MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Multiple Sclerosis, Chronic Progressive

(UMLS:C0393665)

Definition:: A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
UMLS ID:: C0393665
MeSH ID:: D020528

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.114.375.500.200|C10.314.350.500.200

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.258.250.500.200

Synonym(s)

Multiple Sclerosis, Chronic Progressive

Chronic progressive multiple sclerosis

Multiple sclerosis (MS) progressive

Progressive multiple sclerosis

multiple sclerosis progressive

progressive multiple sclerosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	25-hydroxyvitamin D	26598277	CTD
2	Aluminum	17086897	CTD
3	Baclofen	19393848	CTD
4	Cyclophosphamide	11990877	CTD
5	Mitoxantrone	View details 11851027 15834643 16088176 16100967 16503747 17548442 19393848	CTD
6	Piracetam	19393848	CTD
7	Tacrolimus	7539635	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Multiple Sclerosis, Relapsing-Remitting	50.8%
2	Leukoencephalitis, Acute Hemorrhagic	36%
3	Neuromyelitis Optica	35.8%
4	Encephalomyelitis, Acute Disseminated	34%
5	Polyradiculoneuropathy	29.2%
6	Polyradiculoneuritis	29.2%
7	Stiff-Person Syndrome	25.5%
8	Myelitis, Transverse	25%
9	Myasthenia Gravis	24%
10	Uveomeningoencephalitic Syndrome	20.7%
11	Lambert-Eaton Myasthenic Syndrome	18.2%
12	Guillain-Barre Syndrome	17.7%
13	Myasthenia Gravis, Autoimmune, Experimental	17.7%
14	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	17.4%
15	Vasculitis, Central Nervous System	17.1%
16	Marchiafava-Bignami Disease	15.7%
17	Cranial nerve diseases	15.3%
18	Neuromuscular Diseases	15.3%
19	Chronobiology Disorders	15.3%
20	Subacute Combined Degeneration	14.9%
21	Motor Neuron Disease	13.4%
22	Ophthalmoplegic Migraine	13.3%
23	Myelinolysis, Central Pontine	13.2%
24	Trauma, Nervous System	12.7%
25	Nervous System Neoplasms	12.4%
26	Neurologic Manifestations	12.4%
27	Neurotoxicity Syndromes	12.4%
28	Neuritis, Autoimmune, Experimental	12.2%
29	Multiple System Atrophy	12.2%
30	Restless Legs Syndrome	11.7%
31	Miller Fisher Syndrome	11.7%
32	Ocular Motility Disorders	11.5%
33	Cyclophoria	11.5%
34	Antiphospholipid Syndrome	11.1%
35	Lupus Vasculitis, Central Nervous System	10.9%
36	Encephalomyelitis	10.6%
37	Prion Diseases	10.6%
38	Autonomic Dysreflexia	10.6%
39	Complex Regional Pain Syndromes	10.6%
40	Sleep Wake Disorders	10.5%
41	Amyotrophic Lateral Sclerosis	9.8%
42	Spinal Muscular Atrophy	9.8%
43	Progressive Muscular Atrophy	9.8%
44	Meningoencephalitis	9.3%
45	Parkinson Disease	9.2%
46	Spinal Cord Injuries	9.1%
47	Lupus Erythematosus, Systemic	9%
48	Overlap syndrome	9%
49	Leukoencephalopathy, Progressive Multifocal	8.9%
50	Peripheral Nerve Injuries	8.9%
51	Addison Disease	8.9%
52	Pemphigus	8.9%
53	Autoimmune thyroiditis	8.9%
54	Primary Adrenal Insufficiency	8.9%
55	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	8.9%
56	Autoimmune hepatitis	8.9%
57	Asterixis	8.8%
58	Ballismus	8.8%
59	Lewy Body Disease	8.6%
60	Dandy-Walker Syndrome	8.4%
61	Pneumocephalus	8.4%
62	Poliomyelitis	8.4%
63	Giant Cell Arteritis	8.3%
64	Temporal Arteritis	8.3%
65	Brain Diseases	8.2%
66	Dysautonomia	8.2%
67	Meningitis	8.2%
68	Movement Disorders	8.2%
69	Pachymeningitis	8.2%
70	Spinal Cord Diseases	8.2%
71	Vagus Nerve Disorder	8.2%
72	Glossopharyngeal Neuralgia	8.2%
73	Abducens Nerve Diseases	8.2%
74	Heavy Metal Poisoning, Nervous System	8.2%
75	Neuromuscular Junction Diseases	8.2%
76	Tauopathies	8.2%
77	Trochlear Nerve Diseases	8.2%
78	Peripheral Nervous System Diseases	8.2%
79	Chronic Fatigue Syndrome	7.9%
80	Striatonigral Degeneration	7.8%
81	Myelitis	7.8%
82	Progressive bulbar palsy	7.8%
83	Bulbar palsy	7.8%
84	Progressive supranuclear palsy	7.8%
85	Sleep Disorders, Circadian Rhythm	7.8%
86	Neuroleptic Malignant Syndrome	7.7%
87	Demyelinating Diseases	7.7%
88	Demyelination	7.7%
89	Autoimmune Lymphoproliferative Syndrome	7.6%
90	Causalgia	7.5%
91	Botulism	7.5%
92	Central Nervous System Cysts	7.5%
93	Latent Autoimmune Diabetes in Adults	7.5%
94	Dermatitis Herpetiformis	7.4%
95	Epidural Abscess	7.4%
96	Olfactory Nerve Injuries	7.4%
97	Dyskinesia, Drug-Induced	7.4%
98	Opsoclonus-Myoclonus Syndrome	7.2%
99	Hypersensitivity	7.2%
100	Immunologic Deficiency Syndromes	7.2%
101	Immunoproliferative Disorders	7.2%
102	Immune reconstitution syndrome	7.2%
103	Immune Reconstitution Inflammatory Syndrome	7.2%
104	MPTP Poisoning	7.2%
105	Canavan Disease	6.9%
106	Alexander Disease	6.9%
107	Shy-Drager Syndrome	6.9%
108	Central Nervous System Infection	6.9%
109	Myopathy	6.9%
110	Optic Neuropathy	6.9%
111	Facial Nerve Diseases	6.7%
112	Craniocerebral Trauma	6.7%
113	Parasomnia	6.7%
114	Dyssomnias	6.7%
115	Akathisia, Drug-Induced	6.6%
116	Vestibulocochlear Nerve Diseases	6.6%
117	Decerebrate State	6.6%
118	Hemiparesis	6.6%
119	Hydranencephaly	6.6%
120	Meningism	6.6%
121	Neural Tube Defects	6.6%
122	Paresis	6.6%
123	Seizures	6.6%
124	Sensation Disorders	6.6%
125	Tethered Cord Syndrome	6.6%
126	Central Nervous System Neoplasms	6.6%
127	Complex partial seizures	6.6%
128	Iniencephaly	6.6%
129	Craniorachischisis	6.6%
130	Exencephaly	6.6%
131	Monoparesis	6.6%
132	Septo-Optic Dysplasia	6.6%
133	Cortical Dysplasia	6.6%
134	Neurogenic Inflammation	6.6%
135	Gait Disorders, Neurologic	6.6%
136	Neuromuscular Manifestations	6.6%
137	Malformations of Cortical Development	6.6%
138	Sweating, Gustatory	6.6%
139	Auriculotemporal Syndrome	6.6%
140	Horner Syndrome	6.5%
141	Brain Injuries	6.5%
142	Facial Nerve Injuries	6.5%
143	Brain Neoplasms	6.5%
144	Spinal Cord Neoplasms	6.5%
145	Dystonia Musculorum Deformans	6.5%
146	Ataxia Telangiectasia	6.5%
147	Reflex Sympathetic Dystrophy	6.5%
148	Subdural Effusion	6.5%
149	Parkinsonian Disorders	6.5%
150	Nocturnal Myoclonus Syndrome	6.5%
151	Rheumatoid Arthritis	6.4%
152	Juvenile arthritis	6.4%
153	Graves Disease	6.4%
154	Anti-Glomerular Basement Membrane Disease	6.3%
155	Autoimmune thrombocytopenia	5.9%
156	Immune thrombocytopenic purpura	5.9%
157	Transfusion Reaction	5.8%
158	Hypotensive Transfusion Reaction	5.8%
159	Jet Lag Syndrome	5.7%
160	Pupil Disorders	5.7%
161	Neurobehavioral Manifestations	5.7%
162	Limbic Encephalitis	5.7%
163	Brain Abscess	5.6%
164	Ophthalmoplegia	5.6%
165	External Ophthalmoplegia	5.6%
166	Tuberous Sclerosis	5.6%
167	Paraneoplastic Encephalomyelitis	5.6%
168	Huntington Disease	5.5%
169	Epilepsy, Post-Traumatic	5.5%
170	Scrapie	5.5%
171	Sturge-Weber Syndrome	5.5%
172	Vertigo	5.5%
173	Central Cord Syndrome	5.5%
174	Alcohol-Induced Disorders, Nervous System	5.5%
175	Presenile dementia	5.4%
176	Senile dementia	5.4%
177	Meningitis, Bacterial	5.4%
178	Meningitis, Fungal	5.4%
179	Chorea	5.4%
180	Acrodynia	5.4%
181	Charcot-Marie-Tooth Disease	5.2%
182	Meige Syndrome	5.1%
183	Brachial Plexus Neuritis	5.1%
184	Neuralgic Amyotrophy	5.1%
185	Cerebral Ventriculitis	5.1%
186	Vocal Cord Paralysis	5%
187	Akinetic Mutism	4.9%
188	Anoxic Encephalopathy	4.9%
189	Arachnoiditis	4.9%
190	Basal Ganglia Diseases	4.9%
191	Brain Damage, Chronic	4.9%
192	Cerebellar Diseases	4.9%
193	Encephalitis	4.9%
194	Encephalomalacia	4.9%
195	Epilepsy	4.9%
196	Hydrocephalus	4.9%
197	Congenital Hydrocephalus	4.9%
198	Hypothalamic Diseases	4.9%
199	Aseptic Meningitis	4.9%
200	Neuritis	4.9%
201	Polyneuritis	4.9%
202	Radiculitis	4.9%
203	Syringomyelia	4.9%
204	Thalamic Diseases	4.9%
205	Intracranial Hypertension	4.9%
206	Polyneuropathy	4.9%
207	Mononeuritis	4.9%
208	Aura	4.9%
209	Leukoencephalopathy	4.9%
210	Essential Tremor	4.9%
211	Neuroaxonal Dystrophies	4.9%
212	Familial Tremor	4.9%
213	Headache Disorders	4.9%
214	Mononeuropathies	4.9%
215	Intracranial Hypotension	4.9%
216	Brachial Plexus Neuropathies	4.9%
217	Radiculopathy	4.9%
218	Mononeuropathy Multiplex	4.9%
219	Nerve Root Compression	4.9%
220	Brain Edema	4.9%
221	Brain Hypoxia	4.9%
222	Aqueductal Stenosis	4.9%
223	Pneumorrhachis	4.9%
224	Writer's Cramp	4.9%
225	Lafora Disease	4.8%
226	Unverricht-Lundborg Syndrome	4.8%
227	Voice Disorders	4.8%
228	Voice Disturbance	4.8%
229	Smith-Magenis syndrome	4.7%
230	Dural Arteriovenous Fistula	4.7%
231	Glomerulonephritis, Membranoproliferative	4.7%
232	Amblyopia	4.7%
233	Myotonia Congenita	4.7%
234	Dementia, Vascular	4.7%
235	Brain Hemorrhage, Traumatic	4.7%
236	Paraneoplastic Cerebellar Degeneration	4.6%
237	Cerebrospinal Fluid Otorrhea	4.6%
238	Cerebrospinal Fluid Rhinorrhea	4.6%
239	Gait Ataxia	4.6%
240	Brain Death	4.6%
241	Coma, Post-Head Injury	4.6%
242	Cerebellar Neoplasms	4.6%
243	Tarsal Tunnel Syndrome	4.5%
244	Cauda Equina Syndrome	4.5%
245	Posterior Leukoencephalopathy Syndrome	4.5%
246	Posterior reversible encephalopathy syndrome	4.5%
247	Friedreich Ataxia	4.4%
248	Hepatolenticular Degeneration	4.4%
249	Alcohol Withdrawal Seizures	4.3%
250	Creutzfeldt-Jakob disease	4.3%
251	Basal Ganglia Cerebrovascular Disease	4.3%
252	Carotid Artery Injuries	4.3%
253	Brain Injuries, Diffuse	4.3%
254	Traumatic Brain Injury	4.3%
255	Cerebellar Ataxia	4.3%
256	Supratentorial Neoplasms	4.3%
257	Torticollis	4.3%
258	Myotonic Dystrophy	4.2%
259	Reflex, Abnormal	4.1%
260	Hyporeflexia	4.1%
261	Hyperreflexia	4.1%
262	Granulomatosis with polyangiitis	4.1%
263	Akathisia	4%
264	Restlessness	4%
265	Psychomotor Agitation	4%
266	Tuberculosis, Meningeal	4%
267	Adrenoleukodystrophy	4%
268	Brain Diseases, Metabolic	4%
269	Cerebrovascular Disorders	4%
270	Myositis	4%
271	Optic Atrophy	4%
272	Optic Neuritis	4%
273	Papilledema	4%
274	Strabismus	4%
275	Tolosa-Hunt Syndrome	4%
276	Cerebrovascular Insufficiency	4%
277	Isaacs syndrome	4%
278	Arsenic Poisoning	4%
279	Dementia	4%
280	Myotonic Disorders	4%
281	Central Nervous System Fungal Infections	4%
282	Conus Medullaris Syndrome	4%
283	Myasthenic Syndromes, Congenital	4%
284	Spinal Cord Vascular Diseases	4%
285	Diabetic Neuropathies	3.9%
286	Facial Injuries	3.9%
287	Facial Neuralgia	3.9%
288	Diabetic Amyotrophy	3.9%
289	Diabetic Autonomic Neuropathy	3.9%
290	Sleep Talking	3.9%
291	Manganese Poisoning	3.9%
292	Sleep Disorders, Intrinsic	3.9%
293	Orthostatic intolerance	3.9%
294	Anosmia	3.9%
295	Ataxia	3.9%
296	Athetosis	3.9%
297	Catalepsy	3.9%
298	Dystonia	3.9%
299	Hemiplegia	3.9%
300	Locked-In Syndrome	3.9%
301	Meningeal Neoplasms	3.9%
302	Meningomyelocele	3.9%
303	Muscle Hypertonia	3.9%
304	Muscle hypotonia	3.9%
305	Myoclonus	3.9%
306	Myotonia	3.9%
307	Neuralgia	3.9%
308	Paraplegia	3.9%
309	Pseudobulbar Palsy	3.9%
310	Quadriplegia	3.9%
311	Spasm	3.9%
312	Spastic Paraplegia	3.9%
313	Status Epilepticus	3.9%
314	Taste Disorders	3.9%
315	Tremor	3.9%
316	Spina Bifida	3.9%
317	Monoplegia	3.9%
318	Hypokinesia	3.9%
319	Paraparesis	3.9%
320	Bradykinesia	3.9%
321	Waxy flexibility	3.9%
322	Action Tremor	3.9%
323	Resting Tremor	3.9%
324	Dysosmia	3.9%
325	Quadriparesis	3.9%
326	Mercury Poisoning, Nervous System	3.9%
327	Olfaction Disorders	3.9%
328	Myokymia	3.9%
329	Lead Poisoning, Nervous System	3.9%
330	Vestibular Neuronitis	3.9%
331	Somatosensory Disorders	3.9%
332	Neuropathic pain	3.9%
333	Hyperkinesia	3.9%
334	Intention tremor	3.9%
335	Myoclonic Epilepsy	3.8%
336	Epilepsy, Temporal Lobe	3.8%
337	Epilepsy, Rolandic	3.8%
338	Benign Rolandic Epilepsy	3.8%
339	Carpal Tunnel Syndrome	3.8%
340	Vascular Headaches	3.8%
341	Alice in Wonderland Syndrome	3.7%
342	neurofibroma	3.7%
343	Hypoxia-Ischemia, Brain	3.7%
344	Sciatica	3.7%
345	Tardive Dyskinesia	3.7%
346	Persistent Vegetative State	3.7%
347	Leukomalacia, Periventricular	3.7%
348	Immune Complex Diseases	3.7%
349	Latex allergy	3.7%
350	Optic Nerve Glioma	3.7%
351	Refsum Disease	3.7%
352	Vertebral Artery Dissection	3.6%
353	Amnesia, Transient Global	3.6%
354	Gait Apraxia	3.6%
355	Brain Concussion	3.6%
356	Toxoplasmosis, Cerebral	3.6%
357	Alstrom Syndrome	3.5%
358	Thrombocytopenic purpura	3.5%
359	Felty Syndrome	3.5%
360	Lupus Nephritis	3.5%
361	Hand-Arm Vibration Syndrome	3.4%
362	Vision Disorders	3.4%
363	Metamorphopsia	3.4%
364	Visual Impairment	3.4%
365	Fibromyalgia	3.3%
366	Optic Neuropathy, Ischemic	3.3%
367	Anterior Ischemic Optic Neuropathy	3.3%
368	Central Nervous System Bacterial Infections	3.3%
369	Medial Tibial Stress Syndrome	3.3%
370	Facial Hemiatrophy	3.3%
371	Melkersson-Rosenthal Syndrome	3.3%
372	Mitochondrial Myopathies	3.3%
373	Anisocoria	3.3%
374	Confusion	3.3%
375	Facial paralysis	3.3%
376	Lethargy	3.3%
377	Memory Disorders	3.3%
378	Muscle Cramp	3.3%
379	Perceptual Disorders	3.3%
380	Psychomotor Disorders	3.3%
381	Tonic Pupil	3.3%
382	Eosinophilia-Myalgia Syndrome	3.3%
383	Anhedonia	3.3%
384	Disorientation	3.3%
385	Facial Paresis	3.3%
386	Memory Loss	3.3%
387	Hemisensory Neglect	3.3%
388	Dysacusis	3.3%
389	Sleep Bruxism	3.3%
390	Pituitary Adenoma	3.3%
391	Pituitary Neoplasms	3.3%
392	Anencephaly	3.3%
393	Meningocele	3.3%
394	Multiple Sclerosis	3.3%
395	Muscular Atrophy	3.3%
396	Respiratory Paralysis	3.3%
397	Encephalocele	3.3%
398	Mitochondrial Encephalomyopathies	3.2%
399	Acoustic Neuroma	3.2%
400	Tetany	3.2%
401	Amyloid Neuropathies, Familial	3.2%
402	Meningitis, Cryptococcal	3.2%
403	Cerebral Palsy	3.2%
404	Epilepsies, Partial	3.2%
405	Epilepsy, Generalized	3.2%
406	Pseudotumor Cerebri	3.2%
407	Sciatic Neuropathy	3.2%
408	Hypertensive Encephalopathy	3.2%
409	Ulnar Neuropathies	3.2%
410	Lesion of Sciatic Nerve	3.2%
411	Simple Partial Seizures	3.2%
412	Epilepsy, Reflex	3.2%
413	Ulnar Neuritis	3.2%
414	Radial nerve compression	3.2%
415	Radial Tunnel Syndrome	3.2%
416	Peroneal Neuropathies	3.2%
417	Radial Neuropathy	3.2%
418	Median Neuropathy	3.2%
419	Sciatic Nerve Palsy	3.2%
420	Femoral Neuropathy	3.2%
421	Tibial Neuropathy	3.2%
422	Ulnar Nerve Palsy	3.2%
423	Postural Orthostatic Tachycardia Syndrome	3.2%
424	Radial nerve palsy	3.2%
425	Headache Disorders, Primary	3.2%
426	Headache Disorders, Secondary	3.2%
427	Medication overuse headache	3.2%
428	Meningitis, Listeria	3.2%
429	Meningitis, Haemophilus	3.2%
430	Meningitis, Pneumococcal	3.2%
431	Frontotemporal dementia	3.2%
432	Cubital Tunnel Syndrome	3.2%
433	Diffuse Axonal Injury	3.2%
434	Brain Stem Neoplasms	3.2%
435	Juvenile Myoclonic Epilepsy	3.2%
436	Myoclonic Epilepsies, Progressive	3.2%
437	Kernicterus	3.1%
438	Environmental Illness	3.1%
439	Rheumatoid Vasculitis	3%
440	POEMS Syndrome	3%
441	Basal Ganglia Hemorrhage	3%
442	Lymphoproliferative Disorders	3%
443	Paraproteinemias	3%
444	Lymphopenia	3%
445	Auditory Perceptual Disorders	2.9%
446	Subarachnoid Hemorrhage, Traumatic	2.9%
447	Carotid Artery, Internal, Dissection	2.9%
448	Duane Retraction Syndrome	2.9%
449	Consciousness Disorders	2.9%
450	Mental Retardation	2.9%
451	Muscle Weakness	2.9%
452	Depressed Level of Consciousness	2.9%
453	Mental deficiency	2.9%
454	Intellectual Disability	2.9%
455	Mobius Syndrome	2.8%
456	Bell Palsy	2.8%
457	Catatonia	2.8%
458	Herpes Zoster Oticus	2.8%
459	Familial Periodic Paralysis	2.8%
460	Aphonia	2.8%
461	Sleep Deprivation	2.8%
462	Dysphonia	2.8%
463	Classical Lissencephalies and Subcortical Band Heterotopias	2.8%
464	Pituitary Apoplexy	2.8%
465	Subacute Sclerosing Panencephalitis	2.8%
466	Brain Contusion	2.8%
467	Brain Infarction	2.7%
468	Sicca Syndrome	2.7%
469	Sjogren's Syndrome	2.7%
470	Pituitary Diseases	2.7%
471	Choroid Plexus Papilloma	2.6%
472	AIDS Dementia Complex	2.6%
473	Thoracic Outlet Syndrome	2.6%
474	Carotid Artery Diseases	2.6%
475	Brain Ischemia	2.6%
476	Esotropia	2.6%
477	Exotropia	2.6%
478	Hypotension, Orthostatic	2.6%
479	Sleep Apnea Syndromes	2.6%
480	Cerebrovascular accident	2.6%
481	Polymyositis	2.6%
482	Kluver-Bucy Syndrome	2.6%
483	Vasospasm, Intracranial	2.6%
484	Spinal Cord Ischemia	2.6%
485	Intracranial Arterial Diseases	2.6%
486	Post-Exercise Hypotension	2.6%
487	Disorders of Excessive Somnolence	2.6%
488	Sleep Initiation and Maintenance Disorders	2.6%
489	Night Terrors	2.6%
490	Somnambulism	2.6%
491	Trigeminal Nerve Disorder	2.6%
492	Transient Insomnia	2.6%
493	Sleep Paralysis	2.6%
494	Chronic Insomnia	2.6%
495	REM Sleep Behavior Disorder	2.6%
496	Hypersomnia	2.6%
497	Dermal Sinus	2.6%
498	Dysgeusia	2.6%
499	Formication	2.6%
500	Hyperalgesia	2.6%
501	Hyperesthesia	2.6%
502	Hypesthesia	2.6%
503	Language Disorders	2.6%
504	Numbness	2.6%
505	Paresthesia	2.6%
506	Paraparesis, Spastic	2.6%
507	Spina Bifida Cystica	2.6%
508	Trismus	2.6%
509	Spina Bifida Occulta	2.6%
510	Epilepsia Partialis Continua	2.6%
511	Hypogeusia	2.6%
512	Meningeal Carcinomatosis	2.6%
513	Brown-Sequard Syndrome	2.6%
514	Lissencephaly	2.6%
515	Polymicrogyria	2.6%
516	Pachygyria	2.6%
517	Schizencephaly	2.6%
518	Lockjaw	2.6%
519	Allodynia	2.6%
520	Lead Poisoning, Nervous System, Childhood	2.6%
521	Lead Poisoning, Nervous System, Adult	2.6%
522	Periventricular Nodular Heterotopia	2.6%
523	Ageusia	2.6%
524	Tuberculosis, Central Nervous System	2.6%
525	Putaminal Hemorrhage	2.6%
526	Hypergammaglobulinemia	2.5%
527	Agammaglobulinemia	2.5%
528	Kounis Syndrome	2.5%
529	HIV Infections	2.5%
530	Transfusion-Related Acute Lung Injury	2.5%
531	Infarction, Middle Cerebral Artery	2.5%
532	Infarction, Anterior Cerebral Artery	2.5%
533	Infarction, Posterior Cerebral Artery	2.5%
534	Myalgia	2.4%
535	Neuronal Ceroid-Lipofuscinoses	2.4%
536	MELAS Syndrome	2.4%
537	Alexia	2.4%
538	Polyradiculopathy	2.4%
539	Post-Traumatic Headache	2.4%
540	Tension Headache	2.4%
541	Epilepsy, Complex Partial	2.4%
542	Migraine Disorders	2.4%
543	Abdominal Migraine	2.4%
544	Status Migrainosus	2.4%
545	Cervicogenic Headache	2.4%
546	Dyslexia	2.4%
547	Primary amyloidosis	2.3%
548	Monoclonal Gammopathy of Undetermined Significance	2.3%
549	Hematoma, Subdural	2.3%
550	Hematoma, Epidural, Cranial	2.3%
551	Cerebral Infarction	2.3%
552	Brain Stem Infarctions	2.3%
553	Optic Atrophy, Hereditary, Leber	2.3%
554	Eye Injuries	2.2%
555	Kearns-Sayre syndrome	2.2%
556	Aicardi's syndrome	2.2%
557	Moyamoya Disease	2.2%
558	Hoarseness	2.2%
559	Muscular Dystrophy	2.2%
560	Congenital nystagmus	2.2%
561	Orbital Myositis	2.2%
562	Neurofibrosarcoma	2.2%
563	Cockayne Syndrome	2.2%
564	Alcohol Withdrawal Delirium	2.2%
565	Diplopia	2.2%
566	Muscle Rigidity	2.2%
567	Muscle Spasticity	2.2%
568	Scotoma	2.2%
569	Photophobia	2.2%
570	Cogwheel Rigidity	2.2%
571	Hemifacial Spasm	2.2%
572	Amaurosis	2.2%
573	Blindness	2.2%
574	Nuchal Rigidity	2.2%
575	Reye Syndrome	2.2%
576	Neuroaspergillosis	2.2%
577	Pyomyositis	2.2%
578	Intracranial Embolism and Thrombosis	2.2%
579	Hepatic Encephalopathy	2.2%
580	Agnosia	2.2%
581	Apraxias	2.2%
582	Hallucinations	2.2%
583	Hemianopsia	2.2%
584	Hyperacusis	2.2%
585	Tinnitus	2.2%
586	Visual Agnosia	2.2%
587	Anosognosia	2.2%
588	Wernicke-Korsakoff Syndrome	2.2%
589	Phonophobia	2.2%
590	Hearing Loss	2.2%
591	Multiple Sclerosis, Chronic Progressive	2.1%
592	Sarcopenia	2.1%
593	West Nile Fever	2.1%
594	Asthma, Aspirin-Induced	2.1%
595	Lateral Medullary Syndrome	2%
596	anaphylaxis	2%
597	Food Allergy	2%
598	Anaphylactic shock	2%
599	Cluster Headache	2%
600	Migraine with Aura	2%
601	Familial Hemiplegic Migraine	2%
602	Chronic Paroxysmal Hemicrania	2%
603	SUNCT Syndrome	2%
604	Paroxysmal Hemicrania	2%
605	Holoprosencephaly	2%
606	Empty Sella Syndrome	2%
607	Hyperpituitarism	2%
608	Hypopituitarism	2%
609	Hypophysitis	2%
610	Pseudorabies	1.9%
611	Cerebral Arterial Diseases	1.9%
612	Vertebrobasilar Insufficiency	1.9%
613	Anterior Spinal Artery Syndrome	1.9%
614	Basilar Artery Stenosis	1.9%
615	Vertebral Artery Stenosis	1.9%
616	Sleep Apnea, Obstructive	1.9%
617	Sleep Apnea, Central	1.9%
618	Intracranial Hemorrhage, Hypertensive	1.9%
619	Transient Cerebral Ischemia	1.9%
620	Narcolepsy	1.9%
621	Trigeminal Neuralgia	1.9%
622	Kleine-Levin Syndrome	1.9%
623	Agraphia	1.9%
624	Anomia	1.9%
625	Cluttering	1.9%
626	Language Development Disorders	1.9%
627	Speech Disorders	1.9%
628	Syncope	1.9%
629	Stupor	1.9%
630	Dysgraphia	1.9%
631	Presyncope	1.9%
632	Dyslalia	1.9%
633	Amnesia	1.9%
634	Delirium	1.9%
635	Dissociative Amnesia	1.9%
636	Color blindness	1.9%
637	Global Amnesia	1.9%
638	Cri-du-Chat Syndrome	1.9%
639	Down Syndrome	1.9%
640	Brain Diseases, Metabolic, Inborn	1.9%
641	Trisomy 21	1.9%
642	Hematoma, Subdural, Intracranial	1.9%
643	Hematoma, Subdural, Chronic	1.9%
644	Hematoma, Subdural, Acute	1.9%
645	Meningioma	1.9%
646	Williams Syndrome	1.9%
647	Serum Sickness	1.8%
648	Microcephaly	1.8%
649	Macrocephaly	1.8%
650	Neurosyphilis	1.8%
651	Hypokalemic periodic paralysis	1.8%
652	Porencephaly	1.8%
653	Multiple Myeloma	1.8%
654	Respiratory Hypersensitivity	1.7%
655	Sick Building Syndrome	1.7%
656	Multiple Chemical Sensitivity	1.7%
657	Toxoplasmosis, Congenital	1.6%
658	Prader-Willi Syndrome	1.6%
659	Plasmacytoma	1.6%
660	Tumor Lysis Syndrome	1.6%
661	Urticaria	1.6%
662	Vasculitis, Leukocytoclastic, Cutaneous	1.6%
663	Eye Burns	1.6%
664	Wernicke Encephalopathy	1.6%
665	Malaria, Cerebral	1.6%
666	HTLV-I Infections	1.6%
667	Job Syndrome	1.6%
668	Carotid Stenosis	1.6%
669	Intracranial Aneurysm	1.6%
670	Welander Distal Myopathy	1.6%
671	Hyperprolactinemia	1.6%
672	Phantom pain	1.6%
673	Phantom Limb Pain	1.6%
674	Neurocysticercosis	1.6%
675	Amaurosis Fugax	1.6%
676	Blindness, Cortical	1.6%
677	Lyme Neuroborreliosis	1.6%
678	Dyscalculia	1.6%
679	Intracranial Arteriosclerosis	1.6%
680	Cerebral Atherosclerosis	1.6%
681	Rett Syndrome	1.6%
682	Subarachnoid Hemorrhage	1.6%
683	Cerebral Arteriosclerosis	1.6%
684	Cerebral Hemorrhage	1.6%
685	Cerebral Thrombosis	1.6%
686	Intracranial Embolism	1.6%
687	Intracranial Thrombosis	1.6%
688	Deafness	1.6%
689	Hearing Loss, Sudden	1.6%
690	Gerstmann Syndrome	1.6%
691	Hearing Loss, Bilateral	1.6%
692	Hearing Loss, High-Frequency	1.6%
693	Hearing Loss, Mixed Conductive-Sensorineural	1.6%
694	Prosopagnosia	1.6%
695	Apraxia, Ideomotor	1.6%
696	Charles Bonnet Syndrome	1.6%
697	Hearing Loss, Unilateral	1.6%
698	Complete Hearing Loss	1.6%
699	Alien Hand Syndrome	1.6%
700	Deaf Mutism	1.6%
701	Subclavian Steal Syndrome	1.6%
702	Pick Disease of the Brain	1.6%
703	Cataplexy	1.6%
704	Aphasia	1.6%
705	Articulation Disorders	1.6%
706	Echolalia	1.6%
707	Stuttering	1.6%
708	Dysphasia	1.6%
709	Menkes Kinky Hair Syndrome	1.5%
710	Waterhouse-Friderichsen Syndrome	1.5%
711	Hydrops Fetalis	1.5%
712	Dysarthria	1.4%
713	Dermatomyositis	1.4%
714	Corneal Scar	1.4%
715	Muscular Dystrophy, Duchenne	1.4%
716	Retrograde amnesia	1.4%
717	Amnesia, Anterograde	1.4%
718	Lymphoma	1.4%
719	Carotid Artery Thrombosis	1.4%
720	Mastocytosis	1.4%
721	Drug Eruptions	1.4%
722	Chronic granulomatous disease	1.4%
723	Heavy Chain Disease	1.4%
724	Mutism	1.4%
725	Selective Mutism	1.4%
726	Acromegaly	1.3%
727	Dermatitis, Allergic Contact	1.3%
728	HIV Seropositivity	1.3%
729	Cerebral Amyloid Angiopathy	1.3%
730	Sinus Thrombosis, Intracranial	1.3%
731	Rubinstein-Taybi Syndrome	1.3%
732	Sezary Syndrome	1.3%
733	Fragile X Syndrome	1.2%
734	Milk Allergy	1.2%
735	Schnitzler Syndrome	1.2%
736	Wheat Hypersensitivity	1.2%
737	Alexia, Pure	1.2%
738	Cavernous Sinus Thrombosis	1.2%
739	Sagittal Sinus Thrombosis	1.2%
740	Acquired Immunodeficiency Syndrome	1.2%
741	AIDS related complex	1.2%
742	Infectious Mononucleosis	1.2%
743	Cryoglobulinemia	1.2%
744	Corneal Perforation	1.2%
745	Fabry Disease	1.1%
746	Galactosemias	1.1%
747	Urea Cycle Disorders, Inborn	1.1%
748	Tyrosinemias	1.1%
749	AIDS-Related Opportunistic Infections	1%
750	Nelson Syndrome	1%
751	Dermatitis, Atopic	1%
752	HIV Wasting Syndrome	1%
753	AIDS-Associated Nephropathy	1%
754	Prolactinoma	1%
755	Growth Hormone-Secreting Pituitary Adenoma	1%
756	Homocystinuria	1%
757	Leigh Disease	1%
758	Mastocytosis, Systemic	1%
759	Waldenstrom Macroglobulinemia	0.9%
760	Wiskott-Aldrich Syndrome	0.9%
761	HIV-Associated Lipodystrophy Syndrome	0.9%
762	Mucopolysaccharidosis II	0.9%
763	Angioedema	0.8%
764	Hodgkin Disease	0.8%
765	Leukemia, Plasma Cell	0.8%
766	Lymphoma, Non-Hodgkin	0.8%
767	Leukemia, T-Cell	0.8%
768	Acute Generalized Exanthematous Pustulosis	0.8%
769	Leukemia, B-Cell	0.8%
770	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.8%
771	Zellweger Syndrome	0.8%
772	Glycogen storage disease type II	0.7%
773	Asthma	0.7%
774	Composite Lymphoma	0.7%
775	Erythema Nodosum	0.7%
776	Dermatitis, Photoallergic	0.7%
777	Lymphangioleiomyomatosis	0.7%
778	Aspergillosis, Allergic Bronchopulmonary	0.6%
779	Gaucher Disease	0.6%
780	Tay-Sachs Disease	0.5%
781	Asthma, Exercise-Induced	0.5%
782	Status Asthmaticus	0.5%
783	Toxic Epidermal Necrolysis	0.5%
784	Stevens-Johnson Syndrome	0.5%
785	Lymphoma, Follicular	0.5%
786	T-Cell Lymphoma	0.5%
787	Mantle cell lymphoma	0.5%
788	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
789	Leukemia, Large Granular Lymphocytic	0.5%
790	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
791	Niemann-Pick Disease, Type C	0.5%
792	Asthma, Occupational	0.5%
793	Farmer's Lung	0.5%
794	Angioedemas, Hereditary	0.5%
795	Hay fever	0.5%
796	Rhinitis, Allergic, Perennial	0.5%
797	Hereditary Angioedema Type III	0.4%
798	Hereditary Angioedema Types I and II	0.4%
799	Lymphoma, T-Cell, Cutaneous	0.4%
800	Lymphoma, AIDS-Related	0.4%
801	Enteropathy-Associated T-Cell Lymphoma	0.4%
802	Primary Effusion Lymphoma	0.4%
803	Lymphomatoid Granulomatosis	0.3%
804	Mycosis Fungoides	0.3%
805	Lymphomatoid Papulosis	0.3%
806	Plasmablastic lymphoma	0.3%
807	Burkitt Lymphoma	0.3%

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