MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Miller Fisher Syndrome

(UMLS:C0393799)

Definition:: A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)
UMLS ID:: C0393799
MeSH ID:: D019846

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.114.750.100.500|C10.228.140.252.500|C10.292.562.350|C10.314.750.450.500|C10.668.829.350.500|C10.668.829.800.750.300.500

Classification 2:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.590.312

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.258.750.400.500

Synonym(s)

Miller Fisher Syndrome

Fisher Syndrome

Fisher syndrome

Fisher's syndrome

Miller Fisher syndrome

Miller-Fisher syndrome

Miller-Fisher variant of Guillain-Barre syndrome

Ophthalmoplegia, ataxia, areflexia syndrome

fisher miller syndrome

10.

fisher syndrome

11.

miller fisher syndrome

12.

miller-fisher syndrome

13.

syndrome miller fisher

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fingolimod Hydrochloride	FAERS: 2		US FAERS
2	pitavastatin	FAERS: 2		US FAERS
3	Baclofen	FAERS: 1		US FAERS
4	Capecitabine	FAERS: 1		US FAERS
5	Doxycycline	FAERS: 1		US FAERS
6	Lidoderm	FAERS: 1		US FAERS
7	Ofloxacin	FAERS: 1		US FAERS
8	Tacrolimus	FAERS: 1	15855240	CTD US FAERS
9	Triumeq	FAERS: 1		US FAERS
10	Zanamivir	FAERS: 1		US FAERS
11	empagliflozin	FAERS: 1		US FAERS
12	gemcitabine	FAERS: 1		US FAERS
13	ledipasvir, sofosbuvir drug combination	FAERS: 1		US FAERS
14	Diclofenac			OFFSIDES
15	fludarabine phosphate			OFFSIDES
16	fludarabine			OFFSIDES
17	gadoterate meglumine	Canada Vigilance: 1		Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	36.9%
2	Stiff-Person Syndrome	36.2%
3	Ophthalmoplegic Migraine	34.7%
4	Progressive supranuclear palsy	27.7%
5	Leukoencephalitis, Acute Hemorrhagic	26.8%
6	Multiple System Atrophy	26.6%
7	Opsoclonus-Myoclonus Syndrome	26.6%
8	Complex Regional Pain Syndromes	26.4%
9	Motor Neuron Disease	26.2%
10	Myasthenia Gravis	26%
11	Dandy-Walker Syndrome	25.9%
12	Neuromyelitis Optica	25%
13	Lambert-Eaton Myasthenic Syndrome	24.7%
14	Causalgia	24.2%
15	Meningoencephalitis	24.2%
16	Peripheral Nerve Injuries	24.2%
17	Subacute Combined Degeneration	24.1%
18	Cauda Equina Syndrome	23.6%
19	Ophthalmoplegia	23.2%
20	External Ophthalmoplegia	23.2%
21	Amyotrophic Lateral Sclerosis	22.6%
22	Myelitis, Transverse	22.4%
23	Lewy Body Disease	22.4%
24	Poliomyelitis	22.2%
25	Strabismus	21.8%
26	Tolosa-Hunt Syndrome	21.8%
27	Restless Legs Syndrome	21.7%
28	Encephalomyelitis	21.3%
29	Spinal Muscular Atrophy	21.3%
30	Progressive Muscular Atrophy	21.3%
31	Marchiafava-Bignami Disease	21.2%
32	Lupus Vasculitis, Central Nervous System	21.1%
33	Encephalomyelitis, Acute Disseminated	21%
34	Pneumocephalus	21%
35	Vasculitis, Central Nervous System	20.8%
36	Brachial Plexus Neuritis	20.7%
37	Neuralgic Amyotrophy	20.7%
38	Myasthenia Gravis, Autoimmune, Experimental	20.6%
39	Duane Retraction Syndrome	20.6%
40	Chronic Fatigue Syndrome	20.5%
41	Polyradiculoneuropathy	20.3%
42	Polyradiculoneuritis	20.3%
43	Leukoencephalopathy, Progressive Multifocal	20.2%
44	Chronobiology Disorders	20.1%
45	Ocular Motility Disorders	19.8%
46	Cyclophoria	19.8%
47	Myelinolysis, Central Pontine	19.3%
48	Guillain-Barre Syndrome	19.3%
49	Parkinson Disease	19.3%
50	Uveomeningoencephalitic Syndrome	19.1%
51	Dementia, Vascular	19%
52	Trauma, Nervous System	18.5%
53	Acrodynia	18.4%
54	Cerebellar Neoplasms	18.3%
55	Nervous System Neoplasms	18.3%
56	Neurologic Manifestations	18.3%
57	Neurotoxicity Syndromes	18.3%
58	Optic Neuropathy	18.3%
59	Neuritis	18.1%
60	Polyneuritis	18.1%
61	Radiculitis	18.1%
62	Mononeuritis	18.1%
63	Mononeuropathies	18.1%
64	Brachial Plexus Neuropathies	18.1%
65	Radiculopathy	18.1%
66	Mononeuropathy Multiplex	18.1%
67	Nerve Root Compression	18.1%
68	Neuritis, Autoimmune, Experimental	18.1%
69	Prion Diseases	18%
70	Neuromuscular Junction Diseases	17.8%
71	Tarsal Tunnel Syndrome	17.7%
72	Epidural Abscess	17.6%
73	Olfactory Nerve Injuries	17.6%
74	Striatonigral Degeneration	17.6%
75	Multiple Sclerosis	17.5%
76	Huntington Disease	17.2%
77	Subdural Effusion	17.1%
78	Demyelinating Diseases	16.8%
79	Demyelination	16.8%
80	Sleep Wake Disorders	16.8%
81	Spinal Cord Injuries	16.7%
82	Brain Abscess	16.6%
83	Epilepsy, Post-Traumatic	16.5%
84	Cranial nerve diseases	16.4%
85	Isaacs syndrome	16.4%
86	Myopathy	16.4%
87	Asterixis	16.4%
88	Ballismus	16.4%
89	Reflex Sympathetic Dystrophy	16.3%
90	Neuroleptic Malignant Syndrome	16.3%
91	Shy-Drager Syndrome	16.3%
92	Facial Nerve Injuries	16.3%
93	Diabetic Neuropathies	16.3%
94	Diabetic Amyotrophy	16.3%
95	Diabetic Autonomic Neuropathy	16.3%
96	Brain Injuries	16.3%
97	Neuralgia	16.2%
98	Neuropathic pain	16.2%
99	Brain Neoplasms	16.2%
100	Botulism	16.2%
101	Carpal Tunnel Syndrome	16.1%
102	Sciatica	16.1%
103	Dystonia Musculorum Deformans	16%
104	Autonomic Dysreflexia	16%
105	Paraneoplastic Cerebellar Degeneration	15.9%
106	Myelitis	15.9%
107	Parkinsonian Disorders	15.8%
108	Miller Fisher Syndrome	15.8%
109	MPTP Poisoning	15.8%
110	Esotropia	15.8%
111	Exotropia	15.8%
112	Cerebellar Ataxia	15.5%
113	Vagus Nerve Disorder	15.5%
114	Glossopharyngeal Neuralgia	15.5%
115	Abducens Nerve Diseases	15.5%
116	Trochlear Nerve Diseases	15.5%
117	Amblyopia	15.4%
118	Canavan Disease	15.4%
119	Alexander Disease	15.4%
120	Progressive bulbar palsy	15.4%
121	Bulbar palsy	15.4%
122	Dyskinesia, Drug-Induced	15.3%
123	Hand-Arm Vibration Syndrome	15.2%
124	Ataxia Telangiectasia	15%
125	Charcot-Marie-Tooth Disease	14.8%
126	Limbic Encephalitis	14.8%
127	Meningitis	14.7%
128	Movement Disorders	14.7%
129	Pachymeningitis	14.7%
130	Spinal Cord Diseases	14.7%
131	Polyradiculopathy	14.7%
132	Friedreich Ataxia	14.7%
133	Hepatolenticular Degeneration	14.6%
134	Congenital nystagmus	14.4%
135	Basal Ganglia Cerebrovascular Disease	14.4%
136	Facial Nerve Diseases	14%
137	Vestibulocochlear Nerve Diseases	13.9%
138	Akathisia, Drug-Induced	13.9%
139	Posterior Leukoencephalopathy Syndrome	13.8%
140	Posterior reversible encephalopathy syndrome	13.8%
141	Brain Hemorrhage, Traumatic	13.8%
142	Neuromuscular Diseases	13.7%
143	Sleep Disorders, Circadian Rhythm	13.6%
144	Central Nervous System Infection	13.5%
145	Cubital Tunnel Syndrome	13.4%
146	Central Nervous System Cysts	13.3%
147	Horner Syndrome	13.3%
148	Refsum Disease	13.2%
149	Leukomalacia, Periventricular	13.2%
150	Meige Syndrome	13.2%
151	Cerebral Ventriculitis	13.2%
152	Akinetic Mutism	13.2%
153	Anoxic Encephalopathy	13.2%
154	Basal Ganglia Diseases	13.2%
155	Brain Damage, Chronic	13.2%
156	Encephalitis	13.2%
157	Encephalomalacia	13.2%
158	Epilepsy	13.2%
159	Hydrocephalus	13.2%
160	Congenital Hydrocephalus	13.2%
161	Hypothalamic Diseases	13.2%
162	Thalamic Diseases	13.2%
163	Intracranial Hypertension	13.2%
164	Aura	13.2%
165	Leukoencephalopathy	13.2%
166	Neuroaxonal Dystrophies	13.2%
167	Headache Disorders	13.2%
168	Intracranial Hypotension	13.2%
169	Brain Edema	13.2%
170	Brain Hypoxia	13.2%
171	Aqueductal Stenosis	13.2%
172	Brain Death	13.1%
173	Pupil Disorders	12.9%
174	Carotid Artery Injuries	12.7%
175	Presenile dementia	12.6%
176	Senile dementia	12.6%
177	Spinal Cord Neoplasms	12.6%
178	Vascular Headaches	12.6%
179	Hypoxia-Ischemia, Brain	12.5%
180	Alstrom Syndrome	12.5%
181	Lafora Disease	12.4%
182	Unverricht-Lundborg Syndrome	12.4%
183	Polyneuropathy	12.4%
184	Pituitary Adenoma	12.2%
185	Pituitary Neoplasms	12.2%
186	POEMS Syndrome	12%
187	Meningitis, Bacterial	12%
188	Meningitis, Fungal	12%
189	Creutzfeldt-Jakob disease	12%
190	Kearns-Sayre syndrome	12%
191	Brain Diseases, Metabolic	12%
192	Cerebrovascular Disorders	12%
193	Cerebrovascular Insufficiency	12%
194	Dementia	12%
195	Basal Ganglia Hemorrhage	11.9%
196	Tuberous Sclerosis	11.9%
197	Myoclonic Epilepsy	11.8%
198	Epilepsy, Temporal Lobe	11.8%
199	Epilepsy, Rolandic	11.8%
200	Benign Rolandic Epilepsy	11.8%
201	Multiple Sclerosis, Chronic Progressive	11.7%
202	Multiple Sclerosis, Relapsing-Remitting	11.7%
203	Giant Cell Arteritis	11.5%
204	Temporal Arteritis	11.5%
205	Sciatic Neuropathy	11.5%
206	Ulnar Neuropathies	11.5%
207	Lesion of Sciatic Nerve	11.5%
208	Ulnar Neuritis	11.5%
209	Radial nerve compression	11.5%
210	Radial Tunnel Syndrome	11.5%
211	Peroneal Neuropathies	11.5%
212	Radial Neuropathy	11.5%
213	Median Neuropathy	11.5%
214	Sciatic Nerve Palsy	11.5%
215	Femoral Neuropathy	11.5%
216	Tibial Neuropathy	11.5%
217	Ulnar Nerve Palsy	11.5%
218	Radial nerve palsy	11.5%
219	Adrenoleukodystrophy	11.5%
220	Optic Nerve Glioma	11.5%
221	Toxoplasmosis, Cerebral	11.4%
222	Amnesia, Transient Global	11.4%
223	Vocal Cord Paralysis	11.3%
224	Optic Atrophy	11.3%
225	Optic Neuritis	11.3%
226	Papilledema	11.3%
227	Dysautonomia	11.1%
228	Heavy Metal Poisoning, Nervous System	11.1%
229	Tauopathies	11.1%
230	Myotonic Dystrophy	11.1%
231	Amyloid Neuropathies, Familial	10.8%
232	Mitochondrial Encephalomyopathies	10.8%
233	Brain Injuries, Diffuse	10.8%
234	Traumatic Brain Injury	10.8%
235	Supratentorial Neoplasms	10.8%
236	Jet Lag Syndrome	10.8%
237	Thoracic Outlet Syndrome	10.4%
238	Optic Neuropathy, Ischemic	10.3%
239	Anterior Ischemic Optic Neuropathy	10.3%
240	neurofibroma	10.3%
241	Scrapie	10.3%
242	Central Cord Syndrome	10.3%
243	Chorea	10.2%
244	Putaminal Hemorrhage	10.2%
245	Tuberculosis, Meningeal	10.1%
246	Myotonia Congenita	10.1%
247	Acoustic Neuroma	10.1%
248	Craniocerebral Trauma	10%
249	Parasomnia	10%
250	Dyssomnias	10%
251	Decerebrate State	10%
252	Hemiparesis	10%
253	Hydranencephaly	10%
254	Meningism	10%
255	Neural Tube Defects	10%
256	Paresis	10%
257	Seizures	10%
258	Sensation Disorders	10%
259	Tethered Cord Syndrome	10%
260	Central Nervous System Neoplasms	10%
261	Complex partial seizures	10%
262	Iniencephaly	10%
263	Craniorachischisis	10%
264	Exencephaly	10%
265	Monoparesis	10%
266	Septo-Optic Dysplasia	10%
267	Cortical Dysplasia	10%
268	Neurogenic Inflammation	10%
269	Gait Disorders, Neurologic	10%
270	Neuromuscular Manifestations	10%
271	Malformations of Cortical Development	10%
272	Nocturnal Myoclonus Syndrome	10%
273	Sweating, Gustatory	9.9%
274	Auriculotemporal Syndrome	9.9%
275	Pituitary Apoplexy	9.9%
276	Juvenile Myoclonic Epilepsy	9.9%
277	Myoclonic Epilepsies, Progressive	9.9%
278	Persistent Vegetative State	9.9%
279	Brain Infarction	9.9%
280	Infarction, Middle Cerebral Artery	9.8%
281	Infarction, Anterior Cerebral Artery	9.8%
282	Infarction, Posterior Cerebral Artery	9.8%
283	MELAS Syndrome	9.5%
284	Myositis	9.5%
285	Myotonic Disorders	9.5%
286	Myasthenic Syndromes, Congenital	9.5%
287	Neurobehavioral Manifestations	9.2%
288	Brain Diseases	9.2%
289	Brain Concussion	9.2%
290	Alice in Wonderland Syndrome	9.2%
291	Subarachnoid Hemorrhage, Traumatic	9.2%
292	Carotid Artery, Internal, Dissection	9.2%
293	Vision Disorders	9.2%
294	Metamorphopsia	9.2%
295	Visual Impairment	9.2%
296	Vertebral Artery Dissection	9.2%
297	Paraneoplastic Encephalomyelitis	9.1%
298	Sturge-Weber Syndrome	9.1%
299	Vertigo	9.1%
300	Alcohol-Induced Disorders, Nervous System	9.1%
301	Arachnoiditis	8.8%
302	Aseptic Meningitis	8.8%
303	Syringomyelia	8.8%
304	Essential Tremor	8.8%
305	Familial Tremor	8.8%
306	Pneumorrhachis	8.8%
307	Writer's Cramp	8.8%
308	Cerebral Palsy	8.8%
309	Epilepsies, Partial	8.8%
310	Epilepsy, Generalized	8.8%
311	Pseudotumor Cerebri	8.8%
312	Hypertensive Encephalopathy	8.8%
313	Simple Partial Seizures	8.8%
314	Epilepsy, Reflex	8.8%
315	Headache Disorders, Primary	8.8%
316	Headache Disorders, Secondary	8.8%
317	Medication overuse headache	8.8%
318	Subacute Sclerosing Panencephalitis	8.7%
319	Fibromyalgia	8.7%
320	Medial Tibial Stress Syndrome	8.7%
321	Mitochondrial Myopathies	8.6%
322	Eosinophilia-Myalgia Syndrome	8.6%
323	Facial Neuralgia	8.6%
324	Vestibular Neuronitis	8.6%
325	Alcohol Withdrawal Seizures	8.5%
326	Auditory Perceptual Disorders	8.5%
327	Voice Disorders	8.4%
328	Voice Disturbance	8.4%
329	Torticollis	8.4%
330	Moyamoya Disease	8.4%
331	Smith-Magenis syndrome	8.3%
332	Dural Arteriovenous Fistula	8.3%
333	Cerebrospinal Fluid Otorrhea	8.3%
334	Cerebrospinal Fluid Rhinorrhea	8.3%
335	Gait Ataxia	8.3%
336	Frontotemporal dementia	8.2%
337	Cerebral Infarction	8.2%
338	Brain Stem Infarctions	8.2%
339	Optic Atrophy, Hereditary, Leber	8.1%
340	Diffuse Axonal Injury	8.1%
341	Brain Stem Neoplasms	8.1%
342	Pituitary Diseases	8.1%
343	Orbital Myositis	8%
344	Central Nervous System Fungal Infections	8%
345	Conus Medullaris Syndrome	8%
346	Spinal Cord Vascular Diseases	8%
347	Carotid Artery Diseases	7.9%
348	Brain Ischemia	7.9%
349	Cerebrovascular accident	7.9%
350	Kluver-Bucy Syndrome	7.9%
351	Vasospasm, Intracranial	7.9%
352	Intracranial Arterial Diseases	7.9%
353	Facial Hemiatrophy	7.9%
354	Melkersson-Rosenthal Syndrome	7.9%
355	Familial Periodic Paralysis	7.9%
356	Anisocoria	7.9%
357	Tonic Pupil	7.9%
358	Meningitis, Cryptococcal	7.7%
359	Coma, Post-Head Injury	7.7%
360	Meningitis, Listeria	7.7%
361	Meningitis, Haemophilus	7.7%
362	Meningitis, Pneumococcal	7.7%
363	Peripheral Nervous System Diseases	7.7%
364	Akathisia	7.6%
365	Restlessness	7.6%
366	Psychomotor Agitation	7.6%
367	Reflex, Abnormal	7.6%
368	Hyporeflexia	7.6%
369	Hyperreflexia	7.6%
370	Brain Contusion	7.4%
371	Lateral Medullary Syndrome	7.4%
372	Eye Injuries	7.3%
373	Central Nervous System Bacterial Infections	7.3%
374	Myalgia	7.2%
375	Mobius Syndrome	7.2%
376	Bell Palsy	7.2%
377	Tardive Dyskinesia	7.2%
378	Reye Syndrome	7.2%
379	Herpes Zoster Oticus	7.2%
380	Intracranial Embolism and Thrombosis	7.2%
381	Hepatic Encephalopathy	7.2%
382	Color blindness	7.2%
383	West Nile Fever	7%
384	Corneal Scar	6.9%
385	Gait Apraxia	6.9%
386	Neurofibrosarcoma	6.8%
387	Kernicterus	6.8%
388	Choroid Plexus Papilloma	6.8%
389	AIDS Dementia Complex	6.7%
390	Brain Diseases, Metabolic, Inborn	6.6%
391	Post-Traumatic Headache	6.6%
392	Tension Headache	6.6%
393	Epilepsy, Complex Partial	6.6%
394	Migraine Disorders	6.6%
395	Abdominal Migraine	6.6%
396	Status Migrainosus	6.6%
397	Cervicogenic Headache	6.6%
398	Hematoma, Subdural	6.4%
399	Hematoma, Epidural, Cranial	6.4%
400	Aicardi's syndrome	6.2%
401	Retinal Dysplasia	6.2%
402	Polymyositis	6.1%
403	Wernicke Encephalopathy	6.1%
404	Diplopia	6%
405	Scotoma	6%
406	Photophobia	6%
407	Amaurosis	6%
408	Blindness	6%
409	Arsenic Poisoning	6%
410	Empty Sella Syndrome	6%
411	Hyperpituitarism	6%
412	Hypopituitarism	6%
413	Hypophysitis	6%
414	Facial Injuries	6%
415	Sleep Talking	6%
416	Manganese Poisoning	6%
417	Sleep Disorders, Intrinsic	6%
418	Orthostatic intolerance	6%
419	Anosmia	6%
420	Ataxia	6%
421	Athetosis	6%
422	Catalepsy	6%
423	Dystonia	6%
424	Hemiplegia	6%
425	Locked-In Syndrome	6%
426	Meningeal Neoplasms	6%
427	Meningomyelocele	6%
428	Muscle Hypertonia	6%
429	Muscle hypotonia	6%
430	Myoclonus	6%
431	Myotonia	6%
432	Paraplegia	6%
433	Pseudobulbar Palsy	6%
434	Quadriplegia	6%
435	Spasm	6%
436	Spastic Paraplegia	6%
437	Status Epilepticus	6%
438	Taste Disorders	6%
439	Tremor	6%
440	Spina Bifida	6%
441	Monoplegia	6%
442	Hypokinesia	6%
443	Paraparesis	6%
444	Bradykinesia	6%
445	Waxy flexibility	6%
446	Action Tremor	6%
447	Resting Tremor	6%
448	Dysosmia	6%
449	Quadriparesis	6%
450	Mercury Poisoning, Nervous System	6%
451	Olfaction Disorders	6%
452	Myokymia	6%
453	Lead Poisoning, Nervous System	6%
454	Somatosensory Disorders	6%
455	Hyperkinesia	6%
456	Intention tremor	6%
457	Trigeminal Nerve Disorder	5.9%
458	Cerebral Arterial Diseases	5.9%
459	Vertebrobasilar Insufficiency	5.9%
460	Basilar Artery Stenosis	5.9%
461	Vertebral Artery Stenosis	5.9%
462	Intracranial Hemorrhage, Hypertensive	5.9%
463	Transient Cerebral Ischemia	5.9%
464	Aniridia	5.6%
465	Muscular Dystrophy	5.6%
466	Pyomyositis	5.6%
467	Cerebellar Diseases	5.5%
468	Cluster Headache	5.5%
469	Migraine with Aura	5.5%
470	Familial Hemiplegic Migraine	5.5%
471	Chronic Paroxysmal Hemicrania	5.5%
472	SUNCT Syndrome	5.5%
473	Paroxysmal Hemicrania	5.5%
474	Confusion	5.5%
475	Facial paralysis	5.5%
476	Lethargy	5.5%
477	Memory Disorders	5.5%
478	Muscle Cramp	5.5%
479	Perceptual Disorders	5.5%
480	Psychomotor Disorders	5.5%
481	Anhedonia	5.5%
482	Disorientation	5.5%
483	Facial Paresis	5.5%
484	Memory Loss	5.5%
485	Hemisensory Neglect	5.5%
486	Dysacusis	5.5%
487	Sleep Bruxism	5.4%
488	Anencephaly	5.4%
489	Meningocele	5.4%
490	Muscular Atrophy	5.4%
491	Respiratory Paralysis	5.4%
492	Encephalocele	5.4%
493	Tetany	5.4%
494	Carotid Stenosis	5.4%
495	Intracranial Aneurysm	5.4%
496	Hemianopsia	5.4%
497	Intracranial Arteriosclerosis	5.4%
498	Cerebral Atherosclerosis	5.4%
499	Subarachnoid Hemorrhage	5.4%
500	Cerebral Arteriosclerosis	5.4%
501	Cerebral Hemorrhage	5.4%
502	Cerebral Thrombosis	5.4%
503	Intracranial Embolism	5.4%
504	Intracranial Thrombosis	5.4%
505	Graves Disease	5.4%
506	Corneal Perforation	5.4%
507	Classical Lissencephalies and Subcortical Band Heterotopias	5.3%
508	Retinal Degeneration	5.3%
509	Spinal Cord Ischemia	5.3%
510	Hematoma, Subdural, Intracranial	5.3%
511	Hematoma, Subdural, Chronic	5.3%
512	Hematoma, Subdural, Acute	5.3%
513	Tuberculosis, Central Nervous System	5.3%
514	Fabry Disease	5.1%
515	Hypokalemic periodic paralysis	5.1%
516	Consciousness Disorders	5%
517	Mental Retardation	5%
518	Muscle Weakness	5%
519	Depressed Level of Consciousness	5%
520	Mental deficiency	5%
521	Intellectual Disability	5%
522	Catatonia	5%
523	Aphonia	5%
524	Sleep Deprivation	5%
525	Dysphonia	5%
526	Hyperprolactinemia	5%
527	Menkes Kinky Hair Syndrome	5%
528	Subclavian Steal Syndrome	4.9%
529	Pick Disease of the Brain	4.9%
530	Antiphospholipid Syndrome	4.9%
531	Carotid Artery Thrombosis	4.9%
532	Neuroaspergillosis	4.8%
533	Blepharophimosis	4.8%
534	Uveal Neoplasms	4.8%
535	Eyelid Neoplasms	4.8%
536	Retinal Hemorrhage	4.8%
537	Keratoconjunctivitis Sicca	4.7%
538	Trigeminal Neuralgia	4.6%
539	Xerophthalmia	4.6%
540	Low Tension Glaucoma	4.6%
541	Iridocorneal endothelial syndrome	4.6%
542	Alexia	4.6%
543	Dyslexia	4.6%
544	Neuronal Ceroid-Lipofuscinoses	4.6%
545	Pseudorabies	4.5%
546	Acromegaly	4.5%
547	Chorioretinitis	4.5%
548	Amaurosis Fugax	4.5%
549	Blindness, Cortical	4.5%
550	Cerebral Amyloid Angiopathy	4.5%
551	Sinus Thrombosis, Intracranial	4.5%
552	Lupus Erythematosus, Systemic	4.5%
553	Overlap syndrome	4.5%
554	Asthenopia	4.5%
555	Conjunctival Diseases	4.5%
556	Corneal Diseases	4.5%
557	Eyelid Diseases	4.5%
558	Lacrimal Apparatus Diseases	4.5%
559	Lens Diseases	4.5%
560	Ocular Hypertension	4.5%
561	Ocular Hypotension	4.5%
562	Retinal Diseases	4.5%
563	Scleral Diseases	4.5%
564	Vitreous Detachment	4.5%
565	Posterior Vitreous Detachment	4.5%
566	Addison Disease	4.5%
567	Pemphigus	4.5%
568	Autoimmune thyroiditis	4.5%
569	Primary Adrenal Insufficiency	4.5%
570	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	4.4%
571	Autoimmune hepatitis	4.4%
572	Postural Orthostatic Tachycardia Syndrome	4.4%
573	Autoimmune Lymphoproliferative Syndrome	4.4%
574	Neurosyphilis	4.4%
575	Retinoblastoma	4.4%
576	Hoarseness	4.3%
577	Waterhouse-Friderichsen Syndrome	4.3%
578	Cockayne Syndrome	4.3%
579	Alcohol Withdrawal Delirium	4.3%
580	Galactosemias	4.2%
581	Urea Cycle Disorders, Inborn	4.2%
582	Tyrosinemias	4.2%
583	Pars Planitis	4.2%
584	Corneal Ulcer	4.2%
585	Trachoma	4.2%
586	Choroid Hemorrhage	4.2%
587	Welander Distal Myopathy	4.1%
588	Latent Autoimmune Diabetes in Adults	4.1%
589	Lyme Neuroborreliosis	4.1%
590	Dermatitis Herpetiformis	4.1%
591	Eye Abnormalities	4%
592	Eye Infection	4%
593	Eye Manifestations	4%
594	Eye Neoplasms	4%
595	Cavernous Sinus Thrombosis	4%
596	Sagittal Sinus Thrombosis	4%
597	Hypotension, Orthostatic	4%
598	Sleep Apnea Syndromes	4%
599	Post-Exercise Hypotension	4%
600	Holoprosencephaly	4%
601	Disorders of Excessive Somnolence	4%
602	Sleep Initiation and Maintenance Disorders	4%
603	Night Terrors	4%
604	Somnambulism	4%
605	Transient Insomnia	4%
606	Sleep Paralysis	4%
607	Chronic Insomnia	4%
608	REM Sleep Behavior Disorder	4%
609	Hypersomnia	4%
610	Dermal Sinus	4%
611	Dysgeusia	4%
612	Formication	4%
613	Hyperalgesia	4%
614	Hyperesthesia	4%
615	Hypesthesia	4%
616	Language Disorders	4%
617	Numbness	4%
618	Paresthesia	4%
619	Paraparesis, Spastic	4%
620	Spina Bifida Cystica	4%
621	Trismus	4%
622	Spina Bifida Occulta	4%
623	Epilepsia Partialis Continua	4%
624	Hypogeusia	4%
625	Meningeal Carcinomatosis	4%
626	Anterior Spinal Artery Syndrome	4%
627	Brown-Sequard Syndrome	4%
628	Lissencephaly	4%
629	Polymicrogyria	4%
630	Pachygyria	4%
631	Schizencephaly	4%
632	Lockjaw	4%
633	Allodynia	4%
634	Lead Poisoning, Nervous System, Childhood	4%
635	Lead Poisoning, Nervous System, Adult	4%
636	Periventricular Nodular Heterotopia	4%
637	Ageusia	4%
638	Homocystinuria	4%
639	Leigh Disease	3.9%
640	Autoimmune thrombocytopenia	3.9%
641	Immune thrombocytopenic purpura	3.9%
642	Keratoconjunctivitis	3.9%
643	Retinitis Pigmentosa	3.9%
644	Pigmentary retinopathy	3.9%
645	Hordeolum	3.8%
646	Prolactinoma	3.8%
647	Growth Hormone-Secreting Pituitary Adenoma	3.8%
648	Dermatomyositis	3.8%
649	Muscular Dystrophy, Duchenne	3.7%
650	Rheumatoid Arthritis	3.7%
651	Juvenile arthritis	3.7%
652	Nelson Syndrome	3.7%
653	Anti-Glomerular Basement Membrane Disease	3.7%
654	Muscle Rigidity	3.6%
655	Muscle Spasticity	3.6%
656	Toxoplasmosis, Congenital	3.6%
657	Cogwheel Rigidity	3.6%
658	Hemifacial Spasm	3.6%
659	Nuchal Rigidity	3.6%
660	Eye Hemorrhage	3.6%
661	Malaria, Cerebral	3.6%
662	Agnosia	3.6%
663	Apraxias	3.6%
664	Hallucinations	3.6%
665	Hyperacusis	3.6%
666	Tinnitus	3.6%
667	Visual Agnosia	3.6%
668	Anosognosia	3.6%
669	Wernicke-Korsakoff Syndrome	3.6%
670	Phonophobia	3.6%
671	Hearing Loss	3.6%
672	Neurocysticercosis	3.6%
673	Sarcopenia	3.6%
674	Choroiditis	3.4%
675	Iridocyclitis	3.4%
676	Iritis	3.4%
677	Amnesia	3.3%
678	Delirium	3.3%
679	Dissociative Amnesia	3.3%
680	Global Amnesia	3.3%
681	Cri-du-Chat Syndrome	3.3%
682	Down Syndrome	3.3%
683	Trisomy 21	3.3%
684	Meningioma	3.3%
685	Williams Syndrome	3.3%
686	Microcephaly	3.3%
687	Macrocephaly	3.3%
688	Zellweger Syndrome	3.3%
689	Porencephaly	3.3%
690	Acanthamoeba Keratitis	3.3%
691	Keratitis, Herpetic	3.3%
692	Cytomegalovirus Retinitis	3.3%
693	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.3%
694	Bacterial conjunctivitis	3.3%
695	Panophthalmitis	3.2%
696	Hypersensitivity	3.2%
697	Immunologic Deficiency Syndromes	3.2%
698	Immunoproliferative Disorders	3.2%
699	Immune reconstitution syndrome	3.2%
700	Immune Reconstitution Inflammatory Syndrome	3.2%
701	Sicca Syndrome	3.2%
702	Sjogren's Syndrome	3.2%
703	Prader-Willi Syndrome	3.1%
704	Glycogen storage disease type II	3.1%
705	Phantom pain	3.1%
706	Phantom Limb Pain	3.1%
707	Sleep Apnea, Obstructive	3%
708	Sleep Apnea, Central	3%
709	Narcolepsy	3%
710	Kleine-Levin Syndrome	3%
711	Agraphia	3%
712	Anomia	3%
713	Cluttering	3%
714	Language Development Disorders	3%
715	Speech Disorders	3%
716	Syncope	3%
717	Stupor	3%
718	Dysgraphia	3%
719	Presyncope	3%
720	Dyslalia	3%
721	Angioid Streaks	2.9%
722	Anisometropia	2.9%
723	Aphakia	2.9%
724	Astigmatism	2.9%
725	Blepharitis	2.9%
726	Blepharoptosis	2.9%
727	Blepharospasm	2.9%
728	Choroid Diseases	2.9%
729	Conjunctivitis	2.9%
730	Corneal edema	2.9%
731	Corneal Opacity	2.9%
732	Dacryocystitis	2.9%
733	Dry Eye Syndromes	2.9%
734	Ectropion	2.9%
735	Enophthalmos	2.9%
736	Entropion	2.9%
737	Episcleritis	2.9%
738	Exophthalmos	2.9%
739	Glaucoma	2.9%
740	Iris Diseases	2.9%
741	Keratitis	2.9%
742	Keratoconus	2.9%
743	Lacrimal Duct Obstruction	2.9%
744	Lens dislocation	2.9%
745	Lens Subluxation	2.9%
746	Mydriasis	2.9%
747	Myopia	2.9%
748	Presbyopia	2.9%
749	Pterygium	2.9%
750	Retinal Detachment	2.9%
751	Retinitis	2.9%
752	Scleritis	2.9%
753	Uveitis	2.9%
754	Corneal Neovascularization	2.9%
755	Orbital Pseudotumor	2.9%
756	Cataract	2.9%
757	Pinguecula	2.9%
758	Trichiasis	2.9%
759	Transfusion Reaction	2.9%
760	Hypotensive Transfusion Reaction	2.9%
761	Eye Burns	2.8%
762	Dyscalculia	2.7%
763	Rett Syndrome	2.7%
764	Deafness	2.7%
765	Hearing Loss, Sudden	2.7%
766	Gerstmann Syndrome	2.7%
767	Hearing Loss, Bilateral	2.7%
768	Hearing Loss, High-Frequency	2.7%
769	Hearing Loss, Mixed Conductive-Sensorineural	2.7%
770	Prosopagnosia	2.7%
771	Apraxia, Ideomotor	2.7%
772	Charles Bonnet Syndrome	2.7%
773	Hearing Loss, Unilateral	2.7%
774	Complete Hearing Loss	2.7%
775	Alien Hand Syndrome	2.7%
776	Deaf Mutism	2.7%
777	Rubinstein-Taybi Syndrome	2.7%
778	Anophthalmos	2.6%
779	Endophthalmitis	2.6%
780	Microphthalmos	2.6%
781	Pemphigoid, Benign Mucous Membrane	2.6%
782	Retinal Artery Occlusion	2.6%
783	Retinopathy of Prematurity	2.6%
784	Orbital Cellulitis	2.6%
785	Retinal Vasculitis	2.6%
786	Hypertensive Retinopathy	2.6%
787	Retrobulbar Hemorrhage	2.6%
788	Corneal Endothelial Cell Loss	2.6%
789	Hyphema	2.6%
790	Retinal Neovascularization	2.6%
791	Vitreous Hemorrhage	2.6%
792	Gaucher Disease	2.6%
793	Glomerulonephritis, Membranoproliferative	2.6%
794	Cataplexy	2.5%
795	Aphasia	2.5%
796	Articulation Disorders	2.5%
797	Echolalia	2.5%
798	Stuttering	2.5%
799	Dysphasia	2.5%
800	Retrograde amnesia	2.5%
801	Amnesia, Anterograde	2.5%
802	Retinal Vein Occlusion	2.4%
803	Diabetic Retinopathy	2.4%
804	Eye pain	2.4%
805	Tay-Sachs Disease	2.4%
806	Ophthalmia Neonatorum	2.3%
807	Fragile X Syndrome	2.3%
808	Niemann-Pick Disease, Type C	2.3%
809	Mutism	2.3%
810	Selective Mutism	2.3%
811	Dysarthria	2.3%
812	Granulomatosis with polyangiitis	2.2%
813	Angle Closure Glaucoma	2.2%
814	Glaucoma, Open-Angle	2.2%
815	Macular degeneration	2.2%
816	Panuveitis	2.2%
817	Retinal Drusen	2.2%
818	Retinal Necrosis Syndrome, Acute	2.2%
819	Retinoschisis	2.2%
820	Exfoliation Syndrome	2.2%
821	Thrombocytopenic purpura	2.2%
822	Alexia, Pure	2.1%
823	Felty Syndrome	2%
824	Lupus Nephritis	2%
825	Choroidal Neovascularization	2%
826	Rheumatoid Vasculitis	1.9%
827	Mucopolysaccharidosis II	1.9%
828	Anterior uveitis	1.8%
829	Uveitis, Posterior	1.8%
830	CHARGE Syndrome	1.8%
831	Herpes Zoster Ophthalmicus	1.8%
832	Albinism	1.8%
833	Immune Complex Diseases	1.6%
834	Latex allergy	1.6%
835	Mandibulofacial Dysostosis	1.6%
836	Environmental Illness	1.5%
837	Lymphoproliferative Disorders	1.5%
838	Paraproteinemias	1.5%
839	Lymphopenia	1.5%
840	Primary amyloidosis	1.4%
841	Monoclonal Gammopathy of Undetermined Significance	1.4%
842	Hypergammaglobulinemia	1.4%
843	Agammaglobulinemia	1.4%
844	Kounis Syndrome	1.4%
845	HIV Infections	1.3%
846	Transfusion-Related Acute Lung Injury	1.3%
847	Asthma, Aspirin-Induced	1.3%
848	Multiple Myeloma	1.2%
849	Serum Sickness	1.1%
850	Behcet Syndrome	1.1%
851	Hydrops Fetalis	1%
852	anaphylaxis	0.9%
853	Food Allergy	0.9%
854	Anaphylactic shock	0.9%
855	Respiratory Hypersensitivity	0.8%
856	Sick Building Syndrome	0.8%
857	Multiple Chemical Sensitivity	0.8%
858	Plasmacytoma	0.8%
859	Tumor Lysis Syndrome	0.8%
860	Urticaria	0.8%
861	Vasculitis, Leukocytoclastic, Cutaneous	0.8%
862	HTLV-I Infections	0.8%
863	Job Syndrome	0.8%
864	Sezary Syndrome	0.8%
865	Lymphoma	0.8%
866	Mastocytosis	0.7%
867	Drug Eruptions	0.7%
868	Chronic granulomatous disease	0.7%
869	Heavy Chain Disease	0.7%
870	Dermatitis, Allergic Contact	0.7%
871	HIV Seropositivity	0.7%
872	Acquired Immunodeficiency Syndrome	0.7%
873	AIDS related complex	0.7%
874	Infectious Mononucleosis	0.7%
875	Cryoglobulinemia	0.7%
876	AIDS-Related Opportunistic Infections	0.6%
877	Dermatitis, Atopic	0.6%
878	HIV Wasting Syndrome	0.6%
879	AIDS-Associated Nephropathy	0.6%
880	Waldenstrom Macroglobulinemia	0.6%
881	Wiskott-Aldrich Syndrome	0.6%
882	HIV-Associated Lipodystrophy Syndrome	0.6%
883	Milk Allergy	0.5%
884	Schnitzler Syndrome	0.5%
885	Wheat Hypersensitivity	0.5%
886	Mastocytosis, Systemic	0.5%
887	Angioedema	0.4%
888	Hodgkin Disease	0.4%
889	Leukemia, Plasma Cell	0.4%
890	Lymphoma, Non-Hodgkin	0.4%
891	Leukemia, T-Cell	0.4%
892	Acute Generalized Exanthematous Pustulosis	0.4%
893	Leukemia, B-Cell	0.4%
894	Asthma	0.4%
895	Composite Lymphoma	0.4%
896	Erythema Nodosum	0.4%
897	Dermatitis, Photoallergic	0.4%
898	Lymphangioleiomyomatosis	0.4%
899	Aspergillosis, Allergic Bronchopulmonary	0.4%
900	Toxic Epidermal Necrolysis	0.3%
901	Stevens-Johnson Syndrome	0.3%
902	Asthma, Exercise-Induced	0.3%
903	Status Asthmaticus	0.3%
904	Lymphoma, Follicular	0.3%
905	T-Cell Lymphoma	0.3%
906	Mantle cell lymphoma	0.3%
907	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.3%
908	Leukemia, Large Granular Lymphocytic	0.3%
909	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.3%
910	Asthma, Occupational	0.3%
911	Farmer's Lung	0.3%
912	Angioedemas, Hereditary	0.3%
913	Hay fever	0.3%
914	Rhinitis, Allergic, Perennial	0.3%
915	Hereditary Angioedema Type III	0.2%
916	Hereditary Angioedema Types I and II	0.2%
917	Lymphoma, T-Cell, Cutaneous	0.2%
918	Lymphoma, AIDS-Related	0.2%
919	Enteropathy-Associated T-Cell Lymphoma	0.2%
920	Primary Effusion Lymphoma	0.2%
921	Lymphomatoid Granulomatosis	0.2%
922	Burkitt Lymphoma	0.2%
923	Mycosis Fungoides	0.2%
924	Lymphomatoid Papulosis	0.2%
925	Plasmablastic lymphoma	0.2%

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