasitic	5.4%
282	Fatty Liver, Alcoholic	5.3%
283	Hepatitis, Alcoholic	5.3%
284	Liver Cirrhosis, Alcoholic	5.3%
285	Kearns-Sayre syndrome	5.3%
286	Hepatic Veno-Occlusive Disease	5.2%
287	Pancreatic Cyst	5.2%
288	Peliosis Hepatis	5.2%
289	Hepatopulmonary Syndrome	5.2%
290	Anus, Imperforate	5.1%
291	Hemoperitoneum	5.1%
292	Hepatomegaly	5.1%
293	Mesenteric Panniculitis	5.1%
294	Panniculitis, Peritoneal	5.1%
295	Peritonitis	5.1%
296	Peritoneal Fibrosis	5.1%
297	Encapsulating Peritoneal Sclerosis	5.1%
298	Anorectal Malformations	5.1%
299	Biliary Fistula	5%
300	Gastric Fistula	5%
301	Hepatic Vein Thrombosis	5%
302	Kernicterus	5%
303	Liver Abscess	5%
304	Budd-Chiari Syndrome	5%
305	Familial Periodic Paralysis	5%
306	Cockayne Syndrome	5%
307	Peutz-Jeghers Syndrome	5%
308	Primary amyloidosis	5%
309	Sjogren-Larsson Syndrome	4.9%
310	Renal Aminoacidurias	4.9%
311	Fanconi Syndrome	4.9%
312	Pseudohypoaldosteronism	4.9%
313	Liddle Syndrome	4.9%
314	Canavan Disease	4.9%
315	Alexander Disease	4.9%
316	Mucopolysaccharidosis II	4.8%
317	Ataxia Telangiectasia	4.5%
318	Cholangitis	4.4%
319	Cholecystitis	4.4%
320	Cholestasis	4.4%
321	Common Bile Duct Diseases	4.4%
322	Deficiency Diseases	4.4%
323	Hepatitis, Chronic	4.4%
324	Starvation	4.4%
325	Liver Failure	4.4%
326	Pancreatitis, Chronic	4.4%
327	Non-alcoholic Fatty Liver Disease	4.4%
328	Chronic active hepatitis	4.4%
329	Refeeding Syndrome	4.4%
330	Hepatocellular Adenoma	4.4%
331	Optic Atrophy, Hereditary, Leber	4.4%
332	Gout	4.3%
333	Amyotrophic Lateral Sclerosis	4.3%
334	Antley-Bixler Syndrome Phenotype	4.2%
335	Chemical and Drug Induced Liver Injury	4.2%
336	Hypokalemic periodic paralysis	4.1%
337	Frontotemporal dementia	4.1%
338	Cystinuria	4%
339	Hepatorenal Syndrome	4%
340	Xeroderma Pigmentosum	4%
341	Liver Abscess, Amebic	3.8%
342	Liver Neoplasms, Experimental	3.8%
343	Cryptosporidiosis	3.8%
344	Hepatitis, Animal	3.5%
345	Hepatitis, Viral, Human	3.5%
346	Arthritis, Gouty	3.5%
347	Cystic Fibrosis	3.5%
348	Liver Cirrhosis, Experimental	3.3%
349	Pancreatic Pseudocyst	3.3%
350	Albinism	3.3%
351	Pancreatitis, Alcoholic	3.3%
352	Cholestasis, Extrahepatic	3.3%
353	Biliary Dyskinesia	3.3%
354	Cholangitis, Sclerosing	3.3%
355	Kwashiorkor	3.3%
356	Magnesium Deficiency	3.3%
357	Potassium Deficiency	3.3%
358	Protein Deficiency	3.3%
359	Liver Failure, Acute	3.3%
360	Acalculous Cholecystitis	3.3%
361	Avitaminosis	3.3%
362	End Stage Liver Disease	3.3%
363	Hepatitis B, Chronic	3%
364	Hepatitis C, Chronic	3%
365	Carcinoma, Pancreatic Ductal	2.9%
366	Massive Hepatic Necrosis	2.7%
367	Ascorbic Acid Deficiency	2.7%
368	Vitamin A Deficiency	2.7%
369	Vitamin D Deficiency	2.7%
370	Vitamin E Deficiency	2.7%
371	Marasmus	2.7%
372	Emphysematous Cholecystitis	2.7%
373	Sphincter of Oddi Dysfunction	2.7%
374	Fascioliasis	2.7%
375	Ichthyosis, X-Linked	2.7%
376	Echinococcosis, Hepatic	2.7%
377	Chemical and Drug Induced Liver Injury, Chronic	2.7%
378	Autoimmune hepatitis	2.5%
379	Folic Acid Deficiency	2.5%
380	Pellagra	2.5%
381	Thiamine Deficiency	2.5%
382	Vitamin B 12 Deficiency	2.5%
383	Vitamin B 6 Deficiency	2.5%
384	Pyridoxine Deficiency	2.5%
385	insulinoma	2.4%
386	Gastrinoma	2.4%
387	Glucagonoma	2.4%
388	Beriberi	2.3%
389	Obesity	2.2%
390	Vipoma	2.1%
391	Hepatitis, Viral, Animal	2.1%
392	Hepatitis E	2%
393	Hepatitis B	2%
394	Hepatitis C	2%
395	Hepatitis A	2%
396	Obesity, Abdominal	1.9%
397	Anemia, Pernicious	1.7%
398	Vitamin K Deficiency	1.7%
399	Pediatric Obesity	1.6%
400	Scurvy	1.5%
401	Prader-Willi Syndrome	1.4%
402	Rift Valley Fever	1.1%
403	Subacute Combined Degeneration	1%

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